glutarimide has been researched along with 2-piperidone in 112 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 55 (49.11) | 18.7374 |
1990's | 4 (3.57) | 18.2507 |
2000's | 19 (16.96) | 29.6817 |
2010's | 28 (25.00) | 24.3611 |
2020's | 6 (5.36) | 2.80 |
Authors | Studies |
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Jindal, MN; Patel, NB; Patel, VK | 1 |
Cook, WL; Gerald, MC; Gupta, TK; Witiak, DT | 1 |
Isono, K; Kobayashi, K; Osada, H; Sonoda, T; Ubukata, M | 1 |
Blom, W; Hierck, L; Huijmans, JG; Kelholt-Dijkman, HH; Polder-Mol, AC | 1 |
Goehring, RR; Greenwood, TD; Nwokogu, GC; Pisipati, JS; Rogers, TG; Wolfe, JF | 1 |
Knabe, J | 1 |
Lou, ZX; Marunaka, T; Matsumoto, H; Minami, Y; Otani, T; Yu, QW | 1 |
Ho, IK; Kamiyama, H; Kimura, T; Tateoka, Y; Watanabe, K; Yamamoto, I | 1 |
Jindal, MN; Patel, NB; Patel, VK; Venkatakrishna-Bhatt, H | 1 |
Johnston, GA; Nicholson, GM; Spence, I | 1 |
Shull, GE | 1 |
Cook, PF; Jahnke, K; Kautz, J; Podschun, B; Schnackerz, KD | 1 |
Bieńko, DC; Michalska, D; Morzyk, B; Wojciechowski, W | 1 |
Aboagye, FA; Lavaud, C; Massiot, G; Sam, GH | 1 |
Chang, NC; Lin, CH; Tsai, MR; Wang, YS | 1 |
MALLARD, BG; WILSON, CO | 2 |
MARSHALL, PG; VALLANCE, DK | 1 |
JALLING, O | 1 |
CASS, NM | 1 |
CASENTINI, S; MARIANI, L | 2 |
CURRY, AS | 1 |
KIMURA, ET; RICHARDS, RK | 1 |
BRAUN, V; KATTNER, W | 1 |
FLODMARK, S; PETERSEN, I; STENBERG, K | 1 |
ANDERSON, KW | 1 |
PEREMANS, J | 1 |
GROSS, F; TURRIAN, H | 1 |
MERTES, MP; WILSON, CO | 1 |
GENTILI, C | 1 |
FABISCH, W | 2 |
CHUSID, JG; KOPELOFF, LM | 1 |
LINDBLAD, CG | 1 |
MACFARLANE, AW; MCKENZIE, JS | 1 |
SZORADY, I; TAKACS, O; TOTH, G | 1 |
TYLER, DB | 1 |
CASAGLIA, G | 1 |
CASTELLUCCIO, R | 1 |
SOMERS, GF | 1 |
ANDERMANN, K | 1 |
BUESSOW, H | 1 |
CICCARELLI, TV; ESPINOSA, EF; SOTTANO, TA | 1 |
DERD', B; TIKHAMIR, N | 1 |
PARKASH, O | 1 |
BERITIC, T; MARKICEVIC, A | 1 |
GIETZ, E; STAHLER, O | 1 |
FUKUSHIMA, Y; WADA, T | 1 |
ALAMEL, P; GEOFFROY, H | 1 |
HOFFMANN, K; KEBERLE, H; RIESS, W | 1 |
CAVALIERE, R; MANNI, C; MORICCA, G | 1 |
FRATTA, I; SIGG, EB; WUEST, HM | 1 |
KEMP, RT; KRAUTH, CA; MONTGOMERY, JA; SCHAEFFER, HJ; SHEALY, YF; STRUCK, RF | 1 |
ABOU-ZEID, YM; EL-ZANFALLY, S; KHALIFA, M | 1 |
DAVIES, D; NICHOLLS, PJ | 1 |
GUROWITZ, WD; JOHNSON, F; STARKOVSKY, NA | 1 |
MULLER, P; ROHRER, F | 1 |
DUS, V; PATAKFALVI, A | 1 |
PETERSEN, I; SELLDEN, U; SODERHOLM, B; STEINWALL, O | 1 |
BENICA, WS; WILSON, CO | 2 |
Arvelo, F; Blanco, Z; Compagnone, RS; Delle Monache, F; Suárez, AI | 1 |
Danishefsky, SJ; Dorn, DC; Gaul, C; Huang, XY; Moore, MA; Njardarson, JT; Shan, D; Tong, WP; Wu, KD | 1 |
Fox, DJ; Grainger, DJ; Greig, I; Reckless, J; Warren, S; Wilbert, SM | 1 |
Jiang, H; Ju, J; Lim, SK; Seo, JW; Shen, B | 1 |
Huang, PQ; Liu, G; Liu, LX; Ruan, YP; Wei, BG; Xu, XQ; Yu, DS | 1 |
Guo, ZQ; Huang, PQ; Ruan, YP | 1 |
Chang, MY; Chang, NC; Chen, HW; Hsu, RT | 1 |
Byun, A; Choi, JW; Lee, CG; Moon, KH; Park, MS | 1 |
Geng, CY; Huang, XR; Li, JL; Li, Z; Liu, HL; Sun, CC | 1 |
Her, Y; Ju, J; Lim, SK; Seo, JW; Shen, B | 1 |
Marchant, RE; Zhu, J | 1 |
Basavaiah, D; Reddy, RJ | 1 |
Hoffmann, FM; Ju, J; Lim, SK; Peters, NR; Rajski, SR; Seo, JW; Shen, B | 2 |
Gershenson, ME; Karasik, BS; Olaya, D; Pereverzev, SV; Sergeev, AV; Wei, J | 1 |
Guo, HF; Li, YH; Li, ZR; Tao, PZ; Wang, SQ; Yi, H; Zhang, T | 1 |
Kubota, T; Watanabe, Y; Yamazaki, T | 1 |
Ghosh, SC; Hong, SH; Senthilkumar, M; Zhang, J | 1 |
Rajski, SR; Shen, B | 1 |
Gao, RM; He, WY; Ji, XY; Li, YH; Li, ZR; Meng, S; Xue, ST; Zhong, ZJ | 1 |
Anderson, RF; Davies, MJ; O'Reilly, RJ; Pattison, DI; Radom, L; Skaff, O | 1 |
Goto, R; Hirokata, G; Ishikawa, Y; Ito, A; Kaneda, A; Nishiyama, S; Ozaki, M; Shibasaki, S; Tachibana, M; Takeiri, M; Todo, S; Umezawa, K; Yamashita, K | 1 |
Ishikawa, Y; Nishiyama, S; Ota, E; Tachibana, M; Takeiri, M; Umezawa, K | 1 |
Chen, J; Deng, H; Li, D; Shen, J; Song, D; Wang, Y; Wang, Z; Xu, R; Zhang, J; Zhang, N | 1 |
Meng, Y; Tian, C; Wang, Z; Xiu, P; Zhao, W; Zhou, R | 1 |
Bisset, AA; Clarkson, GJ; Desmond, JL; Dishington, A; Ikariya, T; Jones, T; Shiibashi, A; Wills, M | 1 |
Chen, Q; Huang, H; Ju, J; Luo, M; Ma, J; Song, Y; Wang, B | 1 |
Araújo, IS; das Graças B Zoghbi, M; do S B Brasil, D; Guilhon, GM; Peixoto, RN; Santos, LS; Uetanabaro, AP | 1 |
Fürstner, A; Lam, MH; Llaveria, J; Loganzo, F; Maderna, A; Micoine, K; Persich, P | 1 |
Diring, S; Fischer, RA; Furukawa, S; Isoda, S; Kamei, K; Khaletskaya, K; Kim, F; Kitagawa, S; Meilikhov, M; Nakahama, M; Reboul, J; Tsujimoto, M | 1 |
Grzetic, J; Oomens, J | 1 |
Kerubo, LO; Langat, MK; Midiwo, JO; Ndunda, B; Wanjohi, JM | 1 |
Deng, Z; Li, Z; Lin, S; Sun, D; Sun, W; Yu, Y | 1 |
Bretschneider, T; Heine, D; Hertweck, C; Sundaram, S | 1 |
Egert, E; Ton, QC | 1 |
Drakulić, BJ; Klaus, AS; Matić, IZ; Popović-Djordjević, JB; Žižak, ŽS | 1 |
Khomutnyk, Y; Lachacz, E; Larsen, BJ; Nagorny, P; Soellner, MB; Sun, Z | 1 |
Baculi, F; Carmel, G; Condroski, K; Correa, M; Crea, T; Hansen, JD; Hickman, M; LeBrun, L; Liu, W; Lu, CC; Lu, G; Mahmoudi, A; Man, HW; Muller, G; Ruchelman, A; Vocanson, F; Zhang, W | 1 |
Cho, SY; Go, A; Ha, JD; Hwang, JY; Jeon, YU; Jo, SH; Kim, JE; Kim, JH; Kim, P; Kim, S; Kim, SA; Lee, CO; Lee, HK; Park, BC; Park, CH; Park, SG; Park, SJ | 1 |
Li, JS; Qi, H; Wang, H; Wang, JD; Xiang, WS; Xue, ZL; Zhang, H; Zhao, T; Zhao, XL | 1 |
Amelina, AN; Ferko, B; Kromova, TA; Nebolsin, VE; Proskurina, OV; Renner, A; Romanova, J; Rydlovskaya, AV; Schmutz, H | 1 |
Poulsen, TB; Svenningsen, EB | 1 |
Fukuyoshi, S; Kato, K; Kurimoto, E; Nakayoshi, T; Oda, A | 1 |
Arczewska, M; Budziak, I; Kamiński, DM | 1 |
Ahn, JS; Heo, KT; Hong, YS; Hwang, BY; Jang, JH; Jang, M; Kim, CJ; Ko, SK; Lee, B; Lee, JK; Park, CS; Park, DJ; Son, S | 1 |
Challis, GL; Dashti, Y; Jenner, M; Mahenthiralingam, E; Masschelein, J; Nakou, IT; Romero-Canelón, I | 1 |
Friedrich, MG; Schey, KL; Truscott, RJW; Wang, Z | 1 |
Burch, AY; Chevrette, MG; Helfrich, EJN; Hemmerling, F; Leopold-Messer, S; Lindow, SE; Lu, X; Medema, MH; Minas, HA; Piel, J; Ueoka, R | 1 |
Actis, M; Chai, S; Chen, T; Das, S; Fischer, M; Fu, X; Garrett, SH; Jarusiewicz, J; Jonchere, B; Keramatnia, F; Lee, RE; Li, Y; Li, Z; Mayasundari, A; Min, J; Nishiguchi, G; Nithianantham, S; Potts, PR; Rankovic, Z; Roussel, MF; Shelat, A; Slavish, J; White, SW; Yang, L; Yang, SW; Young, B; Yun, MK | 1 |
Guo, E; Le, PY; McCulloch, DG; McKenzie, DR; Murdoch, BJ; Partridge, JG; Sylvander, LA; Tran, HN | 1 |
1 review(s) available for glutarimide and 2-piperidone
Article | Year |
---|---|
[The enantioselectivity of drugs].
Topics: Barbiturates; Humans; Piperidones; Stereoisomerism; Succinimides | 1989 |
111 other study(ies) available for glutarimide and 2-piperidone
Article | Year |
---|---|
Study of some newly synthesized glutarimide compounds on skeletal muscle.
Topics: Animals; Anura; Cats; In Vitro Techniques; Muscle Contraction; Muscles; Neuromuscular Junction; Piperidines; Piperidones; Rats | 1977 |
Para-substituted N-acetyl-L(S)- and -D(R)-alpha-amino-N-phenylglutarimides. A structure-activity study of substituent effects on steroselective anticonvulsant activity.
Topics: Animals; Anticonvulsants; Ethosuximide; Male; Mice; Phenytoin; Piperidines; Piperidones; Seizures; Stereoisomerism; Structure-Activity Relationship; Trimethadione | 1976 |
Absolute configuration of epiderstatin, a new glutarimide antibiotic produced by Streptomyces pulveraceus.
Topics: Antibiotics, Antineoplastic; Circular Dichroism; Epidermal Growth Factor; Piperidones; Pyridones; Spectrophotometry, Ultraviolet; Streptomyces; X-Ray Diffraction | 1992 |
The detection of abnormal metabolites in MCAD deficiency: a new method.
Topics: Acyl-CoA Dehydrogenase; Amino Acids; Chromatography, Gas; Fatty Acid Desaturases; Glutamates; Glutamic Acid; Glutamine; Glycine; Humans; Mass Spectrometry; Piperidones | 1990 |
Synthesis and anticonvulsant activity of 2-benzylglutarimides.
Topics: Animals; Anticonvulsants; Benzyl Compounds; Mice; Piperidines; Piperidones; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1990 |
New glutarimide antibiotics, S-632-B1 and B2. II. Isolation, physico-chemical properties and chemical structure.
Topics: Antifungal Agents; Chemical Phenomena; Chemistry, Physical; Chromatography; Chromatography, High Pressure Liquid; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Conformation; Molecular Structure; Piperidones; Spectrophotometry; Stereoisomerism; Streptomyces | 1989 |
Central effects of N-substituted derivatives of 2,6-dioxopiperidine in mice.
Topics: Animals; Anticonvulsants; Bemegride; Central Nervous System; Convulsants; Hypnotics and Sedatives; Male; Mice; Piperidines; Piperidones; Sleep; Structure-Activity Relationship | 1988 |
Pharmacology of new glutarimide compounds.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Behavior, Animal; Diethylamines; Drug Evaluation, Preclinical; Female; Male; Mice; Morpholines; Piperidines; Piperidones; Structure-Activity Relationship | 1985 |
Effects of a depressant/convulsant pair of glutarimides on neuronal activity in the isolated spinal cord of the immature rat.
Topics: Amino Acids; Animals; Bemegride; Central Nervous System Depressants; Convulsants; Female; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Neurons; Piperidines; Piperidones; Rats; Rats, Inbred Strains; Reflex, Monosynaptic; Spinal Cord | 1985 |
Differential inhibition of protein synthesis: a possible biochemical mechanism of thalidomide teratogenesis.
Topics: Abnormalities, Drug-Induced; Acylation; Animals; Chemical Phenomena; Chemistry; Cycloheximide; Embryonic and Fetal Development; Gene Expression Regulation; Humans; Imides; Models, Biological; Piperidones; Polyamines; Protein Biosynthesis; Pyrimidines; Rabbits; RNA, Messenger; Teratogens; Thalidomide | 1984 |
Acid-base catalytic mechanism of dihydropyrimidinase from pH studies.
Topics: Amidohydrolases; Animals; Binding Sites; Binding, Competitive; Catalysis; Cattle; Deuterium; Hydrogen-Ion Concentration; Kinetics; Liver; Piperidones; Swine; Uracil; Zinc | 1993 |
Glutarimide: a carrier transporting drug through cell membranes.
Topics: Biological Transport; Cell Membrane; Drug Carriers; Piperidones | 2000 |
Julocrotine, a glutarimide alkaloid from Croton membranaceus.
Topics: Alkaloids; Euphorbiaceae; Humans; Piperidones; Plant Extracts; Plant Roots; Plants, Medicinal | 2000 |
An efficient approach to 3,4-disubstituted pyridin-2-ones. Formal synthesis of mappicine ketone.
Topics: Indolizines; Piperidones; Pyridones; Quinolines; Sulfones | 2003 |
Glutarimides. III. N-Alkyl and N-aryl-3,3-diethylglutarimides.
Topics: Piperidines; Piperidones | 1954 |
Anticonvulsant activity; derivatives of succinimide, glutarimide, thiazolidinedione and methanol, and some miscellaneous compounds.
Topics: Anticonvulsants; Methanol; Piperidones; Pyridines; Succinates; Succinimides; Thiazoles; Thiazolidinediones | 1954 |
Effect of betabeta-methylethyl glutarimide and amytal on rat-liver mitochondrial respiration.
Topics: Amobarbital; Animals; Barbiturates; Cell Respiration; Liver; Mitochondria; Piperidines; Piperidones; Rats | 1956 |
An electro-encephalographic study of the analeptic action of beta beta ethyl methyl glutarimide (megimide). I. Against several barbiturates and other hypnotics. II. Compared with other analeptics and convulsants.
Topics: Barbiturates; Bemegride; Central Nervous System Stimulants; Convulsants; Electroencephalography; Hypnotics and Sedatives; Piperidones | 1956 |
[Hypnotic effect of 3-phenyl-3-ethyl-glutarimide. I. Possibility of synergistic action].
Topics: Humans; Hypnotics and Sedatives; Piperidones | 1956 |
[Hypnotic effect of 3-phenyl-3-ethyl-glutarimide. II. Possibility of antagonistic action].
Topics: Hostility; Humans; Hypnotics and Sedatives; Piperidones | 1956 |
Interference by beta-methyl-beta-ethyl glutarimide in the determination of barbiturates.
Topics: Barbiturates; Central Nervous System Stimulants; Piperidones | 1957 |
A comparative study of bemegride (beta, beta-methylethyl glutarimide; NP-13; Megimide) as an analeptic in mice.
Topics: Animals; Bemegride; Central Nervous System Stimulants; Mice; Pentylenetetrazole; Picrotoxin; Piperidones | 1957 |
[High-dosed intravenous beta, beta-methylethyl glutarimide in an acute opiate-barbiturate poisoning].
Topics: Analgesics, Opioid; Barbiturates; Central Nervous System Stimulants; Piperidones | 1957 |
Glutarimides. IV. N-alkyl and N-aryl derivatives of 3-phenylglutarimide and 3-phenyl-2-methylglutarimide.
Topics: Glutethimide; Humans; Imides; Piperidines; Piperidones | 1957 |
Activation with megimide (beta, beta-methylethyl glutarimide) in electroencephalographic investigations of epileptic conditions.
Topics: Bemegride; Central Nervous System Stimulants; Electroencephalography; Epilepsy; Humans; Piperidones | 1958 |
The determination of beta-substituted glutarimides in blood: time-concentration curves after intravenous administration of two barbiturate antagonists.
Topics: Barbiturates; Central Nervous System Stimulants; Humans; Infusions, Intravenous; Piperidones | 1958 |
[Effect of 1, alpha-phenyl-alpha (2-diethylaminoethyl) glutarimide hydrochloride on gastric secretion & gastrointestinal motility in man].
Topics: Gastric Juice; Gastrointestinal Motility; Gastrointestinal Tract; Muscle Relaxants, Central; Piperidones | 1958 |
[Anticholinergic properties of hypnotic and anticonvulsive glutarimides].
Topics: Cholinergic Antagonists; Hypnotics and Sedatives; Parasympatholytics; Piperidines; Piperidones | 1958 |
Glutarimides. V. Synthesis of 2-allyl-2-phenylglutarimide.
Topics: Glutethimide; Piperidines; Piperidones | 1958 |
[beta-Methyl-beta-ethyl-glutarimide therapy of acute barbiturate poisoning].
Topics: Barbiturates; Humans; Piperazines; Piperidones | 1959 |
A clinical trial with a new anticonvulsant drug, alpha-(p-aminophenyl)-alpha-ethyl glutarimide preparation 16038 (Ciba).
Topics: Anticonvulsants; Epilepsy; Piperidones | 1959 |
Convulsant effects of mikedimide (3,3, methylethyl glutarimide) in monkeys.
Topics: Animals; Bemegride; Central Nervous System Stimulants; Convulsants; Haplorhini; Piperidones | 1959 |
[Something on glutarimides].
Topics: Piperidines; Piperidones | 1960 |
The pharmacology of a new central nervous system stimulant, beta beta methyl isopropyl glutarimide.
Topics: Central Nervous System Stimulants; Piperidones | 1960 |
[Glutarimide therapy of asphyxia neonatorum].
Topics: Asphyxia Neonatorum; Central Nervous System Stimulants; Humans; Infant, Newborn; Piperidones | 1960 |
The use of alpha-ethyl-alpha-phenyl-glutarimide (Doriden) as a motion sickness preventive.
Topics: Anesthesia; Biomedical Research; Glutethimide; Humans; Hypnotics and Sedatives; Motion Sickness; Piperidones | 1961 |
[Prevention and therapy with beta-methyl-beta-ethyl-glutarimide of fetal respiratory depression caused by barbiturates in anesthesia for cesarean section].
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Barbiturates; Central Nervous System Stimulants; Cesarean Section; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Piperidones; Pregnancy; Respiration; Respiratory Insufficiency | 1959 |
[A new anti-parkinson substance: alpha-phenyl-alpha-(diethylaminoethyl)-glutarimide hydrochloride. Clinical trial].
Topics: Parasympatholytics; Parkinsonian Disorders; Piperidones; Salts | 1960 |
Ethyl-methyl-glutarimide (bemegride) as activator of the electroencephalogram: a diagnostic aid in clinical EEG work.
Topics: Bemegride; Central Nervous System Stimulants; Electroencephalography; Epilepsy; Humans; Piperidones | 1960 |
Pharmacological properties of thalidomide (alpha-phthalimido glutarimide), a new sedative hypnotic drug.
Topics: Animals; Barbiturates; Central Nervous System Depressants; Glutamates; Hypnotics and Sedatives; Mice; Piperidones; Sleep; Thalidomide; Tranquilizing Agents | 1960 |
beta beta-Methyl iso-propyl glutarimide (NP 274) combined with photic stimulation in EEG activation.
Topics: Central Nervous System Stimulants; Electroencephalography; Epilepsy; Humans; Light; Photic Stimulation; Piperidones | 1961 |
[Comparison of the effect of 2 glutarimides in neuroleptic states].
Topics: Antipsychotic Agents; Electroconvulsive Therapy; Hypnotics and Sedatives; Piperidones; Psychosurgery; Psychotherapy; Psychotic Disorders | 1962 |
[Treatment of barbituric coma with N.P.13 (methyl-ethyl-glutarimide)].
Topics: Barbiturates; Central Nervous System Stimulants; Coma; Piperidones | 1961 |
[Treatment of severe barbiturate poisoning with the aid of glutarimide (megimide)].
Topics: Barbiturates; Bemegride; Central Nervous System Stimulants; Piperidones | 1961 |
[Abnormalities caused by Contergan (thalidomide, N-phtalimido-glutarimide) in Drosophila melanogaster].
Topics: Animals; Congenital Abnormalities; Drosophila; Drosophila melanogaster; Piperidones; Thalidomide | 1962 |
[Teratogenic effects of glutarimide derivatives].
Topics: Ectromelia; Piperidones; Thalidomide | 1962 |
[Therapy of barbiturate poisoning with massive doses of beta-beta-methyl-ethyl-glutarimide (Eukraton)].
Topics: Barbiturates; Bemegride; Piperidones | 1963 |
[Clinical experiences of TAE-13, a new anticonvulsive agent, glutarimide derivative].
Topics: Anticonvulsants; Piperidones | 1962 |
[Treatment of severe barbiturate poisoning by beta-ethyl-beta-methyl-glutarimide (megimide-bemegride)].
Topics: Barbiturates; Bemegride; Piperidones | 1963 |
[On the stereospecific metabolism of the optical antipodes of alpha-phenyl-alpha-ethyl-glutarimide (Doriden)].
Topics: Glucuronates; Glutethimide; Piperidines; Piperidones | 1963 |
EFFECTS OF INTRAVENOUS ADMINISTRATION OF BETA-ETHYL-BETA-METHYL GLUTARIMIDE ON THE HAEMATIC LEVEL OF THIOPENTAL.
Topics: Administration, Intravenous; Anesthesia; Anesthesia, Intravenous; Bemegride; Blood; Pharmacology; Piperidones; Rats; Research; Sulfur Isotopes; Thiopental | 1964 |
PHARMACOLOGICAL PROPERTIES AND TERATOGENIC ACTION OF 2-(HEXAHYDROPHTHALIMIDO) GLUTARIMIDE AND 2-PHTHALIMIDO-N-METHYLGLUTARIMIDE.
Topics: Abnormalities, Drug-Induced; Animals; Female; Humans; Mice; Piperidines; Piperidones; Pregnancy; Pregnancy, Animal; Rabbits; Research; Thalidomide; Toxicology | 1964 |
SYNTHESIS OF POTENTIAL ANTINEOPLASTIC AGENTS. 33. BETA-DIKETONE ANALOGS OF THE GLUTARIMIDE ANTIBIOTICS.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Chemistry, Pharmaceutical; Ketones; Leukemia L1210; Neoplasms, Experimental; Pharmacology; Piperidines; Piperidones; Research; Sarcoma 180 | 1964 |
DERIVATIVES OF GLUTARIMIDE LIKELY TO POSSESS THERAPEUTIC ACTIVITY.
Topics: Chemistry, Pharmaceutical; Imides; Pharmacy; Piperidones; Research | 1965 |
RF VALUES OF SOME GLUTARIMIDES.
Topics: Bemegride; Chromatography; Glutethimide; Imides; Piperidines; Piperidones; Research | 1965 |
GLUTARIMIDE ANTIBIOTICS. VII. THE SYNTHESIS OF DL-NEOCYCLOHEXIMIDE AND THE DETERMINATION OF THE CYCLOHEXANONE RING STEREOCHEMISTRY OF CYCLOHEXIMIDE, ITS ISOMERS, AND INACTONE.
Topics: Anti-Bacterial Agents; Chemical Phenomena; Chemistry, Pharmaceutical; Chemistry, Physical; Cyclohexanones; Cycloheximide; Isomerism; Piperidones; Research | 1965 |
[Clinical experience with glutethimid, a glutarimide, as soporific].
Topics: Anticonvulsants; Piperidines; Piperidones; Sleep Wake Disorders | 1955 |
[Therapy of narcotic poisoning with beta-beta-methyl-ethyl-glutarimide (megimide)].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Bemegride; Central Nervous System Stimulants; Narcotics; Piperidones | 1960 |
Bradycardia and asystole on administration of Megimide (beta, beta,-methyl-ethyl glutarimide) for electroencephal-graphic activation.
Topics: Bemegride; Bradycardia; Central Nervous System Stimulants; Electroencephalography; Heart Arrest; Piperidones | 1960 |
Glutarimides I. 3-alkyl-3-methylglutarimides.
Topics: Imides; Piperidines; Piperidones | 1950 |
Glutarimides II. 3-methyl-3-alkyl-N-alkylglutarmides.
Topics: Humans; Piperidones | 1950 |
Three new glutarimide alkaloids from Croton cuneatus.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Croton; Humans; Magnetic Resonance Spectroscopy; Phytotherapy; Piperidones; Plant Components, Aerial; Plant Extracts | 2004 |
The migrastatin family: discovery of potent cell migration inhibitors by chemical synthesis.
Topics: Alcohols; Animals; Cell Movement; Endothelium, Vascular; Humans; Ketones; Lactones; Macrolides; Mammary Neoplasms, Experimental; Mice; Piperidones; Structure-Activity Relationship | 2004 |
Identification of 3-(acylamino)azepan-2-ones as stable broad-spectrum chemokine inhibitors resistant to metabolism in vivo.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Azepines; Biological Availability; Chemokines; Chemotaxis, Leukocyte; Injections, Subcutaneous; Lactams; Mice; Piperidones; Stereoisomerism; Structure-Activity Relationship; Tumor Necrosis Factor-alpha; Up-Regulation | 2005 |
Iso-migrastatin congeners from Streptomyces platensis and generation of a glutarimide polyketide library featuring the dorrigocin, lactimidomycin, migrastatin, and NK30424 scaffolds.
Topics: Antibiotics, Antineoplastic; Lactones; Macrolides; Magnetic Resonance Spectroscopy; Molecular Structure; Piperidones; Streptomyces | 2005 |
Detailed studies on the enantioselective synthesis and HPLC enantioseparation of N-protected 3-hydroxyglutarimides.
Topics: Chromatography, High Pressure Liquid; Hydroxylation; Molecular Structure; Piperidones; Stereoisomerism | 2005 |
A versatile approach for the asymmetric syntheses of (1R,9aR)-epiquinamide and (1R,9aR)-homopumiliotoxin 223G.
Topics: Alkaloids; Catalysis; Indolizines; Molecular Structure; Piperidines; Piperidones; Quinolizines; Stereoisomerism | 2006 |
Efficient synthesis of fused bicyclic glutarimides. Its application to (+/-)-alloyohimbane and louisianin D.
Topics: Allyl Compounds; Catalysis; Crystallography, X-Ray; Esters; Heterocyclic Compounds, 4 or More Rings; Molecular Conformation; Molecular Structure; Piperidones; Pyridines; Stereoisomerism | 2006 |
Synthesis and anticonvulsant activities of N-Cbz-alpha-aminoglutarimidooxy carboxylate derivatives.
Topics: Animals; Anticonvulsants; Carboxylic Acids; Male; Mice; Mice, Inbred ICR; Piperidones; Seizures; Structure-Activity Relationship; Strychnine | 2006 |
Theoretical elucidation of the rhodium-catalyzed [4 + 2] annulation reactions.
Topics: Aldehydes; Alkynes; Catalysis; Computer Simulation; Cyclization; Cyclopentanes; Isocyanates; Ligands; Models, Chemical; Molecular Structure; Piperidones; Rhodium; Stereoisomerism | 2008 |
New lactimidomycin congeners shed insight into lactimidomycin biosynthesis in Streptomyces amphibiosporus.
Topics: Biological Products; Chromatography, High Pressure Liquid; Macrolides; Molecular Structure; Piperidones; Streptomyces | 2007 |
Solid-phase synthesis of tailed cyclic RGD peptides using glutamic acid: unexpected glutarimide formation.
Topics: Chromatography, High Pressure Liquid; Glutamic Acid; Oligopeptides; Peptides, Cyclic; Piperidones; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2008 |
Simple and facile synthesis of tetralone-spiro-glutarimides and spiro-bisglutarimides from Baylis-Hillman acetates.
Topics: Acetates; Models, Molecular; Molecular Structure; Piperidones; Spiro Compounds; Tetralones | 2008 |
Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency.
Topics: Animals; Antibiotics, Antineoplastic; Cell Movement; Drug Design; Female; Humans; Macrolides; Mice; Molecular Structure; Piperidones; Structure-Activity Relationship | 2008 |
Ultrasensitive hot-electron nanobolometers for terahertz astrophysics.
Topics: Astronomy; Electromagnetic Fields; Electrons; Energy Transfer; Equipment Design; Hot Temperature; Nanotechnology; Niobium; Photons; Physics; Piperidones; Polymethyl Methacrylate; Sensitivity and Specificity; Silicon; Silicon Compounds; Silicon Dioxide; Surface Properties; Thermal Conductivity; Titanium | 2008 |
Lactimidomycin, iso-migrastatin and related glutarimide-containing 12-membered macrolides are extremely potent inhibitors of cell migration.
Topics: Animals; Biological Products; Cell Line, Tumor; Cell Movement; Cell Survival; Humans; Macrolides; Mice; Molecular Structure; Piperidones; Structure-Activity Relationship | 2009 |
Synthesis, structures and anti-HBV activities of derivatives of the glutarimide antibiotic cycloheximide.
Topics: Antiviral Agents; Cycloheximide; Hepatitis B virus; Piperidones; X-Ray Diffraction | 2009 |
Stereoselective aldol reaction of glutarimides using pseudo C(2) symmetry.
Topics: Ketones; Molecular Structure; Piperidones; Stereoisomerism | 2010 |
Synthesis of cyclic imides from simple diols.
Topics: Amines; Catalysis; Cyclization; Imides; Methane; Phthalimides; Piperidones; Ruthenium; Succinimides | 2010 |
Multifaceted modes of action for the glutarimide-containing polyketides revealed.
Topics: Animals; Antineoplastic Agents; Cell Movement; Humans; Macrolides; Neoplasm Metastasis; Piperidones; Protein Biosynthesis; Streptomyces | 2010 |
Synthesis and antiviral activities of synthetic glutarimide derivatives.
Topics: Animals; Antiviral Agents; Cell Line; Cell Survival; Chlorocebus aethiops; Coxsackievirus Infections; Enterovirus B, Human; Herpes Simplex; Herpesvirus 2, Human; Humans; Influenza A virus; Molecular Structure; Orthomyxoviridae Infections; Piperidones; Structure-Activity Relationship; Vero Cells | 2010 |
One-electron reduction of N-chlorinated and N-brominated species is a source of radicals and bromine atom formation.
Topics: Bromates; Bromosuccinimide; Electrons; Hypochlorous Acid; Kinetics; Models, Theoretical; Oxidation-Reduction; Piperidones; Succinimides; Superoxides | 2011 |
Inhibition of macrophage activation and suppression of graft rejection by DTCM-glutarimide, a novel piperidine derived from the antibiotic 9-methylstreptimidone.
Topics: Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents; Cell Line; Cyclooxygenase 2; Graft Rejection; Graft Survival; Heart Transplantation; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Molecular Structure; NF-kappa B; Nitric Oxide Synthase Type II; Piperidones; Proto-Oncogene Proteins c-fos; Transcription Factor AP-1 | 2011 |
Synthesis and biological evaluation of molecular probes based on the 9-methylstreptimidone derivative DTCM-glutarimide.
Topics: Animals; Biotinylation; Cell Line; Chemistry, Pharmaceutical; Drug Design; Humans; Jurkat Cells; Lipopolysaccharides; Mice; Models, Chemical; Molecular Probes; NF-kappa B; Nitric Oxide; Piperidones; Time Factors | 2012 |
S632A3, a new glutarimide antibiotic, suppresses lipopolysaccharide-induced pro-inflammatory responses via inhibiting the activation of glycogen synthase kinase 3β.
Topics: Animals; Anti-Bacterial Agents; Cell Line; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Inflammation Mediators; Lipopolysaccharides; Macrophages; Mice; Piperidones; Protein Kinase Inhibitors | 2012 |
Enantiomerization mechanism of thalidomide and the role of water and hydroxide ions.
Topics: Catalysis; Hydroxides; Molecular Conformation; Piperidones; Quantum Theory; Stereoisomerism; Thalidomide; Thermodynamics; Water | 2012 |
Synthesis and asymmetric hydrogenation of (3E)-1-benzyl-3-[(2-oxopyridin-1(2H)-yl)methylidene]piperidine-2,6-dione.
Topics: Benzyl Compounds; Hydrogenation; Molecular Structure; Piperidones; Stereoisomerism | 2012 |
Biosynthesis of 9-methylstreptimidone involves a new decarboxylative step for polyketide terminal diene formation.
Topics: Anti-Bacterial Agents; Multigene Family; Piperidones; Polyenes; Polyketides; Streptomyces | 2013 |
Volatiles, a glutarimide alkaloid and antimicrobial effects of Croton pullei (Euphorbiaceae).
Topics: Alkaloids; Anti-Infective Agents; Croton; Microbial Sensitivity Tests; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Parasitic Sensitivity Tests; Piperidones; Plant Extracts; Plant Leaves; Plant Stems; Volatile Organic Compounds | 2013 |
Total syntheses and biological reassessment of lactimidomycin, isomigrastatin and congener glutarimide antibiotics.
Topics: Anti-Bacterial Agents; Cell Movement; Female; Humans; Macrolides; Magnetic Resonance Spectroscopy; Piperidones | 2013 |
Integration of porous coordination polymers and gold nanorods into core-shell mesoscopic composites toward light-induced molecular release.
Topics: Biocompatible Materials; Gold; Light; Nanocomposites; Nanofibers; Nanotubes; Photochemical Processes; Piperidones; Polymers; Porosity | 2013 |
Spectroscopic identification of cyclic imide b2-ions from peptides containing Gln and Asn residues.
Topics: Amides; Asparagine; Glutamine; Imides; Lasers; Models, Molecular; Nitrogen; Oxazolone; Oxygen; Peptides; Piperazines; Piperidones; Spectrophotometry, Infrared; Succinimides; Tandem Mass Spectrometry | 2013 |
Alienusolin, a new 4α-deoxyphorbol ester derivative, and crotonimide C, a new glutarimide alkaloid from the Kenyan Croton alienus.
Topics: Aedes; Alkaloids; Animals; Anopheles; Anti-Infective Agents; Bacteria; Benzamides; Cell Survival; Chlorocebus aethiops; Croton; Esters; Fungi; Leishmania; Medicine, African Traditional; Molecular Structure; Phorbol Esters; Phorbols; Piperidones; Plant Leaves; Plant Roots; Plants, Medicinal; Plasmodium falciparum; Vero Cells | 2013 |
A new glutarimide derivative from marine sponge-derived Streptomyces anulatus S71.
Topics: Animals; Indoles; Marine Biology; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Piperidones; Polyketide Synthases; Porifera; Streptomyces | 2014 |
Enzymatic polyketide chain branching to give substituted lactone, lactam, and glutarimide heterocycles.
Topics: Heterocyclic Compounds; Lactams; Lactones; Piperidones; Polyketide Synthases; Polyketides | 2014 |
Cocrystals of the antibiotic trimethoprim with glutarimide and 3,3-dimethylglutarimide held together by three hydrogen bonds.
Topics: Anti-Bacterial Agents; Crystallography, X-Ray; Diamines; Hydrogen Bonding; Molecular Conformation; Piperidones; Trimethoprim | 2015 |
Antiproliferative and antibacterial activity of some glutarimide derivatives.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Gram-Negative Bacteria; Gram-Positive Bacteria; HeLa Cells; Humans; K562 Cells; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Piperidones; Structure-Activity Relationship | 2016 |
Synthesis and Biological Evaluation of Lactimidomycin and Its Analogues.
Topics: Antineoplastic Agents; Biological Factors; Cell Movement; Cyclization; Humans; Lactones; Macrolides; Molecular Structure; Piperidones; Stereoisomerism; Zinc | 2015 |
Protein Degradation via CRL4
Topics: Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Chemistry Techniques, Synthetic; Drug Evaluation, Preclinical; Humans; Ikaros Transcription Factor; Molecular Docking Simulation; Multiple Myeloma; Peptide Hydrolases; Peptide Termination Factors; Phthalimides; Piperidones; Proteolysis; Quantitative Structure-Activity Relationship; Ubiquitin-Protein Ligases | 2018 |
A novel cereblon modulator for targeted protein degradation.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line, Tumor; Female; Humans; Immunologic Factors; Mice; Peptide Hydrolases; Piperidones; Proteolysis; Ubiquitin-Protein Ligases; Xenograft Model Antitumor Assays | 2019 |
Two new glutarimide antibiotics from Streptomyces sp. HS-NF-780.
Topics: Antibiotics, Antineoplastic; Cell Line, Tumor; Cell Survival; Culture Media; Cytological Techniques; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Piperidones; Spectrometry, Mass, Electrospray Ionization; Streptomyces | 2019 |
A Novel Oral Glutarimide Derivative XC8 Suppresses Sephadex-Induced Lung Inflammation in Rats and Ovalbumin-induced Acute and Chronic Asthma in Guinea Pigs.
Topics: Administration, Oral; Animals; Asthma; Budesonide; Dextrans; Eosinophils; Guinea Pigs; Male; Ovalbumin; Piperidones; Pneumonia; Rats; Rats, Wistar | 2019 |
Establishing cell painting in a smaller chemical biology lab - A report from the frontier.
Topics: Cell Line, Tumor; Fluorescent Dyes; Humans; Microscopy, Fluorescence; Molecular Probes; Piperidones; Protein Biosynthesis; Streptomyces | 2019 |
Computational Studies on Water-Catalyzed Mechanisms for Stereoinversion of Glutarimide Intermediates Formed from Glutamic Acid Residues in Aqueous Phase.
Topics: Aspartic Acid; Catalysis; Drug Resistance; Glutamic Acid; Molecular Structure; Peptides; Piperidones; Proteins; Stereoisomerism; Succinimides; Water | 2019 |
Formation of Prenylated Chalcone Xanthohumol Cocrystals: Single Crystal X-Ray Diffraction, Vibrational Spectroscopic Study Coupled with Multivariate Analysis.
Topics: Acetamides; Caffeine; Calorimetry, Differential Scanning; Chalcones; Crystallization; Crystallography, X-Ray; Flavonoids; Models, Molecular; Niacinamide; Piperidones; Prenylation; Propiophenones; Spectrum Analysis, Raman; Vibration | 2019 |
Isolation of new streptimidone derivatives, glutarimide antibiotics from Streptomyces sp. W3002 using LC-MS-guided screening.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Chromatography, Liquid; Mass Spectrometry; Molecular Structure; Piperidones; Streptomyces | 2020 |
Genomics-Driven Discovery of a Novel Glutarimide Antibiotic from Burkholderia gladioli Reveals an Unusual Polyketide Synthase Chain Release Mechanism.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Burkholderia gladioli; Cell Line, Tumor; Cell Movement; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Multigene Family; Piperidones; Polyketide Synthases | 2020 |
Spontaneous protein-protein crosslinking at glutamine and glutamic acid residues in long-lived proteins.
Topics: Cataract; Eye Proteins; Glutamic Acid; Glutamine; Humans; Lens, Crystalline; Lysine; Middle Aged; Piperidones; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Young Adult | 2021 |
Evolution of combinatorial diversity in trans-acyltransferase polyketide synthase assembly lines across bacteria.
Topics: Acyltransferases; Algorithms; Arabidopsis; Bacterial Proteins; Evolution, Molecular; Genome, Bacterial; HeLa Cells; Humans; Lactones; Macrolides; Multigene Family; Phylogeny; Piperidones; Plants; Polyketide Synthases; Polyketides; Pseudomonas syringae; Xanthomonas | 2021 |
Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs.
Topics: Adaptor Proteins, Signal Transducing; Humans; Hydrolysis; Piperidones; Proteolysis; Ubiquitin-Protein Ligases | 2021 |
Neuromorphic sensing of biomolecules covalently immobilised on polydimethyl glutarimide.
Topics: Enzymes, Immobilized; Horseradish Peroxidase; Ions; Piperidones; Sodium Dodecyl Sulfate | 2023 |