glutamine and guanosine triphosphate

glutamine has been researched along with guanosine triphosphate in 73 studies

Research

Studies (73)

TimeframeStudies, this research(%)All Research%
pre-199016 (21.92)18.7374
1990's20 (27.40)18.2507
2000's21 (28.77)29.6817
2010's13 (17.81)24.3611
2020's3 (4.11)2.80

Authors

AuthorsStudies
Henderson, JF; Smith, CM; Zombor, G1
Kane, JF; O'Brien, HD1
Goh, SH; Léjohn, HB1
Guder, WG; Schmidt, U1
Canioni, P; Labouesse, J; Merle, M; Pianet, I1
Langen, R; Schweins, T; Warshel, A1
Bourne, HR; Masters, SB; Zachary, I1
Lewis, DA; Villafranca, JJ1
Barrett, D; Breslau, NA; Downs, RW; Molinoff, PB; Wax, MB1
Bergamini, CM; Signorini, M1
Henshaw, EC; Panniers, R; Rowlands, AG; Scorsone, KA1
Buniatian, GKh1
Koshland, DE; Levitzki, A1
Atherly, AG; Barrett, A; Kaplan, S1
Koshland, DE; Levitzki, A; Stallcup, WB1
Smythies, JR1
Knowlton, RG; Yarus, M1
Eady, RR; Nair, MB1
Goldstein, L; Tullson, P1
Hilgenfeld, R1
Geyer, M; Kalbitzer, HR; Scheffzek, K; Schweins, T; Warshel, A; Wittinghofer, A1
Bocchini, V; Krab, IM; Parmeggiani, A; Scarano, G1
Erecińska, M; Nelson, D1
Berghuis, AM; Coleman, DE; Gilman, AG; Lee, E; Linder, ME; Sprang, SR1
Adeline, MT; Carman, GM; Flocco, MT; McDonough, VM; Ozier-Kalogeropoulos, O; Yang, WL1
Anderson, MW; Charifson, PS; Darden, TA; Foley, CK; Frech, M; Pedersen, LG; Wittinghofer, A1
Cullen, G; Dolphin, AC; Fazeli, MS; Huston, E; Pearson, H; Sweeney, MI1
Johnson, GL; Russell, M1
Allison, WS; Di Pietro, A; Divita, G; Jault, JM1
Birckbichler, PJ; Itoh, Y; Ohashi, H; Takeuchi, Y1
Schweins, T; Warshel, A1
Aktories, K; Mann, M; Schmidt, G; Sehr, P; Selzer, J; Wilm, M1
Boquet, P; Chardin, P; Fiorentini, C; Flatau, G; Gauthier, M; Lemichez, E; Paris, S1
Horiguchi, Y; Inoue, N; Kashimoto, T; Katahira, J; Masuda, M; Matsuda, M; Sugimoto, N1
Andorn, R; Chorev, M; Selinger, Z; Sofer, I; Zor, T1
Coleman, DE; Sprang, SR1
Bienengraeber, M; Echtay, KS; Klingenberg, M; Winkler, E1
Dixon, DA; Miller, JH; Resat, H; Straatsma, TP1
Anno, T; Furukawa, S; Inoue, H; Koga, M; Matsuo, K; Nakai, K; Ohta, Y; Oka, Y; Sasaki, T; Tanizawa, Y1
Brieba, LG; Padilla, R; Sousa, R1
Sigurskjold, BW; Willemoës, M1
Bearne, SL; Iyengar, A2
Bearne, SL; Hewitt, KA; Iyengar, A; Lunn, F; Simard, D1
Navratil, T; Spremulli, LL1
Willemoës, M1
Bearne, SL; Lunn, FA; MacDonnell, JE2
Hunter, SE; Spremulli, LL1
Buckingham, RH; Champ, S; Heurgué-Hamard, V; Kisselev, LL; Merkoulova-Rainon, T; Merkulova-Rainon, T; Mora, L1
Aptekar, L; Berenshtein, E; Goldin, E; Israeli, E; Kohen, R; Wengrower, D; Zajicek, G1
Gara, SK; Mishra, R; Mishra, S; Prakash, B1
Castro, LI; Hermsen, C; Linder, JU; Schultz, JE1
Cerione, RA; Majumdar, S; Ramachandran, S1
Brownie, ER; Fraser, ME; Hayakawa, K; Hume, MS; Ryan, DG1
Collins, HW; Daikhin, Y; Hsu, BY; Kelly, A; Kwagh, J; Lazarow, A; Li, C; MacMullen, C; Matschinsky, FM; Matter, A; Najafi, H; Nissim, I; Petty, TJ; Stanley, CA; Yudkoff, M1
Deaconescu, D; Scrima, A; Thomas, C; Wittinghofer, A1
Deng, S; Derbyshire, ER; Marletta, MA1
Hot, E; Keilberg, D; Koerner, C; Leonardy, S; Miertzschke, M; Søgaard-Andersen, L; Vetter, IR; Wittinghofer, A1
Durán, RV; Gottlieb, E; Hall, MN; Heiserich, L; Oppliger, W; Robitaille, AM; Skendaj, R1
Gavriljuk, K; Gazdag, EM; Gerwert, K; Goody, RS; Itzen, A; Kötting, C1
Anand, B; Majumdar, S; Prakash, B1
Calise, SJ; Carcamo, WC; Chan, EK; Krueger, C; Purich, DL; Yin, JD1
Grigorenko, BL; Khrenova, MG; Mironov, VA; Nemukhin, AV1
Jang, H; Lu, S; Nussinov, R; Zhang, J1
Cheng, Z; Lin, M; Liu, H; Niu, H; Rikihisa, Y; Xiong, Q; Yamamoto, A1
Acharya, A; Majumdar, S; Prakash, B1
Brut, M; Cabantous, S; Favre, G; Hemeryck, A; Landa, G; Tichauer, RH1
First, JT; Novelli, ET; Webb, LJ1
Chandra, M; Datta, S; Kotyada, C; Narooka, AR; Tripathi, A; Verma, A1
Bearne, SL; Guo, CJ; Liu, JL1
Arang, N; Campbell, SL; DiBerto, JF; Dohlman, HG; Ghosh, S; Gutkind, JS; Hewitt, N; Knight, KM; Ma, N; Martin, SA; Olsen, RHJ; Prakash, A; Roth, BL; Vaidehi, N1
Chen, H; Ding, YQ; Gao, JW; Han, Y; Hu, SS; Tan, TY; Wang, L; Wang, S; Wang, YQ; Yang, MH; Zhao, L1

Reviews

2 review(s) available for glutamine and guanosine triphosphate

ArticleYear
[Mechanisms of ammonia formation in the brain].
    Voprosy biokhimii mozga, 1973, Volume: 8

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Amino Acid Oxidoreductases; Amino Acids; Ammonia; Animals; Aspartic Acid; Brain; Brain Chemistry; Deamination; Dogs; Flavin-Adenine Dinucleotide; Fumarates; Glutamate Dehydrogenase; Glutaminase; Glutamine; Guanosine Triphosphate; Inosine Nucleotides; Mitochondria; Monoamine Oxidase; NAD; NADP; Nerve Tissue Proteins; Niacinamide; Oxidation-Reduction; Oxygen Consumption; Rats

1973
GTP-Dependent Regulation of CTP Synthase: Evolving Insights into Allosteric Activation and NH
    Biomolecules, 2022, 04-29, Volume: 12, Issue:5

    Topics: Adenosine Triphosphate; Allosteric Regulation; Carbon-Nitrogen Ligases; Cryoelectron Microscopy; Cytidine Triphosphate; Glutaminase; Glutamine; Guanosine Triphosphate; Nitric Oxide Synthase; Uridine Triphosphate

2022

Other Studies

71 other study(ies) available for glutamine and guanosine triphosphate

ArticleYear
Inhibitors of hypoxanthine metabolism in Ehrlich ascites tumor cells in vitro.
    Cancer treatment reports, 1976, Volume: 60, Issue:10

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Carcinoma, Ehrlich Tumor; Cyclic GMP; Energy Metabolism; Glutamine; Guanine Nucleotides; Guanosine Triphosphate; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; In Vitro Techniques; Inosine Nucleotides; Ketone Oxidoreductases; Ligases; Lyases; Mice; Purines

1976
p-Aminobenzoate-p-aminobenzoate.
    Journal of bacteriology, 1975, Volume: 123, Issue:3

    Topics: Aminobenzoates; Ammonia; Bacillus subtilis; Chorismic Acid; Dose-Response Relationship, Drug; Edetic Acid; Glutamine; Guanosine; Guanosine Triphosphate; Hydrogen-Ion Concentration; Magnesium; Molecular Weight; Transaminases

1975
Genetical and biochemical evidence that a novel dinucleoside polyphosphate coordinates salvage and de novo nucleotide biosynthetic pathways in mammalian cells.
    Biochemical and biophysical research communications, 1977, Jan-10, Volume: 74, Issue:1

    Topics: Azaserine; Cell Line; Fluorouracil; Genes; Glutamine; Guanosine Triphosphate; Methotrexate; Mutation; Oligonucleotides; Oligoribonucleotides; Ribonucleotides

1977
Substrate and oxygen dependence of renal metabolism.
    Kidney international. Supplement, 1976, Volume: 6

    Topics: Adenosine Triphosphate; Animals; Blood Glucose; Citric Acid Cycle; Dogs; Energy Metabolism; Energy Transfer; Glutamine; Glycolysis; Guanosine Triphosphate; Humans; Kidney; Mitochondria; Nephrons; Oxidation-Reduction; Oxygen Consumption; Palmitates; Pyruvate Dehydrogenase Complex; Pyruvates; Rabbits; Rats

1976
Beta-adrenergic stimulation of C6 glioma cells: effects of cAMP overproduction on cellular metabolites. A multinuclear NMR study.
    European journal of biochemistry, 1992, Oct-15, Volume: 209, Issue:2

    Topics: Adenosine Triphosphate; Animals; Carbon Isotopes; Cyclic AMP; Glioma; Glucose; Glutamates; Glutamine; Guanosine Triphosphate; Isoproterenol; Kinetics; Lactates; Magnetic Resonance Spectroscopy; Phosphorus; Phosphorylation; Receptors, Adrenergic, beta; Tumor Cells, Cultured

1992
On the mechanism of guanosine triphosphate hydrolysis in ras p21 proteins.
    Biochemistry, 1992, Sep-22, Volume: 31, Issue:37

    Topics: Glutamine; GTP-Binding Proteins; Guanosine Triphosphate; Hydrolysis; Models, Molecular; Proto-Oncogene Proteins p21(ras); Structure-Activity Relationship; Thermodynamics; Water

1992
Increased mitogenic responsiveness of Swiss 3T3 cells expressing constitutively active Gs alpha.
    Biochemical and biophysical research communications, 1990, May-16, Volume: 168, Issue:3

    Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Cell Line; Cell Membrane; Cell Transformation, Neoplastic; Cyclic AMP; Enzyme Activation; Glutamine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hydrolysis; Immunoblotting; Leucine; Mitogens; Molecular Sequence Data; Mutation; Thionucleotides; Transfection

1990
Investigation of the mechanism of CTP synthetase using rapid quench and isotope partitioning methods.
    Biochemistry, 1989, Oct-17, Volume: 28, Issue:21

    Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Carbon-Nitrogen Ligases; Chemical Phenomena; Chemistry; Cytidine Triphosphate; Cytosine Nucleotides; Escherichia coli; Glutamine; Guanosine Triphosphate; Kinetics; Ligases; Phosphorus Radioisotopes; Phosphorylation; Uridine Triphosphate

1989
New form of pseudohypoparathyroidism with abnormal catalytic adenylate cyclase.
    The American journal of physiology, 1989, Volume: 257, Issue:2 Pt 1

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Adult; Cell Line; Cell Membrane; Cyclic AMP; Fibroblasts; Glutamine; Guanosine Triphosphate; Humans; Isoproterenol; Pseudohypoparathyroidism; Reference Values; Skin

1989
Calcium dependent reversible inactivation of erythrocyte transglutaminase by acrylamide.
    Biochemistry international, 1988, Volume: 17, Issue:5

    Topics: Acrylamides; Calcium; Enzyme Activation; Enzyme Reactivators; Erythrocytes; Glutamine; Guanosine Triphosphate; Humans; Sulfhydryl Compounds; Time Factors; Transglutaminases

1988
Phosphorylation of eukaryotic initiation factor 2 during physiological stresses which affect protein synthesis.
    The Journal of biological chemistry, 1987, Oct-25, Volume: 262, Issue:30

    Topics: Cells, Cultured; Emetine; Eukaryotic Initiation Factor-2; Glucose; Glutamine; Guanine Nucleotide Exchange Factors; Guanosine Diphosphate; Guanosine Triphosphate; Hot Temperature; Peptide Initiation Factors; Phosphorylation; Protein Biosynthesis; Proteins

1987
Role of an allosteric effector. Guanosine triphosphate activation in cytosine triphosphate synthetase.
    Biochemistry, 1972, Jan-18, Volume: 11, Issue:2

    Topics: Adenosine Triphosphate; Allosteric Regulation; Ammonia; Binding Sites; Carbon Isotopes; Cytosine Nucleotides; Dialysis; Enzyme Activation; Escherichia coli; Filtration; Glutaminase; Glutamine; Guanosine Triphosphate; Kinetics; Ligases; Macromolecular Substances; Mathematics; Models, Chemical; Protein Binding; Protein Conformation; Temperature; Tritium; Uracil Nucleotides

1972
Synthesis of stable RNA in stringent Escherichia coli cells in the absence of charged transfer RNA.
    Proceedings of the National Academy of Sciences of the United States of America, 1973, Volume: 70, Issue:3

    Topics: Amino Acyl-tRNA Synthetases; Bacterial Proteins; Chloramphenicol; Escherichia coli; Fusidic Acid; Glutamine; Guanine Nucleotides; Guanosine Triphosphate; Mutation; RNA, Bacterial; RNA, Transfer; Temperature; Tetracycline; Tritium; Uracil; Valine

1973
Half-of-the-sites reactivity and the conformational states of cytidine triphosphate synthetase.
    Biochemistry, 1971, Aug-31, Volume: 10, Issue:18

    Topics: Adenosine Triphosphate; Ammonia; Benzoates; Binding Sites; Carbon Isotopes; Chemical Phenomena; Chemistry; Cytosine Nucleotides; Diazooxonorleucine; Electrophoresis; Escherichia coli; Glutamine; Guanosine Triphosphate; Kinetics; Ligases; Macromolecular Substances; Magnesium; Models, Biological; Models, Structural; Molecular Weight; Nitro Compounds; Protein Binding; Protein Conformation; Uracil Nucleotides; Urea

1971
Molecular mechanisms of adrenergic receptors.
    Journal of theoretical biology, 1972, Volume: 35, Issue:1

    Topics: Adenine; Adenosine Triphosphate; Adenylyl Cyclases; Benzene; Binding Sites; Catecholamines; Ergolines; Ergotamine; Glutamine; Guanosine Triphosphate; Macromolecular Substances; Models, Structural; Phentolamine; Phenylephrine; Prostaglandins; Receptors, Adrenergic; Receptors, Drug

1972
Discrimination between aminoacyl groups on su+ 7 tRNA by elongation factor Tu.
    Journal of molecular biology, 1980, Jun-05, Volume: 139, Issue:4

    Topics: Escherichia coli; Glutamine; Guanosine Triphosphate; Hydrogen-Ion Concentration; Kinetics; Peptide Elongation Factors; RNA, Bacterial; RNA, Transfer; RNA, Transfer, Amino Acyl; Suppression, Genetic; Tryptophan

1980
Nitrogenase synthesis in Klebsiella pneumoniae: enhanced nif expression without accumulation of guanosine 5'-diphosphate 3'-diphosphate.
    Journal of general microbiology, 1984, Volume: 130, Issue:12

    Topics: Adenosine Triphosphate; Gene Expression Regulation; Genes, Bacterial; Glutamine; Guanine Nucleotides; Guanosine Tetraphosphate; Guanosine Triphosphate; Klebsiella pneumoniae; Nitrogen Fixation; Nitrogenase; Transcription, Genetic

1984
Allosteric regulation of renal alpha-ketoglutarate dehydrogenase.
    Contributions to nephrology, 1982, Volume: 31

    Topics: Acidosis; Adenosine Diphosphate; Adenosine Triphosphate; Allosteric Regulation; Animals; Glutamine; Guanosine Triphosphate; Ketoglutarate Dehydrogenase Complex; Ketoglutaric Acids; Ketone Oxidoreductases; Kidney; Male; Oxidation-Reduction; Rats; Rats, Inbred Strains

1982
How do the GTPases really work?
    Nature structural biology, 1995, Volume: 2, Issue:1

    Topics: Bacterial Proteins; Catalysis; Crystallography, X-Ray; Glutamine; GTP Phosphohydrolase-Linked Elongation Factors; Guanosine Triphosphate; Histidine; Hydrolysis; Models, Chemical; Peptide Elongation Factor Tu; Protein Conformation; Proto-Oncogene Proteins p21(ras); Protons; Structure-Activity Relationship; Thermus thermophilus; Water

1995
Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins.
    Nature structural biology, 1995, Volume: 2, Issue:1

    Topics: Amino Acid Sequence; Animals; Binding Sites; Catalysis; Cell Transformation, Neoplastic; Computer Simulation; Crystallography, X-Ray; Glutamine; GTP-Binding Proteins; GTPase-Activating Proteins; Guanosine Triphosphate; Hydrolysis; Insecta; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Proteins; Proto-Oncogene Proteins p21(ras); ras GTPase-Activating Proteins; Recombinant Fusion Proteins; Structure-Activity Relationship; Thermodynamics; Water

1995
Relevance of histidine-84 in the elongation factor Tu GTPase activity and in poly(Phe) synthesis: its substitution by glutamine and alanine.
    FEBS letters, 1995, May-29, Volume: 365, Issue:2-3

    Topics: Alanine; Amino Acid Sequence; Cloning, Molecular; Escherichia coli; Glutamine; GTP Phosphohydrolase-Linked Elongation Factors; Guanosine Diphosphate; Guanosine Triphosphate; Histidine; Kinetics; Mutagenesis, Site-Directed; Peptide Biosynthesis; Peptide Elongation Factor Tu; Peptides; Point Mutation; Recombinant Proteins

1995
Effects of 3-nitropropionic acid on synaptosomal energy and transmitter metabolism: relevance to neurodegenerative brain diseases.
    Journal of neurochemistry, 1994, Volume: 63, Issue:3

    Topics: Adenosine Triphosphate; Animals; Brain Diseases; Cell Death; Creatine; Energy Metabolism; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Guanosine Diphosphate; Guanosine Triphosphate; Lactates; Lactic Acid; Male; Neurotransmitter Agents; Nitro Compounds; Oxygen Consumption; Phosphocreatine; Propionates; Pyruvates; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Synaptosomes

1994
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis.
    Science (New York, N.Y.), 1994, Sep-02, Volume: 265, Issue:5177

    Topics: Aluminum Compounds; Arginine; Binding Sites; Catalysis; Computer Graphics; Crystallography, X-Ray; Fluorides; Glutamine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Helix-Loop-Helix Motifs; Hydrogen Bonding; Hydrolysis; Models, Molecular; Protein Conformation; Protein Structure, Secondary

1994
Purification and characterization of CTP synthetase, the product of the URA7 gene in Saccharomyces cerevisiae.
    Biochemistry, 1994, Sep-06, Volume: 33, Issue:35

    Topics: Base Sequence; Blotting, Western; Carbon-Nitrogen Ligases; Cloning, Molecular; Cytidine Triphosphate; Glutamine; Guanosine Triphosphate; Hydrogen-Ion Concentration; Kinetics; Ligases; Magnesium; Molecular Sequence Data; Precipitin Tests; Recombinant Proteins; Saccharomyces cerevisiae; Uridine Triphosphate

1994
Role of glutamine-61 in the hydrolysis of GTP by p21H-ras: an experimental and theoretical study.
    Biochemistry, 1994, Mar-22, Volume: 33, Issue:11

    Topics: Binding Sites; Binding, Competitive; Escherichia coli; Glutamine; GTP Phosphohydrolases; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Hydrogen Bonding; Hydrolysis; Mutagenesis, Site-Directed; Proto-Oncogene Proteins p21(ras); Structure-Activity Relationship

1994
Pertussis toxin treatment increases glutamate release and dihydropyridine binding sites in cultured rat cerebellar granule neurons.
    Neuroscience, 1993, Volume: 52, Issue:4

    Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Animals; Baclofen; Barium; Binding Sites; Calcium; Calcium Channels; Cells, Cultured; Cerebellum; Cyclic AMP; Dihydropyridines; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamine; GTP-Binding Proteins; Guanosine Triphosphate; Kinetics; Membrane Potentials; NAD; Neurons; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Virulence Factors, Bordetella

1993
G protein amino-terminal alpha i2/alpha s chimeras reveal amino acids important in regulating alpha s activity.
    Molecular pharmacology, 1993, Volume: 44, Issue:2

    Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cyclic AMP; Enzyme Activation; Glutamine; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Triphosphate; Lysine; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Recombinant Fusion Proteins; Sequence Alignment

1993
Glutamine 170 to tyrosine substitution in yeast mitochondrial F1 beta-subunit increases catalytic site interaction with GDP and IDP and produces negative cooperativity of GTP and ITP hydrolysis.
    The Journal of biological chemistry, 1993, Oct-05, Volume: 268, Issue:28

    Topics: Azides; Bicarbonates; Catalysis; Enzyme Activation; Glutamine; GTP Phosphohydrolases; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Hydrogen-Ion Concentration; Hydrolysis; Inosine Diphosphate; Inosine Nucleotides; Inosine Triphosphatase; Inosine Triphosphate; Mitochondria; Proton-Translocating ATPases; Pyrophosphatases; Schizosaccharomyces; Tyrosine

1993
Purification and characterization of rat brain transglutaminase.
    Journal of biochemistry, 1995, Volume: 118, Issue:6

    Topics: Affinity Labels; Animals; Binding Sites; Blotting, Western; Brain; Cations; Chromatography, Affinity; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Erythrocytes; Glutamine; Guanosine Triphosphate; Guinea Pigs; Humans; Kinetics; Liver; Lysine; Male; Molecular Weight; Rats; Rats, Sprague-Dawley; Transglutaminases

1995
Mechanistic analysis of the observed linear free energy relationships in p21ras and related systems.
    Biochemistry, 1996, Nov-12, Volume: 35, Issue:45

    Topics: Catalysis; Deuterium; Glutamine; GTP Phosphohydrolases; GTP-Binding Proteins; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Mutagenesis, Site-Directed; Proteins; Proto-Oncogene Proteins p21(ras); Protons; ras GTPase-Activating Proteins; Solvents; Structure-Activity Relationship; Thermodynamics

1996
Gln 63 of Rho is deamidated by Escherichia coli cytotoxic necrotizing factor-1.
    Nature, 1997, Jun-12, Volume: 387, Issue:6634

    Topics: 3T3 Cells; Actins; Adenosine Diphosphate Ribose; Amino Acid Sequence; Animals; Bacterial Toxins; Cytoskeleton; Cytotoxins; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Escherichia coli Proteins; Glutamine; Glycosylation; GTP Phosphohydrolases; GTP-Binding Proteins; GTPase-Activating Proteins; Guanosine Triphosphate; Mass Spectrometry; Mice; Microinjections; Molecular Sequence Data; Molecular Weight; ortho-Aminobenzoates; Recombinant Fusion Proteins; rhoA GTP-Binding Protein

1997
Toxin-induced activation of the G protein p21 Rho by deamidation of glutamine.
    Nature, 1997, Jun-12, Volume: 387, Issue:6634

    Topics: Actins; Amino Acid Sequence; Animals; Bacterial Toxins; Chlorocebus aethiops; Cytoskeleton; Cytotoxins; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Escherichia coli Proteins; Glutamine; GTP Phosphohydrolases; GTP-Binding Proteins; GTPase-Activating Proteins; Guanosine Triphosphate; Kinetics; Molecular Sequence Data; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; Vero Cells

1997
Bordetella bronchiseptica dermonecrotizing toxin induces reorganization of actin stress fibers through deamidation of Gln-63 of the GTP-binding protein Rho.
    Proceedings of the National Academy of Sciences of the United States of America, 1997, Oct-14, Volume: 94, Issue:21

    Topics: Actins; Amino Acid Sequence; Amino Acid Substitution; Animals; Bacterial Toxins; Bordetella bronchiseptica; Cell Line; Glutamic Acid; Glutamine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Kinetics; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Recombinant Proteins; rhoA GTP-Binding Protein; Sequence Alignment; Transfection; Transglutaminases; Virulence Factors, Bordetella

1997
GTP analogue hydrolysis by the Gs protein: implication for the role of catalytic glutamine in the GTPase reaction.
    FEBS letters, 1998, Aug-21, Volume: 433, Issue:3

    Topics: Adenosine Triphosphate; Adenylyl Cyclases; Animals; Cell Membrane; Glutamine; GTP Phosphohydrolases; GTP-Binding Protein alpha Subunits, Gs; Guanosine Triphosphate; Hydrolysis; Kinetics; Parotid Gland; Rats; Substrate Specificity

1998
Structure of Gialpha1.GppNHp, autoinhibition in a galpha protein-substrate complex.
    The Journal of biological chemistry, 1999, Jun-11, Volume: 274, Issue:24

    Topics: Animals; Catalytic Domain; Computer Simulation; Crystallography, X-Ray; Glutamine; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Rats; Recombinant Proteins

1999
Site-directed mutagenesis identifies residues in uncoupling protein (UCP1) involved in three different functions.
    Biochemistry, 2000, Mar-28, Volume: 39, Issue:12

    Topics: Adipose Tissue, Brown; Amino Acid Substitution; Animals; Asparagine; Aspartic Acid; Binding Sites; Carrier Proteins; Chlorides; Cricetinae; Electron Transport; Glutamic Acid; Glutamine; Guanosine Triphosphate; Ion Channels; Membrane Proteins; Mitochondria; Mitochondrial Proteins; Mutagenesis, Site-Directed; Protons; Saccharomyces cerevisiae; Uncoupling Agents; Uncoupling Protein 1

2000
The arginine finger of RasGAP helps Gln-61 align the nucleophilic water in GAP-stimulated hydrolysis of GTP.
    Proceedings of the National Academy of Sciences of the United States of America, 2001, May-22, Volume: 98, Issue:11

    Topics: Arginine; Binding Sites; Cluster Analysis; Glutamine; Guanosine Triphosphate; Hydrolysis; p120 GTPase Activating Protein; Proto-Oncogene Proteins p21(ras); Water

2001
Unregulated elevation of glutamate dehydrogenase activity induces glutamine-stimulated insulin secretion: identification and characterization of a GLUD1 gene mutation and insulin secretion studies with MIN6 cells overexpressing the mutant glutamate dehydr
    Diabetes, 2002, Volume: 51, Issue:3

    Topics: Adenosine Diphosphate; Animals; Blood Glucose; COS Cells; DNA Mutational Analysis; Female; Glucose; Glutamate Dehydrogenase; Glutamine; Guanosine Triphosphate; Humans; Hyperinsulinism; Hypoglycemia; Infant; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Mutation; Pancreatic Neoplasms; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Transfection; Tumor Cells, Cultured

2002
Role of T7 RNA polymerase His784 in start site selection and initial transcription.
    Biochemistry, 2002, Apr-23, Volume: 41, Issue:16

    Topics: Alanine; Bacteriophage T7; Base Sequence; Binding Sites; DNA-Directed RNA Polymerases; Glutamine; Guanosine; Guanosine Triphosphate; Histidine; Hydrogen Bonding; Mutagenesis, Site-Directed; Promoter Regions, Genetic; Stereoisomerism; Transcription Initiation Site; Viral Proteins

2002
Steady-state kinetics of the glutaminase reaction of CTP synthase from Lactococcus lactis. The role of the allosteric activator GTP incoupling between glutamine hydrolysis and CTP synthesis.
    European journal of biochemistry, 2002, Volume: 269, Issue:19

    Topics: Allosteric Regulation; Calorimetry; Carbon-Nitrogen Ligases; Cytidine Triphosphate; Glutaminase; Glutamine; Guanosine Triphosphate; Hydrolysis; Kinetics; Lactococcus lactis; Models, Biological

2002
Aspartate-107 and leucine-109 facilitate efficient coupling of glutamine hydrolysis to CTP synthesis by Escherichia coli CTP synthase.
    The Biochemical journal, 2003, Feb-01, Volume: 369, Issue:Pt 3

    Topics: Alanine; Amino Acid Sequence; Aspartic Acid; Carbon-Nitrogen Ligases; Circular Dichroism; Conserved Sequence; Cytidine Triphosphate; Dimerization; Escherichia coli Proteins; Glutamine; Guanosine Triphosphate; Hydrolysis; Leucine; Molecular Sequence Data; Mutagenesis, Site-Directed

2003
An assay for cytidine 5(')-triphosphate synthetase glutaminase activity using high performance liquid chromatography.
    Analytical biochemistry, 2002, Sep-15, Volume: 308, Issue:2

    Topics: Adenosine Triphosphate; Carbon-Nitrogen Ligases; Chromatography, High Pressure Liquid; Colorimetry; Cytidine Triphosphate; Glutaminase; Glutamine; Guanosine Triphosphate; Kinetics; Mutation; Uridine Triphosphate

2002
Limited proteolysis of Escherichia coli cytidine 5'-triphosphate synthase. Identification of residues required for CTP formation and GTP-dependent activation of glutamine hydrolysis.
    European journal of biochemistry, 2003, Volume: 270, Issue:10

    Topics: Amino Acid Sequence; Arginine; Binding Sites; Carbon-Nitrogen Ligases; Catalysis; Circular Dichroism; Cytidine Triphosphate; Dimerization; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Escherichia coli; Glutaminase; Glutamine; Guanosine Triphosphate; Hydrolysis; Kinetics; Lysine; Models, Chemical; Models, Genetic; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Plasmids; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Proteins; Sequence Homology, Amino Acid; Time Factors; Trypsin

2003
Effects of mutagenesis of Gln97 in the switch II region of Escherichia coli elongation factor Tu on its interaction with guanine nucleotides, elongation factor Ts, and aminoacyl-tRNA.
    Biochemistry, 2003, Nov-25, Volume: 42, Issue:46

    Topics: Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Escherichia coli; Glutamine; Guanosine Diphosphate; Guanosine Triphosphate; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis; Peptide Elongation Factor Tu; Peptide Elongation Factors; Phenylalanine; Poly U; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; RNA, Transfer, Amino Acyl; Sequence Alignment; Sequence Homology, Amino Acid

2003
Competition between ammonia derived from internal glutamine hydrolysis and hydroxylamine present in the solution for incorporation into UTP as catalysed by Lactococcus lactis CTP synthase.
    Archives of biochemistry and biophysics, 2004, Apr-01, Volume: 424, Issue:1

    Topics: Ammonia; Binding, Competitive; Carbon-Nitrogen Ligases; Catalysis; Cytidine Triphosphate; Enzyme Inhibitors; Glutamates; Glutamine; Guanosine Triphosphate; Hydrolysis; Hydroxylamine; Kinetics; Lactococcus lactis; Protein Binding; Protein Subunits; Solutions; Uridine Triphosphate

2004
Inhibition of E. coli CTP synthase by the "positive" allosteric effector GTP.
    Biochimica et biophysica acta, 2004, Jun-01, Volume: 1699, Issue:1-2

    Topics: Allosteric Regulation; Ammonia; Carbon-Nitrogen Ligases; Cytidine Triphosphate; Escherichia coli; Glutaminase; Glutamine; Guanosine Triphosphate; Hydrolysis; Kinetics; Uridine Triphosphate

2004
Mutagenesis of glutamine 290 in Escherichia coli and mitochondrial elongation factor Tu affects interactions with mitochondrial aminoacyl-tRNAs and GTPase activity.
    Biochemistry, 2004, Jun-08, Volume: 43, Issue:22

    Topics: Amino Acid Sequence; Animals; Binding Sites; Cattle; Escherichia coli; Glutamine; GTP Phosphohydrolases; Guanosine Triphosphate; Leucine; Mitochondria; Molecular Sequence Data; Mutagenesis; Mutation; Peptide Elongation Factor Tu; Phenylalanine; Poly U; Protein Biosynthesis; Protein Conformation; Ribosomes; RNA, Transfer, Phe; Sequence Homology, Amino Acid

2004
The glutamine residue of the conserved GGQ motif in Saccharomyces cerevisiae release factor eRF1 is methylated by the product of the YDR140w gene.
    The Journal of biological chemistry, 2005, Jan-28, Volume: 280, Issue:4

    Topics: Amino Acid Motifs; Amino Acid Sequence; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Glutamine; Guanosine Triphosphate; Histidine; Mass Spectrometry; Methylation; Methyltransferases; Models, Molecular; Molecular Sequence Data; Peptide Termination Factors; Plasmids; Protein Binding; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2005
Prophylactic administration of topical glutamine enhances the capability of the rat colon to resist inflammatory damage.
    Digestive diseases and sciences, 2004, Volume: 49, Issue:10

    Topics: Adenosine Triphosphate; Administration, Topical; Animals; Chromatography, High Pressure Liquid; Colitis; Disease Models, Animal; Female; Glutamine; Glutathione; Guanosine Triphosphate; Intestinal Mucosa; Malondialdehyde; Mitotic Index; Rats; Rats, Inbred Strains

2004
Analysis of GTPases carrying hydrophobic amino acid substitutions in lieu of the catalytic glutamine: implications for GTP hydrolysis.
    Proteins, 2005, May-01, Volume: 59, Issue:2

    Topics: Amino Acid Substitution; Catalytic Domain; Glutamine; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Hydrolysis; Ligands; Models, Molecular; Protein Conformation; Protein Structure, Secondary

2005
Adenylyl cyclase Rv0386 from Mycobacterium tuberculosis H37Rv uses a novel mode for substrate selection.
    The FEBS journal, 2005, Volume: 272, Issue:12

    Topics: Adenosine Triphosphate; Adenylyl Cyclases; Amino Acid Sequence; Asparagine; Catalytic Domain; Glutamine; Guanosine Triphosphate; Isoenzymes; Molecular Sequence Data; Mutation; Mycobacterium tuberculosis; Substrate Specificity

2005
New insights into the role of conserved, essential residues in the GTP binding/GTP hydrolytic cycle of large G proteins.
    The Journal of biological chemistry, 2006, Apr-07, Volume: 281, Issue:14

    Topics: Arginine; Escherichia coli; Glutamine; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Hydrolysis; Mutagenesis, Site-Directed; Receptors, G-Protein-Coupled; Rhodopsin; Signal Transduction; Transducin

2006
Interactions of GTP with the ATP-grasp domain of GTP-specific succinyl-CoA synthetase.
    The Journal of biological chemistry, 2006, Apr-21, Volume: 281, Issue:16

    Topics: Adenosine Triphosphate; Animals; Arginine; Binding Sites; Crystallography, X-Ray; Glutamine; Guanine; Guanosine Triphosphate; Histidine; Hydrolysis; Models, Molecular; Nitrogen; Phosphates; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Conformation; Protein Isoforms; Ribose; Succinate-CoA Ligases; Swine

2006
Effects of a GTP-insensitive mutation of glutamate dehydrogenase on insulin secretion in transgenic mice.
    The Journal of biological chemistry, 2006, Jun-02, Volume: 281, Issue:22

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium Signaling; Glucose; Glutamate Dehydrogenase; Glutamine; Guanosine Triphosphate; Humans; Hyperinsulinism; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Leucine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Biological; Mutation; Recombinant Proteins

2006
Structural requirements for the activation of Escherichia coli CTP synthase by the allosteric effector GTP are stringent, but requirements for inhibition are lax.
    The Journal of biological chemistry, 2008, Jan-25, Volume: 283, Issue:4

    Topics: Adenosine Triphosphate; Allosteric Regulation; Allosteric Site; Ammonia; Carbon-Nitrogen Ligases; Enzyme Inhibitors; Escherichia coli; Glutamine; Guanosine Triphosphate; Purine Nucleosides; Uridine Triphosphate

2008
The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues.
    The EMBO journal, 2008, Apr-09, Volume: 27, Issue:7

    Topics: Amino Acid Sequence; Arginine; Binding Sites; Catalysis; Crystallography, X-Ray; Glutamine; GTPase-Activating Proteins; Guanosine Triphosphate; Hydrolysis; Models, Molecular; Molecular Sequence Data; Mutant Proteins; Protein Binding; Protein Structure, Secondary; rap1 GTP-Binding Proteins; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins

2008
Incorporation of tyrosine and glutamine residues into the soluble guanylate cyclase heme distal pocket alters NO and O2 binding.
    The Journal of biological chemistry, 2010, Jun-04, Volume: 285, Issue:23

    Topics: Amino Acid Sequence; Animals; Glutamine; Guanosine Triphosphate; Guanylate Cyclase; Heme; Kinetics; Molecular Sequence Data; Nitric Oxide; Oxygen; Porphyrins; Protein Binding; Rats; Receptors, Cytoplasmic and Nuclear; Sequence Homology, Amino Acid; Soluble Guanylyl Cyclase; Spectrophotometry; Tyrosine

2010
Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity.
    The EMBO journal, 2011, Aug-16, Volume: 30, Issue:20

    Topics: Amino Acid Sequence; Arginine; Bacterial Proteins; Catalysis; Catalytic Domain; Cell Polarity; Glutamine; Guanosine Triphosphate; Hydrolysis; Molecular Sequence Data; Myxococcus xanthus; Protein Conformation; ras Proteins

2011
Glutaminolysis activates Rag-mTORC1 signaling.
    Molecular cell, 2012, Aug-10, Volume: 47, Issue:3

    Topics: Animals; Autophagy; Glutamine; Guanosine Triphosphate; HEK293 Cells; HeLa Cells; Humans; Ketoglutaric Acids; Lysosomes; Mice; Monomeric GTP-Binding Proteins; Signal Transduction; Transcription Factors

2012
Catalytic mechanism of a mammalian Rab·RabGAP complex in atomic detail.
    Proceedings of the National Academy of Sciences of the United States of America, 2012, Dec-26, Volume: 109, Issue:52

    Topics: Animals; Biocatalysis; Catalytic Domain; DNA Mutational Analysis; Glutamine; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Hydrolysis; Kinetics; Mammals; Models, Molecular; rab1 GTP-Binding Proteins; Spectroscopy, Fourier Transform Infrared

2012
Structural basis unifying diverse GTP hydrolysis mechanisms.
    Biochemistry, 2013, Feb-12, Volume: 52, Issue:6

    Topics: Arginine; Binding Sites; Catalysis; Catalytic Domain; Glutamine; GTP Phosphohydrolases; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Hydrolysis; Models, Molecular; Protein Conformation; ras Proteins

2013
Glutamine deprivation initiates reversible assembly of mammalian rods and rings.
    Cellular and molecular life sciences : CMLS, 2014, Volume: 71, Issue:15

    Topics: Biosynthetic Pathways; Carbon-Nitrogen Ligases; Cytidine Triphosphate; Glutamate-Ammonia Ligase; Glutamine; Guanosine Triphosphate; HeLa Cells; Humans; IMP Dehydrogenase

2014
Why does mutation of Gln61 in Ras by the nitro analog NGln maintain activity of Ras-GAP in hydrolysis of guanosine triphosphate?
    Proteins, 2015, Volume: 83, Issue:11

    Topics: Glutamic Acid; Glutamine; Guanosine Triphosphate; Hydrolysis; Mutation; ras Proteins

2015
The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B.
    Scientific reports, 2016, Feb-23, Volume: 6

    Topics: Amino Acid Sequence; Arginine; Biocatalysis; Catalytic Domain; Gene Expression; Glutamine; Glycine; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Hydrolysis; Molecular Dynamics Simulation; Mutation; Neoplasm Proteins; Protein Structure, Secondary; Proto-Oncogene Proteins p21(ras)

2016
Ehrlichia secretes Etf-1 to induce autophagy and capture nutrients for its growth through RAB5 and class III phosphatidylinositol 3-kinase.
    Autophagy, 2016, Volume: 12, Issue:11

    Topics: Adenine; Animals; Autophagosomes; Autophagy; Autophagy-Related Protein 5; Bacterial Proteins; Beclin-1; Cell Membrane; Cell Proliferation; Class III Phosphatidylinositol 3-Kinases; Dogs; Ehrlichia chaffeensis; Ehrlichiosis; Enzyme Activation; Glutamic Acid; Glutamine; Guanosine Triphosphate; HEK293 Cells; Host-Pathogen Interactions; Humans; Huntingtin Protein; Inclusion Bodies; Mutant Proteins; Protein Binding; rab5 GTP-Binding Proteins; Signal Transduction; Sirolimus; Ubiquitination

2016
Structural plasticity mediates distinct GAP-dependent GTP hydrolysis mechanisms in Rab33 and Rab5.
    The FEBS journal, 2017, Volume: 284, Issue:24

    Topics: Amino Acid Sequence; Animals; Arginine; Catalysis; Catalytic Domain; Glutamine; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Kinetics; Mice; Models, Chemical; Models, Molecular; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Plasmodium falciparum; Protein Conformation; Protein Stability; Protozoan Proteins; rab GTP-Binding Proteins; rab1 GTP-Binding Proteins; rab5 GTP-Binding Proteins; Recombinant Fusion Proteins; Saccharomyces cerevisiae Proteins; Sequence Alignment; Structure-Activity Relationship

2017
Water Distribution within Wild-Type NRas Protein and Q61 Mutants during Unrestrained QM/MM Dynamics.
    Biophysical journal, 2018, 10-16, Volume: 115, Issue:8

    Topics: Binding Sites; Catalytic Domain; Glutamine; GTP Phosphohydrolases; Guanosine Triphosphate; Humans; Hydrogen Bonding; Hydrolysis; Membrane Proteins; Molecular Dynamics Simulation; Mutant Proteins; Mutation; Protein Conformation; Water

2018
Quantitative Measurement of Intrinsic GTP Hydrolysis for Carcinogenic Glutamine 61 Mutants in H-Ras.
    Biochemistry, 2018, 11-06, Volume: 57, Issue:44

    Topics: Carcinogens; Catalysis; Catalytic Domain; Glutamine; Guanosine Triphosphate; Humans; Hydrolysis; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Mutant Proteins; Mutation; Proto-Oncogene Proteins p21(ras)

2018
Atypical Switch-I Arginine plays a catalytic role in GTP hydrolysis by Rab21 from Entamoeba histolytica.
    Biochemical and biophysical research communications, 2018, 11-30, Volume: 506, Issue:3

    Topics: Amino Acid Motifs; Amino Acid Sequence; Arginine; Bacterial Proteins; Binding Sites; Biocatalysis; Entamoeba histolytica; Glutamine; Guanosine Triphosphate; Hydrolysis; Kinetics; Models, Molecular; Mutant Proteins; Protein Binding; rab GTP-Binding Proteins; Structure-Activity Relationship

2018
Catalytic site mutations confer multiple states of G protein activation.
    Science signaling, 2023, 02-14, Volume: 16, Issue:772

    Topics: Catalytic Domain; Glutamine; Guanosine Triphosphate; Heterotrimeric GTP-Binding Proteins; Mutation

2023
SLC25A21 downregulation promotes KRAS-mutant colorectal cancer progression by increasing glutamine anaplerosis.
    JCI insight, 2023, Nov-08, Volume: 8, Issue:21

    Topics: Cell Line, Tumor; Colorectal Neoplasms; Down-Regulation; Glutamine; Guanosine Triphosphate; Humans; Proto-Oncogene Proteins p21(ras)

2023