gossypin and nitroxyl

The mast cell-mediated allergic reactions are involved in many allergic diseases, such as asthma, allergic rhinitis and sinusitis. Stimulation of mast cells initiates the process of degranulation, resulting in the release of mediators such as histamine and an array of inflammatory cytokines. In this report, we investigated the effect of gossypin (a biflavonoid) and suramin (a synthetic polysulphonated naphtylurea) on the mast cell-mediated allergy model, and studied the possible mechanism of their action. Both gossypin and suramin inhibited (P<0.001) compound 48/80-induced systemic anaphylaxis reactions, antiprurities (P<0.001) and reduced the histamine release in rats. Further, both showed significant (P<0.001) protection against rat peritoneal mast cells activated by compound 48/80. Thus, our findings provide evidence that gossypin and suramin inhibit mast cell-derived allergic reactions.

Topics: Anaphylaxis; Animals; Anti-Allergic Agents; Antipruritics; Ascitic Fluid; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Female; Flavonoids; Histamine Release; Hypersensitivity; Male; Mast Cells; Mice; Nitrogen Oxides; p-Methoxy-N-methylphenethylamine; Rats; Suramin