glyoxamide and diphenyl

There has been an increasing interest in the development of antimicrobial peptides (AMPs) and their synthetic mimics as a novel class of antibiotics to overcome the rapid emergence of antibiotic resistance. Recently, phenylglyoxamide-based small molecular AMP mimics have been identified as potential leads to treat bacterial infections. In this study, a new series of biphenylglyoxamide-based small molecular AMP mimics were synthesised from the ring-opening reaction of

Topics: Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Biofilms; Biphenyl Compounds; Cell Line; Drug Design; Escherichia coli; Fibroblasts; Humans; Lipid Bilayers; Membrane Potentials; Microbial Sensitivity Tests; Molecular Structure; Peptidomimetics; Staphylococcus aureus; Structure-Activity Relationship; Sulfonylurea Compounds