gossypol-acetic-acid and alpha-ketocaproic-acid

gossypol-acetic-acid has been researched along with alpha-ketocaproic-acid* in 1 studies

Other Studies

1 other study(ies) available for gossypol-acetic-acid and alpha-ketocaproic-acid

Article	Year
Inhibition studies on LDH isoenzyme purified from Uromastix testes. Journal of enzyme inhibition, 1996, Volume: 10, Issue:3 An LDH isoenzyme was purified to homogeneity from uromastix testes and its inhibition spectrum towards known LDH isoenzyme inhibitors studied. Platinum compounds inhibited the enzyme in the forward reaction (pyruvate-->lactate) only, n-hexanediol and colchicine showed no inhibition and gossypol acetic acid (GAA) strongly inhibited both the forward and reverse reactions and the reactions were time-dependent. Oxalate caused non-competitive inhibition (Ki app = IC50 = 0.15 mM) of the forward reaction, NADH was more effective in blocking inhibition by GAA than pyruvate. This enzyme was also unable to use ketocaproic acid as a substrate. Topics: Animals; Antineoplastic Agents; Caproates; Cisplatin; Enzyme Inhibitors; Gossypol; Isoenzymes; L-Lactate Dehydrogenase; Lizards; Male; NAD; Oxalates; Oxalic Acid; Pyruvic Acid; Testis	1996

Article

Year

Inhibition studies on LDH isoenzyme purified from Uromastix testes.

Journal of enzyme inhibition, 1996, Volume: 10, Issue:3

An LDH isoenzyme was purified to homogeneity from uromastix testes and its inhibition spectrum towards known LDH isoenzyme inhibitors studied. Platinum compounds inhibited the enzyme in the forward reaction (pyruvate-->lactate) only, n-hexanediol and colchicine showed no inhibition and gossypol acetic acid (GAA) strongly inhibited both the forward and reverse reactions and the reactions were time-dependent. Oxalate caused non-competitive inhibition (Ki app = IC50 = 0.15 mM) of the forward reaction, NADH was more effective in blocking inhibition by GAA than pyruvate. This enzyme was also unable to use ketocaproic acid as a substrate.

Topics: Animals; Antineoplastic Agents; Caproates; Cisplatin; Enzyme Inhibitors; Gossypol; Isoenzymes; L-Lactate Dehydrogenase; Lizards; Male; NAD; Oxalates; Oxalic Acid; Pyruvic Acid; Testis

1996