glycyl-prolyl-glutamic-acid has been researched along with cyclo(prolylglycyl)* in 1 studies
1 other study(ies) available for glycyl-prolyl-glutamic-acid and cyclo(prolylglycyl)
| Article | Year |
|---|---|
Improvement in inflammation is associated with the protective effect of Gly-Pro-Glu and cycloprolylglycine against Aβ-induced depletion of the hippocampal somatostatinergic system.
Glycine-proline-glutamate (GPE) is a cleaved tripeptide of IGF-I that can be processed to cycloprolylglycine (cPG) in the brain. IGF-I protects the hippocampal somatostatinergic system from β-amyloid (Aβ) insult and although neither IGF-I-derived peptides bind to IGF-I receptors, they exert protective actions in several neurological disorders. As their effects on the hippocampal somatostatinergic system remain unknown, the objective of this study was to evaluate if cPG and/or GPE prevent the deleterious effects of Aβ Topics: Amyloid beta-Peptides; Animals; Cell Death; Female; Hippocampus; Inflammation; Neurons; Neuroprotective Agents; Oligopeptides; Peptide Fragments; Peptides, Cyclic; Phosphorylation; Rats; Rats, Wistar; Receptors, Somatostatin; Signal Transduction; Somatostatin | 2019 |