go 6976 and genistein

Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship

Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases

Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Humans; Models, Biological; Organic Chemicals; Regression Analysis; Support Vector Machine

Topics: Drug Discovery; Organic Chemicals; Pharmaceutical Preparations; Solubility

Topics: Animals; Computer Simulation; Databases, Factual; Drug Discovery; High-Throughput Screening Assays; Liver; Machine Learning; Male; Microsomes, Liver; National Center for Advancing Translational Sciences (U.S.); Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Rats; Rats, Sprague-Dawley; Retrospective Studies; United States

Topics: Animals; Arachidonic Acid; Arachidonic Acids; Biological Transport; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cats; Cells, Cultured; Dose-Response Relationship, Drug; Down-Regulation; Endothelin-1; Genistein; Indoles; Iris; Isoenzymes; Lipoprotein Lipase; Muscle, Smooth; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Protein Kinase C-alpha

Topics: Animals; Aorta, Thoracic; Arteries; Calcium; Carbazoles; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Genistein; In Vitro Techniques; Indoles; Magnesium; Male; Maleimides; Muscle Contraction; Muscle, Smooth, Vascular; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Wistar

Topics: Animals; Benzoquinones; Carbazoles; Enzyme Activation; Enzyme Inhibitors; Extracellular Matrix; Flavonoids; Genistein; Indoles; Lactams, Macrocyclic; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle Tonus; Protein Kinase C; Quinones; Rabbits; Rifabutin; Temperature; Vasoconstriction; Veins

Topics: Amino Acid Sequence; Animals; Brain-Derived Neurotrophic Factor; Carbazoles; DNA, Complementary; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Activation; Enzyme Inhibitors; G Protein-Coupled Inwardly-Rectifying Potassium Channels; Genistein; GTP-Binding Proteins; Indole Alkaloids; Indoles; Lysine; Models, Biological; Molecular Sequence Data; Mutation; Oocytes; Phosphorylation; Potassium Channels; Potassium Channels, Inwardly Rectifying; Precipitin Tests; Receptor, trkB; RNA, Messenger; Staurosporine; Tyrosine; Xenopus

Topics: Apoptosis; Carbazoles; Caspases; Cell Line; DNA Fragmentation; Enzyme Inhibitors; Flow Cytometry; Genistein; Humans; Indoles; Leukemia, Promyelocytic, Acute; Protein Kinase C; Sphingosine

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Vessels; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Genistein; In Vitro Techniques; Indoles; Kidney; Male; Maleimides; Mesentery; Norepinephrine; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Staurosporine; Tyrphostins; Vasoconstriction

Topics: Animals; Calcium Channels, T-Type; Carbazoles; Enzyme Activation; Enzyme Inhibitors; Genistein; Immunoblotting; Indoles; Insulin-Like Growth Factor I; Interleukin-1; Isoenzymes; Male; Maleimides; Manganese; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myocardium; Protein Biosynthesis; Protein Kinase C; Protein Kinase C-alpha; Protein Transport; Rats

Topics: Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents; Carbazoles; Corticosterone; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Immunoblotting; Indoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; PC12 Cells; Phosphorylation; Protein Kinase C; Rats

Topics: Animals; Antioxidants; Blotting, Western; Carbazoles; Cattle; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Fluoresceins; Genistein; Hypoxia; Indoles; Lipid Peroxidation; Lung; Lung Injury; Microcirculation; Models, Biological; Oxygen; Phorbol Esters; Phospholipase D; Phosphorylation; Protein Kinase C; Reactive Oxygen Species; Time Factors

Topics: Acetophenones; Adenosine Triphosphate; Benzopyrans; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; CD18 Antigens; Cell Aggregation; Cycloheximide; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Imidazoles; Indoles; Integrin beta1; Isoenzymes; Maleimides; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Phosphotransferases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Staurosporine; Temperature; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; U937 Cells

Topics: Androstadienes; Animals; Aorta; Calcium; Carbazoles; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Ferrous Compounds; Genistein; Hydrogen Peroxide; Hydroxyl Radical; In Vitro Techniques; Indoles; Male; Maleimides; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphoinositide-3 Kinase Inhibitors; Proadifen; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Staurosporine; Vasoconstriction; Wortmannin