Compounds > glycylsarcosine
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glycylsarcosine and valacyclovir

glycylsarcosine has been researched along with valacyclovir in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (46.15)18.2507
2000's4 (30.77)29.6817
2010's3 (23.08)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ganapathy, ME; Ganapathy, V; Huang, W; Leibach, FH; Wang, H1
Amidon, GL; Covitz, KM; de Vrueh, RL; Han, H; Lee, CP; Oh, DM; Rhie, JK; Sadée, W; Smith, PL1
Balimane, PV; Guo, A; Kitada, H; Leibach, FH; Nakanishi, T; Sinko, PJ; Tamai, I; Tsuji, A1
Balimane, PV; Guo, A; Hu, P; Leibach, FH; Sinko, PJ1
Hashimoto, Y; Inui, KI; Saito, H; Sawada, K; Terada, T1
Artursson, P; Bergström, CA; Matsson, P; Nagahara, N; Norinder, U; Tavelin, S1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Amidon, GL; Han, HK; Oh, DM1
Inui, K; Irie, M; Saito, H; Sawada, K; Terada, T1
Amidon, GL; Chu, X; Fleisher, D; Komorowski, TE; Landowski, CP; Sun, D; Wallsten, R1
Atluri, H; Dias, C; Mitra, A; Nashed, Y1
Smith, DE; Yang, B1

Reviews

1 review(s) available for glycylsarcosine and valacyclovir

ArticleYear
Membrane transporters in drug development.
    Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3

    Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs

2010

Other Studies

12 other study(ies) available for glycylsarcosine and valacyclovir

ArticleYear
Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2.
    Biochemical and biophysical research communications, 1998, May-19, Volume: 246, Issue:2

    Topics: Acyclovir; Animals; Antiviral Agents; Biological Transport, Active; Caco-2 Cells; Carrier Proteins; Cell Line; Dipeptides; HeLa Cells; Humans; Intestinal Mucosa; Kidney; Kinetics; Peptide Transporter 1; Prodrugs; Rats; Recombinant Proteins; Symporters; Valacyclovir; Valine

1998
5'-Amino acid esters of antiviral nucleosides, acyclovir, and AZT are absorbed by the intestinal PEPT1 peptide transporter.
    Pharmaceutical research, 1998, Volume: 15, Issue:8

    Topics: Acyclovir; Animals; Antiviral Agents; Biological Availability; Caco-2 Cells; Carrier Proteins; CHO Cells; Cricetinae; Esters; Humans; Intestinal Absorption; Intestinal Mucosa; Peptide Transporter 1; Rats; Symporters; Zidovudine

1998
Direct evidence for peptide transporter (PepT1)-mediated uptake of a nonpeptide prodrug, valacyclovir.
    Biochemical and biophysical research communications, 1998, Sep-18, Volume: 250, Issue:2

    Topics: Acyclovir; Animals; Biological Transport; Carrier Proteins; Female; Gene Expression; Humans; Oocytes; Peptide Transporter 1; Prodrugs; RNA, Complementary; Symporters; Valacyclovir; Valine; Xenopus laevis

1998
Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell line.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:1

    Topics: Acyclovir; Animals; Anti-Bacterial Agents; Antiviral Agents; Biological Transport; Caco-2 Cells; Carrier Proteins; CHO Cells; Cricetinae; Dipeptides; Humans; Hydrogen-Ion Concentration; Kinetics; Lactams; Peptide Transporter 1; Rabbits; Rats; Symporters; Transfection; Valacyclovir; Valine

1999
Recognition of L-amino acid ester compounds by rat peptide transporters PEPT1 and PEPT2.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:2

    Topics: Acyclovir; Amino Acids; Animals; Carrier Proteins; Dipeptides; Dose-Response Relationship, Drug; LLC-PK1 Cells; Prodrugs; Rats; Swine; Transfection; Valacyclovir; Valine

1999
Exploring the role of different drug transport routes in permeability screening.
    Journal of medicinal chemistry, 2005, Jan-27, Volume: 48, Issue:2

    Topics: Administration, Oral; Biological Transport; Caco-2 Cells; Cell Line; Humans; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Membranes, Artificial; Models, Biological; Molecular Conformation; Monte Carlo Method; Permeability; Pharmaceutical Preparations; Pharmacokinetics

2005
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Cellular uptake mechanism of amino acid ester prodrugs in Caco-2/hPEPT1 cells overexpressing a human peptide transporter.
    Pharmaceutical research, 1998, Volume: 15, Issue:9

    Topics: Acyclovir; Amino Acids; Anti-HIV Agents; Antiviral Agents; Binding, Competitive; Biological Transport; Caco-2 Cells; Cadherins; Carrier Proteins; Dipeptides; Esters; Humans; Hydrolysis; Kinetics; Membrane Transport Proteins; Prodrugs; Valacyclovir; Valine; Zidovudine

1998
Recognition and transport characteristics of nonpeptidic compounds by basolateral peptide transporter in Caco-2 cells.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 298, Issue:2

    Topics: Acyclovir; Aminolevulinic Acid; Antiviral Agents; ATP-Binding Cassette Transporters; Caco-2 Cells; Carrier Proteins; Diethyl Pyrocarbonate; Dipeptides; Humans; Peptide Transporter 1; Photosensitizing Agents; Symporters; Valacyclovir; Valine

2001
Drug inhibition of Gly-Sar uptake and hPepT1 localization using hPepT1-GFP fusion protein.
    AAPS pharmSci, 2001, Volume: 3, Issue:1

    Topics: Acyclovir; Blotting, Western; Caco-2 Cells; Carrier Proteins; Cell Membrane; Cephalexin; Depression, Chemical; Dipeptides; Green Fluorescent Proteins; HeLa Cells; Humans; Luminescent Proteins; Microscopy, Confocal; Peptide Transporter 1; Recombinant Fusion Proteins; Subcellular Fractions; Symporters; Transfection; Valacyclovir; Valine

2001
Ocular penetration of acyclovir and its peptide prodrugs valacyclovir and val-valacyclovir following systemic administration in rabbits: An evaluation using ocular microdialysis and LC-MS.
    Current eye research, 2002, Volume: 25, Issue:4

    Topics: Acyclovir; Animals; Antiviral Agents; Aqueous Humor; Area Under Curve; Chromatography, Liquid; Dipeptides; Evaluation Studies as Topic; Eye; Male; Mass Spectrometry; Microdialysis; Models, Animal; Ocular Physiological Phenomena; Prodrugs; Rabbits; Time Factors; Tritium; Valacyclovir; Valine; Vitreous Body

2002
Significance of peptide transporter 1 in the intestinal permeability of valacyclovir in wild-type and PepT1 knockout mice.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:3

    Topics: Acyclovir; Administration, Oral; Animals; Antiviral Agents; Binding, Competitive; Biotransformation; Cefadroxil; Chromatography, High Pressure Liquid; Colon; Dipeptides; Duodenum; Ileum; Intestinal Absorption; Intestinal Mucosa; Jejunum; Mice; Mice, Knockout; Models, Biological; Peptide Transporter 1; Perfusion; Permeability; Reproducibility of Results; Symporters; Valacyclovir; Valine

2013