gossylic nitrile-1,1'-diacetate has been researched along with gossypol in 5 studies
| Studies (gossylic nitrile-1,1'-diacetate) | Trials (gossylic nitrile-1,1'-diacetate) | Recent Studies (post-2010) (gossylic nitrile-1,1'-diacetate) | Studies (gossypol) | Trials (gossypol) | Recent Studies (post-2010) (gossypol) |
|---|---|---|---|---|---|
| 5 | 0 | 1 | 1,810 | 47 | 471 |
| Protein | Taxonomy | gossylic nitrile-1,1'-diacetate (IC50) | gossypol (IC50) |
|---|---|---|---|
| Mcl-1 | Homo sapiens (human) | 1.1916 | |
| Estrogen receptor 1 | Homo sapiens (human) | 2.5513 | |
| Prolyl endopeptidase | Rattus norvegicus (Norway rat) | 0.28 | |
| Malate dehydrogenase, mitochondrial | Sus scrofa (pig) | 4.2683 | |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | 0.86 | |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | 0.86 | |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | 0.86 | |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | 0.86 | |
| Apoptosis regulator Bcl-2 | Homo sapiens (human) | 0.8268 | |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | 0.86 | |
| Malate dehydrogenase, cytoplasmic | Sus scrofa (pig) | 4.7683 | |
| DNA-3-methyladenine glycosylase | Homo sapiens (human) | 3 | |
| Caspase-1 | Homo sapiens (human) | 1.23 | |
| DNA repair protein RAD52 homolog | Homo sapiens (human) | 5 | |
| 5-hydroxytryptamine receptor 7 | Cavia porcellus (domestic guinea pig) | 2.274 | |
| BH3-interacting domain death agonist | Homo sapiens (human) | 2.39 | |
| Bcl-2-like protein 1 | Homo sapiens (human) | 2.784 | |
| Induced myeloid leukemia cell differentiation protein Mcl-1 | Homo sapiens (human) | 1.8192 | |
| L-lactate dehydrogenase | Plasmodium falciparum (malaria parasite P. falciparum) | 2.64 | |
| Aspartyl/asparaginyl beta-hydroxylase | Homo sapiens (human) | 0.2725 | |
| L-lactate dehydrogenase | Plasmodium falciparum CDC/Honduras | 4.562 | |
| L-lactate dehydrogenase B chain | Bos taurus (cattle) | 4.562 | |
| L-lactate dehydrogenase | Plasmodium falciparum (malaria parasite P. falciparum) | 2.03 | |
| Inosine-5'-monophosphate dehydrogenase | Pseudomonas aeruginosa PAO1 | 0.9 | |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | 4.5709 | |
| Solute carrier organic anion transporter family member 1B1 | Homo sapiens (human) | 3.2359 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Deck, LM; Royer, RE; Vander Jagt, DL | 1 |
| Campos, NM; Deck, LM; Hunsaker, LA; Royer, RE; Vander Jagt, DL | 1 |
| Kumar, V; Rani, R | 1 |
| Deck, LM; Mertz, GJ; Mills, RG; Royer, RE; Vander Jagt, DL | 1 |
| Clarke, AR; Dewar, V; Holbrook, JJ; Sessions, RB | 1 |
1 review(s) available for gossylic nitrile-1,1'-diacetate and gossypol
| Article | Year |
|---|---|
Recent Update on Human Lactate Dehydrogenase Enzyme 5 (hLDH5) Inhibitors: A Promising Approach for Cancer Chemotherapy.
Topics: Antineoplastic Agents; Drug Design; Enzyme Inhibitors; Humans; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Neoplasms; Structure-Activity Relationship | 2016 |
4 other study(ies) available for gossylic nitrile-1,1'-diacetate and gossypol
| Article | Year |
|---|---|
Gossypol and derivatives: a new class of aldose reductase inhibitors.
Topics: Aldehyde Reductase; Enzyme Inhibitors; Female; Gossypol; Humans; Structure-Activity Relationship | 1991 |
Biologically active derivatives of gossypol: synthesis and antimalarial activities of peri-acylated gossylic nitriles.
Topics: Acylation; Chemical Phenomena; Chemistry; Chloroquine; Drug Resistance; Gossypol; Humans; L-Lactate Dehydrogenase; Nitriles; Plasmodium falciparum | 1986 |
Inhibition of human immunodeficiency virus type I replication by derivatives of gossypol.
Topics: Antiviral Agents; Cell Line; Cell Survival; Gossypol; HIV-1; Humans; Virus Replication | 1991 |
A model of Plasmodium falciparum lactate dehydrogenase and its implications for the design of improved antimalarials and the enhanced detection of parasitaemia.
Topics: Amino Acid Sequence; Animals; Antimalarials; Binding Sites; Crystallography, X-Ray; Drug Design; Geobacillus stearothermophilus; Gossypol; Humans; Kinetics; L-Lactate Dehydrogenase; Lactic Acid; Models, Chemical; Models, Molecular; Molecular Sequence Data; NAD; Plasmodium falciparum; Protein Structure, Tertiary; Sequence Alignment; Sequence Deletion; Stereoisomerism; Swine | 1997 |