glyburide has been researched along with nicorandil in 147 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.68) | 18.7374 |
| 1990's | 86 (58.50) | 18.2507 |
| 2000's | 41 (27.89) | 29.6817 |
| 2010's | 19 (12.93) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Auchampach, JA; Cavero, I; Gross, GJ | 1 |
| Kreye, VA; Lenz, T; Pfründer, D; Theiss, U | 1 |
| Lathrop, DA; Refsum, H; Tande, PM; Yang, T | 1 |
| Gross, GJ; Pieper, GM | 1 |
| Braida, C; Holzmann, S; Kukovetz, WR; Pöch, G | 1 |
| Cook, D; Stockbridge, N; Vollrath, B; Weir, B; Zhang, H | 1 |
| Akima, M; Imagawa, J; Nabata, H; Taira, N | 1 |
| Fukata, Y; Fukushima, H; Jinno, Y; Kaneta, S; Nishikori, K; Ogawa, N | 1 |
| Kau, ST; Li, JH; Zografos, P | 1 |
| Kamijo, T; Kido, H; Miwa, A; Nakamura, F; Sugimoto, T; Tomaru, T; Uchida, Y | 1 |
| Hamaguchi, M; Imai, S; Ishibashi, T | 1 |
| Borg, C; Cavero, I; Mestre, M; Mondot, S | 1 |
| Higuera, TR; Kadowitz, PJ; Kvamme, P; Minkes, RK; Nossaman, BD | 1 |
| Kreye, VA; Lenz, T; Theiss, U | 1 |
| Satoh, K; Taira, N; Yamada, H | 1 |
| Ksoll, E; Mackert, JR; Parsons, AA; Schilling, L; Wahl, M | 1 |
| Arakawa, C; Kasuya, Y; Masuda, Y; Miyajima, M; Shigenobu, K; Tanaka, S; Yamashita, T | 1 |
| Fan, Z; Hiraoka, M; Marumo, F; Nakayama, K; Sawanobori, T | 1 |
| Fukamachi, K; Fukumura, F; Kinoshita, K; Kurisu, K; Mitani, A; Nakashima, A; Sakamoto, M; Tokunaga, K; Tsuruhara, Y | 1 |
| Fukushima, H; Harada, K; Jinno, Y; Nishikori, K; Ogawa, N; Ohta, H | 1 |
| Satoh, K; Taira, N; Yamada, H; Yoneyama, F | 1 |
| Taira, N; Teshigawara, T; Yanagisawa, T | 1 |
| Satoh, E; Taira, N; Yanagisawa, T | 1 |
| Satoh, K; Taira, N; Yoneyama, F | 1 |
| Eltze, M | 1 |
| Satoh, H | 2 |
| Kinoshita, M; Nakae, I; Quan, L; Sugimoto, Y; Tsutamoto, T | 1 |
| Fukushima, H; Harada, K; Izawa, T; Kaneta, S; Miwa, A; Ogawa, N | 1 |
| Fukushima, H; Jinno, Y; Kaneta, S; Miwa, A; Ogawa, N | 1 |
| Dawodu, AA; Iwashiro, K; Monti, F; Puddu, PE; Schiariti, M; Sugimoto, S | 1 |
| Masuda, Y; Tanaka, S; Yamashita, T | 1 |
| Bender, AS; White, HS; Woodbury, DM | 1 |
| Orito, K; Satoh, K; Taira, N; Yoneyama, F | 1 |
| Auchampach, JA; Gross, GJ; Pieper, GM; Yao, Z | 1 |
| Akamatsu, S; Dohi, S; Iida, H; Ishiyama, T; Ohta, S; Shimonaka, H | 1 |
| Inukai, H; Murase, K; Park, JB; Ryu, PD; Tanifuji, M; Yamashita, S | 1 |
| Campa, PP; Marino, B; Monti, F; Puddu, PE; Schiariti, M; Sugimoto, S | 1 |
| Hashimoto, K; Kinoshita, M; Nakae, I; Quan, L; Sugimoto, Y; Tsutamoto, T | 1 |
| Fukata, Y; Fukushima, H; Harada, K; Kasai, H; Ogawa, N | 1 |
| Fukata, Y; Fukushima, H; Jinno, Y; Kaneta, S; Ogawa, N; Okada, Y; Yokoyama, T | 1 |
| Abe, S; Kanaide, H; Nakamura, M; Nishimura, J | 1 |
| Jun, JY; Kim, KW; Kim, SJ | 1 |
| Iimura, O; Itoya, M; Iwamoto, T; Miura, T; Shimamoto, K; Urabe, K | 1 |
| Mori, T; Satoh, K; Taira, N; Yamada, H | 1 |
| Fukata, Y; Fukushima, H; Jinno, Y; Kaneta, S; Miwa, A; Ogawa, N | 1 |
| Nakaya, H | 1 |
| Fukushima, H; Jinno, Y; Kaneta, S; Kasai, H; Miwa, A; Motoki, K; Ogawa, N; Okada, Y | 1 |
| Allard, B; Lazdunski, M | 1 |
| Okamoto, K; Sakuta, H; Watanabe, Y | 1 |
| Okamoto, K; Sakuta, H | 1 |
| Auchampach, JA; Gross, GJ; Warltier, DC | 1 |
| Campa, PP; Dawodu, AA; del Monte, F; Marino, B; Monti, F; Puddu, PE; Schiariti, M; Sugimoto, S | 1 |
| Bloch, G; Grousset, C; Kevelaitis, E; Menasché, P; Mouas, C; Piwnica, A | 1 |
| Akai, K; Kanatsuka, H; Komaru, T; Kumagai, T; Sato, K; Sekiguchi, N; Shirato, K; Sugimura, A; Wang, Y | 1 |
| Hara, Y; Kimura, S; Kobayashi, S; Masuda, Y; Nakaya, H; Saito, T; Takizawa, T | 1 |
| O'Rourke, ST | 1 |
| Gross, GJ; Mizumura, T; Nithipatikom, K | 1 |
| Jahangir, A; Jahangir, R; López, JR; Shen, WK; Terzic, A | 1 |
| Asayama, J; Katamura, M; Kawahara, A; Kobara, M; Matoba, S; Nakagawa, C; Nakagawa, M; Ohta, B; Tanaka, T; Tatsumi, T; Tsuruyama, K | 1 |
| Chujo, M; Hori, M; Inoue, M; Kamada, T; Kitakaze, M; Komamura, K; Minamino, T; Mori, H; Node, K; Shinozaki, Y | 1 |
| Angus, JA; Fujiwara, T | 1 |
| Brading, AF; Teramoto, N | 1 |
| Horio, Y; Isomoto, S; Kondo, C; Kurachi, Y; Matsumoto, S; Shindo, T; Yamada, M | 1 |
| Cavero, I; Gross, GJ; Schultz, JE; Yao, Z | 1 |
| Kinoshita, M; Liu, Q; Matsumoto, T; Nakae, I; Omura, T; Takahashi, M; Takaoka, A | 1 |
| Houchi, H; Nakaya, Y; Oka, M; Shono, M | 1 |
| André-Fouät, X; Loufoua, J; Minaire, Y; Ovize, M; Pop, C; Rioufol, G | 1 |
| Arai, M; Fujiwara, H; Fujiwara, T; Kariya, T; Minatoguchi, S; Ohno, Y; Uno, Y; Yamashita, K | 1 |
| Saito, K; Sakai, K | 5 |
| Cogolludo, AL; Pérez-Vizcaíno, F; Tamargo, J; Villamor, E | 1 |
| Asanagi, M; Miyazaki, T; Miyoshi, S; Moritani, K; Ogawa, S | 1 |
| Davie, CS; Standen, NB | 1 |
| Akima, M; Kamachi, S; Kitajima, S; Moriyasu, M; Sakai, K | 1 |
| Guo, ZG; Shi, DH | 1 |
| Davie, CS; Kubo, M; Standen, NB | 1 |
| Geshi, E; Ishioka, H; Katagiri, T; Nakatani, M; Nomizo, A | 2 |
| Hettrick, DA; Kersten, JR; Pagel, PS; Schmeling, T; Tessmer, J; Warltier, DC | 1 |
| Kwan, YW; Lau, WM; To, KW; Tsang, SH | 1 |
| Crozatier, B; Guenoun, T; Laplace, M; Montagne, O; Roser, F | 1 |
| Akima, M; Katsuyama, I; Sakai, K | 1 |
| Cogolludo, AL; Fajardo, S; Ibarra, M; Pérez-Vizcaíno, F; Tamargo, J | 1 |
| Asano, T; Dohi, S; Iida, H | 1 |
| Bayerle-Eder, M; Eichler, HG; Langenberger, H; Pleiner, J; Polak, K; Polska, E; Rainer, G; Schmetterer, L; Teherani, D; Wolzt, M | 1 |
| Obata, T; Yamanaka, Y | 1 |
| Tiritilli, A | 1 |
| Hashimoto, M; Hossain, S; Kubota, Y; Kunitomo, M; Sasaki, T; Shido, O; Shinozuka, K; Tamura, K; Tanaka, N | 1 |
| Deng, HW; Li, YJ; Xiao, J; Ye, F; Zhou, ZH | 1 |
| Hara, K; Hara, S; Higashi, T; Horinaka, S; Kobayashi, N; Matsuoka, H | 1 |
| Brioni, JD; Hsieh, GC; Kolasa, T; Sullivan, JP | 1 |
| Iwamoto, Y; Ohta, M; Wasada, T; Yano, T; Yui, N | 1 |
| Dairaku, Y; Ikeda, Y; Iwamoto, H; Iwatate, M; Kawamura, S; Kimura, M; Maekawa, T; Matsuzaki, M; Mikami, S; Miura, T; Okamura, T; Tatsuno, H | 1 |
| Goswami, SG; Patel, HM; Santani, DD | 1 |
| Ertl, G; Horn, M; Hügel, S; Neubauer, S; Schnackerz, KD; Schroeder, M | 1 |
| Chou, TF; Lee, TM; Lee, YT; Su, SF; Tsai, CH | 1 |
| Koga, Y; Okuda, T; Yamazumi, I | 1 |
| Heywood, GJ; Thomas, PS | 1 |
| Danuser, H; Hauser, DS; Mevissen, M; Portier, CJ; Scholtysik, G; Studer, UE; Walter, B; Weiss, R | 1 |
| Asakura, M; Asanuma, H; Hori, M; Kim, J; Kitakaze, M; Liao, Y; Minamino, T; Node, K; Ogai, A; Ogita, H; Sanada, S; Takashima, S | 1 |
| Genda, S; Ichikawa, Y; Miki, T; Miura, T; Shimamoto, K | 1 |
| Debska, G; Elger, CE; Kicinska, A; Kunz, WS; May, R; Skalska, J; Szewczyk, A | 1 |
| Chou, TF; Lee, TM | 1 |
| Kito, Y; Suzuki, H | 1 |
| Di Girolamo, N; Heywood, GJ; Thomas, PS; Wei, XM | 1 |
| Busija, DW; Horiguchi, T; Kis, B; Nagy, K; Rajapakse, NC; Snipes, JA | 1 |
| Genka, C; Higashijima, N; Hirota, Y; Ishida, H; Nakaya, H; Nakazawa, H; Sato, T | 1 |
| Maddock, HL; Siedlecka, SM; Yellon, DM | 1 |
| Miki, T; Miura, T | 1 |
| Chang, NC; Lee, TM; Lin, MS; Tsai, CH | 2 |
| Fuchigami, T; Kakinohana, M; Murata, K; Nakamura, S; Sugahara, K | 1 |
| Chen, JL; Gao, RL; Kang, LM; Wu, Y; Yang, YJ; Zhao, JL | 1 |
| Deng, CY; Jin, SQ; Niu, LJ; Yao, ZB; Zhou, YJ | 1 |
| Ashour, OM; Hassan, MK; Ismail, HA; Khalifa, MM | 1 |
| Ishii, K; Kametaka, S; Mori, A; Nakahara, T; Ogawa, N; Saito, M; Sakamoto, K | 1 |
| Chang, NC; Lee, TM; Lin, MS | 2 |
| Gao, RL; Pei, WD; Sun, YH; Yang, YJ; Zhai, M; Zhang, YH; Zhao, JL | 1 |
| Ernest, K; Faruqui, AR; George, J; Mathai, J; Neelakantan, N; Peedicayil, J | 1 |
| Faury, G; Raveaud, S; Verdetti, J | 1 |
| Argaud, L; Couture-Lepetit, E; Garrier, O; Gateau-Roesch, O; Gomez, L; Loufouat, J; Ovize, M; Robert, D | 1 |
| Chang, NC; Chen, CC; Kang, CS; Lee, TM; Lin, CC | 1 |
| Hirai, K; Kobayashi, K; Matsumoto, K; Odawara, H; Oshima, K; Sato, H; Suto, Y; Takeyoshi, I; Yamazaki, H | 1 |
| Dimitriadis, F; Kinoshita, Y; Ohmasa, F; Saito, M; Satoh, I; Satoh, K; Shimizu, S; Taniguchi, S | 1 |
| Daida, H; Matsumoto, A; Miyata, Y; Nakaya, H; Nakazato, Y; Nishimura, N; Ogura, T; Reien, Y; Suzuki, K | 1 |
| Eguchi, S; Kawano, H; Kawano, T; Nakaya, Y; Oshita, S; Takahashi, A; Tanaka, K | 1 |
| Arakawa, K; Matsumoto, K; Oshima, K; Sato, H; Suto, Y; Takeyoshi, I; Yamazaki, H | 1 |
| Babelova, A; Brandes, RP; Buerkl, J; Hofstetter, C; Kirschning, T; Mieth, A; Neofitidou, S; Revermann, M; Schermuly, RT; Schloss, M; Schröder, K | 1 |
| Bahler, CK; Chang, M; Chowdhury, UR; Fautsch, MP; Hann, CR; Resch, ZT; Romero, MF | 1 |
| Dimitriadis, F; Kinoshita, Y; Kitatani, K; Ohmasa, F; Oiwa, H; Saito, M; Satoh, K; Shomori, K; Tsounapi, P | 1 |
| Hirata, Y; Morita, T; Nagai, R; Sahara, M; Sata, M | 1 |
| Ishii, K; Moriuchi, H; Nakahara, T; Sakamoto, K; Yunoki, M | 1 |
| Araújo, DP; Bastos, LF; César, IC; Coelho, MM; de Fátima, Â; Dutra, MM; Ferreira, WC; Godin, AM; Machado, RR; Menezes, RR; Nascimento, EB; Pianetti, GA; Seniuk, JG; Soares, DG | 1 |
| Abdel-Raheem, IT; Abouzied, MM; Taye, A | 1 |
| Fukuoka, N; Iida, H; Iida, M; Iwata, K; Takenaka, M; Tanabe, K; Uchida, M | 1 |
| Aizawa, K; Ishizuka, N; Serizawa, K; Tashiro, Y; Yogo, K | 1 |
| Ahmed, LA; El-Maraghy, SA; Rizk, SM | 1 |
| Nakashima, M; Obata, T | 1 |
| Adachi, T; Fujisawa, S; Hongoh, M; Ohba, T; Ono, K; Shimbo, T | 1 |
2 review(s) available for glyburide and nicorandil
| Article | Year |
|---|---|
[Potential role of ATP-sensitive K+ channels in ischemia- and reperfusion-induced arrhythmias].
Topics: Action Potentials; Adenosine Triphosphate; Animals; Arrhythmias, Cardiac; Benzopyrans; Cromakalim; Glyburide; Guanidines; Humans; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Niacinamide; Nicorandil; Pinacidil; Potassium; Potassium Channels; Pyrroles; Tolbutamide | 1993 |
ATP-sensitive K+ channel openers: old drugs with new clinical benefits for the heart.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Coronary Disease; Diazoxide; Glyburide; Humans; Ion Channel Gating; Myocardial Reperfusion Injury; Nicorandil; Pinacidil; Potassium Channel Blockers; Potassium Channels; Randomized Controlled Trials as Topic; Vasodilator Agents | 2003 |
4 trial(s) available for glyburide and nicorandil
| Article | Year |
|---|---|
Hypercapnia-induced cerebral and ocular vasodilation is not altered by glibenclamide in humans.
Topics: Adenosine Triphosphate; Administration, Inhalation; Adult; Blood Glucose; Blood Pressure; Brain; Brain Chemistry; Carbon Dioxide; Cerebrovascular Circulation; Eye; Forearm; Glyburide; Heart Rate; Humans; Hypercapnia; Hypoglycemic Agents; Insulin; Male; Nicorandil; Potassium Channels; Regional Blood Flow; Vasodilation; Vasodilator Agents | 2000 |
Loss of preconditioning by attenuated activation of myocardial ATP-sensitive potassium channels in elderly patients undergoing coronary angioplasty.
Topics: Adult; Aged; Aging; Angioplasty, Balloon, Coronary; ATP-Binding Cassette Transporters; Chest Pain; Coronary Disease; Electrocardiography; Female; Glyburide; Hemodynamics; Humans; Ischemic Preconditioning, Myocardial; KATP Channels; Lactic Acid; Male; Middle Aged; Myocardium; Nicorandil; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying | 2002 |
Effect of ischaemic preconditioning on regional release of inflammatory markers.
Topics: Adult; Angioplasty, Balloon, Coronary; Biomarkers; Blood Glucose; CD40 Ligand; Electrocardiography; Female; Glyburide; Hemodynamics; Humans; Inflammation Mediators; Insulin; Ischemic Preconditioning, Myocardial; Lactic Acid; Male; Middle Aged; Myocardial Ischemia; Nicorandil; P-Selectin; Peroxidase; Potassium Channel Blockers; Potassium Channels; Prospective Studies | 2005 |
Levosimendan attenuates pulmonary vascular remodeling.
Topics: Airway Remodeling; Animals; Cardiotonic Agents; Disease Models, Animal; Germany; Glyburide; Hydrazones; Hypertension, Pulmonary; Hypoglycemic Agents; Myocardial Contraction; Nicorandil; Potassium Channels; Pulmonary Circulation; Pyridazines; Rats; Rats, Sprague-Dawley; Simendan; Vasodilator Agents | 2011 |
141 other study(ies) available for glyburide and nicorandil
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Nicorandil attenuates myocardial dysfunction associated with transient ischemia by opening ATP-dependent potassium channels.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Blood Pressure; Coronary Circulation; Dogs; Female; Glyburide; Heart; Heart Rate; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Potassium Channels; Ventricular Function, Left | 1992 |
Pharmacological characterization of nicorandil by 86Rb efflux and isometric vasorelaxation studies in vascular smooth muscle.
Topics: Animals; Aorta; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Niacinamide; Nicorandil; Nitroprusside; Potassium Channels; Pyrroles; Rabbits; Rubidium Radioisotopes; Vasodilation; Vasodilator Agents | 1992 |
Class III antiarrhythmic action by potassium channel blockade: dofetilide attenuates hypoxia induced electromechanical changes.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Glyburide; Guinea Pigs; Muscles; Niacinamide; Nicorandil; Oxygen; Papillary Muscles; Phenethylamines; Potassium Channels; Sulfonamides; Vasodilator Agents | 1992 |
Anti-free-radical and neutrophil-modulating properties of the nitrovasodilator, nicorandil.
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Free Radical Scavengers; Free Radicals; Glyburide; Hydroxides; Hydroxyl Radical; In Vitro Techniques; Neutrophils; Niacinamide; Nicorandil; Nitroglycerin; Opsonin Proteins; Superoxides; Tetradecanoylphorbol Acetate; Vasodilator Agents | 1992 |
Pharmacological interaction experiments differentiate between glibenclamide-sensitive K+ channels and cyclic GMP as components of vasodilation by nicorandil.
Topics: Animals; Benzopyrans; Cattle; Coronary Vessels; Cromakalim; Cyclic GMP; Drug Interactions; Glyburide; Guanidines; In Vitro Techniques; Methylene Blue; Molsidomine; Muscle Relaxation; Niacinamide; Nicorandil; Nitroprusside; Pinacidil; Potassium Channels; Pyrroles; Sensitivity and Specificity; Vasodilator Agents | 1992 |
Vasodilatation of canine cerebral arteries by nicorandil, pinacidil and lemakalim.
Topics: Animals; Basilar Artery; Benzopyrans; Cerebral Arteries; Cromakalim; Dogs; Female; Glyburide; Guanidines; Guanylate Cyclase; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilation; Vasodilator Agents | 1992 |
Spasmolytic action of nicorandil in canine conductive coronary arteries in vivo is not modified by glibenclamide.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angiocardiography; Animals; Benzopyrans; Coronary Circulation; Coronary Vasospasm; Coronary Vessels; Cromakalim; Dogs; Female; Glyburide; Male; Niacinamide; Nicorandil; Nitroglycerin; Parasympatholytics; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Vasodilator Agents | 1992 |
Comparison of KRN2391 with nicorandil and nifedipine on canine coronary blood flow: antagonism by glibenclamide.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Coronary Circulation; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Heart Rate; Male; Niacinamide; Nicorandil; Nifedipine; Potassium Channels; Pyridines; Vascular Resistance | 1992 |
Comparison of the in vitro effects of K+ channel modulators on detrusor and portal vein strips from guinea pigs.
Topics: Animals; Benzopyrans; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Male; Minoxidil; Muscle, Smooth; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Portal Vein; Potassium Channels; Potassium Chloride; Pyrroles; Vasoconstriction; Vasodilator Agents | 1992 |
[The vasospasmolytic effects of nicorandil, cromakalim and pinacidil on 3,4-diaminopyridine-induced phasic contractions in canine coronary arteries as an experimental vasospasm model].
Topics: 4-Aminopyridine; Amifampridine; Animals; Benzopyrans; Coronary Vasospasm; Cromakalim; Disease Models, Animal; Dogs; Female; Glyburide; Guanidines; In Vitro Techniques; Ion Channel Gating; Male; Methylene Blue; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1992 |
2-Nicotinamidoethyl acetate (SG-209) is a potassium channel opener: structure activity relationship among nicorandil derivatives.
Topics: Animals; Cyclic GMP; Glyburide; Male; Methylene Blue; Niacinamide; Nicorandil; Phenylephrine; Potassium Channels; Rabbits; Structure-Activity Relationship; Vasodilation; Vasodilator Agents | 1991 |
Nicorandil: differential contribution of K+ channel opening and guanylate cyclase stimulation to its vasorelaxant effects on various endothelin-1-contracted arterial preparations. Comparison to aprikalim (RP 52891) and nitroglycerin.
Topics: Animals; Coronary Vessels; Endothelins; Endothelium, Vascular; Glyburide; Guanylate Cyclase; Heart; Hemodynamics; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Picolines; Potassium Channels; Purinones; Pyrans; Rats; Rats, Inbred Strains; Stimulation, Chemical; Swine; Swine, Miniature; Vasodilator Agents | 1991 |
Analysis of pulmonary and systemic vascular responses to cromakalim, an activator of K+ATP channels.
Topics: Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Blood Circulation; Cats; Cromakalim; Endothelins; Glyburide; Guanidines; Heart Rate; Hindlimb; Myocardial Contraction; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pulmonary Circulation; Pyrroles; Vascular Resistance; Vasodilator Agents; Ventricular Function, Right | 1991 |
The dualistic mode of action of the vasodilator drug, nicorandil, differentiated by glibenclamide in 86Rb flux studies in rabbit isolated vascular smooth muscle.
Topics: Animals; Aorta; Benzopyrans; Cromakalim; Glyburide; Membranes; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Norepinephrine; Potassium; Potassium Channels; Pyrroles; Rabbits; Rubidium Radioisotopes; Stimulation, Chemical; Vasodilator Agents | 1991 |
Differential antagonism by glibenclamide of the relaxant effects of cromakalim, pinacidil and nicorandil on canine large coronary arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arteries; Benzopyrans; Coronary Vessels; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Guanidines; Male; Methylene Blue; Muscle Contraction; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Pinacidil; Potassium; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Vasodilator Agents | 1991 |
Analysis of cromakalim-, pinacidil-, and nicorandil-induced relaxation of the 5-hydroxytryptamine precontracted rat isolated basilar artery.
Topics: Animals; Basilar Artery; Benzopyrans; Cromakalim; Drug Interactions; Glyburide; Guanidines; Male; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists; Vasoconstriction; Vasodilation; Vasodilator Agents | 1991 |
Potassium channel opening properties of a novel compound, NIP-121, cromakalim and nicorandil in rat aorta and portal vein.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Benzopyrans; Cromakalim; Glyburide; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Oxadiazoles; Phentolamine; Piperidines; Portal Vein; Potassium Channels; Potassium Chloride; Pyrroles; Rats; Rats, Inbred Strains; Rubidium Radioisotopes | 1991 |
Action of nicorandil on ATP-sensitive K+ channel in guinea-pig ventricular myocytes.
Topics: Adenosine Triphosphate; Animals; Glyburide; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Kinetics; Myocardium; Niacinamide; Nicorandil; Potassium Channels; Vasodilator Agents | 1991 |
Effects of glibenclamide and nicorandil on cardiac function during ischemia and reperfusion in isolated perfused rat hearts.
Topics: Adenosine Triphosphate; Animals; Coronary Disease; Glyburide; Heart; Kinetics; Male; Myocardial Contraction; Myocardial Reperfusion; Niacinamide; Nicorandil; Potassium; Potassium Channels; Rats; Rats, Inbred Strains; Ventricular Function, Left | 1991 |
Cardioprotective effects of KRN2391 and nicorandil on ischemic dysfunction in perfused rat heart.
Topics: Animals; Coronary Disease; Cytosol; Glyburide; Heart Rate; In Vitro Techniques; Male; Myocardium; Niacinamide; Nicorandil; Perfusion; Pyridines; Rats; Rats, Inbred Strains; Vasodilator Agents | 1991 |
Specific but differential antagonism by glibenclamide of the vasodepressor effects of cromakalim and nicorandil in spinally-anaesthetized dogs.
Topics: Anesthesia, Spinal; Animals; Benzopyrans; Blood Pressure; Calcium Channel Blockers; Cromakalim; Diltiazem; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Heart Rate; Hemodynamics; Male; Myocardial Contraction; Niacinamide; Nicorandil; Nitroglycerin; Norepinephrine; Potassium Channels; Pyrroles | 1990 |
Cytoplasmic calcium and the relaxation of canine coronary arterial smooth muscle produced by cromakalim, pinacidil and nicorandil.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Coronary Vessels; Cromakalim; Cytoplasm; Dogs; Female; Fluorescence; Glyburide; Guanidines; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pinacidil; Potassium Chloride; Pyrroles; Quaternary Ammonium Compounds | 1990 |
Specific antagonism by glibenclamide of negative inotropic effects of potassium channel openers in canine atrial muscle.
Topics: Animals; Benzopyrans; Carbachol; Cromakalim; Dogs; Female; Glyburide; Guanidines; Heart Atria; Male; Myocardial Contraction; Niacinamide; Nicorandil; Nifedipine; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1990 |
Nicorandil increases coronary blood flow predominantly by K-channel opening mechanism.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Coronary Circulation; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; In Vitro Techniques; Male; Myocardial Contraction; Niacinamide; Nicorandil; Nitroglycerin; Potassium Channels; Pyrroles; Vasodilator Agents | 1990 |
Glibenclamide is a competitive antagonist of cromakalim, pinacidil and RP 49356 in guinea-pig pulmonary artery.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Male; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Picolines; Pinacidil; Potassium Channels; Potassium Chloride; Pulmonary Artery; Purinones; Pyrans; Pyrroles; Tetraethylammonium Compounds | 1989 |
Effects of ATP-sensitive K+ channel openers on pacemaker activity in isolated single rabbit sino-atrial node cells.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; Guanidines; Heart Rate; In Vitro Techniques; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Pyrroles; Rabbits; Sinoatrial Node; Vasodilator Agents | 1993 |
Glibenclamide-induced oscillation of canine coronary artery is independent of myocardial ischemia.
Topics: Adenosine Triphosphate; Animals; Arginine; Benzopyrans; Coronary Circulation; Coronary Vessels; Cromakalim; Diltiazem; Dogs; Female; Glyburide; In Vitro Techniques; Male; Muscle Tonus; Muscle, Smooth, Vascular; Myocardial Ischemia; Niacinamide; Nicorandil; Nitroarginine; Nitroglycerin; Potassium Channels; Pyrroles; Vasodilator Agents | 1994 |
Effects of KRN2391, nicorandil and diltiazem on the changes in the electrocardiogram caused by endothelin-1 in anaesthetized rats.
Topics: Action Potentials; Anesthesia; Animals; Blood Pressure; Cardiac Complexes, Premature; Diltiazem; Electrocardiography; Electrophysiology; Endothelins; Glyburide; Guinea Pigs; Heart Rate; In Vitro Techniques; Male; Methacholine Compounds; Niacinamide; Nicorandil; Pyridines; Rats; Rats, Wistar; Vasodilator Agents; Ventricular Fibrillation | 1993 |
Effect of KRN2391 on venous return: comparison with other vasodilators.
Topics: Animals; Benzopyrans; Cromakalim; Dogs; Female; Glyburide; Hemodynamics; Male; Niacinamide; Nicorandil; Nifedipine; Nitroglycerin; Potassium Channels; Pyridines; Pyrroles; Vasodilator Agents; Veins | 1993 |
The risk of myocardial stunning is decreased concentration-dependently by KATP channel activation with nicorandil before high K+ cardioplegia.
Topics: Adenosine Triphosphate; Animals; Cardioplegic Solutions; Cardiotonic Agents; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Glyburide; Guinea Pigs; Heart Arrest, Induced; Hypothermia, Induced; Isotonic Solutions; Models, Cardiovascular; Multivariate Analysis; Myocardial Contraction; Myocardial Stunning; Niacinamide; Nicorandil; Potassium Channels; Pressure; Risk Factors; Time Factors; Vasodilator Agents | 1995 |
The effects of potassium channel openers and blockers on the specific binding sites for [3H]glibenclamide in rat tissues.
Topics: Animals; Binding Sites; Brain; Cell Membrane; Dose-Response Relationship, Drug; Glyburide; Heart Ventricles; Male; Muscle Contraction; Niacinamide; Nicorandil; Oxadiazoles; Piperidines; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Rubidium; Vasodilator Agents | 1995 |
Ionic dependence of adenosine uptake into cultured astrocytes.
Topics: Adenosine; Animals; Animals, Newborn; Astrocytes; Benzopyrans; Biological Transport; Calcimycin; Calcium; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cells, Cultured; Cerebral Cortex; Cromakalim; Furosemide; Glyburide; Ionophores; Kinetics; Mice; Niacinamide; Nicorandil; Nigericin; Omeprazole; Potassium; Pyrroles; Sodium; Valinomycin; Vasodilator Agents | 1994 |
A further study of the vasodilator and negative inotropic mechanisms of action of nicorandil and its congeners in the canine heart.
Topics: Animals; Coronary Circulation; Depression, Chemical; Dogs; Drug Interactions; Female; Glyburide; Heart; In Vitro Techniques; Male; Myocardial Contraction; Niacinamide; Nicorandil; Papillary Muscles; Potassium Channels; Vasodilator Agents | 1994 |
The ATP-regulated potassium channel in ischemia-reperfusion injury.
Topics: Adenosine Triphosphate; Animals; Dogs; Glyburide; Ion Channel Gating; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Picolines; Potassium Channels; Pyrans; Tolbutamide | 1994 |
Mechanisms of vasodilation of cerebral vessels induced by the potassium channel opener nicorandil in canine in vivo experiments.
Topics: Administration, Topical; Animals; Arterioles; Benzopyrans; Cromakalim; Dimethyl Sulfoxide; Dogs; Glyburide; Methylene Blue; Microcirculation; Niacinamide; Nicorandil; Nitroglycerin; Pia Mater; Pyrroles; Vasodilation; Vasodilator Agents; Venules | 1994 |
Possible presence of the ATP-sensitive K+ channel in isolated spinal dorsal horn neurons of the rat.
Topics: Adenosine Triphosphate; Animals; Cell Separation; Electric Stimulation; Electrophysiology; Glyburide; Minoxidil; Neurons; Niacinamide; Nicorandil; Potassium Channels; Rats; Rats, Sprague-Dawley; Spinal Cord | 1994 |
Pretreatment with the adenosine triphosphate-sensitive potassium channel opener nicorandil and improved myocardial protection during high-potassium cardioplegic hypoxia.
Topics: Action Potentials; Animals; Cardioplegic Solutions; Female; Glyburide; Guinea Pigs; Heart Arrest, Induced; Hypothermia, Induced; In Vitro Techniques; Myocardial Contraction; Niacinamide; Nicorandil; Papillary Muscles; Potassium; Potassium Channels; Time Factors; Vasodilator Agents | 1994 |
Mechanism of the vasodilatory action of nicorandil on coronary circulation in dogs.
Topics: Animals; Benzopyrans; Coronary Circulation; Coronary Vessels; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Hemodynamics; Injections, Intravenous; Male; Niacinamide; Nicorandil; Nitroglycerin; Potassium Channels; Pyrroles; Vasodilator Agents | 1994 |
Dissimilarity in the mechanisms of action of KRN2391, nicorandil and cromakalim in canine renal artery.
Topics: Animals; Benzopyrans; Cromakalim; Dogs; Female; Glyburide; In Vitro Techniques; Male; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitrates; Potassium Channels; Potassium Chloride; Pyridines; Pyrroles; Renal Artery; Vasodilator Agents | 1993 |
Mechanism of action of KRN2391 in canine coronary vascular bed.
Topics: Animals; Antihypertensive Agents; Arteries; Benzopyrans; Coronary Circulation; Coronary Vessels; Cromakalim; Dogs; Drug Interactions; Female; Glyburide; In Vitro Techniques; Male; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pyridines; Pyrroles; Vasodilator Agents | 1993 |
Effects of nicorandil on cytosolic calcium concentrations and on tension development in the rabbit femoral artery.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Cyclic GMP; Femoral Artery; Glyburide; In Vitro Techniques; Male; Niacinamide; Nicorandil; Nitroglycerin; Norepinephrine; Potassium; Potassium Channels; Pyrroles; Rabbits; Vasodilation; Vasodilator Agents | 1994 |
Effects of K-channel openers on the contractility and electrical activity of antral circular muscle in guinea-pig stomach.
Topics: Action Potentials; Animals; Benzopyrans; Cromakalim; Glyburide; Guinea Pigs; In Vitro Techniques; Ion Channel Gating; Muscle Contraction; Muscle, Smooth; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Stomach | 1993 |
Effect of nicorandil on post-ischaemic contractile dysfunction in the heart: roles of its ATP-sensitive K+ channel opening property and nitrate property.
Topics: Adenosine Triphosphate; Animals; Glyburide; Hemodynamics; Infusions, Intravenous; Ion Channel Gating; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardial Stunning; Niacinamide; Nicorandil; Nitrates; Nitroglycerin; Potassium Channels; Premedication; Rabbits; Vasodilator Agents | 1993 |
Nicorandil as a nitrate, and cromakalim as a potassium channel opener, dilate isolated porcine large coronary arteries in an agonist-nonselective manner.
Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Glyburide; In Vitro Techniques; Niacinamide; Nicorandil; Nitrates; Potassium Channels; Pyrroles; Swine; Vasodilator Agents | 1993 |
Mechanism of action of KRN2391, a novel vasodilator, in canine mesenteric artery.
Topics: Animals; Arterioles; Benzopyrans; Cromakalim; Dogs; Female; Glyburide; In Vitro Techniques; Male; Mesenteric Arteries; Methylene Blue; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Pyridines; Pyrroles; Splanchnic Circulation; Vascular Resistance; Vasodilator Agents | 1993 |
Vasorelaxant mechanism of KRN2391 and nicorandil in porcine coronary arteries of different sizes.
Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Glyburide; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Oxyhemoglobins; Potassium Channels; Pyridines; Pyrroles; Swine; Vasodilator Agents | 1993 |
Pharmacological properties of ATP-sensitive K+ channels in mammalian skeletal muscle cells.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Electrophysiology; Glyburide; Guanidines; In Vitro Techniques; Mice; Muscles; Niacinamide; Nicorandil; Organic Chemicals; Pinacidil; Potassium Channels; Pyrroles; Vasodilator Agents | 1993 |
Comparative electrophysiological and mechanical actions of ATP-sensitive potassium channel openers in canine Purkinje fibers.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dogs; Electrophysiology; Glyburide; Guanidines; In Vitro Techniques; Myocardial Contraction; Niacinamide; Nicorandil; Pinacidil; Potassium Channels; Purkinje Fibers; Pyrroles; Tetraethylammonium Compounds; Vasodilator Agents | 1993 |
Modification by cGMP of glibenclamide-sensitive K+ currents in Xenopus oocytes.
Topics: Animals; Benzopyrans; Cromakalim; Cyclic GMP; Female; Glyburide; In Vitro Techniques; Membrane Potentials; Methylene Blue; Niacinamide; Nicorandil; Nitroprusside; Oocytes; Potassium Channels; Pyridines; Pyrroles; Xenopus laevis | 1993 |
Activation by KRN2391 and nicorandil of glibenclamide-sensitive K+ channels in Xenopus oocytes.
Topics: Animals; Benzopyrans; Cromakalim; Electrophysiology; Epinephrine; Female; Glyburide; Niacinamide; Nicorandil; Oocytes; Phentolamine; Potassium Channels; Pyridines; Pyrroles; Trifluoperazine; Vasodilator Agents; Xenopus laevis | 1993 |
Relationship of severity of myocardial stunning to ATP dependent potassium channel modulation.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Dogs; Glyburide; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Potassium Channels; Vasodilator Agents | 1993 |
Activation of ATP-dependent K+ channels enhances myocardial protection due to cold high potassium cardioplegia: a force-frequency relationship study.
Topics: Animals; Cold Temperature; Glyburide; Guinea Pigs; Heart; Heart Arrest, Induced; Ion Channel Gating; Muscle Contraction; Myocardium; Niacinamide; Nicorandil; Nitroglycerin; Potassium; Potassium Channels; Vasodilator Agents | 1995 |
Preconditioning with potassium channel openers. A new concept for enhancing cardioplegic protection?
Topics: Animals; Coronary Circulation; Glyburide; Heart Arrest, Induced; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Potassium Channels; Rats; Rats, Wistar; Ventricular Function, Left | 1995 |
Vasodilatory effect of nicorandil on coronary arterial microvessels: its dependency on vessel size and the involvement of the ATP-sensitive potassium channels.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Blood Glucose; Coronary Circulation; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Female; Glyburide; Hemodynamics; Hydrogen-Ion Concentration; Hypoglycemic Agents; Infusions, Intra-Arterial; Male; Niacinamide; Nicorandil; Potassium Channels; Vasodilator Agents | 1995 |
Endothelin-1 partially inhibits ATP-sensitive K+ current in guinea pig ventricular cells.
Topics: Action Potentials; Adenosine Triphosphate; Alkaloids; Animals; Azepines; Benzopyrans; Cromakalim; Endothelin Receptor Antagonists; Endothelins; Female; Glyburide; Guinea Pigs; Heart; Heart Ventricles; Hypoglycemic Agents; Male; Niacinamide; Nicorandil; Oligopeptides; Papillary Muscles; Potassium Channels; Protein Kinase C; Pyrroles; Staurosporine; Sulfonamides; Vasodilator Agents | 1996 |
KATP channel activation mediates nicorandil-induced relaxation of nitrate-tolerant coronary arteries.
Topics: Animals; Coronary Vessels; Dose-Response Relationship, Drug; Drug Tolerance; Glyburide; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitroglycerin; Potassium Channels; Swine; Vasodilator Agents | 1996 |
Infarct size-reducing effect of nicorandil is mediated by the KATP channel but not by its nitrate-like properties in dogs.
Topics: Adenosine; Animals; Dogs; Female; Glyburide; Ion Channel Gating; Male; Methylene Blue; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Niacinamide; Nicorandil; Nitric Oxide; Nitroglycerin; Potassium Channels; Vasodilator Agents | 1996 |
Potassium channel openers prevent potassium-induced calcium loading of cardiac cells: possible implications in cardioplegia.
Topics: Adenosine Triphosphate; Aniline Compounds; Animals; Calcium; Calcium Channel Blockers; Cardioplegic Solutions; Cells, Cultured; Fluorescent Dyes; Glyburide; Guinea Pigs; Heart Arrest, Induced; Heart Ventricles; Hypertonic Solutions; Image Processing, Computer-Assisted; Ion Channel Gating; Microscopy, Confocal; Myocardium; Niacinamide; Nicorandil; Picolines; Potassium; Potassium Channel Blockers; Potassium Channels; Pyrans; Ventricular Dysfunction; Xanthenes | 1996 |
Effects of glibenclamide and nicorandil in post-ischaemic contractile dysfunction of perfused hearts in normotensive and spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Cardiac Volume; Creatine Kinase; Glyburide; Heart Rate; Hemodynamics; Hypertension; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Niacinamide; Nicorandil; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors | 1996 |
Role of activation of ectosolic 5'-nucleotidase in the cardioprotection mediated by opening of K+c channels.
Topics: 5'-Nucleotidase; Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Dogs; Enzyme Activation; Glyburide; Heart; Hemodynamics; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Recurrence | 1996 |
Analysis of relaxation and repolarization mechanisms of nicorandil in rat mesenteric artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzopyrans; Calcium Channel Blockers; Cromakalim; Electrophysiology; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Male; Membrane Potentials; Mesenteric Arteries; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nifedipine; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Rats; Rats, Sprague-Dawley; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents | 1996 |
Nicorandil activates glibenclamide-sensitive K+ channels in smooth muscle cells of pig proximal urethra.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Cromakalim; Cyclic GMP; Female; Glyburide; Membrane Potentials; Muscle, Smooth; Niacinamide; Nicorandil; Potassium Channels; Pyrroles; Swine; Urethra | 1997 |
Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Cloning, Molecular; Glyburide; Guanidines; Guanosine Diphosphate; Guanosine Triphosphate; Hypoglycemic Agents; KATP Channels; Macromolecular Substances; Magnesium; Mice; Molecular Sequence Data; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Patch-Clamp Techniques; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Compounds; Sulfonylurea Receptors; Uridine Diphosphate; Vasodilator Agents | 1997 |
Glibenclamide-induced blockade of ischemic preconditioning is time dependent in intact rat heart.
Topics: Animals; Antihypertensive Agents; Blood Glucose; Glyburide; Heart; Hemodynamics; Hypotension; Ischemic Preconditioning; Male; Myocardial Infarction; Niacinamide; Nicorandil; Rats; Rats, Wistar; Time Factors | 1997 |
Heterogeneity in the vasorelaxing effect of nicorandil on dog epicardial coronary arteries: comparison with other NO donors.
Topics: Animals; Atrial Natriuretic Factor; Benzopyrans; Coronary Vessels; Cromakalim; Cyclic GMP; Dogs; Female; Glyburide; In Vitro Techniques; Male; Methylene Blue; Molsidomine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Nicorandil; Nitric Oxide; Nitroglycerin; Nitroprusside; Oxyhemoglobins; Pyrroles; Vasodilator Agents | 1997 |
Effects of nitroprusside and nicorandil on catecholamine secretion and calcium mobilization in cultured bovine adrenal chromaffin cells.
Topics: Adrenal Medulla; Animals; Calcium; Catecholamines; Cattle; Cells, Cultured; Chromaffin Cells; Glyburide; Niacinamide; Nicorandil; Nifedipine; Nitroprusside; Vasodilator Agents | 1997 |
Ventricular fibrillation in preconditioned pig hearts: role of K+ATP channels.
Topics: Action Potentials; Animals; Blood Glucose; Blood Pressure; Glyburide; Heart; Heart Rate; Ischemic Preconditioning, Myocardial; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Niacinamide; Nicorandil; Potassium Channel Blockers; Potassium Channels; Swine; Time Factors; Vasodilator Agents; Ventricular Fibrillation | 1997 |
Nicorandil reduces myocardial infarct size by opening the K(ATP) channel in rabbits.
Topics: Analysis of Variance; Animals; Blood Pressure; Dose-Response Relationship, Drug; Glyburide; Heart Rate; Linear Models; Male; Myocardial Infarction; Niacinamide; Nicorandil; Potassium Channel Blockers; Potassium Channels; Rabbits; Time Factors; Vasodilator Agents; Ventricular Fibrillation | 1997 |
Enhancement of the vasodepressor response to adenosine by nicorandil in rats: comparison with cromakalim.
Topics: Adenosine; Adenosine Triphosphate; Animals; Blood Pressure; Cromakalim; Drug Synergism; Glyburide; Heart Rate; Male; Niacinamide; Nicorandil; Potassium Channels; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1998 |
Role of K+ channel opening and stimulation of cyclic GMP in the vasorelaxant effects of nicorandil in isolated piglet pulmonary and mesenteric arteries: relative efficacy and interactions between both pathways.
Topics: Animals; Cromakalim; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; In Vitro Techniques; Male; Mesenteric Arteries; Niacinamide; Nicorandil; Nitroprusside; Potassium Channels; Pulmonary Artery; Swine; Vasodilator Agents; Verapamil | 1998 |
Differential role of epicardial and endocardial K(ATP) channels in potassium accumulation during regional ischemia induced by embolization of a coronary artery with latex.
Topics: Adenosine Triphosphate; Algorithms; Animals; Coronary Vessels; Dogs; Embolization, Therapeutic; Endocardium; Glyburide; Microelectrodes; Microspheres; Myocardial Ischemia; Niacinamide; Nicorandil; Pericardium; Potassium; Potassium Channel Blockers; Potassium Channels; Vasodilator Agents | 1998 |
Potentiating effect of nicorandil on the adenosine A2 receptor-mediated vasodepression in rats: potential role for KATP channels.
Topics: Adenosine; Animals; Antihypertensive Agents; Blood Pressure; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Heart Rate; Injections, Intravenous; Male; Niacinamide; Nicorandil; Potassium Channels; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Theobromine; Vasodilator Agents | 1998 |
Enhancement of the vasorelaxant potency of nicorandil by metabolic inhibition and adenosine in the pig coronary artery.
Topics: 2-Chloroadenosine; Animals; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Coronary Vessels; Glucose; Glyburide; Hydrogen-Ion Concentration; Hypoglycemic Agents; In Vitro Techniques; Ionophores; Niacinamide; Nicorandil; Potassium Channels; Swine; Vasodilator Agents | 1998 |
Interrelationship of cardiovascular effects, plasma levels of nicorandil, and vascular cGMP formation in conscious rats.
Topics: Administration, Oral; Animals; Blood Pressure; Cyclic GMP; Glyburide; Hypoglycemic Agents; Male; Niacinamide; Nicorandil; Rats; Rats, Sprague-Dawley; Time Factors; Vasodilator Agents | 1998 |
Synergism between low-dose nicorandil and neuropeptides on adenosine-induced vasodepression in rats.
Topics: Adenosine; Animals; Dose-Response Relationship, Drug; Drug Synergism; Glyburide; Male; Neuropeptides; Nicorandil; Rats; Rats, Sprague-Dawley; Theobromine; Vasoactive Intestinal Peptide; Vasodilator Agents | 1998 |
Potassium channel openers inhibit ATP-induced cytosolic free calcium increase in cultured rabbit aortic smooth muscle cells.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Calcium; Cells, Cultured; Cromakalim; Glyburide; Muscle, Smooth, Vascular; Nicorandil; Pinacidil; Potassium Channels; Rabbits | 1996 |
Comparison of the potentiating effects of nicorandil and its denitrated metabolite (SG-86) on the adenosine-induced vasodepression in rats.
Topics: Adenosine; Animals; Dose-Response Relationship, Drug; Drug Synergism; Glyburide; Hypoglycemic Agents; Injections, Intravenous; Male; Niacinamide; Nicorandil; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasodilator Agents | 1998 |
Potassium channel activation and relaxation by nicorandil in rat small mesenteric arteries.
Topics: Aminoquinolines; Animals; Calcium Channels; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Electrophysiology; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; In Vitro Techniques; Male; Membrane Potentials; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Nicorandil; Patch-Clamp Techniques; Peptides; Potassium Channels; Rats; Rats, Wistar; Uncoupling Agents; Vasodilator Agents | 1998 |
Biochemical and ultrastructural evaluations of the effect of ischemic preconditioning on ischemic myocardial injury--role of the adenosine triphosphate-sensitive potassium channel.
Topics: Adenosine Triphosphate; Animals; Blood Flow Velocity; Calcium-Transporting ATPases; Coronary Vessels; Dogs; Electrophoresis, Polyacrylamide Gel; Glyburide; Hemodynamics; Ischemic Preconditioning, Myocardial; Mitochondria, Heart; Myocardial Contraction; Myocardial Ischemia; Myocardium; Nicorandil; Potassium Channels; Sarcoplasmic Reticulum | 1998 |
Sevoflurane selectively increases coronary collateral blood flow independent of KATP channels in vivo.
Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Animals; Collateral Circulation; Coronary Circulation; Dogs; Glyburide; In Vitro Techniques; Methyl Ethers; Microspheres; Nicorandil; Potassium Channel Blockers; Potassium Channels; Sevoflurane | 1999 |
Comparison of the vascular relaxant effects of ATP-dependent K+ channel openers on aorta and pulmonary artery isolated from spontaneously hypertensive and Wistar-Kyoto rats.
Topics: Adenosine Triphosphate; Aminoquinolines; Animals; Aorta, Thoracic; Apamin; Benzopyrans; Charybdotoxin; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Hypertension; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nicorandil; Nitroprusside; Norepinephrine; Picolines; Pinacidil; Potassium; Potassium Channels; Pulmonary Artery; Pyrans; Pyrrolidinones; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilator Agents | 1999 |
Nicorandil, its denitrated metabolite, SG-86 and naturally occurring vasodilators synergistically interact on adenosine-induced vasodepression in rats: special reference to adrenomedullin.
Topics: Adenosine; Adrenomedullin; Animals; Blood Pressure; Blood Vessels; Calcitonin Gene-Related Peptide; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Glyburide; Heart Rate; Hypoglycemic Agents; Infusions, Intravenous; Injections, Intravenous; Male; Niacinamide; Nicorandil; Peptides; Rats; Rats, Sprague-Dawley; Vasoactive Intestinal Peptide; Vasodilator Agents | 1999 |
Cytosolic myocardial calcium modulation by ATP-dependent potassium channel openers and NO donors.
Topics: Adenosine Triphosphate; Animals; Calcium; Cardiac Pacing, Artificial; Cytosol; Glyburide; Heart Ventricles; Hypoglycemic Agents; Male; Molsidomine; Myocardium; Nicorandil; Nitric Oxide Donors; Picolines; Potassium Channels; Pyrans; Rats; Rats, Wistar; Vasodilator Agents | 1999 |
Effects of nicorandil on experimentally induced gastric ulcers in rats: a possible role of K(ATP) channels.
Topics: Adenosine Triphosphate; Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Gastric Acid; Gastric Mucosa; Glyburide; Hypoglycemic Agents; Immersion; Male; Nicorandil; Potassium Channels; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Restraint, Physical; Stomach; Stomach Ulcer; Vasodilator Agents; Water | 1999 |
Effects of nicorandil as compared to mixtures of sodium nitroprusside and levcromakalim in isolated rat aorta.
Topics: Animals; Aorta; Cromakalim; Cyclic GMP; Glyburide; In Vitro Techniques; Male; Nicorandil; Nitroprusside; Norepinephrine; Potassium Chloride; Rats; Rats, Wistar; Vasoconstriction; Vasodilator Agents | 1999 |
The role of ATP-sensitive potassium channels in the mechanism of ischemic preconditioning.
Topics: Adenosine Triphosphatases; Animals; Calcium-Transporting ATPases; Coronary Circulation; Dinitrophenols; Dogs; Electrophoresis, Polyacrylamide Gel; Glyburide; Hemodynamics; Hypoglycemic Agents; Ischemic Preconditioning, Myocardial; Membrane Proteins; Mitochondria, Heart; Myocardial Contraction; Nicorandil; Potassium Channels; Regional Blood Flow; Sarcoplasmic Reticulum; Uncoupling Agents; Vasodilator Agents | 1999 |
Antinociceptive action of epidural K+(ATP) channel openers via interaction with morphine and an alpha(2)- adrenergic agonist in rats.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Analgesia; Analgesics, Opioid; Anesthetics, Combined; Animals; Cromakalim; Dexmedetomidine; Drug Interactions; Drug Synergism; Glyburide; Injections, Epidural; Ion Channel Gating; Male; Morphine; Naloxone; Narcotic Antagonists; Nicorandil; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley | 2000 |
Block of cardiac ATP-sensitive K(+) channels reduces hydroxyl radicals in the rat myocardium.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Cromakalim; Decanoic Acids; Dose-Response Relationship, Drug; Ferrous Compounds; Glyburide; Hydroxy Acids; Hydroxybenzoates; Hydroxyl Radical; Hypoglycemic Agents; Inhibitory Concentration 50; Iron Chelating Agents; Male; Microdialysis; Myocardial Ischemia; Myocardium; Nicorandil; Potassium Channel Blockers; Rats; Rats, Wistar; Salicylates; Time Factors | 2000 |
Guanylate cyclase and not ATP-dependent K(+) channels seems temperature-dependent in smooth muscle relaxation of human umbilical arteries.
Topics: Adenosine Triphosphate; Arginine; Cromakalim; Dose-Response Relationship, Drug; Female; Glyburide; Guanylate Cyclase; Humans; In Vitro Techniques; Molsidomine; Muscle, Smooth, Vascular; Nicorandil; Nitroarginine; Oxadiazoles; Potassium Channels; Pregnancy; Quinoxalines; Serotonin; Temperature; Umbilical Arteries; Vasodilation; Vasodilator Agents | 2000 |
Nicorandil--induced ATP release in endothelial cells of rat caudal artery is associated with increase in intracellular Ca(2+).
Topics: Adenosine; Adenosine Triphosphate; Animals; Antineoplastic Agents; Calcium; Chromatography, High Pressure Liquid; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Hypoglycemic Agents; Indoles; Male; Microscopy, Confocal; Nicorandil; Rats; Rats, Wistar; Suramin; Thapsigargin; Vasodilator Agents | 2001 |
On the mechanism of the protective effects of nitroglycerin and nicorandil in cardiac anaphylaxis.
Topics: Anaphylaxis; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Coronary Circulation; Drug Interactions; Female; Glyburide; Guinea Pigs; Heart; Hemodynamics; Male; Nicorandil; Nitroglycerin; Potassium Channels; Vasodilator Agents | 2001 |
Nicorandil enhances cardiac endothelial nitric oxide synthase expression via activation of adenosine triphosphate-sensitive K channel in rat.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Blood Pressure; Glyburide; Heart Rate; Heart Ventricles; Male; Nicorandil; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Receptors, Drug; RNA, Messenger; Sulfonylurea Receptors; Vasodilator Agents | 2001 |
Dual mechanism of action of nicorandil on rabbit corpus cavernosal smooth muscle tone.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Animals; Enzyme Activation; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nicorandil; Nitroprusside; Oxadiazoles; Penis; Phenylephrine; Potassium Channels; Quinoxalines; Rabbits; Vasodilator Agents | 2001 |
ATP-Sensitive potassium channels modulate glucose transport in cultured human skeletal muscle cells.
Topics: 3-O-Methylglucose; Adenosine Triphosphate; Benzopyrans; Biological Transport; Cells, Cultured; Cyclopentanes; Deoxyglucose; Enzyme Activation; Gliclazide; Glucose; Glyburide; Humans; Hypoglycemic Agents; Insulin; Ion Channel Gating; Muscle, Skeletal; Nicorandil; Potassium Channel Blockers; Potassium Channels; Protein Kinase C; Tetradecanoylphorbol Acetate | 2001 |
Ischemic preconditioning attenuates cardiac sympathetic nerve injury via ATP-sensitive potassium channels during myocardial ischemia.
Topics: Adenosine Triphosphate; Animals; Coronary Circulation; Desipramine; Dialysis Solutions; Diltiazem; Dogs; Glyburide; Heart; Hemodynamics; Ischemic Preconditioning; Myocardial Ischemia; Nicorandil; Norepinephrine; Potassium Channels; Sympathetic Nervous System; Time Factors | 2001 |
Evaluation of the effects of nicorandil on experimentally induced gastric ulcers.
Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Female; Gastric Mucosa; Glyburide; Ligation; Male; Nicorandil; Proteins; Pylorus; Rats; Rats, Wistar; Stomach; Stomach Ulcer | 2001 |
Mechanisms of the effects of nicorandil in the isolated rat heart during ischemia and reperfusion: a 31P-nuclear magnetic resonance study.
Topics: Animals; Anti-Arrhythmia Agents; Coronary Circulation; Glyburide; Heart; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Nicorandil; Phosphorus; Potassium Channels; Rats; Rats, Wistar | 2001 |
Involvement of potassium channels in spinal antinociceptions induced by fentanyl, clonidine and bethanechol in rats.
Topics: Adenosine Triphosphatases; Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Bethanechol; Charybdotoxin; Clonidine; Enzyme Inhibitors; Fentanyl; Glyburide; Injections, Spinal; Male; Motor Activity; Muscarinic Antagonists; Nicorandil; Pain Measurement; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Reaction Time; Spinal Cord | 2001 |
Nicorandil inhibits degranulation and TNF-alpha release from RBL-2H3 cells.
Topics: Animals; beta-N-Acetylhexosaminidases; Calcium; Cell Degranulation; Cell Line; Cytoplasmic Granules; Cytosol; Dinitrophenols; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; Hemoglobins; Indicators and Reagents; Mast Cells; Niacinamide; Nicorandil; Nitric Oxide; Nitric Oxide Donors; Pinacidil; Potassium; Potassium Channel Blockers; Potassium Channels; Rats; Tumor Necrosis Factor-alpha | 2002 |
Inhibition of human and pig ureter motility in vitro and in vivo by the K(+) channel openers PKF 217-744b and nicorandil.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Calcium Channels; Dose-Response Relationship, Drug; Female; Glyburide; Humans; In Vitro Techniques; Ion Channel Gating; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Nicorandil; Pyridines; Swine; Ureter | 2002 |
Opening of the adenosine triphosphate-sensitive potassium channel attenuates cardiac remodeling induced by long-term inhibition of nitric oxide synthesis: role of 70-kDa S6 kinase and extracellular signal-regulated kinase.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Body Weight; Cardiomegaly; Glyburide; Hydralazine; Mitogen-Activated Protein Kinases; NG-Nitroarginine Methyl Ester; Nicorandil; Nitric Oxide; Potassium Channels; Rats; Rats, Inbred WKY; Ribosomal Protein S6 Kinases | 2002 |
K(ATP) channel opening is an endogenous mechanism of protection against the no-reflow phenomenon but its function is compromised by hypercholesterolemia.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Chronic Disease; Coronary Circulation; Disease Models, Animal; Glyburide; Hemodynamics; Hypercholesterolemia; Male; Myocardial Infarction; Nicorandil; Nitric Oxide Synthase; omega-N-Methylarginine; Potassium Channel Blockers; Potassium Channels; Rabbits; Vasodilator Agents | 2002 |
Opening of potassium channels modulates mitochondrial function in rat skeletal muscle.
Topics: Animals; Anti-Arrhythmia Agents; Cell Line; Cell Respiration; Diazoxide; Glutamic Acid; Glyburide; Malates; Membrane Potentials; Mitochondria, Muscle; Muscle, Skeletal; Myoblasts; Nicorandil; Oxidation-Reduction; Oxygen; Potassium Channels; Rats | 2002 |
Impairment of myocardial protection in type 2 diabetic patients.
Topics: Aged; Angioplasty, Balloon, Coronary; Blood Pressure; Chest Pain; Diabetes Mellitus, Type 2; Electrocardiography; Female; Glyburide; Heart Rate; Humans; Hypoglycemic Agents; Ischemic Preconditioning; Lactic Acid; Male; Middle Aged; Myocardial Ischemia; Nicorandil; Potassium Channels; Prospective Studies; Sulfonylurea Compounds; Vasodilator Agents | 2003 |
Modulation of slow waves by hyperpolarization with potassium channel openers in antral smooth muscle of the guinea-pig stomach.
Topics: Adrenergic alpha-Agonists; Animals; ATP-Binding Cassette Transporters; Biological Clocks; Decanoic Acids; Electrophysiology; Female; Gastric Mucosa; Glyburide; Guinea Pigs; Hydroxy Acids; In Vitro Techniques; KATP Channels; Male; Membrane Potentials; Microelectrodes; Mitochondria, Muscle; Muscle Contraction; Muscle, Smooth; Nicorandil; Norepinephrine; Pinacidil; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Pyloric Antrum; Stomach | 2003 |
Nicorandil inhibits the release of TNFalpha from a lymphocyte cell line and peripheral blood lymphocytes.
Topics: B-Lymphocytes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Herpesvirus 4, Human; Humans; Immunoglobulin G; Leukocytes, Mononuclear; Niacinamide; Nicorandil; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Oxadiazoles; Pinacidil; Potassium Channels; Quinoxalines; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2003 |
Diazoxide induces delayed pre-conditioning in cultured rat cortical neurons.
Topics: Animals; Cell Death; Cell Hypoxia; Cell Survival; Cells, Cultured; Cerebral Cortex; Cromakalim; Decanoic Acids; Diazoxide; Enzyme Activation; Enzyme Inhibitors; Glucose; Glyburide; Hydroxy Acids; Ischemic Preconditioning; Mitochondria; Neurons; Neuroprotective Agents; Nicorandil; Nitro Compounds; Oxidative Stress; Propionates; Rats; Rats, Wistar; Succinate Dehydrogenase; Superoxides; Time Factors | 2003 |
Nicorandil attenuates the mitochondrial Ca2+ overload with accompanying depolarization of the mitochondrial membrane in the heart.
Topics: Adenosine Triphosphate; Animals; Calcium; Decanoic Acids; Glyburide; Heart Ventricles; Hydroxy Acids; In Vitro Techniques; Membrane Potentials; Mitochondria, Heart; Myocardial Contraction; Myocytes, Cardiac; Nicorandil; Ouabain; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 2004 |
Myocardial protection from either ischaemic preconditioning or nicorandil is not blocked by gliclazide.
Topics: Animals; Anti-Arrhythmia Agents; Gliclazide; Glyburide; Hypoglycemic Agents; Ischemic Preconditioning; Male; Membrane Potentials; Mitochondria, Heart; Myocardial Infarction; Nicorandil; Rats; Rats, Sprague-Dawley | 2004 |
[Neuron-protective effect of ischemic preconditioning in a rabbit reperfusion model following spinal ischemia].
Topics: Animals; Disease Models, Animal; Glyburide; Ischemic Preconditioning; Male; Neurons; Nicorandil; Potassium Channels; Rabbits; Spinal Cord; Vasodilator Agents | 2005 |
Intrathecal nicorandil and small-dose morphine can induce spastic paraparesis after a noninjurious interval of spinal cord ischemia in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Drug Synergism; Glyburide; Injections, Spinal; Male; Morphine; Nicorandil; Paraparesis, Spastic; Rats; Rats, Sprague-Dawley; Spinal Cord Ischemia; Time Factors | 2006 |
Effect of pravastatin on left ventricular mass in the two-kidney, one-clip hypertensive rats.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Natriuretic Factor; Echocardiography; Gene Expression Regulation; Glyburide; Heart Ventricles; Hydralazine; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Renal; Hypertrophy, Left Ventricular; Male; Nicorandil; Potassium Channels; Pravastatin; Rats; Rats, Wistar; Vasodilator Agents | 2006 |
Nicorandil reduces myocardial no-reflow by protection of endothelial function via the activation of KATP channel.
Topics: Animals; Antihypertensive Agents; Coronary Circulation; Endothelial Cells; Endothelium, Vascular; Glyburide; Myocardial Infarction; Nicorandil; Nitric Oxide Synthase; Organ Size; Potassium Channels; Swine; Swine, Miniature; Up-Regulation | 2006 |
Effect of temperature on the activation of myocardial KATP channel in guinea pig ventricular myocytes: a pilot study by whole cell patch clamp recording.
Topics: Adenosine Triphosphate; Animals; Female; Glyburide; Guinea Pigs; Heart Ventricles; Male; Myocytes, Cardiac; Nicorandil; Patch-Clamp Techniques; Potassium Channels; Temperature | 2006 |
Investigation of the mechanisms underlying the gastroprotective effect of nicorandil.
Topics: Animals; Anti-Ulcer Agents; Cimetidine; Drug Therapy, Combination; Gastric Juice; Glyburide; Hydrogen-Ion Concentration; Immersion; Male; Nicorandil; Potassium Channels; Random Allocation; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Stress, Psychological | 2007 |
Vasodilator effect of nicorandil on retinal blood vessels in rats.
Topics: Analysis of Variance; Animals; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Glyburide; Indomethacin; Male; Nicorandil; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Pinacidil; Potassium Channel Blockers; Rats; Rats, Wistar; Retinal Vessels; Vasodilation; Vasodilator Agents | 2007 |
Effect of pravastatin on sympathetic reinnervation in postinfarcted rats.
Topics: Animals; Blotting, Western; Cardiac Pacing, Artificial; Coronary Vessels; Disease Models, Animal; GAP-43 Protein; Glyburide; Heart; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; KATP Channels; Ligation; Male; Myocardial Infarction; Myocardium; Neurofilament Proteins; Nicorandil; Norepinephrine; Pinacidil; Polymerase Chain Reaction; Potassium Channel Blockers; Pravastatin; Rats; Rats, Wistar; RNA, Messenger; Sympathetic Nervous System; Tachycardia, Ventricular; Time Factors; Tyrosine 3-Monooxygenase; Ventricular Fibrillation; Ventricular Remodeling | 2007 |
Intravenous nicorandil preserves endothelial junctions by decreasing endothelin-1 via activation of ATP-sensitive K+ channel.
Topics: Animals; Antigens, CD; Cadherins; Coronary Vessels; Disease Models, Animal; Endothelial Cells; Endothelin-1; Glyburide; Injections, Intravenous; Intercellular Junctions; KATP Channels; Ligation; Myocardial Infarction; Myocardium; Nicorandil; No-Reflow Phenomenon; Potassium Channel Blockers; Research Design; Swine; Swine, Miniature; Vasodilator Agents | 2007 |
Effect of ATP-sensitive potassium channel agonists on ventricular remodeling in healed rat infarcts.
Topics: Animals; Glyburide; Hemodynamics; Hypertrophy, Left Ventricular; Immunohistochemistry; KATP Channels; Male; Muscle Cells; Myocardial Infarction; Nicorandil; Pinacidil; Rats; Rats, Wistar; Risk Factors; Time Factors; Ventricular Remodeling | 2008 |
Inhibitory effect of nicorandil on the contraction of isolated human urinary bladder detrusor muscle.
Topics: Child; Child, Preschool; Electromyography; Female; Glyburide; Humans; Hypoglycemic Agents; In Vitro Techniques; Infant; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nicorandil; Potassium Chloride; Urinary Bladder; Vasodilator Agents | 2008 |
Nicorandil protects ATP-sensitive potassium channels against oxidation-induced dysfunction in cardiomyocytes of aging rats.
Topics: Adenosine Triphosphate; Aging; Animals; Animals, Newborn; Anti-Arrhythmia Agents; Dinitrobenzenes; Female; Glyburide; Heart Ventricles; Humans; Hypoglycemic Agents; KATP Channels; Myocytes, Cardiac; Nicorandil; Oxidation-Reduction; Patch-Clamp Techniques; Rats; Rats, Wistar | 2009 |
Second-generation sulfonylureas preserve inhibition of mitochondrial permeability transition by the mitochondrial K+(ATP) opener nicorandil in experimental myocardial infarction.
Topics: Animals; Calcium; Gliclazide; Glyburide; Hemodynamics; Male; Mitochondria; Myocardial Infarction; Nicorandil; Potassium Channel Blockers; Potassium Channels; Rabbits; Sulfonylurea Compounds | 2009 |
Effect of ATP-sensitive potassium channel agonists on sympathetic hyperinnervation in postinfarcted rat hearts.
Topics: Animals; Arrhythmias, Cardiac; Echocardiography; Endothelin-1; Glyburide; Heart; Hypoglycemic Agents; Male; Myocardial Infarction; Nerve Growth Factor; Nicorandil; Norepinephrine; Pinacidil; Potassium Channels; Rats; Rats, Wistar; RNA, Messenger; Sympathetic Nervous System; Vasodilator Agents | 2009 |
The effect of nicorandil on ischemia-reperfusion injury in a porcine total hepatic vascular exclusion model.
Topics: Animals; Aspartate Aminotransferases; Glyburide; KATP Channels; L-Lactate Dehydrogenase; Liver; Models, Animal; Nicorandil; Regional Blood Flow; Reperfusion Injury; Swine; Vasodilator Agents | 2011 |
The role of ATP-sensitive potassium channel on acute urinary retention and subsequent catheterization in the rat.
Topics: Animals; Blood Circulation; Blood Pressure; Cromakalim; Dose-Response Relationship, Drug; Female; Glyburide; Ion Channel Gating; KATP Channels; Muscle Contraction; Nicorandil; Potassium Channel Blockers; Potassium Chloride; Rats; Rats, Sprague-Dawley; Urinary Bladder; Urinary Catheterization; Urinary Retention | 2010 |
Effects of nicorandil on the cAMP-dependent Cl- current in guinea-pig ventricular cells.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Chloride Channels; Cyclic AMP; Glyburide; Guinea Pigs; Heart Ventricles; Hypoglycemic Agents; Isoproterenol; Nicorandil; Nitric Oxide Donors; Patch-Clamp Techniques; Pinacidil; S-Nitroso-N-Acetylpenicillamine | 2010 |
Effects of ketamine on nicorandil induced ATP-sensitive potassium channel activity in cell line derived from rat aortic smooth muscle.
Topics: Adenosine Diphosphate; Anesthetics, Dissociative; Animals; Cell Line; Dose-Response Relationship, Drug; Electrophysiological Phenomena; Glyburide; KATP Channels; Ketamine; Myocytes, Smooth Muscle; Nicorandil; Patch-Clamp Techniques; Rats; Stereoisomerism | 2010 |
The effect of nicorandil on small intestinal ischemia-reperfusion injury in a canine model.
Topics: Animals; Disease Models, Animal; Dogs; Female; Glyburide; Intestine, Small; KATP Channels; Male; Mesenteric Arteries; Nicorandil; Reperfusion Injury; Vasodilator Agents | 2011 |
ATP-sensitive potassium (KATP) channel activation decreases intraocular pressure in the anterior chamber of the eye.
Topics: Aged; Aged, 80 and over; Animals; Cells, Cultured; Diazoxide; Female; Glyburide; Guanidines; Humans; Immunohistochemistry; Intraocular Pressure; KATP Channels; Male; Middle Aged; Nicorandil; Organ Culture Techniques; Patch-Clamp Techniques; Pyridines; Rats; Rats, Inbred BN; Reverse Transcriptase Polymerase Chain Reaction; Tonometry, Ocular; Trabecular Meshwork; Vasodilator Agents | 2011 |
Pharmacological preconditioning of ATP-sensitive potassium channel openers on acute urinary retention-induced bladder dysfunction in the rat.
Topics: Animals; Cromakalim; Glyburide; KATP Channels; Male; Nicorandil; Rats; Rats, Sprague-Dawley; Urinary Retention | 2012 |
Nicorandil attenuates monocrotaline-induced vascular endothelial damage and pulmonary arterial hypertension.
Topics: Animals; Antihypertensive Agents; Apoptosis; Blotting, Western; Caspase 3; Cells, Cultured; Drug Therapy, Combination; Endothelium, Vascular; Enzyme Inhibitors; Familial Primary Pulmonary Hypertension; Glyburide; Human Umbilical Vein Endothelial Cells; Humans; Hypertension, Pulmonary; Injections, Intraperitoneal; Male; MAP Kinase Signaling System; Monocrotaline; NG-Nitroarginine Methyl Ester; Nicorandil; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Random Allocation; Rats; Rats, Sprague-Dawley; Signal Transduction; Ventricular Pressure | 2012 |
The relaxant action of nicorandil in bovine tracheal smooth muscle.
Topics: Animals; Cattle; Cromakalim; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth; Nicorandil; Nitroprusside; Oxadiazoles; Peptides; Quinoxalines; Trachea; Vasodilator Agents | 2012 |
Activity of nicorandil, a nicotinamide derivative with a nitrate group, in the experimental model of pain induced by formaldehyde in mice.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Glyburide; Male; Mice; Nicorandil; Oxadiazoles; Pain | 2013 |
Cardioprotective effects of nicorandil, a mitochondrial potassium channel opener against doxorubicin-induced cardiotoxicity in rats.
Topics: Animals; Antihypertensive Agents; Antineoplastic Agents; Cardiovascular Diseases; Dose-Response Relationship, Drug; Doxorubicin; Glutathione; Glyburide; Lipid Peroxidation; Male; NF-kappa B; Nicorandil; Rats; Rats, Wistar; Superoxides; Weight Loss | 2013 |
Nicorandil protects pial arterioles from endothelial dysfunction induced by smoking in rats.
Topics: Acetylcholine; Animals; Arterioles; Cerebrovascular Circulation; Data Interpretation, Statistical; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Hypoglycemic Agents; Male; NG-Nitroarginine Methyl Ester; Nicorandil; Nitric Oxide Synthase; Pia Mater; Rats; Rats, Sprague-Dawley; Smoking; Vasodilation; Vasodilator Agents | 2013 |
GATA-4 transcription factor regulates cardiac COX-2 expression induced by nicorandil in left ventricle of rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cyclooxygenase 2; GATA4 Transcription Factor; Gene Expression Regulation; Glyburide; Guanylate Cyclase; Heart Ventricles; KATP Channels; Male; Nicorandil; Rats; Rats, Sprague-Dawley; RNA, Messenger; Vasodilator Agents | 2014 |
Role of the KATP channel in the protective effect of nicorandil on cyclophosphamide-induced lung and testicular toxicity in rats.
Topics: Acetylglucosaminidase; Animals; Biomarkers; Body Weight; Cyclophosphamide; Cytokines; Glyburide; Histamine; Inflammation Mediators; KATP Channels; Leukotriene C4; Lung; Male; Nicorandil; Organ Size; Oxidative Stress; Protective Agents; Rats; Testis; Testosterone | 2015 |
Opening of ATP-sensitive K(+) (KATP) channels enhance hydroxyl radical generation induced by MPP(+) in rat striatum.
Topics: Animals; Corpus Striatum; Cromakalim; Dopamine; Dose-Response Relationship, Drug; Glyburide; Hydroxybenzoates; Hydroxyl Radical; KATP Channels; Male; Membrane Transport Modulators; Microdialysis; MPTP Poisoning; Nicorandil; Rats, Wistar | 2016 |
In vitro effect of nicorandil on the carbachol-induced contraction of the lower esophageal sphincter of the rat.
Topics: Animals; Carbachol; Diazoxide; Dose-Response Relationship, Drug; Esophageal Sphincter, Lower; Glyburide; In Vitro Techniques; KATP Channels; Muscle Contraction; NG-Nitroarginine Methyl Ester; Nicorandil; Oxadiazoles; Peptides; Pinacidil; Potassium; Quinoxalines; Rats | 2016 |