glutamine has been researched along with proglumide in 166 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 146 (87.95) | 18.7374 |
1990's | 19 (11.45) | 18.2507 |
2000's | 1 (0.60) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
Bouletreau, P; Motin, J; Petit, P | 1 |
Bignamini, AA; Cacioli, D; Casula, PL; Ferrante, F; Galeone, M; Moise, G | 1 |
Vasilevskaia, LS | 1 |
Lada-Jagas, R | 1 |
Fossati, C | 1 |
Kutz, K; Lindstaedt, H; Mayershofer, R; Miederer, SE | 1 |
Bennani, A | 1 |
Bignamini, AA; Casula, PL; Rovati, AL | 1 |
Sambin, P; Trepo, C | 1 |
Bali, JP; Balmes, JL; Boucard, M; Cayrol, B; Marignan, R; Pham, TN; Tubiana, M | 1 |
Kutz, K; Lindstaedt, H; Miederer, SE; Wuttke, H | 1 |
Pipitone, V | 1 |
Rovati, AL | 1 |
Bleichner, G | 1 |
Desvigne, A; Desvigne, C; Faivre, M; Vagne, M | 1 |
Suh, HH; Tseng, LF | 1 |
Bodnar, RJ; Pasternak, GW; Paul, D | 1 |
Baba, S; Fujii, M; Fujisawa, T; Hasegawa, H; Koide, M; Nakamura, T; Okabayashi, Y; Otsuki, M; Tani, S | 1 |
Nagy, I; Pap, A; Takács, T; Varró, V | 2 |
Biliotti, D; Bontempo, I; Corazziari, E; De Medici, A; Pallotta, N; Ricci, R; Torsoli, A | 1 |
Douglas, BR; Jansen, JB; Lamers, CB; Rovati, LC; Woutersen, RA | 1 |
Hashimoto, T; MacLellan, DG; Poston, GJ; Thompson, JC; Townsend, CM; Upp, JR | 1 |
Beglinger, C; Gyr, K; Hildebrand, P; Jansen, JB; Lamers, CB; Rovati, LC; Setnikar, I; Stalder, GA; Zuercher, M | 1 |
Bonato, C; De Fazio, C; Festorazzi, S; Malesci, A; Rovati, L; Setnikar, I; Tacconi, M; Valentini, A | 1 |
Baba, H; Fujimura, M; Toda, N | 1 |
Fujii, M; Itoh, H; Nakamura, T; Okabayashi, Y; Otsuki, M; Tani, S | 1 |
Douglas, BR; Jansen, JB; Jebbink, MC; Lamers, CB | 1 |
Kellstein, DE; Mayer, DJ | 1 |
Liu, Y; Xu, QZ; Zhang, J | 2 |
Jansen, JB; Jebbink, MC; Lamers, CB; Masclee, AA | 1 |
Bastié, MJ; Pradayrol, L; Scemama, JL; Seva, C; Vaysse, N | 1 |
Gabryelewicz, A; Konturek, SJ; Kulesza, E | 1 |
Beauchamp, RD; Gomez, G; Greeley, GH; Nealon, WH; Thompson, JC; Townsend, CM | 1 |
Fanali, S; Farina, A; Nardi, A; Quaglia, MG | 1 |
Chayvialle, JA; Guillaume, P; Hahne, W; Loizeau, E; Miazza, BM; Turberg, Y | 1 |
Grendell, JH; Niederau, C; Rothman, SS | 1 |
Gardner, JD; Howard, JM; Jensen, RT; Jones, SW; Murphy, RB; Schneider, LH; Trampota, M | 1 |
Johnson, LR; Tabata, K; Yamaguchi, T | 1 |
Grendell, JH; Niederau, C; Niederau, M; Williams, JA | 1 |
Gardner, JD; Jensen, RT; Jones, SW; Murphy, RB; Rovati, LA; Setnikar, I; Zhou, ZC | 1 |
Iwamoto, Y; Kuzuya, T; Yamamoto, R | 1 |
Grendell, JH; Liddle, RA; Niederau, C; Williams, JA | 1 |
Ihse, I; Larsson, L; Lilja, I; Tarpila, E | 1 |
Dobronyi, I; Papp, M; Scarpignato, C; Varga, G | 1 |
Baba, S; Fujii, M; Fujisawa, T; Koide, M; Nakamura, T; Okabayashi, Y; Otsuki, M; Tani, S | 3 |
Chang, JH; Moriyoshi, Y; Shimizu, K; Shiratori, K; Takeuchi, T; Watanabe, S | 1 |
Baba, S; Fujii, M; Fujisawa, T; Itoh, H; Nakamura, T; Okabayshi, Y; Otsuki, M; Tani, S | 1 |
Papp, M; Scarpignato, C; Varga, G | 1 |
Abe, M; Funakoshi, A; Shinozaki, H; Wakasugi, H | 1 |
Fang, XC | 1 |
Schusdziarra, V | 1 |
Csernansky, JG; Hicks, PB; Riney, SJ; Su, K; Vinogradov, S | 1 |
Adler, G; Beglinger, C; Dill, S; Meyer, B; Werth, B | 1 |
Baba, S; Inui, A; Sakatani, N | 1 |
Allescher, HD; Daniel, EE; Fox, JE; Kostolanska, F; Rovati, LA | 1 |
Dembinski, A; Jaworek, J; Konturek, PK; Konturek, SJ; Warzecha, Z | 1 |
Chisté, R; Giacovelli, G; Rovati, LC; Setnikar, I | 1 |
Fujii, K; Kishimoto, M; Miyoshi, A | 1 |
Arabatsis, P; Lehmann, KA; Schlüsener, M | 1 |
Adler, G; Arnold, R; Göke, B; Koop, I; Reinshagen, M; Rovati, LC; Schafmayer, A | 1 |
Ahrén, B; Karlsson, S | 1 |
Dionne, RA; Hargreaves, KM; Lavigne, GJ; Schmidt, EA | 1 |
Brailski, Kh; Dimitrov, B; Koparanova, A; Mendizova, A; Vladimirov, B | 1 |
Matsukura, S; Mitsukawa, T; Nakatsuru, K; Nishizono, F; Ohgo, S; Takemura, J | 1 |
Burt, S; Kerwin, JF; Kopecka, H; Lin, CW; Miller, T; Nadzan, AM; Witte, D | 1 |
de Jong, AJ; Douglas, BR; Jansen, JB; Lamers, CB; Rovati, LC; Woutersen, RA | 2 |
Brailski, Kh; Dimitrov, B; Koparandova, O; Mendizova, A; Vladimirov, B | 1 |
Crone, C; Eggstein, S; Farthmann, EH; Imdahl, A | 1 |
Bogdal, J; Konturek, JW; Konturek, SJ; Kurek, A; Oleksy, J; Rovati, L | 1 |
Bunney, BS; Chiodo, LA; Freeman, AS | 2 |
Gardiner, J; Grider, JR; Loewe, CJ; Vlahcevic, ZR | 1 |
Fukuoka, S; Fushiki, T; Iwai, K; Kondoh, M | 1 |
Ageel, AM; Parmar, NS; Tariq, M | 2 |
Smith, JP; Solomon, TE | 1 |
Vaccarino, AL; Vaccarino, FJ | 1 |
de Jong, AJ; Jansen, JB; Lamers, CB | 1 |
Ferrell, LD; Grendell, JH; Niederau, C | 1 |
Beauchamp, RD; Glass, EJ; Singh, P; Thompson, JC; Townsend, CM | 1 |
Ammon, HP; Goldfine, ID; Verspohl, EJ; Williams, JA; Wunderle, G | 1 |
Rezvani, A; Rhoads, DL; Stokes, KB; Way, EL | 1 |
Aitken, PG; Jaffe, DB; Nadler, JV | 1 |
Massei, R; Songa, V; Trazzi, R | 1 |
McCann, SM; Vijayan, E | 2 |
Goriacheva, TV; Ignatenko, LG; Karepova, ME; Vasilevskaia, LS | 1 |
Csernansky, JG; Glick, S; Mellentin, J | 1 |
Itoh, S; Katsuura, G | 1 |
Konturek, P; Konturek, SJ; Laskiewicz, J; Thor, P | 1 |
Jiang, LH; Kasser, RJ; Wang, RY | 1 |
Ammon, HP; Verspohl, EJ; Wunderle, G | 1 |
Ortalli, G; Pagnoni, B; Rovati, LC; Tiengo, M | 1 |
Funakoshi, A; Kitani, K; Miyasaka, K; Nakamura, R | 1 |
Tani, S | 1 |
Crawley, JN | 1 |
Ito, K; Iuchi, K; Nitta, M; Shimohara, K; Tsukamoto, G | 1 |
Baba, S; Inoue, T; Inui, A; Morioka, H; Oya, M; Sakatani, N | 2 |
Funakoshi, A; Ibayashi, H; Miyazaki, K; Nakano, I; Shinozaki, H | 1 |
Cieszkowski, M; Hladij, M; Konturek, SJ; Szewczyk, K; Tasler, J | 1 |
Iwasaki, A; Matsuo, Y | 1 |
Chisté, R; Makovec, F; Rovati, LC; Setnikar, I; Warrington, SJ | 1 |
Bani, M; Cereda, R; Chisté, R; Makovec, F; Pacini, MA; Revel, L; Setnikar, I | 2 |
Bani, M; Cereda, R; Chisté, R; Makovec, F; Pacini, MA; Revel, L; Rovati, LA; Rovati, LC; Setnikar, I | 2 |
Beglinger, C; Gyr, K; Hildebrand, P; Köhler, E; Setnikar, I | 1 |
Hansky, J; Smith, GC; Willis, GL | 1 |
Bani, M; Chistè, R; Makovec, F; Revel, L; Rovati, LC; Setnikar, I | 1 |
Kimura, I; Kimura, M; Kondoh, T | 1 |
Bani, M; Cereda, R; Chistè, R; Makovec, F; Pacini, MA; Revel, L; Rovati, LC | 1 |
Barthó, L; Holzer, P; Lembeck, F; Lippe, IT; Setnikar, I | 1 |
Beauchamp, RD; Le, S; Singh, P; Thompson, JC; Townsend, CM | 1 |
Kitani, K; Kurosawa, H; Miyasaka, K | 1 |
Kajiyama, G; Kishimoto, S; Kobayashi, H; Konemori, R; Kunita, T; Miyoshi, A; Okamoto, K; Shimizu, S; Takaba, N | 1 |
Hisamitsu, T; Okada, M | 1 |
Pfaus, JG; Phillips, AG | 1 |
Bareggi, SR; Bianchi, M; Mantegazza, P; Panerai, AE; Rovati, LC | 1 |
Eran, M; Faber, J; Freier, S | 1 |
Deupree, D; Hsiao, S | 1 |
Bunney, BS; Charney, DS; Glazer, WM; Heninger, GR; Innis, RB; Price, LH; Rubin, AL; Sternberg, DE | 1 |
Beauchamp, RD; Nealon, WH; Thompson, JC; Townsend, CM | 1 |
Davison, JS; Shillabeer, G | 3 |
Itoh, Z; Nakamura, T; Nakaya, M; Suzuki, T | 1 |
Kinscheck, IB; Mayer, DJ; Watkins, LR | 2 |
Miller, J; Price, C; Price, DD; Rafii, A; von der Gruen, A | 1 |
Schneider, LH | 1 |
Ambrose, FG; Autry, WL; Barbaz, BS; Gerber, R; Liebman, JM | 1 |
Baldy, WJ; Bean, AJ; Martin, GE | 1 |
Gardner, JD; Hahne, WF; Jensen, RT; Lemp, GF | 1 |
Bailey, A; Steigerwalt, RW; Williams, JA | 1 |
Akanuma, Y; Iwamoto, Y; Nakamura, R | 1 |
Asshauer, E; Rehner, M | 1 |
Baile, CA; McLaughlin, CL; Peikin, SR | 1 |
Bali, JP; Magous, R | 1 |
Guthrie, PD; Johnson, LR | 1 |
Ben-Horin, E; Ben-Horin, N; Frenk, H | 1 |
Chou, J; Costa, E; Iadarola, M; Tang, J; Yang, HY | 1 |
Caspari, J; Erckenbrecht, JF; Wienbeck, M | 1 |
Kaplita, PV; Roebuck, BD | 1 |
Caspary, WF; Lembcke, B; Lembcke, C | 1 |
Buéno, L; Fioramonti, J; Hondé, C | 1 |
Hsiao, S; Itoh, S; Katsuura, G | 1 |
Beglinger, C; Fried, M; Gyr, K; Koehler, E; Varga, L; Whitehouse, I | 1 |
Nakagawa, H; Nishimura, M; Park, JH; Urakawa, N | 1 |
Bunney, BS; Chiodo, LA | 1 |
Jansen, JB; Lamers, CB | 1 |
Belbeck, L; Collins, S; Forsyth, P; Walker, D | 1 |
Dellepiane, F; Michetti, P; Testa, R; Volpi, C | 1 |
Marunaka, T; Matsushima, E; Minami, Y; Umeno, Y | 1 |
Bignamini, AA; Casula, PL; Galeone, M; Moise, G | 1 |
Bergemann, W; Braun, HE; Consentius, K; Hirschmann, H; Marowski, B; Munck, A; Rehs, HU; Stopik, D; Wilke, G | 1 |
Di Frazzio, S; Mandalà, ML; Mazzone, O; Monello, S; Trovato, GM | 1 |
Blasi, A; Brogna, A; Catalano, F; Daniele, S; Mangiameli, A; Marletta, F; Scollo, L | 1 |
Aono, M; Moriga, M; Murakami, M; Uchino, H | 1 |
Iwaki, K; Kimura, K; Sanai, K; Umetsu, T | 1 |
21 trial(s) available for glutamine and proglumide
Article | Year |
---|---|
[Stress ulcer and acute postoperative renal insufficiency. An attempt at preventive treatment with Solcoseryl and proglumide].
Topics: Actihaemyl; Acute Kidney Injury; Adult; Aged; Female; Glutamine; Humans; Male; Middle Aged; Peptic Ulcer; Postoperative Complications; Proglumide; Stress, Physiological; Tissue Extracts | 1976 |
Double-blind clinical comparison between a gastrin-receptor antagonist, proglumide, and a histamine H2-blocker, cimetidine.
Topics: Adult; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Duodenal Ulcer; Female; Gastric Juice; Gastrins; Glutamine; Guanidines; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Proglumide; Stomach Ulcer; Time Factors | 1978 |
[Controlled clinical evaluation of the therapeutic activity of 3 antiulcer agents in peptic ulcer: carbenoxolone, proglumide and zolimidine].
Topics: Aged; Carbenoxolone; Clinical Trials as Topic; Drug Evaluation; Female; Glutamine; Glycyrrhetinic Acid; Humans; Male; Middle Aged; Peptic Ulcer; Proglumide; Pyridines; Random Allocation | 1979 |
Efficient treatment of gastric ulcer with proglumide (Milid) in outpatients (double blind trial).
Topics: Clinical Trials as Topic; Double-Blind Method; Duodenal Ulcer; Female; Glutamine; Humans; Male; Middle Aged; Proglumide; Prospective Studies; Stomach Ulcer | 1979 |
[Effective out-patient treatment of gastric ulcer with proglumide: preliminary results (author's transl)].
Topics: Adult; Aged; Ambulatory Care; Double-Blind Method; Duodenal Ulcer; Female; Gastric Acidity Determination; Gastrins; Gastroscopy; Glutamine; Humans; Male; Middle Aged; Placebos; Proglumide; Stomach Ulcer | 1979 |
Double-blind comparison of the antirheumatic activity and gastric side-effects of indomethacin used alone or in combination with a gastro-protective agent, proglumide.
Topics: Adult; Clinical Trials as Topic; Female; Glutamine; Humans; Indomethacin; Male; Middle Aged; Pepsinogens; Proglumide; Rheumatic Diseases | 1976 |
Inhibition of gastric secretion by anti-gastrinic and H2-blocking agents.
Topics: Animals; Atropine; Benzamides; Clinical Trials as Topic; Depression, Chemical; Gastric Juice; Glutamine; Guinea Pigs; Histamine Antagonists; Humans; Metiamide; Pentagastrin; Peptic Ulcer; Proglumide; Rats; Secretory Rate; Tryptophan | 1976 |
[Controlled study of the prevention of digestive hemorrhage caused by stress with proglumide].
Topics: Clinical Trials as Topic; Drug Evaluation; Glutamine; Humans; Peptic Ulcer Hemorrhage; Proglumide; Stress, Physiological | 1976 |
Oral administration of loxiglumide (CCK antagonist) inhibits postprandial gallbladder contraction without affecting gastric emptying.
Topics: Administration, Oral; Adult; Cholecystokinin; Double-Blind Method; Female; Food; Gallbladder; Gastric Emptying; Glutamine; Humans; Male; Muscle Contraction; Proglumide; Random Allocation | 1990 |
Lack of effect of the specific cholecystokinin receptor antagonist loxiglumide on cholecystokinin clearance from plasma in man.
Topics: Adult; Cholecystokinin; Female; Glutamine; Half-Life; Humans; Male; Proglumide | 1990 |
A preliminary dose-ranging trial of proglumide for the treatment of refractory schizophrenics.
Topics: Antipsychotic Agents; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Glutamine; Humans; Proglumide; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology | 1989 |
Failure of proglumide, a cholecystokinin antagonist, to potentiate clinical morphine analgesia. A randomized double-blind postoperative study using patient-controlled analgesia (PCA).
Topics: Adult; Cholecystokinin; Clinical Trials as Topic; Double-Blind Method; Drug Combinations; Drug Synergism; Female; Glutamine; Humans; Male; Middle Aged; Morphine; Pain, Postoperative; Proglumide; Random Allocation; Self Administration | 1989 |
Proglumide potentiates morphine analgesia for acute postsurgical pain.
Topics: Adolescent; Adult; Clinical Trials as Topic; Drug Synergism; Female; Glutamine; Humans; Male; Molar, Third; Morphine; Pain Measurement; Pain, Postoperative; Proglumide | 1989 |
[Treatment of peptic ulcer with milide (proglumide)].
Topics: Adult; Clinical Trials as Topic; Female; Glutamine; Humans; Male; Middle Aged; Peptic Ulcer; Proglumide; Wound Healing | 1989 |
[Potentiation of opiates by administration of baclofen and proglumide during the intraoperative period].
Topics: Adult; Baclofen; Clinical Trials as Topic; Double-Blind Method; Drug Synergism; Female; Fentanyl; Glutamine; Humans; Intraoperative Period; Male; Middle Aged; Nitric Oxide; Proglumide; Random Allocation | 1988 |
Does the cholecystokinin antagonist proglumide possess antipsychotic activity?
Topics: Adult; Cholecystokinin; Female; Glutamine; Humans; Pilot Projects; Proglumide; Schizophrenia | 1986 |
Pentagastrin induced motility pattern in the human upper gastrointestinal tract is reversed by proglumide.
Topics: Duodenum; Gastrointestinal Motility; Glutamine; Humans; Jejunum; Male; Pentagastrin; Proglumide | 1984 |
The effect of a gastrin-receptor antagonist on gastric acid secretion and serum gastrin in the Zollinger-Ellison syndrome.
Topics: Adult; Cimetidine; Female; Gastric Acid; Gastrins; Glutamine; Humans; Male; Middle Aged; Proglumide; Zollinger-Ellison Syndrome | 1983 |
[Controlled and double-blind study of the treatment of peptic ulcer with cimetidine and proglumide].
Topics: Adult; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Female; Glutamine; Guanidines; Humans; Male; Middle Aged; Peptic Ulcer; Proglumide | 1980 |
[Two-year study on incidence of ulcer recurrence following proglumide therapy. A comparative study].
Topics: Cimetidine; Duodenal Ulcer; Female; Follow-Up Studies; Glutamine; Humans; Male; Middle Aged; Proglumide; Recurrence | 1981 |
[Duodenal ulcer - multicenter double-blind study with proglumide].
Topics: Adult; Aged; Double-Blind Method; Duodenal Ulcer; Duodenoscopy; Female; Glutamine; Humans; Magnesium; Magnesium Silicates; Male; Middle Aged; Proglumide; Silicic Acid; Wound Healing | 1981 |
145 other study(ies) available for glutamine and proglumide
Article | Year |
---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
[Several new inhibitors of gastric secretion].
Topics: Animals; Benzodiazepinones; Depression, Chemical; Dogs; Gastric Juice; Gastric Mucosa; Glutamine; Glycopeptides; Histamine H2 Antagonists; Hydrogen-Ion Concentration; Peptide Hydrolases; Piperazines; Proglumide | 1978 |
[Occupational acne in carpentry workshops].
Topics: Acne Vulgaris; Glutamine; Humans; Male; Occupational Diseases; Proglumide | 1976 |
[Proglumide in peptic ulcer and in gastroduodenal pathology. Clinical, biological and endoscopic study].
Topics: Adult; Aged; Drug Evaluation; Duodenitis; Female; Gastritis; Gastrointestinal Diseases; Glutamine; Hernia, Hiatal; Humans; Male; Middle Aged; Peptic Ulcer; Proglumide | 1979 |
Pharmacokinetic approach to proglumide long-term activity.
Topics: Animals; Female; Glutamine; Half-Life; Kinetics; Models, Biological; Proglumide; Rats; Time Factors | 1979 |
[Therapeutic value of an antigastrin nonatropinic antisecretory drug in esogastroduodenal pathology].
Topics: Adult; Aged; Esophagitis; Female; Gastrins; Gastrointestinal Diseases; Glutamine; Humans; Male; Middle Aged; Proglumide | 1978 |
[Experimental study of the gastric inhibitory effect of proglumide in the rat (author's transl)].
Topics: Animals; Depression, Chemical; Gastric Juice; Gastrins; Glutamine; Male; Proglumide; Rats; Secretory Rate | 1978 |
[Action of proglumide on gastric acid secretion and motricity stimulated by pentagastrin in the non-anesthetized cat (author's transl)].
Topics: Animals; Cats; Female; Gastric Mucosa; Gastrointestinal Motility; Glutamine; Male; Pentagastrin; Proglumide | 1977 |
Differential effects of sulfated cholecystokinin octapeptide and proglumide injected intrathecally on antinociception induced by beta-endorphin and morphine administered intracerebroventricularly in mice.
Topics: Analgesics; Animals; beta-Endorphin; Glutamine; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Proglumide; Reaction Time; Sincalide | 1990 |
Proglumide selectively potentiates supraspinal mu 1 opioid analgesia in mice.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glutamine; Male; Mice; Morphine; Morphine Dependence; Narcotics; Proglumide; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1990 |
Proglumide analogues CR 1409 and CR 1392 inhibit cholecystokinin-stimulated insulin release more potently than exocrine secretion from the isolated perfused rat pancreas.
Topics: Animals; Cholecystokinin; Glutamine; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Pancreas; Proglumide; Radioimmunoassay; Rats; Rats, Inbred Strains | 1990 |
The effect of CR 1409, a potent CCK receptor antagonist, on basal and stimulated pancreatic secretion in rat.
Topics: Animals; Bicarbonates; Dose-Response Relationship, Drug; Glutamine; Male; Pancreas; Pancreatic Juice; Proglumide; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Secretory Rate; Sincalide | 1990 |
Comparison of the effect of lorglumide on pancreatic growth stimulated by camostate in rat and hamster.
Topics: Animals; Cholecystokinin; Cricetinae; DNA; Esters; Gabexate; Gelatin; Glutamine; Guanidines; Male; Mesocricetus; Organ Size; Pancreas; Proglumide; Proteins; Rats; Rats, Inbred Strains; Stimulation, Chemical; Trypsin Inhibitors | 1990 |
In vivo comparison of inhibition with proglumide and CR-1409 of cholecystokinin-induced pressure in the biliary tract of the guinea pig.
Topics: Animals; Cholecystokinin; Dose-Response Relationship, Drug; Gallbladder; Glutamine; Guinea Pigs; Male; Muscle Contraction; Pressure; Proglumide; Time Factors; Transducers | 1990 |
Effects of a cholecystokinin receptor antagonist on intestinal phase of pancreatic and biliary responses in man.
Topics: Adult; Bile Acids and Salts; Cholecystokinin; Food; Glutamine; Humans; Intestines; Male; Pancreas; Pancreatic Polypeptide; Proglumide; Receptors, Cholecystokinin | 1990 |
Effect of loxiglumide on gallbladder contractile response to cerulein and food in humans.
Topics: Adult; Ceruletide; Cholecystokinin; Dose-Response Relationship, Drug; Drug Interactions; Feeding Behavior; Gallbladder; Glutamine; Humans; Male; Muscle Contraction; Proglumide; Reference Values; Time Factors | 1990 |
Mechanism of inhibitory action of peptide YY on cholecystokinin-induced contractions of isolated dog ileum.
Topics: Animals; Cholecystokinin; Dogs; Female; Gallbladder; Glutamine; Ileum; Isometric Contraction; Male; Muscle Contraction; Peptide YY; Peptides; Proglumide; Sincalide | 1990 |
Effect of a new cholecystokinin receptor antagonist loxiglumide on acute pancreatitis in two experimental animal models.
Topics: Acute Disease; Animals; Ceruletide; Cholecystokinin; Disease Models, Animal; Glutamine; Male; Pancreatitis; Proglumide; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Taurocholic Acid | 1990 |
Effect of loxiglumide (CR-1505) on bombesin- and meal-stimulated plasma cholecystokinin in man.
Topics: Adult; Bombesin; Cholecystokinin; Female; Food; Glutamine; Humans; Male; Proglumide; Receptors, Cholecystokinin | 1990 |
Chronic administration of cholecystokinin antagonists reverses the enhancement of spinal morphine analgesia induced by acute pretreatment.
Topics: Analgesia; Animals; Cholecystokinin; Glutamine; Injections, Spinal; Male; Morphine; Proglumide; Rats; Rats, Inbred Strains; Spinal Cord | 1990 |
[Effects of cholecystokinin, gastrin and proglumide on bile secretion in rats].
Topics: Animals; Bile; Cholecystokinin; Female; Glutamine; Male; Pentagastrin; Proglumide; Rats; Rats, Inbred Strains; Secretory Rate | 1990 |
Lorglumide and loxiglumide inhibit gastrin-stimulated DNA synthesis in a rat tumoral acinar pancreatic cell line (AR42J).
Topics: Animals; DNA, Neoplasm; Gastrins; Glutamine; Ornithine Decarboxylase; Pancreatic Neoplasms; Proglumide; Rats; Receptors, Cholecystokinin; Thymidine; Tumor Cells, Cultured | 1990 |
Comparison of loxiglumide, a cholecystokinin receptor antagonist, and atropine on hormonal and meal-stimulated pancreatic secretion in man.
Topics: Adult; Atropine; Bicarbonates; Cholecystokinin; Duodenum; Eating; Food, Formulated; Glutamine; Humans; Infusions, Intravenous; Pancreas; Proglumide; Receptors, Cholecystokinin; Secretin; Secretory Rate | 1990 |
Proglumide inhibits cholecystokinin and meal-stimulated pancreatic secretion and release of pancreatic polypeptide.
Topics: Amino Acids; Animals; Cholecystokinin; Dogs; Female; Gastrins; Glutamine; Male; Neurotensin; Oleic Acid; Oleic Acids; Pancreas; Pancreatic Polypeptide; Proglumide | 1990 |
Determination of loxiglumide in pharmaceutical preparations by using capillary zone electrophoresis.
Topics: Electrophoresis; Glutamine; Proglumide; Tablets | 1990 |
Mechanism of pancreatic growth induced by pancreatico-biliary diversion in the rat. Inhibition by proglumide, benzotript, and ranitidine.
Topics: Adaptation, Physiological; Animals; Benzamides; Biliary Tract; Cholecystokinin; DNA; Gastrins; Glutamine; Male; Organ Size; Pancreas; Pancreatic Polypeptide; Proglumide; Proteins; Ranitidine; Rats; RNA; Secretin | 1985 |
Effects of proglumide on ductal and basolateral secretion of pancreatic digestive enzymes.
Topics: Amylases; Animals; Cholecystokinin; Chymotrypsinogen; Glutamine; In Vitro Techniques; Male; Methacholine Chloride; Methacholine Compounds; Pancreas; Pancreatic Ducts; Proglumide; Proteins; Rabbits; Regression Analysis | 1985 |
Proglumide analogues: potent cholecystokinin receptor antagonists.
Topics: Amylases; Animals; Glutamine; Guinea Pigs; In Vitro Techniques; Male; Mice; Pancreas; Proglumide; Rats; Receptors, Cell Surface; Receptors, Cholecystokinin; Sincalide; Structure-Activity Relationship | 1985 |
Effect of proglumide on rat pancreatic growth.
Topics: Animals; Cholecystokinin; DNA; Gastrins; Glutamine; Male; Organ Size; Pancreas; Proglumide; Proteins; Rats; Rats, Inbred Strains; RNA; Sincalide | 1985 |
New proglumide-analogue CCK receptor antagonists: very potent and selective for peripheral tissues.
Topics: Amylases; Animals; Biological Assay; Cerebral Cortex; Cholecystokinin; Glutamine; Male; Mice; Pancreas; Proglumide; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Cholecystokinin; Sincalide | 1986 |
Structural features of various proglumide-related cholecystokinin receptor antagonists.
Topics: Amylases; Animals; Cholecystokinin; Glutamine; Guinea Pigs; Kinetics; Male; Mice; Pancreas; Proglumide; Rats; Receptors, Cholecystokinin; Sincalide; Structure-Activity Relationship | 1986 |
CR-1409: a potent inhibitor of cholecystokinin-stimulated amylase release and cholecystokinin binding in rat pancreatic acini.
Topics: Amylases; Animals; Dose-Response Relationship, Drug; Glutamine; Male; N-Methylscopolamine; Pancreas; Proglumide; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Scopolamine Derivatives; Sincalide | 1987 |
Pancreatic growth: interaction of exogenous cholecystokinin, a protease inhibitor, and a cholecystokinin receptor antagonist in mice.
Topics: Amylases; Animals; Cholecystokinin; Chymotrypsinogen; Esters; Gabexate; Glutamine; Guanidines; Male; Mice; Organ Size; Pancreas; Proglumide; Protease Inhibitors; Sincalide | 1987 |
Proglumide treatment in bile-induced acute experimental pancreatitis.
Topics: Acute Disease; Amylases; Animals; Bile; Glutamine; Male; Pancreatitis; Proglumide; Rats; Rats, Inbred Strains | 1988 |
Effect of a new potent CCK antagonist, lorglumide, on caerulein- and bombesin-induced pancreatic secretion and growth in the rat.
Topics: Amylases; Anesthesia; Animals; Body Weight; Bombesin; Ceruletide; Cholecystokinin; DNA; Glutamine; In Vitro Techniques; Male; Pancreas; Proglumide; Rats; Rats, Inbred Strains; Trypsin | 1989 |
Loxiglumide. A new proglumide analog with potent cholecystokinin antagonistic activity in the rat pancreas.
Topics: Amylases; Animals; Binding, Competitive; Cholecystokinin; Dose-Response Relationship, Drug; Glutamine; Pancreas; Proglumide; Rats; Receptors, Cholecystokinin; Sincalide | 1989 |
[Inhibitory effect of CR 1409 (cholecystokinin antagonist) on pancreatic exocrine secretion in rats].
Topics: Amylases; Animals; Cholecystokinin; Glutamine; Male; Pancreas; Pancreatic Juice; Proglumide; Rats; Rats, Inbred Strains; Sincalide | 1989 |
[Inhibitory effect of a new proglumide derivative, loxiglumide, on CCK action in isolated rat pancreatic acini].
Topics: Amylases; Animals; Cholecystokinin; Glutamine; In Vitro Techniques; Male; Pancreas; Proglumide; Rats; Rats, Inbred Strains; Sincalide | 1989 |
Effect of a new cholecystokinin receptor antagonist CR 1392 on caerulein-induced acute pancreatitis in rats.
Topics: Acute Disease; Amylases; Animals; Ceruletide; Glutamine; Humans; Male; Organ Size; Pancreas; Pancreatitis; Proglumide; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin | 1989 |
Effects of a new proglumide analogue CR 1392 on pancreatic exocrine secretion in the rat.
Topics: Amylases; Animals; Cholecystokinin; Dose-Response Relationship, Drug; Glutamine; Male; Pancreas; Proglumide; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Sincalide | 1989 |
Pancreatic secretory and trophic response to caerulein in rats: effect of proglumide and lorglumide.
Topics: Amylases; Animals; Body Weight; Ceruletide; DNA; Glutamine; In Vitro Techniques; Organ Size; Pancreas; Pancreatic Juice; Proglumide; Proteins; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Trypsin | 1989 |
The inhibitory effect of CR-1409 on amylase secretion and intracellular Ca2+ mobilization in rat pancreatic acini in vitro.
Topics: Amylases; Animals; Benzofurans; Calcium; Carbachol; Ceruletide; Cytoplasm; Fluorescent Dyes; Fura-2; Gastrin-Releasing Peptide; Glutamine; In Vitro Techniques; Male; Pancreas; Peptides; Perfusion; Proglumide; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence | 1989 |
[Effect of proglumide (PGM) on bile flow and contents in humans and animals].
Topics: Adult; Aged; Animals; Bile; Cholagogues and Choleretics; Dogs; Female; Glutamine; Humans; Male; Middle Aged; Proglumide; Rats | 1989 |
[Gastrointestinal hormones and cancers of the gastrointestinal tract].
Topics: Adenocarcinoma; Animals; Cell Division; Cell Line; Colonic Neoplasms; DNA Replication; Gastrins; Glutamine; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Proglumide; Somatostatin; Tumor Cells, Cultured | 1989 |
Treatment of biliary colic with loxiglumide.
Topics: Biliary Tract Diseases; Cholecystokinin; Colic; Female; Glutamine; Humans; Male; Proglumide; Time Factors | 1989 |
[The effect of cholecystokinin antagonists on satiety induced by cholecystokinin octapeptide in dogs].
Topics: Animals; Blood-Brain Barrier; Cholecystokinin; Dogs; Eating; Glutamine; Injections, Intravenous; Injections, Intraventricular; Proglumide; Receptors, Cholecystokinin; Sincalide | 1989 |
Effect of the novel cholecystokinin receptor antagonist CR-1392 on cholecystokinin-induced antroduodenal and pyloric motor activity in vivo.
Topics: Animals; Cholecystokinin; Dogs; Duodenum; Electric Stimulation; Female; Gastrointestinal Motility; Glutamine; Male; Proglumide; Pyloric Antrum; Pylorus; Receptors, Cholecystokinin; Tetrodotoxin | 1989 |
Cholecystokinin receptor antagonism by peptidergic and non-peptidergic agents in rat pancreas.
Topics: Animals; Benzodiazepinones; Bombesin; Ceruletide; Cholecystokinin; Devazepide; DNA; Esters; Gabexate; Glutamine; Guanidines; Pancreas; Pentagastrin; Proglumide; Protease Inhibitors; Proteins; Rats; Receptors, Cholecystokinin | 1989 |
Pharmacokinetics and tolerance of repeated oral doses of loxiglumide.
Topics: Adult; Biotransformation; Cholecystokinin; Female; Glutamine; Humans; Male; Patient Compliance; Proglumide | 1989 |
[Effect of CCK on the large intestine].
Topics: Animals; Cholecystokinin; Gastrointestinal Motility; Glutamine; Intestine, Large; Male; Muscle Contraction; Muscle, Smooth; Proglumide; Rats; Rats, Inbred Strains | 1989 |
Differential effects of atropine and a cholecystokinin receptor antagonist on pancreatic secretion.
Topics: Adult; Atropine; Cholecystokinin; Dose-Response Relationship, Drug; Esters; Feedback; Gabexate; Glutamine; Guanidines; Humans; Male; Pancreas; Peptide Hydrolases; Proglumide; Protease Inhibitors; Pulse; Reference Values | 1989 |
Effects of three different cholecystokinin receptor antagonists on basal and stimulated insulin and glucagon secretion in mice.
Topics: Animals; Benzodiazepinones; Blood Glucose; Devazepide; Female; Glucagon; Glutamine; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Inbred Strains; Proglumide; Receptors, Cholecystokinin | 1989 |
Effects of atropine, proglumide, and somatostatin analogue (SMS 201-995) on bombesin-induced gallbladder contraction and CCK secretion in humans.
Topics: Adult; Atropine; Bombesin; Cholecystokinin; Gallbladder; Glutamine; Humans; Male; Muscle Contraction; Octreotide; Proglumide; Radioimmunoassay; Reference Values; Ultrasonography | 1989 |
Hybrid cholecystokinin (CCK) antagonists: new implications in the design and modification of CCK antagonists.
Topics: Benzodiazepines; Benzodiazepinones; Chemical Phenomena; Chemistry; Cholecystokinin; Devazepide; Drug Design; Glutamine; Molecular Conformation; Proglumide; Receptors, Cholecystokinin; Stereoisomerism; Structure-Activity Relationship | 1989 |
Modulation by CR-1409 (lorglumide), a cholecystokinin receptor antagonist, of trypsin inhibitor-enhanced growth of azaserine-induced putative preneoplastic lesions in rat pancreas.
Topics: Animals; Azaserine; Cholecystokinin; Esters; Gabexate; Glutamine; Guanidines; Male; Pancreatic Neoplasms; Precancerous Conditions; Proglumide; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Sincalide; Trypsin Inhibitors | 1989 |
[Treatment of peptic ulcer using proglumide (Milid)].
Topics: Adult; Chronic Disease; Drug Evaluation; Duodenal Ulcer; Female; Gastric Juice; Gastric Mucosa; Gastroscopy; Glutamine; Humans; Male; Middle Aged; Pentagastrin; Proglumide; Stomach Ulcer | 1989 |
Growth of colorectal carcinoma cells: regulation in vitro by gastrin, pentagastrin and the gastrin-receptor antagonist proglumide.
Topics: Animals; Carcinoembryonic Antigen; Carcinoma; Cell Division; Colorectal Neoplasms; Gastrins; Glutamine; Humans; Mice; Pentagastrin; Proglumide; Receptors, Cholecystokinin; Tumor Cells, Cultured | 1989 |
CCK receptor antagonism by loxiglumide and gall bladder contractions in response to cholecystokinin, sham feeding and ordinary feeding in man.
Topics: Adolescent; Adult; Cholecystokinin; Food; Gallbladder; Glutamine; Humans; Male; Muscle Contraction; Proglumide; Receptors, Cholecystokinin; Sincalide | 1989 |
[Effect of proglumide on choleresis in rats].
Topics: Animals; Bile; Cholagogues and Choleretics; Cholic Acids; Dehydrocholic Acid; Female; Glutamine; Male; Proglumide; Rats; Taurocholic Acid | 1989 |
Further studies on the specificity of proglumide as a selective cholecystokinin antagonist in the central nervous system.
Topics: Animals; Anorexia Nervosa; Antipsychotic Agents; Apomorphine; Brain; Cholecystokinin; Glutamine; Humans; Mesencephalon; Neurons; Proglumide; Receptors, Dopamine; Schizophrenia | 1985 |
Selective inhibition of pentagastrin- and cholecystokinin-stimulated exocrine secretion by proglumide.
Topics: Animals; Bethanechol; Bethanechol Compounds; Cholecystokinin; Dogs; Dose-Response Relationship, Drug; Gastric Acid; Gastric Mucosa; Glutamine; Histamine; Male; Pancreas; Pentagastrin; Proglumide; Rats; Secretin | 1985 |
Influence of neural blockages and proglumide on rat pancreatic enzyme secretion in response to intraluminal fatty acid.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Autonomic Nerve Block; Cholecystokinin; Drug Interactions; Glutamine; Hexamethonium; Hexamethonium Compounds; Male; Oleic Acid; Oleic Acids; Pancreas; Pancreatic Juice; Parasympatholytics; Proglumide; Rats; Rats, Inbred Strains; Secretory Rate; Trypsin | 1987 |
Proglumide, a cholecystokinin receptor antagonist, exacerbates alloxan-induced diabetes mellitus in Swiss mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glutamine; Insulin; Male; Mice; Proglumide; Time Factors | 1987 |
Effects of gastrin, proglumide, and somatostatin on growth of human colon cancer.
Topics: Adenocarcinoma; Animals; Cell Line; Colonic Neoplasms; DNA, Neoplasm; Gastrins; Glutamine; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Hormone-Dependent; Proglumide; Somatostatin; Tumor Cells, Cultured | 1988 |
Influence of cholecystokinin antagonist on the effects of cholecystokinin and bombesin on azaserine-induced lesions in rat pancreas.
Topics: Animals; Azaserine; Bombesin; Cholecystokinin; Glutamine; Male; Pancreas; Proglumide; Rats; Rats, Inbred Strains | 1989 |
Antagonism of cholecystokinin function in the rostral and caudal nucleus accumbens: differential effects on brain stimulation reward.
Topics: Animals; Brain; Cholecystokinin; Glutamine; Male; Nucleus Accumbens; Proglumide; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Reward; Septal Nuclei | 1989 |
The cholecystokinin receptor antagonist CR1409 increases plasma cholecystokinin in rats.
Topics: Animals; Cholecystokinin; Dose-Response Relationship, Drug; Glutamine; Male; Proglumide; Rats; Rats, Inbred Strains | 1989 |
Caerulein-induced acute necrotizing pancreatitis in mice: protective effects of proglumide, benzotript, and secretin.
Topics: Acute Disease; Animals; Benzamides; Ceruletide; Dose-Response Relationship, Drug; Glutamine; Male; Mice; Necrosis; Pancreas; Pancreatitis; Proglumide; Receptors, Cell Surface; Receptors, Cholecystokinin; Secretin; Time Factors | 1985 |
Proglumide, a gastrin receptor antagonist, inhibits growth of colon cancer and enhances survival in mice.
Topics: Adenocarcinoma; Animals; Body Weight; Cell Division; Cell Line; Colon; Colonic Neoplasms; Gastric Fundus; Gastrins; Glutamine; Mice; Organ Size; Pancreas; Proglumide; Receptors, Cell Surface | 1985 |
Proglumide (gastrin and cholecystokinin receptor antagonist) inhibits insulin secretion in vitro.
Topics: Animals; Cholecystokinin; Culture Techniques; Depression, Chemical; Female; Gastric Inhibitory Polypeptide; Glucose; Glutamine; Insulin; Insulin Secretion; Islets of Langerhans; Male; Proglumide; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Cholecystokinin; Sincalide | 1986 |
Proglumide exhibits delta opioid agonist properties.
Topics: Animals; Binding, Competitive; Electric Stimulation; Enkephalin, Leucine; Enzyme Inhibitors; Glutamine; Guinea Pigs; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Muscle, Smooth; Naloxone; Norepinephrine; Proglumide; Receptors, Opioid; Receptors, Opioid, delta; Synaptosomes | 1987 |
Electrophysiological studies on the specificity of the cholecystokinin antagonist proglumide.
Topics: Action Potentials; Animals; Apomorphine; Brain; Cerebral Cortex; Cholecystokinin; Dopamine; Enkephalin, Methionine; gamma-Aminobutyric Acid; Glutamine; Male; Neurotensin; Proglumide; Rats; Receptors, Neurotransmitter; Sodium Glutamate; Substantia Nigra | 1987 |
The effects of cholecystokinin and cholecystokinin antagonists on synaptic function in the CA1 region of the rat hippocampal slice.
Topics: Action Potentials; Animals; Benzamides; Female; Glutamine; Hippocampus; In Vitro Techniques; Proglumide; Rats; Rats, Inbred Strains; Sincalide; Sulfates; Synapses; Synaptic Transmission | 1987 |
The effects of the cholecystokinin antagonist, proglumide, on gonadotropin release in the rat.
Topics: Animals; Castration; Cholecystokinin; Female; Follicle Stimulating Hormone; Glutamine; Gonadotropins, Pituitary; Injections, Intravenous; Injections, Intraventricular; Luteinizing Hormone; Male; Proglumide; Rats; Rats, Inbred Strains | 1986 |
[Mechanism of the action of amino acids on gastric secretion].
Topics: Amino Acids; Animals; Dogs; Drug Interactions; Gastric Mucosa; Gastrins; Glutamine; Lysine; Proglumide; Secretin | 1987 |
Differential effects of proglumide on mesolimbic and nigrostriatal dopamine function.
Topics: Animals; Apomorphine; Corpus Striatum; Dopamine; Glutamine; Haloperidol; Kainic Acid; Kinetics; Limbic System; Male; Proglumide; Rats; Receptors, Dopamine; Spiperone; Stereotyped Behavior; Substantia Nigra | 1987 |
Potentiation of beta-endorphin effects by proglumide in rats.
Topics: Analgesia; Animals; beta-Endorphin; Catalepsy; Dose-Response Relationship, Drug; Drug Synergism; Endorphins; Glutamine; Humans; Male; Proglumide; Rats; Rats, Inbred Strains; Sincalide | 1985 |
The anti-CCK effect of glutaramic acid derivatives in anesthetized and conscious rats.
Topics: Anesthesia; Animals; Cholecystokinin; Glutamine; Male; Pancreas; Proglumide; Rats; Rats, Inbred Strains | 1988 |
Cholecystokinin in the regulation of intestinal motility and pancreatic secretion in dogs.
Topics: Animals; Benzodiazepinones; Bethanechol Compounds; Bicarbonates; Bombesin; Cholecystokinin; Devazepide; Dogs; Eating; Gastrins; Gastrointestinal Motility; Glutamine; Pancreatic Juice; Proglumide; Proteins; Reference Values | 1988 |
Cholecystokinin antagonist lorglumide reverses chronic haloperidol-induced effects on dopamine neurons.
Topics: Action Potentials; Animals; Dopamine; Glutamine; Haloperidol; Male; Nucleus Accumbens; Proglumide; Rats; Rats, Inbred Strains; Septal Nuclei; Sincalide; Substantia Nigra | 1988 |
Proglumide antagonizes cholecystokinin effects on plasma glucose and insulin in rats in vivo.
Topics: Animals; Blood Glucose; Cholecystokinin; Esters; Female; Gabexate; Glucose Tolerance Test; Glutamine; Guanidines; Insulin Antagonists; Male; Proglumide; Protease Inhibitors; Rats; Rats, Inbred Strains | 1988 |
[Possible potentiation of morphine analgesia by proglumide].
Topics: Adolescent; Adult; Drug Synergism; Drug Therapy, Combination; Female; Glutamine; Humans; Middle Aged; Morphine; Pain, Postoperative; Proglumide | 1988 |
Inhibitory effect of CR-1409, a competitive inhibitor of cholecystokinin, on pancreatic exocrine secretion in the conscious rat.
Topics: Animals; Bicarbonates; Cholecystokinin; Dose-Response Relationship, Drug; Female; Glutamine; Male; Pancreatic Juice; Proglumide; Proteins; Rats; Rats, Inbred Strains; Reference Values; Sincalide | 1988 |
Experimental acute pancreatitis induced by excessive doses of caerulein in rats; protective and therapeutic effects of trypsin inhibitor urinastatin and CCK receptor antagonist CR1392.
Topics: Acute Disease; Animals; Ceruletide; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamine; Glycoproteins; Kinetics; Male; Microscopy, Electron; Pancreatitis; Proglumide; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Trypsin Inhibitors | 1988 |
Attenuation of dark-induced hyperlocomotion by a cholecystokinin antagonist in the nucleus accumbens.
Topics: Animals; Cholecystokinin; Darkness; Exploratory Behavior; Glutamine; Light; Male; Motor Activity; Nucleus Accumbens; Proglumide; Rats; Rats, Inbred Strains; Reference Values; Septal Nuclei | 1988 |
Synthesis and effect on gastric secretion of several di- or tripeptides related to proglumide.
Topics: Animals; Dipeptides; Gastric Acid; Glutamine; Male; Peptides; Proglumide; Rats; Rats, Inbred Strains | 1988 |
Comparison of effects of proglumide and CR 1409, a new glutaramic acid derivative, on CCK-8-induced pancreatic polypeptide and insulin secretion in the dog.
Topics: Animals; Cholecystokinin; Dogs; Glutamine; Insulin; Insulin Secretion; Pancreatic Polypeptide; Proglumide | 1988 |
Effects of proglumide on pancreatic endocrine and exocrine function in healthy humans.
Topics: Adult; Food; Glutamine; Humans; Islets of Langerhans; Middle Aged; Pancreas; Pancreatic Function Tests; Pancreatic Polypeptide; Proglumide | 1987 |
Effect of cholecystokinin receptor antagonist on pancreatic responses to exogenous gastrin and cholecystokinin and to meal stimuli.
Topics: Animals; Cholecystokinin; Dogs; Food; Gastric Fistula; Gastrins; Glutamine; Pancreas; Pancreatic Fistula; Pancreatic Polypeptide; Proglumide; Receptors, Cholecystokinin | 1988 |
[Recent developments in drugs antagonistic to factors causing peptic ulcer--clinical efficacy and problems; gastrin receptor blockaders].
Topics: Animals; Binding, Competitive; Cimetidine; Drug Therapy, Combination; Gastric Acid; Gastrins; Glutamine; Peptic Ulcer; Proglumide; Rats; Receptors, Gastrointestinal Hormone | 1988 |
Pharmacokinetics of loxiglumide after single intravenous or oral doses in man.
Topics: Administration, Oral; Adult; Cholecystokinin; Chromatography, High Pressure Liquid; Glutamine; Humans; Infusions, Intravenous; Injections, Intravenous; Proglumide | 1988 |
Anticholecystokinin activities of loxiglumide.
Topics: Anesthesia; Animals; Ceruletide; Cholecystokinin; Dogs; Female; Gallbladder; Gastrointestinal Motility; Glutamine; Guinea Pigs; In Vitro Techniques; Male; Mice; Pancreas; Proglumide; Rabbits; Rats; Rats, Inbred Strains; Species Specificity | 1987 |
Loxiglumide protects against experimental pancreatitis.
Topics: Animals; Ceruletide; Diet; Female; Glutamine; Male; Mice; Pancreatitis; Proglumide; Rats; Rats, Inbred Strains; Taurocholic Acid | 1987 |
Pharmacological properties of lorglumide as a member of a new class of cholecystokinin antagonists.
Topics: Animals; Cholecystokinin; Dogs; Gallbladder; Glutamine; Guinea Pigs; Ileum; In Vitro Techniques; Mice; Muscle Contraction; Pancreas; Proglumide; Rats; Receptors, Cholecystokinin | 1987 |
Biological effects of a proglumide derivative as cholecystokinin antagonist in conscious dogs.
Topics: Animals; Cholecystokinin; Dogs; Dose-Response Relationship, Drug; Gastric Acid; Glutamine; Infusions, Intravenous; Pancreatic Juice; Pancreatic Polypeptide; Pentagastrin; Proglumide; Sincalide | 1987 |
Central and peripheral proglumide administration and cholecystokinin-induced satiety.
Topics: Animals; Catheterization; Cerebral Ventricles; Cholecystokinin; Drinking Behavior; Feeding Behavior; Glutamine; Hypothalamus; Injections, Intraperitoneal; Male; Organ Specificity; Proglumide; Rats; Rats, Inbred Strains; Satiation; Stereotaxic Techniques | 1986 |
Different peripheral and central antagonistic activity of new glutaramic acid derivatives on satiety induced by cholecystokinin in rats.
Topics: Animals; Dose-Response Relationship, Drug; Glutamine; Male; Proglumide; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Satiation; Sincalide | 1986 |
Proglumide peptides and CCK antagonistic action in hog duodenal circular muscle.
Topics: Animals; Cholecystokinin; Duodenum; Female; Glutamine; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth; Peptide Fragments; Proglumide; Receptors, Cholecystokinin; Structure-Activity Relationship; Swine | 1987 |
Gastric and duodenal antiulcer and cytoprotective effects of proglumide in rats.
Topics: Animals; Cell Survival; Cimetidine; Cysteamine; Duodenal Ulcer; Female; Gastric Acid; Gastric Mucosa; Glutamine; Indomethacin; Ligation; Male; Proglumide; Pylorus; Rats; Rats, Inbred Strains; Stomach Ulcer | 1987 |
Antispasmodic activity on the gallbladder of the mouse of CR 1409 (lorglumide) a potent antagonist of peripheral CCK.
Topics: Animals; Atropine; Cholecystokinin; Dose-Response Relationship, Drug; Female; Gallbladder; Glutamine; Mice; Mice, Inbred Strains; Nifedipine; Papaverine; Parasympatholytics; Proglumide | 1987 |
Evaluation of a new and potent cholecystokinin antagonist on motor responses of the guinea-pig intestine.
Topics: Animals; Cholecystokinin; Dose-Response Relationship, Drug; Electric Stimulation; Female; Glutamine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Proglumide; Receptors, Cholecystokinin; Reflex | 1987 |
Inhibition of pentagastrin-stimulated up-regulation of gastrin receptors and growth of mouse colon tumor in vivo by proglumide, a gastrin receptor antagonist.
Topics: Animals; Colon; Colonic Neoplasms; Gastrins; Glutamine; Male; Mice; Pentagastrin; Proglumide; Receptors, Cholecystokinin | 1987 |
Proglumide has access to brain and antagonizes the central satiety effect of cholecystokinin octapeptide in the dog.
Topics: Animals; Blood-Brain Barrier; Brain; Dogs; Dose-Response Relationship, Drug; Drinking Behavior; Feeding Behavior; Glutamine; Infusions, Intravenous; Injections, Intraventricular; Proglumide; Satiation; Satiety Response; Sincalide; Time Factors | 1987 |
Proglumide stimulates basal pancreatic secretion in the conscious rat.
Topics: Animals; Bile; Consciousness; Feedback; Glutamine; Male; Pancreas; Pancreatic Juice; Proglumide; Rats; Rats, Inbred Strains | 1987 |
Preventive effect of proglumide on erosive gastritis in the rat.
Topics: Animals; Gastric Mucosa; Gastrins; Gastritis; Glutamine; Male; Proglumide; Rats; Rats, Inbred Strains; Taurocholic Acid | 1987 |
[Cholecystokinin antagonist (proglumide) potentiates the inhibitory effect of morphine on micturition reflex].
Topics: Animals; Cholecystokinin; Depression, Chemical; Drug Synergism; Female; Glutamine; Morphine; Proglumide; Rats; Rats, Inbred Strains; Reflex; Urination | 1987 |
Pharmacological characterisation of a new potent and specific nonpolypeptidic cholecystokinin antagonist.
Topics: Animals; Cerebral Cortex; Cholecystokinin; Female; Gallbladder; Glutamine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Pancreas; Proglumide; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Species Specificity | 1987 |
Cholecystokinin facilitates ejaculation in male rats: blockade with proglumide and apomorphine.
Topics: Animals; Apomorphine; Cholecystokinin; Copulation; Dose-Response Relationship, Drug; Ejaculation; Glutamine; Male; Proglumide; Rats; Sexual Behavior, Animal | 1987 |
Effect of a cholecystokinin antagonist on some effects of diazepam.
Topics: Animals; Cholecystokinin; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Glutamine; Male; Mice; Mice, Inbred Strains; Motor Activity; Pentylenetetrazole; Proglumide; Seizures | 1987 |
Effect of cholecystokinin and of its antagonist, of atropine, and of food on the release of immunoglobulin A and immunoglobulin G specific antibodies in the rat intestine.
Topics: Animals; Antibody Specificity; Atropine; Cholecystokinin; Food, Formulated; Glutamine; Immunoglobulin A; Immunoglobulin G; Intestinal Mucosa; Proglumide; Rats | 1987 |
Cholecystokinin octapeptide, proglumide, and conditioned taste avoidance in rats.
Topics: Animals; Avoidance Learning; Conditioning, Psychological; Female; Glutamine; Proglumide; Rats; Sincalide; Sucrose; Taste | 1987 |
Role of cholecystokinin in canine pancreatic exocrine response to bombesin stimulation.
Topics: Animals; Bombesin; Cholecystokinin; Dogs; Drug Interactions; Glutamine; Infusions, Intravenous; Pancreas; Proglumide | 1987 |
The effects of the cholecystokinin antagonist, proglumide, on prolactin secretion in the rat.
Topics: Animals; Cholecystokinin; Female; Glutamine; Injections, Intravenous; Injections, Intraventricular; Male; Proglumide; Prolactin; Rats; Rats, Inbred Strains | 1987 |
Proglumide, a cholecystokinin antagonist, increases gastric emptying in rats.
Topics: Administration, Oral; Animals; Cholecystokinin; Eating; Gastric Acid; Gastric Emptying; Glutamine; Injections, Intraperitoneal; Injections, Intravenous; Male; Mathematics; Proglumide; Rats; Rats, Inbred Strains; Time Factors | 1987 |
[Effect of proglumide on gastrointestinal motility and gastric secretion in the conscious state].
Topics: Animals; Dogs; Gastric Acid; Gastrointestinal Motility; Glutamine; Muscle Contraction; Pentagastrin; Proglumide | 1985 |
Potentiation of morphine analgesia by the cholecystokinin antagonist proglumide.
Topics: Analgesia; Animals; Cholecystokinin; Dose-Response Relationship, Drug; Drug Synergism; Glutamine; Injections, Spinal; Male; Microinjections; Morphine; Pain; Periaqueductal Gray; Proglumide; Rats; Rats, Inbred Strains; Reaction Time; Time Factors | 1985 |
Potentiation of systemic morphine analgesia in humans by proglumide, a cholecystokinin antagonist.
Topics: Adult; Cholecystokinin; Dose-Response Relationship, Drug; Double-Blind Method; Drug Synergism; Glutamine; Humans; Injections, Intravenous; Morphine; Pain; Proglumide; Random Allocation | 1985 |
The effect of vagotomy on the increase in food intake induced by the cholecystokinin antagonist, proglumide.
Topics: Animals; Appetite; Body Weight; Cholecystokinin; Energy Intake; Glutamine; Male; Proglumide; Rats; Rats, Inbred Strains; Vagotomy | 1985 |
Cholecystokinin-8 and proglumide modulation of electrically elicited eating.
Topics: Animals; Dose-Response Relationship, Drug; Electric Stimulation; Feeding Behavior; Glutamine; Hypothalamic Area, Lateral; Male; Proglumide; Rats; Rats, Inbred Strains; Sincalide | 1985 |
Differential antagonism by proglumide of various CCK-mediated effects in mice.
Topics: Animals; Body Temperature; Cerebral Ventricles; Glutamine; Injections, Intraventricular; Male; Mice; Motor Activity; Naloxone; Proglumide; Sincalide | 1985 |
Chronic proglumide increases [3H]spiperone binding in the rat brain.
Topics: Animals; Brain Chemistry; Butyrophenones; Cholecystokinin; Corpus Striatum; Glutamine; In Vitro Techniques; Kinetics; Male; Proglumide; Rats; Rats, Inbred Strains; Receptors, Dopamine; Spiperone | 1985 |
Proglumide and benzotript: members of a different class of cholecystokinin receptor antagonists.
Topics: Amylases; Animals; Benzamides; Carbachol; Cholecystokinin; Dibutyryl Cyclic GMP; Glutamine; Guinea Pigs; Kinetics; Male; Pancreas; Proglumide; Receptors, Cell Surface; Receptors, Cholecystokinin | 1981 |
Effects of proglumide on pancreatic acinar cell function.
Topics: Amylases; Animals; Cholecystokinin; Deoxyglucose; Glutamine; Islets of Langerhans; Male; Mice; Proglumide; Receptor, Insulin; Receptors, Cell Surface; Receptors, Cholecystokinin | 1983 |
In vitro and in vivo effect of proglumide on cholecystokinin-stimulated amylase release in mouse pancreatic acini.
Topics: Amylases; Animals; Cholecystokinin; Dose-Response Relationship, Drug; Glutamine; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Pancreas; Proglumide; Sincalide; Tetragastrin | 1984 |
[Ulcer therapy with the gastrin receptor antagonist proglumide. Results of the field study].
Topics: Drug Tolerance; Duodenal Ulcer; Gastrins; Glutamine; Humans; Patient Compliance; Proglumide; Receptors, Cell Surface; Stomach Ulcer | 1981 |
Feeding behavior response of Zucker rats to proglumide, a CCK receptor antagonist.
Topics: Animals; Feeding Behavior; Glutamine; Male; Proglumide; Rats; Rats, Zucker; Receptors, Cell Surface; Receptors, Cholecystokinin | 1983 |
Evidence that proglumide and benzotript antagonize secretagogue stimulation of isolated gastric parietal cells.
Topics: Aminopyrine; Animals; Benzamides; Gastric Juice; Gastrins; Glutamine; In Vitro Techniques; Proglumide; Rabbits; Receptors, Cell Surface; Receptors, Cholecystokinin | 1983 |
Proglumide inhibition of trophic action of pentagastrin.
Topics: Animals; DNA Replication; Drug Antagonism; Gastric Mucosa; Gastrins; Glutamine; Intestinal Mucosa; Kinetics; Male; Pancreas; Pentagastrin; Proglumide; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Cholecystokinin; Sebaceous Glands | 1984 |
The effects of proglumide on morphine induced motility changes.
Topics: Animals; Glutamine; Male; Morphine; Motor Activity; Proglumide; Rats; Rats, Inbred Strains | 1984 |
Proglumide prevents and curtails acute tolerance to morphine in rats.
Topics: Animals; Cholecystokinin; Drug Tolerance; Glutamine; Male; Morphine; Proglumide; Rats; Rats, Inbred Strains | 1984 |
The cholecystokinin antagonist, proglumide, increases food intake in the rat.
Topics: Animals; Appetite; Cholecystokinin; Energy Intake; Fasting; Glutamine; Hunger; Male; Proglumide; Rats; Rats, Inbred Strains | 1984 |
Proglumide antagonizes the stimulation of rabbit gallbladder by cholecystokinin.
Topics: Acetylcholine; Animals; Cholecystokinin; Female; Gallbladder; Glutamine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Proglumide; Rabbits; Serotonin | 1984 |
Potentiation of opiate analgesia and apparent reversal of morphine tolerance by proglumide.
Topics: Analgesia; Animals; Brain; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Endorphins; Enkephalin, Methionine; Glutamine; Humans; Injections, Spinal; Morphine; Proglumide; Rats; Spinal Cord | 1984 |
[Transmural gastric potential difference (PD) and intragastric diurnal pH profile with proglumide].
Topics: Adult; Aspirin; Cimetidine; Circadian Rhythm; Double-Blind Method; Female; Gastric Acidity Determination; Gastric Mucosa; Glutamine; Humans; Male; Membrane Potentials; Proglumide | 1983 |
Proglumide: selective antagonism of the rumination but not gastric motor effects induced by pentagastrin in sheep.
Topics: Abomasum; Animals; Electromyography; Female; Gastroesophageal Reflux; Gastrointestinal Motility; Glutamine; Infusions, Parenteral; Injections, Intravenous; Injections, Intraventricular; Pentagastrin; Proglumide; Sheep; Stomach, Ruminant | 1984 |
Cholecystokinin tetrapeptide, proglumide and open-field behavior in rats.
Topics: Animals; Behavior, Animal; Defecation; Drug Synergism; Gastrins; Glutamine; Male; Motor Activity; Proglumide; Rats; Rats, Inbred Strains; Tetragastrin | 1984 |
Effect of proglumide, a cholecystokinin receptor antagonist, on caerulein-stimulated pancreatic enzyme secretion and pancreatic polypeptide release in the dog.
Topics: Animals; Ceruletide; Cholecystokinin; Depression, Chemical; Dogs; Dose-Response Relationship, Drug; Glutamine; Pancreas; Pancreatic Juice; Pancreatic Polypeptide; Proglumide | 1984 |
Effects of proglumide and metiamide on vagally stimulated gastric acid secretion in chickens.
Topics: Animals; Chickens; Gastric Acid; Glutamine; Male; Metiamide; Proglumide; Thiourea; Vagotomy; Vagus Nerve | 1982 |
Proglumide: selective antagonism of excitatory effects of cholecystokinin in central nervous system.
Topics: Animals; Brain; Cerebral Cortex; Cholecystokinin; Drug Antagonism; Glutamine; Male; Mesencephalon; Neurons; Proglumide; Rats | 1983 |
The effects of proglumide on cholecystokinin-, bombesin-, and glucagon-induced satiety in the rat.
Topics: Animals; Appetite; Bombesin; Cholecystokinin; Dose-Response Relationship, Drug; Food Deprivation; Glucagon; Glutamine; Male; Peptides; Proglumide; Rats; Rats, Inbred Strains; Time Factors | 1983 |
High-performance liquid chromatographic determination of proglumide in plasma.
Topics: Chromatography, High Pressure Liquid; Glutamine; Humans; Male; Proglumide; Time Factors | 1982 |
[Effects of proglumide on gastric motility].
Topics: Adult; Aged; Dyspepsia; Female; Gastric Emptying; Gastric Juice; Gastrointestinal Motility; Glutamine; Humans; Male; Middle Aged; Proglumide | 1981 |
[Effect of acute administration of proglumide on serum gastrin and basal gastric acid secretion in normal subjects and patients with duodenal ulcer].
Topics: Adult; Duodenal Ulcer; Gastric Acid; Gastrins; Glutamine; Humans; Middle Aged; Proglumide | 1981 |
The role of gastric mucosal hexosamine in aspirin-induced ulcers.
Topics: Animals; Aspirin; Gastric Mucosa; Glutamine; Hexosamines; Male; Proglumide; Rats; Stomach Ulcer; Wound Healing | 1980 |
Effect of proglumide on glycoprotein synthesis in aspirin-induced gastric erosions in rats.
Topics: Acetylglucosamine; Animals; Aspirin; Fasting; Gastric Mucosa; Glutamine; Glycoproteins; Male; Proglumide; Rats; Species Specificity; Stomach Ulcer | 1980 |