go 6976 and bisindolylmaleimide i

Topics: Azepines; Bryostatins; Carbazoles; Enzyme Inhibitors; Humans; Hydroxybenzoates; Indoles; Lactones; Macrolides; Maleimides; Oligodeoxyribonucleotides, Antisense; Protein Kinase C; Pyrroles; Signal Transduction; Thionucleotides

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides

Topics: Acetylation; Adenosine; Binding Sites; Cell Line, Tumor; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Models, Molecular; Molecular Mimicry; Protein Kinase Inhibitors; Sirtuins; Structure-Activity Relationship; Tubulin

Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases

Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase

Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Humans; Models, Biological; Organic Chemicals; Regression Analysis; Support Vector Machine

Topics: Drug Discovery; Organic Chemicals; Pharmaceutical Preparations; Solubility

Topics: Animals; Computer Simulation; Databases, Factual; Drug Discovery; High-Throughput Screening Assays; Liver; Machine Learning; Male; Microsomes, Liver; National Center for Advancing Translational Sciences (U.S.); Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Rats; Rats, Sprague-Dawley; Retrospective Studies; United States

Topics: Carbazoles; Enzyme Activation; Humans; In Vitro Techniques; Indoles; Isoenzymes; Maleimides; Muramidase; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase C; Respiratory Burst; Superoxides; Tetradecanoylphorbol Acetate

Topics: Animals; Brain; Carbazoles; Cloning, Molecular; Humans; Indoles; Isoenzymes; Kinetics; Maleimides; Mice; Protein Kinase C; Rats; Recombinant Proteins

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Carbachol; Carbazoles; Cholinergic Agents; Coloring Agents; Enzyme Inhibitors; Fura-2; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Male; Maleimides; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Naphthalenes; Pilocarpine; Propylbenzilylcholine Mustard; Protein Kinase C; Receptors, Cholinergic; Sensitivity and Specificity

Topics: Animals; Cadherins; Carbazoles; Cell Adhesion; Cell Movement; Cell Size; Gene Expression Regulation, Neoplastic; Humans; Indoles; Maleimides; Mice; Mice, Nude; Mutagenesis, Site-Directed; Neoplasm Invasiveness; Neoplasms, Experimental; Protein Kinase C; Tetradecanoylphorbol Acetate; Transfection; Transplantation, Heterologous; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator

Topics: Adenylyl Cyclases; Adolescent; Adult; Bronchi; Calcium-Transporting ATPases; Carbazoles; Cilia; Colforsin; Enzyme Inhibitors; Epithelial Cells; Humans; Indoles; Isoenzymes; Kinetics; Lasers; Maleimides; Middle Aged; Naphthalenes; Neuropeptide Y; Protein Kinase C; Scattering, Radiation; Time Factors; Trachea

Topics: Antibodies, Monoclonal; Apoptosis; bcl-X Protein; Carbazoles; Caspase 3; Caspases; Cells, Cultured; Cysteine Endopeptidases; Enzyme Induction; Enzyme Inhibitors; fas Receptor; Humans; Indoles; Maleimides; Protein Kinase C; Proto-Oncogene Proteins c-bcl-2; Sensitivity and Specificity; Subcellular Fractions; T-Lymphocytes

Topics: Caco-2 Cells; Calcitriol; Calcium; Carbazoles; Enzyme Activation; Enzyme Inhibitors; Humans; Indoles; Ionomycin; Isoenzymes; Kinetics; Maleimides; Phospholipase D; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Protein Kinase C-delta; Tetradecanoylphorbol Acetate

Topics: 3T3 Cells; Adenoviridae; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Chromones; DNA Replication; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genes, ras; Genetic Vectors; Indoles; Lymphokines; Maleimides; MAP Kinase Kinase Kinase 1; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Isoforms; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Rats; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin

Topics: Animals; Aorta, Thoracic; Arteries; Calcium; Carbazoles; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Genistein; In Vitro Techniques; Indoles; Magnesium; Male; Maleimides; Muscle Contraction; Muscle, Smooth, Vascular; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Wistar

Topics: Acetophenones; Animals; Benzopyrans; Carbazoles; CHO Cells; Consensus Sequence; Cricetinae; Cyclic AMP; Dogs; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Glioma; Indoles; Isoenzymes; Maleimides; Mutagenesis, Site-Directed; Phosphorylation; Protein Kinase C; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; Signal Transduction; Tetradecanoylphorbol Acetate; Triazines; Triazoles; Tumor Cells, Cultured

Topics: Androstadienes; Carbazoles; CD18 Antigens; Cell Adhesion; Cell Count; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Eosinophils; Humans; Imidazoles; Indoles; Isoenzymes; Macrophage-1 Antigen; Maleimides; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyrazoles; Pyridines; Pyrimidines; Signal Transduction; src-Family Kinases; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin

Topics: Animals; Antibodies; Blood Flow Velocity; Blood Platelets; Blood Proteins; Carbazoles; Carcinogens; Cell Adhesion Molecules; Collagen; Enzyme Inhibitors; Enzyme Precursors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Indoles; Integrins; Intracellular Signaling Peptides and Proteins; Maleimides; Phosphoproteins; Phosphorylation; Platelet Adhesiveness; Protein Conformation; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Receptors, Collagen; Skin; Stimulation, Chemical; Syk Kinase; Tetradecanoylphorbol Acetate; Tyrosine

Topics: Acetophenones; Acetylcholine; Actin Cytoskeleton; Actins; Amino Acid Sequence; Benzopyrans; Biological Transport; Carbachol; Carbazoles; Carcinogens; Cell Membrane; Cell Polarity; Cells, Cultured; Cholinergic Agonists; Cross-Linking Reagents; Cytochalasin D; Diglycerides; Endocytosis; Enzyme Inhibitors; Epithelial Cells; Humans; Indoles; Intestines; Intracellular Signaling Peptides and Proteins; Isoenzymes; Maleimides; Membrane Proteins; Molecular Sequence Data; Myristoylated Alanine-Rich C Kinase Substrate; Nucleic Acid Synthesis Inhibitors; Pinocytosis; Protein Kinase C; Protein Kinase C-epsilon; Proteins; Tetradecanoylphorbol Acetate

Topics: Acetophenones; Benzopyrans; Blood Platelets; Carbazoles; Enzyme Inhibitors; Humans; In Vitro Techniques; Indoles; Isoenzymes; Maleimides; Platelet Activation; Protein Kinase C; Thrombin; Thromboxanes

Topics: Androstadienes; Biological Transport; Carbazoles; Enzyme Activation; Erythrocytes; Humans; Indoles; Insulin; Isoenzymes; Maleimides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein Binding; Protein Kinase C; Protein Kinase C-alpha; Signal Transduction; Sodium-Hydrogen Exchangers; Time Factors; Wortmannin

Topics: Animals; Blood Platelets; Carbazoles; Cattle; Cytoplasmic Granules; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Group IV Phospholipases A2; Humans; Imidazoles; Indoles; Indomethacin; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Aggregation; Protein Kinase C; Protein Processing, Post-Translational; Pyridines; Serotonin; Serum Albumin, Bovine; Thrombin; Thrombopoietin; Thromboxane A2

Topics: Carbazoles; Cell Differentiation; Cell Lineage; Culture Media, Conditioned; Diterpenes; DNA-Binding Proteins; Erythroid-Specific DNA-Binding Factors; Fluorescent Antibody Technique; GATA1 Transcription Factor; Gene Expression Regulation; Genes, Reporter; Humans; Indoles; Isoenzymes; K562 Cells; Maleimides; Megakaryocytes; Mutation; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase C-epsilon; Protein Transport; Response Elements; Signal Transduction; Transcription Factors; Transfection; Tumor Cells, Cultured

Topics: Acetophenones; Animals; Benzopyrans; Carbazoles; Cell Fractionation; Cell Line; Cell Membrane; Endoplasmic Reticulum; Endosomes; Enzyme Inhibitors; Golgi Apparatus; Indoles; Isoenzymes; Lysophospholipids; Maleimides; Mice; Muscle, Skeletal; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Transport; rhoA GTP-Binding Protein; Sphingosine; Tetradecanoylphorbol Acetate

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Vessels; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Genistein; In Vitro Techniques; Indoles; Kidney; Male; Maleimides; Mesentery; Norepinephrine; Protein Kinase C; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Staurosporine; Tyrphostins; Vasoconstriction

Topics: Alkaloids; Animals; Aorta; Benzophenanthridines; Carbazoles; Cells, Cultured; Enzyme Inhibitors; Indoles; Magnesium; Maleimides; Muscle, Smooth, Vascular; Naphthalenes; Phenanthridines; Protein Isoforms; Protein Kinase C; Rats; Staurosporine

Topics: Animals; Blotting, Western; Calcium; Calcium Channel Blockers; Carbazoles; Coronary Vessels; Enzyme Activation; Enzyme Inhibitors; Fura-2; In Vitro Techniques; Indoles; Isoenzymes; Isometric Contraction; Lipoproteins, LDL; Male; Maleimides; Muscle, Smooth, Vascular; Potassium Chloride; Protein Kinase C; Serotonin; Subcellular Fractions; Swine; Tetradecanoylphorbol Acetate; Vasoconstriction; Verapamil

Topics: Androstadienes; Animals; Basilar Artery; Calcium; Carbazoles; Central Nervous System Depressants; Chromones; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Indoles; Male; Maleimides; Morpholines; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Signal Transduction; Stroke; Vasoconstriction; Vasospasm, Intracranial; Wortmannin

Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Androstadienes; Animals; Arachidonic Acid; Arachidonic Acids; Butadienes; Calcium; Carbazoles; Chelating Agents; Chromones; Cyclooxygenase Inhibitors; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; GTP-Binding Protein alpha Subunits, Gi-Go; Heterotrimeric GTP-Binding Proteins; Indoles; Lipoxygenase Inhibitors; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neutrophils; Nitriles; Pertussis Toxin; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Type C Phospholipases; Virulence Factors, Bordetella; Wortmannin

Topics: Amides; Amino Acid Sequence; Animals; Aorta; Carbazoles; Chromatography; Chromatography, Affinity; Chromatography, Ion Exchange; Durapatite; Enzyme Activation; Enzyme Inhibitors; Histamine; In Vitro Techniques; Indoles; Isoenzymes; Kinetics; Maleimides; Molecular Sequence Data; Muscle Contraction; Muscle Proteins; Muscle Relaxants, Central; Muscle, Smooth, Vascular; Myelin Basic Protein; Myosin-Light-Chain Phosphatase; Peptide Fragments; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Pyridines; Recombinant Proteins; Substrate Specificity; Swine; Vasoconstriction

Topics: Acetophenones; Benzopyrans; Bradykinin; Carbazoles; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Immunoblotting; Indoles; Isoenzymes; Kinetics; Maleimides; Phospholipase D; Phospholipids; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

Topics: Animals; Calcium; Carbazoles; Chelating Agents; Conditioning, Classical; Egtazic Acid; Enzyme Inhibitors; Indoles; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Mollusca; Phosphorylation; Serotonin; Tetradecanoylphorbol Acetate

Topics: Carbazoles; Cell Communication; Cells, Cultured; Connexin 43; Dose-Response Relationship, Drug; Gap Junctions; Indoles; Isoenzymes; Maleimides; Protein Kinase C; Protein Kinase C-delta; Protein Kinase C-epsilon; Tetradecanoylphorbol Acetate

Topics: Androstadienes; Animals; Antibodies; Carbazoles; CD18 Antigens; Cell Adhesion; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Eosinophils; Flavonoids; Guinea Pigs; Imidazoles; Indoles; Integrin beta1; Intracellular Signaling Peptides and Proteins; Leukotriene B4; Macrophage-1 Antigen; Male; Maleimides; Mitogen-Activated Protein Kinases; NADPH Oxidases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein-Tyrosine Kinases; Pyrazoles; Pyridines; Pyrimidines; Rats; src-Family Kinases; Stilbenes; Syk Kinase; Time Factors; Wortmannin

Topics: Alternative Splicing; Carbazoles; Catalytic Domain; Enzyme Inhibitors; Female; HeLa Cells; Humans; Indoles; Maleimides; Protein Kinase C; RNA, Messenger; Telomerase; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Uterine Cervical Neoplasms

Topics: Carbazoles; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Humans; Immunoglobulin G; Indoles; Maleimides; Microscopy, Fluorescence; NADPH Oxidases; Neutrophils; Oligonucleotides, Antisense; Oxygen; Oxygen Consumption; Phagocytosis; Phosphoproteins; Phosphorylation; Protein Kinase C; Receptors, IgG; Recombinant Proteins; Signal Transduction; Staphylococcus aureus

Topics: Acetophenones; Benzopyrans; Carbazoles; Collagenases; Enzyme Inhibitors; Fibroblast Growth Factor 2; Genes, Dominant; Humans; Indoles; Maleimides; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Models, Biological; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-raf; ras Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured

Topics: Apoptosis; Carbazoles; Caspase 8; Caspase 9; Caspases; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Fas Ligand Protein; fas Receptor; Gene Expression Regulation, Leukemic; Humans; I-kappa B Proteins; Indoles; Isoenzymes; Jurkat Cells; Maleimides; Membrane Glycoproteins; Neoplasm Proteins; NF-kappa B; NF-KappaB Inhibitor alpha; Protein Kinase C; Recombinant Fusion Proteins; Sequence Deletion; Tetradecanoylphorbol Acetate

Topics: Acetophenones; Animals; Benzopyrans; Calcium; Carbazoles; Cell Line; Enzyme Inhibitors; Epidermal Growth Factor; Gene Expression Regulation; Indoles; Isoenzymes; Maleimides; Naphthalenes; Phorbol Esters; Pituitary Gland; Prolactin; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase C-delta; Protein Kinase C-epsilon; Rats; Staurosporine; Thyrotropin-Releasing Hormone; Transcription, Genetic

Topics: Acetophenones; Adenosine Triphosphate; Benzopyrans; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; CD18 Antigens; Cell Aggregation; Cycloheximide; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Humans; Imidazoles; Indoles; Integrin beta1; Isoenzymes; Maleimides; Mitogen-Activated Protein Kinases; Naphthalenes; Phosphorylation; Phosphotransferases; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Staurosporine; Temperature; Tetradecanoylphorbol Acetate; Time Factors; Tyrosine; U937 Cells

Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Astrocytes; Blotting, Northern; Blotting, Western; Brain; Carbazoles; Cell Line; Dose-Response Relationship, Drug; Flavonoids; Gene Expression; Indoles; Kinetics; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase C; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X4; Receptors, Purinergic P2X7; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetradecanoylphorbol Acetate; Transforming Growth Factor beta; Transforming Growth Factor beta1

Topics: Adult; Blotting, Western; Calcium; Carbazoles; Enzyme Activators; Enzyme Inhibitors; Female; Humans; Indoles; Intracellular Signaling Peptides and Proteins; Isoenzymes; Maleimides; Muscle Contraction; Muscle Proteins; Myometrium; Myosin Light Chains; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Pregnancy; Pregnancy Trimester, Third; Protein Kinase C; RNA, Messenger; Serine; Type C Phospholipases; Uterine Contraction

Topics: Animals; Bacterial Proteins; Bile; Biological Transport; Blotting, Western; Calcium; Carbazoles; Cell Line; Cell Membrane; Cells, Cultured; Cholestasis; Cloning, Molecular; Densitometry; Detergents; Dose-Response Relationship, Drug; Enzyme Activation; Hepatocytes; Humans; Indoles; Liver; Luminescent Proteins; Male; Maleimides; Microscopy, Confocal; Models, Biological; Perfusion; Phorbol Esters; Polymerase Chain Reaction; Protein Isoforms; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Protein Transport; Rats; Rats, Wistar; Signal Transduction; Taurocholic Acid; Tetradecanoylphorbol Acetate; Time Factors; Transfection

Topics: Animals; Carbazoles; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Membrane; Cytoplasm; Humans; Indoles; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; Maleimides; Mice; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; rac1 GTP-Binding Protein; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

Topics: Adenoviridae; Angiopoietin-2; Animals; Blotting, Northern; Blotting, Western; Butadienes; Carbazoles; Cattle; Cell Division; Disease Models, Animal; DNA; Enzyme Inhibitors; Flavonoids; Genes, Dominant; Humans; Hypoxia; Indoles; Maleimides; Mice; Models, Biological; Neovascularization, Pathologic; Neuropilin-1; Nitriles; Phosphorylation; Proto-Oncogene Protein c-ets-1; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ets; Reperfusion Injury; Retina; RNA, Messenger; Staurosporine; Time Factors; Transcription Factors; Up-Regulation; Vascular Endothelial Growth Factor A

Topics: Animals; Carbazoles; Caspase 3; Caspases; CDC2 Protein Kinase; Cell Cycle; Cell Death; Cyclin A; Cyclin B; Cyclin B1; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; G2 Phase; Genes, Tumor Suppressor; Humans; Immediate-Early Proteins; Indoles; Maleimides; Mice; NIH 3T3 Cells; Nocodazole; Protein Binding; Protein Kinase C; Protein Kinase C-delta; Pyridines; Retinoblastoma Protein; RNA, Messenger; Signal Transduction; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; U937 Cells

Topics: Androstadienes; Animals; Aorta; Calcium; Carbazoles; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Ferrous Compounds; Genistein; Hydrogen Peroxide; Hydroxyl Radical; In Vitro Techniques; Indoles; Male; Maleimides; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphoinositide-3 Kinase Inhibitors; Proadifen; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Staurosporine; Vasoconstriction; Wortmannin

Topics: Calcium; Carbazoles; Cations; Cell Line; Culture Media, Serum-Free; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Humans; Immunoblotting; Indoles; Maleimides; Neomycin; Protein Isoforms; Protein Kinase C; Protein Kinase C-epsilon; Receptors, Calcium-Sensing; Signal Transduction; Subcellular Fractions; Tetradecanoylphorbol Acetate; Time Factors

Topics: Actin Cytoskeleton; Actins; Albumins; Animals; Carbazoles; Endocytosis; Endothelial Cells; Enzyme Inhibitors; Indoles; Kidney Tubules, Proximal; Maleimides; Opossums; Protein Kinase C; Protein Kinase C-alpha; Transfection

Topics: Alcohol Drinking; Alkaloids; Animals; Benzophenanthridines; Carbazoles; Cell Adhesion; Enzyme Inhibitors; Indoles; Intestine, Small; Ischemia; Leukocyte Rolling; Leukocytes; Maleimides; Mice; Mice, Inbred Strains; P-Selectin; Phenanthridines; Protein Kinase C; Time Factors

Topics: Acetophenones; Animals; Benzopyrans; Calcium; Calcium Channel Blockers; Calcium Signaling; Carbazoles; Cell Line; Cell Survival; Chelating Agents; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Indoles; Intestinal Mucosa; Intracellular Space; Maleimides; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Kinase C-epsilon; Tetradecanoylphorbol Acetate; Verapamil

Topics: Activating Transcription Factor 2; Animals; Atrial Natriuretic Factor; Carbazoles; Cardiomegaly; Cyclic AMP Response Element-Binding Protein; Gene Expression; Gene Expression Regulation; Indoles; Maleimides; MAP Kinase Kinase Kinases; Myocytes, Cardiac; Myosin Heavy Chains; Natriuretic Peptide, Brain; Promoter Regions, Genetic; Protein Kinase C; Rats; RNA, Messenger; Transcription Factors; Transcriptional Activation; Transforming Growth Factor beta; Transforming Growth Factor beta1

Topics: Acetophenones; Animals; Benzopyrans; Calcium; Carbazoles; Cell Line; Dogs; Enzyme Inhibitors; Indoles; Isoenzymes; Kidney Tubules; Maleimides; Membrane Proteins; Occludin; Permeability; Protein Kinase C; Tight Junctions

Topics: Acetophenones; Animals; Benzopyrans; Blotting, Western; Calcimycin; Calcium; Carbazoles; Female; In Vitro Techniques; Indoles; Ionophores; Isoenzymes; Maleimides; Oocytes; Protein Kinase C; Protein Kinase Inhibitors; Pyrones; Swine

Topics: Animals; Bradykinin; Carbazoles; Cattle; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Indoles; Isoenzymes; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Smooth Muscle; Protein Kinase C; Receptor, Bradykinin B2; Tetradecanoylphorbol Acetate; Thymidine; Trachea; Tritium

Topics: Animals; Blotting, Western; C-Peptide; Carbazoles; Cyclooxygenase 2; Fibroblasts; I-kappa B Proteins; Indoles; Luciferases; Maleimides; Mice; NF-kappa B; Nitriles; Phosphorylation; Plasmids; Proinsulin; Promoter Regions, Genetic; Protein Kinase C; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sulfones; Swiss 3T3 Cells; Transcription, Genetic; Transfection

Topics: ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Carbazoles; Cells, Cultured; Down-Regulation; Humans; Indoles; Isoenzymes; Liver; Maleimides; Protein Kinase C; Protein Kinase C beta; Tetradecanoylphorbol Acetate

Topics: Animals; Carbazoles; Carbon Dioxide; Carbon Radioisotopes; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Enzyme Inhibitors; Green Fluorescent Proteins; Immunoblotting; Indoles; Maleimides; Membrane Potentials; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Mitochondria; Muscle Cells; Phorbol Esters; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Transport; Pyruvate Dehydrogenase Complex; Reactive Oxygen Species; Recombinant Fusion Proteins

Topics: Adenosine Triphosphate; Animals; Barium; Biological Transport, Active; Calcium; Carbazoles; Cell Line; Enzyme Activation; Indoles; Maleimides; Manganese; Microscopy, Fluorescence; Protein Kinase C; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Tetradecanoylphorbol Acetate; Thapsigargin; Thyroid Gland; Uridine Triphosphate

Topics: Animals; beta-Glucans; Carbazoles; Estrenes; Extracellular Signal-Regulated MAP Kinases; Glucans; Hemocytes; Hydrogen Peroxide; Indoles; Lymnaea; Maleimides; Phosphatidylinositol 3-Kinases; Phospholipid Ethers; Phosphorylation; Polysaccharides; Protein Kinase C; Protein Kinase Inhibitors; Pyrrolidinones; Reactive Oxygen Species; Signal Transduction

Topics: Alkaloids; Animals; Benzophenanthridines; Calcium Channel Blockers; Calcium Channels, L-Type; Carbazoles; Coronary Vessels; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; In Vitro Techniques; Indoles; Male; Maleimides; Membrane Potentials; Nifedipine; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Phorbol 12,13-Dibutyrate; Pinacidil; Potassium; Protein Kinase C; Protein Kinase Inhibitors; Rabbits; Vasoconstriction; Vasodilator Agents

Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Binding, Competitive; Carbazoles; Cell Membrane; Chlorocebus aethiops; COS Cells; Diglycerides; Estrenes; HeLa Cells; HL-60 Cells; Humans; Indoles; Maleimides; Membranes; Microscopy, Confocal; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein Transport; Pyrrolidinones; Staurosporine

Topics: Carbazoles; Cell Differentiation; Cell Line, Tumor; Humans; Indoles; K562 Cells; Leukemia, Myeloid; Maleimides; Megakaryocytes; Mitogen-Activated Protein Kinases; Nuclear Proteins; Nucleolin; Nucleophosmin; Phosphoproteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinase C; RNA-Binding Proteins; Tetradecanoylphorbol Acetate

Topics: Acetophenones; Agaricales; Animals; Anti-Inflammatory Agents; Antioxidants; Benzopyrans; Carbazoles; Cell Line; Dose-Response Relationship, Drug; Heme Oxygenase-1; Immunoblotting; Indoles; Lipopolysaccharides; Luciferases; Macrophages; Maleimides; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; NF-E2-Related Factor 2; Nitric Oxide; Nitric Oxide Synthase Type II; Protein Kinase C-delta; Response Elements; Signal Transduction; Transcription, Genetic; Transfection; Up-Regulation

Topics: Adaptor Proteins, Signal Transducing; Base Sequence; Calcimycin; Calcineurin; Calcineurin Inhibitors; Carbazoles; DNA Primers; Enzyme Activation; Humans; In Vitro Techniques; Indoles; Ionophores; Isoenzymes; Leukocytes, Mononuclear; Maleimides; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate

Topics: Adaptation, Physiological; Animals; Binding Sites; Bone Marrow Cells; Carbazoles; Chemokine CCL2; Dose-Response Relationship, Drug; Enzyme Activation; Exocytosis; Immunity, Innate; Immunoglobulin E; Indoles; Ligands; Lipopeptides; Maleimides; Mast Cells; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Peptides; Phosphorylation; Protein Kinase C; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Stem Cell Factor; Structure-Activity Relationship

Topics: Carbazoles; Cell Line, Tumor; Enzyme Inhibitors; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Histone Deacetylase Inhibitors; Humans; Indoles; Maleimides; Nuclear Transfer Techniques; Promoter Regions, Genetic; Protein Kinase C; Protein Kinase C-delta; Trans-Activators; Transcriptional Activation; Viral Proteins; Virus Activation

Topics: Animals; Carbazoles; Cells, Cultured; Fibroblast Growth Factor 2; Indoles; Interleukin-6; Maleimides; Mice; Osteoblasts; Phosphorylation; Protein Kinase C; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Tetradecanoylphorbol Acetate

Topics: Adaptor Proteins, Signal Transducing; Adipose Tissue; Animals; Blotting, Western; Butadienes; Carbazoles; CHO Cells; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glycogen Synthase Kinase 3; Indoles; Insulin Receptor Substrate Proteins; Maleimides; Mice; Mice, Inbred C57BL; Mice, Obese; Nitriles; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Protein Kinase Inhibitors; Transfection

Topics: Animals; Apoptosis; Carbazoles; Cytoprotection; DNA Damage; Enzyme Activation; Indoles; Maleimides; Methylnitronitrosoguanidine; Mice; Necrosis; Phorbol Esters; Phosphorylation; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Kinase C; Protein Kinase Inhibitors; Thymus Gland

Topics: Acetophenones; Acetylcholine; Animals; Benzopyrans; Bronchi; Carbazoles; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indoles; Isoenzymes; Male; Maleimides; Muscle Contraction; Muscle, Smooth; Protein Kinase C-epsilon; Rats; Rats, Wistar

Topics: Acetophenones; Animals; Benzopyrans; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cells, Cultured; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Genes, Dominant; Humans; Indoles; Lipopolysaccharides; Macrophages; Maleimides; Mice; Monocytes; Phosphorylation; Protein Kinase C-delta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transcription, Genetic; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-1

Topics: Animals; Carbazoles; Cell Line; Flavonoids; HSP70 Heat-Shock Proteins; Humans; Indoles; Isoquinolines; Maleimides; MAP Kinase Signaling System; Mice; NFATC Transcription Factors; Phosphorylation; Promoter Regions, Genetic; Protein Kinase C; Protein Transport; Saline Solution, Hypertonic; Signal Transduction; Sulfonamides

Topics: Acetophenones; Adrenergic Agents; Animals; Benzopyrans; Carbazoles; Cell Survival; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Indoles; Maleimides; Oxidopamine; PC12 Cells; Phorbol Esters; Phosphorylation; Protein Kinase C; Rats; Time Factors

Topics: Animals; Carbazoles; Caveolae; Cell Line; Endosomes; Gene Knockdown Techniques; Half-Life; Humans; Indoles; Isoenzymes; Maleimides; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Transport; Proteolysis; Rats; Receptors, Transforming Growth Factor beta; RNA Interference; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta

Topics: Androstadienes; Carbazoles; Cell Line, Tumor; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Fibroblast Growth Factors; Humans; Indoles; Insulin Receptor Substrate Proteins; Maleimides; Phosphatidylinositol 3-Kinase; Protein Kinase C; Signal Transduction; Somatomedins; Wortmannin

Topics: Carbazoles; Cells, Cultured; Electromagnetic Fields; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Humans; In Vitro Techniques; Indoles; Male; Maleimides; Mucociliary Clearance; Naphthalenes; Nasal Mucosa; Protein Kinase C; Statistics, Nonparametric

Topics: Activins; Alkaline Phosphatase; Blotting, Western; Carbazoles; Cell Line; Cell Proliferation; Chromones; Extracellular Signal-Regulated MAP Kinases; Fibroblast Growth Factor 2; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Immunohistochemistry; Indoles; Maleimides; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Pluripotent Stem Cells; Protein Kinase C; Protein Kinase C-delta; Protein Kinase C-epsilon; Proto-Oncogene Proteins c-akt; RNA Interference; Signal Transduction; Tetradecanoylphorbol Acetate

Topics: Apoptosis; Aurora Kinase A; Aurora Kinases; Carbazoles; Caspase 3; Caspase 8; Cell Cycle; Cell Line; Cell Survival; Humans; Imidazoles; Indoles; Maleimides; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Mas; Pyridines; Transfection

Topics: Antibodies; Arthroplasty, Replacement, Knee; Carbazoles; Cartilage, Articular; Enzyme Inhibitors; Fibroblasts; Gene Expression Regulation; Heme Oxygenase-1; Humans; Indoles; Maleimides; MicroRNAs; Osteoarthritis; Phospholipases; Primary Cell Culture; Protein Kinase C-alpha; Recombinant Proteins; RNA, Small Interfering; Signal Transduction; Synovial Membrane; Transforming Growth Factor beta1