Page last updated: 2024-09-03

glycolithocholic acid and lithocholic acid

glycolithocholic acid has been researched along with lithocholic acid in 27 studies

Compound Research Comparison

Studies
(glycolithocholic acid)
Trials
(glycolithocholic acid)
Recent Studies (post-2010)
(glycolithocholic acid)
Studies
(lithocholic acid)
Trials
(lithocholic acid)
Recent Studies (post-2010) (lithocholic acid)
32041,11124280

Protein Interaction Comparison

ProteinTaxonomyglycolithocholic acid (IC50)lithocholic acid (IC50)
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1Homo sapiens (human)4.823
60 kDa heat shock protein, mitochondrialHomo sapiens (human)10
Tyrosine-protein phosphatase non-receptor type 2Homo sapiens (human)6.12
Tyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)2.71
10 kDa heat shock protein, mitochondrialHomo sapiens (human)10
Bile acid receptorHomo sapiens (human)0.0183
large T antigenBetapolyomavirus macacae26.1

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-199012 (44.44)18.7374
1990's7 (25.93)18.2507
2000's5 (18.52)29.6817
2010's3 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hagenbuch, B; Meier, PJ1
Hummel-Eisenbeiss, J; Jedlitschky, G; Keppler, D; Nies, AT; Rius, M1
Auwerx, J; Gioiello, A; Hofmann, AF; Macchiarulo, A; Pellicciari, R; Saladin, R; Sato, H; Schoonjans, K; Thomas, C; Une, M1
Barocelli, E; Giorgio, C; Hassan-Mohamed, I; Incerti, M; Lodola, A; Mor, M; Noberini, R; Pala, D; Pasquale, EB; Piersanti, S; Rivara, S; Russo, S; Tognolini, M; Vicini, P1
Arnold, LA; Bikle, DD; Bogart, JW; Cook, JM; Preston, JV; Sanchez, LM; Silvaggi, NR; Teske, KA; Yu, OB1
Dravis, D; Henkels, K; Singer, SS; Trulzsch, DV1
Hardonk, MJ; Kuipers, F; van der Meer, R; Vonk, RJ1
East, PB; Eckers, C; Haskins, NJ1
Belli, DC; Fournier, LA; Giguère, R; Roy, CC; Tuchweber, B; Yousef, IM1
Kuipers, F; van der Meer, R; Vonk, RJ1
Enserink, M; Fevery, J; Hardonk, MJ; Havinga, R; Kuipers, F; van der Steen, AB; Vonk, RJ1
Barnes, S; Crenshaw, J; King, RJ; Taylor, KB; Waldrop, R1
Derksen, JP; Gerding, A; Kuipers, F; Scherphof, GL; Vonk, RJ1
Havinga, R; Heslinga, H; Kuipers, F; Vonk, RJ1
Killenberg, PG; Kirkpatrick, RB; Wildermann, NM1
Chen, LJ; Segel, IH1
Akashi, Y; Miyazaki, H; Nakayama, F; Yanagisawa, J1
Lööf, L; Nyberg, A1
Chen, LJ2
Batta, AK; Salen, G; Shefer, S1
Burgoyne, RD; Chipman, JK; Coleman, R; Matthews, GM; Mills, CO; Wilton, JC1
Ishida, T; Kaneko, JJ; Tomoda, I; Washizu, M; Washizu, T1
Bogle, MA; Carey, MC; Donovan, JM; Leonard, MR1
Chen, Y; Cheng, K; Kennedy, RH; Khurana, S; Raufman, JP; Zimniak, P1
Chen, Y; Cheng, K; Compadre, C; Compadre, L; Raufman, JP; Zimniak, P1
Bansal, S; Lau, AJ1

Other Studies

27 other study(ies) available for glycolithocholic acid and lithocholic acid

ArticleYear
Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter.
    The Journal of clinical investigation, 1994, Volume: 93, Issue:3

    Topics: Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Chromosome Mapping; Cloning, Molecular; Humans; Liver; Molecular Sequence Data; Organic Anion Transporters, Sodium-Dependent; Symporters; Xenopus laevis

1994
Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane.
    Hepatology (Baltimore, Md.), 2003, Volume: 38, Issue:2

    Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Antibodies; Carcinoma, Hepatocellular; Cell Polarity; Cholagogues and Choleretics; Cricetinae; Fibroblasts; Gene Expression; Glutathione; Hepatocytes; Humans; Liver Neoplasms; Male; Mice; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Rats; Taurocholic Acid; Transfection; Transport Vesicles; Tritium

2003
Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies.
    Journal of medicinal chemistry, 2008, Mar-27, Volume: 51, Issue:6

    Topics: Animals; Bile Acids and Salts; CHO Cells; Cricetinae; Cricetulus; Drug Design; Drug Evaluation, Preclinical; Hormones; Humans; Ligands; Models, Molecular; Molecular Conformation; Receptors, G-Protein-Coupled; Stereoisomerism; Structure-Activity Relationship

2008
Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor.
    Journal of medicinal chemistry, 2013, Apr-11, Volume: 56, Issue:7

    Topics: Adenocarcinoma; Amino Acids; Enzyme-Linked Immunosorbent Assay; Humans; Lithocholic Acid; Male; Models, Molecular; Phosphorylation; Prostatic Neoplasms; Receptor, EphA2

2013
Synthesis and evaluation of vitamin D receptor-mediated activities of cholesterol and vitamin D metabolites.
    European journal of medicinal chemistry, 2016, Feb-15, Volume: 109

    Topics: Calcitriol; Cell Line, Tumor; Cholesterol; Glucuronates; Humans; Lithocholic Acid; Male; Prostatic Neoplasms; Receptors, Calcitriol; Transcription, Genetic; Vitamin D; Vitamin D3 24-Hydroxylase

2016
Fatty acid binding protein inhibits glycolithocholate sulfation.
    Biochemistry international, 1992, Volume: 27, Issue:3

    Topics: Animals; Bile Acids and Salts; Carrier Proteins; Cytosol; Depression, Chemical; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Female; Inactivation, Metabolic; Lithocholic Acid; Male; Neoplasm Proteins; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; Rose Bengal; Sex Characteristics; Substrate Specificity; Sulfotransferases

1992
Bile secretion of sulfated glycolithocholic acid is required for its cholestatic action in rats.
    The American journal of physiology, 1992, Volume: 262, Issue:2 Pt 1

    Topics: Animals; Bile; Calcium; Cholestasis; Cytoplasm; Glycocholic Acid; Lithocholic Acid; Liver; Male; Rats; Rats, Inbred Strains; Rats, Mutant Strains; Vacuoles

1992
The use of negative ion thermospray liquid chromatography/tandem mass spectrometry for the determination of bile acids and their glycine conjugates.
    Biological mass spectrometry, 1991, Volume: 20, Issue:11

    Topics: Chenodeoxycholic Acid; Cholic Acid; Cholic Acids; Chromatography, Liquid; Deoxycholic Acid; Glycochenodeoxycholic Acid; Glycocholic Acid; Glycodeoxycholic Acid; Lithocholic Acid; Mass Spectrometry

1991
The effect of taurine on the cholestatic potential of sulfated lithocholate and its conjugates.
    Liver, 1991, Volume: 11, Issue:3

    Topics: Animals; Bile; Bile Acids and Salts; Cholestasis; Guinea Pigs; Lithocholic Acid; Liver; Male; Taurine; Taurolithocholic Acid

1991
Cholestasis and the interactions of sulfated glyco- and taurolithocholate with calcium.
    The American journal of physiology, 1988, Volume: 254, Issue:5 Pt 1

    Topics: Animals; Bile Acids and Salts; Calcium; Calcium Phosphates; Cholestasis; Hydrogen-Ion Concentration; Lithocholic Acid; Male; Micelles; Rats; Rats, Inbred Strains; Splanchnic Circulation; Taurolithocholic Acid

1988
Separate transport systems for biliary secretion of sulfated and unsulfated bile acids in the rat.
    The Journal of clinical investigation, 1988, Volume: 81, Issue:5

    Topics: Animals; Bile; Bile Acids and Salts; Bilirubin; Biological Transport; Histocytochemistry; Lithocholic Acid; Liver; Liver Function Tests; Male; Microscopy, Electron; Rats; Rats, Inbred Strains; Sulfobromophthalein; Taurochenodeoxycholic Acid; Taurocholic Acid; Taurolithocholic Acid

1988
Evidence for an ordered reaction mechanism for bile salt: 3'phosphoadenosine-5'-phosphosulfate: sulfotransferase from rhesus monkey liver that catalyzes the sulfation of the hepatotoxin glycolithocholate.
    Journal of lipid research, 1986, Volume: 27, Issue:11

    Topics: Animals; Kinetics; Lithocholic Acid; Liver; Macaca mulatta; Magnesium; Molecular Weight; Substrate Specificity; Sulfotransferases; Sulfurtransferases

1986
Biliary lipid secretion in the rat. The uncoupling of biliary cholesterol and phospholipid secretion from bile acid secretion by sulfated glycolithocholic acid.
    Biochimica et biophysica acta, 1987, Nov-21, Volume: 922, Issue:2

    Topics: Animals; Bile; Bile Acids and Salts; Cholesterol; Glycocholic Acid; Kinetics; Liposomes; Lithocholic Acid; Male; Phospholipids; Rats; Rats, Inbred Strains

1987
Intestinal absorption of lithocholic acid sulfates in the rat: inhibitory effects of calcium.
    The American journal of physiology, 1986, Volume: 251, Issue:2 Pt 1

    Topics: Animals; Bile; Bile Acids and Salts; Calcium; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Enterohepatic Circulation; Glycocholic Acid; Intestinal Absorption; Lithocholic Acid; Male; Rats; Rats, Inbred Strains; Taurocholic Acid; Taurolithocholic Acid

1986
Androgens and estrogens affect hepatic bile acid sulfotransferase in male rats.
    The American journal of physiology, 1985, Volume: 248, Issue:6 Pt 1

    Topics: Androgens; Animals; Castration; Dihydrotestosterone; Estradiol; Estrogen Antagonists; Estrogens; Ethinyl Estradiol; Hydrocortisone; Lithocholic Acid; Liver; Male; Norethindrone; Prolactin; Rats; Rats, Inbred Strains; Sulfotransferases; Sulfurtransferases; Testis; Time Factors

1985
Purification and characterization of bile salt sulfotransferase from human liver.
    Archives of biochemistry and biophysics, 1985, Volume: 241, Issue:2

    Topics: Adenosine Diphosphate; Humans; Kinetics; Lithocholic Acid; Liver; Molecular Weight; Phosphoadenosine Phosphosulfate; Substrate Specificity; Sulfotransferases; Sulfurtransferases

1985
Critical evaluation of the existence of so-called tissue-bound lithocholate in human liver tissue by selected ion monitoring.
    Journal of lipid research, 1984, Volume: 25, Issue:11

    Topics: Adult; Aged; Carbon Radioisotopes; Cholelithiasis; Female; Humans; Hydrolysis; Lithocholic Acid; Liver; Liver Cirrhosis; Male; Mass Spectrometry; Middle Aged; Radioisotope Dilution Technique

1984
Bile salt sulphation in man. Liver bile salt sulphotransferase activity in patients with primary biliary cirrhosis.
    Upsala journal of medical sciences, 1983, Volume: 88, Issue:1

    Topics: Adult; Aged; Alkaline Phosphatase; Bile Acids and Salts; Bilirubin; Female; Humans; Lithocholic Acid; Liver; Liver Cirrhosis, Alcoholic; Liver Cirrhosis, Biliary; Male; Middle Aged; Sulfotransferases; Sulfurtransferases

1983
A simple method for the assay of bile salt sulfotransferase using glycolithocholate coupled to Sepharose.
    Analytical biochemistry, 1980, Volume: 105, Issue:1

    Topics: Animals; Bile Acids and Salts; Female; Lithocholic Acid; Liver; Rats; Sepharose; Sulfotransferases; Sulfurtransferases

1980
Bile salt sulfotransferase.
    Methods in enzymology, 1981, Volume: 77

    Topics: Animals; Cations, Divalent; Cricetinae; Enzyme Activation; Guinea Pigs; Humans; Kidney; Lithocholic Acid; Liver; Methods; Molecular Weight; Phosphoadenosine Phosphosulfate; Rabbits; Rats; Scintillation Counting; Substrate Specificity; Sulfotransferases; Sulfurtransferases; Taurolithocholic Acid

1981
Thin-layer chromatographic separation of conjugates of ursodeoxycholic acid from those of litho-, chenodeoxy-, deoxy-, and cholic acids.
    Journal of lipid research, 1981, Volume: 22, Issue:4

    Topics: Chenodeoxycholic Acid; Chromatography, Thin Layer; Deoxycholic Acid; Glycine; Glycochenodeoxycholic Acid; Glycocholic Acid; Glycodeoxycholic Acid; Lithocholic Acid; Taurochenodeoxycholic Acid; Taurocholic Acid; Taurodeoxycholic Acid; Taurolithocholic Acid; Ursodeoxycholic Acid

1981
Fluorescent choleretic and cholestatic bile salts take different paths across the hepatocyte: transcytosis of glycolithocholate leads to an extensive redistribution of annexin II.
    The Journal of cell biology, 1994, Volume: 127, Issue:2

    Topics: Actins; Animals; Annexin A2; Bile Acids and Salts; Biological Transport; Brefeldin A; Cholic Acids; Colchicine; Cyclopentanes; Fluoresceins; Glycocholic Acid; Lithocholic Acid; Liver; Male; Microtubules; Rats; Rats, Wistar; Vacuoles

1994
Changes in bile acid composition of serum and gallbladder bile in bile duct ligated dogs.
    The Journal of veterinary medical science, 1994, Volume: 56, Issue:2

    Topics: Animals; Bile Acids and Salts; Bile Ducts; Chenodeoxycholic Acid; Cholestasis; Cholic Acid; Cholic Acids; Dogs; Gallbladder; Lithocholic Acid; Taurochenodeoxycholic Acid; Taurocholic Acid; Taurodeoxycholic Acid; Time Factors

1994
Spread monomolecular films of monohydroxy bile acids and their salts: influence of hydroxyl position, bulk pH, and association with phosphatidylcholine.
    Biochemistry, 2000, Dec-26, Volume: 39, Issue:51

    Topics: Hydrogen-Ion Concentration; Isomerism; Lithocholic Acid; Micelles; Models, Molecular; Phosphatidylcholines; Phospholipids; Potentiometry; Pressure; Solutions; Surface Properties

2000
Lithocholylcholine, a bile acid/acetylcholine hybrid, is a muscarinic receptor antagonist.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:1

    Topics: Acetylcholine; Acetylcholinesterase; Animals; Aorta, Thoracic; Atropine; Carbachol; CHO Cells; Cricetinae; In Vitro Techniques; Inositol Phosphates; Kinetics; Lithocholic Acid; Male; Muscarinic Antagonists; Muscle, Smooth; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Recombinant Proteins; Taurolithocholic Acid

2002
Selective interaction of bile acids with muscarinic receptors: a case of molecular mimicry.
    European journal of pharmacology, 2002, Dec-20, Volume: 457, Issue:2-3

    Topics: Acetylcholine; Animals; Bile Acids and Salts; CHO Cells; Cloning, Molecular; Cricetinae; Humans; Inositol Phosphates; Lithocholic Acid; Mitogen-Activated Protein Kinases; Models, Molecular; Molecular Mimicry; Muscarinic Antagonists; N-Methylscopolamine; Phosphorylation; Radioligand Assay; Receptor, Muscarinic M3; Receptors, Muscarinic; Signal Transduction; Taurolithocholic Acid

2002
Inhibition of Human Sulfotransferase 2A1-Catalyzed Sulfonation of Lithocholic Acid, Glycolithocholic Acid, and Taurolithocholic Acid by Selective Estrogen Receptor Modulators and Various Analogs and Metabolites.
    The Journal of pharmacology and experimental therapeutics, 2019, Volume: 369, Issue:3

    Topics: Biocatalysis; Cytosol; Hep G2 Cells; Humans; Kinetics; Lithocholic Acid; Liver; Oxidation-Reduction; Selective Estrogen Receptor Modulators; Sulfonic Acids; Sulfotransferases; Taurolithocholic Acid

2019