go 6976 has been researched along with wortmannin in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (13.64) | 18.2507 |
| 2000's | 17 (77.27) | 29.6817 |
| 2010's | 2 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caivano, M; Cohen, P; Davies, SP; Reddy, H | 1 |
| Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H | 1 |
| Giranda, VL; Johnson, EF; Luo, Y; Stewart, KD; Woods, KW | 1 |
| Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N | 1 |
| Alexander, JS; Kevil, CG; Mire, E; Payne, DK | 1 |
| Shibuya, M; Takahashi, T; Ueno, H | 1 |
| Barnes, PJ; Giembycz, MA; Hellewell, PG; Lindsay, MA; Lynch, OT | 1 |
| Adlersberg, M; Gershon, MD; Hsiung, S; Liu, K; Sacktor, T; Tamir, H | 1 |
| Fathallah, H; Giraud, F; Mazière, P; Sauvage, M | 1 |
| Ishizawa, M; Ishizuka, T; Kajita, K; Kanoh, Y; Miura, A; Yasuda, K | 1 |
| Altura, BM; Altura, BT; Wang, J; Yang, ZW; Zheng, T | 2 |
| Chang, LC; Wang, JP | 1 |
| Barnes, PJ; Giembycz, MA; Lindsay, MA; Lynch, OT | 1 |
| Farnell, MB; Genovese, K; He, H; Kogut, MH | 1 |
| Anel, A; Boyer, C; Buferne, M; Martínez-Lorenzo, MJ; Naval, J; Pardo, J; Schmitt-Verhulst, AM | 1 |
| Altura, BM; Altura, BT; Li, J; Li, W; Liu, W | 1 |
| Choi, HJ; Kim, CH; Park, YG | 1 |
| Nakamura, J | 1 |
| Churikov, D; Price, CM | 1 |
| Boaglio, AC; Crocenzi, FA; Mottino, AD; Ochoa, JE; Pellegrino, JM; Roma, MG; Sánchez Pozzi, EJ; Vore, M; Zucchetti, AE | 1 |
| Karam, M; Lassarre, C; Legay, C; Ricort, JM | 1 |
22 other study(ies) available for go 6976 and wortmannin
| Article | Year |
|---|---|
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides | 2000 |
Identifying off-target effects and hidden phenotypes of drugs in human cells.
Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship | 2006 |
Pharmacological and functional comparison of the polo-like kinase family: insight into inhibitor and substrate specificity.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Androstadienes; Binding Sites; Cell Cycle Proteins; Humans; Models, Molecular; Molecular Sequence Data; Peptide Library; Polo-Like Kinase 1; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Substrate Specificity; Wortmannin | 2007 |
The selectivity of protein kinase inhibitors: a further update.
Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera | 2007 |
Vascular permeability factor/vascular endothelial cell growth factor-mediated permeability occurs through disorganization of endothelial junctional proteins.
Topics: Androstadienes; Antigens, CD; Cadherins; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Membrane Permeability; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Flavonoids; Histocytochemistry; Humans; Indoles; Lymphokines; Membrane Proteins; Muscle, Smooth, Vascular; Nitriles; Occludin; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Serum Albumin; Staurosporine; Tyrphostins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin | 1998 |
VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells.
Topics: 3T3 Cells; Adenoviridae; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Chromones; DNA Replication; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genes, ras; Genetic Vectors; Indoles; Lymphokines; Maleimides; MAP Kinase Kinase Kinase 1; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Isoforms; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Rats; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin | 1999 |
'Outside-in' signalling mechanisms underlying CD11b/CD18-mediated NADPH oxidase activation in human adherent blood eosinophils.
Topics: Androstadienes; Carbazoles; CD18 Antigens; Cell Adhesion; Cell Count; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Eosinophils; Humans; Imidazoles; Indoles; Isoenzymes; Macrophage-1 Antigen; Maleimides; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyrazoles; Pyridines; Pyrimidines; Signal Transduction; src-Family Kinases; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin | 1999 |
Ca(2+)-evoked serotonin secretion by parafollicular cells: roles in signal transduction of phosphatidylinositol 3'-kinase, and the gamma and zeta isoforms of protein kinase C.
Topics: Androstadienes; Animals; Calcium; Calcium Channels; Carbazoles; Cell Membrane; Cells, Cultured; Cytosol; Enzyme Inhibitors; Indoles; Isoenzymes; Naphthalenes; Phosphatidylinositol 3-Kinases; Protein Kinase C; Serotonin; Sheep; Signal Transduction; Tetradecanoylphorbol Acetate; Thyroid Gland; Wortmannin | 2000 |
Insulin stimulates NHE1 activity by sequential activation of phosphatidylinositol 3-kinase and protein kinase C zeta in human erythrocytes.
Topics: Androstadienes; Biological Transport; Carbazoles; Enzyme Activation; Erythrocytes; Humans; Indoles; Insulin; Isoenzymes; Maleimides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Protein Kinase C; Protein Kinase C-alpha; Signal Transduction; Sodium-Hydrogen Exchangers; Time Factors; Wortmannin | 2000 |
The role of atypical and conventional PKC in dehydroepiandrosterone-induced glucose uptake and dexamethasone-induced insulin resistance.
Topics: Adipocytes; Adjuvants, Immunologic; Androstadienes; Animals; Antimetabolites; Carbazoles; Cells, Cultured; Dehydroepiandrosterone; Deoxyglucose; Dexamethasone; Enzyme Activation; Enzyme Inhibitors; Genes, Dominant; Glucocorticoids; Glucose; Indoles; Insulin Antagonists; Insulin Resistance; Male; Myristic Acids; Phosphatidylinositol 3-Kinases; Precipitin Tests; Protein Kinase C; Rats; Time Factors; Transfection; Wortmannin | 2000 |
Low [Mg(2+)](o) induces contraction and [Ca(2+)](i) rises in cerebral arteries: roles of ca(2+), PKC, and PI3.
Topics: Androstadienes; Animals; Anticoagulants; Basilar Artery; Caffeine; Calcium; Carbazoles; Chromones; Dogs; Enzyme Inhibitors; Extracellular Space; Heparin; In Vitro Techniques; Indoles; Magnesium; Maleimides; Morpholines; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Ryanodine; Signal Transduction; Thapsigargin; Vasoconstriction; Wortmannin | 2000 |
Importance of PKC and PI3Ks in ethanol-induced contraction of cerebral arterial smooth muscle.
Topics: Androstadienes; Animals; Basilar Artery; Calcium; Carbazoles; Central Nervous System Depressants; Chromones; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Indoles; Male; Maleimides; Morpholines; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Signal Transduction; Stroke; Vasoconstriction; Vasospasm, Intracranial; Wortmannin | 2001 |
Signal transduction pathways for activation of extracellular signal-regulated kinase by arachidonic acid in rat neutrophils.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Androstadienes; Animals; Arachidonic Acid; Arachidonic Acids; Butadienes; Calcium; Carbazoles; Chelating Agents; Chromones; Cyclooxygenase Inhibitors; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; GTP-Binding Protein alpha Subunits, Gi-Go; Heterotrimeric GTP-Binding Proteins; Indoles; Lipoxygenase Inhibitors; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neutrophils; Nitriles; Pertussis Toxin; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Type C Phospholipases; Virulence Factors, Bordetella; Wortmannin | 2001 |
Pharmacological comparison of LTB(4)-induced NADPH oxidase activation in adherent and non-adherent guinea-pig eosinophils.
Topics: Androstadienes; Animals; Antibodies; Carbazoles; CD18 Antigens; Cell Adhesion; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Eosinophils; Flavonoids; Guinea Pigs; Imidazoles; Indoles; Integrin beta1; Intracellular Signaling Peptides and Proteins; Leukotriene B4; Macrophage-1 Antigen; Male; Maleimides; Mitogen-Activated Protein Kinases; NADPH Oxidases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein-Tyrosine Kinases; Pyrazoles; Pyridines; Pyrimidines; Rats; src-Family Kinases; Stilbenes; Syk Kinase; Time Factors; Wortmannin | 2001 |
Pharmacological analysis of signal transduction pathways required for oxidative burst in chicken heterophils stimulated by a Toll-like receptor 2 agonist.
Topics: Androstadienes; Animals; Animals, Newborn; Carbazoles; Chickens; Estrenes; Flavonoids; Indoles; Lipopolysaccharides; Male; Membrane Glycoproteins; Neutrophils; Nitriles; Pyrrolidinones; Receptors, Cell Surface; Respiratory Burst; Signal Transduction; Sulfones; Teichoic Acids; Toll-Like Receptor 2; Toll-Like Receptors; Wortmannin | 2003 |
Differential implication of protein kinase C isoforms in cytotoxic T lymphocyte degranulation and TCR-induced Fas ligand expression.
Topics: Acetophenones; Androstadienes; Animals; Antibodies, Monoclonal; Benzopyrans; Carbazoles; Cell Degranulation; Cell Line; Chromones; Cycloheximide; Cytotoxicity, Immunologic; Dactinomycin; Fas Ligand Protein; Humans; Indoles; Ionomycin; Isoenzymes; Jurkat Cells; Luciferases; Lymphocyte Activation; Membrane Glycoproteins; Mice; Morpholines; Perforin; Phorbol Esters; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pore Forming Cytotoxic Proteins; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Protein Kinase C-theta; Receptor-CD3 Complex, Antigen, T-Cell; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes, Cytotoxic; Transfection; Wortmannin | 2003 |
Mechanisms of hydroxyl radical-induced contraction of rat aorta.
Topics: Androstadienes; Animals; Aorta; Calcium; Carbazoles; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Ferrous Compounds; Genistein; Hydrogen Peroxide; Hydroxyl Radical; In Vitro Techniques; Indoles; Male; Maleimides; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphoinositide-3 Kinase Inhibitors; Proadifen; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Staurosporine; Vasoconstriction; Wortmannin | 2004 |
Lactosylceramide alpha2,3-sialyltransferase is induced via a PKC/ERK/CREB-dependent pathway in K562 human leukemia cells.
Topics: 5' Flanking Region; Androstadienes; Carbazoles; Cell Differentiation; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Humans; Indoles; K562 Cells; Megakaryocytes; Mutation; Neuraminidase; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Promoter Regions, Genetic; Protein Kinase C; Sialyltransferases; Signal Transduction; Tetradecanoylphorbol Acetate; Wortmannin | 2007 |
Protein kinase C-dependent antilipolysis by insulin in rat adipocytes.
Topics: Adipocytes; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Androstadienes; Angiotensin II; Animals; Carbazoles; Carcinogens; Dobutamine; Enzyme Activation; Enzyme Inhibitors; Glycerol; Imidazoles; Indoles; Insulin; Isoenzymes; Lipolysis; Male; Maleimides; Protein Kinase C; Rats; Receptor, Insulin; Tetradecanoylphorbol Acetate; Wortmannin | 2007 |
Pot1 and cell cycle progression cooperate in telomere length regulation.
Topics: Androstadienes; Ataxia Telangiectasia Mutated Proteins; Caffeine; Carbazoles; Cell Cycle; Cell Cycle Proteins; Cell Line; DNA-Binding Proteins; Enzyme Inhibitors; Flow Cytometry; G2 Phase; Humans; Indoles; Kinetics; Protein Serine-Threonine Kinases; S Phase; Shelterin Complex; Tamoxifen; Telomere; Telomere-Binding Proteins; Tumor Suppressor Proteins; Wortmannin | 2008 |
Phosphoinositide 3-kinase/protein kinase B signaling pathway is involved in estradiol 17β-D-glucuronide-induced cholestasis: complementarity with classical protein kinase C.
Topics: 1-Phosphatidylinositol 4-Kinase; Androstadienes; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Canaliculi; Biliary Tract; Carbazoles; Cholestasis; Colchicine; Endocytosis; Estradiol; Glutathione; In Vitro Techniques; Male; Microtubules; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Perfusion; Protein Kinase C; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Signal Transduction; Taurocholic Acid; Wortmannin | 2010 |
Phosphatidylinositol 3-kinase and protein kinase D1 specifically cooperate to negatively regulate the insulin-like growth factor signaling pathway.
Topics: Androstadienes; Carbazoles; Cell Line, Tumor; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Fibroblast Growth Factors; Humans; Indoles; Insulin Receptor Substrate Proteins; Maleimides; Phosphatidylinositol 3-Kinase; Protein Kinase C; Signal Transduction; Somatomedins; Wortmannin | 2012 |