glyceryl 1,2-dinitrate has been researched along with nitroglycerin in 69 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (27.54) | 18.7374 |
| 1990's | 34 (49.28) | 18.2507 |
| 2000's | 15 (21.74) | 29.6817 |
| 2010's | 1 (1.45) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Koenig, A; Lange, K; Lehmann, J; Roegler, C; Seeling, A | 1 |
| Andersen, MP; Hansen, SH; Jørgensen, M | 1 |
| Brien, JF; Marks, GS; McLaughlin, BE; Nakatsu, K | 1 |
| Banfield, CR; Gonzalez, MA; Huang, YW; Jewell, RC; Noonan, PK; Ruggirello, DA | 1 |
| Benet, LZ; Blaschke, TF; Gumbleton, M; Haefeli, WE; Hoffman, BB | 1 |
| Ahlner, J; Karlberg, KE; Sylvén, C; Torfgård, K | 1 |
| Curry, SH; Green, P; Kwon, HR | 1 |
| Benet, LZ; Guy, RH; Higo, N; Hinz, RS; Lau, DT | 1 |
| Benet, LZ; Lau, DT | 2 |
| Brien, JF; Kawamoto, JH; Marks, GS; McLaughlin, BE; Nakatsu, K | 1 |
| Bauer, KH; Bonn, R; Jähnchen, E; Trenk, D; Wiegand, A | 1 |
| Benet, LZ; Gumbleton, M; Guy, RH; Higo, N; Kikkoji, T | 1 |
| Benet, LZ; Gumbleton, M | 2 |
| Benet, LZ; Gumbleton, M; Labisch, C; Lau, DT | 1 |
| Benet, LZ; Lau, DT; Nakashima, E | 1 |
| Benet, LZ; Lin, ET; Nakashima, E; Rigod, JF | 1 |
| Benet, LZ; Lee, FW; Metzler, CH; Salmonson, T | 1 |
| Iwaki, M; Kanokogi, A; Ogiso, T; Terao, Y | 1 |
| Ahlner, J; Norlander, B; Torfgård, K | 1 |
| Chong, S; Fung, HL | 1 |
| Langseth-Manrique, K | 1 |
| Brien, JF; MacMillan, HF; Marks, GS; McLaughlin, BE; Nakatsu, K | 1 |
| Malta, E | 1 |
| Brien, JF; Kawamoto, J; Marks, GS; McLaughlin, B; Nakatsu, K; Slack, C | 1 |
| Brien, JF; Kawamoto, JH; Kobus, SM; Marks, GS; McLaughlin, BE; Nakatsu, K | 1 |
| Cossum, PA; Roberts, MS | 2 |
| Bennett, BM; Breedon, TH; Brien, JF; Marks, GS; McLaughlin, BE; Nakatsu, K | 1 |
| Bennett, BM; Brien, JF; Kobus, SM; Marks, GS; Nakatsu, K | 1 |
| Cossum, PA; Kilpatrick, D; Roberts, MS; Yong, AC | 1 |
| Dubois, JP; Pommier, F; Sioufi, A | 1 |
| Benet, LZ; Noonan, PK | 1 |
| Benet, LZ; Lee, FW; Rigod, J; Watari, N | 1 |
| Benet, LZ; Noonan, PK; Williams, RL | 1 |
| Andersson, RG; Axelsson, KL; Wikberg, JE | 1 |
| Bennett, BM; Brien, JF; Marks, GS; Nakatsu, K | 1 |
| Lewis, PA; Maddock, J; Rudman, AR; Woodward, AJ | 1 |
| Ahlner, J; Håkansson, E; Svedjeholm, R; Torfgård, KE | 1 |
| Chan, K; Cipriano, A; Joshi, JC; Morgan, JM; Piraino, AJ; Redalieu, E; Sun, JX | 1 |
| Bonn, R; Fritschi, E; Hutt, V; Pabst, G; Sauter, K | 1 |
| Dahl, JB; Jensen, KM | 1 |
| Benet, LZ; Lee, FW; Salmonson, T | 1 |
| Booth, BP; Brien, JF; Cervenko, F; Knight, J; Marks, GS; Milne, B; Nakatsu, K; Pym, J; Rogers, K; Salerno, T | 1 |
| Benet, LZ; Hu, J; Lee, FW; Metzler, CH | 1 |
| Anggard, E; Pistelli, A; Salvemini, D | 1 |
| Booth, BP; Brien, JF; Marks, GS; Nakatsu, K | 1 |
| Bennett, BM; McDonald, BJ | 1 |
| Adachi, T; Fujii, T; Hirano, K; Tatematsu, M; Usami, Y | 1 |
| Brodman, BW; Sharma, A; Sundaram, ST; Zhang, YZ | 1 |
| Blehert, DS; Chambliss, GH; Fox, BG; Knoke, KL | 1 |
| Auclair, B; Ducharme, MP; Ngoc, AH; Sirois, G | 2 |
| Andreyuk, GM; Bezuglov, VV; Kisel, MA; Serkov, IV | 1 |
| Hashimoto, S; Kobayashi, A; Shigemi, K; Tanaka, Y; Tsuruta, H; Yamashita, T; Yamauchi, E | 1 |
| Caplain, H; Gualano, V; Rovati, LC; Santoro, A; Setnikar, I | 1 |
| Caplain, H; Follet, M; Gualano, V; Rovati, LC; Santoro, A; Setnikar, I | 1 |
| Bennett, CL; de la Lande, IS; Horowitz, JD; Phillipov, G; Sage, PR; Stafford, I; Stubberfield, J | 1 |
| Bennett, CL; de la Lande, IS; Horowitz, JD; Siebert, TE; Stafford, I | 1 |
| Chen, Z; Cobb, FR; Stamler, JS; Zhang, J | 1 |
| Fung, HL; Fung, SM; Miyayama, T; Tsou, PS | 1 |
| Harano, Y; Suzuki, M; Takamisawa, I; Yoshimasa, Y | 1 |
| Brandt, M; Bruns, K; Daiber, A; Hink, U; Isse, T; Kawamoto, T; Kleschyov, AL; Lackner, KJ; Lange, K; Lehmann, J; Münzel, T; Oelze, M; Schulz, E; Seeling, A; Steinhoff, L; Weiner, H; Wenzel, P | 1 |
| Adams, MA; Bennett, BM; Friberg, P; Petersson, M; Rundqvist, B | 1 |
| Beretta, M; Goessler, W; Gruber, K; Keung, WM; Koesling, D; Kollau, A; Mayer, B; Russwurm, M; Schmidt, K | 1 |
| Beretta, M; Mayer, B; Schmidt, K; Stessel, H; Wenzl, MV; Wölkart, G | 1 |
| Baral, PK; Beretta, M; Gorren, AC; Gruber, K; Koesling, D; Mayer, B; Russwurm, M; Schmidt, K; Wenzl, MV; Zeller, A | 1 |
| Ghandforoush-Sattari, M; Mashayekhi, S; Valizadeh, H; Zakeri-Milani, P | 1 |
11 trial(s) available for glyceryl 1,2-dinitrate and nitroglycerin
| Article | Year |
|---|---|
Comparison of vasodilatory responses to nitroglycerin and its dinitrate metabolites in human veins.
Topics: Adult; Dose-Response Relationship, Drug; Female; Hand; Humans; Male; Nitroglycerin; Random Allocation; Reference Values; Regression Analysis; Vasodilator Agents; Veins | 1992 |
Pharmacokinetics of nitroglycerin and its metabolites after administration of sustained-release tablets.
Topics: Administration, Oral; Administration, Sublingual; Adult; Biological Availability; Delayed-Action Preparations; Half-Life; Humans; Male; Nitroglycerin; Tablets | 1992 |
Pharmacodynamic and pharmacokinetic evaluation of a new transdermal delivery system with a time-dependent release of glyceryl trinitrate.
Topics: Administration, Cutaneous; Administration, Sublingual; Adult; Blood Pressure; Delayed-Action Preparations; Drug Delivery Systems; Heart Rate; Humans; Male; Nitroglycerin; Single-Blind Method | 1992 |
Tolerance development and arterial and venous tissue-/plasma levels of glyceryl trinitrate and glyceryl dinitrate in patients treated with nitroglycerin infusion.
Topics: Aged; Blood Vessels; Drug Tolerance; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Muscle Contraction; Muscle, Smooth, Vascular; Nitroglycerin; Vasodilator Agents | 1995 |
Comparative pharmacokinetics and bioavailability of nitroglycerin and its metabolites from Transderm-Nitro, Nitrodisc, and Nitro-Dur II systems using a stable-isotope technique.
Topics: Administration, Cutaneous; Biological Availability; Cross-Over Studies; Drug Stability; Humans; Infusions, Intravenous; Male; Nitrogen Isotopes; Nitroglycerin | 1995 |
Bioequivalence evaluation of the metabolites 1,2 and 1,3-glyceryl dinitrate of two different glyceryl trinitrate patches after 12-h usage in healthy volunteers.
Topics: Administration, Cutaneous; Adolescent; Adult; Biotransformation; Cross-Over Studies; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Male; Nitroglycerin; Therapeutic Equivalency; Vasodilator Agents | 1994 |
Plasma concentrations of glyceryl trinitrate and its dinitrate metabolites after sublingual administration to volunteers. Simultaneous determination of glyceryl trinitrate and its dinitrate metabolites.
Topics: Administration, Sublingual; Adult; Biological Availability; Chromatography, Gas; Female; Half-Life; Humans; Male; Nitroglycerin | 1994 |
The pharmacokinetics of trinitroglycerin and its metabolites in patients with chronic stable angina.
Topics: Aged; Aged, 80 and over; Angina Pectoris; Chronic Disease; Female; Humans; Male; Middle Aged; Nitroglycerin; Vasodilator Agents | 2000 |
Bioavailability and pharmacokinetic profile of glyceryl trinitrate and of glyceryl dinitrates during application of a new glyceryl trinitrate transdermal patch.
Topics: Adhesiveness; Administration, Cutaneous; Adult; Area Under Curve; Biological Availability; Cross-Over Studies; Half-Life; Headache; Humans; Male; Nausea; Nitroglycerin; Therapeutic Equivalency; Vasodilator Agents | 2000 |
Plasma levels of glyceryl trinitrate and dinitrates during application of three strengths of a new glyceryl trinitrate transdermal patch.
Topics: Adhesiveness; Administration, Cutaneous; Adult; Area Under Curve; Biological Availability; Cross-Over Studies; Dose-Response Relationship, Drug; Half-Life; Headache; Humans; Male; Nausea; Nitroglycerin; Therapeutic Equivalency; Vasodilator Agents | 2000 |
Nitroglycerin tolerance in human vessels: evidence for impaired nitroglycerin bioconversion.
Topics: Blood Vessels; Coronary Disease; Drug Tolerance; Female; Humans; Infusions, Intravenous; Male; Mammary Arteries; Middle Aged; Nitric Oxide; Nitroglycerin; Saphenous Vein; Superoxides | 2000 |
58 other study(ies) available for glyceryl 1,2-dinitrate and nitroglycerin
| Article | Year |
|---|---|
NO donors. Part 18: Bioactive metabolites of GTN and PETN--synthesis and vasorelaxant properties.
Topics: Animals; Erythrityl Tetranitrate; Nitric Oxide Donors; Nitroglycerin; Pulmonary Artery; Swine; Vasodilation; Vasodilator Agents | 2009 |
Simultaneous determination of nitroglycerin and its dinitrate metabolites by capillary gas chromatography with electron-capture detection.
Topics: Chromatography, Gas; Electrons; Humans; Hydrolysis; Nitroglycerin; Reproducibility of Results | 1992 |
Biotransformation of glyceryl trinitrate by rat brain homogenate.
Topics: Animals; Biotransformation; Brain; Heating; Male; Nitroglycerin; Rats; Rats, Inbred Strains | 1992 |
Dose proportionality of transdermal nitroglycerin.
Topics: Administration, Cutaneous; Adult; Aged; Chromatography, Gas; Female; Humans; Male; Mass Spectrometry; Middle Aged; Nitroglycerin | 1992 |
Dose-dependent effect of intravenous nitroglycerin on platelet aggregation, and correlation with plasma glyceryl dinitrate concentration in healthy men.
Topics: Adult; Dose-Response Relationship, Drug; Filtration; Humans; Injections, Intravenous; Male; Middle Aged; Nitroglycerin; Platelet Aggregation; Platelet Aggregation Inhibitors; Reference Values | 1992 |
Cutaneous metabolism of nitroglycerin in vitro. I. Homogenized versus intact skin.
Topics: Administration, Topical; Animals; Biotransformation; Glutathione Transferase; In Vitro Techniques; Mice; Mice, Hairless; Nitroglycerin; Skin; Skin Absorption | 1992 |
Effects of sulfobromophthalein and ethacrynic acid on glyceryl trinitrate relaxation.
Topics: Animals; Aorta; Ethacrynic Acid; Glutathione Transferase; In Vitro Techniques; Male; Nitroglycerin; Phenylephrine; Rabbits; Sulfobromophthalein; Vasodilation | 1992 |
Biotransformation of glyceryl trinitrate and elevation of cyclic GMP precede glyceryl trinitrate-induced vasodilation.
Topics: Animals; Aorta, Thoracic; Biotransformation; Cattle; Cyclic GMP; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Pulmonary Artery; Pulmonary Veins; Rabbits; Vasodilator Agents | 1990 |
Percutaneous penetration kinetics of nitroglycerin and its dinitrate metabolites across hairless mouse skin in vitro.
Topics: Administration, Cutaneous; Animals; Biotransformation; Chemical Phenomena; Chemistry, Physical; In Vitro Techniques; Mice; Mice, Hairless; Nitroglycerin; Ointments; Skin Absorption; Solubility; Vasodilator Agents | 1991 |
Pharmacological activity of the dinitrate metabolites of nitroglycerin following their oral administration to healthy volunteers.
Topics: Administration, Oral; Adult; Blood Pressure; Humans; Male; Nitroglycerin | 1991 |
Pharmacokinetic studies of the nitroglycerin metabolites, 1,2- and 1,3- glyceryl dinitrates, in the rat.
Topics: Animals; Male; Nitroglycerin; Rats; Rats, Inbred Strains | 1991 |
Variable glyceryl dinitrate formation following infusions of glyceryl trinitrate at different vascular sites in the rat.
Topics: Animals; Femoral Artery; Femoral Vein; Infusions, Intravenous; Jugular Veins; Male; Nitroglycerin; Portal Vein; Rats; Rats, Inbred Strains | 1991 |
Pharmacokinetics of nitroglycerin and its dinitrate metabolites over a thirtyfold range of oral doses.
Topics: Administration, Oral; Administration, Sublingual; Adult; Dose-Response Relationship, Drug; Humans; Male; Nitroglycerin | 1990 |
Pharmacokinetics and pharmacodynamics of glyceryl trinitrate and its two dinitrate metabolites in conscious dogs.
Topics: Administration, Oral; Animals; Dogs; Dose-Response Relationship, Drug; Female; Hemodynamics; Injections, Intravenous; Male; Nitroglycerin | 1990 |
Percutaneous absorption of 1,3-dinitroglycerin and a trial of pharmacokinetic analysis.
Topics: Administration, Topical; Animals; Injections, Intravenous; Nitroglycerin; Rats; Skin Absorption | 1990 |
Simultaneous determination of glyceryl trinitrate and its two dinitrate metabolites in plasma and tissues by capillary gas chromatography.
Topics: Chromatography, Gas; Humans; Nitroglycerin | 1990 |
Differential formation of dinitrate metabolites from glyceryl trinitrate in subcellular fractions of rabbit liver.
Topics: Animals; Cytosol; Glutathione Transferase; Liver; Nitroglycerin; Rabbits; Sulfobromophthalein | 1989 |
Kinetic mechanisms for the concentration dependency of in vitro degradation of nitroglycerin and glyceryl dinitrates in human blood: metabolite inhibition or cosubstrate depletion?
Topics: Animals; Biotransformation; Erythrocytes; Humans; In Vitro Techniques; Male; Methemoglobin; Models, Biological; Nitroglycerin; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Time Factors | 1989 |
Simultaneous determination of glyceryl trinitrate and its metabolites, 1,2- and 1,3-glyceryl dinitrate, in plasma using capillary gas chromatography.
Topics: Chromatography, Gas; Humans; Nitroglycerin | 1989 |
Differential biotransformation of glyceryl trinitrate by red blood cell-supernatant fraction and pulmonary vein homogenate.
Topics: Animals; Biotransformation; Cattle; Chromatography, Thin Layer; Erythrocytes; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Nitroglycerin; Pulmonary Veins; Rabbits | 1989 |
Studies on the biphasic relaxant curve of glyceryl trinitrate in rat aorta: role of GTN metabolites.
Topics: Animals; Aorta, Thoracic; Drug Tolerance; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroglycerin; Oxyhemoglobins; Phenylephrine; Rats; Rats, Inbred Strains | 1989 |
The role of nitric oxide formation in organic nitrate-induced vasodilation and organic nitrate tolerance.
Topics: Animals; Aorta; Biotransformation; Cyclic GMP; Drug Tolerance; Muscle, Smooth, Vascular; Nitric Oxide; Nitroglycerin; Prodrugs; Rabbits; Vasodilation | 1989 |
Mechanism of glyceryl trinitrate-induced vasodilation. I. Relationship between drug biotransformation, tissue cyclic GMP elevation and relaxation of rabbit aorta.
Topics: Animals; Aorta; Biotransformation; Cyclic GMP; Male; Nitroglycerin; Rabbits; Radioimmunoassay; Time Factors; Vasodilation | 1988 |
Metabolite inhibition of nitroglycerin metabolism in sheep tissue homogenates.
Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Depression, Chemical; In Vitro Techniques; Nitroglycerin; Sheep; Time Factors | 1985 |
Biotransformation of glyceryl trinitrate occurs concurrently with relaxation of rabbit aorta.
Topics: Animals; Aorta; Biotransformation; Carbon Radioisotopes; Drug Tolerance; In Vitro Techniques; Male; Nitric Oxide; Nitrites; Nitroglycerin; Rabbits; Vasodilation | 1986 |
Requirement for reduced, unliganded hemoprotein for the hemoglobin- and myoglobin-mediated biotransformation of glyceryl trinitrate.
Topics: Biotransformation; Half-Life; Hemoglobins; Methemoglobin; Metmyoglobin; Myoglobin; Nitrites; Nitroglycerin; Oxidation-Reduction | 1986 |
Distribution and metabolism of nitroglycerin and its metabolites in vascular beds of sheep.
Topics: Animals; Blood Vessels; Dose-Response Relationship, Drug; Hemodynamics; Kinetics; Liver; Lung; Metabolic Clearance Rate; Nitroglycerin; Sheep | 1986 |
Determination of the two dinitrate metabolites of nitroglycerin in human plasma by capillary gas chromatography with electron-capture detection.
Topics: Chromatography, Gas; Electrochemistry; Humans; Indicators and Reagents; Kinetics; Nitroglycerin | 1987 |
Variable glyceryl dinitrate formation as a function of route of nitroglycerin administration.
Topics: Administration, Oral; Administration, Topical; Humans; Infusions, Intravenous; Kinetics; Male; Nitroglycerin | 1987 |
Simultaneous determination of nitroglycerin and its dinitrate metabolites by capillary gas chromatography with electron-capture detection.
Topics: Animals; Chromatography, Gas; Dogs; Electrochemistry; Gas Chromatography-Mass Spectrometry; Humans; Indicators and Reagents; Nitroglycerin; Solvents | 1988 |
Dose dependent pharmacokinetics of nitroglycerin after multiple intravenous infusions in healthy volunteers.
Topics: Adsorption; Blood Vessels; Dose-Response Relationship, Drug; Half-Life; Humans; Infusions, Parenteral; Kinetics; Metabolic Clearance Rate; Nitroglycerin; Time Factors | 1985 |
Nitroglycerin disposition in human blood.
Topics: Biotransformation; Blood Proteins; Erythrocytes; Half-Life; Humans; Nitroglycerin; Plasma; Protein Binding; Time Factors | 1985 |
Correlation between vascular smooth muscle relaxation and increase in cyclic GMP induced by some organic nitro esters.
Topics: Animals; Cattle; Cyclic AMP; Cyclic GMP; Dose-Response Relationship, Drug; Ethylene Glycols; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitro Compounds; Nitroglycerin | 1981 |
Biotransformation of glyceryl trinitrate to glyceryl dinitrate by human hemoglobin.
Topics: Adult; Biotransformation; Erythrocytes; Hemoglobins; Humans; In Vitro Techniques; Male; Nitroglycerin; Oxidation-Reduction | 1984 |
Determination of nitroglycerin and its dinitrate metabolites in human plasma by high-performance liquid chromatography with thermal energy analyzer detection.
Topics: Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Humans; Nitroglycerin; Time Factors | 1984 |
Simultaneous pharmacodynamic modeling of the non-steady-state effects of three oral doses of 1,3-glyceryl dinitrate upon blood pressure in healthy volunteers.
Topics: Administration, Oral; Adult; Blood Pressure; Humans; Male; Nitroglycerin; Vasodilator Agents | 1993 |
Pharmacokinetics and pharmacodynamics of nitroglycerin and its dinitrate metabolites in conscious dogs: intravenous infusion studies.
Topics: Animals; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Female; Half-Life; Infusions, Intravenous; Nitroglycerin; Vasodilator Agents | 1993 |
The effects of hypothermic and normothermic cardiopulmonary bypass on glyceryl trinitrate activity.
Topics: Aged; Cardiopulmonary Bypass; Elective Surgical Procedures; Female; Humans; Hypothermia, Induced; Male; Middle Aged; Nitroglycerin; Vasodilator Agents | 1994 |
Nitroglycerin dinitrate metabolites do not affect the pharmacokinetics and pharmacodynamics of nitroglycerin in the dog: a preliminary report.
Topics: Animals; Blood Pressure; Chromatography, Gas; Dogs; Drug Interactions; Electrochemistry; Female; Hemodynamics; Infusions, Intravenous; Injections, Intravenous; Male; Nitroglycerin; Vasodilator Agents | 1993 |
Vascular and anti-platelet actions of 1,2- and 1,3-glyceryl dinitrate.
Topics: Acetylcysteine; Animals; Benzoates; Biotransformation; Blood Platelets; Cattle; Drug Synergism; Endothelium, Vascular; Humans; In Vitro Techniques; Muscle, Smooth, Vascular; Nitric Oxide; Nitrites; Nitroglycerin; Platelet Aggregation; Platelet Aggregation Inhibitors; Rabbits; Sulfhydryl Compounds; Thimerosal; Vasodilator Agents | 1993 |
Effect of temperature on glyceryl trinitrate induced relaxation of rabbit aorta.
Topics: Animals; Aorta; Biotransformation; Culture Media; Hot Temperature; In Vitro Techniques; Male; Nitric Oxide; Nitroglycerin; Rabbits; Vasodilation; Vasodilator Agents | 1993 |
Biotransformation of glyceryl trinitrate by rat aortic cytochrome P450.
Topics: Animals; Aorta; Biotransformation; Carbon Monoxide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Kinetics; Microsomes; Microsomes, Liver; Nitroglycerin; Oxygen; Phenobarbital; Proadifen; Rats | 1993 |
Variable glyceryl dinitrate formation as a function of glutathione S-transferase.
Topics: Amino Acid Sequence; Animals; Glutathione Transferase; Nitroglycerin; Swine; Vasodilator Agents | 1996 |
Biodegradation of glyceryl trinitrate by Penicillium corylophilum Dierckx.
Topics: Biodegradation, Environmental; Biomass; Equipment Contamination; Glucose; Nitrates; Nitroglycerin; Penicillium; Water | 1997 |
Regioselectivity of nitroglycerin denitration by flavoprotein nitroester reductases purified from two Pseudomonas species.
Topics: Anaerobiosis; Bacteriological Techniques; Culture Media; Flavoproteins; Isomerism; Kinetics; NADP; Nitrites; Nitrogen; Nitroglycerin; Oxidation-Reduction; Oxidoreductases; Pseudomonas | 1997 |
Novel pharmacokinetic modelling of transdermal nitroglycerin.
Topics: Administration, Cutaneous; Adult; Canada; Chromatography, High Pressure Liquid; Drug Delivery Systems; Humans; Male; Models, Biological; Nitroglycerin; Vasodilator Agents | 1998 |
Population pharmacokinetics of nitroglycerin and of its two metabolites after a single 24-hour application of a nitroglycerin transdermal matrix delivery system.
Topics: Administration, Cutaneous; Adolescent; Adult; Humans; Models, Biological; Nitroglycerin; Time Factors; Vasodilator Agents | 1998 |
Influence of dinitroglycerol and nitroethyleneglycol lipid derivatives on spectral parameters of human hemoglobin.
Topics: Ethylene Glycols; Hemoglobins; Humans; Nitroglycerin; Spectrophotometry, Ultraviolet | 2000 |
Influence of the endothelium on ex vivo tolerance and metabolism of glyceryl trinitrate in rat aorta.
Topics: Animals; Aorta; Chromatography, Gas; Drug Tolerance; Endothelium, Vascular; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroglycerin; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 2004 |
Role of mitochondrial aldehyde dehydrogenase in nitroglycerin-induced vasodilation of coronary and systemic vessels: an intact canine model.
Topics: Adenosine; Aldehyde Dehydrogenase; Animals; Biotransformation; Blood Pressure; Coronary Circulation; Cyanamide; Cyclic GMP; Diastole; Dogs; Mitochondria; Nitrites; Nitroglycerin; Nitroprusside; Vasodilation | 2004 |
Simultaneous determination of nitroglycerin and dinitrate metabolites in metabolism studies using liquid chromatography-mass spectrometry with electrospray ionization.
Topics: Ammonium Chloride; Animals; Chromatography, High Pressure Liquid; Humans; LLC-PK1 Cells; Muscle, Smooth, Vascular; Nitroglycerin; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Swine | 2006 |
Association between insulin resistance and endothelial dysfunction in type 2 diabetes and the effects of pioglitazone.
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Nitroglycerin; Pioglitazone; Thiazolidinediones; Vasodilation | 2007 |
Number of nitrate groups determines reactivity and potency of organic nitrates: a proof of concept study in ALDH-2-/- mice.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Blotting, Western; Cell Adhesion Molecules; Cyclic GMP-Dependent Protein Kinases; Isometric Contraction; Luminescence; Mass Spectrometry; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins; Mitochondria, Muscle; Nitrates; Nitroglycerin; Nitroprusside; Oxadiazoles; Pentaerythritol Tetranitrate; Phosphoproteins; Quinoxalines; Structure-Activity Relationship; Vasodilator Agents | 2007 |
Impaired nitroglycerin biotransformation in patients with chronic heart failure.
Topics: Adult; Biotransformation; Chronic Disease; Heart Failure; Humans; Male; Middle Aged; Nitroglycerin; Vasodilator Agents | 2008 |
Bioactivation of nitroglycerin by purified mitochondrial and cytosolic aldehyde dehydrogenases.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Aldehyde Dehydrogenase, Mitochondrial; Animals; Catalysis; Cattle; Cyclic GMP; Cytosol; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Mitochondria; Muscle, Smooth, Vascular; Nitroglycerin; Protein Isoforms; Retinal Dehydrogenase; Serum Albumin | 2008 |
Different effects of ascorbate deprivation and classical vascular nitrate tolerance on aldehyde dehydrogenase-catalysed bioactivation of nitroglycerin.
Topics: Aldehyde Dehydrogenase; Animals; Ascorbic Acid; Ascorbic Acid Deficiency; Biotransformation; Chloral Hydrate; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drug Tolerance; Enzyme Activation; Enzyme Inhibitors; Female; Guinea Pigs; Hydrazines; Injections, Subcutaneous; Isoflavones; Male; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Time Factors; Vasodilation; Vasodilator Agents | 2009 |
Role of the general base Glu-268 in nitroglycerin bioactivation and superoxide formation by aldehyde dehydrogenase-2.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Cattle; Escherichia coli; Guanylate Cyclase; Humans; Lung; NAD; Nitric Oxide; Nitroglycerin; Point Mutation; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase; Superoxide Dismutase; Superoxides | 2009 |
Determination of glyceryl trinitrate and its two main metabolites in human plasma using a new sensitive gas chromatography method.
Topics: Administration, Cutaneous; Adult; Area Under Curve; Biological Availability; Biotransformation; Calibration; Chromatography, Gas; Humans; Male; Nitroglycerin; Reproducibility of Results; Solvents; Therapeutic Equivalency; Vasodilator Agents; Young Adult | 2011 |