gossypol has been researched along with abt-199 in 8 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| He, S; Li, J; Lu, Y; Tang, J; Wang, W; Wu, S; Yue, Y; Zhou, HB | 1 |
| An, J; Huang, Z; Mao, Y; Xu, Y; Yang, S; Zhang, H | 1 |
| Brewitz, L; Schofield, CJ; Tumber, A; Zhang, X | 1 |
| Deng, H; Huang, M; Liu, D; Luan, S; Niu, Q; Xu, Q; Zhang, Z; Zhao, L | 1 |
| Billard, C | 1 |
| Danilov, AV; Eastman, A; Soderquist, RS | 1 |
| Anderson, MA; Huang, D; Roberts, A | 1 |
| Davids, MS; Lampson, BL | 1 |
4 review(s) available for gossypol and abt-199
| Article | Year |
|---|---|
The chemical biology of apoptosis: Revisited after 17 years.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Drug Design; Humans; Neoplasms; Proto-Oncogene Proteins c-bcl-2 | 2019 |
BH3 mimetics: status of the field and new developments.
Topics: Amino Acid Motifs; Aniline Compounds; Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Clinical Trials as Topic; Drug Design; Drug Screening Assays, Antitumor; Gossypol; Humans; Indoles; Molecular Mimicry; Neoplasms; Peptide Fragments; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides | 2013 |
Targeting BCL2 for the treatment of lymphoid malignancies.
Topics: Aniline Compounds; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Gossypol; Hematologic Neoplasms; Humans; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Peptide Fragments; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides | 2014 |
The Development and Current Use of BCL-2 Inhibitors for the Treatment of Chronic Lymphocytic Leukemia.
Topics: Aniline Compounds; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Gossypol; Humans; Indoles; Leukemia, Lymphocytic, Chronic, B-Cell; Neutropenia; Proto-Oncogene Proteins c-bcl-2; Pyrroles; Sulfonamides; Thionucleotides | 2017 |
4 other study(ies) available for gossypol and abt-199
| Article | Year |
|---|---|
Gossypol with Hydrophobic Linear Esters Exhibits Enhanced Antitumor Activity as an Inhibitor of Antiapoptotic Proteins.
Topics: | 2016 |
Small-molecule active pharmaceutical ingredients of approved cancer therapeutics inhibit human aspartate/asparagine-β-hydroxylase.
Topics: Antibiotics, Antineoplastic; Bleomycin; Dose-Response Relationship, Drug; Drug Compounding; Enzyme Inhibitors; Gossypol; Humans; Mixed Function Oxygenases; Molecular Docking Simulation; Molecular Structure; Small Molecule Libraries; Structure-Activity Relationship | 2020 |
Design, synthesis and biological evaluation of dual Bcl-2/Mcl-1 inhibitors bearing 2-(1H-indol-4-yl)benzoic acid scaffold.
Topics: Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Design; Molecular Structure; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2; Structure-Activity Relationship | 2021 |
Gossypol increases expression of the pro-apoptotic BH3-only protein NOXA through a novel mechanism involving phospholipase A2, cytoplasmic calcium, and endoplasmic reticulum stress.
Topics: Base Sequence; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Line, Tumor; Cytoplasm; Endoplasmic Reticulum Stress; Gene Expression Regulation; Gossypol; Humans; Phospholipases A2; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Sulfonamides | 2014 |