glyburide has been researched along with tolbutamide in 416 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 196 (47.12) | 18.7374 |
| 1990's | 121 (29.09) | 18.2507 |
| 2000's | 63 (15.14) | 29.6817 |
| 2010's | 35 (8.41) | 24.3611 |
| 2020's | 1 (0.24) | 2.80 |
| Authors | Studies |
|---|---|
| Dietrich, H; Lehmann, C; Märki, F; Schweizer, EH | 1 |
| Aguilar-Bryan, L; Bryan, J; Clement, JP; Gonoi, T; Gonzalez, G; Inagaki, N; Inazawa, J; Namba, N; Seino, S | 1 |
| Higashiguchi, O; Horio, Y; Isomoto, S; Kondo, C; Kurachi, Y; Matsumoto, S; Matsuzawa, Y; Yamada, M | 1 |
| Hashimoto, Y; Inui, K; Saito, H; Uwai, Y | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Abe, T; Itoh, T; Kato, Y; Kusuhara, H; Meier, PJ; Shitara, Y; Sugiyama, D; Sugiyama, Y | 1 |
| Koyabu, N; Murakami, H; Ohtani, H; Satoh, H; Sawada, Y; Tsujimoto, M; Yamashita, F | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Andricopulo, AD; Moda, TL; Montanari, CA | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Buttar, D; Colclough, N; Gerhardt, S; MacFaul, PA; Maskos, K; Phillips, SD; Plowright, A; Steinbacher, S; Steuber, H; Tam, K; Whittamore, P | 1 |
| Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S | 1 |
| Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Cho, YS; Hwang, EM; Jung, SY; Lim, SM; Min, SJ; Pae, AN; Park, KD; Viswanath, AN | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Melander, A; Wåhlin-Boll, E | 2 |
| Codina, J; Herrera, E; Lasuncion, MA | 1 |
| Balant, L | 1 |
| Alemany, M; Herrera, E; Remesar, X | 1 |
| Bickel, M; Geisen, K; Schleyerbach, R | 1 |
| Alemany, M; Codina, J; Herrera, E; Palou, A | 1 |
| Alemany, M; Herrera, E; Palou, A | 1 |
| Castoldi, D; Tofanetti, O | 1 |
| Hasselblatt, A; Joost, HG | 1 |
| Efendic, S; Lundberg, JM; Uvnäs, B; Uvnäs-Wallensten, K | 1 |
| Bottermann, P; Lüders, L; Zilker, T | 1 |
| Gotfredsen, CF | 1 |
| Haslbeck, M | 1 |
| Macchi, IA; Zeytinoğlu, FN | 1 |
| Cerasi, E; Grill, V | 1 |
| Handler, JS; Keiser, HR; Zusman, RM | 1 |
| Brooker, G; Linden, J | 1 |
| Grill, V | 1 |
| Foy, JM; Lucas, PD | 1 |
| Christensen, LK; Hansen, JM | 1 |
| Bloom, A; Bulpitt, CJ; Shaw, KM | 1 |
| Jorgensen, KD | 2 |
| Di Saverio, S; Roncaia, R; Torri, A; Zanni, A | 1 |
| Balant, L; Fabre, J; Loutan, L; Samimi, H; Tillolès, M | 1 |
| Pfeiffer, EF; Schatz, H; Steinle, D | 1 |
| Hausmann, L; Kaffarnik, H; Schumann, G | 1 |
| Kamenisch, W; Laube, H; Pfeiffer, EF; Schatz, H; Sieradzki, J | 1 |
| Greenstein, S; Kashyap, RP; Walfish, PG | 1 |
| Hoder, A; Losert, W; Scholz, C | 1 |
| Hassalacher, Ch; Lang, PD; Vollmar, J; Wahl, P | 1 |
| Bennett, MA; Fitzgerald, MG; Malins, JM; Pentecost, BL; Soler, NG | 1 |
| Blumenbach, L; Gerhards, E; Gutsche, H; Klein, W; Loge, O; Losert, W; Schillinger, E; Speck, U; Vetter, H; Wendt, H | 1 |
| Krause, U; Puchinger, H; Wacker, A | 2 |
| Willms, B | 1 |
| Nierle, C; Pfeiffer, EF; Schatz, H | 1 |
| Baumeister, G; Stahl, M; Wagner, H | 1 |
| O'Connor, C; Pascual Leone, A; Valdés, M | 1 |
| Andreev, D; Pampulov, L | 1 |
| Baumeister, G; Stahl, M; Wagner, H; Zierden, E | 1 |
| Müller, WE; Wollert, U | 1 |
| Brown, KF; Crooks, MJ | 2 |
| Alric, R; Loubatières, AL; Loubatieres-Mariani, MM; Ribes, G; Sorial, G; Tarasco, A | 1 |
| Alric, R; Lignon, F; Loubatières, A; Manteghetti, M; Puech, R | 1 |
| Balabolkin, MI; Danilova, TI; Ol'shanskaia, AA; Timofeev, AV; Zhuleva, LIu | 1 |
| Ambrosi, F; Cristallini, S; Filipponi, P; Gregorio, F; Pedetti, M; Santeusanio, F | 1 |
| de Hemptinne, A; Vanheel, B | 1 |
| Auchampach, JA; Cavero, I; Gross, GJ; Maruyama, M | 1 |
| Ferguson, PW; Judd, RL; Kunjathoor, VV; Medon, PJ; Pillai, UA | 1 |
| Kozlowski, RZ; Nye, PC; Robertson, BE | 1 |
| Buscema, M; Caltabiano, V; Forte, F; Purrello, F; Rabuazzo, AM; Vetri, M; Vigneri, R; Vinci, C | 1 |
| Henderson, G; Hicks, GA | 1 |
| Antunes, CM; Barbosa, RM; Rosario, LM; Santos, RM; Silva, AM | 1 |
| Findlay, I | 3 |
| Haddad, GG; Jiang, C; Xia, Y | 1 |
| Bernardi, H; Fosset, M; Lazdunski, M | 1 |
| Aguilar-Bryan, L; Bryan, J; Nelson, DA | 1 |
| Katsumata, K; Katsumata, Y | 3 |
| Aoki, M; Inoue, H; Kaku, K; Kaneko, T; Matsuda, M | 1 |
| Cooper, GJ; Moore, CX | 1 |
| Bosco, D; Chanson, M; Giordano, E; Meda, P; Soria, B | 1 |
| Harrower, AD | 1 |
| Fu, SX; Li, YS; Yang, XP; Zhang, HL | 1 |
| Ammälä, C; Arkhammar, P; Berggren, PO; Bokvist, K; Larsson, O; Rorsman, P; Wåhlander, K | 1 |
| Cooper, DR; Farese, RV; Ishizuka, T; Standaert, ML | 1 |
| Collier, BH; D'Souza, MJ; Pollock, SH; Reichbaum, MI | 1 |
| Nishikawa, M; Sato, Y; Shinkai, H; Sukegawa, E | 1 |
| Buscema, M; Gatta, C; Gullo, D; Purrello, F; Rabuazzo, AM; Vetri, M; Vigneri, R; Vinci, C | 1 |
| Ashcroft, SJ; Berggren, PO; Hubbard, P; Niki, I; Welsh, M | 1 |
| Lamp, ST; Venkatesh, N; Weiss, JN | 1 |
| Kanno, M; Nakaya, H; Takeda, Y; Tohse, N | 1 |
| Chang, CC; Hong, SJ | 1 |
| Garrino, MG; Henquin, JC | 1 |
| Aranyi, Z; Ballagi-Pordány, G; Koltai, MZ; Köszeghy, A; Pogátsa, G | 1 |
| Pilsudski, R; Rougier, O; Tourneur, Y | 1 |
| Boutagy, JS; Shenfield, GM; Webb, C | 1 |
| Cooper, DR; Farese, RV; Nair, G; Pollet, RJ; Standaert, M; Vila, MC; Watson, JE | 1 |
| Antoine, MH; Berkenboom, G; Fang, ZY; Fontaine, J; Herchuelz, A; Hermann, M; Lebrun, P | 1 |
| Krnjević, K | 1 |
| Dash, RJ; Khandekar, S; Sethi, BK | 1 |
| Ashford, ML; Boden, PR; Treherne, JM | 1 |
| Gasser, RN; Vaughan-Jones, RD | 1 |
| Angus, JA; Cocks, TM; King, SJ | 1 |
| Ashford, ML; Cook, DL; Hales, CN; Sturgess, NC | 1 |
| Abrahamsson, H; Berggren, PO; Rorsman, P | 1 |
| Ohno-Shosaku, T; Rorsman, P; Trube, G | 1 |
| Rosario, LM | 1 |
| Castle, NA; Haylett, DG | 1 |
| Lenzen, S; Männer, K; Panten, U; Trube, G; Zünkler, BJ | 1 |
| Wilson, C | 1 |
| Pfeifer, MA; Rothschild, AH; Rothschild, MA | 1 |
| Anderson, EG; Grigg, JJ | 1 |
| Brayden, JE; Davies, NW; Huang, Y; Nelson, MT; Quayle, JM; Standen, NB | 1 |
| Faivre, JF; Findlay, I | 1 |
| Sanguinetti, MC; Siegl, PK; Wolleben, CD | 1 |
| Falke, LC; Gee, WM; Gillis, KD; Hammoud, A; McDaniel, ML; Misler, S | 1 |
| Ashcroft, FM; Ashcroft, SJ; Kelly, RP; Niki, I | 1 |
| Bartosiewicz, W; Czyzyk, A; Lao, B; Orłowska, K; Szczepanik, Z | 1 |
| van Koetsveld, PM; Verschoor, L; Weber, RF; Weeks, L; Wolffenbuttel, BH | 1 |
| Herchuelz, A; Lebrun, P; Malaisse, WJ | 1 |
| Inaba, M; Inoue, A; Morii, H; Nishizawa, Y; Okuno, S | 1 |
| Gepts, W; Gorus, FK; In't Veld, PA; Pipeleers, DG; Schuit, FC | 1 |
| Anselmi, E; D'Ocon, MP; Ivora, MD; Villar, A | 1 |
| Blas, SD; Davis, FB; Davis, PJ; Mylotte, KM; Warnick, PR | 1 |
| Berg, M; Boyd, AE; Gaines, KL; Nelson, TY; Rajan, AS | 1 |
| Anselmi, E; D'Ocon, MP; Villar, A | 1 |
| Patel, TB | 1 |
| Anselmi, E; D'Ocon, MP; Ivorra, MD; Villar, A | 1 |
| Kimura, S; Mine, T; Ogata, E; Ohsawa, H | 1 |
| Kar, RN; Mukherjee, B; Mukherjee, SK | 1 |
| Cook, GA | 1 |
| Kaku, K; Kaneko, T; Matsuda, M | 1 |
| Dyson, J; Patel, TB; Rashed, HM; Waller, FM | 1 |
| Pollet, RJ; Rogers, BJ; Standaert, ML | 1 |
| Anselmi, E; Ivorra, MD; Villar, A | 1 |
| Boyd, AE; Gaines, KL; Hamilton, S | 1 |
| Morita, K; Murakumo, Y; Nakanishi, A; Oka, M; Teraoka, K | 1 |
| Patel, TB; Rashed, HM; White, CW | 1 |
| Ashford, ML; Carrington, CA; Hales, CN; Kozlowski, RZ; Sturgess, NC | 1 |
| Matsuyama, E; Nakahara, Y; Tamura, T | 1 |
| Malaisse, WJ; Malaisse-Lagae, F; Mathias, PC; Sener, A | 1 |
| Boyajy, LD; Hanson, RL; Isaacson, CM | 1 |
| Colombo, R; Pinelli, A; Tofanetti, O; Trivulzio, S; Zecca, L | 1 |
| Balkányi, I; Dévai, J; Kiss, V; Koltai, MZ; Pogátsa, G | 1 |
| Hatao, K; Kaku, K; Kaneko, T; Matsuda, M; Tsuchiya, M | 1 |
| Ravina, A | 1 |
| Reinwein, D | 1 |
| Beyer, J; Cordes, U; Haupt, E; Kutschera, J; Schöffling, K | 1 |
| Hellman, B; Sehlin, J; Täljedal, IB | 2 |
| Beyer, J; Cordes, U; Haupt, E; Köberich, W; Rosak, C; Schöffling, K | 1 |
| Bartelt, KM; Beyer, J; Haupt, E; Rosak, C; Schöffling, K | 1 |
| Gey, KF; Lorch, E; Sommer, P | 1 |
| Beyer, J; Cordes, U; Schöffling, K; Sell, G | 1 |
| Beyer, J; Gather, W; Schöffling, K | 1 |
| Beyer, J; Haupt, E; Köberich, W; Rosak, C; Schöffling, K | 1 |
| Beyer, J; Cordes, U; Haupt, E; Köberich, W; Schöffling, K | 2 |
| Ashcroft, SJ; Randle, PJ; Weerasinghe, LC | 1 |
| Jackson, WP; Keller, P; Van Mieghem, W | 1 |
| Foy, JM; Standing, VF | 1 |
| Pfeiffer, EF; Raptis, S; Rothenbuchner, G | 1 |
| Bosboom, RS; Bouman, PR; Zweens, J | 1 |
| Daweke, H; Fähndrich, W; Liebermeister, H; Schmitt, H | 1 |
| Stowers, JM | 1 |
| Botros, M; Ghareeb, A; Ghoneim, K; Selim, R; Wahba, N | 1 |
| Addah, SA; Crockford, PM; Powell, P | 1 |
| Beyer, J; Cordes, U; Haupt, E; Schöffling, K; Sell, G | 2 |
| de Baere, H; de Leeuw, I; Decraene, P; Lemmens, P; Verhaegen, H | 1 |
| Beyer, J; Haupt, E; Schöffling, K | 2 |
| Hsu, PL; Luzzi, LA; Ma, JK | 1 |
| Beyer, J; Happ, J; Haupt, E; Jungmann, E; Scherer, U; Schöffling, K | 1 |
| Ide, T; Kajinuma, H; Kuzuya, TT | 1 |
| Dunbar, JC; Foà, PP | 1 |
| Loubatières, A; Loubatières-Mariani, MM | 1 |
| Okajima, J | 1 |
| Kar, BC; Panda, NC; Parija, CR; Tej, SC; Tripathy, BB | 1 |
| Täljedal, IB | 1 |
| Pfeiffer, EF; Raptis, S; Schröder, KE | 1 |
| Hellman, B | 1 |
| Hasselblatt, A; Panten, U; Poser, W; Schönborn, J | 1 |
| Mughini, L; Polosa, P | 1 |
| Heine, P; Kewitz, H; Schnapperelle, U | 1 |
| Beringer, A | 1 |
| Althoff, PH; Beyer, J; Fröhlich, A; Happ, J; Nest, E; Schöffling, K | 1 |
| Bavel'skii, ZE; Kuts, LG; Lazaris, YA | 1 |
| Beyer, J; Haupt, E; Rosak, C; Schöffling, K | 1 |
| Aziz, MT; Einen, MA; el-Ebrashy, N; Higazi, AM; Mashaly, M | 1 |
| Leupold, H | 1 |
| Loubatiéres, A; Mariani, MM | 1 |
| Chapal, J; Loubathières, A; Mariani, MM; Ribes, G | 1 |
| Heine, P; Kewitz, H; Wiegboldt, KA | 1 |
| Adadevoh, BK; Bolodeoku, JO | 1 |
| Jeanrenaud, B; Kanazawa, Y; Lambert, AE; Orci, L; Renold, AE | 1 |
| Howell, SL; Montague, W | 1 |
| Lundquist, I | 1 |
| Ebert, R; Hillebrandt, O; Schwabe, U | 1 |
| Bird, GW; Eeles, GH; Litchfield, JA; Rahman, M; Wingham, J | 1 |
| Kewitz, H | 1 |
| Parodi, FA | 1 |
| Pfeiffer, EF; Raptis, S | 1 |
| Mitra, D; Mutalik, GS; Nayak, NJ; Oak, VR | 1 |
| Cacciari, E; Cicognani, A; Collina, A; Pirazzoli, P; Tassoni, P | 1 |
| Dörfler, H; Wolfram, G; Zöllner, N | 1 |
| Cheah, JS | 1 |
| Bloom, A | 1 |
| Hinz, M; Maier, V; Nierle, C; Pfeiffer, EF; Schatz, H | 1 |
| Love, AH; Teale, JD | 1 |
| Beyer, J; Haupt, E; Köberich, W; Schöffling, K | 3 |
| Tjioe, TO; Wacker, A | 1 |
| Beyer, J; Ewald, W; Haupt, E; Mehnert, H; Nemeth, N; Schöffling, K; Wicklmayr, M | 1 |
| Loubatières, A | 1 |
| Sigroth, K; Steen, B; Svanborg, A | 1 |
| Marble, A | 1 |
| Hasslacher, C; Wahl, P | 1 |
| Creutzfeldt, W; Scheler, F; Wigger, W | 1 |
| Chandra, P; Wacker, A; Wacker, D | 1 |
| Madsen, SN; Persson, I | 1 |
| Bürkle, PA; Federlin, K; Hemm, G; Huber, V | 1 |
| Consiglio, D; Hopps, V; Mantia, G | 1 |
| Bänder, A | 1 |
| Müller, R | 1 |
| Schöffling, K | 1 |
| Brauch, K; Haslbeck, M; Hepp, KD; Mehnert, H | 1 |
| Brunetti, P; Filipponi, P; Marcelli, M; Nicoletti, I; Pacifici, R; Santeusanio, F | 1 |
| Kanatsuka, A; Kumagai, A; Makino, H; Osegawa, M | 1 |
| Abdel-Hamid, M; Ammon, HP; Enz, G; Rao, PG | 1 |
| Altszuler, N; Cherksey, B | 1 |
| Kimura, M; Suzuki, J | 1 |
| Deleers, M; Lebrun, P; Malaisse, WJ | 1 |
| Norlund, L; Sehlin, J | 1 |
| Matthews, EK; Shotton, PA | 1 |
| Gylfe, E; Hellman, B; Sehlin, J; Täljedal, B | 1 |
| Tattersall, RB | 1 |
| Whitney, JE; Yelich, MR | 1 |
| Loubatieres-Mariani, MM | 1 |
| Melander, A; Sartor, G; Scherstén, B; Wåhlin-Boll, E | 2 |
| Feldman, JM; Skillman, TG | 1 |
| Lisch, HJ; Sailer, S | 1 |
| Lohmann, D; Verlohren, HJ | 1 |
| Gonnermann, B; Gustson, D; Schatz, H | 1 |
| Annamala, PT; Augusti, KT | 1 |
| Pados, G | 1 |
| Appel, S; Hitzenberger, G; Kalafsky, G; Kallay, Z; Kutz, K; Rüfenacht, T; Tetzloff, W | 1 |
| Dubinsky, WP; Mayorga-Wark, O; Schultz, SG | 1 |
| Broadway, NM; Saggerson, ED | 1 |
| Adogu, AA; Ashford, ML; Hales, CN; Khan, RN; Ozanne, SE | 1 |
| Lacey, MG; Stanford, IM | 1 |
| Do, ML; Halterman, TJ; Howe, BB; Kau, ST; Li, JH; McConville, MW; Trivedi, S; Yochim, CL; Zografos, P | 1 |
| Chudziak, F; Dickel, C; Moshiri, A; Panten, U; Schwanstecher, C; Schwanstecher, M | 1 |
| Erdemli, G; Krnjević, K | 2 |
| Krishnaiah, YS; Satyanarayana, S; Visweswaram, D | 1 |
| Ballanyi, K; Richter, DW; Trapp, S | 1 |
| Cahill, AL; Perlman, RL | 1 |
| Ashford, ML; Hales, CN; Lee, K; Ozanne, SE | 1 |
| Auchampach, JA; Gross, GJ; Pieper, GM; Yao, Z | 1 |
| Bachmann, C; Chudziak, F; Löser, S; Panten, U; Schwanstecher, M | 1 |
| Ashford, ML; Hales, CN; Lee, K; Ozanne, SE; Rowe, IC | 1 |
| Elliott, BD; Johnson, R; Langer, O; Prihoda, T; Schenker, S | 1 |
| Godfraind, JM; Krnjević, K | 1 |
| Baró, I; Berthon, B; Escande, D; Hongre, AS | 1 |
| Kruseman, AC; Menheere, PP; Müller, PG; Nijst, L; Sels, JP; Wolffenbuttel, BH | 1 |
| Comtois, A; Kong, M; Light, P; Renaud, JM | 1 |
| Buettger, C; Epstein, AJ; Hang, TL; Matschinsky, FM; Ronner, P | 1 |
| Freedman, JE; Greif, GJ; Lin, YJ | 1 |
| Fox, AP; Kelly, JS; Penington, NJ | 1 |
| Ashcroft, SJ; Niki, I | 1 |
| Nakaya, H | 1 |
| Finta, EP; Fischer, HD; Harms, L; Illes, P; Sevcik, J | 1 |
| Cohen, RA; Cowan, CL; Najibi, S; Palacino, JJ | 1 |
| Krnjević, K; Zhu, PJ | 1 |
| Arkhammar, P; Berggren, PO; Bokvist, K; Hallberg, A; Nilsson, T; Rorsman, P; Sjöholm, A; Welsh, M; Welsh, N | 1 |
| Ben-Ari, Y; Crépel, V; Krnjević, K | 1 |
| Frey, G; Hanke, W; Schlue, WR | 1 |
| Broillet, MC; Horisberger, JD | 1 |
| Katsumata, K; Katsumata, Y; Ozawa, T | 1 |
| Van Wagoner, DR | 1 |
| Elford, BC; Horner, HA; Kirk, K; Spillett, DJ | 1 |
| Ammälä, C; Berggren, PO; Bertorello, AM; Bokvist, K; Chibalin, A; Deeney, JT; Eliasson, L; Flatt, PR; Gäbel, J; Gromada, J; Larsson, O; Lindström, P; Renström, E; Rhodes, CJ; Rorsman, P | 1 |
| Gross, AS; Rieutord, A; Shenfield, GM; Stupans, I | 1 |
| Hara, T; Hotta, N; Koh, N; Nakamura, J; Sakakibara, F; Takeuchi, N | 1 |
| Bischoff, AM; Pierrefiche, O; Richter, DW | 1 |
| Garcia-Barrado, MJ; Gilon, P; Henquin, JC; Jonas, JC | 1 |
| Bijlstra, PJ; Lutterman, JA; Russel, FG; Smits, P; Thien, T | 1 |
| Ballanyi, K; Brockhaus, J; Doutheil, J | 1 |
| Howes, LG; Lykos, D; Sundaresan, P | 1 |
| Selvaag, E | 1 |
| Gagliardino, JJ; García, ME; Rossi, PF | 1 |
| Abenhaim, L; Monette, J; van Staa, T | 1 |
| Brownhill, V; Lee, K; Richardson, PJ | 1 |
| Akaike, N; Ishibashi, H; Koyama, S; Murai, Y | 1 |
| Fullerton, DA; McIntyre, RC; Meldrum, DR; Sheridan, BC | 1 |
| Koyama, H; Mori, S; Nakajima, K; Sugioka, N; Uno, A | 1 |
| Luo, M; O'Brien, RC | 1 |
| Kitagawa, T; Nitadori, Y; Owada, M | 1 |
| Bernardi, G; Federici, M; Guatteo, E; Knöpfel, T; Mercuri, NB; Siniscalchi, A | 1 |
| Kikuchi, M; Niki, I; Oka, Y; Sakurada, M; Tsukuda, K | 1 |
| Haller, M; Langohr, K; Mironov, SL; Richter, DW | 1 |
| Chan, TY | 1 |
| Dixon, AK; Freeman, TC; Lee, K; Richardson, PJ | 1 |
| Ashcroft, FM; Gribble, FM; Seino, S; Tucker, SJ | 1 |
| Ashcroft, SJ; Johnson, G; Tian, YA | 1 |
| Aguilar-Bryan, L; Babenko, AP; Bryan, J; Gonzalez, G | 1 |
| Benington, S; Best, L | 1 |
| Bernardi, G; Calabresi, P; Centonze, D; Marfia, GA; Pisani, A | 1 |
| Ikeda, T; Ochi, H | 1 |
| Chagneau, C; De Gottardi, A; Fléjou, JF; Fouassier, L; Housset, C; Lahaye, P; Lebrec, D; Moreau, R; Reichen, J; Rona, JP; Tazi, KA | 1 |
| Furukawa, N; Ohta, T; Wakitani, K; Yonemori, F | 1 |
| Bataille, D; Blache, P; Gros, L; Salazar, G; Virsolvy, A | 1 |
| Anello, M; Henquin, JC; Sato, Y | 1 |
| Barg, S; Berggren, PO; Bertorello, A; Bokvist, K; Braun, M; Eliasson, L; Holmes, WE; Köhler, M; Renström, E; Rorsman, P; Thévenod, F | 1 |
| Golanov, EV; Reis, DJ | 1 |
| Jones, RB; Simpson, AE | 1 |
| Ashcroft, FM; Ashcroft, SJ; Ashfield, R; Gribble, FM | 1 |
| Brismar, T; Hyllienmark, L | 1 |
| Carpenter, E; Peers, C; Roberts, ML; Taylor, SC | 1 |
| Anello, M; Gilon, P; Henquin, JC | 1 |
| Nadal, A; Quesada, I; Soria, B | 1 |
| Aguilar-Bryan, L; Bryan, J | 1 |
| Dallaporta, M; Orsini, JC; Perrin, J | 1 |
| Bernardi, G; Giacomini, P; Marinelli, S; Mercuri, NB | 1 |
| Brioni, JD; Gopalakrishnan, M; Molinari, EJ; Monteggia, LM; Roch, JM; Scott, VE; Shieh, CC; Sullivan, JP; Whiteaker, KL | 1 |
| Callingham, BA; Crosbie, AE; Latimer, RD; Ritchie, AJ; Vuylsteke, A | 1 |
| Bloom, SR; Ghatei, MA; Kulkarni, RN; Smith, DM; Wang, RM; Wang, ZL | 1 |
| Galli Kienle, M; Magni, F; Marazzini, L; Monti, L; Pereira, S | 1 |
| Ashford, ML; Campbell, CM; Kinsella, JM; McKay, NG | 1 |
| Mohan, RM; Paterson, DJ | 1 |
| de Smet, PA; Fischer, HR | 1 |
| Dijkman, HB; Engbersen, R; Kramers, C; Moons, MM; Russel, FG; Smits, P; Wouterse, AC | 1 |
| Almond, SC; Paterson, DJ | 1 |
| Carlen, PL; Pahapill, PA; Pelletier, MR; Pennefather, PS | 1 |
| Ball, AJ; Flatt, PR; McClenaghan, NH | 1 |
| Kang, YY; Kim, JA; Lee, YS | 1 |
| Bae, YH; Kim, SW; Park, KH | 1 |
| Bielfeld-Ackermann, A; Konstas, AA; Korbmacher, C | 1 |
| Duarte, ID; Soares, AC | 1 |
| Gonoi, T; Ichikawa, K; Kusama, H; Seino, S; Shibasaki, T; Sunaga, Y; Yano, H | 1 |
| Bisaccia, F; Gasbarro, AR; Lograno, MD; Ostuni, A; Tamburro, AM | 1 |
| Castañeda-Hernández, G; Granados-Soto, V; Ortiz, MI; Rosas, R; Torres-López, JE; Vidal-Cantú, GC | 2 |
| Alves, D; Duarte, I | 1 |
| Ashcroft, SJ; Mikhailov, MV; Mikhailova, EA | 1 |
| Clapp, LH; Wilson, AJ | 1 |
| Argüelles, CF; Granados-Soto, V; Ortiz, MI | 1 |
| Giblin, JP; Quinn, K; Tinker, A | 1 |
| Castañeda-Hernández, G; Granados-Soto, V; Ortiz, MI | 2 |
| Brockmöller, J; Gerloff, T; Kirchheiner, J; Meisel, C; Mrozikiewicz, PM; Niewinski, P; Roots, I | 1 |
| Dugravot, S; Grolleau, F; Hue, B; Huignard, J; Lapied, B; Macherel, D; Rochetaing, A; Stankiewicz, M | 1 |
| Chen, M; Dong, Y; Simard, JM | 1 |
| Berggren, PO; Corkey, BE; Hamilton, JA; Kamp, F; Kizilbash, N | 1 |
| Alves, DP; Duarte, ID; Leite, R; Tatsuo, MA | 1 |
| Ball, AJ; Flatt, PR; McClenaghan, NH; McCluskey, JT | 1 |
| Alves, DP; Amarante, LH; Duarte, ID | 1 |
| Bae, JH; Cho, CH; Han, J; Jang, BC; Kim, SP; Kim, SS; Lee, HY; Lim, JG; Park, JW; Park, MJ; Song, DK; Suh, SI; Yun, JE | 1 |
| Borelli, F; Costa, ZS; Jacobsen, M; Jacobus, AP; Loss, ES; Wassermann, GF | 1 |
| Dao, C; Koster, JC; Nichols, CG; Remedi, MS | 1 |
| Avshalumov, MV; Bao, L; Rice, ME | 1 |
| Han, ES; Kim, YJ; Ko, HH; Lee, CS | 1 |
| Acevedo, JJ; Darszon, A; de la Vega-Beltrán, JL; Felix, R; Mendoza-Lujambio, I; Treviño, CL | 1 |
| Castañeda-Hernández, G; Castro-Olguín, J; Ortiz, MI; Peña-Samaniego, N | 1 |
| Conte Camerino, D; Desai, RR; George, AL; Lundquist, AL; Mele, A; Tricarico, D | 1 |
| Granados-Soto, V; Medina-Tato, DA; Ortiz, MI; Palma-Martínez, J; Sarmiento-Heredia, D | 1 |
| Ashcroft, FM; Clark, PM; Codner, E; Ellard, S; Flanagan, SE; Flechtner, I; Hattersley, AT; Holst, JJ; Iotova, V; Klimes, I; Larkin, B; Malecki, MT; Njølstad, PR; Pearson, ER; Polak, M; Robert, JJ; Shield, J; Slingerland, AS; Søvik, O | 1 |
| Kaku, K; Katsura, M; Matsuda, M; Ohkuma, S; Shigeto, M | 1 |
| Brito, GA; Cunha, FQ; Ferreira, SH; Lotufo, CM; Ribeiro, RA; Sachs, D; Vale, ML | 1 |
| Duarte, ID; Reis, GM | 1 |
| Brennan, L; Flatt, PR; Hewage, C; Malthouse, JP; McClenaghan, NH; Newsholme, P | 1 |
| Coetzee, WA; Ghiu, I; Gutstein, DE; Hendricks-Munoz, KD; Kontogeorgis, A; Malester, B; Tong, X; Xu, J | 1 |
| Antunes, CM; Baldeiras, IE; Barbosa, RM; Rosário, LM; Santos, RM; Silva, AM; Tomé, AR | 1 |
| Iwasaki, M; Katoh, M; Miki, T; Minami, K; Seino, S; Shibasaki, T; Sunaga, Y; Takahashi, H; Yokoi, N; Zhang, CL | 1 |
| Chen, SR; Li, DP; Pan, HL | 1 |
| Breschi, MC; Calderone, V; Cecchetti, V; Martelli, A; Sabatini, S; Testai, L | 1 |
| Bailey, CJ; Flatt, PR; Irwin, N; McClenaghan, NH; McKinney, JM | 1 |
| Cheng, X; Gribenko, AV; Tsalkova, T | 1 |
| Andersson, C; Gislason, GH; Hansen, PR; Jørgensen, CH; Køber, L; Mérie, C; Norgaard, ML; Olesen, JB; Schmiegelow, M; Sørensen, R; Torp-Pedersen, C; Vaag, A; Weeke, P | 1 |
| Chung, KK; Freestone, PS; Lipski, J | 1 |
| Abdelmoneim, AS; Brocks, DR; Hasenbank, SE; Light, PE; Seubert, JM; Simpson, SH | 1 |
| Cannone, G; Carbonara, G; Cippone, V; Conte Camerino, D; Fracchiolla, G; Laghezza, A; Loiodice, F; Mele, A; Rolland, JF; Tortorella, P; Tricarico, D | 1 |
| Ishii, I; Itoh, N; Kimura, H; Kimura, T; Kimura, Y; Naito, Y; Niki, I; Taniguchi, S; Umeki, T; Yamamoto, H | 1 |
| Cui, G; McCarty, NA; Song, B; Turki, HW | 1 |
| Fatehi, M; Lang, VY; Light, PE | 1 |
| Ahmadi, A; Khalili, M; Nahri-Niknafs, B; Roudsari, EM; Seyedhoseyni, S | 1 |
| Bond, R; Choisy, SC; El Haou, S; Hancox, JC; James, AF; Khaliulin, I; Kim, SJ; Lin, H; Milnes, JT; Suleiman, MS; Zhang, H | 1 |
| Bo, S; Castiglione, A; Cavallo-Perin, P; Ciccone, G; Durazzo, M; Gentile, L; Ghigo, E | 1 |
| Friščić, T; Mottillo, C; Štrukil, V; Tan, D | 1 |
| Jung, JS; Kim, CH; Kim, SJ; Kim, SS; Lim, SM; Park, SH; Sim, YB; Suh, HW | 1 |
| Andersson, C; Fosbøl, EL; Gislason, G; Køber, L; Mogensen, UM; Scheller, NM; Schramm, TK; Torp-Pedersen, C; Vaag, A | 1 |
| Eliassi, A; Fahanik-Babaei, J; Ghasemi, M; Saghiri, R; Salari, S; Sauve, R | 1 |
| Henquin, JC; Nenquin, M | 1 |
| Brown, J; Crowther, CA; Hughes, B; Martis, R; Rowan, J | 1 |
| Bashir, K; Chang, C; Chen, G; Fu, Q; Ge, Y; Guo, P; Jing, W; Luo, Z; Shu, H; Xu, X | 1 |
| Barella, LF; Chen, W; Cheng, X; Cui, Y; Gurevich, VV; Mei, FC; Rossi, M; Wess, J; Zhu, L | 1 |
| Jannetto, PJ; Langman, LJ | 1 |
19 review(s) available for glyburide and tolbutamide
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
["First" and "second" generation sulfonylureas: distinction or difference? (author's transl)].
Topics: Animals; Chlorpropamide; Dose-Response Relationship, Drug; Glipizide; Glyburide; Half-Life; Humans; Hypoglycemic Agents; Kinetics; Structure-Activity Relationship; Sulfonylurea Compounds; Tolbutamide | 1978 |
[New aspects of therapy with oral antidiabetic agents].
Topics: Acidosis; Biguanides; Blood Proteins; Chlorpropamide; Diabetes Mellitus; Diabetic Nephropathies; Drug Interactions; Glyburide; Humans; Hypoglycemia; Hypoglycemic Agents; Protein Binding; Sulfonamides; Sulfonylurea Compounds; Tolbutamide | 1979 |
Drug interactions with oral sulphonylurea hypoglycaemic drugs.
Topics: Allopurinol; Analgesics; Anticoagulants; Chloramphenicol; Chlorpropamide; Disulfiram; Drug Interactions; Ethanol; Glyburide; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Kinetics; Monoamine Oxidase Inhibitors; Novobiocin; Phenylbutazone; Phenytoin; Probenecid; Propranolol; Rifampin; Sulfonamides; Sulfonylurea Compounds; Tolbutamide | 1977 |
Oral treatment in diabetes.
Topics: Acetohexamide; Acidosis; Administration, Oral; Animals; Biguanides; Cardiovascular Diseases; Chlorpropamide; Diabetes Complications; Diabetes Mellitus; Glyburide; Humans; Hypoglycemia; Liver; Obesity; Structure-Activity Relationship; Sulfonylurea Compounds; Tolazamide; Tolbutamide | 1972 |
[Central role of the pancreas in the mechanism of action of hypoglycemic sulfonamides and their consequences in the therapy and prevention of diabetes].
Topics: Animals; Diabetes Mellitus; Glyburide; Growth; Growth Hormone; Humans; Hypoglycemic Agents; Pancreas; Rats; Sulfonamides; Tolbutamide | 1970 |
Glibenclamide, a new sulphonylurea: whither oral hypoglycaemic agents?
Topics: Administration, Oral; Adolescent; Adult; Blood Glucose; Carbohydrates; Child; Coronary Disease; Diabetes Complications; Diabetes Mellitus; Diet, Diabetic; Fatty Acids; Glyburide; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Sulfonylurea Compounds; Tolbutamide | 1971 |
The pharmacology and metabolism of oral antidiabetic drugs.
Topics: Administration, Oral; Adrenal Glands; Animals; Blood Glucose; Chemical Phenomena; Chemistry; Dogs; Glyburide; Guinea Pigs; Humans; Hypoglycemic Agents; In Vitro Techniques; Insulin; Islets of Langerhans; Mice; Rabbits; Rats; Semicarbazides; Sulfonamides; Sulfonylurea Compounds; Tolbutamide | 1971 |
Interaction of sulfonylurea with the pancreatic B-cell.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Adenosine Triphosphate; Amino Acids; Animals; Calcimycin; Calcium; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Fatty Acids; Glucose; Glyburide; Humans; Islets of Langerhans; Lasalocid; Membrane Potentials; NADP; Phenylbutazone; Rubidium; Serum Albumin; Sulfonylurea Compounds; Time Factors; Tolbutamide | 1984 |
[25 years of diabetic treatment by oral hypoglycemic agents: successes and failures].
Topics: Aged; Aging; Blood Glucose; Cardiovascular Diseases; Chlorpropamide; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Type 2; Diet, Reducing; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Middle Aged; Phenformin; Sulfonylurea Compounds; Tolbutamide | 1984 |
[Potential role of ATP-sensitive K+ channels in ischemia- and reperfusion-induced arrhythmias].
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; Glyburide; Guanidines; Humans; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Niacinamide; Nicorandil; Pinacidil; Potassium; Potassium Channels; Pyrroles; Tolbutamide | 1993 |
Cardiovascular effects of sulphonylurea derivatives.
Topics: Adenosine Triphosphate; Animals; Cardiovascular System; Diabetes Mellitus, Type 2; Glyburide; Humans; Hypoglycemic Agents; Potassium Channels; Sulfonylurea Compounds; Tolbutamide | 1996 |
Cardiovascular effects of oral hypoglycaemic drugs.
Topics: Biguanides; Diabetes Mellitus, Type 2; Glyburide; Heart; Hemodynamics; Humans; Hypoglycemic Agents; Lipoproteins; Metformin; Myocardial Contraction; Potassium Channel Blockers; Stimulation, Chemical; Sulfonylurea Compounds; Tolbutamide | 1996 |
Anti-diabetic drugs as a cause of hypoglycaemia among acute medical admissions in Hong Kong and Singapore--relationship to the prescribing patterns in diabetic patients.
Topics: Acute Disease; Age Factors; Aged; China; Diabetes Mellitus; Drug Prescriptions; Drug Utilization; Glyburide; Hong Kong; Humans; Hypoglycemia; Hypoglycemic Agents; Middle Aged; Patient Admission; Practice Patterns, Physicians'; Prevalence; Risk Factors; Singapore; Tolbutamide | 1998 |
Sulfonylurea receptors: ABC transporters that regulate ATP-sensitive K(+) channels.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; ATP-Binding Cassette Transporters; Benzamides; Cell Line; Cytoplasm; Electrochemistry; Endoplasmic Reticulum; Glyburide; Humans; Magnesium; Models, Molecular; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide | 1999 |
[Timing of administration of sulfonyl urea derivatives].
Topics: Biological Availability; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Administration Schedule; Gliclazide; Glipizide; Glyburide; Humans; Hypoglycemic Agents; Tolbutamide | 2000 |
Implications of pharmacogenetics for individualizing drug treatment and for study design.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Clinical Trials as Topic; Cytochrome P-450 Enzyme System; Genotype; Glyburide; Humans; Hypoglycemic Agents; Pharmaceutical Preparations; Pharmacogenetics; Tolbutamide | 2003 |
Variations in tissue selectivity amongst insulin secretagogues: a systematic review.
Topics: Animals; ATP-Binding Cassette Transporters; Carbamates; Cardiovascular Diseases; Cricetinae; Cyclohexanes; Diabetes Mellitus, Type 2; Gliclazide; Glipizide; Glyburide; Humans; Hypoglycemic Agents; Ischemic Preconditioning, Myocardial; Isoindoles; Mice; Muscle, Smooth, Vascular; Myocytes, Cardiac; Nateglinide; Phenylalanine; Piperidines; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Risk Factors; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide | 2012 |
Oral anti-diabetic pharmacological therapies for the treatment of women with gestational diabetes.
Topics: Acarbose; Administration, Oral; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemia; Hypoglycemic Agents; Metformin; Pregnancy; Randomized Controlled Trials as Topic; Tolbutamide | 2017 |
18 trial(s) available for glyburide and tolbutamide
| Article | Year |
|---|---|
[Clinical investigations of the effect of tolbutamide and glibenclamide on pancreatic glucagon secretion (author's transl)].
Topics: Adult; Arginine; Blood Glucose; Glucagon; Glyburide; Humans; Insulin; Male; Pancreas; Tolbutamide | 1975 |
[Therapeutic effect of glibenclamide contrasted with other oral antidiabetic agents].
Topics: Administration, Oral; Adult; Biguanides; Chlorpropamide; Chronic Disease; Clinical Trials as Topic; Diabetes Mellitus; Drug Evaluation; Drug Therapy, Combination; Female; Glyburide; Humans; Hypoglycemic Agents; Male; Middle Aged; Tolbutamide | 1975 |
Efficacy of gliclazide in comparison with other sulphonylureas in the treatment of NIDDM.
Topics: Blood Glucose; Chlorpropamide; Diabetes Mellitus, Type 2; Diet, Diabetic; Gliclazide; Glipizide; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Tolbutamide | 1991 |
A randomized crossover study of sulphonylurea and insulin treatment in patients with type 2 diabetes poorly controlled on dietary therapy.
Topics: Blood Glucose; C-Peptide; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Diet, Diabetic; Fasting; Female; Glyburide; Glycated Hemoglobin; Humans; Insulin; Islets of Langerhans; Male; Middle Aged; Random Allocation; Tolbutamide | 1989 |
[The influence of various sulphonylurea derivatives on the oral glucose-tolerance tests in healthy subjects and obese and maturity-onset diabetics (author's transl)].
Topics: Administration, Oral; Adult; Blood Glucose; Diabetes Mellitus; Glucose; Glucose Tolerance Test; Glyburide; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Obesity; Statistics as Topic; Stimulation, Chemical; Sulfonylurea Compounds; Time Factors; Tolbutamide | 1974 |
Dose-response relationships of tolbutamide and glibenclamide in diabetes mellitus.
Topics: Adult; Aged; Blood Glucose; Clinical Trials as Topic; Colorimetry; Diabetes Mellitus; Dose-Response Relationship, Drug; Female; Glyburide; Humans; Injections; Insulin; Male; Middle Aged; Obesity; Radioimmunoassay; Time Factors; Tolbutamide | 1974 |
[Blood sugar, serum insulin, nonesterified fatty acids and somatotropin in daily profile in adult diabetics under monotherapy with various sulfonylureas].
Topics: Blood Glucose; Body Weight; Diabetes Mellitus; Diet, Diabetic; Fatty Acids, Nonesterified; Glyburide; Glycosuria; Growth Hormone; Humans; Insulin; Middle Aged; Sulfonylurea Compounds; Tolbutamide | 1974 |
The effect of oral sulphonylureas on blood glucose and insulin.
Topics: Administration, Oral; Adult; Blood Glucose; Body Height; Body Weight; Clinical Trials as Topic; Female; Glyburide; Humans; Insulin; Male; Placebos; Sulfonylurea Compounds; Tolbutamide | 1973 |
Controlled extension of oral antidiabetic therapy on former insulin dependent diabetics by means of the combined i.v. glibenclamide-glucose-response-test.
Topics: Administration, Oral; Adult; Age Factors; Aged; Clinical Trials as Topic; Diabetes Mellitus; Drug Combinations; Drug Resistance; Female; Glucose; Glyburide; Hemochromatosis; Humans; Hypoglycemic Agents; Injections, Intravenous; Insulin; Insulin Antibodies; Male; Methods; Middle Aged; Prognosis; Sulfonylurea Compounds; Tolbutamide | 1972 |
[Clinical testing of a sulphonylurea derivative, glibornuride].
Topics: Adult; Aged; Biguanides; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus; Diet Therapy; Female; Glyburide; Glycosuria; Humans; Male; Middle Aged; Sulfonylurea Compounds; Tolbutamide | 1972 |
A clinical evaluation of glibenclamide (HB 419, "Daonil") a new antidiabetic sulphonylurea.
Topics: Administration, Oral; Adolescent; Adult; Aged; Alcohol Drinking; Clinical Trials as Topic; Diabetes Mellitus; Female; Glucose Tolerance Test; Glyburide; Humans; Hypoglycemia; Insulin; Male; Middle Aged; Pyrimidines; Sulfonylurea Compounds; Tolbutamide | 1972 |
Oral substitutes for insulin: modern appraisal of their action and indications.
Topics: Adolescent; Adult; Aged; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diet, Diabetic; Dogs; Glucose Tolerance Test; Glyburide; Humans; Hypoglycemic Agents; Insulin; Middle Aged; Phenformin; Placebos; Rats; Sulfonamides; Tolbutamide | 1972 |
[Therapy of diabetes in adults using Glibornurid. Results and clinical studies].
Topics: Aged; Blood Glucose; Body Weight; Camphanes; Clinical Trials as Topic; Diabetes Mellitus; Drug Hypersensitivity; Female; Glyburide; Glycosuria; Humans; Hypoglycemic Agents; Male; Middle Aged; Sulfonylurea Compounds; Tolbutamide | 1973 |
[Clinical testing of a sulfonylurea preparation (glibenclamide)].
Topics: Adult; Aged; Chlorpropamide; Clinical Trials as Topic; Diabetes Mellitus; Diet Therapy; Female; Glyburide; Humans; Hypoglycemic Agents; Male; Middle Aged; Tolbutamide | 1969 |
The clinical evaluation of an oral antidiabetic drug.
Topics: Administration, Oral; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus; Glyburide; Humans; Insulin; Lipids; Sulfonylurea Compounds; Tolbutamide | 1971 |
Lack of interaction between fluvastatin and oral hypoglycemic agents in healthy subjects and in patients with non-insulin-dependent diabetes mellitus.
Topics: Administration, Oral; Anticholesteremic Agents; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Diclofenac; Drug Interactions; Fatty Acids, Monounsaturated; Fluvastatin; Glyburide; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Insulin; Lovastatin; Placebos; Simvastatin; Tolbutamide | 1995 |
Effects of a new oral hypoglycaemic agent, repaglinide, on metabolic control in sulphonylurea-treated patients with NIDDM.
Topics: Aged; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Female; Fructosamine; Gliclazide; Glyburide; Glycated Hemoglobin; Hexosamines; Humans; Hypoglycemic Agents; Lipids; Male; Middle Aged; Piperidines; Tolbutamide | 1993 |
An importance of carbohydrate ingestion for the expression of the effect of alpha-glucosidase inhibitor in NIDDM.
Topics: Biomarkers; Blood Glucose; C-Peptide; Circadian Rhythm; Diabetes Mellitus, Type 2; Dietary Carbohydrates; Energy Intake; Enzyme Inhibitors; Follow-Up Studies; Glyburide; Glycated Hemoglobin; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Inpatients; Insulin; Middle Aged; Regression Analysis; Retrospective Studies; Sulfonylurea Compounds; Tolbutamide | 1996 |
379 other study(ies) available for glyburide and tolbutamide
| Article | Year |
|---|---|
Sulfonyliminoimidazolidines. A new class of oral hypoglycemic agents. 1. 1-[[p-[2-(acylamino)ethyl]phenyl]sulfonyl]-2-iminoimidazolidines.
Topics: Animals; Biological Assay; Blood Glucose; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Imidazoles; Indicators and Reagents; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Sulfones | 1983 |
Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; ATP-Binding Cassette Transporters; Base Sequence; Cell Line; Chromosome Mapping; Chromosomes, Human, Pair 11; Cloning, Molecular; Cricetinae; Diazoxide; Humans; Islets of Langerhans; KATP Channels; Mice; Molecular Sequence Data; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Rubidium; Sulfonylurea Compounds; Sulfonylurea Receptors | 1995 |
A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; ATP-Binding Cassette Transporters; Base Sequence; Cell Line; Cloning, Molecular; DNA, Complementary; Humans; Mice; Molecular Sequence Data; Muscle, Smooth; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Sulfonylurea Receptors | 1996 |
Inhibitory effect of anti-diabetic agents on rat organic anion transporter rOAT1.
Topics: Animals; Anion Transport Proteins; Binding, Competitive; Carbon Radioisotopes; Carrier Proteins; Chlorpropamide; Cyclohexanes; Dose-Response Relationship, Drug; Female; Glyburide; Hypoglycemic Agents; Kinetics; Nateglinide; Oocytes; p-Aminohippuric Acid; Phenylalanine; Rats; RNA, Complementary; Sulfonylurea Compounds; Tolbutamide; Xenopus | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport.
Topics: Algorithms; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibiotics, Antitubercular; Antimalarials; Biological Transport, Active; Digoxin; Enzyme Inhibitors; Estradiol; Ibuprofen; LLC-PK1 Cells; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Quinidine; Quinine; Rats; Rifampin; Swine | 2002 |
Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B.
Topics: Beverages; Cell Line; Citrus paradisi; Citrus sinensis; Estrone; Glyburide; Humans; Organic Anion Transporters; Transfection | 2005 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Hologram QSAR model for the prediction of human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions.
Topics: Binding Sites; Crystallography, X-Ray; Drug Interactions; Humans; Pharmaceutical Preparations; Protein Binding; Protein Structure, Tertiary; Serum Albumin; Spectrometry, Fluorescence | 2010 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors | 2012 |
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Identification of the first in silico-designed TREK1 antagonists that block channel currents dose dependently.
Topics: Animals; Computer Simulation; Crystallography, X-Ray; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Mice; Mice, Knockout; Molecular Docking Simulation; Potassium Channels, Tandem Pore Domain | 2016 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
High-performance liquid chromatographic determination of glipizide and some other sulfonylurea drugs in serum.
Topics: Chlorpropamide; Chromatography, High Pressure Liquid; Glipizide; Glyburide; Humans; Hydrogen-Ion Concentration; Sulfonylurea Compounds; Tolbutamide | 1979 |
Effects of chronic and acute treatment with sulfonylureas on plasma insulin and glucose levels in the rat.
Topics: Acetoacetates; Animals; Blood Glucose; Fasting; Female; Glyburide; Hydroxybutyrates; Insulin; Kinetics; Rats; Sulfonylurea Compounds; Tolbutamide | 1978 |
Glycogen phosphorylase activities in sulfonylureas treated rats.
Topics: Animals; Female; Glyburide; Liver; Muscles; Phosphorylases; Rats; Sulfonylurea Compounds; Tolbutamide | 1978 |
Studies on the effect of tolbutamide, glibenclamide, HB 699, and glucose on serum insulin and blood glucose in gastro-enterectomized dogs.
Topics: Animals; Blood Glucose; Digestive System Physiological Phenomena; Dogs; Female; Glucose; Glyburide; Hypoglycemic Agents; Insulin; Male; Pancreas; Regional Blood Flow; Sulfonylurea Compounds; Time Factors; Tolbutamide; Vagotomy | 1978 |
Changes in plasma amino acids levels and "in vivo" gluconeogenesis from alanine in rats chronically treated with sulfonylureas.
Topics: Alanine; Amino Acids; Animals; Blood Glucose; Female; Gluconeogenesis; Glyburide; Glycerides; Glycerol; Hypoglycemic Agents; Liver; Liver Glycogen; Rats; Sulfonylurea Compounds; Tolbutamide | 1978 |
Effect of sulfonylurea treatment and fasting on the levels of plasma amino acids in the rat.
Topics: Amino Acids; Animals; Fasting; Female; Glyburide; Hydroxyproline; Proline; Rats; Sulfonylurea Compounds; Tolbutamide | 1978 |
Gas chromatographic determination of glibenclamide in plasma.
Topics: Administration, Oral; Chromatography, Gas; Glyburide; Humans; Microchemistry; Tolbutamide | 1979 |
Insulin release by tolbutamide and glibenclamide. A comparative study on the perfused rat pancreas.
Topics: Animals; Glucose; Glyburide; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Pancreas; Rats; Time Factors; Tolbutamide | 1979 |
Release of gastrin from the skeletal muscles and from the antral mucosa in cats induced by sulfonuric drugs.
Topics: Animals; Cats; Gastric Mucosa; Gastrins; Glyburide; Hindlimb; Muscles; Perfusion; Pyloric Antrum; Secretory Rate; Tolbutamide | 1979 |
[Comparative use of gliquidone and tolbutamide administered intravenously].
Topics: Basal Metabolism; Blood Glucose; Fasting; Fatty Acids, Nonesterified; Glyburide; Humans; Injections, Intravenous; Insulin; Insulin Secretion; Sulfonylurea Compounds; Time Factors; Tolbutamide | 1975 |
Dynamics of sulfonylurea-induced insulin release from the isolated perfused rat pancreas.
Topics: Animals; Glipizide; Glyburide; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Perfusion; Rats; Sulfonylurea Compounds; Tolbutamide | 1976 |
Hyaluronidase-induced inhibition of the insulinotropic action of sulfonylureas, leucine, and glucagon in rodent isolated pancreatic islets.
Topics: Animals; Chlorpropamide; Cricetinae; Female; Glucagon; Glucose; Glyburide; Hyaluronoglucosaminidase; Insulin; Islets of Langerhans; Leucine; Mice; Microbial Collagenase; Rats; Species Specificity; Sulfonylurea Compounds; Tolbutamide | 1976 |
[The role of cyclic AMP in the control of insulin secretion (author's transl)].
Topics: Animals; Cyclic AMP; Dose-Response Relationship, Drug; Drug Synergism; Glucose; Glyburide; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Mannose; Phosphodiesterase Inhibitors; Rats; Receptors, Drug; Time Factors; Tolbutamide; Xanthines | 1977 |
Inhibition of vasopressin-stimulated prostaglandin E biosynthesis by chlorpropamide in the toad urinary bladder. Mechanism of enhancement of vasopressin-stimulated water flow.
Topics: Animals; Anura; Arginine Vasopressin; Chlorpropamide; Chromatography, Thin Layer; Cyclic AMP; Glyburide; Lipid Metabolism; Permeability; Prostaglandins E; Stimulation, Chemical; Structure-Activity Relationship; Theophylline; Tolbutamide; Urinary Bladder; Vasopressins; Water | 1977 |
The positive inotropic action of sulfonylureas. A mechanism independent of cyclic adenosine 3',5'-monophosphate.
Topics: Adenylyl Cyclases; Animals; Atrial Function; Cyclic AMP; Dose-Response Relationship, Drug; Glyburide; Guinea Pigs; Heart; Isoproterenol; Male; Myocardial Contraction; Myocardium; Rabbits; Rats; Species Specificity; Tolbutamide; Ventricular Function | 1978 |
Cyclic AMP and insulin release.
Topics: Animals; Cricetinae; Cyclic AMP; Glucose; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Tolbutamide | 1977 |
Modification of diuresis in the rat by chlorpropamide, glibenclamide and tolbutamide.
Topics: Administration, Oral; Animals; Body Water; Chlorpropamide; Diabetes Mellitus; Diuresis; Glyburide; Hydrogen-Ion Concentration; Male; Potassium; Rats; Sodium; Streptozocin; Time Factors; Tolbutamide | 1975 |
Side effects of therapy in diabetes evaluated by a self-administered questionnaire.
Topics: Chlorpropamide; Diabetes Mellitus; Diet, Diabetic; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Patient Acceptance of Health Care; Phenformin; Surveys and Questionnaires; Tolbutamide | 1977 |
The pharmacology of a new hypoglycaemic agent N-[4-(2-(2,3-dihydrobenzo(b)furan-m-carboxamido)-ethyl)-benzenesulphonyl]-N'-cyclohexylurea (NOVO CS 476). I. Pharmacological studies on the hypoglycaemic effect.
Topics: Administration, Oral; Animals; Blood Glucose; Dogs; Drug Evaluation, Preclinical; Glucose Tolerance Test; Glyburide; Hypoglycemic Agents; Injections, Intravenous; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Inbred Strains; Rabbits; Rats; Rats, Inbred Strains; Sulfonylurea Compounds; Tolbutamide | 1977 |
The pharmacology of a new hypoglycaemic agent N-[4-(2-(2,3-dihydrobenzo(b)furan-7-carboxamid o)-ethyl)-benzenesulphonyl]-N'-cyclohexlurea (NOVO CS 476). III. General pharmacological studies.
Topics: Animals; Blood Pressure; Cats; Chlorpropamide; Diuresis; Dogs; Female; Glyburide; Guinea Pigs; Heart; Hypoglycemic Agents; Male; Muscle Contraction; Muscle, Smooth; Papillary Muscles; Rats; Sulfonylurea Compounds; Tolbutamide | 1977 |
[Clinico-statistical studies of the use of oral hypoglycemic agents in the therapy of diabetes: critical evaluation of their effectiveness and tolerance].
Topics: Adult; Aged; Chlorpropamide; Diabetes Mellitus; Drug Evaluation; Drug Therapy, Combination; Female; Glyburide; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Phenformin; Tolbutamide | 1977 |
[Hypoglycemic sulfonylurea metabolites: clinical interest. Experiences with glibenclamide in the rat].
Topics: Animals; Biotransformation; Blood Glucose; Chlorpropamide; Glyburide; Injections, Intraperitoneal; Rats; Tolbutamide | 1977 |
Long-term actions of sulfonylureas on (pro-) insulin biosynthesis and secretion: I. Lack of evidence for a compensatory increase in (pro-) insulin biosynthesis after exposure of isolated pancreatic rat islets to tolbutamide and glibenclamide in vitro.
Topics: Animals; Glucose; Glyburide; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Proinsulin; Rats; Time Factors; Tolbutamide | 1977 |
[Insulin and pro-insulin secretion following intravenous administration of tolbutamide, glisoxepide and glibenclamide].
Topics: Blood Glucose; Glyburide; Humans; Insulin; Insulin Secretion; Proinsulin; Sulfonylurea Compounds; Time Factors; Tolbutamide | 1978 |
Long-term actions of sulfonylureas on (pro-)insulin biosynthesis and secretion. II. Studies after administration of tolbutamide and glibenclamide to rats in vivo.
Topics: Animals; Body Weight; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Male; Proinsulin; Rats; Time Factors; Tolbutamide | 1978 |
Sulfonylurea-induced factitious hypoglycemia in a nondiabetic nurse.
Topics: Adult; Blood Glucose; Female; Glucose Tolerance Test; Glyburide; Humans; Hypoglycemia; Insulin; Munchausen Syndrome; Sulfonylurea Compounds; Tolbutamide | 1975 |
[Experimental studies on the mechanism of thrombocyte aggregation inhibition caused by sulfonylurea compounds. 2. Modification of blood sugar and thrombocyte aggregation by oral antidiabetics].
Topics: Adenosine Monophosphate; Administration, Oral; Animals; Biguanides; Blood Glucose; Carbutamide; Depression, Chemical; Dose-Response Relationship, Drug; Glyburide; Hypoglycemic Agents; Injections, Intravenous; Platelet Adhesiveness; Platelet Aggregation; Pyrimidines; Rats; Semicarbazides; Sulfonylurea Compounds; Tolazamide; Tolbutamide | 1975 |
[Effect of methylpyrazole-carboxylic acid on carbohydrate and lipid metabolisms in patients with diabetes mellitus].
Topics: Aged; Blood Glucose; Carbutamide; Cholesterol; Diabetes Mellitus; Drug Evaluation; Fatty Acids, Nonesterified; Female; Glyburide; Glycosuria; Humans; Hypoglycemic Agents; Male; Middle Aged; Pyrazoles; Stimulation, Chemical; Tolbutamide; Triglycerides | 1975 |
Myocardial infarction in diabetics.
Topics: Administration, Oral; Adult; Aged; Chlorpropamide; Coronary Care Units; Diabetes Complications; Diabetes Mellitus; Diabetic Retinopathy; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Myocardial Infarction; Phenformin; Sex Factors; Sulfonylurea Compounds; Tolbutamide | 1975 |
Gliflumide, a new oral antidiabetic of high potency and efficacy.
Topics: Administration, Oral; Animals; Blood Glucose; Cricetinae; Dogs; Fatty Acids, Nonesterified; Glucose; Glyburide; Humans; Hypoglycemic Agents; Injections, Intravenous; Insulin; Insulin Secretion; Kinetics; Pyrimidines; Rats; Stereoisomerism; Sulfonamides; Theophylline; Tolbutamide | 1975 |
[Studies on new sulfonylurea derivatives and their metabolites in isolated Langerhans's islets of the rat pancreas (author's transl].
Topics: Animals; Glyburide; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Stimulation, Chemical; Sulfonylurea Compounds; Time Factors; Tolbutamide | 1975 |
[The importance of serum insulin determination in the diagnosis and treatment of diabetes mellitus (author's transl)].
Topics: Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diet Therapy; Dose-Response Relationship, Drug; Glucose Tolerance Test; Glyburide; Humans; Insulin; Obesity; Prediabetic State; Prognosis; Radioimmunoassay; Sulfonylurea Compounds; Tolbutamide | 1975 |
(Pro-) insulin biosynthesis and release of newly synthesized (pro-) insulin from isolated islets of rat pancreas in the presence of amino acids and sulphonylureas.
Topics: Amino Acids; Animals; Arginine; Glyburide; In Vitro Techniques; Insulin; Islets of Langerhans; Lysine; Male; Proinsulin; Rats; Sulfonylurea Compounds; Tolbutamide | 1975 |
[Relation of uric acid and arteriosclerosis on an experimental model of chickens fed with eggs. Influence of insulin and oral antidiabetics (glibenclamide and tolbutamide)].
Topics: Animals; Arteriosclerosis; Chickens; Cholesterol, Dietary; Disease Models, Animal; Eggs; Glyburide; Insulin; Sex Factors; Tolbutamide; Uric Acid | 1975 |
[Effect of tolbutamide and glibenclamide on glucagon secretion in subjects with normal metabolism and in diabetics].
Topics: Adult; Diabetes Mellitus; Glucagon; Glyburide; Humans; Male; Tolbutamide | 1975 |
Circular dichroism studies on the interaction of sulfonylureas with bovine and human serum albumin.
Topics: Binding Sites; Binding, Competitive; Carbutamide; Chlorpropamide; Circular Dichroism; Glipizide; Glyburide; Humans; In Vitro Techniques; Optical Rotatory Dispersion; Protein Binding; Serum Albumin; Serum Albumin, Bovine; Sulfonylurea Compounds; Tolbutamide | 1976 |
Displacement of tolbutamide, glibencalmide and chlorpropamide from serum albumin by anionic drugs.
Topics: Acetaminophen; Animals; Cattle; Chlorpropamide; Dialysis; Glyburide; Humans; Phenylbutazone; Protein Binding; Salicylates; Serum Albumin; Serum Albumin, Bovine; Sulfaphenazole; Tolbutamide; Warfarin | 1976 |
[Experimental study of glipizide. A comparison with other hypoglycemic sulfonamides (author's transl)].
Topics: Administration, Oral; Ammonia; Animals; Dogs; Dose-Response Relationship, Drug; Female; Glipizide; Glyburide; Injections, Intravenous; Insulin; Islets of Langerhans; Mice; Purine-Pyrimidine Metabolism, Inborn Errors; Rats; Seizures; Sulfonylurea Compounds; Time Factors; Tolbutamide | 1975 |
[Non-saturable cooperative binding of tolbutamide to rat endocrine pancreas. Criteria of specificity].
Topics: Animals; Diazoxide; Drug Interactions; Glipizide; Glucose; Glyburide; Islets of Langerhans; Kinetics; Rats; Tolbutamide | 1976 |
[The insulin-secreting and proliferative activity of established islet cells in the presence of sulfonylurea].
Topics: Animals; Cell Division; Cell Line; Cell Line, Transformed; Cells, Cultured; Cricetinae; Gliclazide; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Rats; Sulfonylurea Compounds; Time Factors; Tolbutamide | 1992 |
Therapeutical concentrations of tolbutamide, glibenclamide, gliclazide and gliquidone at different glucose levels: in vitro effects on pancreatic A- and B-cell function.
Topics: Animals; Blood Glucose; Dose-Response Relationship, Drug; Gliclazide; Glucagon; Glucose; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Perfusion; Rats; Rats, Sprague-Dawley; Sulfonylurea Compounds; Time Factors; Tolbutamide | 1992 |
Influence of KATP channel modulation on net potassium efflux from ischaemic mammalian cardiac tissue.
Topics: Action Potentials; Animals; Barium; Benzopyrans; Cromakalim; Glyburide; Guinea Pigs; Hydrogen-Ion Concentration; Muscles; Myocardial Ischemia; Oxygen; Papillary Muscles; Potassium; Potassium Channels; Pyrroles; Tolbutamide; Vasodilator Agents | 1992 |
Pharmacological evidence for a role of ATP-dependent potassium channels in myocardial stunning.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Dogs; Female; Glyburide; Hemodynamics; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Picolines; Potassium Channels; Pyrans; Risk Factors; Tolbutamide | 1992 |
Effect of tolbutamide and glyburide on pyruvate kinase flux in isolated rat hepatocytes.
Topics: Animals; Bicarbonates; Carbon Radioisotopes; Glucose; Glyburide; Lactates; Liver; Male; Pyruvate Kinase; Rats; Rats, Inbred Strains; Sensitivity and Specificity; Sodium; Sodium Bicarbonate; Sulfonylurea Compounds; Time Factors; Tolbutamide | 1992 |
Opposing actions of tolbutamide and glibenclamide on hypoxic pulmonary vasoconstriction.
Topics: Animals; Benzopyrans; Cromakalim; Diazoxide; Glyburide; Hypoxia; In Vitro Techniques; Lung; Male; Potassium Channels; Pyrroles; Rats; Tolbutamide; Vasoconstriction | 1992 |
Glyburide and tolbutamide induce desensitization of insulin release in rat pancreatic islets by different mechanisms.
Topics: Animals; Calcium; Glucose; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Rats, Wistar; Rubidium; Tolbutamide | 1992 |
Lack of evidence for coupling of the dopamine D2 receptor to an adenosine triphosphate-sensitive potassium (ATP-K+) channel in dopaminergic neurones of the rat substantia nigra.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dopamine; Electrophysiology; Glyburide; Male; Neurons; Potassium Channels; Pyrroles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Dopamine D2; Substantia Nigra; Tolbutamide | 1992 |
High external Ca2+ levels trigger membrane potential oscillations in mouse pancreatic beta-cells during blockade of K(ATP) channels.
Topics: Adenosine Triphosphate; Animals; Calcium; Cell Membrane; Drug Synergism; Fluorescent Dyes; Fura-2; Glyburide; Ionomycin; Islets of Langerhans; Membrane Potentials; Mice; Potassium Channels; Tolbutamide | 1992 |
Inhibition of ATP-sensitive K+ channels in cardiac muscle by the sulphonylurea drug glibenclamide.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Dihydropyridines; Glyburide; Guinea Pigs; Heart Ventricles; Muscle, Smooth, Vascular; Potassium Channels; Tolbutamide; Vasodilator Agents | 1992 |
Role of ATP-sensitive K+ channels during anoxia: major differences between rat (newborn and adult) and turtle neurons.
Topics: Animals; Brain Stem; Dose-Response Relationship, Drug; Glyburide; Homeostasis; Membrane Potentials; Oxygen; Potassium; Potassium Channels; Rats; Tolbutamide; Turtles | 1992 |
Effects of pH upon the inhibition by sulphonylurea drugs of ATP-sensitive K+ channels in cardiac muscle.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Dihydropyridines; Drug Interactions; Glyburide; Guinea Pigs; Hydrogen-Ion Concentration; Kinetics; Membrane Potentials; Muscle, Smooth, Vascular; Potassium Channels; Tolbutamide; Vasodilator Agents | 1992 |
ATP/ADP binding sites are present in the sulfonylurea binding protein associated with brain ATP-sensitive K+ channels.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Binding Sites; Binding, Competitive; Brain; Glyburide; Kinetics; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors; Swine; Tolbutamide | 1992 |
Specificity of photolabeling of beta-cell membrane proteins with an 125I-labeled glyburide analog.
Topics: Animals; Binding Sites; Cell Membrane; Chromatography, Gel; Cricetinae; Electrophoresis, Polyacrylamide Gel; Glipizide; Glyburide; Iodine Radioisotopes; Islets of Langerhans; Membrane Proteins; Photochemistry; Substrate Specificity; Tolbutamide; Tumor Cells, Cultured | 1992 |
Adverse effect on diabetes control of concomitant glibenclamide and tolbutamide.
Topics: Diabetes Mellitus, Type 2; Drug Interactions; Drug Therapy, Combination; Glyburide; Humans; Male; Middle Aged; Patient Acceptance of Health Care; Tolbutamide | 1991 |
Sulfonylurea enhances insulin-induced acetyl coenzyme A carboxylase activity in rat adipocytes.
Topics: Acetyl-CoA Carboxylase; Adipose Tissue; Animals; Enzyme Induction; Epinephrine; Glucagon; Glyburide; In Vitro Techniques; Insulin; Male; Rats; Rats, Inbred Strains; Sulfonylurea Compounds; Tolbutamide | 1991 |
Co-secretion of amylin and insulin from cultured islet beta-cells: modulation by nutrient secretagogues, islet hormones and hypoglycemic agents.
Topics: Amyloid; Animals; Arginine; Cell Line; Cricetinae; Glucagon; Glucose; Glyburide; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Islet Amyloid Polypeptide; Islets of Langerhans; Kinetics; Metformin; Somatostatin; Tolbutamide | 1991 |
Ion channels of glucose-responsive and -unresponsive beta-cells.
Topics: Animals; Cobalt; Electrophysiology; Glucose; Glyburide; Hemolytic Plaque Technique; In Vitro Techniques; Ion Channels; Islets of Langerhans; Male; Membrane Potentials; Potassium Channels; Potassium Chloride; Rats; Rats, Inbred Strains; Sodium Channels; Tolbutamide | 1991 |
Effects of glibenclamide and tolbutamide on ischemia- and ouabain-induced arrhythmias and membrane potentials of ventricular myocardium from rat and guinea pig.
Topics: Animals; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Female; Glyburide; Guinea Pigs; Hypoxia; Ischemia; Male; Membrane Potentials; Ouabain; Rats; Species Specificity; Tolbutamide; Ventricular Fibrillation | 1991 |
Activation by adrenaline of a low-conductance G protein-dependent K+ channel in mouse pancreatic B cells.
Topics: Animals; Clonidine; Epinephrine; Glucose; Glyburide; Islets of Langerhans; Membrane Potentials; Mice; Potassium Channels; Tolbutamide; Yohimbine | 1991 |
Sulfonylureas activate glucose transport and protein kinase C in rat adipocytes.
Topics: Adipose Tissue; Animals; Biological Transport; Deoxyglucose; Glucose; Glyburide; Insulin; Male; Protein Kinase C; Rats; Rats, Inbred Strains; Sulfonylurea Compounds; Tetradecanoylphorbol Acetate; Time Factors; Tolbutamide | 1991 |
Inhibitory effect of cyclosporine A on the activity of oral hypoglycemic agents in rats.
Topics: Administration, Oral; Animals; Blood Glucose; Cyclosporins; Dose-Response Relationship, Drug; Drug Interactions; Glyburide; Insulin; Male; Rats; Tissue Distribution; Tolbutamide | 1991 |
Possibility of ideal blood glucose control by a new oral hypoglycemic agent, N-[(trans-4-isopropylcyclohexyl)-carbonyl]-D-phenylalanine (A-4166), and its stimulatory effect on insulin secretion in animals.
Topics: Animals; Blood Glucose; Cyclohexanes; Diabetes Mellitus, Experimental; Dogs; Glucose Tolerance Test; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Mice; Mice, Mutant Strains; Nateglinide; Phenylalanine; Rats; Rats, Inbred Strains; Tolbutamide | 1991 |
Chronic exposure to glibenclamide impairs insulin secretion in isolated rat pancreatic islets.
Topics: Animals; Glyburide; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Rats, Inbred Strains; Time Factors; Tolbutamide | 1991 |
Characterization of the solubilized glibenclamide receptor in a hamster pancreatic beta-cell line, HIT T15.
Topics: Affinity Labels; Animals; Benzamides; Cell Line; Cricetinae; Glyburide; Islets of Langerhans; Photochemistry; Potassium Channels; Protein Binding; Receptors, Drug; Solubility; Tolbutamide | 1991 |
Sulfonylureas, ATP-sensitive K+ channels, and cellular K+ loss during hypoxia, ischemia, and metabolic inhibition in mammalian ventricle.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Binding Sites; Coronary Disease; Female; Glyburide; Guinea Pigs; Heart; In Vitro Techniques; Male; Myocardium; Oxygen Consumption; Potassium; Potassium Channels; Rabbits; Sulfonylurea Compounds; Tolbutamide | 1991 |
Effects of ATP-sensitive K+ channel blockers on the action potential shortening in hypoxic and ischaemic myocardium.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Disease; Dogs; Female; Glyburide; Guanidines; Guinea Pigs; Hypoxia; In Vitro Techniques; Male; Myocardial Contraction; Papillary Muscles; Perfusion; Pinacidil; Potassium Channels; Sulfonylurea Compounds; Tolbutamide | 1991 |
Hyperpolarization of denervated skeletal muscle by lemakalim and its antagonism by glybenclamide and tolbutamide.
Topics: Animals; Benzopyrans; Calcium Channel Blockers; Cesium; Cromakalim; Female; Glyburide; Male; Membrane Potentials; Mice; Muscle Denervation; Muscles; Pyrroles; Tolbutamide | 1991 |
B cell adrenoceptors and sulphonylurea-induced insulin release in mouse islets.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Female; Glyburide; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Metoprolol; Mice; Mice, Inbred Strains; Propanolamines; Propranolol; Receptors, Adrenergic, beta; Tolbutamide | 1990 |
Divergent cardiac effects of the first and second generation hypoglycemic sulfonylurea compounds.
Topics: Animals; Arrhythmias, Cardiac; Blood Glucose; Carbutamide; Dose-Response Relationship, Drug; Electrocardiography; Gliclazide; Glipizide; Glyburide; Hypoglycemic Agents; Male; Myocardial Infarction; Potassium; Rats; Rats, Inbred Strains; Reference Values; Structure-Activity Relationship; Tolbutamide | 1990 |
The potentiating effect of the simultaneous administration of tolbutamide, glibenclamide, and gliclazide on the development of alloxan-induced diabetes in rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Drug Synergism; Gliclazide; Glucose Tolerance Test; Glyburide; Insulin; Male; Pancreas; Rats; Rats, Inbred Strains; Sulfonylurea Compounds; Tolbutamide | 1990 |
Action of cromakalim on potassium membrane conductance in isolated heart myocytes of frog.
Topics: Adenosine Triphosphate; Animals; Barium; Benzopyrans; Cesium; Cromakalim; Glyburide; In Vitro Techniques; Membranes; Myocardium; Potassium Channels; Pyrroles; Rana esculenta; Sulfonylurea Compounds; Tolbutamide | 1990 |
A screening test for detecting sulfonylureas in plasma.
Topics: Aged; Aged, 80 and over; Chlorpropamide; Chromatography, High Pressure Liquid; Female; Gliclazide; Glipizide; Glyburide; Humans; Hypoglycemia; Male; Middle Aged; Sulfonylurea Compounds; Tolbutamide | 1990 |
Sulfonylurea-stimulated glucose transport association with diacylglycerollike activation of protein kinase C in BC3H1 myocytes.
Topics: Alkaloids; Animals; Biological Transport; Cell Line; Cells, Cultured; Deoxyglucose; Diglycerides; Dose-Response Relationship, Drug; Enzyme Activation; Glucose; Glyburide; Insulin; Muscles; Protein Kinase C; Staurosporine; Sulfonylurea Compounds; Tetradecanoylphorbol Acetate; Tolbutamide | 1990 |
Hypoglycemic sulfonylureas antagonize the effects of cromakalim and pinacidil on 86Rb fluxes and contractile activity in the rat aorta.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Glyburide; Guanidines; Hypoglycemic Agents; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Parasympatholytics; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes; Sulfonylurea Compounds; Tetraethylammonium Compounds; Tolbutamide; Vasodilator Agents | 1990 |
Adenosine triphosphate-sensitive potassium channels in anoxia.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Electrophysiology; Glyburide; Hippocampus; Hypoxia; Neurons; Potassium Channels; Tolbutamide | 1990 |
Effect of sulphonylurea therapy on insulin sensitivity in non insulin dependent diabetics.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Glipizide; Glyburide; Humans; Insulin Resistance; Middle Aged; Sulfonylurea Compounds; Time Factors; Tolbutamide | 1990 |
Tolbutamide excites rat glucoreceptive ventromedial hypothalamic neurones by indirect inhibition of ATP-K+ channels.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Binding Sites; Cerebral Cortex; Glyburide; In Vitro Techniques; Male; Potassium Channels; Rats; Rats, Inbred Strains; Tolbutamide; Ventromedial Hypothalamic Nucleus | 1990 |
Mechanism of potassium efflux and action potential shortening during ischaemia in isolated mammalian cardiac muscle.
Topics: Action Potentials; Animals; Bumetanide; Chlorides; Coronary Disease; Coumaric Acids; Deoxyglucose; Female; Glyburide; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Membrane Potentials; Myocardial Contraction; Papillary Muscles; Potassium; Purkinje Fibers; Sheep; Time Factors; Tolbutamide | 1990 |
Glibenclamide is a competitive antagonist of the thromboxane A2 receptor in dog coronary artery in vitro.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Coronary Vessels; Dogs; Endothelins; Endothelium, Vascular; Female; Glyburide; In Vitro Techniques; Isometric Contraction; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Peptides; Potassium Chloride; Prostaglandin Endoperoxides, Synthetic; Receptors, Prostaglandin; Receptors, Thromboxane; Thromboxane A2; Tolbutamide | 1990 |
The sulphonylurea receptor may be an ATP-sensitive potassium channel.
Topics: Adenosine Triphosphate; Animals; Cell Line; Cell Membrane; Glyburide; Insulin; Ion Channels; Islets of Langerhans; Rats; Sulfonylurea Compounds; Tolbutamide | 1985 |
Direct measurements of increased free cytoplasmic Ca2+ in mouse pancreatic beta-cells following stimulation by hypoglycemic sulfonylureas.
Topics: Aminoquinolines; Animals; Calcium; Cytoplasm; Female; Fluorescent Dyes; Glyburide; Hypoglycemic Agents; Ion Channels; Islets of Langerhans; Male; Mice; Mice, Obese; Potassium; Sulfonylurea Compounds; Tolbutamide | 1985 |
Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic beta-cells.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Cells, Cultured; Diazoxide; Glucose; Glyburide; Ion Channels; Islets of Langerhans; Mice; Potassium; Tolbutamide | 1986 |
Electrophysiological measurements show marked differences in the properties of the pancreatic beta-cell K-channels from albino mice and a strain of ob/ob (obese) mice.
Topics: Animals; Glucose; Glyburide; In Vitro Techniques; Ion Channels; Islets of Langerhans; Membrane Potentials; Mice; Mice, Obese; Potassium; Quinine; Species Specificity; Tolbutamide | 1986 |
Effect of channel blockers on potassium efflux from metabolically exhausted frog skeletal muscle.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Apamin; Barium; Cell Membrane Permeability; Decamethonium Compounds; Dose-Response Relationship, Drug; Electric Stimulation; Glyburide; In Vitro Techniques; Ion Channels; Muscles; Potassium; Quinine; Rana temporaria; Rubidium; Scorpion Venoms; Tetraethylammonium Compounds; Tolbutamide | 1987 |
Concentration-dependent effects of tolbutamide, meglitinide, glipizide, glibenclamide and diazoxide on ATP-regulated K+ currents in pancreatic B-cells.
Topics: Adenosine Triphosphate; Animals; Benzamides; Diazoxide; Glipizide; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Ion Channels; Islets of Langerhans; Mice; Mice, Inbred Strains; Potassium; Sulfonylurea Compounds; Tolbutamide | 1988 |
Inhibition by sulphonylureas of vasorelaxation induced by K+ channel activators in vitro.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Drug Interactions; Glipizide; Glyburide; Guanidines; In Vitro Techniques; Male; Nifedipine; Norepinephrine; Pinacidil; Potassium Channels; Potassium Chloride; Pyrroles; Rabbits; Sulfonylurea Compounds; Tolbutamide; Vasodilator Agents | 1989 |
The inotropic action of tolbutamide and glyburide.
Topics: Administration, Oral; Adult; Blood Glucose; Blood Pressure; Dobutamine; Epinephrine; Glyburide; Humans; Male; Myocardial Contraction; Norepinephrine; Propranolol; Stroke Volume; Tolbutamide | 1989 |
Glucose and sulfonylureas modify different phases of the membrane potential change during hypoxia in rat hippocampal slices.
Topics: Action Potentials; Animals; Cell Survival; Glucose; Glyburide; Hippocampus; Hypoxia, Brain; In Vitro Techniques; Male; Membrane Potentials; Rats; Rats, Inbred Strains; Sulfonylurea Compounds; Tolbutamide | 1989 |
Hyperpolarizing vasodilators activate ATP-sensitive K+ channels in arterial smooth muscle.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Benzopyrans; Cerebral Arteries; Cromakalim; Diazoxide; Glyburide; Guanidines; Mesenteric Arteries; Muscle, Smooth, Vascular; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Rats; Tolbutamide; Vasoactive Intestinal Peptide; Vasodilator Agents | 1989 |
Effects of tolbutamide, glibenclamide and diazoxide upon action potentials recorded from rat ventricular muscle.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Diazoxide; Glyburide; Heart; In Vitro Techniques; Male; Potassium Channels; Rats; Rats, Inbred Strains; Tolbutamide | 1989 |
Influence of ATP-sensitive potassium channel modulators on ischemia-induced fibrillation in isolated rat hearts.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Benzopyrans; Coronary Circulation; Coronary Disease; Cromakalim; Glyburide; Guanidines; Heart; Heart Rate; In Vitro Techniques; Male; Perfusion; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Tolbutamide; Vascular Resistance | 1989 |
Effects of sulfonamides on a metabolite-regulated ATPi-sensitive K+ channel in rat pancreatic B-cells.
Topics: Adenosine Triphosphate; Animals; Cells, Cultured; Diazoxide; Electric Conductivity; Glucose; Glyburide; Islets of Langerhans; Kinetics; Mathematics; Membrane Potentials; Models, Biological; Potassium Channels; Rats; Tolbutamide | 1989 |
ATP-sensitive K-channels in HIT T15 beta-cells studied by patch-clamp methods, 86Rb efflux and glibenclamide binding.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Binding Sites; Cell Line, Transformed; Cell Membrane Permeability; Cricetinae; Electric Conductivity; Glyburide; Islets of Langerhans; Potassium Channels; Rubidium Radioisotopes; Tolbutamide | 1989 |
[Effect of antidiabetics on post-exercise alaninemia in patients with non-insulin-dependent diabetes mellitus (type 2)].
Topics: Adult; Alanine; Diabetes Mellitus, Type 2; Drug Interactions; Drug Therapy, Combination; Exercise; Exercise Test; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Phenformin; Tolbutamide | 1989 |
Do hypoglycemic sulfonylureas inhibit Na+,K+-ATPase activity in pancreatic islets?
Topics: Animals; Calcimycin; Calcium; Cell Membrane Permeability; Drug Synergism; Glucose; Glyburide; Insulin; Ion Channels; Islets of Langerhans; Ouabain; Potassium; Quinine; Rats; Rubidium; Sodium-Potassium-Exchanging ATPase; Tolbutamide | 1985 |
Effect of tolbutamide and glyburide on cAMP-dependent protein kinase activity in rat liver cytosol.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Animals; Cyclic AMP; Cytosol; Dose-Response Relationship, Drug; Glyburide; Histones; Kinetics; Liver; Male; Protein Kinases; Rats; Rats, Inbred Strains; Tolbutamide | 1988 |
Interaction of sulfonylureas with pancreatic beta-cells. A study with glyburide.
Topics: Animals; Cyclic AMP; Glucagon; Glucose; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Male; Oxidation-Reduction; Rats; Rats, Inbred Strains; Tolbutamide | 1988 |
Effects of sulphonylureas on spontaneous motility and induced contractions in rat isolated uterus.
Topics: Animals; Calcium; Female; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Rats; Rats, Inbred Strains; Sulfonylurea Compounds; Tolbutamide; Uterine Contraction; Vanadates; Vanadium | 1986 |
Differential activities of tolbutamide, tolazamide, and glyburide in vitro on rabbit myocardial membrane Ca2+-transporting ATPase activity.
Topics: Animals; Calcium; Calcium-Transporting ATPases; Calmodulin; Cell Membrane; Female; Glyburide; Heart; In Vitro Techniques; Male; Milrinone; Myocardium; Pyridones; Rabbits; Thyroxine; Tolazamide; Tolbutamide | 1986 |
Increased cytosolic calcium. A signal for sulfonylurea-stimulated insulin release from beta cells.
Topics: Animals; Calcium; Cells, Cultured; Colforsin; Cricetinae; Cyclic AMP; Glyburide; Insulin; Islets of Langerhans; Tolbutamide; Verapamil | 1987 |
Relaxant effects of sulfonylureas on induced contractions of rat uterine smooth muscle: role of intracellular calcium.
Topics: Acetylcholine; Animals; Calcium; Female; Glyburide; In Vitro Techniques; Muscle, Smooth; Oxytocin; Rats; Rats, Inbred Strains; Sulfonylurea Compounds; Tolbutamide; Uterine Contraction | 1986 |
Potentiating effect of glibenclamide on the occurrence of alloxan diabetes in rats.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Synergism; Glyburide; Male; Rats; Rats, Inbred Strains; Tolbutamide | 1986 |
Effect of sulfonylureas on hepatic fatty acid oxidation.
Topics: Animals; Carnitine O-Palmitoyltransferase; Fatty Acids; Glyburide; Ketone Bodies; Liver; Male; Mitochondria, Liver; Oleic Acid; Oleic Acids; Oxidation-Reduction; Perfusion; Rats; Rats, Inbred Strains; Tolbutamide | 1986 |
[Importance of calcium in the interaction between prostaglandins E and sulfonylureas in utero].
Topics: Animals; Calcium; Dose-Response Relationship, Drug; Drug Interactions; Female; Glyburide; Muscle Relaxation; Oxytocin; Potassium Chloride; Pregnancy; Prostaglandins E; Rats; Rats, Inbred Strains; Tolbutamide; Uterine Contraction | 1986 |
Evidence for direct effect of tolbutamide on hepatic glycogenolysis induced by Ca2+-dependent hormones.
Topics: Angiotensin II; Animals; Calcium; Gluconeogenesis; Glyburide; Hormones; Liver Glycogen; Male; Phenylephrine; Rats; Rats, Inbred Strains; Tolbutamide; Trifluoperazine; Vasopressins | 1986 |
Mutagenic evaluation of tolbutamide and glybenclamide on the bone marrow cells of mice.
Topics: Animals; Bone Marrow; Dose-Response Relationship, Drug; Erythrocytes; Female; Glyburide; Male; Mice; Mutagenicity Tests; Mutagens; Tolbutamide | 1986 |
The hypoglycemic sulfonylureas glyburide and tolbutamide inhibit fatty acid oxidation by inhibiting carnitine palmitoyltransferase.
Topics: Acyltransferases; Animals; Carnitine O-Palmitoyltransferase; Diabetes Mellitus, Experimental; Fatty Acids; Glyburide; Male; Malonyl Coenzyme A; Mitochondria, Liver; Muscles; Myocardium; Rats; Rats, Inbred Strains; Tolbutamide | 1987 |
Regulation of muscle fructose 2, 6-bisphosphate levels by sulfonylureas.
Topics: Animals; Dose-Response Relationship, Drug; Fructosediphosphates; Glyburide; Hexosediphosphates; Mice; Muscles; Perfusion; Sulfonylurea Compounds; Tolbutamide | 1986 |
Stimulation of biliary glutathione secretion by sulfonylureas.
Topics: Animals; Bile; Biotransformation; Gallbladder; Glutathione; Glutathione Disulfide; Glyburide; Kinetics; Male; Perfusion; Rats; Rats, Inbred Strains; Tolbutamide | 1987 |
Direct effects of sulfonylurea agents on glucose transport in the BC3H-1 myocyte.
Topics: Animals; Cell Line; Deoxy Sugars; Deoxyglucose; Glipizide; Glyburide; Hypoglycemic Agents; Insulin; Kinetics; Mice; Muscles; Tolbutamide | 1987 |
Effect of PGE2 on sulfonylurea induced insulin release.
Topics: Animals; Blood Glucose; Dinoprostone; Female; Glyburide; Insulin; Insulin Secretion; Kinetics; Prostaglandins E; Rats; Rats, Inbred Strains; Sulfonylurea Compounds; Tolbutamide | 1987 |
Characterization of the sulfonylurea receptor on beta cell membranes.
Topics: Animals; ATP-Binding Cassette Transporters; Cell Line; Cell Membrane; Cricetinae; Glipizide; Glyburide; Insulin; Islets of Langerhans; Kinetics; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Compounds; Sulfonylurea Receptors; Temperature; Tolazamide; Tolbutamide | 1988 |
Effects of hypoglycemic sulfonylureas on catecholamine secretion and calcium uptake in cultured bovine adrenal chromaffin cells.
Topics: Adrenal Medulla; Animals; Calcimycin; Calcium; Catecholamines; Cattle; Cells, Cultured; Chromaffin Granules; Chromaffin System; Glyburide; Hypoglycemic Agents; Sulfonylurea Compounds; Tolbutamide | 1988 |
Sulfonylureas inhibit metabolic flux through rat liver pyruvate carboxylase reaction.
Topics: Acetyl Coenzyme A; Adenine Nucleotides; Animals; Coenzyme A; Glyburide; Kinetics; Male; Mitochondria, Liver; Oxygen Consumption; Pyruvate Carboxylase; Rats; Rats, Inbred Strains; Tolbutamide | 1988 |
Effects of sulphonylureas and diazoxide on insulin secretion and nucleotide-sensitive channels in an insulin-secreting cell line.
Topics: Adenosine Triphosphate; Animals; Cell Line; Diazoxide; Electrophysiology; Glucose; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Nucleotides; Potassium Channels; Rats; Sulfonylurea Compounds; Tolbutamide | 1988 |
[Correlation between the levels of CA19-9 and fasting plasma glucose in a case of diabetes mellitus].
Topics: Aged; Antigens, Tumor-Associated, Carbohydrate; Blood Glucose; Diabetes Mellitus; Female; Glyburide; Humans; Tolbutamide | 1988 |
Suppression by 2-ketoisocaproate of the insulinotropic action of hypoglycemic sulfonylureas.
Topics: Animals; Calcium; Gliclazide; Glucose; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Insulin; Insulin Secretion; Ionophores; Keto Acids; Oxidation-Reduction; Rats; Sulfonylurea Compounds; Tolbutamide | 1985 |
Stimulation of insulin secretion from isolated rat islets by SaRI 59-801.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Isoxazoles; Male; Mannoheptulose; Oxazoles; Proinsulin; Rats; Rats, Inbred Strains; Tolbutamide | 1985 |
Determination of glibenclamide, chlorpropamide and tolbutamide in plasma by high-performance liquid chromatography with ultraviolet detection.
Topics: Chlorpropamide; Chromatography, High Pressure Liquid; Diabetes Mellitus; Dinitrofluorobenzene; Gas Chromatography-Mass Spectrometry; Glyburide; Humans; Spectrophotometry, Ultraviolet; Tolbutamide | 1985 |
Effects of various hypoglycaemic sulphonylureas on the cardiotoxicity of glycosides.
Topics: Aged; Animals; Carbutamide; Cardiac Glycosides; Dose-Response Relationship, Drug; Female; Glyburide; Heart; Humans; Hypoglycemic Agents; Male; Middle Aged; Rabbits; Tolbutamide | 1985 |
Sulfonylurea stimulates liver fructose-2,6-bisphosphate formation in proportion to its hypoglycemic action.
Topics: Acetohexamide; Animals; Buformin; Chlorpropamide; Fructosediphosphates; Gliclazide; Gluconeogenesis; Glyburide; Glycolysis; Hexosediphosphates; In Vitro Techniques; Liver; Male; Rats; Rats, Inbred Strains; Stimulation, Chemical; Sulfamethoxazole; Sulfonylurea Compounds; Tolbutamide | 1985 |
Antidiuretic action of chlorpropamide.
Topics: Chlorpropamide; Diuresis; Female; Glyburide; Humans; Male; Tolbutamide | 1973 |
[Thyroid gland function of patients with diabetes in long-term use of glibornuride].
Topics: Camphanes; Carbutamide; Diabetes Mellitus; Female; Glyburide; Goiter; Humans; Hypoglycemic Agents; Male; Middle Aged; Sulfonylurea Compounds; Thyroid Function Tests; Thyroid Gland; Tolbutamide | 1972 |
The binding of sulphonylureas to serum albumin.
Topics: Animals; Carbon Radioisotopes; Cattle; Chlorpropamide; Glyburide; Humans; Hydrogen-Ion Concentration; Protein Binding; Serum Albumin; Serum Albumin, Bovine; Sulfonylurea Compounds; Tolazamide; Tolbutamide | 1974 |
Different amounts of insulin secretion following an equal total decrease of blood glucose as an indication of possible extrapancreatic activities of different sulfonylurea drugs.
Topics: Animals; Antigens; Autoanalysis; Blood Glucose; Camphanes; Computers; Diabetes Mellitus; Dogs; Fasting; Glyburide; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Pancreas; Sulfonylurea Compounds; Time Factors; Tolbutamide | 1973 |
The pancreatic -cell recognition of insulin secretagogues. IV. Islet uptake of sulfonylureas.
Topics: Animals; Antimycin A; Carbon Isotopes; Chlorpromazine; Diazoxide; Glucose; Glyburide; In Vitro Techniques; Islets of Langerhans; Leucine; Male; Mice; Serum Albumin; Sulfur Isotopes; Tolbutamide | 1973 |
[Insulin secretion after oral and intravenous administration of various 1st and 2d generation sulfonylurea derivatives in equipotential dosage].
Topics: Administration, Oral; Glyburide; Humans; Injections, Intravenous; Insulin; Insulin Secretion; Sulfonylurea Compounds; Tolbutamide | 1972 |
[Betacytotropic and antilipolytic effect of critical doses of tolbutamide and glibenclamide].
Topics: Blood Glucose; Fatty Acids, Nonesterified; Glyburide; Humans; Insulin; Tolbutamide | 1972 |
[Glibornuride, a new high-effective antidiabetic agent. Pharmacological and biochemical comparative studies in various animal species and animal experimental models].
Topics: Administration, Oral; Animals; Blood Glucose; Camphanes; Chemical Phenomena; Chemistry; Cholesterol; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Hyperglycemia; Hypoglycemia; Hypoglycemic Agents; Injections, Intravenous; Liver Glycogen; Mice; Microsomes, Liver; Oxidoreductases; Phospholipids; Rabbits; Rats; Sulfonylurea Compounds; Tolbutamide; Triglycerides | 1972 |
[Extrapancreatic effects of sulfonylurea compounds. 3. Studies on the additional blood sugar decreasing and antilipolytic effect of tolbutamide, glibornuride, and glibenclamide on completely pancreatectomized dogs, chronically treated with insulin during
Topics: Animals; Blood Glucose; Camphanes; Dogs; Fatty Acids, Nonesterified; Glyburide; Glycerol; Hyperglycemia; Hypoglycemic Agents; Infusions, Parenteral; Insulin; Lipid Metabolism; Pancreatectomy; Sulfonylurea Compounds; Time Factors; Tolbutamide | 1972 |
[Extrapancreatic effects of sulfonylurea compounds. IV. Increase of the effect of insulin due to tolbutamide, glibornuride, and glibenclamide in vitro].
Topics: Animals; Camphanes; Diaphragm; Dose-Response Relationship, Drug; Drug Interactions; Glucose; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Insulin; Mice; Sulfonylurea Compounds; Tolbutamide | 1972 |
[Insulin liberation by blood sugar decreasing sulfonamides and by glucose in adult diabetic patients].
Topics: Adult; Azepines; Blood Glucose; Diabetes Mellitus; Drug Interactions; Fatty Acids, Nonesterified; Glucose; Glyburide; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Oxazoles; Stimulation, Chemical; Sulfonylurea Compounds; Tolbutamide | 1972 |
[Studies on dose-response relationship of various sulfonylurea derivatives of the old and the new generation with further hints to extrapancreatic mechanisms of decreasing blood sugar].
Topics: Administration, Oral; Azepines; Blood Glucose; Dose-Response Relationship, Drug; Glyburide; Humans; Hypoglycemic Agents; Injections, Intravenous; Insulin; Insulin Secretion; Oxazoles; Sulfonylurea Compounds; Tolbutamide | 1972 |
Interrelationship of islet metabolism, adenosine triphosphate content and insulin release.
Topics: Adenosine Triphosphate; Animals; Carbon Isotopes; Glucose; Glyburide; Glyceraldehyde; Heptoses; Hexoses; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Male; Mice; Models, Biological; Nitriles; Oxidative Phosphorylation; Phenylhydrazines; Time Factors; Tolbutamide; Uncoupling Agents | 1973 |
Observations of the mechanism of action of the sulfonylureas under clinical conditions.
Topics: Adult; Aged; Blood Glucose; Chlorpropamide; Diabetes Mellitus; Fasting; Female; Glyburide; Humans; Hypoglycemia; Insulin; Male; Middle Aged; Time Factors; Tolbutamide | 1973 |
The effect of glibenclamide on non-esterified fatty acid levels in the plasma of the severely alloxan diabetic rat.
Topics: Animals; Blood Glucose; Chlorpropamide; Diabetes Mellitus, Experimental; Fatty Acids, Nonesterified; Glyburide; Insulin; Male; Rats; Tolbutamide | 1973 |
[Secretion of insulin under the influence of sulfonylurea derivates (SH)].
Topics: Animals; Blood Glucose; Diabetes Mellitus; Glucose Tolerance Test; Glyburide; Humans; Insulin; Insulin Secretion; Pancreas; Stimulation, Chemical; Sulfonylurea Compounds; Tolbutamide | 1973 |
Effects of feeding and fasting on the insulin secretory response to glucose and sulfonylureas in intact rats and isolated perfused rat pancreas.
Topics: Animal Nutritional Physiological Phenomena; Animals; Fasting; Glucose; Glucose Tolerance Test; Glyburide; In Vitro Techniques; Insulin; Insulin Secretion; Male; Pancreas; Perfusion; Rats; Rats, Inbred Strains; Stimulation, Chemical; Sulfonylurea Compounds; Tolbutamide | 1973 |
[A comparison of intravenous tolbutamide and insulin administration during and after operation in patients with maturity-onset diabetes (author's transl)].
Topics: Administration, Oral; Age Factors; Aged; Anesthesia, General; Blood Glucose; Carbohydrates; Carbutamide; Chlorpropamide; Diabetes Complications; Diabetes Mellitus; Diet Therapy; Fructose; Glyburide; Glycosuria; Humans; Injections, Intravenous; Insulin; Ketone Bodies; Plasma Substitutes; Postoperative Care; Preoperative Care; Surgical Procedures, Operative; Tolbutamide | 1974 |
Insulinotrophic drugs. Effect on intestinal abosorption of sugar.
Topics: Animals; Azepines; Biological Transport; Ethers; Galactose; Glyburide; Hypoglycemic Agents; Ileum; Intestinal Absorption; Intestine, Small; Oxazoles; Perfusion; Pyrimidines; Rats; Sulfonamides; Sulfonylurea Compounds; Tolbutamide | 1974 |
Effect of sulfonylureas on the secretion of pancreatic immunoreactive glucagon and enteric glucagon-like immunoreactivity.
Topics: Animals; Antibody Formation; Antigens; Arginine; Glucagon; Glucose; Glyburide; In Vitro Techniques; Insulin Antibodies; Pancreas; Radioimmunoassay; Rats; Sulfonylurea Compounds; Theophylline; Tolbutamide | 1973 |
[Pharmacological aspects of comparative studies on different blood sugar-lowering sulfonylureas].
Topics: Administration, Oral; Animals; Autoanalysis; Biopharmaceutics; Blood Glucose; Dogs; Dose-Response Relationship, Drug; Glyburide; Humans; Hypoglycemic Agents; Injections, Intravenous; Insulin; Sulfonylurea Compounds; Time Factors; Tolbutamide | 1973 |
[Hypoglycemia caused by oral antidiabetic agents].
Topics: Adult; Aged; Chlorpropamide; Delayed-Action Preparations; Diet; Female; Glyburide; Humans; Hypoglycemia; Hypoglycemic Agents; Kidney Diseases; Liver Diseases; Male; Middle Aged; Phenformin; Tolazamide; Tolbutamide | 1973 |
Interactions of sulfonylureas with plasma proteins.
Topics: Acetohexamide; Acridines; Aniline Compounds; Animals; Binding Sites; Blood Proteins; Cattle; Chlorpropamide; Cyclohexanes; Glyburide; Humans; Hypoglycemic Agents; Naphthalenesulfonates; Protein Binding; Pyrazines; Serum Albumin; Serum Albumin, Bovine; Spectrometry, Fluorescence; Sulfonylurea Compounds; Tolbutamide; Warfarin | 1974 |
[Insulin secretion following combined administration of glucose and different sulfonylurea compounds in equipotential doses in metabolically healthy persons].
Topics: Camphanes; Glucose; Glyburide; Humans; Insulin; Insulin Secretion; Sulfonylurea Compounds; Tolbutamide | 1973 |
Effects of hypoglycemic sulfonamides on glucagon and insulin secretion in ducks and dogs.
Topics: Animals; Antigens; Arteries; Blood Glucose; Carboxylic Acids; Dogs; Ducks; Ethers; Femoral Artery; Glucagon; Glyburide; Hypoglycemic Agents; Injections, Intravenous; Insulin; Insulin Secretion; Pancreas; Pyrimidines; Species Specificity; Sulfonamides; Tolbutamide; Veins | 1974 |
An inhibitory effect of tolbutamide and glibenclamide (glyburide) on the pancreatic islets of normal animals.
Topics: Animals; Blood Glucose; Carbon Radioisotopes; Female; Glucose; Glyburide; Insulin; Islets of Langerhans; Leucine; Tolbutamide | 1974 |
In vitro secretion of insulin after glucose, sulphonylureas, adrenergic and cholinergic substances studied by isolated perfused rat pancreas.
Topics: Acetylcholine; Animals; Atropine; Diazoxide; Epinephrine; Glucagon; Glucose; Glyburide; Heptoses; In Vitro Techniques; Insulin; Insulin Secretion; Isoproterenol; Ketoses; Norepinephrine; Pancreas; Parasympathomimetics; Perfusion; Phenoxybenzamine; Practolol; Propranolol; Sulfonylurea Compounds; Theophylline; Tolbutamide | 1974 |
[Insulin secretion after administration of sulfonylurea in normal and diabetic subjects].
Topics: Diabetes Mellitus; Fatty Acids, Nonesterified; Female; Glucose Tolerance Test; Glyburide; Growth Hormone; Humans; Insulin; Insulin Secretion; Male; Radioimmunoassay; Tolbutamide | 1974 |
Clinical assessment of glybenclamide (daonil) in diabetes mellitus.
Topics: Chlorpropamide; Diabetes Mellitus; Female; Glyburide; Humans; Male; Tolbutamide | 1973 |
Uptake of glibornuride by microdissected pancreatic islets.
Topics: Animals; Biological Transport; Camphanes; Carbon Radioisotopes; Female; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Obesity; Pancreas; Sucrose; Sulfonylurea Compounds; Time Factors; Tolbutamide; Tritium | 1974 |
[Single intravenous glibenclamide-glucose loading as a prediction test (author's transl)].
Topics: Adult; Age Factors; Aged; Diabetes Mellitus; Female; Glucose Tolerance Test; Glyburide; Humans; Insulin; Insulin Antibodies; Insulin Secretion; Long-Term Care; Male; Middle Aged; Tolbutamide | 1974 |
[Pharmacologic study with glisoxepide and other blood sugar reducing sulfonamide derivatives in metabolically healthy subjects and diabetics].
Topics: Administration, Oral; Autoanalysis; Azepines; Blood Glucose; Depression, Chemical; Diabetes Mellitus; Dose-Response Relationship, Drug; Drug Evaluation; Glyburide; Humans; Hypoglycemic Agents; Injections, Intravenous; Insulin; Oxazoles; Sulfonamides; Sulfonylurea Compounds; Time Factors; Tolbutamide | 1974 |
Potentiating effects of drugs on the binding of glibenclamide to pancreatic beta cells.
Topics: Animals; Binding Sites; Drug Synergism; Female; Glyburide; Hyperglycemia; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Phenylbutazone; Serum Albumin; Sucrose; Sulfaphenazole; Sulfisomidine; Sulfisoxazole; Sulfonamides; Tolbutamide | 1974 |
Effect of hypoglycemic sulfonylureas on hepatic fructose metabolism in the rat.
Topics: Acetoacetates; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Chlorpropamide; Fasting; Flavoproteins; Fructose; Gluconeogenesis; Glyburide; Hydrogen-Ion Concentration; Hydroxybutyrates; Hypoglycemia; Ketone Bodies; Liver; Male; Mitochondria, Liver; Oxidation-Reduction; Perfusion; Rats; Spectrometry, Fluorescence; Sulfonylurea Compounds; Time Factors; Tolbutamide | 1974 |
[The glibenclamide-phenformin combination in the therapy of diabetes mellitus].
Topics: Adult; Aged; Biguanides; Blood Glucose; Chlorpropamide; Diabetes Mellitus; Drug Combinations; Drug Evaluation; Drug Synergism; Female; Glyburide; Humans; Insulin; Male; Middle Aged; Phenformin; Tolbutamide | 1974 |
[Oral antidiabetic therapy with delayed-action glibenclamide and phenformin in fixed combination].
Topics: Adult; Aged; Blood Glucose; Carbutamide; Cholesterol; Delayed-Action Preparations; Diabetes Mellitus; Drug Combinations; Evaluation Studies as Topic; Fatty Acids, Nonesterified; Female; Glyburide; Glycosuria; Humans; Lipids; Male; Metformin; Middle Aged; Phenformin; Tolbutamide; Triglycerides | 1974 |
Zinc and insulin content in pancreatic islets of rats after administration of hypoglycemic sulfonamides.
Topics: Animals; Blood Glucose; Chlorpropamide; Glyburide; Histocytochemistry; Hypoglycemic Agents; Insulin; Islets of Langerhans; Male; Rats; Tolbutamide; Zinc | 1974 |
Investigations on the antilipolytic activity of sulfonylureas in man with indications on limit dosages concerning their insulin-secreting properties.
Topics: Blood Glucose; Body Weight; Dose-Response Relationship, Drug; Fatty Acids, Nonesterified; Glyburide; Humans; Insulin; Lipid Mobilization; Male; Time Factors; Tolbutamide | 1974 |
Oral management of uncomplicated maturity onset diabetes.
Topics: Adult; Aged; Biguanides; Chlorpropamide; Diabetes Mellitus; Diet; Drug Combinations; Glucose Tolerance Test; Glyburide; Humans; Hypoglycemic Agents; Insulin; Middle Aged; Obesity; Sulfonylurea Compounds; Tolbutamide | 1974 |
[Studies on the course of mass screening in discovered diabetic patients].
Topics: Adolescent; Adult; Aged; Biguanides; Child; Diabetes Mellitus; Diet, Diabetic; Female; Glyburide; Humans; Insulin; Male; Mass Screening; Middle Aged; Obesity; Tolbutamide | 1974 |
[Recent pharmacologic aspects of sulfamides modifying insulin secretion (hypoglycemic and hyperglycemic sulfamides)].
Topics: Animals; Catecholamines; Diazoxide; Dogs; Dose-Response Relationship, Drug; Drug Antagonism; Drug Synergism; Glucose; Glyburide; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Isoproterenol; Pancreas; Pancreatectomy; Phenoxybenzamine; Propranolol; Rats; Tolbutamide | 1973 |
[Propranolol and hypoglycemic sulfonamides. Study on insulin secretion and blood sugar].
Topics: Animals; Blood Glucose; Dogs; Drug Antagonism; Drug Synergism; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Perfusion; Propranolol; Radioimmunoassay; Rats; Tolbutamide | 1971 |
Proceedings: Half-life of phenprocoumarol (Marcumar R) during treatment with insulin and sulfonylureas in diabetics.
Topics: Benzyl Compounds; Blood Glucose; Coumarins; Diabetes Mellitus; Glyburide; Half-Life; Humans; Insulin; Prothrombin Time; Sulfonylurea Compounds; Tolbutamide | 1974 |
Biochemical and morphological events associated with the development of fetal rat pancreas "in vivo" and "in vitro": effect of glucagon and of other agents.
Topics: Animals; Caffeine; Cell Differentiation; Culture Techniques; Cyclic AMP; Glucagon; Glucose; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Pancreas; Pyruvates; Rats; Sulfonylurea Compounds; Tolbutamide | 1970 |
The mode of action of adenosine 3':5'-cyclic monophosphate in mammalian islets of Langerhans. Effects of insulin secretagogues on islet-cell protein kinase activity.
Topics: Animals; Arginine; Caffeine; Cyclic AMP; Diazoxide; Epinephrine; Glucagon; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Leucine; Male; Phosphorus Isotopes; Phosphotransferases; Protein Kinases; Rats; Theophylline; Time Factors; Tolbutamide; Xanthines; Xylitol | 1973 |
Inhibition of glucose-induced insulin secretion in trypsin-treated islets of Langerhans.
Topics: Animals; Calcium; Cells, Cultured; Cellulose; Electrophoresis; Glucose; Glyburide; Humans; In Vitro Techniques; Insulin; Insulin Antibodies; Insulin Secretion; Islets of Langerhans; Magnesium; Male; Methods; Microbial Collagenase; Radioimmunoassay; Rats; Time Factors; Tolbutamide; Trypsin | 1973 |
Significance of acid amyloglucosidase in sulphonylurea-induced insulin release.
Topics: Adenylyl Cyclases; Albumins; Amylases; Animals; Blood Glucose; Carbutamide; Cyclic AMP; Dose-Response Relationship, Drug; Fasting; Female; Glucuronidase; Glyburide; Glycoside Hydrolases; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Mice, Inbred Strains; Norepinephrine; Phosphoric Diester Hydrolases; Rats; Secretin; Sulfonylurea Compounds; Tolbutamide; Xanthines | 1974 |
Role of calcium and cyclic adenosine 3',5'-monophosphate in the antilipolytic effect of tolbutamide and glibenclamide.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipose Tissue; Adrenocorticotropic Hormone; Animals; Bucladesine; Calcium; Carboxylic Acids; Cyclic AMP; Epinephrine; Glucagon; Glyburide; Isoproterenol; Lipid Metabolism; Male; Norepinephrine; Rats; Theophylline; Tolbutamide | 1974 |
[Influence of an alpha- and beta-receptor blockade on the dynamics of insulin secretion in dogs following increased dosage of various sulfonylureas].
Topics: 1-Propanol; Adrenergic beta-Antagonists; Amino Alcohols; Animals; Blood Glucose; Cresols; Dogs; Glyburide; Insulin; Insulin Secretion; Phentolamine; Propylamines; Sulfonylurea Compounds; Tolbutamide | 1971 |
Haemolytic anaemia associated with antibodies to tolbutamide and phenacetin.
Topics: Anemia, Hemolytic; Antibodies; Chlorpropamide; Coombs Test; Cross Reactions; Female; Glyburide; Humans; Middle Aged; Phenacetin; Tolbutamide | 1972 |
[Advantages and hazards of oral antidiabetics].
Topics: Administration, Oral; Diabetes Mellitus; Diet Therapy; Glyburide; Humans; Hypoglycemia; Hypoglycemic Agents; Tolbutamide | 1972 |
[Role of glibenclamide in the therapy of diabetes].
Topics: Adult; Chlorpropamide; Diabetes Mellitus; Evaluation Studies as Topic; Glyburide; Glycosuria; Humans; Insulin; Insulin Secretion; Sulfonylurea Compounds; Tolbutamide | 1972 |
A dose equivalence study of glybenclamide (daonil)--a new hypoglycaemic agent.
Topics: Adult; Chlorpropamide; Diabetes Mellitus; Female; Glyburide; Humans; Male; Sulfonylurea Compounds; Therapeutic Equivalency; Tolbutamide | 1972 |
[Infantile diabetes and treatment with oral hypoglycemizing agents (function tests of the endocrine pancreatic before and after one year of therapy)].
Topics: Child; Child, Preschool; Diabetes Mellitus, Type 1; Female; Glucose Tolerance Test; Glyburide; Humans; Insulin; Male; Pancreas; Phenformin; Sulfonylurea Compounds; Tolbutamide | 1972 |
Oral therapy in diabetes.
Topics: Acetohexamide; Administration, Oral; Animals; Chlorpropamide; Diabetes Mellitus; Diet Therapy; Evaluation Studies as Topic; Glyburide; Humans; Hypoglycemic Agents; Insulin; Metformin; Obesity; Phenformin; Pyrimidines; Sulfonamides; Time Factors; Tolbutamide | 1972 |
The effect of tolbutamide and glibenclamide on the incorporation of ( 3 H)leucine and on the conversion of proinsulin to insulin in isolated pancreatic islets.
Topics: Animals; Chromatography, Gel; Depression, Chemical; Glucose; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Isotope Labeling; Leucine; Male; Mice; Proinsulin; Rats; Time Factors; Tolbutamide; Tritium | 1972 |
The effects of tolbutamide and glibenclamide on intestinal glucose absorption.
Topics: Aerobiosis; Anaerobiosis; Animals; Blood Glucose; Body Weight; Glucose; Glyburide; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Jejunum; Male; Rats; Sulfonylurea Compounds; Time Factors; Tolbutamide | 1972 |
Diabetes mellitus: the thin maturity-onset diabetic.
Topics: Acetohexamide; Body Weight; Chlorpropamide; Diabetes Mellitus; Glyburide; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Male; Middle Aged; Tolazamide; Tolbutamide | 1972 |
[Recent findings in the use of 1st and 2nd generation hypoglycemic sulfonamides].
Topics: Adult; Azepines; Blood Glucose; Dose-Response Relationship, Drug; Glucose; Glucose Tolerance Test; Glyburide; Humans; Hypoglycemic Agents; Insulin; Oxazoles; Pancreas; Sulfonylurea Compounds; Tolbutamide | 1973 |
[The effect of oral antidiabetics on the biosynthesis of proinsulin in the rat].
Topics: Animals; Chromatography, Gel; Electrophoresis, Disc; Glucose; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Islets of Langerhans; Leucine; Male; Proinsulin; Pyrimidines; Rats; Sulfonic Acids; Sulfonylurea Compounds; Tolbutamide; Tritium | 1972 |
[Incidence and severity of treatment-induced hypoglycemias in diabetics].
Topics: Aged; Diabetes Mellitus; Diet, Diabetic; Female; Glyburide; Hemiplegia; Humans; Hypoglycemia; Insulin; Male; Middle Aged; Sulfonylurea Compounds; Tolbutamide | 1971 |
[ADH-like mechanism of action of chlorpropamide in diabetes insipidus (a comparison with the antidiuretic effect of other blood glucose decreasing sulfonamides and hydrochlorothiazide)].
Topics: Aged; Blood Glucose; Body Weight; Chlorpropamide; Depression, Chemical; Diabetes Insipidus; Diuresis; Female; Glyburide; Humans; Hydrochlorothiazide; Hypoglycemic Agents; Male; Middle Aged; Natriuresis; Osmolar Concentration; Potassium; Sulfonylurea Compounds; Tolbutamide; Vasopressins | 1970 |
In vitro effect of various hypoglycemic agents on the hepatic and pancreatic protein synthesis in the rat.
Topics: Animals; Cell-Free System; Depression, Chemical; Ethers; Female; Glyburide; Hypoglycemic Agents; Leucine; Liver; Male; Metabolism; Pancreas; Protein Biosynthesis; Pyrimidines; Rats; Rats, Inbred Strains; Sulfonylurea Compounds; Terpenes; Tolbutamide; Tritium | 1971 |
Treatment with glibenclamide in maturity-onset diabetes mellitus.
Topics: Age Factors; Aged; Diabetes Mellitus; Diet, Diabetic; Female; Glyburide; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Sulfonylurea Compounds; Tolbutamide | 1971 |
Immunohistological demonstration of insulin in islets of langerhans after stimulation of insulin secretion by glucose, sulphonylureas and insulin antibodies.
Topics: Animals; Fluorescent Antibody Technique; Formaldehyde; Freeze Drying; Glucose; Glyburide; Histological Techniques; Insulin; Insulin Antibodies; Insulin Secretion; Islets of Langerhans; Male; Methods; Pancreas; Rats; Stimulation, Chemical; Sulfonylurea Compounds; Tolbutamide | 1971 |
Pharmacodynamic aspects of tolbutamide, glibenclamide, glibornuride and glisoxepide. I. Dose response relations and repeated administration in diabetic subjects.
Topics: Adult; Blood Glucose; Diabetes Mellitus; Glyburide; Humans; Injections, Intravenous; Insulin; Insulin Secretion; Sulfonylurea Compounds; Tolbutamide | 1971 |
Pharmacodynamic aspects of tolbutamide, glibenclamide, glibornuride, and glisoxepide. II. Repeated administration in combination with glucose.
Topics: Adult; Blood Glucose; Glucose; Glyburide; Humans; Injections, Intravenous; Insulin; Insulin Secretion; Sulfonylurea Compounds; Tolbutamide | 1971 |
[Synergism between oral diabetics and insulin].
Topics: Animals; Biguanides; Blood Glucose; Chlorpropamide; Columbidae; Drug Synergism; Glyburide; Hypoglycemia; Hypoglycemic Agents; Insulin; Tolbutamide | 1971 |
Clinical experiences in oral antidiabetic therapy with sulphonylureas and biguanides.
Topics: Aged; Biguanides; Blood Glucose; Diabetes Mellitus; Glyburide; Humans; Insulin; Middle Aged; Phenformin; Sulfonylurea Compounds; Tolbutamide | 1971 |
[Studies on the effect of various sulfonylureas during adrenergic blockade of the insulin secretion in man].
Topics: Blood Glucose; Catecholamines; Drug Antagonism; Epinephrine; Fatty Acids, Nonesterified; Glyburide; Glycerol; Humans; Insulin; Insulin Secretion; Norepinephrine; Sulfonylurea Compounds; Tolbutamide | 1971 |
[Changes of blood sugar, serum insulin and free fatty acids following tolbutamide and glibenclamide in subjects of normal metabolism, pretreated with alpha and beta receptor blockaders].
Topics: Blood Glucose; Fatty Acids, Nonesterified; Glyburide; Humans; Insulin; Phentolamine; Propranolol; Tolbutamide | 1971 |
Suppressive effect of long term sulfonylurea treatment on A, B, and D cells of normal rat pancreas.
Topics: Animals; Arginine; Glucagon; Glucose; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Rats, Inbred Strains; Somatostatin; Time Factors; Tolbutamide | 1983 |
Glibenclamide is exceptional among hypoglycaemic sulphonylureas in accumulating progressively in beta-cell-rich pancreatic islets.
Topics: Animals; Carbutamide; Chlorpropamide; Glipizide; Glyburide; Islets of Langerhans; Mice; Mice, Obese; Sulfonylurea Compounds; Tolbutamide | 1984 |
Effects of sulfonylureas on membrane-bound low Km cyclic AMP phosphodiesterase in rat fat cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Acetohexamide; Adipose Tissue; Animals; Buformin; Glyburide; Isoproterenol; Kinetics; Male; Rats; Rats, Inbred Strains; Sulfonylurea Compounds; Tolbutamide | 1982 |
Thiol-dependent and non-thiol-dependent stimulations of insulin release.
Topics: Animals; Bucladesine; Calcimycin; Calcium; Diamide; Dose-Response Relationship, Drug; Female; Glucose; Glutathione; Glyburide; Glyceraldehyde; Insulin; Insulin Secretion; Islets of Langerhans; Isoproterenol; Leucine; Male; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Tolbutamide | 1984 |
Tolbutamide and glyburide differ in effectiveness to displace alpha- and beta-adrenergic radioligands in pancreatic islet cells and membranes.
Topics: Alprenolol; Animals; Cell Membrane; Clonidine; Dihydroalprenolol; Epinephrine; Glyburide; Islets of Langerhans; Male; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Tolbutamide | 1984 |
Clinical pharmacology of glipizide.
Topics: Biological Availability; Blood Glucose; Chlorpropamide; Diabetes Mellitus, Type 2; Glipizide; Glyburide; Half-Life; Humans; Kinetics; Structure-Activity Relationship; Sulfonylurea Compounds; Tolbutamide | 1983 |
[Hypoglycemic effects of the blended Chinese traditional medicines in genetically and chemically diabetic mice].
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glyburide; Hypoglycemic Agents; Male; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Metformin; Mice; Tolbutamide | 1984 |
Effects of cations, ionophores and hypoglycemic sulfonylureas on the fluorescence of fluorescein-labelled pancreatic islets.
Topics: Animals; Calcimycin; Calcium; Fluoresceins; Fluorescence; Glyburide; Hydrogen-Ion Concentration; Hypoglycemic Agents; Islets of Langerhans; Lasalocid; Potassium; Rats; Tolbutamide | 1984 |
Effect of glibenclamide on the osmotic resistance of pancreatic beta-cells.
Topics: Animals; Cell Membrane; Culture Media; Glyburide; Imipramine; Islets of Langerhans; Mice; Mice, Obese; Osmolar Concentration; Tetracaine; Tolbutamide | 1984 |
The control of 86Rb efflux from rat isolated pancreatic islets by the sulphonylureas tolbutamide and glibenclamide.
Topics: Animals; Biological Transport; Calcium; Cell Membrane; Cell Membrane Permeability; Cobalt; Glyburide; In Vitro Techniques; Islets of Langerhans; Male; Potassium; Radioisotopes; Rats; Rats, Inbred Strains; Rubidium; Tolbutamide | 1984 |
Effects of tolbutamide and glyburide on glucose and acetate incorporation into aortic lipids of the dog.
Topics: Acetates; Animals; Aorta; Dogs; Glucose; Glyburide; Lipid Metabolism; Tolbutamide | 1980 |
Glipizide: experimental study and comparison with other sulfonylureas.
Topics: Animals; Blood Glucose; Dogs; Dose-Response Relationship, Drug; Glipizide; Glyburide; Hypoglycemia; Insulin; Islets of Langerhans; Mice; Rats; Sulfonylurea Compounds; Tolbutamide | 1980 |
Kinetics-effect relations of glipizide and other sulfonylureas.
Topics: Blood Glucose; Chlorpropamide; Diabetes Mellitus; Dose-Response Relationship, Drug; Fasting; Feeding Behavior; Glipizide; Glyburide; Humans; Kidney; Sulfonylurea Compounds; Tolbutamide | 1980 |
Comparative single-dose kinetics and effects of four sulfonylureas in healthy volunteers.
Topics: Adult; Blood Glucose; Chlorpropamide; Fasting; Glipizide; Glyburide; Humans; Insulin; Kinetics; Male; Sulfonylurea Compounds; Time Factors; Tolbutamide | 1980 |
The pharmacology of sulfonylureas.
Topics: Acetohexamide; Blood Glucose; Chlorpropamide; Diabetes Mellitus; Glyburide; Humans; Insulin; Sulfonylurea Compounds; Tolazamide; Tolbutamide | 1981 |
Lipoprotein patterns in diet, sulphonylurea, and insulin treated diabetics.
Topics: Adult; Aged; Blood Glucose; Body Weight; Diabetes Mellitus; Diet, Diabetic; Female; Glyburide; Humans; Insulin; Lipoproteins; Male; Middle Aged; Tolbutamide | 1981 |
IRI-secretion in MOD with and without SU (5 year control).
Topics: Blood Glucose; Diabetes Mellitus; Glucagon; Glyburide; Humans; Insulin; Middle Aged; Tolbutamide | 1980 |
Long-term actions of sulfonylureas on (Pro-) insulin biosynthesis and secretion. III. Functional state of isolated pancreatic rat islets after culture in the presence of tolbutamide and glibenclamide.
Topics: Animals; Cells, Cultured; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Proinsulin; Rats; Tolbutamide | 1981 |
Serum glycohydrolases in compensated & decompensated alloxan diabetic rabbits.
Topics: Animals; Diabetes Mellitus, Experimental; Glyburide; Glycoside Hydrolases; Insulin; Kinetics; Male; Rabbits; Tolbutamide | 1981 |
[The effect of tolbutamide and glibenclamide on HDL-cholesterol levels].
Topics: Glyburide; Humans; Lipoproteins, HDL; Tolbutamide | 1982 |
Reconstitution of a KATP channel from basolateral membranes of Necturus enterocytes.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Diazoxide; Glyburide; Intestine, Small; Membranes; Necturus; Potassium Channels; Tolbutamide | 1995 |
Inhibition of liver microsomal carnitine acyltransferases by sulphonylurea drugs.
Topics: Animals; Carnitine Acyltransferases; Glyburide; Lipoproteins, VLDL; Liposomes; Male; Malonyl Coenzyme A; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Tolbutamide; Triglycerides | 1995 |
Dissociation of KATP channel and sulphonylurea receptor in the rat clonal insulin-secreting cell line, CRI-D11.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Cell Membrane; Clone Cells; Glyburide; Insulin; Insulin Secretion; Insulinoma; Membrane Potentials; Pancreatic Neoplasms; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Sulfonylurea Receptors; Tetradecanoylphorbol Acetate; Tolbutamide; Tumor Cells, Cultured | 1993 |
Regulation of a potassium conductance in rat midbrain dopamine neurons by intracellular adenosine triphosphate (ATP) and the sulfonylureas tolbutamide and glibenclamide.
Topics: Adenosine Triphosphate; Animals; Dopamine; Electric Conductivity; Glyburide; Homeostasis; In Vitro Techniques; Male; Membrane Potentials; Mesencephalon; Neurons; Patch-Clamp Techniques; Potassium; Potassium Channels; Rats; Rats, Wistar; Tolbutamide | 1995 |
Characterization of ATP-sensitive potassium channel-blocking activity of ZENECA ZM181,037, a eukalemic diuretic.
Topics: Acetamides; Adenosine Triphosphate; Administration, Oral; Animals; Benzopyrans; Blood Glucose; Blood Pressure; Cromakalim; Diuretics; Dogs; Dose-Response Relationship, Drug; Electrophysiology; Glyburide; Guinea Pigs; Hypertension; In Vitro Techniques; Injections, Intravenous; Male; Muscle Relaxation; Muscle, Smooth; Muscle, Smooth, Vascular; Potassium Channel Blockers; Pyrroles; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Stereoisomerism; Tolbutamide | 1994 |
Location of the sulphonylurea receptor at the cytoplasmic face of the beta-cell membrane.
Topics: Animals; ATP-Binding Cassette Transporters; Cells, Cultured; Cytoplasm; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Solubility; Sulfonylurea Receptors; Tolbutamide | 1994 |
Tolbutamide suppresses slow and medium afterhyperpolarization in hippocampal slices.
Topics: Animals; Electric Stimulation; Evoked Potentials; Glyburide; Hippocampus; In Vitro Techniques; Neurons; Rats; Rats, Sprague-Dawley; Tolbutamide | 1994 |
Influence of ranitidine on the hypoglycaemic activity of glibenclamide and tolbutamide in rabbits.
Topics: Animals; Drug Interactions; Glyburide; Hypoglycemia; Rabbits; Ranitidine; Tolbutamide | 1994 |
Spontaneous activation of KATP current in rat dorsal vagal neurones.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Diffusion; Female; Glyburide; Male; Membrane Potentials; Neurons; Potassium Channels; Rats; Rats, Wistar; Tetraethylammonium Compounds; Tolbutamide; Vagus Nerve | 1994 |
Tetraethylammonium selectively stimulates secretion from noradrenergic bovine chromaffin cells.
Topics: 4-Aminopyridine; Animals; Calcium; Catecholamines; Cattle; Cells, Cultured; Chromaffin System; Drug Interactions; Drug Synergism; Epinephrine; Glyburide; Nifedipine; Norepinephrine; Ouabain; Phorbol 12,13-Dibutyrate; Potassium Channel Blockers; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin; Tolbutamide | 1994 |
Mg(2+)-dependent inhibition of KATP by sulphonylureas in CRI-G1 insulin-secreting cells.
Topics: Adenosine Triphosphate; Animals; Benzamides; Cell Line; Cell Membrane; Electrophysiology; Glyburide; Hypoglycemic Agents; Islets of Langerhans; Ligands; Magnesium; Potassium Channels; Rats; Sulfonylurea Compounds; Thiopental; Tolbutamide | 1994 |
The ATP-regulated potassium channel in ischemia-reperfusion injury.
Topics: Adenosine Triphosphate; Animals; Dogs; Glyburide; Ion Channel Gating; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Picolines; Potassium Channels; Pyrans; Tolbutamide | 1994 |
Photoaffinity labeling of the cerebral sulfonylurea receptor using a novel radioiodinated azidoglibenclamide analogue.
Topics: Affinity Labels; Animals; ATP-Binding Cassette Transporters; Binding, Competitive; Cell Fractionation; Cerebral Cortex; Electrophoresis, Polyacrylamide Gel; Glipizide; Glyburide; Iodine Radioisotopes; Kinetics; Microsomes; Molecular Weight; Photolysis; Potassium Channels; Potassium Channels, Inwardly Rectifying; Radioligand Assay; Receptors, Drug; Sulfonylurea Receptors; Swine; Tolbutamide; Tritium | 1994 |
The effects of trypsin on ATP-sensitive potassium channel properties and sulfonylurea receptors in the CRI-G1 insulin-secreting cell line.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Cell Line; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Potentials; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Sulfonylurea Receptors; Tolbutamide; Trypsin | 1994 |
Comparative placental transport of oral hypoglycemic agents in humans: a model of human placental drug transfer.
Topics: Administration, Oral; Analysis of Variance; Antipyrine; Biological Transport; Chlorpropamide; Chromatography, High Pressure Liquid; Female; Glipizide; Glyburide; Humans; Hypoglycemic Agents; Maternal-Fetal Exchange; Models, Biological; Molecular Weight; Placenta; Pregnancy; Regression Analysis; Tolbutamide | 1994 |
Tolbutamide suppresses anoxic outward current of hippocampal neurons.
Topics: Adenosine Triphosphate; Animals; Glyburide; Hippocampus; Hypoxia, Brain; In Vitro Techniques; Kynurenic Acid; Neurons; Potassium Channels; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Tetrodotoxin; Tolbutamide | 1993 |
Effects of sulphonylureas on cAMP-stimulated Cl- transport via the cystic fibrosis gene product in human epithelial cells.
Topics: Adenosine Triphosphate; Blood Proteins; Cell Line; Chloride Channels; Colforsin; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Diazoxide; Electrophysiology; Glyburide; Humans; Sulfonylurea Compounds; Tolbutamide | 1994 |
Tolbutamide, but not glyburide, affects the excitability and contractility of unfatigued frog sartorius muscle.
Topics: Action Potentials; Animals; Electric Stimulation; Glyburide; Hydrogen-Ion Concentration; Muscle Contraction; Muscle, Smooth; Potassium Channels; Rana pipiens; Tolbutamide | 1993 |
Sulfonylurea-binding sites and ATP-sensitive K+ channels in alpha-TC glucagonoma and beta-TC insulinoma cells.
Topics: Adenosine Triphosphate; Animals; Binding Sites; Binding, Competitive; Diazoxide; Glucagon; Glucagonoma; Glyburide; Insulinoma; Kinetics; Membrane Potentials; Mice; Pancreatic Neoplasms; Potassium Channels; Tolbutamide; Tritium; Tumor Cells, Cultured | 1993 |
Multiple sulfonylurea-sensitive potassium channels: a novel subtype modulated by dopamine.
Topics: Animals; Dopamine; Glyburide; In Vitro Techniques; Male; Membrane Potentials; Neostriatum; Neurons; Potassium Channels; Rats; Rats, Sprague-Dawley; Tolbutamide | 1993 |
Whole-cell recordings of inwardly rectifying K+ currents activated by 5-HT1A receptors on dorsal raphe neurones of the adult rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Barium; Cyclic AMP; Electrophysiology; Glyburide; In Vitro Techniques; Ion Channel Gating; Masoprocol; Membrane Potentials; Neurons; Pertussis Toxin; Potassium; Potassium Channels; Raphe Nuclei; Rats; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Spiperone; Tolbutamide; Virulence Factors, Bordetella | 1993 |
Characterization and solubilization of the sulphonylurea receptor in rat brain.
Topics: Adenine Nucleotides; Adenosine Triphosphatases; Animals; ATP-Binding Cassette Transporters; Benzamides; Binding, Competitive; Brain Chemistry; Ca(2+) Mg(2+)-ATPase; Diazoxide; Glyburide; Guanine Nucleotides; Hypoglycemic Agents; In Vitro Techniques; Membranes; Microsomes; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Sulfonylurea Receptors; Tolbutamide | 1993 |
Sulphonylurea drugs no longer inhibit ATP-sensitive K+ channels during metabolic stress in cardiac muscle.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cells, Cultured; Dihydropyridines; Dinitrophenols; Glyburide; Heart; Membrane Potentials; Myocardial Contraction; Myocardium; Potassium Channels; Rats; Sensitivity and Specificity; Stress, Physiological; Sulfonylurea Compounds; Tolbutamide | 1993 |
Effects of potassium channel openers and their antagonists on rat locus coeruleus neurones.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Barium; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; In Vitro Techniques; Kynurenic Acid; Locus Coeruleus; Male; Membrane Potentials; Neurons; Parasympatholytics; Potassium Channels; Pyridines; Pyrroles; Rats; Rats, Wistar; Substantia Nigra; Tetrodotoxin; Tolbutamide | 1993 |
Potassium channel-mediated relaxation to acetylcholine in rabbit arteries.
Topics: Acetylcholine; Animals; Aorta, Abdominal; Aorta, Thoracic; Arginine; Cyclic GMP; Endothelium, Vascular; Glyburide; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Potassium; Potassium Channels; Rabbits; Stimulation, Chemical; Tetraethylammonium; Tetraethylammonium Compounds; Tolbutamide | 1993 |
Adenosine release is a major cause of failure of synaptic transmission during hypoglycaemia in rat hippocampal slices.
Topics: Action Potentials; Adenosine; Animals; Caffeine; Cell Hypoxia; Energy Metabolism; Evoked Potentials; Glucose; Glyburide; Hippocampus; Hypoglycemia; Neural Inhibition; Potassium; Potassium Channels; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Theophylline; Tolbutamide | 1993 |
Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Carbachol; Cytoplasm; Diazoxide; DNA, Neoplasm; Eflornithine; Glucose; Glyburide; Inositol Phosphates; Insulin; Insulin Secretion; Insulinoma; Kinetics; Pancreatic Neoplasms; Polyamines; Potassium; Putrescine; Rats; RNA, Messenger; Spermidine; Spermine; Tetradecanoylphorbol Acetate; Theophylline; Tolbutamide; Tumor Cells, Cultured | 1993 |
Sulphonylureas reduce the slowly inactivating D-type outward current in rat hippocampal neurons.
Topics: Adenosine Triphosphate; Animals; Electric Conductivity; Glyburide; Hippocampus; Hypoglycemic Agents; In Vitro Techniques; Male; Membrane Potentials; Neurons; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Sulfonylurea Compounds; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin; Tolbutamide | 1993 |
ATP-inhibited and Ca(2+)-dependent K+ channels in the soma membrane of cultured leech Retzius neurons.
Topics: Adenosine Triphosphate; Animals; Barium; Calcium; Cells, Cultured; Cesium; Electric Stimulation; Glyburide; Hydrogen-Ion Concentration; Leeches; Membrane Potentials; Neurons; Potassium Channels; Tetraethylammonium; Tetraethylammonium Compounds; Tolbutamide | 1993 |
Tolbutamide-sensitive potassium conductance in the basolateral membrane of A6 cells.
Topics: Adenosine Triphosphate; Amphibians; Animals; Cell Line; Cell Membrane; Epithelium; Glucose; Glyburide; Insulin; Kidney; Membrane Potentials; Potassium Channels; Sulfonylurea Compounds; Tolbutamide | 1993 |
Potentiating effects of combined usage of three sulfonylurea drugs on the occurrence of alloxan diabetes in rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Combinations; Drug Synergism; Gliclazide; Glyburide; Hypoglycemic Agents; Rats; Rats, Wistar; Sulfonylurea Compounds; Tolbutamide | 1993 |
Mechanosensitive gating of atrial ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Animals; Electrophysiology; Glyburide; Guanidines; Heart Atria; Ion Channel Gating; Myocardium; Pinacidil; Potassium Channels; Pressure; Rats; Rats, Wistar; Tolbutamide | 1993 |
Glibenclamide and meglitinide block the transport of low molecular weight solutes into malaria-infected erythrocytes.
Topics: Animals; Benzamides; Biological Transport; Cells, Cultured; Chlorides; Choline; Erythrocytes; Glyburide; Humans; Kinetics; Molecular Weight; Plasmodium falciparum; Sorbitol; Threonine; Tolbutamide | 1993 |
PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells.
Topics: Animals; Calcium; Cells, Cultured; Cytoplasmic Granules; Electric Conductivity; Exocytosis; Glipizide; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Potentials; Mice; Patch-Clamp Techniques; Protein Kinase C; Sulfonylurea Compounds; Tolbutamide | 1996 |
Gliclazide hydroxylation by rat liver microsomes.
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Gliclazide; Glipizide; Glyburide; Hydroxylation; Hypoglycemic Agents; Kinetics; Male; Microsomes, Liver; Mixed Function Oxygenases; Rats; Rats, Sprague-Dawley; Tolbutamide | 1995 |
Tolbutamide blocks Ca(2+)- and voltage-dependent K+ currents of hippocampal Ca1 neurons.
Topics: Animals; Calcium Channels; Depression, Chemical; Dose-Response Relationship, Drug; Evoked Potentials; Glyburide; Hippocampus; In Vitro Techniques; Membrane Potentials; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley; Tolbutamide | 1996 |
ATP-sensitive K+ channels are functional in expiratory neurones of normoxic cats.
Topics: Adenosine Triphosphate; Animals; Bicuculline; Blood-Brain Barrier; Brain Stem; Cats; Female; Glyburide; Hypoxia; Male; Membrane Potentials; Neurons; Phrenic Nerve; Potassium Channels; Reference Values; Respiration; Tolbutamide | 1996 |
Sulphonylureas do not increase insulin secretion by a mechanism other than a rise in cytoplasmic Ca2+ in pancreatic B-cells.
Topics: Adenosine Triphosphate; Animals; Calcium; Cytoplasm; Cytosol; Female; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Potassium; Sulfonylurea Compounds; Tolbutamide; Type C Phospholipases | 1996 |
Membrane potentials and microenvironment of rat dorsal vagal cells in vitro during energy depletion.
Topics: Animals; Brain Stem; Cell Hypoxia; Diazoxide; Electric Stimulation; Glucose; Glyburide; Hydrogen-Ion Concentration; In Vitro Techniques; Membrane Potentials; Neuroglia; Neurons; Oxygen Consumption; Potassium; Rats; Synaptic Transmission; Tolbutamide; Vagus Nerve | 1996 |
Photohemolytic potency of oral antidiabetic drugs in vitro: effects of antioxidants and a nitrogen atmosphere.
Topics: Antioxidants; Ascorbic Acid; Carbutamide; Chlorpropamide; Dose-Response Relationship, Drug; Gliclazide; Glipizide; Glyburide; Hemolysis; Humans; Hypoglycemic Agents; Nitrogen; Radiation-Sensitizing Agents; Reactive Oxygen Species; Sulfonamides; Sulfonylurea Compounds; Superoxide Dismutase; Tolazamide; Tolbutamide; Ultraviolet Rays; Vitamin E | 1996 |
Inhibitory effect of sulfonylureas on protein phosphatase activity in rat pancreatic islets.
Topics: Animals; Cytosol; Gliclazide; Glyburide; Hypoglycemic Agents; Islets of Langerhans; Kinetics; Male; Okadaic Acid; Phosphoprotein Phosphatases; Rats; Rats, Wistar; Sulfonylurea Compounds; Tolbutamide | 1997 |
Rates of hypoglycemia in users of sulfonylureas.
Topics: Adult; Aged; Chlorpropamide; Female; Gliclazide; Glipizide; Glyburide; Humans; Hypoglycemia; Hypoglycemic Agents; Incidence; Male; Middle Aged; Poisson Distribution; Risk; Risk Factors; Sulfonylurea Compounds; Surveys and Questionnaires; Time Factors; Tolbutamide | 1997 |
Antidiabetic sulphonylureas stimulate acetylcholine release from striatal cholinergic interneurones through inhibition of K(ATP) channel activity.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Corpus Striatum; Glyburide; Hypoglycemic Agents; Interneurons; Male; Parasympathetic Nervous System; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Tolbutamide | 1997 |
Ca2+-activated K+ currents in rat locus coeruleus neurons induced by experimental ischemia, anoxia, and hypoglycemia.
Topics: Animals; Brain Ischemia; Calcium; Calcium Channels; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Charybdotoxin; Glucose; Glyburide; Hypoglycemia; Hypoxia, Brain; In Vitro Techniques; Locus Coeruleus; Membrane Potentials; N-Methylaspartate; Neurons; Oxygen; Partial Pressure; Rats; Rats, Wistar; Ryanodine; Sodium Cyanide; Thapsigargin; Tolbutamide | 1997 |
KATP channels contribute to beta- and adenosine receptor-mediated pulmonary vasorelaxation.
Topics: Acetylcholine; Adenosine; Adenylyl Cyclases; Animals; ATP-Binding Cassette Transporters; Colforsin; Cromakalim; Cyclic AMP; Cyclic GMP; Glyburide; In Vitro Techniques; Isoproterenol; KATP Channels; Kinetics; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Purinergic P1; Tolbutamide; Vasodilation | 1997 |
Effects of glycosylation of hypoglycaemic drug binding to serum albumin.
Topics: Acetohexamide; Binding Sites; Binding, Competitive; Gliclazide; Glyburide; Glycated Serum Albumin; Glycation End Products, Advanced; Glycosylation; Humans; Hypoglycemic Agents; Metformin; Serum Albumin; Spectrometry, Fluorescence; Structure-Activity Relationship; Tolbutamide | 1997 |
The effects of gliclazide and other sulfonylureas on low-density lipoprotein oxidation in vitro.
Topics: Administration, Oral; Adult; Antioxidants; Ascorbic Acid; Coronary Artery Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Gliclazide; Glipizide; Glyburide; Humans; Hypoglycemic Agents; Lipoproteins, LDL; Male; Middle Aged; Oxidation-Reduction; Sulfonylurea Compounds; Tolbutamide | 1997 |
Treatment of NIDDM in youth.
Topics: Adolescent; Child; Diabetes Mellitus, Type 2; Female; Glyburide; Humans; Hypoglycemic Agents; Japan; Male; School Health Services; Tolbutamide | 1998 |
Whole cell patch-clamp recordings of rat midbrain dopaminergic neurons isolate a sulphonylurea- and ATP-sensitive component of potassium currents activated by hypoxia.
Topics: Adenosine Triphosphate; Animals; Barium Compounds; Cell Hypoxia; Charybdotoxin; Chlorides; Dopamine; Glipizide; Glyburide; In Vitro Techniques; Membrane Potentials; Mesencephalon; Microelectrodes; Neurons; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Wistar; Reaction Time; Sulfonylurea Compounds; Tolbutamide | 1998 |
Insulin secretion from isolated rat islets induced by the novel hypoglycemic agent A-4166, a derivative of D-phenylalanine.
Topics: Animals; ATP-Binding Cassette Transporters; Biological Availability; Calcium; Cell Line; Cyclohexanes; Diazoxide; Epinephrine; Glucose; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Male; Nateglinide; Phenylalanine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Drug; Rubidium; Somatostatin; Stereoisomerism; Sulfonylurea Receptors; Tolbutamide | 1998 |
Hypoxia activates ATP-dependent potassium channels in inspiratory neurones of neonatal mice.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Calcium; Diazoxide; Electric Stimulation; Glyburide; Hypoglycemic Agents; Hypoxia; Hypoxia, Brain; Ion Channel Gating; Medulla Oblongata; Membrane Potentials; Mice; Neurons; Patch-Clamp Techniques; Potassium Channels; Respiration; Tolbutamide; Vasodilator Agents | 1998 |
Identification of an ATP-sensitive potassium channel current in rat striatal cholinergic interneurones.
Topics: Adenosine Triphosphate; Animals; Diazoxide; Diuretics; Electric Stimulation; Electrophysiology; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Interneurons; Male; Membrane Potentials; Neostriatum; Parasympathetic Nervous System; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Sodium Chloride Symporter Inhibitors; Tolbutamide | 1998 |
Tissue specificity of sulfonylureas: studies on cloned cardiac and beta-cell K(ATP) channels.
Topics: Animals; ATP-Binding Cassette Transporters; Benzamides; Cloning, Molecular; Female; Glyburide; Heart; Hypoglycemic Agents; Islets of Langerhans; Membrane Potentials; Mice; Myocardium; Oocytes; Organ Specificity; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Recombinant Proteins; Sulfonylurea Receptors; Tolbutamide; Xenopus laevis | 1998 |
Sulfonylureas enhance exocytosis from pancreatic beta-cells by a mechanism that does not involve direct activation of protein kinase C.
Topics: Animals; Calcium; Enzyme Activation; Exocytosis; Glyburide; Guanosine 5'-O-(3-Thiotriphosphate); Hypoglycemic Agents; Insulinoma; Islets of Langerhans; Isoenzymes; Mice; Pancreatic Neoplasms; Phosphatidylserines; Potassium Channels; Protein Kinase C; Sulfonylurea Compounds; Tetradecanoylphorbol Acetate; Tolbutamide; Tumor Cells, Cultured | 1998 |
Reconstituted human cardiac KATP channels: functional identity with the native channels from the sarcolemma of human ventricular cells.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adolescent; Adult; Animals; ATP-Binding Cassette Transporters; Child; CHO Cells; Cloning, Molecular; COS Cells; Cricetinae; Cromakalim; Diazoxide; DNA, Complementary; Gene Library; Glyburide; Heart Ventricles; Humans; Magnesium; Middle Aged; Myocardium; Patch-Clamp Techniques; Pinacidil; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Sarcolemma; Sulfonylurea Receptors; Tolbutamide; Transfection | 1998 |
Effects of sulphonylureas on the volume-sensitive anion channel in rat pancreatic beta-cells.
Topics: Animals; Anions; Benzamides; Cells, Cultured; Dose-Response Relationship, Drug; Evoked Potentials; Glyburide; Hypoglycemic Agents; Ion Channels; Ion Transport; Islets of Langerhans; Rats; Sulfonylurea Compounds; Taurine; Tolbutamide | 1998 |
Sodium influx plays a major role in the membrane depolarization induced by oxygen and glucose deprivation in rat striatal spiny neurons.
Topics: Adenosine Triphosphate; Animals; Brain Ischemia; Calcium; Calcium Channel Blockers; Calcium Channels; Cerebral Cortex; Chelating Agents; Corpus Striatum; Egtazic Acid; Glucose; Glyburide; Hypoglycemic Agents; Magnesium; Membrane Potentials; Neurons; Organ Culture Techniques; Oxygen; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Receptors, Glutamate; Sodium; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Tolbutamide | 1999 |
Sulfonylureas stimulate renin secretion from the perfused kidney of the rat.
Topics: Animals; Blood Pressure; Chlorpropamide; Cyclic AMP; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Kidney; Male; Perfusion; Rats; Rats, Wistar; Renin; Stimulation, Chemical; Sulfonylurea Compounds; Tolbutamide | 1999 |
Endothelium-dependent blunted membrane potential responses to ATP-sensitive K+ channel modulators in aortae from rats with cirrhosis.
Topics: Adenosine Triphosphate; Animals; Aorta; Bosentan; Cromakalim; Diazoxide; Endothelin-1; Endothelium, Vascular; Glyburide; Liver Cirrhosis, Experimental; Male; Membrane Potentials; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Sulfonamides; Tolbutamide | 1999 |
JTT-608 controls blood glucose by enhancement of glucose-stimulated insulin secretion in normal and diabetes mellitus rats.
Topics: Administration, Oral; Animals; Animals, Newborn; Blood Glucose; Butyrates; Cyclohexanes; Diabetes Mellitus, Experimental; Fasting; Glucose; Glucose Tolerance Test; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Rats; Rats, Sprague-Dawley; Rats, Wistar; Tolbutamide | 1999 |
Characterization of low-affinity binding sites for glibenclamide on the Kir6.2 subunit of the beta-cell KATP channel.
Topics: Animals; ATP-Binding Cassette Transporters; Binding Sites; Blotting, Northern; Cell Line; Cell Membrane; COS Cells; Gliclazide; Glipizide; Glyburide; Islets of Langerhans; Kinetics; Organelles; Phentolamine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Recombinant Fusion Proteins; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide; Transfection | 1999 |
Glucose regulation of insulin secretion independent of the opening or closure of adenosine triphosphate-sensitive K+ channels in beta cells.
Topics: Adenosine Triphosphate; Animals; Calcium; Diazoxide; Exocytosis; Female; Glucose; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Ion Channel Gating; Islets of Langerhans; Mice; Potassium Channels; Sulfonylurea Compounds; Tolbutamide | 1999 |
The stimulatory action of tolbutamide on Ca2+-dependent exocytosis in pancreatic beta cells is mediated by a 65-kDa mdr-like P-glycoprotein.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Calcium; Cells, Cultured; Cytoplasmic Granules; Diabetes Mellitus, Type 2; Drug Resistance, Multiple; Exocytosis; Glyburide; Islets of Langerhans; Mice; Mice, Inbred Strains; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors; Tolbutamide | 1999 |
A role for KATP+-channels in mediating the elevations of cerebral blood flow and arterial pressure by hypoxic stimulation of oxygen-sensitive neurons of rostral ventrolateral medulla.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Brain Chemistry; Cerebrovascular Circulation; Glyburide; Hypoglycemic Agents; Hypoxia; Hypoxia, Brain; Male; Medulla Oblongata; Neurons; Oxygen; Potassium Channels; Rats; Rats, Sprague-Dawley; Respiratory Center; Tolbutamide | 1999 |
The effect of an insulin releasing agent, BTS 67582, on advanced glycation end product formation in vitro.
Topics: Ferrous Compounds; Glucose; Glucose-6-Phosphate; Glyburide; Glycation End Products, Advanced; Guanidines; Lysine; Serum Albumin, Bovine; Tolbutamide | 1999 |
Identification of the high-affinity tolbutamide site on the SUR1 subunit of the K(ATP) channel.
Topics: Adenosine Diphosphate; Amino Acid Substitution; Animals; ATP-Binding Cassette Transporters; Binding Sites; COS Cells; Glyburide; Hypoglycemic Agents; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide; Transfection; Xenopus | 1999 |
Effect of hypoxia on membrane potential and resting conductance in rat hippocampal neurons.
Topics: Adenosine Triphosphate; Animals; Cell Hypoxia; Dantrolene; Dizocilpine Maleate; Electric Conductivity; Glyburide; Hippocampus; Hypoglycemia; In Vitro Techniques; Membrane Potentials; Potassium Chloride; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Tetrodotoxin; Time Factors; Tolbutamide | 1999 |
Potentiation of quantal catecholamine secretion by glibenclamide: evidence for a novel role of sulphonylurea receptors in regulating the Ca(2+) sensitivity of exocytosis.
Topics: Animals; ATP-Binding Cassette Transporters; Caffeine; Calcium; Catecholamines; Cromakalim; Egtazic Acid; Electrochemistry; Exocytosis; Glyburide; Kinetics; Membrane Potentials; Patch-Clamp Techniques; PC12 Cells; Pinacidil; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Quantum Theory; Rats; Receptors, Drug; Sulfonylurea Receptors; Tolbutamide | 1999 |
Alterations of insulin secretion from mouse islets treated with sulphonylureas: perturbations of Ca2+ regulation prevail over changes in insulin content.
Topics: Adenosine Triphosphate; Animals; Calcium; Cells, Cultured; Glucose; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Potassium Channels; Tolbutamide | 1999 |
Different effects of tolbutamide and diazoxide in alpha, beta-, and delta-cells within intact islets of Langerhans.
Topics: Animals; Boron Compounds; Calcium; Diazoxide; Fluorescent Dyes; Glucose; Glyburide; In Vitro Techniques; Islets of Langerhans; Kinetics; Mice; Mice, Inbred Strains; Potassium Channels; Receptors, Drug; Signal Transduction; Tolbutamide | 1999 |
Involvement of adenosine triphosphate-sensitive K+ channels in glucose-sensing in the rat solitary tract nucleus.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Diazoxide; Glyburide; Homeostasis; Hypoglycemia; Hypoglycemic Agents; Male; Nerve Tissue Proteins; Neurons; Pinacidil; Potassium Channels; Rats; Rats, Wistar; Solitary Nucleus; Tolbutamide | 2000 |
Pharmacological identification of the K(+) currents mediating the hypoglycemic hyperpolarization of rat midbrain dopaminergic neurones.
Topics: Animals; Barium; Charybdotoxin; Dopamine; Extracellular Space; Glucose; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Mesencephalon; Neurons; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Strophanthidin; Tolbutamide | 2000 |
Pharmacology of human sulphonylurea receptor SUR1 and inward rectifier K(+) channel Kir6.2 combination expressed in HEK-293 cells.
Topics: ATP-Binding Cassette Transporters; Binding, Competitive; Cations; Cell Line; Deoxyglucose; Diazoxide; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; Fluorescence; Gene Expression; Glipizide; Glyburide; Humans; Membrane Potentials; Oligomycins; Potassium Channels; Potassium Channels, Inwardly Rectifying; Radioligand Assay; Receptors, Drug; Recombinant Fusion Proteins; RNA, Messenger; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolazamide; Tolbutamide; Tritium | 2000 |
Inhibitory effects of glibenclamide on the contraction of human arterial conduits used in coronary artery bypass surgery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Calcium; Coronary Artery Bypass; Dose-Response Relationship, Drug; Glyburide; Humans; In Vitro Techniques; Indomethacin; Mammary Arteries; Phenylephrine; Potassium; Radial Artery; Tolbutamide; Vasoconstriction; Vasoconstrictor Agents | 2000 |
Glibenclamide but not other sulphonylureas stimulates release of neuropeptide Y from perifused rat islets and hamster insulinoma cells.
Topics: Animals; Blotting, Northern; Cricetinae; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Neuropeptide Y; Pancreatic Neoplasms; Perfusion; Radioimmunoassay; Rats; Stimulation, Chemical; Tolbutamide; Tumor Cells, Cultured | 2000 |
Identification of sulfonylureas in serum by electrospray mass spectrometry.
Topics: Calibration; Chlorpropamide; Chromatography, Liquid; Glipizide; Glyburide; Humans; Mass Spectrometry; Models, Chemical; Sulfonylurea Compounds; Tolbutamide; Ultraviolet Rays | 2000 |
Sensitivity of Kir6.2-SUR1 currents, in the absence and presence of sodium azide, to the K(ATP) channel inhibitors, ciclazindol and englitazone.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Benzopyrans; Cell Line; Dose-Response Relationship, Drug; Female; Glyburide; Humans; Indoles; Membrane Potentials; Mice; Microinjections; Oocytes; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; RNA, Complementary; Sodium Azide; Sulfonylurea Receptors; Thiazoles; Thiazolidinediones; Tolbutamide; Xenopus laevis | 2000 |
Activation of sulphonylurea-sensitive channels and the NO-cGMP pathway decreases the heart rate response to sympathetic nerve stimulation.
Topics: Analysis of Variance; Animals; Cyclic GMP; Diazoxide; Electric Stimulation; Enzyme Inhibitors; Glyburide; Guinea Pigs; Heart Atria; Heart Rate; Hypoxia; In Vitro Techniques; Male; Nitric Oxide; Norepinephrine; Potassium Channel Blockers; Potassium Channels; Stellate Ganglion; Sympathetic Nervous System; Tolbutamide | 2000 |
Sulphonylurea drugs reduce hypoxic damage in the isolated perfused rat kidney.
Topics: Analysis of Variance; Animals; ATP-Binding Cassette Transporters; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Ischemia; KATP Channels; Kidney; Male; Perfusion; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protective Agents; Rats; Rats, Wistar; Tolbutamide | 2000 |
Sulphonylurea-sensitive channels and NO-cGMP pathway modulate the heart rate response to vagal nerve stimulation in vitro.
Topics: Acetylcholine; Animals; Cyclic GMP; Diazoxide; Electric Stimulation; Glyburide; Guinea Pigs; Heart Conduction System; Heart Rate; Ion Transport; Male; Muscle Proteins; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Potassium; Potassium Channels; Signal Transduction; Sulfonylurea Compounds; Tolbutamide; Vagus Nerve | 2000 |
Analysis of single K(ATP) channels in mammalian dentate gyrus granule cells.
Topics: Animals; Antihypertensive Agents; Dentate Gyrus; Diazoxide; Glyburide; Hypoglycemia; Hypoglycemic Agents; Hypoxia; Ion Channel Gating; Kinetics; Male; Mammals; Membrane Potentials; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Tolbutamide | 2000 |
Desensitization of sulphonylurea- and nutrient-induced insulin secretion following prolonged treatment with glibenclamide.
Topics: Adenosine Triphosphate; Alanine; Animals; Arginine; Cell Line; Culture Media; Dose-Response Relationship, Drug; Glucose; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Keto Acids; Potassium Channels; Potassium Chloride; Sulfonylurea Compounds; Tolbutamide | 2000 |
Activation of Na(+), K(+), Cl(-)-cotransport mediates intracellular Ca(2+) increase and apoptosis induced by Pinacidil in HepG2 human hepatoblastoma cells.
Topics: Adenosine Triphosphate; Amiloride; Apoptosis; Bepridil; Bumetanide; Calcium; Carrier Proteins; DNA Fragmentation; Dose-Response Relationship, Drug; Furosemide; Glyburide; Hepatoblastoma; Humans; Pinacidil; Potassium; Potassium Channel Blockers; Potassium Channels; Sodium; Sodium-Calcium Exchanger; Sodium-Potassium-Chloride Symporters; Time Factors; Tolbutamide; Tumor Cells, Cultured | 2001 |
Interaction of sulfonylurea-conjugated polymer with insulinoma cell line of MIN6 and its effect on insulin secretion.
Topics: Acrylic Resins; Animals; Biocompatible Materials; Culture Media, Conditioned; Diazoxide; Glucose; Glyburide; Insulin; Insulin Secretion; Insulinoma; Kinetics; Magnetic Resonance Spectroscopy; Materials Testing; Molecular Structure; Pancreatic Neoplasms; Povidone; Sulfonylurea Compounds; Tolbutamide; Tumor Cells, Cultured | 2001 |
Sulfonylurea receptors inhibit the epithelial sodium channel (ENaC) by reducing surface expression.
Topics: Animals; ATP-Binding Cassette Transporters; Cystic Fibrosis Transmembrane Conductance Regulator; Diazoxide; Diuretics; Epithelial Sodium Channels; Glyburide; Hypoglycemic Agents; Oocytes; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sodium Channel Blockers; Sodium Channels; Sodium Chloride Symporter Inhibitors; Sulfonylurea Receptors; Time Factors; Tolbutamide; Vasodilator Agents; Xenopus laevis | 2001 |
Dibutyryl-cyclic GMP induces peripheral antinociception via activation of ATP-sensitive K(+) channels in the rat PGE2-induced hyperalgesic paw.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Analgesics; Animals; Apamin; Cesium; Charybdotoxin; Dibutyryl Cyclic GMP; Dinoprostone; Dose-Response Relationship, Drug; Glyburide; Hindlimb; Hyperalgesia; Male; Pain; Pain Measurement; Pain Threshold; Potassium Channels; Rats; Rats, Wistar; Tetraethylammonium; Tolbutamide | 2001 |
The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: comparison with the sulfonylureas and nateglinide.
Topics: Animals; ATP-Binding Cassette Transporters; Cell Line; COS Cells; Cyclohexanes; Glyburide; Hypoglycemic Agents; Indoles; Insulin; Isoindoles; Nateglinide; Patch-Clamp Techniques; Phenylalanine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide; Transfection | 2001 |
Novel properties of peptides derived from the sequence coded by exon 26A of human elastin.
Topics: 4-Aminopyridine; Animals; Aorta; Dose-Response Relationship, Drug; Elastin; Enzyme Inhibitors; Exons; Glyburide; Humans; Hypoglycemic Agents; In Vitro Techniques; Lactose; Male; Models, Biological; Muscle, Smooth, Vascular; Nitroarginine; Peptides; Phenylephrine; Potassium Channel Blockers; Rats; Rats, Wistar; Tolbutamide; Vasoconstrictor Agents; Virulence Factors, Bordetella | 2002 |
Pharmacological evidence for the activation of K(+) channels by diclofenac.
Topics: 4-Aminopyridine; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apamin; Behavior, Animal; Charybdotoxin; Diclofenac; Dose-Response Relationship, Drug; Female; Formaldehyde; Glyburide; Hindlimb; Morphine; Pain; Pinacidil; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Tetraethylammonium; Tolbutamide | 2002 |
Involvement of ATP-sensitive K(+) channels in the peripheral antinociceptive effect induced by dipyrone.
Topics: Adenosine Triphosphate; Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Drug Interactions; Glyburide; Male; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Tolbutamide | 2002 |
A novel simple method for the investigation of drug binding to the K(ATP) channel sulfonylurea receptor.
Topics: Animals; ATP-Binding Cassette Transporters; Carbamates; Gliclazide; Glyburide; Hypoglycemic Agents; Kinetics; Piperidines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Binding; Rats; Receptors, Drug; Spodoptera; Sulfonylurea Receptors; Tolbutamide | 2002 |
The molecular site of action of K(ATP) channel inhibitors determines their ability to inhibit iNOS-mediated relaxation in rat aorta.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Aminopyridines; Analysis of Variance; Animals; Aorta; Arginine; Barium; Endothelium, Vascular; Glyburide; Guanidines; Lipopolysaccharides; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Tolbutamide; Vasodilator Agents | 2002 |
The peripheral antinociceptive effect of resveratrol is associated with activation of potassium channels.
Topics: 4-Aminopyridine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apamin; ATP-Binding Cassette Transporters; Charybdotoxin; Female; Glipizide; Glyburide; KATP Channels; Morphine; Narcotics; Peripheral Nervous System; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Calcium-Activated; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Resveratrol; Stilbenes; Tetraethylammonium; Tolbutamide | 2002 |
The cytoplasmic C-terminus of the sulfonylurea receptor is important for KATP channel function but is not key for complex assembly or trafficking.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Biotinylation; Cell Line; Cell Membrane; Cricetinae; Diazoxide; Fluorescent Antibody Technique; Glyburide; Humans; Kidney; Macromolecular Substances; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Binding; Protein Structure, Tertiary; Protein Transport; Receptors, Drug; Sequence Deletion; Structure-Activity Relationship; Sulfonylurea Receptors; Tolbutamide | 2002 |
Role of the nitric oxide-cyclic GMP-K+ channel pathway in the antinociception induced by atrial natriuretic peptide (ANP) and diclofenac.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Atrial Natriuretic Factor; Charybdotoxin; Cyclic GMP; Diclofenac; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Formaldehyde; Glyburide; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Pain Measurement; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; Tolbutamide | 2002 |
Possible involvement of potassium channels in peripheral antinociception induced by metamizol: lack of participation of ATP-sensitive K+ channels.
Topics: 4-Aminopyridine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apamin; Area Under Curve; ATP-Binding Cassette Transporters; Charybdotoxin; Dipyrone; Drug Interactions; Female; Formaldehyde; Glyburide; KATP Channels; Pain Measurement; Peripheral Nerves; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Tetraethylammonium; Tolbutamide | 2003 |
Dimethyl disulfide exerts insecticidal neurotoxicity through mitochondrial dysfunction and activation of insect K(ATP) channels.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Axons; Coleoptera; Disulfides; Electron Transport Complex IV; Electrophysiology; Fumigation; Glyburide; Insecticides; Male; Mice; Mitochondria; Neurons; Neurotoxins; Patch-Clamp Techniques; Periplaneta; Potassium Channel Blockers; Potassium Channels; Synaptic Transmission; Tolbutamide | 2003 |
Functional coupling between sulfonylurea receptor type 1 and a nonselective cation channel in reactive astrocytes from adult rat brain.
Topics: Adenosine Triphosphate; Animals; Antibodies; Astrocytes; ATP-Binding Cassette Transporters; Binding, Competitive; Brain; Brain Injuries; Cell Size; Cells, Cultured; Diazoxide; Gliosis; Glyburide; Ion Channels; Membrane Potentials; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; Sodium Azide; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide; Trypsin | 2003 |
Sulfonylureas rapidly cross phospholipid bilayer membranes by a free-diffusion mechanism.
Topics: Albumins; Diffusion; Fluoresceins; Fluorescence; Fluorescent Dyes; Fluorometry; Glyburide; Hydrogen-Ion Concentration; Lipid Bilayers; Magnetic Resonance Spectroscopy; Phospholipids; Sulfonylurea Compounds; Time Factors; Titrimetry; Tolbutamide | 2003 |
Diclofenac-induced peripheral antinociception is associated with ATP-sensitive K+ channels activation.
Topics: Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Hyperalgesia; Indomethacin; Male; Naloxone; Narcotic Antagonists; Pain Measurement; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Tolbutamide | 2004 |
Chronic exposure to tolbutamide and glibenclamide impairs insulin secretion but not transcription of K(ATP) channel components.
Topics: Animals; ATP-Binding Cassette Transporters; Cells, Cultured; Clone Cells; Gene Expression Regulation; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Multidrug Resistance-Associated Proteins; Pancreas; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide | 2004 |
Study of the involvement of K+ channels in the peripheral antinociception of the kappa-opioid receptor agonist bremazocine.
Topics: 4-Aminopyridine; Analgesics; Animals; ATP-Binding Cassette Transporters; Benzomorphans; Charybdotoxin; Cyclic GMP; Dequalinium; Glyburide; Hyperalgesia; KATP Channels; Male; Naltrexone; Nitric Oxide; Peripheral Nervous System; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Receptors, Opioid, kappa; Signal Transduction; Tetraethylammonium; Tolbutamide | 2004 |
Taurine block of cloned ATP-sensitive K+ channels with different sulfonylurea receptor subunits expressed in Xenopus laevis oocytes.
Topics: Animals; ATP-Binding Cassette Transporters; Carbamates; Drug Interactions; Female; Gene Expression; Gliclazide; Glyburide; Hypoglycemic Agents; Membrane Proteins; Mice; Oocytes; Piperidines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Subunits; Rats; Receptors, Drug; Sulfonylurea Receptors; Taurine; Tolbutamide; Xenopus laevis | 2004 |
Testosterone modulates K(+)ATP channels in Sertoli cell membrane via the PLC-PIP2 pathway.
Topics: Adenosine Triphosphate; Androgens; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Electric Impedance; Glyburide; Male; Membrane Potentials; Membrane Proteins; Pertussis Toxin; Phosphatidylinositol 4,5-Diphosphate; Potassium Channels; Rats; Rats, Wistar; Sertoli Cells; Static Electricity; Testosterone; Tolbutamide; Type C Phospholipases | 2004 |
Pharmacological evidence for the activation of Ca2+-activated K+ channels by meloxicam in the formalin test.
Topics: 4-Aminopyridine; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Apamin; Behavior, Animal; Charybdotoxin; Dose-Response Relationship, Drug; Female; Formaldehyde; Glyburide; Meloxicam; Pain; Pain Measurement; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Tetraethylammonium; Thiazines; Thiazoles; Tolbutamide | 2005 |
ATP and sulfonylurea sensitivity of mutant ATP-sensitive K+ channels in neonatal diabetes: implications for pharmacogenomic therapy.
Topics: Adenosine Triphosphate; Animals; Cell Line; Diabetes Mellitus, Type 1; Glyburide; Humans; Hypoglycemic Agents; Mutation; Pharmacogenetics; Potassium Channels, Inwardly Rectifying; Tolbutamide | 2005 |
Partial mitochondrial inhibition causes striatal dopamine release suppression and medium spiny neuron depolarization via H2O2 elevation, not ATP depletion.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Catalase; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Fluoresceins; Glyburide; Guinea Pigs; Hydrogen Peroxide; Hypoglycemic Agents; In Vitro Techniques; Membrane Potentials; Neurons; Patch-Clamp Techniques; Rotenone; Sodium Channel Blockers; Tetrodotoxin; Time Factors; Tolbutamide; Uncoupling Agents | 2005 |
Inhibition of 1-methyl-4-phenylpyridinium-induced mitochondrial dysfunction and cell death in PC12 cells by sulfonylurea glibenclamide.
Topics: 1-Methyl-4-phenylpyridinium; Acetylcysteine; Animals; Apoptosis; Benzoates; Caspase 3; Caspases; Catalase; Cell Nucleus; Cell Survival; Cytochromes c; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; Glutathione; Glyburide; Imidazoles; Mitochondrial Membranes; PC12 Cells; Permeability; Porphyrins; Rats; Reactive Oxygen Species; Tolbutamide | 2005 |
KATP channels in mouse spermatogenic cells and sperm, and their role in capacitation.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Barium; Diazoxide; Dose-Response Relationship, Drug; Glyburide; KATP Channels; Male; Membrane Potentials; Mice; Microscopy, Confocal; Multidrug Resistance-Associated Proteins; Pinacidil; Potassium Channels, Inwardly Rectifying; Receptors, Drug; RNA, Messenger; Sperm Capacitation; Spermatogenesis; Spermatozoa; Sulfonylurea Receptors; Time Factors; Tolbutamide | 2006 |
Probable activation of the opioid receptor-nitric oxide-cyclic GMP-K+ channels pathway by codeine.
Topics: 4-Aminopyridine; Analgesics, Opioid; Animals; Codeine; Cyclic GMP; Female; Glyburide; Methylene Blue; Naloxone; NG-Nitroarginine Methyl Ester; Nitric Oxide; Potassium Channels; Rats; Rats, Wistar; Receptors, Opioid; Tetraethylammonium; Tolbutamide | 2005 |
Hybrid assemblies of ATP-sensitive K+ channels determine their muscle-type-dependent biophysical and pharmacological properties.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; ATP-Binding Cassette Transporters; Biophysics; Cromakalim; Diazoxide; DNA Primers; Dose-Response Relationship, Drug; Gene Expression Regulation; Glyburide; Hypoglycemic Agents; KATP Channels; Kinetics; Male; Models, Statistical; Muscle Fibers, Skeletal; Muscle, Skeletal; Muscles; Patch-Clamp Techniques; Phenotype; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Receptors, Drug; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sulfonylurea Receptors; Tolbutamide | 2006 |
Possible activation of the NO-cyclic GMP-protein kinase G-K+ channels pathway by gabapentin on the formalin test.
Topics: 4-Aminopyridine; Amines; Analgesics; Animals; Apamin; Carbazoles; Charybdotoxin; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamma-Aminobutyric Acid; Glyburide; Indoles; Naloxone; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain Measurement; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Tolbutamide | 2006 |
Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations.
Topics: ATP-Binding Cassette Transporters; Cohort Studies; Diabetes Mellitus; Female; Glyburide; Glycated Hemoglobin; Heterozygote; Humans; Hypoglycemic Agents; Infant; Infant, Newborn; Insulin; Insulin-Secreting Cells; Male; Mutation; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide | 2006 |
First phase of glucose-stimulated insulin secretion from MIN 6 cells does not always require extracellular calcium influx.
Topics: Animals; Calcium; Calcium Isotopes; Cell Line, Tumor; Cell Survival; Dantrolene; Diazoxide; Dose-Response Relationship, Drug; Extracellular Fluid; Glucose; Glyburide; Insulin; Insulin Antagonists; Insulin Secretion; Insulin-Secreting Cells; L-Lactate Dehydrogenase; Male; Mice; Potassium Channels; Sodium Channels; Tetrodotoxin; Tolbutamide; Verapamil | 2006 |
Peripheral antinociceptive effect of pertussis toxin: activation of the arginine/NO/cGMP/PKG/ ATP-sensitive K channel pathway.
Topics: Adenosine Triphosphate; Analgesia; Analgesics; Animals; Arginine; Bucladesine; Carbazoles; Cells, Cultured; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dinoprostone; Enzyme Inhibitors; Ganglia, Spinal; Glyburide; Indoles; KATP Channels; Male; Neurons; Nitric Oxide; omega-N-Methylarginine; Oxadiazoles; Pain; Pain Measurement; Pertussis Toxin; Potassium Channels, Inwardly Rectifying; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Tolbutamide | 2006 |
Baclofen, an agonist at peripheral GABAB receptors, induces antinociception via activation of TEA-sensitive potassium channels.
Topics: Analgesics; Animals; Baclofen; Bicuculline; Cesium; Charybdotoxin; Dequalinium; GABA Agonists; GABA-B Receptor Agonists; Glyburide; Male; Potassium Channels; Rats; Rats, Wistar; Tetraethylammonium; Tolbutamide | 2006 |
Investigation of the effects of sulfonylurea exposure on pancreatic beta cell metabolism.
Topics: Animals; Carbon Radioisotopes; Cells, Cultured; Glucose; Glyburide; Hypoglycemic Agents; Insulin-Secreting Cells; Magnetic Resonance Spectroscopy; Models, Biological; Rats; Sulfonylurea Compounds; Tolbutamide | 2006 |
Transgenic expression of a dominant negative K(ATP) channel subunit in the mouse endothelium: effects on coronary flow and endothelin-1 secretion.
Topics: Adenosine Triphosphate; Animals; Bradykinin; Coronary Circulation; Diazoxide; Electrocardiography; Endothelin-1; Endothelium, Vascular; Ergonovine; Exocytosis; Gene Expression Regulation; Genes, Synthetic; Glyburide; KATP Channels; Mice; Mice, Transgenic; Point Mutation; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Pressure; Rats; Rats, Sprague-Dawley; Tolbutamide; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2007 |
Regulation by glucose of oscillatory electrical activity and 5-HT/insulin release from single mouse pancreatic islets in absence of functional K(ATP) channels.
Topics: Adenosine Triphosphate; Animals; Calcium; Cells, Cultured; Glucose; Glyburide; Insulin; Insulin Secretion; Insulin-Secreting Cells; Keto Acids; Membrane Potentials; Mice; Patch-Clamp Techniques; Potassium Channels; Serotonin; Tolbutamide | 2008 |
The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blood Glucose; Carrier Proteins; Cell Line; Chlorocebus aethiops; COS Cells; Cyclic AMP; Fluorescence Resonance Energy Transfer; Glucose; Glyburide; Guanine Nucleotide Exchange Factors; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Inbred C57BL; rap1 GTP-Binding Proteins; Sulfonylurea Compounds; Tolbutamide | 2009 |
Adenosine inhibits paraventricular pre-sympathetic neurons through ATP-dependent potassium channels.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Adenosine; Analgesics; Animals; Bicuculline; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glyburide; Guanosine Diphosphate; In Vitro Techniques; KATP Channels; Male; Membrane Potentials; Neurons; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A1; Sodium Channel Blockers; Tetrodotoxin; Thionucleotides; Tolbutamide; Triazines; Triazoles; Xanthines | 2010 |
Effects of K openers on the QT prolongation induced by HERG-blocking drugs in guinea-pigs.
Topics: Animals; Benzothiadiazines; Cromakalim; Decanoic Acids; Ether-A-Go-Go Potassium Channels; Glyburide; Guinea Pigs; Heart; Humans; Hydroxy Acids; Intracellular Membranes; KATP Channels; Long QT Syndrome; Male; Membrane Transport Modulators; Mitochondrial Membranes; Picolines; Pinacidil; Potassium Channel Blockers; Pyrans; Sarcolemma; Tolbutamide | 2010 |
Effects of metformin on BRIN-BD11 beta-cell insulin secretory desensitization induced by prolonged exposure to sulphonylureas.
Topics: Cell Line; Culture Media; Glyburide; Humans; Insulin-Secreting Cells; Metformin; Sulfonylurea Compounds; Tolbutamide | 2010 |
Exchange protein directly activated by cyclic AMP isoform 2 is not a direct target of sulfonylurea drugs.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blood Glucose; Carrier Proteins; Cell Line; Chlorocebus aethiops; COS Cells; Cyclic AMP; Fluorescence Resonance Energy Transfer; Glucose; Glyburide; Guanine Nucleotide Exchange Factors; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Inbred C57BL; rap1 GTP-Binding Proteins; Sulfonylurea Compounds; Tolbutamide | 2011 |
Comparable long-term mortality risk associated with individual sulfonylureas in diabetes patients with heart failure.
Topics: Aged; Aged, 80 and over; Diabetes Mellitus; Female; Glipizide; Glyburide; Heart Failure; Humans; Hypoglycemic Agents; Male; Sulfonylurea Compounds; Tolbutamide | 2011 |
Expression and functional properties of TRPM2 channels in dopaminergic neurons of the substantia nigra of the rat.
Topics: Adenosine Diphosphate Ribose; Adenosine Triphosphate; Animals; Biophysics; Calcium; Clusterin; Dopaminergic Neurons; Dose-Response Relationship, Drug; Electric Stimulation; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Glyburide; Hydrogen Peroxide; In Vitro Techniques; Isoquinolines; Membrane Potentials; Oxidants; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Rats; Reactive Oxygen Species; RNA, Messenger; Substantia Nigra; Tetraethylammonium; Tolbutamide; Tyrosine 3-Monooxygenase | 2011 |
Structural nucleotide analogs are potent activators/inhibitors of pancreatic β cell KATP channels: an emerging mechanism supporting their use as antidiabetic drugs.
Topics: Animals; Area Under Curve; Benzoxazines; Blood Glucose; Dose-Response Relationship, Drug; Electrophysiological Phenomena; Fasting; Glucose; Glucose Tolerance Test; Glyburide; HEK293 Cells; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; KATP Channels; Membrane Potentials; Mice; Mice, Inbred Strains; Patch-Clamp Techniques; Potassium Channels, Inwardly Rectifying; Sodium Azide; Tolbutamide | 2012 |
Protein phosphorylation involved in the gene expression of the hydrogen sulphide producing enzyme cystathionine γ-lyase in the pancreatic β-cell.
Topics: Animals; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; ets-Domain Protein Elk-1; Gene Expression; Gene Expression Regulation; Glucose; Glyburide; Hydrogen Sulfide; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Sp1 Transcription Factor; Thapsigargin; Tolbutamide | 2012 |
Differential contribution of TM6 and TM12 to the pore of CFTR identified by three sulfonylurea-based blockers.
Topics: Alanine; Amino Acid Sequence; Animals; Benzamides; Cystic Fibrosis Transmembrane Conductance Regulator; Glipizide; Glyburide; Ion Channel Gating; Kinetics; Mutagenesis; Oocytes; Patch-Clamp Techniques; Sulfonylurea Compounds; Tolbutamide; Xenopus | 2012 |
Pharmacogenomic analysis of ATP-sensitive potassium channels coexpressing the common type 2 diabetes risk variants E23K and S1369A.
Topics: ATP-Binding Cassette Transporters; Chlorpropamide; Cyclohexanes; Diabetes Mellitus, Type 2; Gene Expression Regulation; Gliclazide; Glyburide; Haplotypes; Homozygote; Humans; Isoindoles; Nateglinide; Patch-Clamp Techniques; Phenylalanine; Polymorphism, Single Nucleotide; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Structure-Activity Relationship; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide | 2012 |
Synthesis, antidiabetic and hypolipidemic activities of new diethylamine and triethoxysilyl derivatives of tolbutamide on rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diethylamines; Glyburide; Hypoglycemic Agents; Lipoproteins, VLDL; Male; Rats; Rats, Wistar; Silanes; Streptozocin; Tolbutamide; Triglycerides | 2012 |
Activation of glibenclamide-sensitive ATP-sensitive K+ channels during β-adrenergically induced metabolic stress produces a substrate for atrial tachyarrhythmia.
Topics: Adrenergic beta-Agonists; Animals; Disease Models, Animal; Electrophysiologic Techniques, Cardiac; Glyburide; Heart Atria; Heart Conduction System; Isoproterenol; KATP Channels; Male; Potassium Channel Blockers; Rats; Stress, Physiological; Tachycardia; Time Factors; Tolbutamide | 2012 |
Mortality outcomes of different sulphonylurea drugs: the results of a 14-year cohort study of type 2 diabetic patients.
Topics: Adult; Aged; Cardiovascular Diseases; Cause of Death; Cohort Studies; Confounding Factors, Epidemiologic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Follow-Up Studies; Gliclazide; Glyburide; Humans; Hypoglycemic Agents; Insulin; Kaplan-Meier Estimate; Male; Metformin; Middle Aged; Neoplasms; Odds Ratio; Proportional Hazards Models; Research Design; Retrospective Studies; Risk Assessment; Risk Factors; Sulfonylurea Compounds; Tolbutamide | 2013 |
Mechanosynthesis of pharmaceutically relevant sulfonyl-(thio)ureas.
Topics: Catalysis; Chlorpropamide; Copper; Glyburide; Hypoglycemic Agents; Isothiocyanates; Molecular Structure; Sulfonamides; Tolbutamide | 2014 |
Effect of tolbutamide, glyburide and glipizide administered supraspinally on CA3 hippocampal neuronal cell death and hyperglycemia induced by kainic acid in mice.
Topics: Animals; Blood Glucose; CA3 Region, Hippocampal; Cell Death; Glipizide; Glyburide; Hyperglycemia; Hypoglycemic Agents; Infusions, Intraventricular; Kainic Acid; Male; Mice; Mice, Inbred ICR; Neurons; Sulfonylurea Compounds; Tolbutamide | 2014 |
Metformin in combination with various insulin secretagogues in type 2 diabetes and associated risk of cardiovascular morbidity and mortality--a retrospective nationwide study.
Topics: Aged; Carbamates; Cardiovascular Diseases; Denmark; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Gliclazide; Glipizide; Glyburide; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Morbidity; Myocardial Infarction; Piperidines; Registries; Retrospective Studies; Risk Factors; Stroke; Sulfonylurea Compounds; Tolbutamide | 2015 |
Evidence for a KATP Channel in Rough Endoplasmic Reticulum (rerKATP Channel) of Rat Hepatocytes.
Topics: Adenosine Triphosphate; Animals; Calcium; Cells, Cultured; Charybdotoxin; Endoplasmic Reticulum, Rough; Glyburide; Hepatocytes; KATP Channels; Male; Membrane Potentials; Peptides; Rats; Tolbutamide | 2015 |
Sulphonylurea receptor-1, sulphonylureas and amplification of insulin secretion by Epac activation in β cells.
Topics: Acetylcysteine; Animals; Bucladesine; Cyclic AMP-Dependent Protein Kinases; Erythromycin; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mice, Inbred C57BL; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide | 2016 |
On-Line two dimensional liquid chromatography based on skeleton type molecularly imprinted column for selective determination of sulfonylurea additive in Chinese patent medicines or functional foods.
Topics: Chromatography, Liquid; Counterfeit Drugs; Dietary Supplements; Drugs, Chinese Herbal; Functional Food; Glyburide; Hypoglycemic Agents; Medicine, Chinese Traditional; Nonprescription Drugs; Online Systems; Sulfonylurea Compounds; Tolbutamide | 2017 |
β-Cell-intrinsic β-arrestin 1 signaling enhances sulfonylurea-induced insulin secretion.
Topics: Animals; beta-Arrestin 1; beta-Arrestin 2; Genotype; Glyburide; Guanine Nucleotide Exchange Factors; Hypoglycemic Agents; Insulin Secretion; Insulin-Secreting Cells; Male; Mice; Mice, Knockout; Mice, Transgenic; Phenotype; Signal Transduction; Sulfonylurea Compounds; Tolbutamide | 2019 |
Analysis of Hypoglycemic Drugs by Liquid Chromatography-Tandem Mass Spectrometry.
Topics: Chlorpropamide; Chromatography, High Pressure Liquid; Chromatography, Liquid; Glipizide; Glyburide; Humans; Hypoglycemic Agents; Nateglinide; Pioglitazone; Rosiglitazone; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tolazamide; Tolbutamide | 2024 |