Page last updated: 2024-09-03

gossylic nitrile-1,1'-diacetate and gossypol

gossylic nitrile-1,1'-diacetate has been researched along with gossypol in 5 studies

Compound Research Comparison

Studies
(gossylic nitrile-1,1'-diacetate)
Trials
(gossylic nitrile-1,1'-diacetate)
Recent Studies (post-2010)
(gossylic nitrile-1,1'-diacetate)
Studies
(gossypol)
Trials
(gossypol)
Recent Studies (post-2010) (gossypol)
5011,81047471

Protein Interaction Comparison

ProteinTaxonomygossylic nitrile-1,1'-diacetate (IC50)gossypol (IC50)
Mcl-1Homo sapiens (human)1.1916
Estrogen receptor 1Homo sapiens (human)2.5513
Prolyl endopeptidaseRattus norvegicus (Norway rat)0.28
Malate dehydrogenase, mitochondrialSus scrofa (pig)4.2683
Muscarinic acetylcholine receptor M1Rattus norvegicus (Norway rat)0.86
Muscarinic acetylcholine receptor M3Rattus norvegicus (Norway rat)0.86
Muscarinic acetylcholine receptor M4Rattus norvegicus (Norway rat)0.86
Muscarinic acetylcholine receptor M5Rattus norvegicus (Norway rat)0.86
Apoptosis regulator Bcl-2Homo sapiens (human)0.8268
Muscarinic acetylcholine receptor M2Rattus norvegicus (Norway rat)0.86
Malate dehydrogenase, cytoplasmicSus scrofa (pig)4.7683
DNA-3-methyladenine glycosylaseHomo sapiens (human)3
Caspase-1Homo sapiens (human)1.23
DNA repair protein RAD52 homologHomo sapiens (human)5
5-hydroxytryptamine receptor 7Cavia porcellus (domestic guinea pig)2.274
BH3-interacting domain death agonistHomo sapiens (human)2.39
Bcl-2-like protein 1Homo sapiens (human)2.784
Induced myeloid leukemia cell differentiation protein Mcl-1Homo sapiens (human)1.8192
L-lactate dehydrogenasePlasmodium falciparum (malaria parasite P. falciparum)2.64
Aspartyl/asparaginyl beta-hydroxylaseHomo sapiens (human)0.2725
L-lactate dehydrogenasePlasmodium falciparum CDC/Honduras4.562
L-lactate dehydrogenase B chainBos taurus (cattle)4.562
L-lactate dehydrogenasePlasmodium falciparum (malaria parasite P. falciparum)2.03
Inosine-5'-monophosphate dehydrogenase Pseudomonas aeruginosa PAO10.9
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)4.5709
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)3.2359

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19901 (20.00)18.7374
1990's3 (60.00)18.2507
2000's0 (0.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Deck, LM; Royer, RE; Vander Jagt, DL1
Campos, NM; Deck, LM; Hunsaker, LA; Royer, RE; Vander Jagt, DL1
Kumar, V; Rani, R1
Deck, LM; Mertz, GJ; Mills, RG; Royer, RE; Vander Jagt, DL1
Clarke, AR; Dewar, V; Holbrook, JJ; Sessions, RB1

Reviews

1 review(s) available for gossylic nitrile-1,1'-diacetate and gossypol

ArticleYear
Recent Update on Human Lactate Dehydrogenase Enzyme 5 (hLDH5) Inhibitors: A Promising Approach for Cancer Chemotherapy.
    Journal of medicinal chemistry, 2016, Jan-28, Volume: 59, Issue:2

    Topics: Antineoplastic Agents; Drug Design; Enzyme Inhibitors; Humans; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Neoplasms; Structure-Activity Relationship

2016

Other Studies

4 other study(ies) available for gossylic nitrile-1,1'-diacetate and gossypol

ArticleYear
Gossypol and derivatives: a new class of aldose reductase inhibitors.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:11

    Topics: Aldehyde Reductase; Enzyme Inhibitors; Female; Gossypol; Humans; Structure-Activity Relationship

1991
Biologically active derivatives of gossypol: synthesis and antimalarial activities of peri-acylated gossylic nitriles.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:9

    Topics: Acylation; Chemical Phenomena; Chemistry; Chloroquine; Drug Resistance; Gossypol; Humans; L-Lactate Dehydrogenase; Nitriles; Plasmodium falciparum

1986
Inhibition of human immunodeficiency virus type I replication by derivatives of gossypol.
    Pharmacological research, 1991, Volume: 24, Issue:4

    Topics: Antiviral Agents; Cell Line; Cell Survival; Gossypol; HIV-1; Humans; Virus Replication

1991
A model of Plasmodium falciparum lactate dehydrogenase and its implications for the design of improved antimalarials and the enhanced detection of parasitaemia.
    Protein engineering, 1997, Volume: 10, Issue:4

    Topics: Amino Acid Sequence; Animals; Antimalarials; Binding Sites; Crystallography, X-Ray; Drug Design; Geobacillus stearothermophilus; Gossypol; Humans; Kinetics; L-Lactate Dehydrogenase; Lactic Acid; Models, Chemical; Models, Molecular; Molecular Sequence Data; NAD; Plasmodium falciparum; Protein Structure, Tertiary; Sequence Alignment; Sequence Deletion; Stereoisomerism; Swine

1997