Compounds > glutamine

glutamine and sirolimus

glutamine has been researched along with sirolimus in 42 studies

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (2.38)18.2507
2000's15 (35.71)29.6817
2010's20 (47.62)24.3611
2020's6 (14.29)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Low, SY; Rennie, MJ; Taylor, PM1
Komeili, A; O'Shea, EK; Powers, T; Wedaman, KP1
Benet, LZ; Christians, U; Jacobsen, W; Leibfritz, D; Litt, L; Niemann, CU; Serkova, N1
Christie, GR; Hajduch, E; Hundal, HS; Proud, CG; Taylor, PM1
Bertrand, L; Hue, L; Krause, U; Maisin, L; Rosa, M1
Bertrand, L; Hue, L; Krause, U1
Aldea, M; Colomina, N; Garí, E; Liu, Y1
Aronova, S; Chen, JC; Dilova, I; Powers, T1
Fumarola, C; Guidotti, GG; La Monica, S1
Anand, P; Bienieki, TC; Boylan, JM; Gruppuso, PA1
Cameroni, E; De Virgilio, C; Deloche, O; Dubouloz, F; Wanke, V1
Avruch, J; Lenz, G1
Dubois, E; Feller, A; Messenguy, F; Scherens, B; Vierendeels, F1
Cooper, TG; Tate, JJ1
Cooper, TG; Dubois, E; Georis, I; Tate, JJ2
Cooper, TG; Dubois, E; Feller, A; Georis, I; Tate, JJ1
Bazer, FW; Burghardt, RC; Johnson, GA; Kim, JY; Spencer, TE; Wu, G1
Hou, Y; Lei, J; Li, X; Wang, J; Wu, G; Xi, P; Yao, K; Yin, Y1
Cooper, TG; Nelson, DR; Rai, R; Tate, JJ1
Hall, MN; Jozefczuk, S; Rudroff, F; Sauer, U; Stracka, D1
Blenis, J; Csibi, A; Hoffman, GR; Li, C; Li, J; Yang, S; Yu, JJ; Zhang, E1
Marroquin-Guzman, M; Wilson, RA1
Cheng, CS; Huang, SW; Li, CY; Wang, HC; Wang, YJ1
Allen, E; Hanahan, D; Li, L; Miéville, P; Peng, MW; Saghafinia, S; Warren, CM1
Cheng, Z; Lin, M; Liu, H; Niu, H; Rikihisa, Y; Xiong, Q; Yamamoto, A1
Bai, Y; Han, X; Lin, Z; Nie, X; Qiu, M; Wang, B; Wang, S; Yuan, J; Zhang, F; Zhuang, Z1
Antonio, S; Bortoli, S; Ceballos-Picot, I; Fernández-Ramos, AA; Laurent-Puig, P; Loriot, MA; Marchetti-Laurent, C; Pallet, N; Petitgas, C; Poindessous, V1
Imai, Y; Inoue, K; Kanoh, M; Kuwahara, M; Matsuda, S; Nabe, S; Suzuki, J; Takemori, A; Takemori, N; Yamada, T; Yamashita, M; Yasukawa, M1
Bai, X; Duan, G; Guo, Q; Qi, M; Song, Z; Wan, P; Wang, J; Zhang, Y; Zou, X1
Bi, L; Du, L; Liang, X; Meng, P; Tang, B; Wang, C; Wang, YL; Wang, YS1
Adebayo Michael, AO; Calvisi, D; Chen, X; Görg, B; Häussinger, D; Ko, S; Liu, P; Liu, S; Moghe, A; Monga, JS; Monga, SP; Oertel, M; Poddar, M; Pradhan-Sundd, T; Qvartskhava, N; Ranganathan, S; Rebouissou, S; Ribback, S; Russell, JO; Singh, S; Singhi, A; Tao, J; Xu, M; Yang, H; Zucman-Rossi, J1
Morinobu, A; Nishimura, K; Okano, T; Saegusa, J; Sendo, S; Ueda, Y; Yamada, H1
Decaens, T; Perret, C1
Frank, AR; Jewell, JL; Melick, CH; Meng, D; Navlani, R; Wang, H; Yang, Q1
Bessede, E; Bodineau, C; Costa, ASH; Courtois, S; Durán, RV; Frezza, C; Murdoch, PDS; Parejo-Pérez, C; Richard, E; Rousseau, B; Sciacovelli, M; Soubeyran, P; Tomé, M; Vacher, P; Varon, C; Villar, VH1
Akella, L; Bendell, J; Emamekhoo, H; Fan, AC; Gartrell, BA; Goodman, OB; Hsieh, JJ; Hussain, A; Kalebasty, AR; Lee, CH; Liu, S; Matrana, M; McCune, S; Motzer, R; Nikolinakos, PG; Orford, K; Parmar, H; Patel, V; Percent, I; Shaheen, M; Tannir, NM; Vaishampayan, U; Zakharia, Y; Zhang, Z1
Beesabathuni, NS; Park, S; Shah, PS1
Dankó, T; Krencz, I; Mészáros, K; Moldvai, D; Pápay, J; Petővári, G; Raffay, R; Sebestyén, A; Sebestyén, E; Sztankovics, D; Végső, G; Vetlényi, E1
Broutin, J; Clément, G; Forzani, C; Ingargiola, C; Jéhanno, I; Leprince, AS; Marmagne, A; Meyer, C1

Reviews

1 review(s) available for glutamine and sirolimus

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

1 trial(s) available for glutamine and sirolimus

ArticleYear
Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2022, 08-02, Volume: 28, Issue:15

    Topics: Angiogenesis Inhibitors; Carcinoma, Renal Cell; Everolimus; Glutaminase; Glutamine; Humans; Kidney Neoplasms; Protein Kinase Inhibitors; Sirolimus

2022

Other Studies

40 other study(ies) available for glutamine and sirolimus

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Signaling elements involved in amino acid transport responses to altered muscle cell volume.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1997, Volume: 11, Issue:13

    Topics: Amino Acid Transport Systems, Basic; Amino Acids; Androstadienes; Animals; Animals, Newborn; Carrier Proteins; Cells, Cultured; Cholera Toxin; Culture Media, Conditioned; Cycloheximide; Enzyme Inhibitors; Glutamine; GTP-Binding Proteins; Intercellular Signaling Peptides and Proteins; Kinetics; Lysophospholipids; Models, Biological; Muscle, Skeletal; Osmolar Concentration; Peptides; Phosphatidylinositol 3-Kinases; Polyenes; Protein Kinase Inhibitors; Rats; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Sodium Chloride; Virulence Factors, Bordetella; Wortmannin

1997
Mechanism of metabolic control. Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors.
    The Journal of cell biology, 2000, Nov-13, Volume: 151, Issue:4

    Topics: Amino Acids; Ammonia; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Cycle Proteins; Chromosome Mapping; Citric Acid Cycle; Dimerization; DNA-Binding Proteins; Fungal Proteins; Gene Expression Regulation, Fungal; Genotype; Glutamine; Helix-Loop-Helix Motifs; Nitrogen; Open Reading Frames; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sirolimus; Transcription Factors; Urea

2000
Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain.
    British journal of pharmacology, 2001, Volume: 133, Issue:6

    Topics: Animals; Aspartic Acid; Body Weight; Brain; Cyclosporine; Drug Synergism; Everolimus; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Immunosuppressive Agents; Magnetic Resonance Spectroscopy; Mitochondria; Oxaloacetic Acid; Phosphates; Rats; Rats, Wistar; Sirolimus; Weight Gain

2001
Intracellular sensing of amino acids in Xenopus laevis oocytes stimulates p70 S6 kinase in a target of rapamycin-dependent manner.
    The Journal of biological chemistry, 2002, Mar-22, Volume: 277, Issue:12

    Topics: Alanine; Alcohols; Amino Acid Motifs; Amino Acids; Animals; Blotting, Western; Dose-Response Relationship, Drug; Glutamic Acid; Glutamine; Leucine; Oocytes; Phosphorylation; Protein Binding; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Time Factors; Tryptophan; Xenopus laevis

2002
Signalling pathways and combinatory effects of insulin and amino acids in isolated rat hepatocytes.
    European journal of biochemistry, 2002, Volume: 269, Issue:15

    Topics: Acetyl-CoA Carboxylase; Amino Acid Sequence; Amino Acids; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Glutamine; Glycogen Synthase; Hepatocytes; Insulin; Insulin Receptor Substrate Proteins; Leucine; Male; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Receptor, Insulin; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Streptozocin

2002
Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes.
    European journal of biochemistry, 2002, Volume: 269, Issue:15

    Topics: Acetyl-CoA Carboxylase; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Glutamine; Hepatocytes; Male; Marine Toxins; Multienzyme Complexes; Okadaic Acid; Oligomycins; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Ribonucleotides; Ribosomal Protein S6 Kinases; Serine; Sirolimus

2002
TOR regulates the subcellular localization of Ime1, a transcriptional activator of meiotic development in budding yeast.
    Molecular and cellular biology, 2003, Volume: 23, Issue:20

    Topics: Antibiotics, Antineoplastic; Blotting, Northern; Blotting, Western; Carbon; Cell Division; Cell Nucleus; Cyclin G; Cyclins; Cytoplasm; Flow Cytometry; Glutamine; Meiosis; Microscopy, Fluorescence; Models, Biological; Nitrogen; Nuclear Proteins; Plasmids; Promoter Regions, Genetic; Quaternary Ammonium Compounds; Saccharomyces cerevisiae Proteins; Saccharomycetales; Signal Transduction; Sirolimus; Time Factors; Transcription Factors; Transcriptional Activation

2003
Tor signaling and nutrient-based signals converge on Mks1p phosphorylation to regulate expression of Rtg1.Rtg3p-dependent target genes.
    The Journal of biological chemistry, 2004, Nov-05, Volume: 279, Issue:45

    Topics: Ammonia; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Blotting, Northern; Blotting, Western; Dimerization; DNA, Complementary; Dose-Response Relationship, Drug; Gene Deletion; Gene Expression Regulation; Genotype; Glutamic Acid; Glutamine; Humans; Microscopy, Fluorescence; Mitochondria; Models, Biological; Nitrogen; Oligonucleotide Array Sequence Analysis; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Repressor Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Sirolimus; Transcription Factors

2004
Amino acid signaling through the mammalian target of rapamycin (mTOR) pathway: Role of glutamine and of cell shrinkage.
    Journal of cellular physiology, 2005, Volume: 204, Issue:1

    Topics: Adenosine Triphosphate; Antibiotics, Antineoplastic; Cell Size; Glutamine; Humans; Jurkat Cells; Leucine; Osmotic Pressure; Protein Kinases; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Water; Water-Electrolyte Balance

2005
Effects of maternal starvation on hepatocyte proliferation in the late gestation fetal rat.
    Pediatric research, 2005, Volume: 57, Issue:2

    Topics: Animals; Apoptosis; Arginine; Body Weight; Cell Cycle; Cell Proliferation; Cyclin D; Cyclin E; Cyclins; DNA; Female; Fetal Nutrition Disorders; Flow Cytometry; Food Deprivation; Glutamine; Hepatocytes; Immunohistochemistry; Insulin; Leucine; Liver; Microscopy, Fluorescence; Pregnancy; Pregnancy, Animal; Proliferating Cell Nuclear Antigen; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Signal Transduction; Sirolimus; Time Factors

2005
The TOR and EGO protein complexes orchestrate microautophagy in yeast.
    Molecular cell, 2005, Jul-01, Volume: 19, Issue:1

    Topics: Antifungal Agents; Autophagy; Cell Membrane; Fluorescent Dyes; Fungal Proteins; Gene Deletion; Gene Expression Profiling; Glutamine; GTP-Binding Proteins; Immunoblotting; Microscopy, Fluorescence; Models, Biological; Monomeric GTP-Binding Proteins; Precipitin Tests; Protein Array Analysis; Pyridinium Compounds; Quaternary Ammonium Compounds; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Sirolimus; Time Factors; Two-Hybrid System Techniques; Vacuoles

2005
Glutamatergic regulation of the p70S6 kinase in primary mouse neurons.
    The Journal of biological chemistry, 2005, Nov-18, Volume: 280, Issue:46

    Topics: 2-Amino-5-phosphonovalerate; 4-Aminopyridine; Animals; Bicuculline; Calcium; Calcium Channels; Calcium Channels, L-Type; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dopamine; gamma-Aminobutyric Acid; Glutamine; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons; Norepinephrine; Peptide Elongation Factor 2; Phosphatidylinositol 3-Kinases; Phosphorylation; Potassium Channels; Protein Kinases; Ribosomal Protein S6 Kinases, 70-kDa; RNA, Messenger; Signal Transduction; Sirolimus; Synapses; Time Factors; TOR Serine-Threonine Kinases

2005
Identification of direct and indirect targets of the Gln3 and Gat1 activators by transcriptional profiling in response to nitrogen availability in the short and long term.
    FEMS yeast research, 2006, Volume: 6, Issue:5

    Topics: Binding Sites; GATA Transcription Factors; Gene Expression Profiling; Gene Expression Regulation, Fungal; Glutamine; Glutathione Peroxidase; Nitrogen; Oligonucleotide Array Sequence Analysis; Prions; Proline; Promoter Regions, Genetic; Repressor Proteins; Ribosomal Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sirolimus; Transcription Factors

2006
Stress-responsive Gln3 localization in Saccharomyces cerevisiae is separable from and can overwhelm nitrogen source regulation.
    The Journal of biological chemistry, 2007, Jun-22, Volume: 282, Issue:25

    Topics: Carbon; Cell Nucleus; Cytoplasm; Gene Expression Regulation, Fungal; Glutamine; Methionine Sulfoximine; Models, Biological; Nitrogen; Phosphorylation; Proline; Repressor Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Sirolimus; Sodium Chloride; Transcription Factors

2007
Tor pathway control of the nitrogen-responsive DAL5 gene bifurcates at the level of Gln3 and Gat1 regulation in Saccharomyces cerevisiae.
    The Journal of biological chemistry, 2008, Apr-04, Volume: 283, Issue:14

    Topics: Active Transport, Cell Nucleus; Antifungal Agents; Cell Cycle Proteins; Cell Nucleus; Cytoplasm; GATA Transcription Factors; Gene Expression Regulation, Fungal; Glutamine; Glutathione Peroxidase; Membrane Transport Proteins; Nitrogen; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Prions; Protein Phosphatase 2; Repressor Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sirolimus; Transcription Factors; Transcription, Genetic

2008
Rapamycin-induced Gln3 dephosphorylation is insufficient for nuclear localization: Sit4 and PP2A phosphatases are regulated and function differently.
    The Journal of biological chemistry, 2009, Jan-23, Volume: 284, Issue:4

    Topics: Active Transport, Cell Nucleus; Cell Cycle Proteins; Cytoplasm; Gene Expression Regulation, Enzymologic; Glutamine; Mutation; Nitrogen; Phosphorylation; Protein Phosphatase 2; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sirolimus

2009
Select nutrients in the ovine uterine lumen. VII. Effects of arginine, leucine, glutamine, and glucose on trophectoderm cell signaling, proliferation, and migration.
    Biology of reproduction, 2011, Volume: 84, Issue:1

    Topics: Amino Acids; Animals; Arginine; Cell Proliferation; Cells, Cultured; Chromones; Dose-Response Relationship, Drug; Ectoderm; Female; Gene Expression Regulation, Developmental; Glucose; Glutamine; Leucine; Morpholines; Pregnancy; Ribosomal Protein S6 Kinases, 90-kDa; Sheep; Signal Transduction; Sirolimus; Uterus

2011
Alpha-ketoglutarate inhibits glutamine degradation and enhances protein synthesis in intestinal porcine epithelial cells.
    Amino acids, 2012, Volume: 42, Issue:6

    Topics: Adaptor Proteins, Signal Transducing; Alanine; Animals; Animals, Newborn; Aspartic Acid; Carbon Radioisotopes; Cells, Cultured; Culture Media; Dose-Response Relationship, Drug; Epithelial Cells; Glutamine; Intestinal Mucosa; Intestines; Ketoglutaric Acids; Phosphorylation; Protein Biosynthesis; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Swine; TOR Serine-Threonine Kinases

2012
Nitrogen-responsive regulation of GATA protein family activators Gln3 and Gat1 occurs by two distinct pathways, one inhibited by rapamycin and the other by methionine sulfoximine.
    The Journal of biological chemistry, 2011, Dec-30, Volume: 286, Issue:52

    Topics: Antifungal Agents; Cell Nucleus; GATA Transcription Factors; Gene Expression Regulation, Fungal; Glutamine; Methionine Sulfoximine; Response Elements; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sirolimus; Transcription Factors

2011
gln3 mutations dissociate responses to nitrogen limitation (nitrogen catabolite repression) and rapamycin inhibition of TorC1.
    The Journal of biological chemistry, 2013, Jan-25, Volume: 288, Issue:4

    Topics: Cytoplasm; Fluorescent Antibody Technique, Indirect; GATA Transcription Factors; Gene Deletion; Glutamine; Mechanistic Target of Rapamycin Complex 1; Models, Genetic; Multiprotein Complexes; Mutation; Nitrogen; Plasmids; Protein Interaction Mapping; Protein Structure, Secondary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sirolimus; TOR Serine-Threonine Kinases; Transcription Factors; Two-Hybrid System Techniques

2013
Nitrogen source activates TOR (target of rapamycin) complex 1 via glutamine and independently of Gtr/Rag proteins.
    The Journal of biological chemistry, 2014, Sep-05, Volume: 289, Issue:36

    Topics: Ammonium Compounds; Glutamine; Immunoblotting; Leucine; Methionine Sulfoximine; Monomeric GTP-Binding Proteins; Mutation; Nitrogen; Phosphorylation; Proline; Protein Serine-Threonine Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sirolimus; Transcription Factors

2014
Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells.
    Proceedings of the National Academy of Sciences of the United States of America, 2015, Jan-06, Volume: 112, Issue:1

    Topics: Animals; Apoptosis; Benzoquinones; Cell Line, Tumor; Cell Shape; Cell Survival; Glutamate Dehydrogenase; Glutaminase; Glutamine; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Mechanistic Target of Rapamycin Complex 1; Mice; Models, Biological; Multiprotein Complexes; Oxidation-Reduction; Phenotype; Sirolimus; Small Molecule Libraries; Sulfides; Thiadiazoles; TOR Serine-Threonine Kinases; Tuberous Sclerosis; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays

2015
GATA-Dependent Glutaminolysis Drives Appressorium Formation in Magnaporthe oryzae by Suppressing TOR Inhibition of cAMP/PKA Signaling.
    PLoS pathogens, 2015, Volume: 11, Issue:4

    Topics: Antifungal Agents; Chaperonins; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Fungal Proteins; Fungal Structures; GATA4 Transcription Factor; Gene Deletion; Gene Expression Regulation, Fungal; Glutamate-Ammonia Ligase; Glutamine; Host-Pathogen Interactions; Magnaporthe; Mutation; Nitrogen Fixation; Oryza; Protein Kinase Inhibitors; Protein Subunits; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases

2015
Replication of the Shrimp Virus WSSV Depends on Glutamate-Driven Anaplerosis.
    PloS one, 2016, Volume: 11, Issue:1

    Topics: Animals; Aspartate Aminotransferases; Chromones; Citric Acid Cycle; Gene Dosage; Genome, Viral; Glutamate Dehydrogenase; Glutamic Acid; Glutaminase; Glutamine; Hemocytes; Hemolymph; Ketoglutaric Acids; Metabolomics; Morpholines; Penaeidae; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Double-Stranded; RNA, Messenger; Sirolimus; TOR Serine-Threonine Kinases; Virus Replication; White spot syndrome virus 1

2016
Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling.
    Cell reports, 2016, 05-10, Volume: 15, Issue:6

    Topics: Angiogenesis Inhibitors; Animals; Axitinib; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glucose; Glutamine; Glycolysis; Humans; Imidazoles; Indazoles; Indoles; Intestinal Neoplasms; Lactic Acid; Membrane Transport Proteins; Mice; Models, Biological; Neuroendocrine Tumors; Pancreatic Neoplasms; Pyrroles; Signal Transduction; Sirolimus; Stomach Neoplasms; Sunitinib; TOR Serine-Threonine Kinases; Up-Regulation

2016
Ehrlichia secretes Etf-1 to induce autophagy and capture nutrients for its growth through RAB5 and class III phosphatidylinositol 3-kinase.
    Autophagy, 2016, Volume: 12, Issue:11

    Topics: Adenine; Animals; Autophagosomes; Autophagy; Autophagy-Related Protein 5; Bacterial Proteins; Beclin-1; Cell Membrane; Cell Proliferation; Class III Phosphatidylinositol 3-Kinases; Dogs; Ehrlichia chaffeensis; Ehrlichiosis; Enzyme Activation; Glutamic Acid; Glutamine; Guanosine Triphosphate; HEK293 Cells; Host-Pathogen Interactions; Humans; Huntingtin Protein; Inclusion Bodies; Mutant Proteins; Protein Binding; rab5 GTP-Binding Proteins; Signal Transduction; Sirolimus; Ubiquitination

2016
Effects of nitrogen metabolism on growth and aflatoxin biosynthesis in Aspergillus flavus.
    Journal of hazardous materials, 2017, Feb-15, Volume: 324, Issue:Pt B

    Topics: Aflatoxin B1; Aspergillus flavus; Gene Expression Profiling; Gene Regulatory Networks; Glutamate-Ammonia Ligase; Glutamine; Nitrogen; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Transcriptome

2017
A comprehensive characterization of the impact of mycophenolic acid on the metabolism of Jurkat T cells.
    Scientific reports, 2017, 09-05, Volume: 7, Issue:1

    Topics: Energy Metabolism; Glucose; Glutamine; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Jurkat Cells; Mycophenolic Acid; Proto-Oncogene Proteins c-myc; Sirolimus; Transcriptome

2017
The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation.
    Nature communications, 2018, 08-17, Volume: 9, Issue:1

    Topics: Activation, Metabolic; Animals; Carbon; CD8-Positive T-Lymphocytes; Cell Proliferation; Female; Glutamine; Histones; Ketoglutaric Acids; Lymphocyte Activation; Lysine; Mechanistic Target of Rapamycin Complex 1; Metabolomics; Methylation; Mice, Inbred C57BL; Mice, Knockout; Proto-Oncogene Proteins; Sirolimus

2018
Increased Autophagy Levels Mediate Cisplatin Resistance in Cisplatin-Resistant Cells While Also Rendering Them Vulnerable to Autophagy Induction.
    BioMed research international, 2018, Volume: 2018

    Topics: Animals; Autophagy; Cell Line, Tumor; Cisplatin; DNA; Drug Resistance, Neoplasm; Glutamine; Humans; Male; Mice, Nude; Sirolimus

2018
Sirtuin 4 Depletion Promotes Hepatocellular Carcinoma Tumorigenesis Through Regulating Adenosine-Monophosphate-Activated Protein Kinase Alpha/Mammalian Target of Rapamycin Axis in Mice.
    Hepatology (Baltimore, Md.), 2019, Volume: 69, Issue:4

    Topics: Adenosine Monophosphate; AMP-Activated Protein Kinases; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Down-Regulation; Glutamine; Hep G2 Cells; Humans; Liver Neoplasms, Experimental; Mice, Knockout; Mitochondrial Proteins; Protein Serine-Threonine Kinases; Signal Transduction; Sirolimus; Sirtuins; TOR Serine-Threonine Kinases

2019
Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations.
    Cell metabolism, 2019, 05-07, Volume: 29, Issue:5

    Topics: Acetates; Animals; beta Catenin; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Survival; Child; Child, Preschool; Disease Models, Animal; Female; Glutamate-Ammonia Ligase; Glutamine; Hepatocytes; Humans; Infant; Liver Neoplasms; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Phenols; Retrospective Studies; Sirolimus; TOR Serine-Threonine Kinases; Transfection; Wnt Signaling Pathway

2019
Additive effects of inhibiting both mTOR and glutamine metabolism on the arthritis in SKG mice.
    Scientific reports, 2019, 04-23, Volume: 9, Issue:1

    Topics: Animals; Arthritis; Bone Marrow Cells; Cell Differentiation; Cell Proliferation; Dendritic Cells; Diazooxonorleucine; Female; Glutamine; Immunosuppression Therapy; Macrophages; Mice, Inbred BALB C; Myeloid-Derived Suppressor Cells; Sirolimus; Th17 Cells; TOR Serine-Threonine Kinases

2019
Mammalian Target of Rapamycin Inhibitors, New Drugs for Beta-Catenin-Mutated Hepatocellular Carcinomas?
    Hepatology (Baltimore, Md.), 2019, Volume: 70, Issue:4

    Topics: beta Catenin; Carcinoma, Hepatocellular; Glutamine; Humans; Liver Neoplasms; Mechanistic Target of Rapamycin Complex 1; Mutation; Sirolimus

2019
Glutamine and asparagine activate mTORC1 independently of Rag GTPases.
    The Journal of biological chemistry, 2020, 03-06, Volume: 295, Issue:10

    Topics: Adaptor Proteins, Signal Transducing; ADP-Ribosylation Factor 1; Amino Acids; Animals; Asparagine; Cell Cycle Proteins; Cell Line; Culture Media; Glutamine; HEK293 Cells; Humans; Lysosomes; Mechanistic Target of Rapamycin Complex 1; Mice; Monomeric GTP-Binding Proteins; Phosphorylation; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus

2020
Two parallel pathways connect glutamine metabolism and mTORC1 activity to regulate glutamoptosis.
    Nature communications, 2021, 08-10, Volume: 12, Issue:1

    Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Glutamine; HCT116 Cells; HEK293 Cells; Humans; Male; Mechanistic Target of Rapamycin Complex 1; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Signal Transduction; Sirolimus; Xenograft Model Antitumor Assays

2021
Quantitative and temporal measurement of dynamic autophagy rates.
    Autophagy, 2023, Volume: 19, Issue:4

    Topics: Autophagy; Glutamine; Humans; Lysosomes; Sirolimus; Wortmannin

2023
Metabolic Adaptation as Potential Target in Papillary Renal Cell Carcinomas Based on Their In Situ Metabolic Characteristics.
    International journal of molecular sciences, 2022, Sep-13, Volume: 23, Issue:18

    Topics: Carcinoma, Renal Cell; Citrates; Glutamine; Humans; Kidney Neoplasms; Lactates; Malates; MTOR Inhibitors; Pyruvates; RNA, Messenger; Sirolimus; TOR Serine-Threonine Kinases

2022
The Arabidopsis Target of Rapamycin kinase regulates ammonium assimilation and glutamine metabolism.
    Plant physiology, 2023, 08-03, Volume: 192, Issue:4

    Topics: Amino Acids; Ammonium Compounds; Animals; Arabidopsis; Arabidopsis Proteins; Glutamate-Ammonia Ligase; Glutamine; Plants; Saccharomyces cerevisiae; Sirolimus

2023