Page last updated: 2024-08-26

glycylsarcosine and cephalexin

glycylsarcosine has been researched along with cephalexin in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's9 (50.00)18.2507
2000's6 (33.33)29.6817
2010's3 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brandsch, M; Ganapathy, ME; Ganapathy, V; Leibach, FH; Prasad, PD1
Fei, YJ; Ganapathy, V; Han, H; Hediger, MA; Leibach, FH; Liang, R; Prasad, PD; Ramamoorthy, S; Yang-Feng, TL1
Amidon, GL; Covitz, KM; Sadée, W1
Inui, K; Mukai, M; Saito, H; Terada, T1
Amidon, GL; Han, HK; Hsu, CP; Oh, DM; Rhie, JK; Saito, G; Stewart, BH1
Balimane, PV; Guo, A; Hu, P; Leibach, FH; Sinko, PJ1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Brown, CD; Hirst, BH; Simmons, NL; Thwaites, DT1
Brandsch, C; Brandsch, M; Chew, CS; Ganapathy, ME; Ganapathy, V; Leibach, FH1
Grenacher, B; Scharrer, E; Wolffram, S1
Amidon, GL; Chu, X; Fleisher, D; Komorowski, TE; Landowski, CP; Sun, D; Wallsten, R1
Benet, LZ; Pan, L; Putnam, WS; Takahashi, L; Tsutsui, K1
Endou, H; Kuroda, M; Kusuhara, H; Sugiyama, Y1
Aiba, T; Kawasaki, H; Komori, Y; Kurosaki, Y; Nakai, C; Sugiyama, R1
Bado, A; Buyse, M; Farinotti, R; Hindlet, P1
Brodin, B; Nielsen, CU; Søndergaard, HB1
Guo, X; Kaku, T; Liu, K; Liu, Q; Meng, Q; Sun, H; Wang, C1

Reviews

1 review(s) available for glycylsarcosine and cephalexin

ArticleYear
Membrane transporters in drug development.
    Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3

    Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs

2010

Other Studies

17 other study(ies) available for glycylsarcosine and cephalexin

ArticleYear
Differential recognition of beta -lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2.
    The Journal of biological chemistry, 1995, Oct-27, Volume: 270, Issue:43

    Topics: Animals; Anti-Bacterial Agents; Biological Transport; Blotting, Northern; Carrier Proteins; Cefadroxil; Cells, Cultured; Cephalexin; Cephalosporins; Cyclacillin; Dipeptides; Dose-Response Relationship, Drug; Humans; Intestine, Small; Kidney; Penicillins; Peptide Transporter 1; Polymerase Chain Reaction; Rats; Recombinant Proteins; RNA, Messenger; Symporters; Vaccinia virus

1995
Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization.
    The Journal of biological chemistry, 1995, Mar-24, Volume: 270, Issue:12

    Topics: Amino Acid Sequence; Animals; Base Sequence; Biological Transport; Carrier Proteins; Chromosome Mapping; Chromosomes, Human, Pair 13; Cloning, Molecular; DNA, Complementary; HeLa Cells; Humans; Intestines; Molecular Sequence Data; Peptide Transporter 1; RNA, Messenger; Symporters; Xenopus laevis

1995
Human dipeptide transporter, hPEPT1, stably transfected into Chinese hamster ovary cells.
    Pharmaceutical research, 1996, Volume: 13, Issue:11

    Topics: Ampicillin; Animals; Biological Transport; Carrier Proteins; Cephalexin; Cephalosporins; CHO Cells; Clone Cells; COS Cells; Cricetinae; DNA, Complementary; Dogs; HeLa Cells; Humans; Hydrogen-Ion Concentration; Oligopeptides; Penicillins; Peptide Transporter 1; Sensitivity and Specificity; Symporters; Transfection

1996
Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells.
    The American journal of physiology, 1997, Volume: 273, Issue:5

    Topics: Animals; Anti-Bacterial Agents; Biological Transport; Carrier Proteins; Ceftibuten; Cephalosporins; Cyclacillin; Dipeptides; Hydrogen-Ion Concentration; Kidney; Kinetics; LLC-PK1 Cells; Peptide Transporter 1; Rats; Recombinant Proteins; Structure-Activity Relationship; Symporters; Transfection

1997
CHO/hPEPT1 cells overexpressing the human peptide transporter (hPEPT1) as an alternative in vitro model for peptidomimetic drugs.
    Journal of pharmaceutical sciences, 1999, Volume: 88, Issue:3

    Topics: Animals; Biological Transport; Caco-2 Cells; Carrier Proteins; CHO Cells; Cricetinae; Dipeptides; Humans; Kinetics; Peptide Transporter 1; Reproducibility of Results; Symporters; Transfection

1999
Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell line.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:1

    Topics: Acyclovir; Animals; Anti-Bacterial Agents; Antiviral Agents; Biological Transport; Caco-2 Cells; Carrier Proteins; CHO Cells; Cricetinae; Dipeptides; Humans; Hydrogen-Ion Concentration; Kinetics; Lactams; Peptide Transporter 1; Rabbits; Rats; Symporters; Transfection; Valacyclovir; Valine

1999
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
H(+)-coupled dipeptide (glycylsarcosine) transport across apical and basal borders of human intestinal Caco-2 cell monolayers display distinctive characteristics.
    Biochimica et biophysica acta, 1993, Sep-19, Volume: 1151, Issue:2

    Topics: Biological Transport; Carbon Radioisotopes; Cell Compartmentation; Cell Line; Cell Membrane; Cell Membrane Permeability; Cephalexin; Cephalosporins; Dipeptides; Epithelium; Humans; Hydrogen-Ion Concentration; Intestinal Mucosa

1993
Influence of proton and essential histidyl residues on the transport kinetics of the H+/peptide cotransport systems in intestine (PEPT 1) and kidney (PEPT 2).
    Biochimica et biophysica acta, 1997, Mar-13, Volume: 1324, Issue:2

    Topics: Animals; Biological Transport; Caco-2 Cells; Carrier Proteins; Cell Line; Cephalexin; Diethyl Pyrocarbonate; Dipeptides; Dose-Response Relationship, Drug; Histidine; Humans; Kidney Tubules, Proximal; Kinetics; Peptide Transporter 1; Protons; Rats; Symporters

1997
H(+)-coupled uphill transport of the dipeptide glycylsarcosine by bovine intestinal brush-border membrane vesicles.
    Journal of dairy science, 1998, Volume: 81, Issue:10

    Topics: Animals; Biological Transport; Cattle; Cephalexin; Cephalosporins; Dipeptides; Female; Ileum; Intestines; Jejunum; Kinetics; Membrane Potentials; Microvilli; Protons

1998
Drug inhibition of Gly-Sar uptake and hPepT1 localization using hPepT1-GFP fusion protein.
    AAPS pharmSci, 2001, Volume: 3, Issue:1

    Topics: Acyclovir; Blotting, Western; Caco-2 Cells; Carrier Proteins; Cell Membrane; Cephalexin; Depression, Chemical; Dipeptides; Green Fluorescent Proteins; HeLa Cells; Humans; Luminescent Proteins; Microscopy, Confocal; Peptide Transporter 1; Recombinant Fusion Proteins; Subcellular Fractions; Symporters; Transfection; Valacyclovir; Valine

2001
Comparison of bidirectional cephalexin transport across MDCK and caco-2 cell monolayers: interactions with peptide transporters.
    Pharmaceutical research, 2002, Volume: 19, Issue:1

    Topics: Animals; Biological Transport; Caco-2 Cells; Cell Line; Cell Membrane Permeability; Cephalexin; Dipeptides; Dogs; Humans; Hydrogen-Ion Concentration; Kidney; Models, Biological; p-Aminohippuric Acid; Tetraethylammonium; Time Factors

2002
Rapid elimination of cefaclor from the cerebrospinal fluid is mediated by a benzylpenicillin-sensitive mechanism distinct from organic anion transporter 3.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:2

    Topics: Animals; Cefaclor; Cephalexin; Cephalosporins; Choroid Plexus; Chromatography, High Pressure Liquid; Depression, Chemical; Dipeptides; DNA, Complementary; Injections, Intraventricular; LLC-PK1 Cells; Male; Organic Anion Transporters, Sodium-Independent; Penicillin G; Penicillins; Rats; Rats, Sprague-Dawley; Spectrum Analysis; Swine; Symporters; Transfection

2005
Effects of capsaicin on intestinal cephalexin absorption in rats.
    Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:3

    Topics: Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Capsaicin; Cell Membrane Permeability; Cephalexin; Dipeptides; Dose-Response Relationship, Drug; Ileum; Intestinal Absorption; Jejunum; Male; Metabolic Clearance Rate; Peptide Transporter 1; Perfusion; Rats; Rats, Wistar; Ruthenium Red; Symporters; TRPV Cation Channels

2007
Long-term effect of leptin on H+-coupled peptide cotransporter 1 activity and expression in vivo: evidence in leptin-deficient mice.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 323, Issue:1

    Topics: Animals; Biological Transport; Blotting, Western; Caco-2 Cells; Cephalexin; Chromatography, High Pressure Liquid; Dipeptides; Humans; Jejunum; Leptin; Male; Mice; Mice, Inbred C57BL; Peptide Transporter 1; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Symporters; Time Factors

2007
hPEPT1 is responsible for uptake and transport of Gly-Sar in the human bronchial airway epithelial cell-line Calu-3.
    Pflugers Archiv : European journal of physiology, 2008, Volume: 456, Issue:3

    Topics: Aminolevulinic Acid; Blotting, Western; Bronchi; Captopril; Cell Line; Cell Membrane; Cephalexin; Dipeptides; Epithelial Cells; Haplotypes; Humans; Hydrogen-Ion Concentration; Immunohistochemistry; Kinetics; Microscopy, Confocal; Peptide Transporter 1; Respiratory Mucosa; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Symporters; Transcription, Genetic; Transfection

2008
Construction, identification and application of HeLa cells stably transfected with human PEPT1 and PEPT2.
    Peptides, 2012, Volume: 34, Issue:2

    Topics: Biological Transport; Cell Engineering; Cephalexin; Chromatography, Liquid; Dipeptides; Drug Interactions; Escherichia coli; Gene Expression; HeLa Cells; Humans; Hydrogen-Ion Concentration; Kinetics; Liposomes; Lisinopril; Peptide Transporter 1; Peptides, Cyclic; Plasmids; Symporters; Tandem Mass Spectrometry; Transfection

2012