glycitein and tectorigenin

glycitein has been researched along with tectorigenin* in 2 studies

Other Studies

2 other study(ies) available for glycitein and tectorigenin

Article	Year
Antioxidant mechanism of isoflavone metabolites in hydrogen peroxide-stimulated rat primary astrocytes: critical role of hemeoxygenase-1 and NQO1 expression. Journal of neurochemistry, 2011, Volume: 119, Issue:5 The brain is highly vulnerable to oxidative stress, thus controlling oxidative stress is considered to be an important therapeutic target for neurodegenerative diseases. In this study, we found that two isoflavone metabolites (tectorigenin and glycitein) inhibited hydrogen peroxide-induced reactive oxygen species (ROS) generation and subsequent cell death in rat primary astrocytes. The isoflavone metabolites increased the expression of phase II antioxidant enzymes, such as hemeoxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1), and pre-treatment of cells with their specific inhibitors or small interfering RNA (siRNA) reversed the antioxidant and cytoprotective effects of isoflavones. The results suggest that the antioxidant/cytoprotective effects of isoflavone metabolites are at least because of increased HO-1 and NQO1 expression. Further mechanistic studies revealed that isoflavones increase the binding of transcription factors [nuclear factor-E2-related factor 2 (Nrf2) and c-Jun] to the antioxidant response element (ARE) on HO-1 and NQO1 promoters. Down-regulation of Nrf2 and/or c-Jun using dominant-negative mutants (DNMs) or siRNA diminished the expression of HO-1 and NQO1, suggesting that Nrf2 and c-Jun are key transcription factors modulating HO-1/NQO1 expression. Moreover, PI3 kinase and mitogen-activated protein kinase (MAPK) signaling pathways were shown to be involved in HO-1 and/or NQO1 expression by isoflavones. Our data collectively suggest that HO-1 and NQO1 play a critical role in antioxidant effects of isoflavone metabolites in rat brain astrocytes. Topics: Animals; Antioxidants; Astrocytes; Cell Line, Tumor; Heme Oxygenase-1; Hydrogen Peroxide; Isoflavones; NAD(P)H Dehydrogenase (Quinone); Oxidants; Rats	2011
[Studies on chemical constituents of Maackia amurensis Rupr. et. Maxim]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2001, Volume: 26, Issue:6 To study the chemical constituents of EtOH extract from heartwood of Maackia amurensis.. Silica gel column chromatography and Sephadex LH-20 were employed to separate, and the compounds obtainedere elucidated by means of UV, IR, MS, 1H NMR, 13C NMR.. 4', 8-dihydroxyl-7-methoxylisoflavone (I), tectorigenin(II), glycitein(III) and resveratrol (IV) were isolated and identified.. Among them, Compound I was a new isoflavone and compound III was obtained from M. amurensis for the first time. Topics: Isoflavones; Maackia; Plants, Medicinal; Resveratrol; Stilbenes; Trees	2001

Article

Year

Antioxidant mechanism of isoflavone metabolites in hydrogen peroxide-stimulated rat primary astrocytes: critical role of hemeoxygenase-1 and NQO1 expression.

Journal of neurochemistry, 2011, Volume: 119, Issue:5

The brain is highly vulnerable to oxidative stress, thus controlling oxidative stress is considered to be an important therapeutic target for neurodegenerative diseases. In this study, we found that two isoflavone metabolites (tectorigenin and glycitein) inhibited hydrogen peroxide-induced reactive oxygen species (ROS) generation and subsequent cell death in rat primary astrocytes. The isoflavone metabolites increased the expression of phase II antioxidant enzymes, such as hemeoxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1), and pre-treatment of cells with their specific inhibitors or small interfering RNA (siRNA) reversed the antioxidant and cytoprotective effects of isoflavones. The results suggest that the antioxidant/cytoprotective effects of isoflavone metabolites are at least because of increased HO-1 and NQO1 expression. Further mechanistic studies revealed that isoflavones increase the binding of transcription factors [nuclear factor-E2-related factor 2 (Nrf2) and c-Jun] to the antioxidant response element (ARE) on HO-1 and NQO1 promoters. Down-regulation of Nrf2 and/or c-Jun using dominant-negative mutants (DNMs) or siRNA diminished the expression of HO-1 and NQO1, suggesting that Nrf2 and c-Jun are key transcription factors modulating HO-1/NQO1 expression. Moreover, PI3 kinase and mitogen-activated protein kinase (MAPK) signaling pathways were shown to be involved in HO-1 and/or NQO1 expression by isoflavones. Our data collectively suggest that HO-1 and NQO1 play a critical role in antioxidant effects of isoflavone metabolites in rat brain astrocytes.

Topics: Animals; Antioxidants; Astrocytes; Cell Line, Tumor; Heme Oxygenase-1; Hydrogen Peroxide; Isoflavones; NAD(P)H Dehydrogenase (Quinone); Oxidants; Rats

2011

[Studies on chemical constituents of Maackia amurensis Rupr. et. Maxim].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2001, Volume: 26, Issue:6

To study the chemical constituents of EtOH extract from heartwood of Maackia amurensis.. Silica gel column chromatography and Sephadex LH-20 were employed to separate, and the compounds obtainedere elucidated by means of UV, IR, MS, 1H NMR, 13C NMR.. 4', 8-dihydroxyl-7-methoxylisoflavone (I), tectorigenin(II), glycitein(III) and resveratrol (IV) were isolated and identified.. Among them, Compound I was a new isoflavone and compound III was obtained from M. amurensis for the first time.

Topics: Isoflavones; Maackia; Plants, Medicinal; Resveratrol; Stilbenes; Trees

2001