glycodeoxycholic-acid and calcium-phosphate--monobasic--anhydrous

It is demonstrated that bile acids bind to insoluble calcium phosphate at pH values beyond 5.5. Significant binding occurs with glycine-conjugated dihydroxy bile acids. Results indicate that these bile acids are bound in a micellar mode. Taurine conjugation almost completely inhibits the binding of these bile acids to insoluble calcium phosphate. Since glycine-conjugated dihydroxy bile acids are predominant in the rabbit, but not in the rat, our results suggest an explanation for the intriguing species-dependence of casein-induced hypercholesterolaemia, which is high in the rabbit but absent in the rat.

Topics: Bile Acids and Salts; Calcium Phosphates; Glycine; Glycodeoxycholic Acid; Hydrogen-Ion Concentration; Taurine