glycyl-prolyl-hydroxyproline has been researched along with prolyl-4-hydroxyproline* in 1 studies
1 other study(ies) available for glycyl-prolyl-hydroxyproline and prolyl-4-hydroxyproline
| Article | Year |
|---|---|
Oral Ingestion of Collagen Hydrolysate Leads to the Transportation of Highly Concentrated Gly-Pro-Hyp and Its Hydrolyzed Form of Pro-Hyp into the Bloodstream and Skin.
Collagen hydrolysate is a well-known dietary supplement for the treatment of skin aging; however, its mode of action remains unknown. Previous studies have shown that the oral ingestion of collagen hydrolysate leads to elevated levels of collagen-derived peptides in the blood, but whether these peptides reach the skin remains unclear. Here, we analyzed the plasma concentration of collagen-derived peptides after ingestion of high tripeptide containing collagen hydrolysate in humans. We identified 17 types of collagen-derived peptides transiently, with a particular enrichment in Gly-Pro-Hyp. This was also observed using an in vivo mouse model in the plasma and skin, albeit with a higher enrichment of Pro-Hyp in the skin. Interestingly, this Pro-Hyp enrichment in the skin was derived from Gly-Pro-Hyp hydrolysis, as the administration of pure Gly-Pro-Hyp peptide led to similar results. Therefore, we propose that functional peptides can be transferred to the skin by dietary supplements of collagen. Topics: Adult; Animals; Collagen; Dipeptides; Eating; Female; Humans; Hydrolysis; Male; Mice; Mice, Inbred BALB C; Oligopeptides; Protein Hydrolysates; Skin; Young Adult | 2017 |