glutamine has been researched along with guanosine triphosphate in 73 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 16 (21.92) | 18.7374 |
1990's | 20 (27.40) | 18.2507 |
2000's | 21 (28.77) | 29.6817 |
2010's | 13 (17.81) | 24.3611 |
2020's | 3 (4.11) | 2.80 |
Authors | Studies |
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Henderson, JF; Smith, CM; Zombor, G | 1 |
Kane, JF; O'Brien, HD | 1 |
Goh, SH; Léjohn, HB | 1 |
Guder, WG; Schmidt, U | 1 |
Canioni, P; Labouesse, J; Merle, M; Pianet, I | 1 |
Langen, R; Schweins, T; Warshel, A | 1 |
Bourne, HR; Masters, SB; Zachary, I | 1 |
Lewis, DA; Villafranca, JJ | 1 |
Barrett, D; Breslau, NA; Downs, RW; Molinoff, PB; Wax, MB | 1 |
Bergamini, CM; Signorini, M | 1 |
Henshaw, EC; Panniers, R; Rowlands, AG; Scorsone, KA | 1 |
Buniatian, GKh | 1 |
Koshland, DE; Levitzki, A | 1 |
Atherly, AG; Barrett, A; Kaplan, S | 1 |
Koshland, DE; Levitzki, A; Stallcup, WB | 1 |
Smythies, JR | 1 |
Knowlton, RG; Yarus, M | 1 |
Eady, RR; Nair, MB | 1 |
Goldstein, L; Tullson, P | 1 |
Hilgenfeld, R | 1 |
Geyer, M; Kalbitzer, HR; Scheffzek, K; Schweins, T; Warshel, A; Wittinghofer, A | 1 |
Bocchini, V; Krab, IM; Parmeggiani, A; Scarano, G | 1 |
Erecińska, M; Nelson, D | 1 |
Berghuis, AM; Coleman, DE; Gilman, AG; Lee, E; Linder, ME; Sprang, SR | 1 |
Adeline, MT; Carman, GM; Flocco, MT; McDonough, VM; Ozier-Kalogeropoulos, O; Yang, WL | 1 |
Anderson, MW; Charifson, PS; Darden, TA; Foley, CK; Frech, M; Pedersen, LG; Wittinghofer, A | 1 |
Cullen, G; Dolphin, AC; Fazeli, MS; Huston, E; Pearson, H; Sweeney, MI | 1 |
Johnson, GL; Russell, M | 1 |
Allison, WS; Di Pietro, A; Divita, G; Jault, JM | 1 |
Birckbichler, PJ; Itoh, Y; Ohashi, H; Takeuchi, Y | 1 |
Schweins, T; Warshel, A | 1 |
Aktories, K; Mann, M; Schmidt, G; Sehr, P; Selzer, J; Wilm, M | 1 |
Boquet, P; Chardin, P; Fiorentini, C; Flatau, G; Gauthier, M; Lemichez, E; Paris, S | 1 |
Horiguchi, Y; Inoue, N; Kashimoto, T; Katahira, J; Masuda, M; Matsuda, M; Sugimoto, N | 1 |
Andorn, R; Chorev, M; Selinger, Z; Sofer, I; Zor, T | 1 |
Coleman, DE; Sprang, SR | 1 |
Bienengraeber, M; Echtay, KS; Klingenberg, M; Winkler, E | 1 |
Dixon, DA; Miller, JH; Resat, H; Straatsma, TP | 1 |
Anno, T; Furukawa, S; Inoue, H; Koga, M; Matsuo, K; Nakai, K; Ohta, Y; Oka, Y; Sasaki, T; Tanizawa, Y | 1 |
Brieba, LG; Padilla, R; Sousa, R | 1 |
Sigurskjold, BW; Willemoës, M | 1 |
Bearne, SL; Iyengar, A | 2 |
Bearne, SL; Hewitt, KA; Iyengar, A; Lunn, F; Simard, D | 1 |
Navratil, T; Spremulli, LL | 1 |
Willemoës, M | 1 |
Bearne, SL; Lunn, FA; MacDonnell, JE | 2 |
Hunter, SE; Spremulli, LL | 1 |
Buckingham, RH; Champ, S; Heurgué-Hamard, V; Kisselev, LL; Merkoulova-Rainon, T; Merkulova-Rainon, T; Mora, L | 1 |
Aptekar, L; Berenshtein, E; Goldin, E; Israeli, E; Kohen, R; Wengrower, D; Zajicek, G | 1 |
Gara, SK; Mishra, R; Mishra, S; Prakash, B | 1 |
Castro, LI; Hermsen, C; Linder, JU; Schultz, JE | 1 |
Cerione, RA; Majumdar, S; Ramachandran, S | 1 |
Brownie, ER; Fraser, ME; Hayakawa, K; Hume, MS; Ryan, DG | 1 |
Collins, HW; Daikhin, Y; Hsu, BY; Kelly, A; Kwagh, J; Lazarow, A; Li, C; MacMullen, C; Matschinsky, FM; Matter, A; Najafi, H; Nissim, I; Petty, TJ; Stanley, CA; Yudkoff, M | 1 |
Deaconescu, D; Scrima, A; Thomas, C; Wittinghofer, A | 1 |
Deng, S; Derbyshire, ER; Marletta, MA | 1 |
Hot, E; Keilberg, D; Koerner, C; Leonardy, S; Miertzschke, M; Søgaard-Andersen, L; Vetter, IR; Wittinghofer, A | 1 |
Durán, RV; Gottlieb, E; Hall, MN; Heiserich, L; Oppliger, W; Robitaille, AM; Skendaj, R | 1 |
Gavriljuk, K; Gazdag, EM; Gerwert, K; Goody, RS; Itzen, A; Kötting, C | 1 |
Anand, B; Majumdar, S; Prakash, B | 1 |
Calise, SJ; Carcamo, WC; Chan, EK; Krueger, C; Purich, DL; Yin, JD | 1 |
Grigorenko, BL; Khrenova, MG; Mironov, VA; Nemukhin, AV | 1 |
Jang, H; Lu, S; Nussinov, R; Zhang, J | 1 |
Cheng, Z; Lin, M; Liu, H; Niu, H; Rikihisa, Y; Xiong, Q; Yamamoto, A | 1 |
Acharya, A; Majumdar, S; Prakash, B | 1 |
Brut, M; Cabantous, S; Favre, G; Hemeryck, A; Landa, G; Tichauer, RH | 1 |
First, JT; Novelli, ET; Webb, LJ | 1 |
Chandra, M; Datta, S; Kotyada, C; Narooka, AR; Tripathi, A; Verma, A | 1 |
Bearne, SL; Guo, CJ; Liu, JL | 1 |
Arang, N; Campbell, SL; DiBerto, JF; Dohlman, HG; Ghosh, S; Gutkind, JS; Hewitt, N; Knight, KM; Ma, N; Martin, SA; Olsen, RHJ; Prakash, A; Roth, BL; Vaidehi, N | 1 |
Chen, H; Ding, YQ; Gao, JW; Han, Y; Hu, SS; Tan, TY; Wang, L; Wang, S; Wang, YQ; Yang, MH; Zhao, L | 1 |
2 review(s) available for glutamine and guanosine triphosphate
Article | Year |
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[Mechanisms of ammonia formation in the brain].
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Amino Acid Oxidoreductases; Amino Acids; Ammonia; Animals; Aspartic Acid; Brain; Brain Chemistry; Deamination; Dogs; Flavin-Adenine Dinucleotide; Fumarates; Glutamate Dehydrogenase; Glutaminase; Glutamine; Guanosine Triphosphate; Inosine Nucleotides; Mitochondria; Monoamine Oxidase; NAD; NADP; Nerve Tissue Proteins; Niacinamide; Oxidation-Reduction; Oxygen Consumption; Rats | 1973 |
GTP-Dependent Regulation of CTP Synthase: Evolving Insights into Allosteric Activation and NH
Topics: Adenosine Triphosphate; Allosteric Regulation; Carbon-Nitrogen Ligases; Cryoelectron Microscopy; Cytidine Triphosphate; Glutaminase; Glutamine; Guanosine Triphosphate; Nitric Oxide Synthase; Uridine Triphosphate | 2022 |
71 other study(ies) available for glutamine and guanosine triphosphate
Article | Year |
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Inhibitors of hypoxanthine metabolism in Ehrlich ascites tumor cells in vitro.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Carcinoma, Ehrlich Tumor; Cyclic GMP; Energy Metabolism; Glutamine; Guanine Nucleotides; Guanosine Triphosphate; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; In Vitro Techniques; Inosine Nucleotides; Ketone Oxidoreductases; Ligases; Lyases; Mice; Purines | 1976 |
p-Aminobenzoate-p-aminobenzoate.
Topics: Aminobenzoates; Ammonia; Bacillus subtilis; Chorismic Acid; Dose-Response Relationship, Drug; Edetic Acid; Glutamine; Guanosine; Guanosine Triphosphate; Hydrogen-Ion Concentration; Magnesium; Molecular Weight; Transaminases | 1975 |
Genetical and biochemical evidence that a novel dinucleoside polyphosphate coordinates salvage and de novo nucleotide biosynthetic pathways in mammalian cells.
Topics: Azaserine; Cell Line; Fluorouracil; Genes; Glutamine; Guanosine Triphosphate; Methotrexate; Mutation; Oligonucleotides; Oligoribonucleotides; Ribonucleotides | 1977 |
Substrate and oxygen dependence of renal metabolism.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Citric Acid Cycle; Dogs; Energy Metabolism; Energy Transfer; Glutamine; Glycolysis; Guanosine Triphosphate; Humans; Kidney; Mitochondria; Nephrons; Oxidation-Reduction; Oxygen Consumption; Palmitates; Pyruvate Dehydrogenase Complex; Pyruvates; Rabbits; Rats | 1976 |
Beta-adrenergic stimulation of C6 glioma cells: effects of cAMP overproduction on cellular metabolites. A multinuclear NMR study.
Topics: Adenosine Triphosphate; Animals; Carbon Isotopes; Cyclic AMP; Glioma; Glucose; Glutamates; Glutamine; Guanosine Triphosphate; Isoproterenol; Kinetics; Lactates; Magnetic Resonance Spectroscopy; Phosphorus; Phosphorylation; Receptors, Adrenergic, beta; Tumor Cells, Cultured | 1992 |
On the mechanism of guanosine triphosphate hydrolysis in ras p21 proteins.
Topics: Glutamine; GTP-Binding Proteins; Guanosine Triphosphate; Hydrolysis; Models, Molecular; Proto-Oncogene Proteins p21(ras); Structure-Activity Relationship; Thermodynamics; Water | 1992 |
Increased mitogenic responsiveness of Swiss 3T3 cells expressing constitutively active Gs alpha.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Cell Line; Cell Membrane; Cell Transformation, Neoplastic; Cyclic AMP; Enzyme Activation; Glutamine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Hydrolysis; Immunoblotting; Leucine; Mitogens; Molecular Sequence Data; Mutation; Thionucleotides; Transfection | 1990 |
Investigation of the mechanism of CTP synthetase using rapid quench and isotope partitioning methods.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Carbon-Nitrogen Ligases; Chemical Phenomena; Chemistry; Cytidine Triphosphate; Cytosine Nucleotides; Escherichia coli; Glutamine; Guanosine Triphosphate; Kinetics; Ligases; Phosphorus Radioisotopes; Phosphorylation; Uridine Triphosphate | 1989 |
New form of pseudohypoparathyroidism with abnormal catalytic adenylate cyclase.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Adult; Cell Line; Cell Membrane; Cyclic AMP; Fibroblasts; Glutamine; Guanosine Triphosphate; Humans; Isoproterenol; Pseudohypoparathyroidism; Reference Values; Skin | 1989 |
Calcium dependent reversible inactivation of erythrocyte transglutaminase by acrylamide.
Topics: Acrylamides; Calcium; Enzyme Activation; Enzyme Reactivators; Erythrocytes; Glutamine; Guanosine Triphosphate; Humans; Sulfhydryl Compounds; Time Factors; Transglutaminases | 1988 |
Phosphorylation of eukaryotic initiation factor 2 during physiological stresses which affect protein synthesis.
Topics: Cells, Cultured; Emetine; Eukaryotic Initiation Factor-2; Glucose; Glutamine; Guanine Nucleotide Exchange Factors; Guanosine Diphosphate; Guanosine Triphosphate; Hot Temperature; Peptide Initiation Factors; Phosphorylation; Protein Biosynthesis; Proteins | 1987 |
Role of an allosteric effector. Guanosine triphosphate activation in cytosine triphosphate synthetase.
Topics: Adenosine Triphosphate; Allosteric Regulation; Ammonia; Binding Sites; Carbon Isotopes; Cytosine Nucleotides; Dialysis; Enzyme Activation; Escherichia coli; Filtration; Glutaminase; Glutamine; Guanosine Triphosphate; Kinetics; Ligases; Macromolecular Substances; Mathematics; Models, Chemical; Protein Binding; Protein Conformation; Temperature; Tritium; Uracil Nucleotides | 1972 |
Synthesis of stable RNA in stringent Escherichia coli cells in the absence of charged transfer RNA.
Topics: Amino Acyl-tRNA Synthetases; Bacterial Proteins; Chloramphenicol; Escherichia coli; Fusidic Acid; Glutamine; Guanine Nucleotides; Guanosine Triphosphate; Mutation; RNA, Bacterial; RNA, Transfer; Temperature; Tetracycline; Tritium; Uracil; Valine | 1973 |
Half-of-the-sites reactivity and the conformational states of cytidine triphosphate synthetase.
Topics: Adenosine Triphosphate; Ammonia; Benzoates; Binding Sites; Carbon Isotopes; Chemical Phenomena; Chemistry; Cytosine Nucleotides; Diazooxonorleucine; Electrophoresis; Escherichia coli; Glutamine; Guanosine Triphosphate; Kinetics; Ligases; Macromolecular Substances; Magnesium; Models, Biological; Models, Structural; Molecular Weight; Nitro Compounds; Protein Binding; Protein Conformation; Uracil Nucleotides; Urea | 1971 |
Molecular mechanisms of adrenergic receptors.
Topics: Adenine; Adenosine Triphosphate; Adenylyl Cyclases; Benzene; Binding Sites; Catecholamines; Ergolines; Ergotamine; Glutamine; Guanosine Triphosphate; Macromolecular Substances; Models, Structural; Phentolamine; Phenylephrine; Prostaglandins; Receptors, Adrenergic; Receptors, Drug | 1972 |
Discrimination between aminoacyl groups on su+ 7 tRNA by elongation factor Tu.
Topics: Escherichia coli; Glutamine; Guanosine Triphosphate; Hydrogen-Ion Concentration; Kinetics; Peptide Elongation Factors; RNA, Bacterial; RNA, Transfer; RNA, Transfer, Amino Acyl; Suppression, Genetic; Tryptophan | 1980 |
Nitrogenase synthesis in Klebsiella pneumoniae: enhanced nif expression without accumulation of guanosine 5'-diphosphate 3'-diphosphate.
Topics: Adenosine Triphosphate; Gene Expression Regulation; Genes, Bacterial; Glutamine; Guanine Nucleotides; Guanosine Tetraphosphate; Guanosine Triphosphate; Klebsiella pneumoniae; Nitrogen Fixation; Nitrogenase; Transcription, Genetic | 1984 |
Allosteric regulation of renal alpha-ketoglutarate dehydrogenase.
Topics: Acidosis; Adenosine Diphosphate; Adenosine Triphosphate; Allosteric Regulation; Animals; Glutamine; Guanosine Triphosphate; Ketoglutarate Dehydrogenase Complex; Ketoglutaric Acids; Ketone Oxidoreductases; Kidney; Male; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1982 |
How do the GTPases really work?
Topics: Bacterial Proteins; Catalysis; Crystallography, X-Ray; Glutamine; GTP Phosphohydrolase-Linked Elongation Factors; Guanosine Triphosphate; Histidine; Hydrolysis; Models, Chemical; Peptide Elongation Factor Tu; Protein Conformation; Proto-Oncogene Proteins p21(ras); Protons; Structure-Activity Relationship; Thermus thermophilus; Water | 1995 |
Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins.
Topics: Amino Acid Sequence; Animals; Binding Sites; Catalysis; Cell Transformation, Neoplastic; Computer Simulation; Crystallography, X-Ray; Glutamine; GTP-Binding Proteins; GTPase-Activating Proteins; Guanosine Triphosphate; Hydrolysis; Insecta; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Binding; Protein Conformation; Proteins; Proto-Oncogene Proteins p21(ras); ras GTPase-Activating Proteins; Recombinant Fusion Proteins; Structure-Activity Relationship; Thermodynamics; Water | 1995 |
Relevance of histidine-84 in the elongation factor Tu GTPase activity and in poly(Phe) synthesis: its substitution by glutamine and alanine.
Topics: Alanine; Amino Acid Sequence; Cloning, Molecular; Escherichia coli; Glutamine; GTP Phosphohydrolase-Linked Elongation Factors; Guanosine Diphosphate; Guanosine Triphosphate; Histidine; Kinetics; Mutagenesis, Site-Directed; Peptide Biosynthesis; Peptide Elongation Factor Tu; Peptides; Point Mutation; Recombinant Proteins | 1995 |
Effects of 3-nitropropionic acid on synaptosomal energy and transmitter metabolism: relevance to neurodegenerative brain diseases.
Topics: Adenosine Triphosphate; Animals; Brain Diseases; Cell Death; Creatine; Energy Metabolism; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutamine; Guanosine Diphosphate; Guanosine Triphosphate; Lactates; Lactic Acid; Male; Neurotransmitter Agents; Nitro Compounds; Oxygen Consumption; Phosphocreatine; Propionates; Pyruvates; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Synaptosomes | 1994 |
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis.
Topics: Aluminum Compounds; Arginine; Binding Sites; Catalysis; Computer Graphics; Crystallography, X-Ray; Fluorides; Glutamine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Helix-Loop-Helix Motifs; Hydrogen Bonding; Hydrolysis; Models, Molecular; Protein Conformation; Protein Structure, Secondary | 1994 |
Purification and characterization of CTP synthetase, the product of the URA7 gene in Saccharomyces cerevisiae.
Topics: Base Sequence; Blotting, Western; Carbon-Nitrogen Ligases; Cloning, Molecular; Cytidine Triphosphate; Glutamine; Guanosine Triphosphate; Hydrogen-Ion Concentration; Kinetics; Ligases; Magnesium; Molecular Sequence Data; Precipitin Tests; Recombinant Proteins; Saccharomyces cerevisiae; Uridine Triphosphate | 1994 |
Role of glutamine-61 in the hydrolysis of GTP by p21H-ras: an experimental and theoretical study.
Topics: Binding Sites; Binding, Competitive; Escherichia coli; Glutamine; GTP Phosphohydrolases; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Guanosine Triphosphate; Hydrogen Bonding; Hydrolysis; Mutagenesis, Site-Directed; Proto-Oncogene Proteins p21(ras); Structure-Activity Relationship | 1994 |
Pertussis toxin treatment increases glutamate release and dihydropyridine binding sites in cultured rat cerebellar granule neurons.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Animals; Baclofen; Barium; Binding Sites; Calcium; Calcium Channels; Cells, Cultured; Cerebellum; Cyclic AMP; Dihydropyridines; Evoked Potentials; gamma-Aminobutyric Acid; Glutamates; Glutamine; GTP-Binding Proteins; Guanosine Triphosphate; Kinetics; Membrane Potentials; NAD; Neurons; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Virulence Factors, Bordetella | 1993 |
G protein amino-terminal alpha i2/alpha s chimeras reveal amino acids important in regulating alpha s activity.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Base Sequence; Cell Line; Cyclic AMP; Enzyme Activation; Glutamine; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Triphosphate; Lysine; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Recombinant Fusion Proteins; Sequence Alignment | 1993 |
Glutamine 170 to tyrosine substitution in yeast mitochondrial F1 beta-subunit increases catalytic site interaction with GDP and IDP and produces negative cooperativity of GTP and ITP hydrolysis.
Topics: Azides; Bicarbonates; Catalysis; Enzyme Activation; Glutamine; GTP Phosphohydrolases; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Hydrogen-Ion Concentration; Hydrolysis; Inosine Diphosphate; Inosine Nucleotides; Inosine Triphosphatase; Inosine Triphosphate; Mitochondria; Proton-Translocating ATPases; Pyrophosphatases; Schizosaccharomyces; Tyrosine | 1993 |
Purification and characterization of rat brain transglutaminase.
Topics: Affinity Labels; Animals; Binding Sites; Blotting, Western; Brain; Cations; Chromatography, Affinity; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Erythrocytes; Glutamine; Guanosine Triphosphate; Guinea Pigs; Humans; Kinetics; Liver; Lysine; Male; Molecular Weight; Rats; Rats, Sprague-Dawley; Transglutaminases | 1995 |
Mechanistic analysis of the observed linear free energy relationships in p21ras and related systems.
Topics: Catalysis; Deuterium; Glutamine; GTP Phosphohydrolases; GTP-Binding Proteins; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Mutagenesis, Site-Directed; Proteins; Proto-Oncogene Proteins p21(ras); Protons; ras GTPase-Activating Proteins; Solvents; Structure-Activity Relationship; Thermodynamics | 1996 |
Gln 63 of Rho is deamidated by Escherichia coli cytotoxic necrotizing factor-1.
Topics: 3T3 Cells; Actins; Adenosine Diphosphate Ribose; Amino Acid Sequence; Animals; Bacterial Toxins; Cytoskeleton; Cytotoxins; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Escherichia coli Proteins; Glutamine; Glycosylation; GTP Phosphohydrolases; GTP-Binding Proteins; GTPase-Activating Proteins; Guanosine Triphosphate; Mass Spectrometry; Mice; Microinjections; Molecular Sequence Data; Molecular Weight; ortho-Aminobenzoates; Recombinant Fusion Proteins; rhoA GTP-Binding Protein | 1997 |
Toxin-induced activation of the G protein p21 Rho by deamidation of glutamine.
Topics: Actins; Amino Acid Sequence; Animals; Bacterial Toxins; Chlorocebus aethiops; Cytoskeleton; Cytotoxins; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Escherichia coli Proteins; Glutamine; GTP Phosphohydrolases; GTP-Binding Proteins; GTPase-Activating Proteins; Guanosine Triphosphate; Kinetics; Molecular Sequence Data; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; Vero Cells | 1997 |
Bordetella bronchiseptica dermonecrotizing toxin induces reorganization of actin stress fibers through deamidation of Gln-63 of the GTP-binding protein Rho.
Topics: Actins; Amino Acid Sequence; Amino Acid Substitution; Animals; Bacterial Toxins; Bordetella bronchiseptica; Cell Line; Glutamic Acid; Glutamine; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Kinetics; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Recombinant Proteins; rhoA GTP-Binding Protein; Sequence Alignment; Transfection; Transglutaminases; Virulence Factors, Bordetella | 1997 |
GTP analogue hydrolysis by the Gs protein: implication for the role of catalytic glutamine in the GTPase reaction.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Animals; Cell Membrane; Glutamine; GTP Phosphohydrolases; GTP-Binding Protein alpha Subunits, Gs; Guanosine Triphosphate; Hydrolysis; Kinetics; Parotid Gland; Rats; Substrate Specificity | 1998 |
Structure of Gialpha1.GppNHp, autoinhibition in a galpha protein-substrate complex.
Topics: Animals; Catalytic Domain; Computer Simulation; Crystallography, X-Ray; Glutamine; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guanylyl Imidodiphosphate; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Rats; Recombinant Proteins | 1999 |
Site-directed mutagenesis identifies residues in uncoupling protein (UCP1) involved in three different functions.
Topics: Adipose Tissue, Brown; Amino Acid Substitution; Animals; Asparagine; Aspartic Acid; Binding Sites; Carrier Proteins; Chlorides; Cricetinae; Electron Transport; Glutamic Acid; Glutamine; Guanosine Triphosphate; Ion Channels; Membrane Proteins; Mitochondria; Mitochondrial Proteins; Mutagenesis, Site-Directed; Protons; Saccharomyces cerevisiae; Uncoupling Agents; Uncoupling Protein 1 | 2000 |
The arginine finger of RasGAP helps Gln-61 align the nucleophilic water in GAP-stimulated hydrolysis of GTP.
Topics: Arginine; Binding Sites; Cluster Analysis; Glutamine; Guanosine Triphosphate; Hydrolysis; p120 GTPase Activating Protein; Proto-Oncogene Proteins p21(ras); Water | 2001 |
Unregulated elevation of glutamate dehydrogenase activity induces glutamine-stimulated insulin secretion: identification and characterization of a GLUD1 gene mutation and insulin secretion studies with MIN6 cells overexpressing the mutant glutamate dehydr
Topics: Adenosine Diphosphate; Animals; Blood Glucose; COS Cells; DNA Mutational Analysis; Female; Glucose; Glutamate Dehydrogenase; Glutamine; Guanosine Triphosphate; Humans; Hyperinsulinism; Hypoglycemia; Infant; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Mutation; Pancreatic Neoplasms; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Transfection; Tumor Cells, Cultured | 2002 |
Role of T7 RNA polymerase His784 in start site selection and initial transcription.
Topics: Alanine; Bacteriophage T7; Base Sequence; Binding Sites; DNA-Directed RNA Polymerases; Glutamine; Guanosine; Guanosine Triphosphate; Histidine; Hydrogen Bonding; Mutagenesis, Site-Directed; Promoter Regions, Genetic; Stereoisomerism; Transcription Initiation Site; Viral Proteins | 2002 |
Steady-state kinetics of the glutaminase reaction of CTP synthase from Lactococcus lactis. The role of the allosteric activator GTP incoupling between glutamine hydrolysis and CTP synthesis.
Topics: Allosteric Regulation; Calorimetry; Carbon-Nitrogen Ligases; Cytidine Triphosphate; Glutaminase; Glutamine; Guanosine Triphosphate; Hydrolysis; Kinetics; Lactococcus lactis; Models, Biological | 2002 |
Aspartate-107 and leucine-109 facilitate efficient coupling of glutamine hydrolysis to CTP synthesis by Escherichia coli CTP synthase.
Topics: Alanine; Amino Acid Sequence; Aspartic Acid; Carbon-Nitrogen Ligases; Circular Dichroism; Conserved Sequence; Cytidine Triphosphate; Dimerization; Escherichia coli Proteins; Glutamine; Guanosine Triphosphate; Hydrolysis; Leucine; Molecular Sequence Data; Mutagenesis, Site-Directed | 2003 |
An assay for cytidine 5(')-triphosphate synthetase glutaminase activity using high performance liquid chromatography.
Topics: Adenosine Triphosphate; Carbon-Nitrogen Ligases; Chromatography, High Pressure Liquid; Colorimetry; Cytidine Triphosphate; Glutaminase; Glutamine; Guanosine Triphosphate; Kinetics; Mutation; Uridine Triphosphate | 2002 |
Limited proteolysis of Escherichia coli cytidine 5'-triphosphate synthase. Identification of residues required for CTP formation and GTP-dependent activation of glutamine hydrolysis.
Topics: Amino Acid Sequence; Arginine; Binding Sites; Carbon-Nitrogen Ligases; Catalysis; Circular Dichroism; Cytidine Triphosphate; Dimerization; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Escherichia coli; Glutaminase; Glutamine; Guanosine Triphosphate; Hydrolysis; Kinetics; Lysine; Models, Chemical; Models, Genetic; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Plasmids; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Proteins; Sequence Homology, Amino Acid; Time Factors; Trypsin | 2003 |
Effects of mutagenesis of Gln97 in the switch II region of Escherichia coli elongation factor Tu on its interaction with guanine nucleotides, elongation factor Ts, and aminoacyl-tRNA.
Topics: Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Escherichia coli; Glutamine; Guanosine Diphosphate; Guanosine Triphosphate; Kinetics; Models, Molecular; Molecular Sequence Data; Mutagenesis; Peptide Elongation Factor Tu; Peptide Elongation Factors; Phenylalanine; Poly U; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; RNA, Transfer, Amino Acyl; Sequence Alignment; Sequence Homology, Amino Acid | 2003 |
Competition between ammonia derived from internal glutamine hydrolysis and hydroxylamine present in the solution for incorporation into UTP as catalysed by Lactococcus lactis CTP synthase.
Topics: Ammonia; Binding, Competitive; Carbon-Nitrogen Ligases; Catalysis; Cytidine Triphosphate; Enzyme Inhibitors; Glutamates; Glutamine; Guanosine Triphosphate; Hydrolysis; Hydroxylamine; Kinetics; Lactococcus lactis; Protein Binding; Protein Subunits; Solutions; Uridine Triphosphate | 2004 |
Inhibition of E. coli CTP synthase by the "positive" allosteric effector GTP.
Topics: Allosteric Regulation; Ammonia; Carbon-Nitrogen Ligases; Cytidine Triphosphate; Escherichia coli; Glutaminase; Glutamine; Guanosine Triphosphate; Hydrolysis; Kinetics; Uridine Triphosphate | 2004 |
Mutagenesis of glutamine 290 in Escherichia coli and mitochondrial elongation factor Tu affects interactions with mitochondrial aminoacyl-tRNAs and GTPase activity.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cattle; Escherichia coli; Glutamine; GTP Phosphohydrolases; Guanosine Triphosphate; Leucine; Mitochondria; Molecular Sequence Data; Mutagenesis; Mutation; Peptide Elongation Factor Tu; Phenylalanine; Poly U; Protein Biosynthesis; Protein Conformation; Ribosomes; RNA, Transfer, Phe; Sequence Homology, Amino Acid | 2004 |
The glutamine residue of the conserved GGQ motif in Saccharomyces cerevisiae release factor eRF1 is methylated by the product of the YDR140w gene.
Topics: Amino Acid Motifs; Amino Acid Sequence; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Glutamine; Guanosine Triphosphate; Histidine; Mass Spectrometry; Methylation; Methyltransferases; Models, Molecular; Molecular Sequence Data; Peptide Termination Factors; Plasmids; Protein Binding; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2005 |
Prophylactic administration of topical glutamine enhances the capability of the rat colon to resist inflammatory damage.
Topics: Adenosine Triphosphate; Administration, Topical; Animals; Chromatography, High Pressure Liquid; Colitis; Disease Models, Animal; Female; Glutamine; Glutathione; Guanosine Triphosphate; Intestinal Mucosa; Malondialdehyde; Mitotic Index; Rats; Rats, Inbred Strains | 2004 |
Analysis of GTPases carrying hydrophobic amino acid substitutions in lieu of the catalytic glutamine: implications for GTP hydrolysis.
Topics: Amino Acid Substitution; Catalytic Domain; Glutamine; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Hydrolysis; Ligands; Models, Molecular; Protein Conformation; Protein Structure, Secondary | 2005 |
Adenylyl cyclase Rv0386 from Mycobacterium tuberculosis H37Rv uses a novel mode for substrate selection.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Amino Acid Sequence; Asparagine; Catalytic Domain; Glutamine; Guanosine Triphosphate; Isoenzymes; Molecular Sequence Data; Mutation; Mycobacterium tuberculosis; Substrate Specificity | 2005 |
New insights into the role of conserved, essential residues in the GTP binding/GTP hydrolytic cycle of large G proteins.
Topics: Arginine; Escherichia coli; Glutamine; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Diphosphate; Guanosine Triphosphate; Hydrolysis; Mutagenesis, Site-Directed; Receptors, G-Protein-Coupled; Rhodopsin; Signal Transduction; Transducin | 2006 |
Interactions of GTP with the ATP-grasp domain of GTP-specific succinyl-CoA synthetase.
Topics: Adenosine Triphosphate; Animals; Arginine; Binding Sites; Crystallography, X-Ray; Glutamine; Guanine; Guanosine Triphosphate; Histidine; Hydrolysis; Models, Molecular; Nitrogen; Phosphates; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Conformation; Protein Isoforms; Ribose; Succinate-CoA Ligases; Swine | 2006 |
Effects of a GTP-insensitive mutation of glutamate dehydrogenase on insulin secretion in transgenic mice.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium Signaling; Glucose; Glutamate Dehydrogenase; Glutamine; Guanosine Triphosphate; Humans; Hyperinsulinism; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Leucine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Biological; Mutation; Recombinant Proteins | 2006 |
Structural requirements for the activation of Escherichia coli CTP synthase by the allosteric effector GTP are stringent, but requirements for inhibition are lax.
Topics: Adenosine Triphosphate; Allosteric Regulation; Allosteric Site; Ammonia; Carbon-Nitrogen Ligases; Enzyme Inhibitors; Escherichia coli; Glutamine; Guanosine Triphosphate; Purine Nucleosides; Uridine Triphosphate | 2008 |
The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues.
Topics: Amino Acid Sequence; Arginine; Binding Sites; Catalysis; Crystallography, X-Ray; Glutamine; GTPase-Activating Proteins; Guanosine Triphosphate; Hydrolysis; Models, Molecular; Molecular Sequence Data; Mutant Proteins; Protein Binding; Protein Structure, Secondary; rap1 GTP-Binding Proteins; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins | 2008 |
Incorporation of tyrosine and glutamine residues into the soluble guanylate cyclase heme distal pocket alters NO and O2 binding.
Topics: Amino Acid Sequence; Animals; Glutamine; Guanosine Triphosphate; Guanylate Cyclase; Heme; Kinetics; Molecular Sequence Data; Nitric Oxide; Oxygen; Porphyrins; Protein Binding; Rats; Receptors, Cytoplasmic and Nuclear; Sequence Homology, Amino Acid; Soluble Guanylyl Cyclase; Spectrophotometry; Tyrosine | 2010 |
Structural analysis of the Ras-like G protein MglA and its cognate GAP MglB and implications for bacterial polarity.
Topics: Amino Acid Sequence; Arginine; Bacterial Proteins; Catalysis; Catalytic Domain; Cell Polarity; Glutamine; Guanosine Triphosphate; Hydrolysis; Molecular Sequence Data; Myxococcus xanthus; Protein Conformation; ras Proteins | 2011 |
Glutaminolysis activates Rag-mTORC1 signaling.
Topics: Animals; Autophagy; Glutamine; Guanosine Triphosphate; HEK293 Cells; HeLa Cells; Humans; Ketoglutaric Acids; Lysosomes; Mice; Monomeric GTP-Binding Proteins; Signal Transduction; Transcription Factors | 2012 |
Catalytic mechanism of a mammalian Rab·RabGAP complex in atomic detail.
Topics: Animals; Biocatalysis; Catalytic Domain; DNA Mutational Analysis; Glutamine; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Hydrolysis; Kinetics; Mammals; Models, Molecular; rab1 GTP-Binding Proteins; Spectroscopy, Fourier Transform Infrared | 2012 |
Structural basis unifying diverse GTP hydrolysis mechanisms.
Topics: Arginine; Binding Sites; Catalysis; Catalytic Domain; Glutamine; GTP Phosphohydrolases; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Hydrolysis; Models, Molecular; Protein Conformation; ras Proteins | 2013 |
Glutamine deprivation initiates reversible assembly of mammalian rods and rings.
Topics: Biosynthetic Pathways; Carbon-Nitrogen Ligases; Cytidine Triphosphate; Glutamate-Ammonia Ligase; Glutamine; Guanosine Triphosphate; HeLa Cells; Humans; IMP Dehydrogenase | 2014 |
Why does mutation of Gln61 in Ras by the nitro analog NGln maintain activity of Ras-GAP in hydrolysis of guanosine triphosphate?
Topics: Glutamic Acid; Glutamine; Guanosine Triphosphate; Hydrolysis; Mutation; ras Proteins | 2015 |
The Structural Basis of Oncogenic Mutations G12, G13 and Q61 in Small GTPase K-Ras4B.
Topics: Amino Acid Sequence; Arginine; Biocatalysis; Catalytic Domain; Gene Expression; Glutamine; Glycine; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Hydrolysis; Molecular Dynamics Simulation; Mutation; Neoplasm Proteins; Protein Structure, Secondary; Proto-Oncogene Proteins p21(ras) | 2016 |
Ehrlichia secretes Etf-1 to induce autophagy and capture nutrients for its growth through RAB5 and class III phosphatidylinositol 3-kinase.
Topics: Adenine; Animals; Autophagosomes; Autophagy; Autophagy-Related Protein 5; Bacterial Proteins; Beclin-1; Cell Membrane; Cell Proliferation; Class III Phosphatidylinositol 3-Kinases; Dogs; Ehrlichia chaffeensis; Ehrlichiosis; Enzyme Activation; Glutamic Acid; Glutamine; Guanosine Triphosphate; HEK293 Cells; Host-Pathogen Interactions; Humans; Huntingtin Protein; Inclusion Bodies; Mutant Proteins; Protein Binding; rab5 GTP-Binding Proteins; Signal Transduction; Sirolimus; Ubiquitination | 2016 |
Structural plasticity mediates distinct GAP-dependent GTP hydrolysis mechanisms in Rab33 and Rab5.
Topics: Amino Acid Sequence; Animals; Arginine; Catalysis; Catalytic Domain; Glutamine; GTPase-Activating Proteins; Guanosine Triphosphate; Humans; Kinetics; Mice; Models, Chemical; Models, Molecular; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Plasmodium falciparum; Protein Conformation; Protein Stability; Protozoan Proteins; rab GTP-Binding Proteins; rab1 GTP-Binding Proteins; rab5 GTP-Binding Proteins; Recombinant Fusion Proteins; Saccharomyces cerevisiae Proteins; Sequence Alignment; Structure-Activity Relationship | 2017 |
Water Distribution within Wild-Type NRas Protein and Q61 Mutants during Unrestrained QM/MM Dynamics.
Topics: Binding Sites; Catalytic Domain; Glutamine; GTP Phosphohydrolases; Guanosine Triphosphate; Humans; Hydrogen Bonding; Hydrolysis; Membrane Proteins; Molecular Dynamics Simulation; Mutant Proteins; Mutation; Protein Conformation; Water | 2018 |
Quantitative Measurement of Intrinsic GTP Hydrolysis for Carcinogenic Glutamine 61 Mutants in H-Ras.
Topics: Carcinogens; Catalysis; Catalytic Domain; Glutamine; Guanosine Triphosphate; Humans; Hydrolysis; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Mutant Proteins; Mutation; Proto-Oncogene Proteins p21(ras) | 2018 |
Atypical Switch-I Arginine plays a catalytic role in GTP hydrolysis by Rab21 from Entamoeba histolytica.
Topics: Amino Acid Motifs; Amino Acid Sequence; Arginine; Bacterial Proteins; Binding Sites; Biocatalysis; Entamoeba histolytica; Glutamine; Guanosine Triphosphate; Hydrolysis; Kinetics; Models, Molecular; Mutant Proteins; Protein Binding; rab GTP-Binding Proteins; Structure-Activity Relationship | 2018 |
Catalytic site mutations confer multiple states of G protein activation.
Topics: Catalytic Domain; Glutamine; Guanosine Triphosphate; Heterotrimeric GTP-Binding Proteins; Mutation | 2023 |
SLC25A21 downregulation promotes KRAS-mutant colorectal cancer progression by increasing glutamine anaplerosis.
Topics: Cell Line, Tumor; Colorectal Neoplasms; Down-Regulation; Glutamine; Guanosine Triphosphate; Humans; Proto-Oncogene Proteins p21(ras) | 2023 |