go 6976 has been researched along with rottlerin in 62 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 7 (11.29) | 18.2507 |
2000's | 46 (74.19) | 29.6817 |
2010's | 9 (14.52) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Caivano, M; Cohen, P; Davies, SP; Reddy, H | 1 |
Goekjian, P; Jochum, A; Jung, M; Kunick, C; Marshall, B; Meier, R; Saunders, L; Sippl, W; Trapp, J; Verdin, E | 1 |
Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N | 1 |
Goode, N; Keenan, C; Pears, C | 1 |
Bheekha-Escura, R; Chance, SR; Langdon, JM; MacDonald, SM; MacGlashan, DW | 1 |
Foster, DA; Frankel, P; Hornia, A; Joseph, T; Lu, Z; Sukezane, T; Zhong, M | 1 |
Palmer, TM; Stiles, GL | 1 |
Altman, A; Genestier, L; Green, DR; Kasibhatla, S; Mahboubi, A; Villalba, M | 1 |
Farokhzad, OC; Hrnjez, BJ; Matthews, JB; Song, JC | 1 |
Henriksen, RA; Jirousek, MR; Samokhin, GP; Ways, DK | 1 |
Eckert, RL; Efimova, T | 1 |
Bruni, P; Cencetti, F; Donati, C; Meacci, E; Romiti, E | 1 |
Arif, AS; Banister, RE; Bivalacqua, TJ; D'Souza, FM; De Witt, BJ; Ibrahim, IN; Kaye, AD; Nossaman, BD | 1 |
Shibuya, M; Takahashi, T | 1 |
Chen, JS; Song, JG | 1 |
Entschladen, F; Lang, K; Masur, K; Niggemann, B; Zanker, KS | 1 |
Bradford, AP; Jackson, TA; Koterwas, DM; Schweppe, RE | 1 |
Basu, A; Johnson, CL; Woolard, MD | 1 |
Hsueh, WA; Kim, S; Kintscher, U; Kuroki, T; Law, RE; Liu, Z; Ohba, M; Schönthal, AH; Wakino, S; Yin, F | 1 |
Abrams, WR; Kucich, U; Rosenbloom, J; Rosenbloom, JC | 1 |
Greenstein, S; Hendey, B; Zhu, CL | 1 |
Barritault, D; Crépin, M; Ledoux, D; Liu, JF; Liu, JM | 1 |
Barnett, NL; Bull, ND | 1 |
Gimona, M; Hahne, P; Hai, CM; Harrington, EO | 1 |
Battistini, L; Brosnan, CF; Chen, L; Cipriani, B; Knowles, H | 1 |
Akita, Y; Gutierrez-Hartmann, A; Manning, N; Pickett, CA | 1 |
Bernhardt, R; Bureik, M; Zeeh, A | 1 |
Brunelle, JL; Harrington, EO; Kim, ES; Mennella, K; Rounds, S; Shannon, CJ | 1 |
Brown, MA; Hock, MB | 1 |
Deb, DK; Fish, EN; Kambhampati, S; Lekmine, F; Majchrzak, B; Platanias, LC; Rahman, A; Sassano, A; Uddin, S; Verma, A | 1 |
Douglas, L; Houghton, JA; Izeradjene, K; Szucs, KS; Tillman, DM | 1 |
Chain, BM; Cho, JY; Katz, DR | 1 |
Anel, A; Boyer, C; Buferne, M; Martínez-Lorenzo, MJ; Naval, J; Pardo, J; Schmitt-Verhulst, AM | 1 |
Akiyama, N; Hirabayashi, T; Murayama, T; Shimamura, K; Takashiro, Y | 1 |
Blois, JT; Chiles, TC; Mataraza, JM; Mecklenbraüker, I; Tarakhovsky, A | 1 |
Calvo, M; Enrich, C; Lladó, A; Moretó, J; Sorkin, A; Tebar, F | 1 |
Bahraoui, E; Bennasser, Y; Contreras, X | 1 |
Fan, CY; Katsuyama, M; Yabe-Nishimura, C | 1 |
Breithardt, G; Eschert, H; Leng, J; Pulawski, E; Sindermann, JR; Skaletz-Rorowski, A; Stallmeyer, B | 1 |
Chang, Q; Soper, BD; Tepperman, BL | 1 |
Andreeva, AY; Blasig, IE; Piontek, J; Utepbergenov, DI | 1 |
Ikewaki, N; Inoko, H; Kulski, JK | 1 |
Akal, AB; Chmelíková, E; Jílek, F; Petr, J; Rajmon, R; Rozinek, J; Sedmíková, M; Svestková, D | 1 |
Cho, KA; Jang, IS; Kim, KT; Park, SC; Rhim, JH; Yeo, EJ | 1 |
Li, F; Shi, J; Song, J; Wang, D; Zhou, Y | 1 |
Grybko, MJ; Pores-Fernando, AT; Wurth, GA; Zweifach, A | 1 |
Aronson, PS; Hassan, HA; Karniski, LP; Mentone, S; Rajendran, VM | 1 |
Fan, Y; Li, HL; Li, ZW; Teng, ZY; Wu, XW; Zhang, YN; Zhang, YQ | 1 |
Hahn, JH; Hong, HY; Jeon, KB; Jeon, WK; Kim, BC; Kim, YM; Lim, CJ; Numazawa, S; Park, EH; Yosida, T | 1 |
Alvarez, DF; An, SS; Casserly, B; Choudhary, G; Harrington, EO; King, JA; Klinger, JR; Murray, JD; Owusu-Sarfo, AN; Warburton, R | 1 |
Chiba, Y; Misawa, M; Sakai, H; Yamamoto, M | 1 |
Lee, MC; Tsai-Wu, JJ; Tsao, PN; Wei, SC; Wu, CH | 1 |
Fan, Y; Li, J; Sun, DJ; Wu, XW; Zhang, YN; Zhang, YQ | 1 |
de Boer, J; Dechering, K; Licht, R; Liu, J; Mentink, A; Someren, E; van Blitterswijk, C | 1 |
Lai, R; Li, S; Lin, W; Tchantchou, F; Wen, J; Zhang, Y | 1 |
Fang, J; Huang, J; Li, C; Li, Z; Tian, F; Wang, N; Xie, F | 1 |
Gonzalez-Garcia, JR; Lai, FA; Machaty, Z; Swann, K | 1 |
Chen, RX; Li, Y; Liu, F; Liu, GA | 1 |
Barthwal, MK; Bogra, J; Dikshit, M; Kohli, M; Kothari, N; Rana, M; Singh, A; Singh, V; Tiwari, RL; Verma, A | 1 |
Czerwinski, P; Förstermann, U; Li, H; Xia, N; Xu, H | 1 |
Huntosova, V; Lenkavska, L; Miskovsky, P; Misuth, M; Tomkova, S | 1 |
Kim, BJ; Kim, JN | 1 |
62 other study(ies) available for go 6976 and rottlerin
Article | Year |
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Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides | 2000 |
Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition.
Topics: Acetylation; Adenosine; Binding Sites; Cell Line, Tumor; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Models, Molecular; Molecular Mimicry; Protein Kinase Inhibitors; Sirtuins; Structure-Activity Relationship; Tubulin | 2006 |
The selectivity of protein kinase inhibitors: a further update.
Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera | 2007 |
Isoform specificity of activators and inhibitors of protein kinase C gamma and delta.
Topics: Acetophenones; Alkaloids; Benzophenanthridines; Benzopyrans; Bryostatins; Carbazoles; Enzyme Activation; Enzyme Inhibitors; Indoles; Isoenzymes; Lactones; Macrolides; Maleimides; Naphthalenes; Phenanthridines; Protein Kinase C; Protein Kinase C-delta; Recombinant Proteins; Schizosaccharomyces; Sphingosine; Tetradecanoylphorbol Acetate; Transformation, Genetic | 1997 |
Pharmacologic regulation of histamine release by the human recombinant histamine-releasing factor.
Topics: Acetophenones; Antibodies, Anti-Idiotypic; Basophils; Benzopyrans; Biomarkers, Tumor; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Enzyme Inhibitors; Histamine Release; Humans; Immunoglobulin E; Indoles; Lymphokines; Pertussis Toxin; Protein Kinase C; Recombinant Proteins; Staurosporine; Tumor Protein, Translationally-Controlled 1; Virulence Factors, Bordetella | 1999 |
Antagonistic effects of protein kinase C alpha and delta on both transformation and phospholipase D activity mediated by the epidermal growth factor receptor.
Topics: Acetophenones; Animals; Benzopyrans; Carbazoles; Cell Transformation, Neoplastic; Cells, Cultured; Crosses, Genetic; Epidermal Growth Factor; ErbB Receptors; Indoles; Isoenzymes; Models, Genetic; Mutagenesis, Insertional; Phospholipase D; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Rats; Recombinant Proteins; Tetradecanoylphorbol Acetate | 1999 |
Stimulation of A(2A) adenosine receptor phosphorylation by protein kinase C activation: evidence for regulation by multiple protein kinase C isoforms.
Topics: Acetophenones; Animals; Benzopyrans; Carbazoles; CHO Cells; Consensus Sequence; Cricetinae; Cyclic AMP; Dogs; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Glioma; Indoles; Isoenzymes; Maleimides; Mutagenesis, Site-Directed; Phosphorylation; Protein Kinase C; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; Signal Transduction; Tetradecanoylphorbol Acetate; Triazines; Triazoles; Tumor Cells, Cultured | 1999 |
Protein kinase ctheta cooperates with calcineurin to induce Fas ligand expression during activation-induced T cell death.
Topics: Acetophenones; Animals; Apoptosis; Benzopyrans; Binding Sites; Calcineurin; Carbazoles; DNA-Binding Proteins; Drug Interactions; Fas Ligand Protein; Gene Expression Regulation; Humans; Indoles; Ionomycin; Isoenzymes; Jurkat Cells; Membrane Glycoproteins; Mice; Mutation; NFATC Transcription Factors; Nuclear Proteins; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase C-theta; Signal Transduction; T-Lymphocytes; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription Factors | 1999 |
PKC-epsilon regulates basolateral endocytosis in human T84 intestinal epithelia: role of F-actin and MARCKS.
Topics: Acetophenones; Acetylcholine; Actin Cytoskeleton; Actins; Amino Acid Sequence; Benzopyrans; Biological Transport; Carbachol; Carbazoles; Carcinogens; Cell Membrane; Cell Polarity; Cells, Cultured; Cholinergic Agonists; Cross-Linking Reagents; Cytochalasin D; Diglycerides; Endocytosis; Enzyme Inhibitors; Epithelial Cells; Humans; Indoles; Intestines; Intracellular Signaling Peptides and Proteins; Isoenzymes; Maleimides; Membrane Proteins; Molecular Sequence Data; Myristoylated Alanine-Rich C Kinase Substrate; Nucleic Acid Synthesis Inhibitors; Pinocytosis; Protein Kinase C; Protein Kinase C-epsilon; Proteins; Tetradecanoylphorbol Acetate | 1999 |
Effects of protein kinase C inhibitors on thromboxane production by thrombin-stimulated platelets.
Topics: Acetophenones; Benzopyrans; Blood Platelets; Carbazoles; Enzyme Inhibitors; Humans; In Vitro Techniques; Indoles; Isoenzymes; Maleimides; Platelet Activation; Protein Kinase C; Thrombin; Thromboxanes | 1999 |
Regulation of human involucrin promoter activity by novel protein kinase C isoforms.
Topics: Acetophenones; Benzopyrans; Carbazoles; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Genes, Dominant; Humans; Indoles; Isoenzymes; Keratinocytes; Luciferases; Plasmids; Promoter Regions, Genetic; Protein Isoforms; Protein Kinase C; Protein Kinase C-delta; Protein Kinase C-epsilon; Protein Precursors; Proto-Oncogene Proteins c-fos; Tetradecanoylphorbol Acetate; Transfection | 2000 |
Permissive role of protein kinase C alpha but not protein kinase C delta in sphingosine 1-phosphate-induced Rho A activation in C2C12 myoblasts.
Topics: Acetophenones; Animals; Benzopyrans; Carbazoles; Cell Fractionation; Cell Line; Cell Membrane; Endoplasmic Reticulum; Endosomes; Enzyme Inhibitors; Golgi Apparatus; Indoles; Isoenzymes; Lysophospholipids; Maleimides; Mice; Muscle, Skeletal; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Transport; rhoA GTP-Binding Protein; Sphingosine; Tetradecanoylphorbol Acetate | 2000 |
Effects of PKC isozyme inhibitors on constrictor responses in the feline pulmonary vascular bed.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetophenones; Angiotensin II; Animals; Benzopyrans; Calcium Channel Agonists; Carbazoles; Cats; Drug Interactions; Enzyme Inhibitors; Female; Free Radical Scavengers; Immunohistochemistry; Indoles; Isoenzymes; Male; Muscle, Smooth, Vascular; Norepinephrine; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Pulmonary Circulation; Serotonin; Vasoconstriction; Vasoconstrictor Agents | 2001 |
The overexpression of PKCdelta is involved in vascular endothelial growth factor-resistant apoptosis in cultured primary sinusoidal endothelial cells.
Topics: Acetophenones; Animals; Apoptosis; Benzopyrans; Carbazoles; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Indoles; Isoenzymes; Lymphokines; Protein Kinase C; Protein Kinase C-delta; Rats; Recombinant Proteins; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
Bradykinin induces protein kinase C-dependent activation of phospholipase D in A-431 cells.
Topics: Acetophenones; Benzopyrans; Bradykinin; Carbazoles; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Immunoblotting; Indoles; Isoenzymes; Kinetics; Maleimides; Phospholipase D; Phospholipids; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2001 |
High PKC alpha and low E-cadherin expression contribute to high migratory activity of colon carcinoma cells.
Topics: Acetophenones; Benzopyrans; Biological Transport; Cadherins; Carbazoles; Cell Membrane; Cell Movement; Colonic Neoplasms; Enzyme Activation; Enzyme Inhibitors; Humans; Indoles; Isoenzymes; Oligonucleotides, Antisense; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Sphingosine; Tumor Cells, Cultured | 2001 |
Fibroblast growth factor activation of the rat PRL promoter is mediated by PKCdelta.
Topics: Acetophenones; Adenoviridae; Animals; Benzopyrans; Carbazoles; Culture Media, Serum-Free; Enzyme Activation; Enzyme Inhibitors; Fibroblast Growth Factors; Immunoblotting; Indoles; Isoenzymes; MAP Kinase Signaling System; Naphthalenes; Pituitary Neoplasms; Prolactin; Promoter Regions, Genetic; Protein Isoforms; Protein Kinase C; Protein Kinase C-delta; Rats; Tumor Cells, Cultured | 2001 |
Involvement of protein kinase C-delta in DNA damage-induced apoptosis.
Topics: Acetophenones; Apoptosis; Benzopyrans; Carbazoles; Caspases; Cell Survival; Cisplatin; Cytochrome c Group; DNA Damage; Enzyme Activation; HeLa Cells; Humans; Indoles; Isoenzymes; Maleimides; Mitochondria; Protein Kinase C; Protein Kinase C-delta | 2001 |
Peroxisome proliferator-activated receptor gamma ligands inhibit mitogenic induction of p21(Cip1) by modulating the protein kinase Cdelta pathway in vascular smooth muscle cells.
Topics: Acetophenones; Adenoviridae; Animals; Aorta, Thoracic; Apoptosis; Benzopyrans; Blotting, Western; Carbazoles; Cell Division; Cells, Cultured; Chromans; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cycloheximide; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Hydroquinones; Indoles; Insulin; Isoenzymes; Kinetics; Ligands; Mice; Mitogens; Models, Biological; Muscle, Smooth, Vascular; Phosphorylation; Platelet-Derived Growth Factor; Precipitin Tests; Protein Kinase C; Protein Kinase C-delta; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; RNA; Rosiglitazone; Signal Transduction; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; Tyrosine; Up-Regulation; Vanadates | 2001 |
Transforming growth factor-beta stabilizes elastin mRNA by a pathway requiring active Smads, protein kinase C-delta, and p38.
Topics: Acetophenones; Benzopyrans; Carbazoles; Cells, Cultured; Cycloheximide; DNA-Binding Proteins; Elastin; Enzyme Inhibitors; Fibroblasts; Gene Expression Regulation; Genes, Reporter; Humans; Indoles; Isoenzymes; Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Kinase C-delta; Protein Synthesis Inhibitors; Recombinant Fusion Proteins; RNA, Messenger; Signal Transduction; Smad7 Protein; Time Factors; Trans-Activators; Transforming Growth Factor beta | 2002 |
Fas activation opposes PMA-stimulated changes in the localization of PKCdelta: a mechanism for reducing neutrophil adhesion to endothelial cells.
Topics: Acetophenones; Benzopyrans; Carbazoles; Cell Adhesion; Cell Membrane; Cells, Cultured; Endothelium; Enzyme Inhibitors; fas Receptor; Humans; Indoles; Isoenzymes; Kinetics; Neutrophils; Protein Kinase C; Protein Kinase C-delta; Protein Transport; Tetradecanoylphorbol Acetate | 2002 |
FGF-2 and TPA induce matrix metalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway.
Topics: Acetophenones; Benzopyrans; Carbazoles; Collagenases; Enzyme Inhibitors; Fibroblast Growth Factor 2; Genes, Dominant; Humans; Indoles; Maleimides; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Models, Biological; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-raf; ras Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 2002 |
Antagonists of protein kinase C inhibit rat retinal glutamate transport activity in situ.
Topics: Acetophenones; Alkaloids; Amino Acid Transport System X-AG; Animals; Aspartic Acid; Benzophenanthridines; Benzopyrans; Biological Transport; Blotting, Western; Carbazoles; Enzyme Inhibitors; Glutamic Acid; Immunohistochemistry; In Vitro Techniques; Indoles; Isoenzymes; Phenanthridines; Protein Kinase C; Rats; Rats, Inbred Strains; Retina | 2002 |
Conventional protein kinase C mediates phorbol-dibutyrate-induced cytoskeletal remodeling in a7r5 smooth muscle cells.
Topics: Acetophenones; Actinin; Actins; Amides; Animals; Benzopyrans; Carbazoles; Cells, Cultured; Cytoskeleton; Enzyme Inhibitors; Green Fluorescent Proteins; Indoles; Isoenzymes; Luminescent Proteins; Muscle, Smooth, Vascular; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Transport; Pyridines; Rats; Recombinant Fusion Proteins; Transfection; Vinculin | 2002 |
Involvement of classical and novel protein kinase C isoforms in the response of human V gamma 9V delta 2 T cells to phosphate antigens.
Topics: Acetophenones; Antigens, Bacterial; Benzopyrans; Carbazoles; Cell Division; Cells, Cultured; Chemokines; Cytokines; Hemiterpenes; Humans; Indoles; Isoenzymes; Lymphocyte Activation; Organophosphorus Compounds; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Kinase C-theta; Protein Transport; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocyte Subsets; Transcription Factors | 2002 |
Role of specific protein kinase C isozymes in mediating epidermal growth factor, thyrotropin-releasing hormone, and phorbol ester regulation of the rat prolactin promoter in GH4/GH4C1 pituitary cells.
Topics: Acetophenones; Animals; Benzopyrans; Calcium; Carbazoles; Cell Line; Enzyme Inhibitors; Epidermal Growth Factor; Gene Expression Regulation; Indoles; Isoenzymes; Maleimides; Naphthalenes; Phorbol Esters; Pituitary Gland; Prolactin; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase C-delta; Protein Kinase C-epsilon; Rats; Staurosporine; Thyrotropin-Releasing Hormone; Transcription, Genetic | 2002 |
Modulation of steroid hydroxylase activity in stably transfected V79MZh11B1 and V79MZh11B2 cells by PKC and PKD inhibitors.
Topics: Acetophenones; Alkaloids; Benzophenanthridines; Benzopyrans; Carbazoles; Cell Line; Cortodoxone; Desoxycorticosterone; Enzyme Inhibitors; Hydroxylation; Indoles; Phenanthridines; Protein Kinase C; Staurosporine; Steroid Hydroxylases; Transfection | 2002 |
Role of protein kinase C isoforms in rat epididymal microvascular endothelial barrier function.
Topics: Acetophenones; Animals; Benzopyrans; Carbazoles; Cell Fractionation; Cell Line; Cytoskeletal Proteins; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Epididymis; Focal Adhesions; Indoles; Isoenzymes; Male; Permeability; Protein Kinase C; Protein Transport; Rats; rhoA GTP-Binding Protein; Thrombin | 2003 |
Nuclear factor of activated T cells 2 transactivation in mast cells: a novel isoform-specific transactivation domain confers unique FcepsilonRI responsiveness.
Topics: Acetophenones; Amino Acid Sequence; Animals; Base Sequence; Benzopyrans; Binding Sites; Carbazoles; Cell Line; DNA; DNA-Binding Proteins; Enzyme Inhibitors; In Vitro Techniques; Indoles; Ionomycin; Mast Cells; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; NFATC Transcription Factors; Nuclear Proteins; Protein Isoforms; Protein Kinase C; Protein Kinase C-delta; Protein Structure, Tertiary; Receptors, IgE; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transcription Factors; Transcriptional Activation; Two-Hybrid System Techniques | 2003 |
Activation of protein kinase C delta by IFN-gamma.
Topics: Acetophenones; Benzopyrans; Carbazoles; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Humans; Imidazoles; Indoles; Interferon gamma Receptor; Interferon-gamma; Isoenzymes; Mesylates; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphoserine; Protein Kinase C; Protein Kinase C-delta; Pyridines; Pyrroles; Receptors, Interferon; Signal Transduction; STAT1 Transcription Factor; Trans-Activators; Tumor Cells, Cultured | 2003 |
Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C.
Topics: Acetophenones; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Benzopyrans; Carbazoles; Caspases; Colonic Neoplasms; Drug Synergism; Enzyme Inhibitors; Humans; Indoles; Membrane Glycoproteins; Mitochondria; Naphthalenes; Protein Kinase C; Protein Kinase C-delta; Protein Kinase C-epsilon; Proto-Oncogene Proteins c-bcl-2; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2003 |
Staurosporine induces rapid homotypic intercellular adhesion of U937 cells via multiple kinase activation.
Topics: Acetophenones; Adenosine Triphosphate; Benzopyrans; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; CD18 Antigens; Cell Aggregation; Cycloheximide; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Imidazoles; Indoles; Integrin beta1; Isoenzymes; Maleimides; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Phosphotransferases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Staurosporine; Temperature; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; U937 Cells | 2003 |
Differential implication of protein kinase C isoforms in cytotoxic T lymphocyte degranulation and TCR-induced Fas ligand expression.
Topics: Acetophenones; Androstadienes; Animals; Antibodies, Monoclonal; Benzopyrans; Carbazoles; Cell Degranulation; Cell Line; Chromones; Cycloheximide; Cytotoxicity, Immunologic; Dactinomycin; Fas Ligand Protein; Humans; Indoles; Ionomycin; Isoenzymes; Jurkat Cells; Luciferases; Lymphocyte Activation; Membrane Glycoproteins; Mice; Morpholines; Perforin; Phorbol Esters; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pore Forming Cytotoxic Proteins; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Protein Kinase C-theta; Receptor-CD3 Complex, Antigen, T-Cell; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes, Cytotoxic; Transfection; Wortmannin | 2003 |
Expression of adhesion molecules by sphingosine 1-phosphate and histamine in endothelial cells.
Topics: Acetophenones; Benzopyrans; Blotting, Western; Carbazoles; Cell Adhesion Molecules; Cells, Cultured; E-Selectin; Endothelium, Vascular; Estrenes; Histamine; Histamine Agonists; Humans; Imidazoles; Indoles; Intercellular Adhesion Molecule-1; Lysophospholipids; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Pyridines; Pyrrolidinones; RNA, Messenger; Signal Transduction; Sphingosine; Type C Phospholipases; Umbilical Veins; Vascular Cell Adhesion Molecule-1 | 2004 |
B cell receptor-induced cAMP-response element-binding protein activation in B lymphocytes requires novel protein kinase Cdelta.
Topics: Acetamides; Acetophenones; Animals; B-Lymphocytes; Benzopyrans; Binding Sites; Blotting, Western; Bryostatins; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cell Division; Cross-Linking Reagents; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indoles; Lactones; Macrolides; Mice; Mice, Inbred BALB C; Mice, Inbred CBA; Mitogens; Phosphorylation; Promoter Regions, Genetic; Protein Isoforms; Protein Kinase C; Protein Kinase C-delta; Protein Structure, Tertiary; Pyrans; Receptors, Antigen, B-Cell; Ribosomal Protein S6 Kinases, 90-kDa; Serine; Signal Transduction; Spiro Compounds; Tetradecanoylphorbol Acetate; Time Factors | 2004 |
Protein kinaseCdelta-calmodulin crosstalk regulates epidermal growth factor receptor exit from early endosomes.
Topics: Acetophenones; Animals; Benzopyrans; Biological Transport; Blotting, Western; Brefeldin A; Calmodulin; Carbazoles; COS Cells; Down-Regulation; Endocytosis; Endosomes; Enzyme Inhibitors; ErbB Receptors; Fluorescein-5-isothiocyanate; Gene Expression Regulation; Genes, Dominant; Green Fluorescent Proteins; HeLa Cells; Humans; Indoles; MAP Kinase Signaling System; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Models, Biological; Protein Isoforms; Protein Kinase C; Protein Kinase C-delta; Protein Kinase C-epsilon; Protein Transport; RNA, Small Interfering; Subcellular Fractions; Sulfonamides; Temperature; Time Factors; Transfection | 2004 |
IL-10 production induced by HIV-1 Tat stimulation of human monocytes is dependent on the activation of PKC beta(II) and delta isozymes.
Topics: Acetophenones; Benzopyrans; Carbazoles; Cells, Cultured; Enzyme Inhibitors; Gene Expression Regulation; Gene Products, tat; HIV-1; Humans; Indoles; Interleukin-10; Maleimides; Monocytes; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-delta; Pyrones; tat Gene Products, Human Immunodeficiency Virus | 2004 |
PKCdelta mediates up-regulation of NOX1, a catalytic subunit of NADPH oxidase, via transactivation of the EGF receptor: possible involvement of PKCdelta in vascular hypertrophy.
Topics: Acetophenones; Animals; Benzopyrans; Carbazoles; Catalysis; Cell Line; Enzyme Induction; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gene Silencing; Hypertrophy; Indoles; NADPH Oxidases; Platelet-Derived Growth Factor; Protein Kinase C-delta; Protein Transport; Rats; Transcriptional Activation | 2005 |
PKC delta-induced activation of MAPK pathway is required for bFGF-stimulated proliferation of coronary smooth muscle cells.
Topics: Acetophenones; Benzopyrans; Blotting, Northern; Blotting, Western; Carbazoles; Cell Line; Cell Proliferation; Coronary Vessels; DNA; Enzyme Activation; Enzyme Inhibitors; Fibroblast Growth Factor 2; Humans; Indoles; MAP Kinase Signaling System; Muscle, Smooth, Vascular; Oligonucleotides, Antisense | 2005 |
Effect of protein kinase C activation on intracellular Ca2+ signaling and integrity of intestinal epithelial cells.
Topics: Acetophenones; Animals; Benzopyrans; Calcium; Calcium Channel Blockers; Calcium Signaling; Carbazoles; Cell Line; Cell Survival; Chelating Agents; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Indoles; Intestinal Mucosa; Intracellular Space; Maleimides; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Kinase C-epsilon; Tetradecanoylphorbol Acetate; Verapamil | 2005 |
Assembly of tight junction is regulated by the antagonism of conventional and novel protein kinase C isoforms.
Topics: Acetophenones; Animals; Benzopyrans; Calcium; Carbazoles; Cell Line; Dogs; Enzyme Inhibitors; Indoles; Isoenzymes; Kidney Tubules; Maleimides; Membrane Proteins; Occludin; Permeability; Protein Kinase C; Tight Junctions | 2006 |
Regulation of CD93 cell surface expression by protein kinase C isoenzymes.
Topics: Acetophenones; Benzopyrans; Benzoquinones; Carbazoles; Down-Regulation; Endothelial Cells; Flow Cytometry; Humans; Immunoenzyme Techniques; Indoles; Interferon-gamma; Interleukin-8; Isoenzymes; Isoquinolines; Lactams, Macrocyclic; Membrane Glycoproteins; Monocytes; Protein Kinase C; Protein Kinase Inhibitors; Quinones; Receptors, Complement; Rifabutin; Sulfonamides; Tetradecanoylphorbol Acetate; U937 Cells; Up-Regulation | 2006 |
Effect of protein kinase C inhibitors on porcine oocyte activation.
Topics: Acetophenones; Animals; Benzopyrans; Blotting, Western; Calcimycin; Calcium; Carbazoles; Female; In Vitro Techniques; Indoles; Ionophores; Isoenzymes; Maleimides; Oocytes; Protein Kinase C; Protein Kinase Inhibitors; Pyrones; Swine | 2006 |
Lysophosphatidic acid-induced changes in cAMP profiles in young and senescent human fibroblasts as a clue to the ageing process.
Topics: Acetophenones; Aging; Benzopyrans; Carbazoles; Cell Line; Cellular Senescence; Cyclic AMP; Enzyme Inhibitors; Fibroblasts; Humans; Indoles; Lysophospholipids; Receptors, Lysophosphatidic Acid; RNA, Small Interfering | 2006 |
Different roles of protein kinase C-betaI and -delta in the regulation of adipocyte differentiation.
Topics: 3T3-L1 Cells; Acetophenones; Adipocytes; Adipogenesis; Animals; Benzopyrans; Carbazoles; Cell Differentiation; Cell Membrane; Cell Proliferation; Chromans; Cytosol; Epidermal Growth Factor; Gene Expression; Genes, Dominant; Indoles; Mice; Mutant Proteins; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-delta; Protein Transport; Tetradecanoylphorbol Acetate; Thiazolidinediones; Transforming Growth Factor beta; Troglitazone | 2006 |
Protein kinase C activity is required for cytotoxic T cell lytic granule exocytosis, but the theta isoform does not play a preferential role.
Topics: Acetophenones; Benzopyrans; Calcium; Carbazoles; Cell Line, Tumor; Cell Membrane; Cytotoxicity, Immunologic; Exocytosis; Humans; Indoles; Mutation; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase Inhibitors; Structure-Activity Relationship; T-Lymphocytes, Cytotoxic; Tetradecanoylphorbol Acetate | 2007 |
Regulation of anion exchanger Slc26a6 by protein kinase C.
Topics: Acetophenones; Animals; Anion Transport Proteins; Antiporters; Benzopyrans; Biological Transport, Active; Carbazoles; Cell Membrane; Chlorides; Cytoplasm; Enzyme Activation; Female; Formates; In Vitro Techniques; Indoles; Maleimides; Mice; Oocytes; Oxalates; Protein Kinase C-delta; Protein Transport; Sulfate Transporters; Tetradecanoylphorbol Acetate; Xenopus | 2007 |
[Phosphorylation of PKCdelta participates in the toxicity of 6-hydroxydopamine on dopaminergic neuroblastoma cell].
Topics: Acetophenones; Benzopyrans; Blotting, Western; Carbazoles; Cell Line, Tumor; Cell Survival; Dopamine; Enzyme Activators; Humans; Indoles; Maleimides; Neuroblastoma; Oxidopamine; Phosphorylation; Protein Kinase C-delta; Signal Transduction; Tetradecanoylphorbol Acetate | 2006 |
The anti-inflammatory activity of Phellinus linteus (Berk. & M.A. Curt.) is mediated through the PKCdelta/Nrf2/ARE signaling to up-regulation of heme oxygenase-1.
Topics: Acetophenones; Agaricales; Animals; Anti-Inflammatory Agents; Antioxidants; Benzopyrans; Carbazoles; Cell Line; Dose-Response Relationship, Drug; Heme Oxygenase-1; Immunoblotting; Indoles; Lipopolysaccharides; Luciferases; Macrophages; Maleimides; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; NF-E2-Related Factor 2; Nitric Oxide; Nitric Oxide Synthase Type II; Protein Kinase C-delta; Response Elements; Signal Transduction; Transcription, Genetic; Transfection; Up-Regulation | 2007 |
Rottlerin causes pulmonary edema in vivo: a possible role for PKCdelta.
Topics: Acetophenones; Actomyosin; Animals; Benzopyrans; Capillary Permeability; Carbazoles; Cells, Cultured; Cytoskeleton; Dose-Response Relationship, Drug; Endothelial Cells; Evans Blue; Focal Adhesions; Indoles; Lung; Male; Maleimides; Microcirculation; Protein Kinase C-delta; Protein Kinase Inhibitors; Pulmonary Edema; Rats; Rats, Sprague-Dawley; Time Factors | 2007 |
Probable involvement of epsilon-isoform of protein kinase C in rat bronchial smooth muscle contraction induced by acetylcholine.
Topics: Acetophenones; Acetylcholine; Animals; Benzopyrans; Bronchi; Carbazoles; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indoles; Isoenzymes; Male; Maleimides; Muscle Contraction; Muscle, Smooth; Protein Kinase C-epsilon; Rats; Rats, Wistar | 2008 |
Novel PKC signaling is required for LPS-induced soluble Flt-1 expression in macrophages.
Topics: Acetophenones; Animals; Benzopyrans; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cells, Cultured; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Genes, Dominant; Humans; Indoles; Lipopolysaccharides; Macrophages; Maleimides; Mice; Monocytes; Phosphorylation; Protein Kinase C-delta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transcription, Genetic; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1 | 2008 |
Rottlerin protected dopaminergic cell line from cytotoxicity of 6-hydroxydopamine by inhibiting PKCdelta phosphorylation.
Topics: Acetophenones; Adrenergic Agents; Animals; Benzopyrans; Carbazoles; Cell Survival; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Indoles; Maleimides; Oxidopamine; PC12 Cells; Phorbol Esters; Phosphorylation; Protein Kinase C; Rats; Time Factors | 2009 |
The effect of PKC activation and inhibition on osteogenic differentiation of human mesenchymal stem cells.
Topics: Acetophenones; Benzopyrans; Carbazoles; Cell Differentiation; Cell Proliferation; Enzyme Activation; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Mesenchymal Stem Cells; Osteogenesis; Protein Kinase C; Protein Kinase Inhibitors | 2010 |
Protein kinase C mediates peroxynitrite toxicity to oligodendrocytes.
Topics: Acetophenones; Animals; Benzopyrans; Carbazoles; Cells, Cultured; Chlorides; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Indoles; Isoenzymes; Maleimides; Molsidomine; Oligodendroglia; Peroxynitrous Acid; Protein Kinase C; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Tetradecanoylphorbol Acetate; Zinc Compounds | 2011 |
Role of PKC-ERK signaling in tamoxifen-induced apoptosis and tamoxifen resistance in human breast cancer cells.
Topics: Acetophenones; Antineoplastic Agents, Hormonal; Apoptosis; Benzopyrans; Breast Neoplasms; Carbazoles; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Humans; Protein Kinase C-alpha; Protein Kinase C-delta; Receptors, Estrogen; Signal Transduction; Tamoxifen | 2012 |
The dynamics of PKC-induced phosphorylation triggered by Ca2+ oscillations in mouse eggs.
Topics: Acetophenones; Animals; Benzopyrans; Calcium; Calcium Ionophores; Carbazoles; Diglycerides; Enzyme Inhibitors; Female; Fertilization in Vitro; Gene Expression Regulation, Enzymologic; Ionomycin; Male; Mice; Ovum; Phosphorylation; Protein Kinase C; RNA, Complementary; Spermatozoa; Thapsigargin | 2013 |
Neuromedin S increases L-type Ca(2+) channel currents through G(i)α-protein and phospholipase C-dependent novel protein kinase C delta pathway in adult rat ventricular myocytes.
Topics: Acetophenones; Animals; Benzophenanthridines; Benzopyrans; Calcium Channels, L-Type; Carbazoles; Cells, Cultured; Electrophysiological Phenomena; Estrenes; GTP-Binding Protein alpha Subunits, Gi-Go; Heart Ventricles; Male; Muscle Cells; Neuropeptides; Oligopeptides; Peptide Fragments; Protein Kinase C-delta; Pyrrolidinones; Rats; Receptors, Neurotransmitter; Type C Phospholipases | 2012 |
PKCδ-IRAK1 axis regulates oxidized LDL-induced IL-1β production in monocytes.
Topics: Acetophenones; Acetylcysteine; Adult; Benzofurans; Benzopyrans; Carbazoles; Female; Humans; Indoles; Interleukin-1 Receptor-Associated Kinases; Interleukin-1beta; Lipoproteins, LDL; Male; Middle Aged; Monocytes; Onium Compounds; Protein Kinase C-delta; Reactive Oxygen Species; Systemic Inflammatory Response Syndrome; THP-1 Cells; Toll-Like Receptors | 2014 |
Downregulation of BDNF Expression by PKC and by TNF-α in Human Endothelial Cells.
Topics: Acetophenones; Benzopyrans; Brain-Derived Neurotrophic Factor; Carbazoles; Down-Regulation; Endothelial Cells; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Maleimides; Neovascularization, Physiologic; Nerve Tissue Proteins; Peptides, Cyclic; Phorbol Esters; Protein Kinase C; Receptor, trkB; Receptors, Nerve Growth Factor; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2015 |
In vitro identification of mitochondrial oxidative stress production by time-resolved fluorescence imaging of glioma cells.
Topics: Acetophenones; Antimycin A; Apoptosis; Benzopyrans; Carbazoles; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Line, Tumor; Flow Cytometry; Glioma; Glutathione; Humans; Kinetics; Microscopy, Fluorescence; Mitochondria; Molecular Imaging; Oligomycins; Oxidative Stress; Oxygen Consumption; Rotenone; Superoxides; Time Factors | 2018 |
The Mechanism of Action of Ghrelin and Motilin in the Pacemaker Potentials of Interstitial Cells of Cajal from the Murine Small Intestine.
Topics: Acetophenones; Amides; Animals; Benzopyrans; Boron Compounds; Calcium; Carbazoles; Gastrointestinal Motility; Ghrelin; Inositol 1,4,5-Trisphosphate Receptors; Interstitial Cells of Cajal; Intestine, Small; Macrocyclic Compounds; Membrane Potentials; Mice; Mice, Inbred ICR; Motilin; Oligopeptides; Oxazoles; Protein Kinase C; Pyridines; Receptors, Ghrelin; rho-Associated Kinases; Signal Transduction; Staurosporine; Thapsigargin | 2019 |