glutamine has been researched along with methotrexate in 39 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (33.33) | 18.7374 |
| 1990's | 9 (23.08) | 18.2507 |
| 2000's | 6 (15.38) | 29.6817 |
| 2010's | 11 (28.21) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Goh, SH; Léjohn, HB | 1 |
| Kaiser, E; Müller, MM | 1 |
| Barrueco, JR; O'Leary, DF; Sirotnak, FM | 1 |
| Broadwater, JR; Jensen, JC; Klimberg, VS; Lang, NP; Nwokedi, E; Pappas, AA; Westbrook, KC | 1 |
| Bakker, MA; Bökkerink, JP; De Abreu, RR; De Bruyn, CH; Hulscher, TW; Schretlen, ED; van Laarhoven, JP | 1 |
| Cole, DE; Holcenberg, JS; Jolivet, J; Poplack, DG | 1 |
| Henderson, GB; Kumar, HP; Tsuji, JM | 1 |
| van Os, FH | 1 |
| Gerron, GG; Howard, CH; Rudman, D; Vogler, WR | 1 |
| Henderson, ES; Leventhal, BG | 1 |
| Fry, DW; Goldman, ID; Yalowich, JC | 1 |
| Fry, DW; Gewirtz, DA; Goldman, ID; Yalowich, JC | 1 |
| Trombe, MC | 1 |
| Brown, OE; Fyfe, MJ; Laszlo, J; Sedwick, WD | 1 |
| Epstein, J; Klimberg, VS; Nwokedi, E; Rouse, K; Woodliff, JE | 1 |
| Bertino, JR; Gritsman, H; Li, WW; Tong, WP; Waltham, MC | 1 |
| Cao, Y; Hutchins, LF; Klimberg, VS; Rubio, IT; Westbrook, KC | 1 |
| Babiak, RM; Campello, AP; Carnieri, EG; Oliveira, MB | 1 |
| Sugimura, K; Sukemori, S | 1 |
| Cook, AK; Greve, C; Kass, PH; Marks, SL; Reader, R; Rogers, QR; Théon, AP | 1 |
| Abcouwer, SF; Lin, CM; Souba, WW | 1 |
| ANDERSON, EP; BROCKMAN, RW | 1 |
| Albertioni, F; Assaraf, YG; Fotoohi, K; Gregorczyk, J; Jansen, G; Kathmann, I; Peters, GJ; Rothem, L; Stark, M | 1 |
| Harsha, WT; Irwin, R; Kalandarova, E; McNutt, P; Noel, J | 1 |
| Basset, G; Hanson, AD; Nichols, BP; Ravanel, S; Rébeillé, F; Sahr, T | 1 |
| Coran, AG; Karry, R; Kokhanovsky, N; Lurie, M; Mogilner, JG; Shamian, B; Sukhotnik, I; Ure, BM | 1 |
| Kaji, H; Maiguma, T; Makino, K; Teshima, D | 1 |
| Aziz, M; Blum, S; Boukhettala, N; Breuillé, D; Coëffier, M; Déchelotte, P; Ibrahim, A; Saudan, KY; Vuichoud, J | 1 |
| García, JA; Marín Pozo, JF; Muriel, AC; Porras, IC | 1 |
| Erdem, O; Gulgun, M; Karaoglu, A; Kesik, V; Kismet, E; Koseoglu, V; Kurt, B; Ozcan, O; Tok, D | 1 |
| Beutheu, S; Coëffier, M; Déchelotte, P; Galas, L; Ghouzali, I | 1 |
| Aziz, M; Belmonte, L; Beutheu, S; Bôle-Feysot, C; Coëffier, M; Déchelotte, P; Galas, L; Guérin, C; Ouelaa, W; Tennoune, N | 1 |
| Bobrovnikova-Marjon, E; Hurov, JB | 1 |
| Edinger, D; Höhn, M; Kos, P; Lächelt, U; Müller, K; Wagner, E; Wittmann, V | 1 |
| Hyun, S; Kim, S; Lee, Y; Yu, J | 1 |
| Chang, YH; Chao, YH; Chiou, YH; Hsu, MC; Peng, CT; Wu, HP; Wu, KH; Yu, MS | 1 |
4 review(s) available for glutamine and methotrexate
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Plants with cytostatic effect].
Topics: Alkaloids; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Nucleus; Cell Transformation, Neoplastic; Colchicine; Colchicum; DNA; Drug Synergism; Glutamine; Glycolysis; Humans; Leukemia; Mercaptopurine; Methotrexate; Mitosis; Neoplasms; Plant Extracts; Plants, Medicinal; Plants, Toxic; Podophyllum; Prednisone; Purines; Pyrimidines; RNA; Steroids; Vincristine | 1970 |
BIOCHEMISTRY OF CANCER (METABOLIC ASPECTS).
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Azaserine; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; Floxuridine; Fluorouracil; Folic Acid; Glutamine; Leukemia L1210; Mercaptopurine; Methotrexate; Mitomycin; Neoplasms; Neoplasms, Experimental; Pharmacology; Purines; Puromycin; Pyrimidines; Research; RNA; RNA, Neoplasm; Thioguanine; Thiouracil | 1963 |
Targeting metabolic changes in cancer: novel therapeutic approaches.
Topics: Antimetabolites, Antineoplastic; Biomarkers, Tumor; DNA-Binding Proteins; Fatty Acids; Glutamine; Humans; Isocitrate Dehydrogenase; Methotrexate; NAD; Neoplasms; Phosphopyruvate Hydratase; Signal Transduction; Tumor Suppressor Proteins | 2014 |
1 trial(s) available for glutamine and methotrexate
| Article | Year |
|---|---|
Effect of glutamine on methotrexate efficacy and toxicity.
Topics: Adult; Aged; Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Evaluation Studies as Topic; Female; Glutamine; Humans; Mammary Neoplasms, Experimental; Methotrexate; Middle Aged; Random Allocation; Rats; Rats, Inbred F344; Survival Analysis | 1998 |
34 other study(ies) available for glutamine and methotrexate
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Genetical and biochemical evidence that a novel dinucleoside polyphosphate coordinates salvage and de novo nucleotide biosynthetic pathways in mammalian cells.
Topics: Azaserine; Cell Line; Fluorouracil; Genes; Glutamine; Guanosine Triphosphate; Methotrexate; Mutation; Oligonucleotides; Oligoribonucleotides; Ribonucleotides | 1977 |
[Regulation of purine metabolism and its modification by drugs].
Topics: Allopurinol; Antimetabolites; Azathioprine; Benzofurans; Chemical Phenomena; Chemistry; Erythrocytes; Folic Acid Antagonists; Glutamine; Gout; Humans; Metabolic Clearance Rate; Methotrexate; Purines; Time Factors; Transferases; Xanthine Oxidase | 1975 |
Facilitated transport of methotrexate polyglutamates into lysosomes derived from S180 cells. Further characterization and evidence for a simple mobile carrier system with broad specificity for homo- or heteropeptides bearing a C-terminal glutamyl moiety.
Topics: Animals; Binding, Competitive; Biological Transport, Active; Glutamates; Glutamine; Hydrogen-Ion Concentration; Kinetics; Lysosomes; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Polyglutamic Acid; Sarcoma 180; Temperature | 1992 |
Effect of supplemental dietary glutamine on methotrexate concentrations in tumors.
Topics: Animals; Body Weight; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Synergism; Energy Intake; Glutamine; Humans; Male; Methotrexate; Rats; Rats, Inbred F344; Sarcoma, Experimental | 1992 |
Sequence-, time- and dose-dependent synergism of methotrexate and 6-mercaptopurine in malignant human T-lymphoblasts.
Topics: Aminoimidazole Carboxamide; Cell Line; Drug Synergism; Glutamine; Glycine; Humans; Hypoxanthine; Hypoxanthines; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Phosphoribosyl Pyrophosphate; Purines; Ribonucleotides; T-Lymphocytes | 1986 |
Prevention of methotrexate cytotoxicity by asparaginase inhibition of methotrexate polyglutamate formation.
Topics: Animals; Asparaginase; Asparagine; Biological Transport; Cell Survival; DNA Replication; Glutamates; Glutamic Acid; Glutamine; Kinetics; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Peptides; Polyglutamic Acid | 1985 |
Folate transport in Lactobacillus salivarius. Characterization of the transport mechanism and purification and properties of the binding component.
Topics: Biological Transport; Biotin; Carrier Proteins; Cell Membrane; Chromatography; Folate Receptors, GPI-Anchored; Folic Acid; Glucose; Glutamine; Kinetics; Lactobacillus; Methotrexate; Molecular Weight; Receptors, Cell Surface; Thiamine | 1987 |
Observations on the plasma amino acids of patients with acute leukemia.
Topics: Acute Disease; Alanine; Amino Acids; Asparaginase; Cytarabine; Glucocorticoids; Glutamine; Histidine; Humans; Indicators and Reagents; Leukemia; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Methionine; Methotrexate; Nitrogen; Proline; Threonine; Vincristine | 1971 |
Therapy of acute leukemia with drug combinations which include asparaginase.
Topics: Adolescent; Adult; Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Azaserine; Child; Child, Preschool; Cytarabine; Female; Glutamine; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mercaptopurine; Methotrexate; Middle Aged; Prednisolone; Remission, Spontaneous; Vincristine | 1971 |
Rapid formation of poly-gamma-glutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascites tumor cell in vitro.
Topics: Animals; Biological Transport; Carcinoma, Ehrlich Tumor; Chromatography, High Pressure Liquid; Folic Acid; Glutamates; Glutamic Acid; Glutamine; Kinetics; Male; Methotrexate; Mice; Pteroylpolyglutamic Acids; Tetrahydrofolate Dehydrogenase | 1982 |
Characteristics of the accumulation of methotrexate polyglutamate derivatives in Ehrlich ascites tumor cells and isolated rat hepatocytes.
Topics: Animals; Carcinoma, Ehrlich Tumor; Glutamine; In Vitro Techniques; Kinetics; Liver; Male; Methotrexate; Mice; Peptides; Polyglutamic Acid; Rats; Rats, Inbred Strains; Tritium; Vincristine | 1983 |
Alteration of Streptococcus pneumoniae membrane properties by the folate analog methotrexate.
Topics: Biological Transport; Cell Membrane; Glutamine; Isoleucine; Kinetics; Membrane Potentials; Methotrexate; Mutation; Species Specificity; Streptococcus pneumoniae | 1984 |
Human plasma and amino acids as moderators of uptake and metabolic consequences of antifolates in WIL-2 and human leukemia cells.
Topics: Amino Acids; Blood; Cell Line; Culture Media; Deoxyuridine; Folic Acid Antagonists; Glutamine; Humans; Kinetics; Leukemia; Lymphocytes; Methotrexate; Pyrimethamine | 1981 |
Glutamine enhances selectivity of chemotherapy through changes in glutathione metabolism.
Topics: Animals; Drug Synergism; Glutamine; Glutathione; Methotrexate; Rats; Rats, Inbred F344; Sarcoma, Experimental | 1995 |
gamma-Glutamyl hydrolase from human sarcoma HT-1080 cells: characterization and inhibition by glutamine antagonists.
Topics: Azaserine; Diazooxonorleucine; Enzyme Inhibitors; gamma-Glutamyl Hydrolase; Glutamine; Humans; Isoxazoles; Kinetics; Methotrexate; Sarcoma; Substrate Specificity; Tumor Cells, Cultured | 1997 |
Methotrexate: pentose cycle and oxidative stress.
Topics: Aminoacyltransferases; Antioxidants; Enzyme Inhibitors; Folic Acid Antagonists; Glucosephosphate Dehydrogenase; Glutamine; Glutathione; Glutathione Reductase; HeLa Cells; Humans; Leucovorin; Methotrexate; Oxidation-Reduction; Oxidative Stress; Pentose Phosphate Pathway; Peroxidases; Phosphogluconate Dehydrogenase; Reactive Oxygen Species; Superoxide Dismutase; Transketolase | 1998 |
Extracellular glutamine level reduction enhances 5-fluorouracil cytotoxicity.
Topics: Amino Acids; Animals; Asparagine; Cell Count; Dose-Response Relationship, Drug; Fluorouracil; Glutamine; Humans; Leukemia; Leukemia P388; Methotrexate; Mice; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured | 1998 |
Effects of glutamine supplementation of an amino acid-based purified diet on intestinal mucosal integrity in cats with methotrexate-induced enteritis.
Topics: Amino Acids; Analysis of Variance; Animal Feed; Animals; Cats; Cell Division; Dietary Supplements; Duodenum; Enteritis; Glutamine; Intestinal Mucosa; Lymph Nodes; Male; Methotrexate | 1999 |
Effect of dietary glutamate on chemotherapy-induced immunosuppression.
Topics: Animals; Antineoplastic Agents; Diet; Female; Glutamic Acid; Glutamine; Glutathione; Hypersensitivity, Delayed; Immunologic Deficiency Syndromes; Lymphocyte Activation; Methotrexate; Rats; Rats, Inbred F344 | 1999 |
Disparate mechanisms of antifolate resistance provoked by methotrexate and its metabolite 7-hydroxymethotrexate in leukemia cells: implications for efficacy of methotrexate therapy.
Topics: Antimetabolites, Antineoplastic; Biological Transport; Cell Line, Tumor; Drug Resistance, Neoplasm; Glutamine; Humans; Leukemia; Methotrexate | 2004 |
Nutritional supplementation with transforming growth factor-beta, glutamine, and short chain fatty acids minimizes methotrexate-induced injury.
Topics: Animals; Antimetabolites, Antineoplastic; Body Weight; Diet; Dietary Supplements; Fatty Acids, Volatile; Glutamine; Intestinal Mucosa; Intestine, Small; Methotrexate; Mucositis; Random Allocation; Rats; Rats, Inbred F344; Transforming Growth Factor beta | 2006 |
Folate synthesis in plants: purification, kinetic properties, and inhibition of aminodeoxychorismate synthase.
Topics: 4-Aminobenzoic Acid; Arabidopsis Proteins; Carbon-Nitrogen Ligases; Chorismic Acid; Escherichia coli; Folic Acid; Glutamine; Kinetics; Methotrexate; Pyruvic Acid; Recombinant Fusion Proteins; Substrate Specificity; Transaminases | 2006 |
Effect of oral glutamine on enterocyte turnover during methotrexate-induced mucositis in rats.
Topics: Administration, Oral; Analysis of Variance; Animals; Apoptosis; bcl-2-Associated X Protein; Enterocytes; Glutamine; Intestinal Mucosa; Male; Methotrexate; Mucositis; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction | 2009 |
Protective effects of amifostine and cyclooxygenase-1 inhibitor against normal human epidermal keratinocyte toxicity induced by methotrexate and 5-fluorouracil.
Topics: Allopurinol; Amifostine; Antimetabolites, Antineoplastic; Calcium; Cell Line; Cell Proliferation; Cell Survival; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Interactions; Fibroblasts; Fluorouracil; Free Radical Scavengers; Glutamine; Humans; Keratinocytes; Methotrexate; Periodontal Ligament; Protective Agents; Pyrazoles; Reactive Oxygen Species; Stomatitis | 2009 |
A diet containing whey protein, free glutamine, and transforming growth factor-beta ameliorates nutritional outcome and intestinal mucositis during repeated chemotherapeutic challenges in rats.
Topics: alpha-Macroglobulins; Animals; Antineoplastic Agents; Body Composition; Body Weight; Diet; Eating; Glutamine; Immunoglobulin A, Secretory; Jejunum; Male; Methotrexate; Milk Proteins; Mucositis; Orosomucoid; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta; Whey Proteins | 2010 |
Hazards of concomitant administration of methotrexate and glutamine.
Topics: Antimetabolites, Antineoplastic; Drug Interactions; Glutamine; Humans; Hydrogen-Ion Concentration; Methotrexate | 2010 |
Effect of proanthocyanidin, arginine and glutamine supplementation on methotrexate-induced gastrointestinal toxicity in rats.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antioxidants; Arginine; Drug Therapy, Combination; Glutamine; Glutathione Peroxidase; Injections, Intraperitoneal; Intestinal Diseases; Male; Malondialdehyde; Methotrexate; Proanthocyanidins; Rats; Rats, Wistar; Severity of Illness Index; Superoxide Dismutase | 2010 |
Glutamine and arginine improve permeability and tight junction protein expression in methotrexate-treated Caco-2 cells.
Topics: Antimetabolites, Antineoplastic; Arginine; Caco-2 Cells; Dietary Supplements; Enterocytes; Folic Acid Antagonists; Gastrointestinal Agents; Glutamine; Humans; Intestinal Mucosa; Methotrexate; Mucositis; Nucleic Acid Synthesis Inhibitors; Occludin; Permeability; Protein Transport; Signal Transduction; Tight Junctions; Up-Regulation; Zonula Occludens-1 Protein | 2013 |
Glutamine supplementation, but not combined glutamine and arginine supplementation, improves gut barrier function during chemotherapy-induced intestinal mucositis in rats.
Topics: Animals; Arginine; Dietary Supplements; Disease Models, Animal; Gastrointestinal Tract; Glutamine; Immunohistochemistry; Intestines; Male; Methotrexate; Mucositis; NF-kappa B; Occludin; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2014 |
Synthetic polyglutamylation of dual-functional MTX ligands for enhanced combined cytotoxicity of poly(I:C) nanoplexes.
Topics: Antineoplastic Agents; Cell Line; Cell Line, Tumor; Drug Delivery Systems; Drug Design; Female; Folic Acid Antagonists; Glutamine; Humans; Ligands; Methotrexate; Microscopy, Fluorescence; Peptides; Poly I-C; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Transfection; Uterine Cervical Neoplasms | 2014 |
Nonhemolytic Cell-Penetrating Peptides: Site Specific Introduction of Glutamine and Lysine Residues into the α-Helical Peptide Causes Deletion of Its Direct Membrane Disrupting Ability but Retention of Its Cell Penetrating Ability.
Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Cations; Cell Membrane; Cell Survival; Cell-Penetrating Peptides; Drug Delivery Systems; Female; Glutamine; Hemolysis; Humans; Hydrophobic and Hydrophilic Interactions; Lysine; Methotrexate; Mutation; Structure-Activity Relationship; Tumor Cells, Cultured | 2016 |
Effectiveness of Parenteral Glutamine on Methotrexate-induced Oral Mucositis in Children with Acute Lymphoblastic Leukemia.
Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Female; Glutamine; Humans; Male; Methotrexate; Parenteral Nutrition; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retrospective Studies; Stomatitis | 2017 |