gossypol and apogossypol

gossypol has been researched along with apogossypol in 21 studies

Research

Studies (21)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	9 (42.86)	29.6817
2010's	11 (52.38)	24.3611
2020's	1 (4.76)	2.80

Authors

Authors	Studies
Cao, X; Cui, Y; Jiang, B; Jiang, H; Wang, F; Zhang, L; Zhao, H	1
Cellitti, J; Dahl, R; Emdadi, A; Kitada, S; Pellecchia, M; Reed, JC; Rega, MF; Stebbins, JL; Wei, J; Yang, L; Yuan, H; Zhai, D; Zhang, Z	1
An, J; Huang, Z; Mao, Y; Xu, Y; Yang, S; Zhang, H	1
Gampe, C; Verma, VA	1
Becattini, B; Chandler, S; Kipps, TJ; Kitada, S; Leone, M; Monosov, E; Pellecchia, M; Reed, JC; Zhai, D	1
Coward, L; Gorman, G; Jia, L; Kerstner-Wood, C; Noker, P; Pellecchia, M; Reed, JC	1
Cork, RL; Coward, LC; Gorman, GS; Jia, L; Kerstner-Wood, CD; Kitada, S; Noker, PE; Pellecchia, M; Reed, JC	1
Jia, L; Kitada, S; Krajewska, M; Kress, CL; Pellecchia, M; Reed, JC	1
Aboukameel, A; Al-Katib, A; Arnold, AA; Banerjee, S; Chen, J; Lin, Y; Ling, X; Mohammad, RM; Nikolovska-Coleska, Z; Sun, Y; Wang, S; Wu, J; Yang, D	1
Kitada, S; Pellecchia, M; Reed, JC; Rega, MF; Risbood, P; Seltzman, HH; Twine, CE; Wei, J; Yuan, H; Zhai, D	1
Cellitti, J; Dahl, R; Emdadi, A; Kitada, S; Lawrence, N; Pellecchia, M; Reed, JC; Reed, TA; Rega, MF; Sebti, S; Stebbins, JL; Sun, J; Wang, HG; Wang, S; Wei, J; Wu, B; Yang, L; Yuan, H; Zhai, D; Zhang, Z	1
Cellitti, J; Dahl, R; Dash, R; Fisher, PB; Kitada, S; Pellecchia, M; Placzek, W; Reed, JC; Rega, MF; Stebbins, JL; Wei, J; Wu, B; Yang, L; Zhai, D	1
Brien, J; Castanet, AS; Chau, NT; Le, TT; Mortier, J; Nguyen, KP; Nguyen, TT; Nourry, A; Thai, TT	1
Azab, B; Curiel, DT; Das, SK; Dash, R; Dent, P; Dmitriev, IP; Fisher, PB; Grant, S; Hedvat, M; Pellecchia, M; Quinn, BA; Rahmani, M; Reed, JC; Sarkar, D; Shen, X; Stebbins, JL; Wang, XY; Wei, J; Wu, B	1
Azab, B; Bhutia, SK; Curiel, DT; Das, SK; Dash, R; Dent, P; Dmitriev, IP; Fisher, PB; Grant, S; Hedvat, M; Pellecchia, M; Quinn, BA; Reed, JC; Sarkar, D; Sarkar, S; Shen, XN; Wang, XY	1
Bampton, ET; Butterworth, M; Caves, RE; Cohen, GM; Dinsdale, D; Gant, TW; Mitcheson, J; Pellecchia, M; Smalley, JL; Tanaka, K; Varadarajan, S; Wei, J	1
Bampton, ET; Cohen, GM; Dinsdale, D; Pellecchia, M; Smalley, JL; Tanaka, K; Varadarajan, S; Willars, GB	1
Hu, H; Liang, J; Liu, M; Nie, Y; Tian, J; Wu, K; Xia, L; Xin, J; Zhan, Y	1
An, Q; Hu, X; Huang, X; Yi, J; Zhan, W	1
Das, SK; Dash, R; Emdad, L; Fisher, PB; Klibanov, AL; Pellecchia, M; Quinn, BA; Sarkar, D; Sarkar, S; Shen, XN; Wang, XY	1
Cohen, GM; Milani, M; Varadarajan, S; Yedida, G	1

Reviews

2 review(s) available for gossypol and apogossypol

Article	Year
The chemical biology of apoptosis: Revisited after 17 years. European journal of medicinal chemistry, 2019, Sep-01, Volume: 177 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Drug Design; Humans; Neoplasms; Proto-Oncogene Proteins c-bcl-2	2019
Curse or Cure? A Perspective on the Developability of Aldehydes as Active Pharmaceutical Ingredients. Journal of medicinal chemistry, 2020, 12-10, Volume: 63, Issue:23 Topics: Aldehydes; Excipients; Pharmaceutical Preparations	2020

Other Studies

19 other study(ies) available for gossypol and apogossypol

Article	Year
Chiral gossypol derivatives: evaluation of their anticancer activity and molecular modeling. European journal of medicinal chemistry, 2009, Volume: 44, Issue:10 Topics: Cell Line, Tumor; Drug Screening Assays, Antitumor; Gossypol; HeLa Cells; Humans; Models, Molecular; Molecular Conformation; Protein Binding; Proto-Oncogene Proteins c-bcl-2; Schiff Bases; Structure-Activity Relationship	2009
Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. Journal of medicinal chemistry, 2009, Jul-23, Volume: 52, Issue:14 Topics: Alkylation; Amides; Animals; Apoptosis; Cell Line; Cell Survival; Gossypol; Humans; Ketones; Magnetic Resonance Spectroscopy; Mice; Microsomes; Permeability; Proto-Oncogene Proteins c-bcl-2; Substrate Specificity	2009
Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-X(L). Chemistry & biology, 2004, Volume: 11, Issue:3 Topics: Acetates; Apoptosis; bcl-X Protein; Cell Line, Tumor; Cell Survival; Drug Design; Gossypol; Humans; Magnetic Resonance Spectroscopy; Microscopy, Confocal; Models, Molecular; Molecular Structure; Proto-Oncogene Proteins c-bcl-2; Spectrometry, Fluorescence; Structure-Activity Relationship; Time Factors	2004
Quantitative determination of apogossypol, a pro-apoptotic analog of gossypol, in mouse plasma using LC/MS/MS. Journal of pharmaceutical and biomedical analysis, 2006, Nov-16, Volume: 42, Issue:5 Topics: Animals; Apoptosis; Chromatography, Liquid; Gossypol; Injections, Intravenous; Male; Mice; Mice, Inbred Strains; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry	2006
Comparison of pharmacokinetic and metabolic profiling among gossypol, apogossypol and apogossypol hexaacetate. Cancer chemotherapy and pharmacology, 2008, Volume: 61, Issue:1 Topics: Acetates; Administration, Oral; Animals; Area Under Curve; Biological Availability; Chromatography, Liquid; Contraceptive Agents, Male; Dogs; Drug Carriers; Drug Stability; Gossypium; Gossypol; Humans; Injections, Intravenous; Male; Mice; Microsomes, Liver; Rats; Species Specificity; Tandem Mass Spectrometry; Tissue Distribution	2008
Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048). Blood, 2008, Mar-15, Volume: 111, Issue:6 Topics: Animals; B-Lymphocytes; Cell Survival; Cells, Cultured; Female; Gossypol; Humans; Leukemia; Lymphoma, B-Cell; Mice; Mice, Inbred BALB C; Mice, Transgenic; Proto-Oncogene Proteins c-bcl-2	2008
Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo. Cancer biology & therapy, 2008, Volume: 7, Issue:9 Topics: Animals; Apoptosis; bcl-X Protein; Caspase 3; Caspase 9; Cell Death; Cell Line, Tumor; Cell Proliferation; Clinical Trials, Phase II as Topic; Dose-Response Relationship, Drug; Drug Stability; Gossypol; Humans; Inhibitory Concentration 50; Lymphoma, Large B-Cell, Diffuse; Mice; Mice, SCID; Molecular Structure; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Recombinant Proteins; Temperature; Time Factors; Xenograft Model Antitumor Assays	2008
Synthesis and evaluation of Apogossypol atropisomers as potential Bcl-xL antagonists. Cancer letters, 2009, Jan-08, Volume: 273, Issue:1 Topics: Antineoplastic Agents; bcl-X Protein; Cell Line, Tumor; Cell Survival; Fluorescence Polarization; Gossypol; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Stereoisomerism	2009
Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins. Molecular cancer therapeutics, 2009, Volume: 8, Issue:4 Topics: Animals; Apoptosis Regulatory Proteins; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; Bcl-2-Like Protein 11; bcl-X Protein; Cell Survival; Female; Fluorescence Polarization; Gossypol; Humans; Lung Neoplasms; Lymphoma; Magnetic Resonance Spectroscopy; Male; Membrane Proteins; Membranes, Artificial; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, Transgenic; Microsomes, Liver; Models, Molecular; Myeloid Cell Leukemia Sequence 1 Protein; Peptide Fragments; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Tumor Cells, Cultured	2009
BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. Journal of medicinal chemistry, 2010, May-27, Volume: 53, Issue:10 Topics: Animals; Antineoplastic Agents; Apoptosis; Binding, Competitive; Cell Proliferation; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; Fluorescence Polarization; Gossypol; Humans; Magnetic Resonance Spectroscopy; Mice; Mice, Transgenic; Models, Molecular; Neoplasm Transplantation; Protein Binding; Proto-Oncogene Proteins c-bcl-2; Stereoisomerism; Transplantation, Heterologous	2010
Evidence for a trianion intermediate in the metalation of 4-hydroxy-6,7-dimethoxy-8-methyl-2-naphthoic acid. Methodology and application to racemic 5,5'-didesisopropyl-5,5'-dialkylapogossypol derivatives. The Journal of organic chemistry, 2011, Jan-21, Volume: 76, Issue:2 Topics: Animals; Anions; Apoptosis; Gossypol; Lithium Compounds; Magnetic Resonance Spectroscopy; Metals; Mice; Molecular Structure; Naphthalenes; Proto-Oncogene Proteins c-bcl-2; Stereoisomerism	2011
Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity. Proceedings of the National Academy of Sciences of the United States of America, 2011, May-24, Volume: 108, Issue:21 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Genetic Therapy; Gossypol; Humans; Interleukins; Male; Mice; Mice, Nude; Myeloid Cell Leukemia Sequence 1 Protein; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Transfection; Xenograft Model Antitumor Assays	2011
Enhanced delivery of mda-7/IL-24 using a serotype chimeric adenovirus (Ad.5/3) in combination with the Apogossypol derivative BI-97C1 (Sabutoclax) improves therapeutic efficacy in low CAR colorectal cancer cells. Journal of cellular physiology, 2012, Volume: 227, Issue:5 Topics: Adenoviridae; Animals; Cell Line, Tumor; Colorectal Neoplasms; Coxsackie and Adenovirus Receptor-Like Membrane Protein; Drug Synergism; Gene Transfer Techniques; Gossypol; Humans; Interleukins; Mice; Mice, Nude; Neoplasms, Experimental; Receptors, Virus; Transgenes; Treatment Outcome; Xenograft Model Antitumor Assays	2012
A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum. Cell death and differentiation, 2012, Volume: 19, Issue:12 Topics: Animals; Cell Line; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Ether-A-Go-Go Potassium Channels; Gossypol; HeLa Cells; Humans; MCF-7 Cells; Mice; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2; RNA Interference; RNA, Small Interfering; Unfolded Protein Response	2012
Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis. PloS one, 2013, Volume: 8, Issue:2 Topics: Calcium; Calmodulin; Cluster Analysis; Endoplasmic Reticulum; Gossypol; HeLa Cells; Homeostasis; Humans; Intracellular Membranes; Membrane Proteins; Neoplasm Proteins; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sodium; Stromal Interaction Molecule 1	2013
ApoG2 induces ER stress-dependent apoptosis in gastric cancer cells in vitro and its real-time evaluation by bioluminescence imaging in vivo. Cancer letters, 2013, Aug-19, Volume: 336, Issue:2 Topics: Animals; Apoptosis; Calcium; Cell Line, Tumor; Cell Survival; Endoplasmic Reticulum Stress; Female; Gossypol; Humans; Luminescent Measurements; Mice; Mice, Nude; Random Allocation; Reactive Oxygen Species; Stomach Neoplasms; Xenograft Model Antitumor Assays	2013
Inhibitory activity of apogossypol in human prostate cancer in vitro and in vivo. Molecular medicine reports, 2015, Volume: 11, Issue:6 Topics: Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 8; Cell Line, Tumor; Cell Proliferation; Female; Gossypol; Humans; Male; Mice, Nude; Prostate; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2	2015
Therapy of prostate cancer using a novel cancer terminator virus and a small molecule BH-3 mimetic. Oncotarget, 2015, May-10, Volume: 6, Issue:13 Topics: Adenoviridae; Animals; Antineoplastic Agents; Apoptosis; Biological Mimicry; Cell Line, Tumor; Cysteine-Rich Protein 61; Dose-Response Relationship, Drug; Endoplasmic Reticulum Stress; Gossypol; Humans; Interleukins; Male; Mice, Nude; Mice, Transgenic; Myeloid Cell Leukemia Sequence 1 Protein; Oncolytic Virotherapy; Oncolytic Viruses; Peptide Fragments; Promoter Regions, Genetic; Prostatic Neoplasms; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Rats; Time Factors; Transfection; Tumor Burden; Xenograft Model Antitumor Assays	2015
Apogossypol-mediated reorganisation of the endoplasmic reticulum antagonises mitochondrial fission and apoptosis. Cell death & disease, 2019, 07-08, Volume: 10, Issue:7 Topics: Apoptosis; bcl-2-Associated X Protein; Crotonates; Cytochromes c; Endoplasmic Reticulum; Gossypol; HeLa Cells; Humans; Hydroxybutyrates; Intracellular Membranes; Leflunomide; Mitochondria; Mitochondrial Dynamics; Models, Biological; Nitriles; Protein Transport; Toluidines	2019