gly-phe-leu-gly and cyclotriphosphazene-ester

gly-phe-leu-gly has been researched along with cyclotriphosphazene-ester* in 1 studies

Other Studies

1 other study(ies) available for gly-phe-leu-gly and cyclotriphosphazene-ester

Article	Year
A macromolecular prodrug of doxorubicin conjugated to a biodegradable cyclotriphosphazene bearing a tetrapeptide. Bioorganic & medicinal chemistry letters, 2005, Aug-01, Volume: 15, Issue:15 A new biodegradable water-soluble phosphazene trimer-doxorubicin conjugate was synthesized, in which equimolar hydrophilic methoxy-poly(ethylene glycol) with a molecular weight of 350 (MPEG350) and a tumor-specific tetrapeptide (Gly-Phe-Leu-Gly) were grafted to cyclotriphosphazene. The present conjugate exhibited cytotoxicity lower than that of free doxorubicin (IC50=0.10 microM) but a reasonably higher in vitro cytotoxicity (IC50=1.1 microM) against the leukemia L1210 cell line probably due to its enzymatically controlled release. Topics: Animals; Antibiotics, Antineoplastic; Biodegradation, Environmental; Cell Line, Tumor; Doxorubicin; Inhibitory Concentration 50; Leukemia L1210; Magnetic Resonance Spectroscopy; Molecular Weight; Nitriles; Oligopeptides; Phosphorus Compounds; Polyethylene Glycols; Prodrugs; Stereoisomerism	2005

Article

Year

A macromolecular prodrug of doxorubicin conjugated to a biodegradable cyclotriphosphazene bearing a tetrapeptide.

Bioorganic & medicinal chemistry letters, 2005, Aug-01, Volume: 15, Issue:15

A new biodegradable water-soluble phosphazene trimer-doxorubicin conjugate was synthesized, in which equimolar hydrophilic methoxy-poly(ethylene glycol) with a molecular weight of 350 (MPEG350) and a tumor-specific tetrapeptide (Gly-Phe-Leu-Gly) were grafted to cyclotriphosphazene. The present conjugate exhibited cytotoxicity lower than that of free doxorubicin (IC50=0.10 microM) but a reasonably higher in vitro cytotoxicity (IC50=1.1 microM) against the leukemia L1210 cell line probably due to its enzymatically controlled release.

Topics: Animals; Antibiotics, Antineoplastic; Biodegradation, Environmental; Cell Line, Tumor; Doxorubicin; Inhibitory Concentration 50; Leukemia L1210; Magnetic Resonance Spectroscopy; Molecular Weight; Nitriles; Oligopeptides; Phosphorus Compounds; Polyethylene Glycols; Prodrugs; Stereoisomerism

2005