Page last updated: 2024-08-25

glutarimide and 2-piperidone

glutarimide has been researched along with 2-piperidone in 112 studies

Research

Studies (112)

TimeframeStudies, this research(%)All Research%
pre-199055 (49.11)18.7374
1990's4 (3.57)18.2507
2000's19 (16.96)29.6817
2010's28 (25.00)24.3611
2020's6 (5.36)2.80

Authors

AuthorsStudies
Jindal, MN; Patel, NB; Patel, VK1
Cook, WL; Gerald, MC; Gupta, TK; Witiak, DT1
Isono, K; Kobayashi, K; Osada, H; Sonoda, T; Ubukata, M1
Blom, W; Hierck, L; Huijmans, JG; Kelholt-Dijkman, HH; Polder-Mol, AC1
Goehring, RR; Greenwood, TD; Nwokogu, GC; Pisipati, JS; Rogers, TG; Wolfe, JF1
Knabe, J1
Lou, ZX; Marunaka, T; Matsumoto, H; Minami, Y; Otani, T; Yu, QW1
Ho, IK; Kamiyama, H; Kimura, T; Tateoka, Y; Watanabe, K; Yamamoto, I1
Jindal, MN; Patel, NB; Patel, VK; Venkatakrishna-Bhatt, H1
Johnston, GA; Nicholson, GM; Spence, I1
Shull, GE1
Cook, PF; Jahnke, K; Kautz, J; Podschun, B; Schnackerz, KD1
Bieńko, DC; Michalska, D; Morzyk, B; Wojciechowski, W1
Aboagye, FA; Lavaud, C; Massiot, G; Sam, GH1
Chang, NC; Lin, CH; Tsai, MR; Wang, YS1
MALLARD, BG; WILSON, CO2
MARSHALL, PG; VALLANCE, DK1
JALLING, O1
CASS, NM1
CASENTINI, S; MARIANI, L2
CURRY, AS1
KIMURA, ET; RICHARDS, RK1
BRAUN, V; KATTNER, W1
FLODMARK, S; PETERSEN, I; STENBERG, K1
ANDERSON, KW1
PEREMANS, J1
GROSS, F; TURRIAN, H1
MERTES, MP; WILSON, CO1
GENTILI, C1
FABISCH, W2
CHUSID, JG; KOPELOFF, LM1
LINDBLAD, CG1
MACFARLANE, AW; MCKENZIE, JS1
SZORADY, I; TAKACS, O; TOTH, G1
TYLER, DB1
CASAGLIA, G1
CASTELLUCCIO, R1
SOMERS, GF1
ANDERMANN, K1
BUESSOW, H1
CICCARELLI, TV; ESPINOSA, EF; SOTTANO, TA1
DERD', B; TIKHAMIR, N1
PARKASH, O1
BERITIC, T; MARKICEVIC, A1
GIETZ, E; STAHLER, O1
FUKUSHIMA, Y; WADA, T1
ALAMEL, P; GEOFFROY, H1
HOFFMANN, K; KEBERLE, H; RIESS, W1
CAVALIERE, R; MANNI, C; MORICCA, G1
FRATTA, I; SIGG, EB; WUEST, HM1
KEMP, RT; KRAUTH, CA; MONTGOMERY, JA; SCHAEFFER, HJ; SHEALY, YF; STRUCK, RF1
ABOU-ZEID, YM; EL-ZANFALLY, S; KHALIFA, M1
DAVIES, D; NICHOLLS, PJ1
GUROWITZ, WD; JOHNSON, F; STARKOVSKY, NA1
MULLER, P; ROHRER, F1
DUS, V; PATAKFALVI, A1
PETERSEN, I; SELLDEN, U; SODERHOLM, B; STEINWALL, O1
BENICA, WS; WILSON, CO2
Arvelo, F; Blanco, Z; Compagnone, RS; Delle Monache, F; Suárez, AI1
Danishefsky, SJ; Dorn, DC; Gaul, C; Huang, XY; Moore, MA; Njardarson, JT; Shan, D; Tong, WP; Wu, KD1
Fox, DJ; Grainger, DJ; Greig, I; Reckless, J; Warren, S; Wilbert, SM1
Jiang, H; Ju, J; Lim, SK; Seo, JW; Shen, B1
Huang, PQ; Liu, G; Liu, LX; Ruan, YP; Wei, BG; Xu, XQ; Yu, DS1
Guo, ZQ; Huang, PQ; Ruan, YP1
Chang, MY; Chang, NC; Chen, HW; Hsu, RT1
Byun, A; Choi, JW; Lee, CG; Moon, KH; Park, MS1
Geng, CY; Huang, XR; Li, JL; Li, Z; Liu, HL; Sun, CC1
Her, Y; Ju, J; Lim, SK; Seo, JW; Shen, B1
Marchant, RE; Zhu, J1
Basavaiah, D; Reddy, RJ1
Hoffmann, FM; Ju, J; Lim, SK; Peters, NR; Rajski, SR; Seo, JW; Shen, B2
Gershenson, ME; Karasik, BS; Olaya, D; Pereverzev, SV; Sergeev, AV; Wei, J1
Guo, HF; Li, YH; Li, ZR; Tao, PZ; Wang, SQ; Yi, H; Zhang, T1
Kubota, T; Watanabe, Y; Yamazaki, T1
Ghosh, SC; Hong, SH; Senthilkumar, M; Zhang, J1
Rajski, SR; Shen, B1
Gao, RM; He, WY; Ji, XY; Li, YH; Li, ZR; Meng, S; Xue, ST; Zhong, ZJ1
Anderson, RF; Davies, MJ; O'Reilly, RJ; Pattison, DI; Radom, L; Skaff, O1
Goto, R; Hirokata, G; Ishikawa, Y; Ito, A; Kaneda, A; Nishiyama, S; Ozaki, M; Shibasaki, S; Tachibana, M; Takeiri, M; Todo, S; Umezawa, K; Yamashita, K1
Ishikawa, Y; Nishiyama, S; Ota, E; Tachibana, M; Takeiri, M; Umezawa, K1
Chen, J; Deng, H; Li, D; Shen, J; Song, D; Wang, Y; Wang, Z; Xu, R; Zhang, J; Zhang, N1
Meng, Y; Tian, C; Wang, Z; Xiu, P; Zhao, W; Zhou, R1
Bisset, AA; Clarkson, GJ; Desmond, JL; Dishington, A; Ikariya, T; Jones, T; Shiibashi, A; Wills, M1
Chen, Q; Huang, H; Ju, J; Luo, M; Ma, J; Song, Y; Wang, B1
Araújo, IS; das Graças B Zoghbi, M; do S B Brasil, D; Guilhon, GM; Peixoto, RN; Santos, LS; Uetanabaro, AP1
Fürstner, A; Lam, MH; Llaveria, J; Loganzo, F; Maderna, A; Micoine, K; Persich, P1
Diring, S; Fischer, RA; Furukawa, S; Isoda, S; Kamei, K; Khaletskaya, K; Kim, F; Kitagawa, S; Meilikhov, M; Nakahama, M; Reboul, J; Tsujimoto, M1
Grzetic, J; Oomens, J1
Kerubo, LO; Langat, MK; Midiwo, JO; Ndunda, B; Wanjohi, JM1
Deng, Z; Li, Z; Lin, S; Sun, D; Sun, W; Yu, Y1
Bretschneider, T; Heine, D; Hertweck, C; Sundaram, S1
Egert, E; Ton, QC1
Drakulić, BJ; Klaus, AS; Matić, IZ; Popović-Djordjević, JB; Žižak, ŽS1
Khomutnyk, Y; Lachacz, E; Larsen, BJ; Nagorny, P; Soellner, MB; Sun, Z1
Baculi, F; Carmel, G; Condroski, K; Correa, M; Crea, T; Hansen, JD; Hickman, M; LeBrun, L; Liu, W; Lu, CC; Lu, G; Mahmoudi, A; Man, HW; Muller, G; Ruchelman, A; Vocanson, F; Zhang, W1
Cho, SY; Go, A; Ha, JD; Hwang, JY; Jeon, YU; Jo, SH; Kim, JE; Kim, JH; Kim, P; Kim, S; Kim, SA; Lee, CO; Lee, HK; Park, BC; Park, CH; Park, SG; Park, SJ1
Li, JS; Qi, H; Wang, H; Wang, JD; Xiang, WS; Xue, ZL; Zhang, H; Zhao, T; Zhao, XL1
Amelina, AN; Ferko, B; Kromova, TA; Nebolsin, VE; Proskurina, OV; Renner, A; Romanova, J; Rydlovskaya, AV; Schmutz, H1
Poulsen, TB; Svenningsen, EB1
Fukuyoshi, S; Kato, K; Kurimoto, E; Nakayoshi, T; Oda, A1
Arczewska, M; Budziak, I; Kamiński, DM1
Ahn, JS; Heo, KT; Hong, YS; Hwang, BY; Jang, JH; Jang, M; Kim, CJ; Ko, SK; Lee, B; Lee, JK; Park, CS; Park, DJ; Son, S1
Challis, GL; Dashti, Y; Jenner, M; Mahenthiralingam, E; Masschelein, J; Nakou, IT; Romero-Canelón, I1
Friedrich, MG; Schey, KL; Truscott, RJW; Wang, Z1
Burch, AY; Chevrette, MG; Helfrich, EJN; Hemmerling, F; Leopold-Messer, S; Lindow, SE; Lu, X; Medema, MH; Minas, HA; Piel, J; Ueoka, R1
Actis, M; Chai, S; Chen, T; Das, S; Fischer, M; Fu, X; Garrett, SH; Jarusiewicz, J; Jonchere, B; Keramatnia, F; Lee, RE; Li, Y; Li, Z; Mayasundari, A; Min, J; Nishiguchi, G; Nithianantham, S; Potts, PR; Rankovic, Z; Roussel, MF; Shelat, A; Slavish, J; White, SW; Yang, L; Yang, SW; Young, B; Yun, MK1
Guo, E; Le, PY; McCulloch, DG; McKenzie, DR; Murdoch, BJ; Partridge, JG; Sylvander, LA; Tran, HN1

Reviews

1 review(s) available for glutarimide and 2-piperidone

ArticleYear
[The enantioselectivity of drugs].
    Arzneimittel-Forschung, 1989, Volume: 39, Issue:11

    Topics: Barbiturates; Humans; Piperidones; Stereoisomerism; Succinimides

1989

Other Studies

111 other study(ies) available for glutarimide and 2-piperidone

ArticleYear
Study of some newly synthesized glutarimide compounds on skeletal muscle.
    The Indian journal of medical research, 1977, Volume: 66, Issue:2

    Topics: Animals; Anura; Cats; In Vitro Techniques; Muscle Contraction; Muscles; Neuromuscular Junction; Piperidines; Piperidones; Rats

1977
Para-substituted N-acetyl-L(S)- and -D(R)-alpha-amino-N-phenylglutarimides. A structure-activity study of substituent effects on steroselective anticonvulsant activity.
    Journal of medicinal chemistry, 1976, Volume: 19, Issue:12

    Topics: Animals; Anticonvulsants; Ethosuximide; Male; Mice; Phenytoin; Piperidines; Piperidones; Seizures; Stereoisomerism; Structure-Activity Relationship; Trimethadione

1976
Absolute configuration of epiderstatin, a new glutarimide antibiotic produced by Streptomyces pulveraceus.
    The Journal of antibiotics, 1992, Volume: 45, Issue:12

    Topics: Antibiotics, Antineoplastic; Circular Dichroism; Epidermal Growth Factor; Piperidones; Pyridones; Spectrophotometry, Ultraviolet; Streptomyces; X-Ray Diffraction

1992
The detection of abnormal metabolites in MCAD deficiency: a new method.
    Journal of inherited metabolic disease, 1990, Volume: 13, Issue:3

    Topics: Acyl-CoA Dehydrogenase; Amino Acids; Chromatography, Gas; Fatty Acid Desaturases; Glutamates; Glutamic Acid; Glutamine; Glycine; Humans; Mass Spectrometry; Piperidones

1990
Synthesis and anticonvulsant activity of 2-benzylglutarimides.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:3

    Topics: Animals; Anticonvulsants; Benzyl Compounds; Mice; Piperidines; Piperidones; Rats; Rats, Inbred Strains; Structure-Activity Relationship

1990
New glutarimide antibiotics, S-632-B1 and B2. II. Isolation, physico-chemical properties and chemical structure.
    The Journal of antibiotics, 1989, Volume: 42, Issue:5

    Topics: Antifungal Agents; Chemical Phenomena; Chemistry, Physical; Chromatography; Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Conformation; Molecular Structure; Piperidones; Spectrophotometry; Stereoisomerism; Streptomyces

1989
Central effects of N-substituted derivatives of 2,6-dioxopiperidine in mice.
    Research communications in chemical pathology and pharmacology, 1988, Volume: 61, Issue:3

    Topics: Animals; Anticonvulsants; Bemegride; Central Nervous System; Convulsants; Hypnotics and Sedatives; Male; Mice; Piperidines; Piperidones; Sleep; Structure-Activity Relationship

1988
Pharmacology of new glutarimide compounds.
    Biomedica biochimica acta, 1985, Volume: 44, Issue:5

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Behavior, Animal; Diethylamines; Drug Evaluation, Preclinical; Female; Male; Mice; Morpholines; Piperidines; Piperidones; Structure-Activity Relationship

1985
Effects of a depressant/convulsant pair of glutarimides on neuronal activity in the isolated spinal cord of the immature rat.
    Neuropharmacology, 1985, Volume: 24, Issue:6

    Topics: Amino Acids; Animals; Bemegride; Central Nervous System Depressants; Convulsants; Female; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Neurons; Piperidines; Piperidones; Rats; Rats, Inbred Strains; Reflex, Monosynaptic; Spinal Cord

1985
Differential inhibition of protein synthesis: a possible biochemical mechanism of thalidomide teratogenesis.
    Journal of theoretical biology, 1984, Oct-05, Volume: 110, Issue:3

    Topics: Abnormalities, Drug-Induced; Acylation; Animals; Chemical Phenomena; Chemistry; Cycloheximide; Embryonic and Fetal Development; Gene Expression Regulation; Humans; Imides; Models, Biological; Piperidones; Polyamines; Protein Biosynthesis; Pyrimidines; Rabbits; RNA, Messenger; Teratogens; Thalidomide

1984
Acid-base catalytic mechanism of dihydropyrimidinase from pH studies.
    Biochemistry, 1993, May-18, Volume: 32, Issue:19

    Topics: Amidohydrolases; Animals; Binding Sites; Binding, Competitive; Catalysis; Cattle; Deuterium; Hydrogen-Ion Concentration; Kinetics; Liver; Piperidones; Swine; Uracil; Zinc

1993
Glutarimide: a carrier transporting drug through cell membranes.
    Medical hypotheses, 2000, Volume: 54, Issue:3

    Topics: Biological Transport; Cell Membrane; Drug Carriers; Piperidones

2000
Julocrotine, a glutarimide alkaloid from Croton membranaceus.
    Fitoterapia, 2000, Volume: 71, Issue:4

    Topics: Alkaloids; Euphorbiaceae; Humans; Piperidones; Plant Extracts; Plant Roots; Plants, Medicinal

2000
An efficient approach to 3,4-disubstituted pyridin-2-ones. Formal synthesis of mappicine ketone.
    The Journal of organic chemistry, 2003, Jul-11, Volume: 68, Issue:14

    Topics: Indolizines; Piperidones; Pyridones; Quinolines; Sulfones

2003
Glutarimides. III. N-Alkyl and N-aryl-3,3-diethylglutarimides.
    Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1954, Volume: 43, Issue:4

    Topics: Piperidines; Piperidones

1954
Anticonvulsant activity; derivatives of succinimide, glutarimide, thiazolidinedione and methanol, and some miscellaneous compounds.
    The Journal of pharmacy and pharmacology, 1954, Volume: 6, Issue:10

    Topics: Anticonvulsants; Methanol; Piperidones; Pyridines; Succinates; Succinimides; Thiazoles; Thiazolidinediones

1954
Effect of betabeta-methylethyl glutarimide and amytal on rat-liver mitochondrial respiration.
    Nature, 1956, Feb-18, Volume: 177, Issue:4503

    Topics: Amobarbital; Animals; Barbiturates; Cell Respiration; Liver; Mitochondria; Piperidines; Piperidones; Rats

1956
An electro-encephalographic study of the analeptic action of beta beta ethyl methyl glutarimide (megimide). I. Against several barbiturates and other hypnotics. II. Compared with other analeptics and convulsants.
    British journal of anaesthesia, 1956, Volume: 28, Issue:7

    Topics: Barbiturates; Bemegride; Central Nervous System Stimulants; Convulsants; Electroencephalography; Hypnotics and Sedatives; Piperidones

1956
[Hypnotic effect of 3-phenyl-3-ethyl-glutarimide. I. Possibility of synergistic action].
    Bollettino della Societa italiana di biologia sperimentale, 1956, Volume: 32, Issue:6

    Topics: Humans; Hypnotics and Sedatives; Piperidones

1956
[Hypnotic effect of 3-phenyl-3-ethyl-glutarimide. II. Possibility of antagonistic action].
    Bollettino della Societa italiana di biologia sperimentale, 1956, Volume: 32, Issue:6

    Topics: Hostility; Humans; Hypnotics and Sedatives; Piperidones

1956
Interference by beta-methyl-beta-ethyl glutarimide in the determination of barbiturates.
    The Journal of pharmacy and pharmacology, 1957, Volume: 9, Issue:2

    Topics: Barbiturates; Central Nervous System Stimulants; Piperidones

1957
A comparative study of bemegride (beta, beta-methylethyl glutarimide; NP-13; Megimide) as an analeptic in mice.
    Archives internationales de pharmacodynamie et de therapie, 1957, Mar-01, Volume: 110, Issue:1

    Topics: Animals; Bemegride; Central Nervous System Stimulants; Mice; Pentylenetetrazole; Picrotoxin; Piperidones

1957
[High-dosed intravenous beta, beta-methylethyl glutarimide in an acute opiate-barbiturate poisoning].
    Munchener medizinische Wochenschrift (1950), 1957, Aug-30, Volume: 99, Issue:35

    Topics: Analgesics, Opioid; Barbiturates; Central Nervous System Stimulants; Piperidones

1957
Glutarimides. IV. N-alkyl and N-aryl derivatives of 3-phenylglutarimide and 3-phenyl-2-methylglutarimide.
    Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1957, Volume: 46, Issue:3

    Topics: Glutethimide; Humans; Imides; Piperidines; Piperidones

1957
Activation with megimide (beta, beta-methylethyl glutarimide) in electroencephalographic investigations of epileptic conditions.
    Acta psychiatrica et neurologica Scandinavica, 1958, Volume: 33, Issue:1

    Topics: Bemegride; Central Nervous System Stimulants; Electroencephalography; Epilepsy; Humans; Piperidones

1958
The determination of beta-substituted glutarimides in blood: time-concentration curves after intravenous administration of two barbiturate antagonists.
    The Journal of pharmacy and pharmacology, 1958, Volume: 10, Issue:4

    Topics: Barbiturates; Central Nervous System Stimulants; Humans; Infusions, Intravenous; Piperidones

1958
[Effect of 1, alpha-phenyl-alpha (2-diethylaminoethyl) glutarimide hydrochloride on gastric secretion & gastrointestinal motility in man].
    Gastroenterologia, 1958, Volume: 90, Issue:1

    Topics: Gastric Juice; Gastrointestinal Motility; Gastrointestinal Tract; Muscle Relaxants, Central; Piperidones

1958
[Anticholinergic properties of hypnotic and anticonvulsive glutarimides].
    Helvetica physiologica et pharmacologica acta, 1958, Volume: 16, Issue:3

    Topics: Cholinergic Antagonists; Hypnotics and Sedatives; Parasympatholytics; Piperidines; Piperidones

1958
Glutarimides. V. Synthesis of 2-allyl-2-phenylglutarimide.
    Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1958, Volume: 47, Issue:12

    Topics: Glutethimide; Piperidines; Piperidones

1958
[beta-Methyl-beta-ethyl-glutarimide therapy of acute barbiturate poisoning].
    Minerva medica, 1959, Mar-03, Volume: 50, Issue:18

    Topics: Barbiturates; Humans; Piperazines; Piperidones

1959
A clinical trial with a new anticonvulsant drug, alpha-(p-aminophenyl)-alpha-ethyl glutarimide preparation 16038 (Ciba).
    The Journal of mental science, 1959, Volume: 105, Issue:439

    Topics: Anticonvulsants; Epilepsy; Piperidones

1959
Convulsant effects of mikedimide (3,3, methylethyl glutarimide) in monkeys.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1959, Volume: 101, Issue:3

    Topics: Animals; Bemegride; Central Nervous System Stimulants; Convulsants; Haplorhini; Piperidones

1959
[Something on glutarimides].
    Svensk farmaceutisk tidskrift, 1960, Nov-10, Volume: 31

    Topics: Piperidines; Piperidones

1960
The pharmacology of a new central nervous system stimulant, beta beta methyl isopropyl glutarimide.
    Archives internationales de pharmacodynamie et de therapie, 1960, Sep-01, Volume: 127

    Topics: Central Nervous System Stimulants; Piperidones

1960
[Glutarimide therapy of asphyxia neonatorum].
    Orvosi hetilap, 1960, Dec-25, Volume: 101

    Topics: Asphyxia Neonatorum; Central Nervous System Stimulants; Humans; Infant, Newborn; Piperidones

1960
The use of alpha-ethyl-alpha-phenyl-glutarimide (Doriden) as a motion sickness preventive.
    Current therapeutic research, clinical and experimental, 1961, Volume: 3

    Topics: Anesthesia; Biomedical Research; Glutethimide; Humans; Hypnotics and Sedatives; Motion Sickness; Piperidones

1961
[Prevention and therapy with beta-methyl-beta-ethyl-glutarimide of fetal respiratory depression caused by barbiturates in anesthesia for cesarean section].
    Minerva ginecologica, 1959, Sep-15, Volume: 11

    Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Barbiturates; Central Nervous System Stimulants; Cesarean Section; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Piperidones; Pregnancy; Respiration; Respiratory Insufficiency

1959
[A new anti-parkinson substance: alpha-phenyl-alpha-(diethylaminoethyl)-glutarimide hydrochloride. Clinical trial].
    La Semana medica, 1960, Mar-31, Volume: 116

    Topics: Parasympatholytics; Parkinsonian Disorders; Piperidones; Salts

1960
Ethyl-methyl-glutarimide (bemegride) as activator of the electroencephalogram: a diagnostic aid in clinical EEG work.
    Arzneimittel-Forschung, 1960, Volume: 10

    Topics: Bemegride; Central Nervous System Stimulants; Electroencephalography; Epilepsy; Humans; Piperidones

1960
Pharmacological properties of thalidomide (alpha-phthalimido glutarimide), a new sedative hypnotic drug.
    British journal of pharmacology and chemotherapy, 1960, Volume: 15

    Topics: Animals; Barbiturates; Central Nervous System Depressants; Glutamates; Hypnotics and Sedatives; Mice; Piperidones; Sleep; Thalidomide; Tranquilizing Agents

1960
beta beta-Methyl iso-propyl glutarimide (NP 274) combined with photic stimulation in EEG activation.
    Electroencephalography and clinical neurophysiology, 1961, Volume: 13

    Topics: Central Nervous System Stimulants; Electroencephalography; Epilepsy; Humans; Light; Photic Stimulation; Piperidones

1961
[Comparison of the effect of 2 glutarimides in neuroleptic states].
    Medicina experimentalis : International journal of experimental medicine, 1962, Volume: 6

    Topics: Antipsychotic Agents; Electroconvulsive Therapy; Hypnotics and Sedatives; Piperidones; Psychosurgery; Psychotherapy; Psychotic Disorders

1962
[Treatment of barbituric coma with N.P.13 (methyl-ethyl-glutarimide)].
    Prensa medica argentina, 1961, Nov-10, Volume: 48

    Topics: Barbiturates; Central Nervous System Stimulants; Coma; Piperidones

1961
[Treatment of severe barbiturate poisoning with the aid of glutarimide (megimide)].
    Sovetskaia meditsina, 1961, Volume: 25

    Topics: Barbiturates; Bemegride; Central Nervous System Stimulants; Piperidones

1961
[Abnormalities caused by Contergan (thalidomide, N-phtalimido-glutarimide) in Drosophila melanogaster].
    Wiener klinische Wochenschrift, 1962, Dec-21, Volume: 74

    Topics: Animals; Congenital Abnormalities; Drosophila; Drosophila melanogaster; Piperidones; Thalidomide

1962
[Teratogenic effects of glutarimide derivatives].
    Lijecnicki vjesnik, 1962, Volume: 84

    Topics: Ectromelia; Piperidones; Thalidomide

1962
[Therapy of barbiturate poisoning with massive doses of beta-beta-methyl-ethyl-glutarimide (Eukraton)].
    Munchener medizinische Wochenschrift (1950), 1963, Jun-21, Volume: 105

    Topics: Barbiturates; Bemegride; Piperidones

1963
[Clinical experiences of TAE-13, a new anticonvulsive agent, glutarimide derivative].
    No to shinkei = Brain and nerve, 1962, Volume: 14

    Topics: Anticonvulsants; Piperidones

1962
[Treatment of severe barbiturate poisoning by beta-ethyl-beta-methyl-glutarimide (megimide-bemegride)].
    Maroc medical, 1963, Volume: 42

    Topics: Barbiturates; Bemegride; Piperidones

1963
[On the stereospecific metabolism of the optical antipodes of alpha-phenyl-alpha-ethyl-glutarimide (Doriden)].
    Archives internationales de pharmacodynamie et de therapie, 1963, Mar-01, Volume: 142

    Topics: Glucuronates; Glutethimide; Piperidines; Piperidones

1963
EFFECTS OF INTRAVENOUS ADMINISTRATION OF BETA-ETHYL-BETA-METHYL GLUTARIMIDE ON THE HAEMATIC LEVEL OF THIOPENTAL.
    Biochemical pharmacology, 1964, Volume: 13

    Topics: Administration, Intravenous; Anesthesia; Anesthesia, Intravenous; Bemegride; Blood; Pharmacology; Piperidones; Rats; Research; Sulfur Isotopes; Thiopental

1964
PHARMACOLOGICAL PROPERTIES AND TERATOGENIC ACTION OF 2-(HEXAHYDROPHTHALIMIDO) GLUTARIMIDE AND 2-PHTHALIMIDO-N-METHYLGLUTARIMIDE.
    Life sciences (1962), 1964, Volume: 3

    Topics: Abnormalities, Drug-Induced; Animals; Female; Humans; Mice; Piperidines; Piperidones; Pregnancy; Pregnancy, Animal; Rabbits; Research; Thalidomide; Toxicology

1964
SYNTHESIS OF POTENTIAL ANTINEOPLASTIC AGENTS. 33. BETA-DIKETONE ANALOGS OF THE GLUTARIMIDE ANTIBIOTICS.
    Journal of medicinal chemistry, 1964, Volume: 7

    Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Chemistry, Pharmaceutical; Ketones; Leukemia L1210; Neoplasms, Experimental; Pharmacology; Piperidines; Piperidones; Research; Sarcoma 180

1964
DERIVATIVES OF GLUTARIMIDE LIKELY TO POSSESS THERAPEUTIC ACTIVITY.
    Journal of pharmaceutical sciences, 1965, Volume: 54

    Topics: Chemistry, Pharmaceutical; Imides; Pharmacy; Piperidones; Research

1965
RF VALUES OF SOME GLUTARIMIDES.
    Journal of chromatography, 1965, Volume: 17

    Topics: Bemegride; Chromatography; Glutethimide; Imides; Piperidines; Piperidones; Research

1965
GLUTARIMIDE ANTIBIOTICS. VII. THE SYNTHESIS OF DL-NEOCYCLOHEXIMIDE AND THE DETERMINATION OF THE CYCLOHEXANONE RING STEREOCHEMISTRY OF CYCLOHEXIMIDE, ITS ISOMERS, AND INACTONE.
    Journal of the American Chemical Society, 1965, Aug-05, Volume: 87

    Topics: Anti-Bacterial Agents; Chemical Phenomena; Chemistry, Pharmaceutical; Chemistry, Physical; Cyclohexanones; Cycloheximide; Isomerism; Piperidones; Research

1965
[Clinical experience with glutethimid, a glutarimide, as soporific].
    Schweizerische medizinische Wochenschrift, 1955, Mar-26, Volume: 85, Issue:13

    Topics: Anticonvulsants; Piperidines; Piperidones; Sleep Wake Disorders

1955
[Therapy of narcotic poisoning with beta-beta-methyl-ethyl-glutarimide (megimide)].
    Ideggyogyaszati szemle, 1960, Volume: 13

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Bemegride; Central Nervous System Stimulants; Narcotics; Piperidones

1960
Bradycardia and asystole on administration of Megimide (beta, beta,-methyl-ethyl glutarimide) for electroencephal-graphic activation.
    Electroencephalography and clinical neurophysiology, 1960, Volume: 12

    Topics: Bemegride; Bradycardia; Central Nervous System Stimulants; Electroencephalography; Heart Arrest; Piperidones

1960
Glutarimides I. 3-alkyl-3-methylglutarimides.
    Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1950, Volume: 39, Issue:8

    Topics: Imides; Piperidines; Piperidones

1950
Glutarimides II. 3-methyl-3-alkyl-N-alkylglutarmides.
    Journal of the American Pharmaceutical Association. American Pharmaceutical Association, 1950, Volume: 39, Issue:8

    Topics: Humans; Piperidones

1950
Three new glutarimide alkaloids from Croton cuneatus.
    Natural product research, 2004, Volume: 18, Issue:5

    Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Croton; Humans; Magnetic Resonance Spectroscopy; Phytotherapy; Piperidones; Plant Components, Aerial; Plant Extracts

2004
The migrastatin family: discovery of potent cell migration inhibitors by chemical synthesis.
    Journal of the American Chemical Society, 2004, Sep-15, Volume: 126, Issue:36

    Topics: Alcohols; Animals; Cell Movement; Endothelium, Vascular; Humans; Ketones; Lactones; Macrolides; Mammary Neoplasms, Experimental; Mice; Piperidones; Structure-Activity Relationship

2004
Identification of 3-(acylamino)azepan-2-ones as stable broad-spectrum chemokine inhibitors resistant to metabolism in vivo.
    Journal of medicinal chemistry, 2005, Feb-10, Volume: 48, Issue:3

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Azepines; Biological Availability; Chemokines; Chemotaxis, Leukocyte; Injections, Subcutaneous; Lactams; Mice; Piperidones; Stereoisomerism; Structure-Activity Relationship; Tumor Necrosis Factor-alpha; Up-Regulation

2005
Iso-migrastatin congeners from Streptomyces platensis and generation of a glutarimide polyketide library featuring the dorrigocin, lactimidomycin, migrastatin, and NK30424 scaffolds.
    Journal of the American Chemical Society, 2005, Aug-31, Volume: 127, Issue:34

    Topics: Antibiotics, Antineoplastic; Lactones; Macrolides; Magnetic Resonance Spectroscopy; Molecular Structure; Piperidones; Streptomyces

2005
Detailed studies on the enantioselective synthesis and HPLC enantioseparation of N-protected 3-hydroxyglutarimides.
    Chirality, 2005, Volume: 17, Issue:9

    Topics: Chromatography, High Pressure Liquid; Hydroxylation; Molecular Structure; Piperidones; Stereoisomerism

2005
A versatile approach for the asymmetric syntheses of (1R,9aR)-epiquinamide and (1R,9aR)-homopumiliotoxin 223G.
    Organic letters, 2006, Mar-30, Volume: 8, Issue:7

    Topics: Alkaloids; Catalysis; Indolizines; Molecular Structure; Piperidines; Piperidones; Quinolizines; Stereoisomerism

2006
Efficient synthesis of fused bicyclic glutarimides. Its application to (+/-)-alloyohimbane and louisianin D.
    Organic letters, 2006, Jul-06, Volume: 8, Issue:14

    Topics: Allyl Compounds; Catalysis; Crystallography, X-Ray; Esters; Heterocyclic Compounds, 4 or More Rings; Molecular Conformation; Molecular Structure; Piperidones; Pyridines; Stereoisomerism

2006
Synthesis and anticonvulsant activities of N-Cbz-alpha-aminoglutarimidooxy carboxylate derivatives.
    Archives of pharmacal research, 2006, Volume: 29, Issue:6

    Topics: Animals; Anticonvulsants; Carboxylic Acids; Male; Mice; Mice, Inbred ICR; Piperidones; Seizures; Structure-Activity Relationship; Strychnine

2006
Theoretical elucidation of the rhodium-catalyzed [4 + 2] annulation reactions.
    Journal of computational chemistry, 2008, Apr-15, Volume: 29, Issue:5

    Topics: Aldehydes; Alkynes; Catalysis; Computer Simulation; Cyclization; Cyclopentanes; Isocyanates; Ligands; Models, Chemical; Molecular Structure; Piperidones; Rhodium; Stereoisomerism

2008
New lactimidomycin congeners shed insight into lactimidomycin biosynthesis in Streptomyces amphibiosporus.
    Organic letters, 2007, Dec-06, Volume: 9, Issue:25

    Topics: Biological Products; Chromatography, High Pressure Liquid; Macrolides; Molecular Structure; Piperidones; Streptomyces

2007
Solid-phase synthesis of tailed cyclic RGD peptides using glutamic acid: unexpected glutarimide formation.
    Journal of peptide science : an official publication of the European Peptide Society, 2008, Volume: 14, Issue:6

    Topics: Chromatography, High Pressure Liquid; Glutamic Acid; Oligopeptides; Peptides, Cyclic; Piperidones; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2008
Simple and facile synthesis of tetralone-spiro-glutarimides and spiro-bisglutarimides from Baylis-Hillman acetates.
    Organic & biomolecular chemistry, 2008, Mar-21, Volume: 6, Issue:6

    Topics: Acetates; Models, Molecular; Molecular Structure; Piperidones; Spiro Compounds; Tetralones

2008
Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency.
    Bioorganic & medicinal chemistry letters, 2008, Nov-15, Volume: 18, Issue:22

    Topics: Animals; Antibiotics, Antineoplastic; Cell Movement; Drug Design; Female; Humans; Macrolides; Mice; Molecular Structure; Piperidones; Structure-Activity Relationship

2008
Ultrasensitive hot-electron nanobolometers for terahertz astrophysics.
    Nature nanotechnology, 2008, Volume: 3, Issue:8

    Topics: Astronomy; Electromagnetic Fields; Electrons; Energy Transfer; Equipment Design; Hot Temperature; Nanotechnology; Niobium; Photons; Physics; Piperidones; Polymethyl Methacrylate; Sensitivity and Specificity; Silicon; Silicon Compounds; Silicon Dioxide; Surface Properties; Thermal Conductivity; Titanium

2008
Lactimidomycin, iso-migrastatin and related glutarimide-containing 12-membered macrolides are extremely potent inhibitors of cell migration.
    Journal of the American Chemical Society, 2009, Feb-04, Volume: 131, Issue:4

    Topics: Animals; Biological Products; Cell Line, Tumor; Cell Movement; Cell Survival; Humans; Macrolides; Mice; Molecular Structure; Piperidones; Structure-Activity Relationship

2009
Synthesis, structures and anti-HBV activities of derivatives of the glutarimide antibiotic cycloheximide.
    The Journal of antibiotics, 2009, Volume: 62, Issue:11

    Topics: Antiviral Agents; Cycloheximide; Hepatitis B virus; Piperidones; X-Ray Diffraction

2009
Stereoselective aldol reaction of glutarimides using pseudo C(2) symmetry.
    Organic letters, 2010, Jan-15, Volume: 12, Issue:2

    Topics: Ketones; Molecular Structure; Piperidones; Stereoisomerism

2010
Synthesis of cyclic imides from simple diols.
    Angewandte Chemie (International ed. in English), 2010, Aug-23, Volume: 49, Issue:36

    Topics: Amines; Catalysis; Cyclization; Imides; Methane; Phthalimides; Piperidones; Ruthenium; Succinimides

2010
Multifaceted modes of action for the glutarimide-containing polyketides revealed.
    Chembiochem : a European journal of chemical biology, 2010, Sep-24, Volume: 11, Issue:14

    Topics: Animals; Antineoplastic Agents; Cell Movement; Humans; Macrolides; Neoplasm Metastasis; Piperidones; Protein Biosynthesis; Streptomyces

2010
Synthesis and antiviral activities of synthetic glutarimide derivatives.
    Chemical & pharmaceutical bulletin, 2010, Volume: 58, Issue:11

    Topics: Animals; Antiviral Agents; Cell Line; Cell Survival; Chlorocebus aethiops; Coxsackievirus Infections; Enterovirus B, Human; Herpes Simplex; Herpesvirus 2, Human; Humans; Influenza A virus; Molecular Structure; Orthomyxoviridae Infections; Piperidones; Structure-Activity Relationship; Vero Cells

2010
One-electron reduction of N-chlorinated and N-brominated species is a source of radicals and bromine atom formation.
    Chemical research in toxicology, 2011, Mar-21, Volume: 24, Issue:3

    Topics: Bromates; Bromosuccinimide; Electrons; Hypochlorous Acid; Kinetics; Models, Theoretical; Oxidation-Reduction; Piperidones; Succinimides; Superoxides

2011
Inhibition of macrophage activation and suppression of graft rejection by DTCM-glutarimide, a novel piperidine derived from the antibiotic 9-methylstreptimidone.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2011, Volume: 60, Issue:9

    Topics: Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents; Cell Line; Cyclooxygenase 2; Graft Rejection; Graft Survival; Heart Transplantation; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Molecular Structure; NF-kappa B; Nitric Oxide Synthase Type II; Piperidones; Proto-Oncogene Proteins c-fos; Transcription Factor AP-1

2011
Synthesis and biological evaluation of molecular probes based on the 9-methylstreptimidone derivative DTCM-glutarimide.
    Bioorganic & medicinal chemistry letters, 2012, Jan-01, Volume: 22, Issue:1

    Topics: Animals; Biotinylation; Cell Line; Chemistry, Pharmaceutical; Drug Design; Humans; Jurkat Cells; Lipopolysaccharides; Mice; Models, Chemical; Molecular Probes; NF-kappa B; Nitric Oxide; Piperidones; Time Factors

2012
S632A3, a new glutarimide antibiotic, suppresses lipopolysaccharide-induced pro-inflammatory responses via inhibiting the activation of glycogen synthase kinase 3β.
    Experimental cell research, 2012, Dec-10, Volume: 318, Issue:20

    Topics: Animals; Anti-Bacterial Agents; Cell Line; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Inflammation Mediators; Lipopolysaccharides; Macrophages; Mice; Piperidones; Protein Kinase Inhibitors

2012
Enantiomerization mechanism of thalidomide and the role of water and hydroxide ions.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2012, Nov-05, Volume: 18, Issue:45

    Topics: Catalysis; Hydroxides; Molecular Conformation; Piperidones; Quantum Theory; Stereoisomerism; Thalidomide; Thermodynamics; Water

2012
Synthesis and asymmetric hydrogenation of (3E)-1-benzyl-3-[(2-oxopyridin-1(2H)-yl)methylidene]piperidine-2,6-dione.
    Chemical communications (Cambridge, England), 2012, Dec-21, Volume: 48, Issue:98

    Topics: Benzyl Compounds; Hydrogenation; Molecular Structure; Piperidones; Stereoisomerism

2012
Biosynthesis of 9-methylstreptimidone involves a new decarboxylative step for polyketide terminal diene formation.
    Organic letters, 2013, Mar-15, Volume: 15, Issue:6

    Topics: Anti-Bacterial Agents; Multigene Family; Piperidones; Polyenes; Polyketides; Streptomyces

2013
Volatiles, a glutarimide alkaloid and antimicrobial effects of Croton pullei (Euphorbiaceae).
    Molecules (Basel, Switzerland), 2013, Mar-12, Volume: 18, Issue:3

    Topics: Alkaloids; Anti-Infective Agents; Croton; Microbial Sensitivity Tests; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Parasitic Sensitivity Tests; Piperidones; Plant Extracts; Plant Leaves; Plant Stems; Volatile Organic Compounds

2013
Total syntheses and biological reassessment of lactimidomycin, isomigrastatin and congener glutarimide antibiotics.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2013, Jun-03, Volume: 19, Issue:23

    Topics: Anti-Bacterial Agents; Cell Movement; Female; Humans; Macrolides; Magnetic Resonance Spectroscopy; Piperidones

2013
Integration of porous coordination polymers and gold nanorods into core-shell mesoscopic composites toward light-induced molecular release.
    Journal of the American Chemical Society, 2013, Jul-31, Volume: 135, Issue:30

    Topics: Biocompatible Materials; Gold; Light; Nanocomposites; Nanofibers; Nanotubes; Photochemical Processes; Piperidones; Polymers; Porosity

2013
Spectroscopic identification of cyclic imide b2-ions from peptides containing Gln and Asn residues.
    Journal of the American Society for Mass Spectrometry, 2013, Volume: 24, Issue:8

    Topics: Amides; Asparagine; Glutamine; Imides; Lasers; Models, Molecular; Nitrogen; Oxazolone; Oxygen; Peptides; Piperazines; Piperidones; Spectrophotometry, Infrared; Succinimides; Tandem Mass Spectrometry

2013
Alienusolin, a new 4α-deoxyphorbol ester derivative, and crotonimide C, a new glutarimide alkaloid from the Kenyan Croton alienus.
    Planta medica, 2013, Volume: 79, Issue:18

    Topics: Aedes; Alkaloids; Animals; Anopheles; Anti-Infective Agents; Bacteria; Benzamides; Cell Survival; Chlorocebus aethiops; Croton; Esters; Fungi; Leishmania; Medicine, African Traditional; Molecular Structure; Phorbol Esters; Phorbols; Piperidones; Plant Leaves; Plant Roots; Plants, Medicinal; Plasmodium falciparum; Vero Cells

2013
A new glutarimide derivative from marine sponge-derived Streptomyces anulatus S71.
    Natural product research, 2014, Volume: 28, Issue:19

    Topics: Animals; Indoles; Marine Biology; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Piperidones; Polyketide Synthases; Porifera; Streptomyces

2014
Enzymatic polyketide chain branching to give substituted lactone, lactam, and glutarimide heterocycles.
    Angewandte Chemie (International ed. in English), 2014, Oct-20, Volume: 53, Issue:43

    Topics: Heterocyclic Compounds; Lactams; Lactones; Piperidones; Polyketide Synthases; Polyketides

2014
Cocrystals of the antibiotic trimethoprim with glutarimide and 3,3-dimethylglutarimide held together by three hydrogen bonds.
    Acta crystallographica. Section C, Structural chemistry, 2015, Volume: 71, Issue:Pt 1

    Topics: Anti-Bacterial Agents; Crystallography, X-Ray; Diamines; Hydrogen Bonding; Molecular Conformation; Piperidones; Trimethoprim

2015
Antiproliferative and antibacterial activity of some glutarimide derivatives.
    Journal of enzyme inhibition and medicinal chemistry, 2016, Volume: 31, Issue:6

    Topics: Anti-Bacterial Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Gram-Negative Bacteria; Gram-Positive Bacteria; HeLa Cells; Humans; K562 Cells; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Piperidones; Structure-Activity Relationship

2016
Synthesis and Biological Evaluation of Lactimidomycin and Its Analogues.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2015, Dec-21, Volume: 21, Issue:52

    Topics: Antineoplastic Agents; Biological Factors; Cell Movement; Cyclization; Humans; Lactones; Macrolides; Molecular Structure; Piperidones; Stereoisomerism; Zinc

2015
Protein Degradation via CRL4
    Journal of medicinal chemistry, 2018, 01-25, Volume: 61, Issue:2

    Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Chemistry Techniques, Synthetic; Drug Evaluation, Preclinical; Humans; Ikaros Transcription Factor; Molecular Docking Simulation; Multiple Myeloma; Peptide Hydrolases; Peptide Termination Factors; Phthalimides; Piperidones; Proteolysis; Quantitative Structure-Activity Relationship; Ubiquitin-Protein Ligases

2018
A novel cereblon modulator for targeted protein degradation.
    European journal of medicinal chemistry, 2019, Mar-15, Volume: 166

    Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line, Tumor; Female; Humans; Immunologic Factors; Mice; Peptide Hydrolases; Piperidones; Proteolysis; Ubiquitin-Protein Ligases; Xenograft Model Antitumor Assays

2019
Two new glutarimide antibiotics from Streptomyces sp. HS-NF-780.
    The Journal of antibiotics, 2019, Volume: 72, Issue:4

    Topics: Antibiotics, Antineoplastic; Cell Line, Tumor; Cell Survival; Culture Media; Cytological Techniques; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Piperidones; Spectrometry, Mass, Electrospray Ionization; Streptomyces

2019
A Novel Oral Glutarimide Derivative XC8 Suppresses Sephadex-Induced Lung Inflammation in Rats and Ovalbumin-induced Acute and Chronic Asthma in Guinea Pigs.
    Current pharmaceutical biotechnology, 2019, Volume: 20, Issue:2

    Topics: Administration, Oral; Animals; Asthma; Budesonide; Dextrans; Eosinophils; Guinea Pigs; Male; Ovalbumin; Piperidones; Pneumonia; Rats; Rats, Wistar

2019
Establishing cell painting in a smaller chemical biology lab - A report from the frontier.
    Bioorganic & medicinal chemistry, 2019, 06-15, Volume: 27, Issue:12

    Topics: Cell Line, Tumor; Fluorescent Dyes; Humans; Microscopy, Fluorescence; Molecular Probes; Piperidones; Protein Biosynthesis; Streptomyces

2019
Computational Studies on Water-Catalyzed Mechanisms for Stereoinversion of Glutarimide Intermediates Formed from Glutamic Acid Residues in Aqueous Phase.
    International journal of molecular sciences, 2019, May-15, Volume: 20, Issue:10

    Topics: Aspartic Acid; Catalysis; Drug Resistance; Glutamic Acid; Molecular Structure; Peptides; Piperidones; Proteins; Stereoisomerism; Succinimides; Water

2019
Formation of Prenylated Chalcone Xanthohumol Cocrystals: Single Crystal X-Ray Diffraction, Vibrational Spectroscopic Study Coupled with Multivariate Analysis.
    Molecules (Basel, Switzerland), 2019, Nov-21, Volume: 24, Issue:23

    Topics: Acetamides; Caffeine; Calorimetry, Differential Scanning; Chalcones; Crystallization; Crystallography, X-Ray; Flavonoids; Models, Molecular; Niacinamide; Piperidones; Prenylation; Propiophenones; Spectrum Analysis, Raman; Vibration

2019
Isolation of new streptimidone derivatives, glutarimide antibiotics from Streptomyces sp. W3002 using LC-MS-guided screening.
    The Journal of antibiotics, 2020, Volume: 73, Issue:3

    Topics: Anti-Bacterial Agents; Antineoplastic Agents; Chromatography, Liquid; Mass Spectrometry; Molecular Structure; Piperidones; Streptomyces

2020
Genomics-Driven Discovery of a Novel Glutarimide Antibiotic from Burkholderia gladioli Reveals an Unusual Polyketide Synthase Chain Release Mechanism.
    Angewandte Chemie (International ed. in English), 2020, 12-14, Volume: 59, Issue:51

    Topics: Anti-Bacterial Agents; Antineoplastic Agents; Burkholderia gladioli; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Multigene Family; Piperidones; Polyketide Synthases

2020
Spontaneous protein-protein crosslinking at glutamine and glutamic acid residues in long-lived proteins.
    The Biochemical journal, 2021, 01-29, Volume: 478, Issue:2

    Topics: Cataract; Eye Proteins; Glutamic Acid; Glutamine; Humans; Lens, Crystalline; Lysine; Middle Aged; Piperidones; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Young Adult

2021
Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria.
    Nature communications, 2021, 03-03, Volume: 12, Issue:1

    Topics: Acyltransferases; Algorithms; Arabidopsis; Bacterial Proteins; Evolution, Molecular; Genome, Bacterial; HeLa Cells; Humans; Lactones; Macrolides; Multigene Family; Phylogeny; Piperidones; Plants; Polyketide Synthases; Polyketides; Pseudomonas syringae; Xanthomonas

2021
Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs.
    Angewandte Chemie (International ed. in English), 2021, 12-13, Volume: 60, Issue:51

    Topics: Adaptor Proteins, Signal Transducing; Humans; Hydrolysis; Piperidones; Proteolysis; Ubiquitin-Protein Ligases

2021
Neuromorphic sensing of biomolecules covalently immobilised on polydimethyl glutarimide.
    Analytica chimica acta, 2023, Oct-23, Volume: 1279

    Topics: Enzymes, Immobilized; Horseradish Peroxidase; Ions; Piperidones; Sodium Dodecyl Sulfate

2023