Page last updated: 2024-08-26

glycylsarcosine and acyclovir

glycylsarcosine has been researched along with acyclovir in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (33.33)18.2507
2000's5 (41.67)29.6817
2010's3 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Artursson, P; Bergström, CA; Matsson, P; Nagahara, N; Norinder, U; Tavelin, S1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K1
Ganapathy, ME; Ganapathy, V; Huang, W; Leibach, FH; Wang, H1
Amidon, GL; Han, HK; Oh, DM1
Balimane, PV; Guo, A; Hu, P; Leibach, FH; Sinko, PJ1
Hashimoto, Y; Inui, KI; Saito, H; Sawada, K; Terada, T1
Inui, K; Irie, M; Saito, H; Sawada, K; Terada, T1
Amidon, GL; Chu, X; Fleisher, D; Komorowski, TE; Landowski, CP; Sun, D; Wallsten, R1
Anand, BS; Mitra, AK; Patel, J1
Atluri, H; Dias, C; Mitra, A; Nashed, Y1
Smith, DE; Yang, B1

Reviews

1 review(s) available for glycylsarcosine and acyclovir

ArticleYear
Membrane transporters in drug development.
    Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3

    Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs

2010

Other Studies

11 other study(ies) available for glycylsarcosine and acyclovir

ArticleYear
Exploring the role of different drug transport routes in permeability screening.
    Journal of medicinal chemistry, 2005, Jan-27, Volume: 48, Issue:2

    Topics: Administration, Oral; Biological Transport; Caco-2 Cells; Cell Line; Humans; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Membranes, Artificial; Models, Biological; Molecular Conformation; Monte Carlo Method; Permeability; Pharmaceutical Preparations; Pharmacokinetics

2005
QSAR-based permeability model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8

    Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship

2011
Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2.
    Biochemical and biophysical research communications, 1998, May-19, Volume: 246, Issue:2

    Topics: Acyclovir; Animals; Antiviral Agents; Biological Transport, Active; Caco-2 Cells; Carrier Proteins; Cell Line; Dipeptides; HeLa Cells; Humans; Intestinal Mucosa; Kidney; Kinetics; Peptide Transporter 1; Prodrugs; Rats; Recombinant Proteins; Symporters; Valacyclovir; Valine

1998
Cellular uptake mechanism of amino acid ester prodrugs in Caco-2/hPEPT1 cells overexpressing a human peptide transporter.
    Pharmaceutical research, 1998, Volume: 15, Issue:9

    Topics: Acyclovir; Amino Acids; Anti-HIV Agents; Antiviral Agents; Binding, Competitive; Biological Transport; Caco-2 Cells; Cadherins; Carrier Proteins; Dipeptides; Esters; Humans; Hydrolysis; Kinetics; Membrane Transport Proteins; Prodrugs; Valacyclovir; Valine; Zidovudine

1998
Interactions of a nonpeptidic drug, valacyclovir, with the human intestinal peptide transporter (hPEPT1) expressed in a mammalian cell line.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:1

    Topics: Acyclovir; Animals; Anti-Bacterial Agents; Antiviral Agents; Biological Transport; Caco-2 Cells; Carrier Proteins; CHO Cells; Cricetinae; Dipeptides; Humans; Hydrogen-Ion Concentration; Kinetics; Lactams; Peptide Transporter 1; Rabbits; Rats; Symporters; Transfection; Valacyclovir; Valine

1999
Recognition of L-amino acid ester compounds by rat peptide transporters PEPT1 and PEPT2.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 291, Issue:2

    Topics: Acyclovir; Amino Acids; Animals; Carrier Proteins; Dipeptides; Dose-Response Relationship, Drug; LLC-PK1 Cells; Prodrugs; Rats; Swine; Transfection; Valacyclovir; Valine

1999
Recognition and transport characteristics of nonpeptidic compounds by basolateral peptide transporter in Caco-2 cells.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 298, Issue:2

    Topics: Acyclovir; Aminolevulinic Acid; Antiviral Agents; ATP-Binding Cassette Transporters; Caco-2 Cells; Carrier Proteins; Diethyl Pyrocarbonate; Dipeptides; Humans; Peptide Transporter 1; Photosensitizing Agents; Symporters; Valacyclovir; Valine

2001
Drug inhibition of Gly-Sar uptake and hPepT1 localization using hPepT1-GFP fusion protein.
    AAPS pharmSci, 2001, Volume: 3, Issue:1

    Topics: Acyclovir; Blotting, Western; Caco-2 Cells; Carrier Proteins; Cell Membrane; Cephalexin; Depression, Chemical; Dipeptides; Green Fluorescent Proteins; HeLa Cells; Humans; Luminescent Proteins; Microscopy, Confocal; Peptide Transporter 1; Recombinant Fusion Proteins; Subcellular Fractions; Symporters; Transfection; Valacyclovir; Valine

2001
Interactions of the dipeptide ester prodrugs of acyclovir with the intestinal oligopeptide transporter: competitive inhibition of glycylsarcosine transport in human intestinal cell line-Caco-2.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 304, Issue:2

    Topics: Acyclovir; Binding, Competitive; Caco-2 Cells; Carrier Proteins; Dipeptides; Drug Interactions; Esters; Humans; Intestinal Mucosa; Intestines; Oligopeptides; Peptide Transporter 1; Prodrugs; Symporters

2003
Ocular penetration of acyclovir and its peptide prodrugs valacyclovir and val-valacyclovir following systemic administration in rabbits: An evaluation using ocular microdialysis and LC-MS.
    Current eye research, 2002, Volume: 25, Issue:4

    Topics: Acyclovir; Animals; Antiviral Agents; Aqueous Humor; Area Under Curve; Chromatography, Liquid; Dipeptides; Evaluation Studies as Topic; Eye; Male; Mass Spectrometry; Microdialysis; Models, Animal; Ocular Physiological Phenomena; Prodrugs; Rabbits; Time Factors; Tritium; Valacyclovir; Valine; Vitreous Body

2002
Significance of peptide transporter 1 in the intestinal permeability of valacyclovir in wild-type and PepT1 knockout mice.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:3

    Topics: Acyclovir; Administration, Oral; Animals; Antiviral Agents; Binding, Competitive; Biotransformation; Cefadroxil; Chromatography, High Pressure Liquid; Colon; Dipeptides; Duodenum; Ileum; Intestinal Absorption; Intestinal Mucosa; Jejunum; Mice; Mice, Knockout; Models, Biological; Peptide Transporter 1; Perfusion; Permeability; Reproducibility of Results; Symporters; Valacyclovir; Valine

2013