go 6976 has been researched along with 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (9.52) | 18.2507 |
| 2000's | 16 (76.19) | 29.6817 |
| 2010's | 3 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caivano, M; Cohen, P; Davies, SP; Reddy, H | 1 |
| Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H | 1 |
| Giranda, VL; Johnson, EF; Luo, Y; Stewart, KD; Woods, KW | 1 |
| Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N | 1 |
| Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M | 1 |
| Hajduk, PJ; Johnson, EF; Kifle, L; Merta, PJ; Metz, JT; Soni, NB | 1 |
| Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A | 1 |
| Solem, ML; Thomas, AP | 1 |
| Shibuya, M; Takahashi, T; Ueno, H | 1 |
| Altura, BM; Altura, BT; Wang, J; Yang, ZW; Zheng, T | 2 |
| Garcia, I; Guerne, PA; Guicheux, J; Lubberts, E; Mezin, F; Relic, B; Togninalli, D; van den Berg, WB | 1 |
| Barnard, EA; Cousens, DJ; Humphrey, PP; Lundahl, TS; Sellers, LA; Simon, J | 1 |
| Chang, LC; Wang, JP | 1 |
| Cueff, A; De Cian, MC; Lacoste, A; Poulet, SA | 1 |
| Blomhoff, HK; Myklebust, JH; Rusten, LS; Smeland, EB; Stokke, T | 1 |
| Anel, A; Boyer, C; Buferne, M; Martínez-Lorenzo, MJ; Naval, J; Pardo, J; Schmitt-Verhulst, AM | 1 |
| Callaghan, B; Keef, KD; Koh, SD | 1 |
| Hirata Terra, J; Millward, TA; Montaño, I; Schilb, A | 1 |
| Fujikake, T; Fujioka, K; Hanamoto, T; Ikeda, T; Ishizuka, T; Kajita, K; Mori, I; Morita, H; Nagano, I; Okada, H; Takahashi, Y; Uno, Y; Zhiliang, W | 1 |
| Furue, MK; Hirata, M; Hirayama, N; Kawamura, S; Kinehara, M; Kohara, A; Matsumura, H; Mimura, S; Suga, M; Tateyama, D; Uchio-Yamada, K; Yanagihara, K | 1 |
21 other study(ies) available for go 6976 and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one
| Article | Year |
|---|---|
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides | 2000 |
Identifying off-target effects and hidden phenotypes of drugs in human cells.
Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship | 2006 |
Pharmacological and functional comparison of the polo-like kinase family: insight into inhibitor and substrate specificity.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Androstadienes; Binding Sites; Cell Cycle Proteins; Humans; Models, Molecular; Molecular Sequence Data; Peptide Library; Polo-Like Kinase 1; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Pteridines; Substrate Specificity; Wortmannin | 2007 |
The selectivity of protein kinase inhibitors: a further update.
Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera | 2007 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases | 2007 |
Navigating the kinome.
Topics: Drug Design; Pharmacogenetics; Protein Kinases; Proteome; Systems Biology | 2011 |
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase | 2013 |
Modulation of cardiac Ca2+ channels by IGF1.
Topics: Animals; Calcium; Calcium Channels; Carbazoles; Cells, Cultured; Chromones; Cytosol; Enzyme Inhibitors; Heart; Humans; Indoles; Insulin-Like Growth Factor I; Isoquinolines; Kinetics; Male; Manganese; Morpholines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sarcolemma; Sulfonamides; Tetradecanoylphorbol Acetate | 1998 |
VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells.
Topics: 3T3 Cells; Adenoviridae; Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Chromones; DNA Replication; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genes, ras; Genetic Vectors; Indoles; Lymphokines; Maleimides; MAP Kinase Kinase Kinase 1; Mice; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Isoforms; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Rats; Receptor Protein-Tyrosine Kinases; Receptors, Growth Factor; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin | 1999 |
Low [Mg(2+)](o) induces contraction and [Ca(2+)](i) rises in cerebral arteries: roles of ca(2+), PKC, and PI3.
Topics: Androstadienes; Animals; Anticoagulants; Basilar Artery; Caffeine; Calcium; Carbazoles; Chromones; Dogs; Enzyme Inhibitors; Extracellular Space; Heparin; In Vitro Techniques; Indoles; Magnesium; Maleimides; Morpholines; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Ryanodine; Signal Transduction; Thapsigargin; Vasoconstriction; Wortmannin | 2000 |
Il-4 and IL-13, but not IL-10, protect human synoviocytes from apoptosis.
Topics: Adjuvants, Immunologic; Apoptosis; Arthritis, Rheumatoid; Carbazoles; Chromones; Culture Techniques; Down-Regulation; Enzyme Inhibitors; Humans; Immunosuppressive Agents; Indoles; Insulin-Like Growth Factor I; Interleukin-10; Interleukin-13; Interleukin-4; Morpholines; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Osteoarthritis; Protein Kinase C; Synovial Membrane | 2001 |
Adenosine nucleotides acting at the human P2Y1 receptor stimulate mitogen-activated protein kinases and induce apoptosis.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Annexin A5; Apoptosis; Astrocytoma; Carbachol; Carbazoles; Chromones; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; ets-Domain Protein Elk-1; GTP-Binding Proteins; Humans; Indoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Proto-Oncogene Proteins; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Recombinant Proteins; Thionucleotides; Transcription Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella | 2001 |
Importance of PKC and PI3Ks in ethanol-induced contraction of cerebral arterial smooth muscle.
Topics: Androstadienes; Animals; Basilar Artery; Calcium; Carbazoles; Central Nervous System Depressants; Chromones; Dogs; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Indoles; Male; Maleimides; Morpholines; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Signal Transduction; Stroke; Vasoconstriction; Vasospasm, Intracranial; Wortmannin | 2001 |
Signal transduction pathways for activation of extracellular signal-regulated kinase by arachidonic acid in rat neutrophils.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Androstadienes; Animals; Arachidonic Acid; Arachidonic Acids; Butadienes; Calcium; Carbazoles; Chelating Agents; Chromones; Cyclooxygenase Inhibitors; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; GTP-Binding Protein alpha Subunits, Gi-Go; Heterotrimeric GTP-Binding Proteins; Indoles; Lipoxygenase Inhibitors; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neutrophils; Nitriles; Pertussis Toxin; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Type C Phospholipases; Virulence Factors, Bordetella; Wortmannin | 2001 |
Noradrenaline and alpha-adrenergic signaling induce the hsp70 gene promoter in mollusc immune cells.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Carbazoles; Chromones; Enzyme Inhibitors; Estrenes; Flavonoids; Gene Expression Regulation; Hemocytes; HSP70 Heat-Shock Proteins; Indoles; Isoproterenol; Isoquinolines; Luciferases; Morpholines; Naphthalenes; Norepinephrine; Ostreidae; Pertussis Toxin; Phenylephrine; Phosphodiesterase Inhibitors; Prazosin; Promoter Regions, Genetic; Propranolol; Pyrrolidinones; Signal Transduction; Sulfonamides; Transfection; Virulence Factors, Bordetella | 2001 |
Activation of phosphatidylinositol 3-kinase is important for erythropoietin-induced erythropoiesis from CD34(+) hematopoietic progenitor cells.
Topics: Adult; Antigens, CD34; Antigens, Differentiation; Butadienes; Carbazoles; Cell Cycle; Cell Differentiation; Cell Division; Cells, Cultured; Chromones; Enzyme Activation; Enzyme Inhibitors; Erythroid Precursor Cells; Erythropoiesis; Erythropoietin; Flavonoids; Glycophorins; Hematopoietic Stem Cells; Humans; Indoles; Isoenzymes; Morpholines; Naphthalenes; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Kinase C-alpha; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Recombinant Proteins; Staurosporine; Stem Cell Factor | 2002 |
Differential implication of protein kinase C isoforms in cytotoxic T lymphocyte degranulation and TCR-induced Fas ligand expression.
Topics: Acetophenones; Androstadienes; Animals; Antibodies, Monoclonal; Benzopyrans; Carbazoles; Cell Degranulation; Cell Line; Chromones; Cycloheximide; Cytotoxicity, Immunologic; Dactinomycin; Fas Ligand Protein; Humans; Indoles; Ionomycin; Isoenzymes; Jurkat Cells; Luciferases; Lymphocyte Activation; Membrane Glycoproteins; Mice; Morpholines; Perforin; Phorbol Esters; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pore Forming Cytotoxic Proteins; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Protein Kinase C-theta; Receptor-CD3 Complex, Antigen, T-Cell; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes, Cytotoxic; Transfection; Wortmannin | 2003 |
Muscarinic M2 receptor stimulation of Cav1.2b requires phosphatidylinositol 3-kinase, protein kinase C, and c-Src.
Topics: Acetylcholine; Animals; Barium; Calcium Channels, L-Type; Carbazoles; Cells, Cultured; Chromones; Class Ib Phosphatidylinositol 3-Kinase; Diamines; Enzyme Inhibitors; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; Indoles; Ion Channel Gating; Ion Transport; Isoenzymes; Male; Morpholines; Muscarinic Agonists; Muscarinic Antagonists; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Naphthalenes; Patch-Clamp Techniques; Phorbol 12,13-Dibutyrate; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Portal Vein; Protein Kinase C; Proto-Oncogene Proteins pp60(c-src); Pyrimidines; Rabbits; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Signal Transduction | 2004 |
Development of a microplate bioassay for monocyte chemoattractant protein-1 based on activation of p44/42 mitogen-activated protein kinase.
Topics: Amides; Animals; Antibodies, Monoclonal; Biological Assay; Carbazoles; Cell Line; Chemokine CCL2; Chromones; Cricetinae; DNA, Complementary; Enzyme Inhibitors; Indoles; Microchemistry; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Phosphorylation; Promoter Regions, Genetic; Pyridines; Receptors, CCR2; Receptors, Chemokine; Transfection | 2004 |
Effects of phorbol ester-sensitive PKC (c/nPKC) activation on the production of adiponectin in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Angiotensin II; Animals; Benzimidazoles; Biphenyl Compounds; Carbazoles; Chromones; Enzyme Activation; Gene Expression; Glucose; Insulin; Mice; Morpholines; NF-kappa B; PPAR gamma; Protein Kinase C; Tetradecanoylphorbol Acetate; Tetrazoles; Tumor Necrosis Factor-alpha | 2009 |
Protein kinase C regulates human pluripotent stem cell self-renewal.
Topics: Activins; Alkaline Phosphatase; Blotting, Western; Carbazoles; Cell Line; Cell Proliferation; Chromones; Extracellular Signal-Regulated MAP Kinases; Fibroblast Growth Factor 2; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Immunohistochemistry; Indoles; Maleimides; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Pluripotent Stem Cells; Protein Kinase C; Protein Kinase C-delta; Protein Kinase C-epsilon; Proto-Oncogene Proteins c-akt; RNA Interference; Signal Transduction; Tetradecanoylphorbol Acetate | 2013 |