glycinexylidide has been researched along with lidocaine in 59 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 36 (61.02) | 18.7374 |
| 1990's | 11 (18.64) | 18.2507 |
| 2000's | 6 (10.17) | 29.6817 |
| 2010's | 4 (6.78) | 24.3611 |
| 2020's | 2 (3.39) | 2.80 |
| Authors | Studies |
|---|---|
| Byrnes, EW; Feldman, HS; McMaster, PD; Takman, BH; Tenthorey, PA | 1 |
| Block, AJ; Byrnes, EW; McMaster, PD; Tenthorey, PA | 1 |
| Block, AJ; Byrnes, EW; McMaster, PD; Ronfeld, RA; Tenthorey, PA | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Atkinson, AJ; Collinsworth, KA; Harrison, DC; Perlroth, F; Strong, JM; Winkle, RA | 1 |
| Grant, AO; Starmer, CF; Wendt, DJ | 1 |
| Chen, Y; Potter, JM | 1 |
| Allam, M; du Souich, P; Hartemann, D; Saunier, C | 1 |
| Barlow, JC; Lener, ME; Sands, MF; Watson, WA; Wilton, JH | 1 |
| Coutts, RT; Gray, MR; Ke, J; Tam, YK; Wyse, DG | 1 |
| Bennett, PB; Hondeghem, LM; Woosley, RL | 1 |
| Yamane, J | 1 |
| Estes, NA; Garan, H; Greenblatt, DJ; Manolis, AS; Ruskin, JN | 1 |
| Hanawa, K; Hasegawa, Y; Kawamoto, T; Ohno, H; Saegusa, Y; Watanabe, M | 1 |
| Heinzow, BG; McLean, AJ; Somogyi, A | 1 |
| Clements, MJ; Endrenyi, L; Feuer, KF; Nelson, SD; Pang, KS; Terrell, JA | 1 |
| Cross, R; Foster, J; Patterson, JH; Powell, JR; Wargin, W | 1 |
| Hovi-Viander, M; Kanto, J; Laurikainen, E; Lindberg, R | 1 |
| Kuhnert, BR; Kuhnert, PM; Philipson, EH; Pimental, R; Syracuse, CD; Zuspan, KJ | 1 |
| Cusson, J; Lawand, S; Matthews, C; Nattel, S; Talajic, M | 1 |
| Benjamin, DM; Greenblatt, DJ; Harmatz, JS; Willis, CR; Zinny, MA | 1 |
| Echizen, H; Inoue, R; Ishizaki, T; Kushida, K; Suganuma, T; Tomono, Y | 1 |
| Adjepon-Yamoah, KK; Prescott, LF | 1 |
| Ishizaki, T; Kushida, K; Oka, K; Suganuma, T | 1 |
| Broughton, A; Grant, AO; Klinger, JK; Stambler, BS; Starmer, CF; Strauss, HC | 1 |
| Barchowsky, A; Klinger, JK; Luzzi, FA; Strauss, HC; Wenger, TL | 1 |
| Kanto, J; Laurikainen, E; Lindberg, R; Marttila, R | 1 |
| Baldwin, RP; Halbert, MK | 1 |
| Abernethy, DR; Benjamin, DM; Greenblatt, DJ; Willis, CR | 1 |
| Kuhnert, BR; Philipson, EH; Syracuse, CD | 1 |
| Drayer, DE; Lorenzo, B; Reidenberg, MM; Werns, S | 1 |
| Jones, DA; McBurney, A; Stanley, PJ; Tovey, C; Ward, JW | 1 |
| Barchowsky, A; Routledge, PA; Shand, DG; Stargel, WW | 1 |
| Davis, LE; Neff-Davis, CA; Wilcke, JC | 1 |
| Waller, ES | 1 |
| Fukuda, S; Takeshita, H; Toda, N | 1 |
| Chamelian, M; du Souich, P; Lécrivain, A; Robichaud, A | 1 |
| Ajiki, K; Inoue, H; Kuo, TT; Murakawa, Y; Nozaki, A; Oikawa, N; Sugimoto, T; Usui, M; Yamashita, T | 1 |
| O'Neal, CL; Poklis, A | 1 |
| du Souich, P; Lê, KT; Maurice, H | 1 |
| Walson, PD | 1 |
| Kakiuchi, Y; Kohda, Y; Miyabe, M; Momose, Y | 1 |
| Alexson, SE; Diczfalusy, M; Halldin, M; Swedmark, S | 1 |
| Fukuda, T; Homma, M; Kakiuchi, Y; Kohda, Y; Miyabe, M; Toyooka, H | 1 |
| CRONIN, L; MARSHALL, HW; NOLAN, AC; SUTTERER, WF; WOOD, EH | 1 |
| CRONIN, L; MARSHALL, HW; NOLAN, AC; WOOD, EH | 1 |
| LEVERETT, SD; MILLER, PB | 1 |
| VANPATTEN, RE | 1 |
| BANCHERO, N; CRONIN, L; NOLAND, AC; WOOD, EH | 1 |
| BANCHERO, N; CRONIN, L; NOLAN, AC; WOOD, EH | 1 |
| De Martin, S; Floreani, M; Orlando, R; Padrini, R; Palatini, P; Piccoli, P | 1 |
| Carrell, RW; Corral, J; Vicente, V | 1 |
| Bertoli, M; De Martin, S; Orlando, R; Palatini, P; Pegoraro, P | 1 |
| Brown, KA; de Solis, CN; Dickey, EJ; McKenzie, HC | 1 |
| Liang, MZ; Nan, F; Qin, YP; Xiang, J; Yu, Q; Zhang, C | 1 |
| Aragón, C; Bauer, I; Brandenburger, T; Eulenburg, V; Hermanns, H; Jadasz, J; Kremer, D; Küry, P; Schlösser, L; Werdehausen, R | 1 |
| Kushner, H; Martell, B; Mayer, P; Mize, A; Richardson, E | 1 |
| Christians, U; Crouch, CE; Fernandez-Bustamante, A; Hendrickse, A; Henthorn, TK; Kaizer, AM; Schniedewind, B; Wilkey, BJ | 1 |
| Arthur, RM; Blea, J; Katzman, S; Knych, HK; McKemie, DS | 1 |
5 trial(s) available for glycinexylidide and lidocaine
| Article | Year |
|---|---|
Effect of duration of lidocaine infusion and route of cimetidine administration on lidocaine pharmacokinetics.
Topics: Adult; Cimetidine; Dealkylation; Drug Interactions; Humans; Infusions, Intravenous; Kinetics; Lidocaine; Male | 1986 |
Cytochrome P450 1A2 is a major determinant of lidocaine metabolism in vivo: effects of liver function.
Topics: Anti-Arrhythmia Agents; Area Under Curve; Cross-Over Studies; Cytochrome P-450 CYP1A2 Inhibitors; Double-Blind Method; Fluvoxamine; Humans; Infusions, Intravenous; Lidocaine; Liver; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Selective Serotonin Reuptake Inhibitors; Severity of Illness Index | 2004 |
Differential effect of chronic renal failure on the pharmacokinetics of lidocaine in patients receiving and not receiving hemodialysis.
Topics: Area Under Curve; Biotransformation; Half-Life; Humans; Kidney Failure, Chronic; Lidocaine; Male; Metabolic Clearance Rate; Middle Aged; Renal Dialysis | 2006 |
Serum concentrations of lidocaine and its metabolites after prolonged infusion in healthy horses.
Topics: Anesthetics, Local; Animals; Chromatography, High Pressure Liquid; Cross-Over Studies; Female; Horses; Infusions, Parenteral; Lidocaine; Male; Safety; Time Factors | 2008 |
Pharmacokinetics of Lidocaine and Its Metabolites Following Vaginal Administration of Lidocaine Gel to Healthy Female Subjects.
Topics: Administration, Intravaginal; Adult; Anesthetics, Local; Dose-Response Relationship, Drug; Double-Blind Method; Female; Healthy Volunteers; Humans; Lidocaine; Young Adult | 2017 |
54 other study(ies) available for glycinexylidide and lidocaine
| Article | Year |
|---|---|
New antiarrhythmic agents. 2. Amide alkyl alpha-amino xylidides.
Topics: Aniline Compounds; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Chemical Phenomena; Chemistry; Chloroform; Coronary Vessels; Dogs; Mice; Structure-Activity Relationship; Xylenes | 1979 |
New antiarrhythmic agents. 5. alpha-Aminoaceto-2,6-xylidides with functionalized amide alkyl substituents.
Topics: Acetanilides; Anesthesia, Spinal; Animals; Anti-Arrhythmia Agents; Chemical Phenomena; Chemistry; Female; Lethal Dose 50; Mice; Sheep | 1981 |
New antiarrhythmic agents. 6. Quantitative structure-activity relationships of aminoxylidides.
Topics: Animals; Anti-Arrhythmia Agents; Central Nervous System; Chemical Phenomena; Chemistry; Female; Mice; Structure-Activity Relationship; Toluidines | 1981 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Pharmacokinetics and metabolism of lidocaine in patients with renal failure.
Topics: Computers; Ethylamines; Glycine; Half-Life; Humans; Kidney Failure, Chronic; Kinetics; Lidocaine; Xylenes | 1975 |
Kinetics of interaction of the lidocaine metabolite glycylxylidide with the cardiac sodium channel. Additive blockade with lidocaine.
Topics: Animals; Cells, Cultured; Drug Combinations; Heart; Heart Atria; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Lidocaine; Membrane Potentials; Models, Cardiovascular; Rabbits; Sodium Channels; Time Factors | 1992 |
Fluorescence polarization immunoassay and HPLC assays compared for measuring monoethylglycinexylidide in liver-transplant patients.
Topics: Bilirubin; Cholesterol; Chromatography, High Pressure Liquid; Fluorescence Polarization; Humans; Lidocaine; Liver Transplantation; Quality Control; Reference Values; Triglycerides | 1992 |
Effect of acute and chronic moderate hypoxia on the kinetics of lidocaine and its metabolites and on regional blood flow.
Topics: Animals; Dogs; Hypoxia; Kinetics; Lidocaine; Regional Blood Flow | 1992 |
Lidocaine absorption and metabolism after oropharyngeal application in young and young-elderly adults.
Topics: Absorption; Adult; Age Factors; Aged; Dosage Forms; Gels; Humans; Lidocaine; Middle Aged; Oropharynx; Sputum; Vocal Cords | 1991 |
Quantification of three lidocaine metabolites and their conjugates.
Topics: Acetaminophen; Chemistry Techniques, Analytical; Drug Stability; Glucuronates; Glucuronidase; Humans; Hydrolysis; Lidocaine; Sulfates | 1990 |
Competition between lidocaine and one of its metabolites, glycylxylidide, for cardiac sodium channels.
Topics: Animals; Binding, Competitive; Drug Interactions; Electrochemistry; Ion Channels; Lidocaine; Myocardium; Sodium; Time Factors | 1988 |
[Pharmacokinetics of lidocaine and its metabolites in dog. Comparison between normal and CCl4-induced hepatic lesion].
Topics: Animals; Chemical and Drug Induced Liver Injury; Dogs; Lidocaine | 1989 |
Therapeutic serum lidocaine and metabolite concentrations in patients undergoing electrophysiologic study after discontinuation of intravenous lidocaine infusion.
Topics: Aged; Anesthesia, Local; Arrhythmias, Cardiac; Electrophysiology; Female; Half-Life; Humans; Infusions, Intravenous; Lidocaine; Male; Middle Aged; Time Factors | 1989 |
[High-performance liquid chromatographic method for plasma or serum level monitoring of lidocaine and its active metabolites].
Topics: Chromatography, High Pressure Liquid; Humans; Immunoenzyme Techniques; Lidocaine | 1986 |
Influence of hydralazine on the pharmacokinetics of orally administered d-propranolol and lidocaine in conscious dogs.
Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Drug Combinations; Drug Interactions; Half-Life; Hydralazine; Lidocaine; Propranolol | 1987 |
An enzyme-distributed system for lidocaine metabolism in the perfused rat liver preparation.
Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; In Vitro Techniques; Kinetics; Lidocaine; Liver; Male; Models, Biological; Perfusion; Rats; Rats, Inbred Strains | 1986 |
Serum concentrations and urinary excretion of lidocaine and its two desethylated metabolites after spinal anaesthesia using lidocaine or lidocaine with phenylephrine.
Topics: Aged; Anesthesia, Spinal; Dealkylation; Humans; Injections, Spinal; Kinetics; Lidocaine; Male; Middle Aged; Phenylephrine; Time Factors | 1985 |
Lidocaine disposition in mother, fetus, and neonate after spinal anesthesia.
Topics: Adult; Anesthesia, Spinal; Female; Fetus; Humans; Infant, Newborn; Kinetics; Lidocaine; Pregnancy | 1986 |
Age-dependent lidocaine disposition in patients with acute myocardial infarction.
Topics: Adult; Age Factors; Aged; Body Weight; Chromatography, High Pressure Liquid; Female; Heart Failure; Humans; Infusions, Parenteral; Kinetics; Lidocaine; Male; Middle Aged; Myocardial Infarction; Regression Analysis | 1985 |
Lidocaine plasma concentrations following administration of intraoral lidocaine solution.
Topics: Absorption; Chromatography, Gas; Half-Life; Humans; Kinetics; Lidocaine; Male; Mouth Mucosa; Random Allocation | 1985 |
Plasma concentrations of lidocaine and its principal metabolites during intermittent epidural anesthesia.
Topics: Adult; Anesthesia, Epidural; Castration; Chromatography, High Pressure Liquid; Drug Administration Schedule; Female; Humans; Hysterectomy; Kinetics; Lidocaine; Middle Aged; Models, Biological | 1985 |
Gas-liquid chromatographic estimation of lignocaine, ethylglycylxylidide, glycylxylidide and 4-hydroxyxylidine in plasma and urine.
Topics: Acetanilides; Acetylation; Aniline Compounds; Chromatography, Gas; Drug Stability; Ethylamines; Glycine; Humans; Hydroxylation; Lidocaine | 1974 |
Simultaneous determination of lidocaine and its principal metabolites by liquid chromatography on silica gel, with aqueous eluent.
Topics: Adult; Chromatography, High Pressure Liquid; Female; Fluorescence Polarization; Humans; Immunologic Techniques; Kinetics; Lidocaine | 1984 |
Lipid solubility modulates pH potentiation of local anesthetic block of Vmax reactivation in guinea pig myocardium.
Topics: Action Potentials; Anesthetics, Local; Animals; Electrophysiology; Guinea Pigs; Heart; Hydrogen-Ion Concentration; Kinetics; Lidocaine; Lipids; Membrane Potentials; Octanols; Solubility; Water | 1984 |
Simultaneous determination of lidocaine and its metabolites in plasma and myocardium.
Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Dogs; Female; Lidocaine; Male; Myocardium; Oxidation-Reduction | 1984 |
Penetration of lidocaine and its active desethylated metabolite into cerebrospinal fluid in man.
Topics: Adult; Chromatography, High Pressure Liquid; Humans; Kinetics; Lidocaine; Male | 1983 |
Determination of lidocaine and active metabolites in blood serum by liquid chromatography with electrochemical detection.
Topics: Bupivacaine; Chromatography, Liquid; Electrochemistry; Humans; Lidocaine; Time Factors | 1984 |
Simultaneous determination of lidocaine and its deethylated metabolites using gas-liquid chromatography with nitrogen-phosphorus detection.
Topics: Chromatography, Gas; Humans; Kinetics; Lidocaine; Male; Nitrogen; Phosphorus | 1984 |
Maternal, fetal, and neonatal lidocaine levels following local perineal infiltration.
Topics: Adolescent; Adult; Female; Fetal Blood; Gas Chromatography-Mass Spectrometry; Humans; Infant, Newborn; Kinetics; Lidocaine; Male; Maternal-Fetal Exchange; Pregnancy | 1984 |
Plasma levels, protein binding, and elimination data of lidocaine and active metabolites in cardiac patients of various ages.
Topics: Aged; Aging; Aspartate Aminotransferases; Bilirubin; Biotransformation; Blood Proteins; Creatinine; Female; Heart Diseases; Humans; Kinetics; Lidocaine; Male; Middle Aged; Protein Binding | 1983 |
Plasma concentrations of lignocaine and its metabolites during fibreoptic bronchoscopy.
Topics: Aged; Bronchoscopy; Fiber Optic Technology; Humans; Lidocaine; Middle Aged; Time Factors | 1982 |
Saliva concentrations of lidocaine and its metabolites in man.
Topics: Biotransformation; Humans; Hydrogen-Ion Concentration; Infusions, Parenteral; Lidocaine; Saliva | 1982 |
A rapid analytical procedure for the determination of concentrations of lidocaine and its two active metabolites in canine serum.
Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Lidocaine | 1982 |
Pharmacokinetic principles of lidocaine dosing in relation to disease state.
Topics: Adult; Age Factors; Aged; Animals; Dogs; Drug Therapy, Combination; Half-Life; Heart Failure; Humans; Kidney Diseases; Kinetics; Lidocaine; Liver Diseases; Metabolic Clearance Rate; Middle Aged; Time Factors | 1981 |
Modifications by lidocaine and its N-dealkylated metabolites of the response of the isolated rabbit aorta to transmural electrical stimulation.
Topics: Alkylation; Animals; Aorta, Thoracic; Bretylium Compounds; Calcium; Cocaine; Electric Stimulation; Lidocaine; Male; Muscle Contraction; Norepinephrine; Phentolamine; Potassium; Rabbits | 1980 |
Effect of dehydration and hyperosmolal hydration on lignocaine and metabolites disposition in conscious rabbits.
Topics: Animals; Arginine Vasopressin; Atrial Natriuretic Factor; Dehydration; Dinoprostone; Lidocaine; Male; Osmolar Concentration; Plasma Volume; Rabbits; Renin | 1994 |
Attenuation of antifibrillatory effects of lidocaine by its metabolite, glycylxylidide: application of modulated receptor hypothesis.
Topics: Animals; Dogs; Drug Interactions; Electrophysiology; Lidocaine; Ventricular Fibrillation; Ventricular Function | 1994 |
Sensitive HPLC for simultaneous quantification of lidocaine and its metabolites monoethylglycinexylidide and glycinexylidide in serum.
Topics: Chromatography, High Pressure Liquid; Humans; Lidocaine; Liver Function Tests; Sensitivity and Specificity | 1996 |
First-pass metabolism of lidocaine in the anesthetized rabbit. Contribution of the small intestine.
Topics: Anesthesia; Animals; Aorta, Thoracic; Biotransformation; Epithelium; Injections, Intravenous; Intestine, Small; Jugular Veins; Lidocaine; Liver; Lung; Male; Mesenteric Veins; Rabbits | 1996 |
Toxicity of lidocaine desethyl metabolites.
Topics: Administration, Topical; Anesthetics, Local; Humans; Lidocaine | 1997 |
Effect of plasma alpha1-acid glycoprotein concentration on the accumulation of lidocaine metabolites during continuous epidural anesthesia in infants and children.
Topics: Anesthesia, Epidural; Anesthetics, Local; Child; Child, Preschool; Female; Humans; Infant; Lidocaine; Male; Orosomucoid; Protein Binding | 1999 |
Involvement of liver carboxylesterases in the in vitro metabolism of lidocaine.
Topics: Anesthetics, Local; Animals; Carboxylesterase; Carboxylic Ester Hydrolases; Hydrolysis; Hydroxylation; In Vitro Techniques; Lidocaine; Male; Microsomes, Liver; Rabbits; Rats; Species Specificity; Swine | 2002 |
Chromatographic determination of free lidocaine and its active metabolites in plasma from patients under epidural anesthesia.
Topics: Adult; Anesthesia, Epidural; Anesthetics, Local; Blood Proteins; Chromatography, High Pressure Liquid; Humans; Lidocaine; Male; Middle Aged; Protein Binding; Time Factors | 2002 |
DECREASES IN ARTERIAL OXYGEN SATURATION AND ASSOCIATED CHANGES IN PRESSURES AND ROENTGENOGRAPHIC APPEARANCE OF THE THROAX DURING FORWARD(+GX) ACCELERATION.
Topics: Acceleration; Blood Pressure; Blood Pressure Determination; Lidocaine; Oximetry; Oxygen; Pulmonary Gas Exchange; Radiography, Thoracic; Respiratory Function Tests | 1963 |
DECREASES IN ARTERIAL OXYGEN SATURATION AS AN INDICATOR OF THE STRESS IMPOSED ON THE CARDIORESPIRATORY SYSTEM BY FORWARD ACCELERATION (+GX). TECHN DOCUM REP AMRL-TDR-63-104.
Topics: Acceleration; Biomedical Research; Heart; Lidocaine; Lung; Oximetry; Oxygen; Physiology; Positive-Pressure Respiration; Pulmonary Atelectasis; Pulmonary Circulation; Radiography, Thoracic; Respiration; Stress, Physiological | 1963 |
TOLERANCE TO TRANSVERSE (+GX) AND HEADWARD (+GZ) ACCELERATION AFTER PROLONGED BED REST.
Topics: Acceleration; Bed Rest; Heart; Heart Rate; Humans; Hypoxia; Lidocaine; Physiology; Rest; Vision, Ocular | 1965 |
A RESTRAINT SYSTEM FOR APPLICATION IN RZ AND -GX ACCELERATION ENVIRONMENTS WITH EMPHASIS UPON KNEE AND LOWER LEG RESTRAINTS. AMRL-TR-64-144.
Topics: Acceleration; Gravitation; Humans; Knee; Leg; Lidocaine; Posture | 1964 |
BLOOD OXYGEN CHANGES INDUCED BY FORWARD (+GX) ACCELERATION. AMRL-TR-64-132.
Topics: Acceleration; Animals; Blood; Dogs; Lidocaine; Oximetry; Oxygen; Research | 1964 |
BLOOD OXYGEN CHANGES INDUCED BY FORWARD (+GX) ACCELERATION.
Topics: Acceleration; Anesthesia; Anesthesia, Intravenous; Animals; Blood Gas Analysis; Dogs; Femoral Artery; Lidocaine; Morphine; Oxygen; Pentobarbital; Physiology; Posture; Pulmonary Artery; Research; Respiration | 1965 |
Thrombosis as a conformational disease.
Topics: Adolescent; alpha 1-Antitrypsin; Antithrombins; Body Temperature; Crystallography, X-Ray; Female; Fibrosis; Humans; Lidocaine; Male; Models, Biological; Molecular Conformation; Mutation; Mutation, Missense; Protein Conformation; Protein Structure, Secondary; Thrombosis | 2005 |
[Determination of lidocaine and its metabolites in human plasma by liquid chromatography in combination with tandem mass spectrometry].
Topics: Anesthetics, Local; Chromatography, High Pressure Liquid; Humans; Lidocaine; Tandem Mass Spectrometry | 2010 |
Lidocaine metabolites inhibit glycine transporter 1: a novel mechanism for the analgesic action of systemic lidocaine?
Topics: Anesthetics, Local; Animals; Astrocytes; Blotting, Western; Cerebral Cortex; Female; Glycine; Glycine Plasma Membrane Transport Proteins; Lidocaine; Microglia; Microscopy, Fluorescence; Mitochondria; N-substituted Glycines; Neurons; Oligodendroglia; Oocytes; Patch-Clamp Techniques; Pregnancy; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Xenopus laevis | 2012 |
Lidocaine Intraoperative Infusion Pharmacokinetics during Partial Hepatectomy for Living Liver Donation.
Topics: Hepatectomy; Humans; Lidocaine; Liver | 2023 |
Pharmacokinetics and metabolism of lidocaine HCl 2% with epinephrine in horses following a palmar digital nerve block.
Topics: Anesthetics, Local; Animals; Epinephrine; Horses; Lidocaine; Nerve Block | 2023 |