glyoxamide has been researched along with neocryptolepine* in 1 studies
1 other study(ies) available for glyoxamide and neocryptolepine
| Article | Year |
|---|---|
Formation of N-heterocycles by the reaction of thiols with glyoxamides: exploring a connective Pummerer-type cyclisation.
The reaction of thiols with glyoxamides provides a convenient method for the generation of thionium ions and the initiation of Pummerer-type reactions. When the glyoxamides contain tethered aromatic nucleophiles, N-heterocycles are formed by a thionium ion cyclisation. The scope and mechanism of the connective Pummerer-type process has been investigated using a range of thiols, Lewis acids and both mono- and bis-glyoxamides. The utility of the process has been illustrated in a synthesis of the indoloquinoline natural product, neocryptolepine. Topics: Alkaloids; Biological Products; Cyclization; Feasibility Studies; Heterocyclic Compounds; Pharmaceutical Preparations; Quinolines; Sulfhydryl Compounds; Sulfonylurea Compounds | 2009 |