glutamine has been researched along with glutaminase in 854 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 316 (37.00) | 18.7374 |
| 1990's | 132 (15.46) | 18.2507 |
| 2000's | 94 (11.01) | 29.6817 |
| 2010's | 197 (23.07) | 24.3611 |
| 2020's | 115 (13.47) | 2.80 |
| Authors | Studies |
|---|---|
| Banks, GT; Bascomb, S; Bettelheim, KA; Fleming, A; Skarstedt, MT | 1 |
| Byrne, D; Preuss, HG; Shim, PS | 1 |
| Alleyne, GA; Bennett, FI; McFarlane Anderson, N | 1 |
| Goldstein, L | 5 |
| Kunin, AS; Tannen, RL | 1 |
| Phenix, P; Thornley-Brown, C; Welbourne, CJ; Welbourne, TC | 1 |
| Badr El-Din, SM; Foda, MS | 1 |
| Campbell, JW; Vorhaben, JE | 1 |
| Geary, LE; Meister, A | 1 |
| Khachatrian, SA; Papian, AA | 1 |
| Truitt, CD; Zalkin, H | 1 |
| Seegmiller, JE; Willis, RC | 1 |
| Fonda, ML; Kirzinger, SS | 1 |
| Tannen, RL | 1 |
| Welbourne, TC | 5 |
| Agarwal, KN; Devi, R; Prasad, C | 1 |
| Nordmann, J; Nordmann, R; Petit, MA | 3 |
| Leusen, I; Van Leuven, F; Weyne, J | 1 |
| Nordmann, J; Nordmann, R; Pett, MA | 1 |
| Affonso, OR; Mitidieri, E; Santos, LJ | 1 |
| Epstein, FH; Narins, R; Relman, AS; Stoff, JS | 1 |
| Kane, JF; Moyed, HS; Patel, N | 1 |
| Franklin, C; Goldstein, L | 1 |
| Meister, A | 1 |
| Cornblath, M; Ozand, PT; Stevenson, JH; Tildon, JT | 1 |
| Furlong, CE; Iwata, KK; Willis, RC | 1 |
| Prusiner, S | 1 |
| Hoffman, PM; Klahr, S; Sandler, RS; Schoolwerth, AC | 1 |
| Cooper, AJ; Meister, A | 1 |
| Bernlohr, RW; Corrigan, MG; Donohue, TJ; Kalb, VF | 1 |
| Clark, VM; Curthoys, NP; Shapiro, RA | 1 |
| Hertz, L; Kvamme, E; Schousboe, A; Svenneby, G | 1 |
| Chiang, GH; Cotman, CW; Hamberger, A; Sandoval, E | 1 |
| Roberts, J; Rosenfeld, HJ; Schmid, FA | 1 |
| Holcenberg, JS | 2 |
| Abuchowski, A; Davis, FF; McCoy, JR; Palczuk, NC; van Es, T | 1 |
| Baverel, G; Lund, P | 1 |
| Makarewicz, W; Swierczyński, J | 1 |
| Brosnan, JT; Squires, EJ | 1 |
| Holcenberg, JS; Roberts, J; Schmer, G | 1 |
| McGale, HF; Pye, IF; Stonier, C | 1 |
| Curthoys, NP; Shapiro, RA | 2 |
| Bradford, HF; Thomas, AJ; Ward, HK | 1 |
| Brosnan, JT; Hall, B; McPhee, P; Parry, DM | 1 |
| Nilova, NS | 1 |
| Frick, A; Imler, M; Schlienger, JL; Stahl, A | 1 |
| Brosnan, JT; Parry, DM | 2 |
| Blackburn, AB; Moore, JJ; Sax, SM | 1 |
| Rabinovitz, M; Rabon, A; Vistica, DT | 1 |
| Joseph, SK; McGivan, JD | 1 |
| Mantsala, P; Zalkin, H | 1 |
| Spiers, AS; Wade, HE | 1 |
| Clark, JB; Dennis, SC; Lai, JC | 1 |
| Pinkus, LM; Windmueller, HG | 1 |
| Kovacević, Z | 2 |
| Aptekar', IS | 1 |
| Baechtel, FS; Gregg, DE; Prager, MD | 1 |
| Dolowy, WC; Holcenberg, JS; Tang, E | 1 |
| Simpson, DP | 2 |
| Phenix, P; Welbourne, TC | 1 |
| Adam, WR; Brown, S | 1 |
| Krebs, HA | 1 |
| Raabe, W | 1 |
| Cattano, C; Nissim, I; Yudkoff, M | 1 |
| Goto, I; Matsuno, T | 1 |
| Austgen, TR; Chakrabarti, R; Chen, MK; Souba, WW | 1 |
| Cattaneo, MV; Luong, JH; Mercille, S | 1 |
| Austgen, TR; Pacitti, AJ; Souba, WW | 1 |
| Erecińska, M; Michalik, M; Nelson, J | 1 |
| Munoz, S; Murphy, S; Newsholme, E; Parry-Billings, M | 1 |
| Calderwood-Mays, M; Duckworth, DH; Madison, JB; Souba, WW | 1 |
| Curi, R; Cury, Y; Rosa, LF | 1 |
| Baverel, G; Martin, G; Vincent, N | 2 |
| Erecińska, M; Nelson, D; Rumsey, WL | 2 |
| Roux, B; Walsh, CT | 1 |
| Austgen, TR; Chen, MK; Moore, W; Souba, WW | 1 |
| Ardawi, MS; Majzoub, MF | 1 |
| Ballantyne, JS; Chamberlin, ME; Glemet, HC | 1 |
| Sun, YW | 1 |
| Babij, P; Hundal, HS; Rennie, MJ; Taylor, PM; Watt, PW | 1 |
| Curti, B; Edmondson, DE; Rescigno, M; Vanoni, MA; Zanetti, G | 1 |
| Casado, J; Felipe, A; Pastor-Anglada, M; Ruiz, B | 1 |
| Erecińska, M; Nelson, D; Osbakken, M; Zhang, DN | 1 |
| Ardawi, MS | 3 |
| Katunuma, N | 1 |
| Watford, M | 2 |
| Austgen, TR; Chen, MK; Copeland, EM; Dudrick, PS; Souba, WW | 1 |
| Curi, CM; Curi, R; Fernandes, LC; Ursini, F; Vugman, M | 1 |
| Nissim, I; Yudkoff, M | 1 |
| Klimberg, S | 1 |
| Salloum, RM; Souba, WW; Stevens, BR | 1 |
| Chang, SH; Miran, SG; Raushel, FM | 1 |
| Battaglioli, G; Martin, DL | 1 |
| Erecińska, M; Nelson, D; Nissim, I; Yudkoff, M; Zaleska, MM | 1 |
| Chung, GH; Lee, HJ; Yang, KH | 1 |
| da Fonseca-Wollheim, F | 1 |
| Ardawi, MS; Jamal, YS | 1 |
| Jayaprada, P; Rao, KV; Reddy, MS | 1 |
| Azoulay, M; Frappier, F; Vilmont, M | 1 |
| Bajin, K; Brkljac, O; Kovacević, Z | 1 |
| Baracos, VE; Thompson, JR; Wu, GY | 1 |
| Copeland, EM; Salloum, RM; Souba, WW | 1 |
| Kvamme, E; Roberg, B; Torgner, IA | 5 |
| Costa Rosa, LF; Curi, R; Cury, Y | 1 |
| Ardawi, MS; Kateilah, SM; Majzoub, MF; Newsholme, EA | 1 |
| Baverel, G; Besson, J; Durozard, D; Martin, G | 1 |
| Atkinson, DE; Szweda, LI | 2 |
| Copeland, EM; Dolson, DJ; Hautamaki, RD; Holley, DT; Klimberg, VS; Salloum, RM; Souba, WW | 1 |
| Braddock, P; Brindle, KM; Sri-Pathmanathan, RM | 1 |
| Copeland, EM; Flynn, TC; Herskowitz, K; Klimberg, VS; Plumley, DA; Salloum, RM; Souba, WW | 1 |
| Alleyne, GA; García-Salguero, L; Hortelano, P; Lupiáñez, JA | 1 |
| Scheller, D; Silbernagl, S | 1 |
| Keast, D; Newsholme, EA; Nguyen, T | 1 |
| Häussinger, D | 5 |
| Baverel, G; Martin, G; Michoudet, C | 1 |
| Kelso, TB; Max, SR; Shear, CR | 1 |
| Abdul-Ghani, AS; el-Lati, S; Ghneim, H; Saca'an, A | 1 |
| Sastrasinh, M; Sastrasinh, S | 2 |
| González, A; Olamendi, J; Rodríguez, L; Soberón, M | 1 |
| Curi, R; Newsholme, EA | 1 |
| Baab, PJ; Landry, ME; Tildon, JT; Zielke, CL; Zielke, HR | 1 |
| Beil, W; Sewing, KF; Staar, U | 1 |
| Durschlag, RP; Smith, RJ | 1 |
| Gerok, W; Häussinger, D; Stehle, T | 1 |
| Gerok, W; Häussinger, D; Sies, H | 2 |
| Cooper, AJ; Gelbard, AS; Roberts, J; Rosenspire, KC; Schmid, FA | 1 |
| Mehlhaff, PM; Pfeiffer, NE; Schuster, SM; Wylie, DE | 1 |
| Chandrakala, MV; Marcus, SR; Nadiger, HA; Rao, TI; Sadasivudu, B | 1 |
| Matsuno, T; Satoh, T | 1 |
| Meijer, AJ; Verhoeven, AJ | 1 |
| Svenneby, G; Torgner, IA | 1 |
| Márquez, J; Medina, MA; Núñez de Castro, I; Quesada, AR; Sánchez-Jiménez, FM | 1 |
| Curi, R; Kowalchuk, JM; Newsholme, EA | 1 |
| Bowen, DM; Esiri, MM; Francis, PT; Hunt, A; Lowe, SL; Najlerahim, A; Palmer, AM; Patel, AJ; Procter, AW; Stratmann, GC | 1 |
| Nissim, I; Pleasure, D; Yudkoff, M | 1 |
| Casado, J; Felipe, A; Pastor-Anglada, M; Remesar, X | 1 |
| Matsuno, T; Satoh, T; Suzuki, H | 1 |
| Albajar, M; Hems, R; Klim, RA; Williamson, DH | 1 |
| Kretchmer, N; Nagy, LE | 2 |
| Avila, J; Montejo de Garcini, E; Serrano, L | 1 |
| Marquez, J; Medina, MA; Nuñez de Castro, I; Perez-Rodriguez, J; Quesada, AR; Sanchez-Jimenez, F | 1 |
| González, A; Soberón, M | 1 |
| Bowen, DM; Doshi, R; Francis, PT; Lowe, SL; Murphy, E; Neary, D; Palmer, AM; Procter, AW | 1 |
| Ardawi, MS; Newshalme, EA | 1 |
| Erbelding, EJ; Smith, EM; Watford, M | 2 |
| Huber, KR; Mayer, EP; Mitchell, DF; Roberts, J | 1 |
| Curi, R; Hussein, A; Leighton, B; Newsholme, EA | 1 |
| Roberts, J; Steele, D; Tannock, IF | 1 |
| Amuro, N; Paluh, JL; Zalkin, H | 1 |
| Ardawi, MS; Crabtree, B; Newsholme, EA | 1 |
| Bradford, N; Lacey, J; McGivan, J; Vadher, M | 1 |
| Kizaki, H; Ohsaka, F; Sakurada, T | 1 |
| Kvamme, E; Svenneby, G; Torgner, IA; Tveter, KJ | 1 |
| O'Donovan, DJ | 3 |
| Endou, H; Nakada, J; Nonoguchi, H; Takehara, Y; Yamada, H | 1 |
| Levental, M; Rakić, L; Rusić, M | 1 |
| Deriabina, TI; Savel'eva, SN | 1 |
| Katunuma, N; Kobayashi, K; Kuroda, Y; Matsuda, Y | 1 |
| Evtushenko, GI; Kolodub, FA | 1 |
| Ching, S; Gabuzda, GJ; Rogoff, TM | 1 |
| Meister, A; Tate, SS | 1 |
| Buniatian, GKh | 1 |
| Knöfel, R; Rost, J | 1 |
| Martínez-Rodriguez, R | 1 |
| Fetisova, TV; Zabolotniuk, IP | 1 |
| Horowitz, ML; Knox, WE | 1 |
| Goodman, AD; Pagliara, AS | 1 |
| Morris, HP; Wu, C | 1 |
| Henderson, EJ; Nagano, H; Zalkin, H | 1 |
| Buttery, PJ; Rowsell, EV | 2 |
| Nahorski, SR | 1 |
| Haschemeyer, RH; Meister, A; Pinkus, LM; Trotta, PP | 1 |
| Meister, A; Pinkus, LM; Trotta, PP | 1 |
| Even, HL; Larimore, F; Roon, RJ | 1 |
| Brand, MD; Chappell, JB | 1 |
| Burg, M; Orloff, J | 1 |
| Prusiner, S; Stadtman, ER | 1 |
| Ababei, L; Hăulică, A; Trandafirescu, M | 1 |
| Carter, SK; Cooney, DA; Livingston, RB; Venditti, JM | 1 |
| Peterkofsky, A; Twardzik, DR | 1 |
| Kovacević, Z; Morris, HP | 1 |
| Bourgoignie, JJ; Klahr, S; Schoolwerth, AC | 1 |
| Matsuda, Y | 1 |
| Berberich, MA | 1 |
| Miller, RE; Prusiner, S; Valentine, RC | 1 |
| Lingundi, MM; Rost, J | 1 |
| Kvamme, E; Torgner, IA | 1 |
| Chakraborty, P; Shrivastava, GC | 1 |
| Chakraborty, P; Chowdhuri, MD; Shrivastava, GC | 1 |
| Koshland, DE; Levitzki, A | 1 |
| Srinivasan, PR; Tamir, H | 1 |
| Varricchio, F | 1 |
| Anderson, PM; Meister, A; Wellner, VP | 1 |
| Meister, A; Pinkus, LM; Trotta, PP; Wellner, VP | 1 |
| Novak, EK; Phillips, AW | 1 |
| Duque-Magalhaes, MC; Packer, L | 1 |
| Bourke, E; Costello, J; Keane, DM | 1 |
| Pitts, RF | 1 |
| Puschett, JB; Steinmuller, ST | 1 |
| Buniatian, HCh; Hovhannissian, VS; Sahagian, JJ | 1 |
| Preuss, HG; Vertuno, LL; Vivatsi-Manos, O | 1 |
| Curthoys, NP; Lowry, OH | 1 |
| Goodman, AD | 1 |
| White, AG | 1 |
| Chappell, JB; Crompton, M | 1 |
| Aoki, TT; Brennan, MF; Cahill, GF; Muller, WA | 1 |
| Berezov, TT; Evseev, LP; Khisamov, GZ; Zanin, VA | 1 |
| Dolowy, WC; Fitzmaurice, MA; Holcenberg, JS; Riley, V; Roberts, J; Spackman, D | 1 |
| Dhiensiri, K; Glasgow, AM | 1 |
| Baird, K; Preuss, HG; Vavatsi-Manos, O; Vertuno, CL | 1 |
| Goodman, D; Kafkewitz, D | 1 |
| Balis, ME; Miller, HK | 1 |
| Dolowy, WC; Holcenberg, JS; Roberts, J | 2 |
| Milner, L; Prusiner, S | 1 |
| Hayashida, H; Kikuchi, M; Nakano, E; Sakaguchi, K | 1 |
| Lemieux, G; Robitaille, P; Vinay, P | 1 |
| Gross, R; Hirschmann, WD; Oerkermann, H | 1 |
| Fitzmaurice, MA; Riley, V; Spackman, DH | 1 |
| Brown, CM; Meers, JL; Tempest, DW | 1 |
| Fhaolain, IN; O'Donovan, DJ | 1 |
| Belser, WL; Hutchinson, MA; Robb, F | 1 |
| Balagura-Baruch, S; Welbourne, TC | 1 |
| Preuss, HG | 1 |
| Kamm, DE; Strope, GL | 1 |
| Kodama, I | 1 |
| Blackburn, EH; Hird, FJ | 1 |
| Blackburn, EH; Hird, FJ; Jones, IK | 1 |
| Bourke, E; Fine, A; Scott, J | 2 |
| Greenberg, RE; Irias, JJ | 1 |
| Guilbault, GG; Shu, FR | 1 |
| McDermott, M; O'Donovan, DJ | 1 |
| Kagan, HM; Manning, LR; Meister, A | 1 |
| Polishchuk, SN; Silakova, AI | 1 |
| Sergeeva, SA | 1 |
| Banerjee, SK; Choudhuri, L; Shrivastava, GC | 1 |
| Asher, RR; Kamm, DE | 1 |
| Damian, AC; Pitts, RF | 1 |
| Beyermann, K; Weise, K | 1 |
| Auricchio, S | 1 |
| Katunuma, N; Kuroda, Y; Matsuda, Y | 1 |
| Dudchik, GKh | 1 |
| Maruyama, M; Sato, Y; Uchida, Y | 1 |
| Chappell, JB; Kovacević, Z; McGivan, JD | 1 |
| Bourke, E; Frindt, G; Rubio-Paez, D; Schreiner, GE | 1 |
| Jagenburg, R; Lindstedt, G; Malmquist, J | 1 |
| Klahr, S | 1 |
| Christophe, J; Hebbelinck, M; Kutzner, R; Winand, J | 1 |
| Tower, DB; Wherrett, JR | 1 |
| Svenneby, G | 1 |
| Andreeva, TV; Promyslov, MSh | 1 |
| Hermann, H; Kluge, H; Wieczorek, V | 1 |
| Hammer, RA; Hartman, SC | 1 |
| Hartman, SC | 1 |
| Bignall, MC; Elebute, O; Lotspeich, WD | 1 |
| Katsunuma, T; Katunuma, N; Temma, M | 1 |
| Pincus, JH; Waelsch, H | 1 |
| Lotspeich, WD; O'Donovan, DJ | 1 |
| Cavallo, F; Coghe, M; Grillo, MA | 1 |
| Aprison, MH; Graham, LT | 1 |
| Folk, JE; Toda, H | 1 |
| Sherrard, DJ; Simpson, DP | 1 |
| Charles, R; De Haan, EJ; Hoek, JB; Tager, JM | 1 |
| Banerjee, SK; Majumdar, A; Shrivastava, GC | 1 |
| Weil-Malherbe, H | 1 |
| DeBruin, H; Mattenheimer, H | 1 |
| Huang, L; Liao, D; Shao, G | 1 |
| Ottaway, JH; Sowerby, JM | 1 |
| Bekir-zade, GM; Silakova, AI | 1 |
| Bayer, SM; McMurray, WC | 1 |
| Guder, WG; Ross, BD | 1 |
| Dass, PD; Welbourne, TC | 1 |
| Lund, P | 2 |
| Kvamme, E; Lenda, K | 1 |
| Acquarone, N; Deferrari, G; Garibotto, G; Ghiggeri, GM; Robaudo, C; Sala, R | 1 |
| Bruzzone, M; Deferrari, G; Garibotto, G; Ghiggeri, GM; Robaudo, C | 1 |
| Nissim, I; Segal, S; Yudkoff, M | 1 |
| Alleyne, GA; Barnswell, J; Benjamin, J; Hortelano, P; Lupianez, JA; McFarlane-Anderson, N; Scott, B | 1 |
| Hecker, J; Simpson, D | 1 |
| Alleyne, GA; Anderson, NM; Hortelano, P | 1 |
| Kovacevic, Z; McGivan, JD | 1 |
| Biltz, RM; Letteri, JM; Palekar, A; Pellegrino, ED; Pinkus, LM | 1 |
| Curthoys, NP | 2 |
| Colpoys, MF; Kapadia, CR; Muhlbacher, F; Smith, RJ; Wilmore, DW | 1 |
| Durschlag, RP; Larson, S; Smith, RJ; Stred, SE | 1 |
| Agarwal, KN; Prasad, C | 1 |
| Foda, MS; Hashem, SA; Zedan, HH | 1 |
| Baverel, G; Krebs, HA; Lund, P | 1 |
| Balling, R; Coon, C | 1 |
| Bendich, A; Kafkewitz, D | 2 |
| Abuchowski, A; Bendich, A; Davis, FF; Kafkewitz, D | 1 |
| Schoolwerth, AC; Strzelecki, T | 1 |
| Abou-Khalil, S; Abou-Khalil, WH; Yunis, AA | 1 |
| Roeder, LM; Tildon, JT | 1 |
| McGivan, JD; Patel, M | 1 |
| Kvamme, E; Svenneby, G; Torgner, IA | 1 |
| Adam, WR | 1 |
| Windmueller, HG | 1 |
| Bajin, K; Kovacević, Z | 1 |
| Hecker, J; Simpson, DP | 1 |
| Gougoux, A; Guern, C; Lemieux, G; Pichette, C; Vinay, P | 1 |
| Ozand, PT; Zielke, CL; Zielke, HR | 1 |
| Biltz, RM; Letteri, JM; Pellegrino, ED; Pinkus, L | 1 |
| Baverel, G; Durozard, D | 1 |
| Herbert, RA; Macfarlane, GT | 1 |
| Benjamin, AM | 1 |
| Joseph, SK; Lacey, JH; McGivan, JD | 1 |
| Nimmo, GA; Tipton, KF | 1 |
| Bernlohr, RW; Cook, WR; Hoffman, JH | 1 |
| Bradford, NM; Joseph, SK; Lacey, JH; McGivan, JD | 1 |
| Kvamme, E; Olsen, BE | 1 |
| Ozand, PT; Sevdalian, DA; Zielke, HR | 1 |
| Bajin, K; Kovacević, Z; Pavlovic, M | 1 |
| Akerboom, TP; Häussinger, D; Sies, H | 1 |
| Kanamori, K; Kuo, EL; Ross, BD | 1 |
| Cherbuy, C; Darcy-Vrillon, B; Duée, PH; Morel, MT; Pégorier, JP | 1 |
| Abcouwer, S; Abouhamze, A; Chakrabarti, R; Copeland, EM; Sarantos, P; Souba, WW | 1 |
| Brosnan, JT; Ewart, HS; Squires, SA | 1 |
| Grossfeld, RM; Hargittai, PT; Lieberman, EM; McKinnon, E | 1 |
| Mu, X; Welbourne, TC | 1 |
| Brosnan, JT; Ewart, HS; Qian, D | 1 |
| Lin, ZP; Nissim, I; States, B; Yudkoff, M | 1 |
| Chedid, A; DeJoseph, MR; Hawkins, RA; Jessy, J; Mans, AM | 1 |
| Curi, R; Rosa, LF; Safi, DA | 1 |
| Biselli, M; Eberhardt, R; Gaetgens, J; Spohn, U; Tramper, J; van der Pol, JJ; Wandrey, C | 1 |
| Kanamori, K; Ross, BD | 1 |
| Bruni, P; Farnararo, M; Meacci, E; Vasta, V | 1 |
| Brosnan, JT; Brosnan, ME; Collett, V; Day, SH; Kovacevic, Z | 1 |
| Dumaswala, UJ; Greenwalt, TJ; Rugg, N | 1 |
| Rennie, MJ; Tadros, LB; Taylor, PM; Willhoft, NM | 1 |
| Carlson, L; Godfrey, DA; Parli, JA; Ross, CD | 1 |
| deBoer, PA; Lamers, WH; Moorman, AF; Schoolwerth, AC | 1 |
| Daikhin, Y; Nissim, I; Pleasure, D; Stern, J; Yudkoff, M | 1 |
| Bode, BP; Souba, WW | 1 |
| Brosnan, JT; Brosnan, ME; Day, SH; Ewart, HS; Kovacevic, Z; Squires, SA | 1 |
| deBoer, P; Lamers, WH; Moorman, AF; Schoolwerth, AC | 1 |
| Kilberg, MS; Nam, M; Tamarappoo, BK; Welbourne, TC | 1 |
| Jackson, MJ; Max, SR; Tildon, JT; Zielke, HR | 1 |
| Flynn, NE; Knabe, DA; Wu, G | 1 |
| Ahmed, N; Weidemann, MJ; Williams, JF | 1 |
| Brosnan, JT; Ewart, HS | 1 |
| Chakrabarti, R; Copeland, EM; Dudrick, PS; Ockert, K; Sarantos, P; Souba, WW | 1 |
| Curi, R; Guimaraes, AR; Rosa, LF; Safi, DA; Williams, JF | 1 |
| Bereznowski, Z; Makarewicz, W; Swierczyński, J | 1 |
| Curi, R; De Almeida, AF; Rosa, LF; Safi, DA | 1 |
| Curthoys, NP; Watford, M | 1 |
| Calderón, J; Du Pont, G; Durán, S; Huerta-Zepeda, A | 1 |
| Boehlein, SK; O'Leary, MH; Richards, NG; Schuster, SM; Stoker, PW | 1 |
| Costa Rosa, LF; Curi, R; Romaldini, JH; Werner, MC | 1 |
| Kannan, Y; Kimura, K; Makiyama, I; Moriyama, M; Ohta, M; Shiota, M; Sugano, T; Uesugi, K | 1 |
| Aptekar, L; Fich, A; Goldin, E; Siguencia, J; Tsvang, E; Zimmerman, J | 1 |
| Tildon, JT; Zielke, CL; Zielke, HR | 1 |
| Costa Rosa, LF; Curi, R; Cury, Y; Safi, DA | 1 |
| Koide, S; Lew, JI; Rombeau, JL; Smith, RJ; Zhang, W | 1 |
| Brosnan, JT; Nissim, I; Yudkoff, M | 1 |
| Colomb, V; Corriol, O; Darcy-Vrillon, B; Duée, PH; Guihot, G; Jobert, A; Morel, MT; Ricour, C | 1 |
| Colquhoun, A; Newsholme, EA | 1 |
| Curthoys, N; Giffard, RG; Newcomb, R; Sun, X; Taylor, L | 1 |
| Fischer, JE; Hasselgren, PO; James, JH; Noguchi, Y | 1 |
| Calderón, J; Du Pont, G; Durán, S; Huerta-Saquero, A; Huerta-Zepeda, A; Sánchez-Linares, L | 1 |
| Curi, R; Curi, TC; de Azevedo, RB; de Melo, MP | 1 |
| Hall, JC; Heel, KA; McCauley, RD | 1 |
| Rosa, LF | 1 |
| Bernard, A; Demuyter, P; Erbs, P; Jund, R | 1 |
| Greenman, J; Hassan, IJ; Millar, MR; Stark, RM; Suleiman, MS | 1 |
| Barbieri, DH; Curi, R; dos-Santos, MA; Rosa, R | 1 |
| Chen, K; Haque, SM; Iiboshi, Y; Masunari, A; Nezu, R; Okada, A; Okuyama, H; Takagi, Y; Usui, N | 1 |
| Curi, R; Curi, TC; De Azevedo, RB; De Melo, MP; Zorn, TM | 1 |
| Brosnan, JT; Brosnan, ME; Ewart, HS; McCarthy, C; Squires, SA | 1 |
| Curi, R; De Azevedo, RB; Lacava, ZG; Rosa, LF | 1 |
| Bartol, I; Cipolla-Neto, J; Costa Rosa, LF; Fernandes, LC; Martins, E | 1 |
| Hawkins, RA; Lee, WJ; Peterson, DR; Viña, JR | 1 |
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| Chen, LX; Li, H; Li, XZ; Tang, RT; Wu, CR; Yang, KY; Zheng, MZ | 1 |
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| Cerione, RA; Erickson, JW; Li, Y; Nguyen, TT; Ramachandran, S; Stalnecker, CA | 1 |
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| Adiseshaiah, PP; Burgan, W; Goswami, D; Guerin, TM; Kozlov, SV; McCormick, F; Mukhopadhyay, S; Nissley, DV; Yi, M | 1 |
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| Abbara, A; Babwah, AV; Bech, PR; Bhattacharya, M; Brackstone, M; Clarke, S; Dhillo, WS; Dragan, M; Goertzen, C; Guzman, S; Hess, DA; Nguyen, MU; Pine, SR; Su, X; Tuck, AB; Wondisford, FE; Zong, WX | 1 |
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| Chen, K; Li, J; Lin, L; Liu, C; Qin, Z; Sarath Babu, V; Shi, F; Su, Y; Sun, L; Zhao, L | 1 |
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| Baguley, BC; Dechaume, AL; Katt, WP; Leung, EY; Murray, PM; Singleton, DC | 1 |
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| Campos-Sandoval, JA; de Los Santos-Jiménez, J; Márquez, J; Matés, JM | 1 |
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| Asaka, R; Asaka, S; Attarwala, N; Chen, X; Chen, YW; Chuang, CM; Davidson, B; DeMarzo, AM; Gaillard, S; Hong, J; Hsu, FC; Jung, JG; Le, A; Shen, YA; Shih, IM; Suryo Rahmanto, Y; Tomaszewski, A; Wang, TL; Yen, TT; Zhang, C | 1 |
| Bajor, DL; Chen, Y; Selfridge, JE; Wang, Z; Zhao, Y | 1 |
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| Chang, HW; Han, MW; Kim, MR; Kim, SH; Kim, SW; Kim, SY; Lee, JC; Lee, M; Lee, YS; Nam, HY; Park, JJ | 1 |
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| Abdollahi, A; Alves, TC; Aschenbrenner, B; Baretton, GB; Baumann, M; Behrens, B; Chen, O; Dubrovska, A; Eisenhofer, G; Franken, A; Groeben, C; Hölscher, T; Kahya, U; Krause, M; Kunz-Schughart, LA; Labitzky, V; Lange, T; Linge, A; Löck, S; Lohaus, F; Lukiyanchuk, V; Mirtschink, P; Mukha, A; Negro, G; Neubauer, H; Peitzsch, C; Peitzsch, M; Rehm, M; Richter, S; Rivandi, M; Schwager, C; Skvortsov, S; Skvortsova, II; Sommer, U; Stoecklein, NH; Telychko, V; Toma, M; Zschaeck, S | 1 |
| Atri, P; Batra, SK; Bhatia, R; Cox, JL; Ganguly, K; Kaur, S; Kisling, A; Kumar, S; Mallya, K; Ram Krishn, S; Rauth, S; Shinde, D; Thomas, V; Thompson, C; Vengoji, R | 1 |
| Cederkvist, H; Kolan, SS; Sener, Z; Skålhegg, BS; Wik, JA | 1 |
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| Chen, J; Dang, R; Emberley, E; Gross, M; Huang, T; Li, W; MacKinnon, A; Pan, A; Parlati, F; Singh, D; Sotirovska, N; Steggerda, SM; Wang, T | 1 |
| Cerqueira, NMFSA; Pina, AF; Sousa, SF | 1 |
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| Arenholz, E; Cerione, RA; Finke, A; Huang, Q; Katt, WP; Kriksunov, I; McDermott, LA; Milano, SK; Nguyen, TT; Ramachandran, S; Schuller, DJ; Sukumar, N; Szebenyi, DM | 1 |
| Burczynski, ME; Chen, H; Cheng, X; Halasz, G; Kim, S; Lin, AZ; Mao, X; Murphy, AJ; Na, E; Okamoto, H; Sleeman, MW | 1 |
| Manonmani, HK; Sindhu, R | 1 |
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| Fu, X; Li, K; Li, N; Liang, H; Lin, Q; Liu, L; Luo, X; Niu, Y | 1 |
| Alman, BA; Ban, GI; Ding, X; Karner, CM; Nadesan, P; Puviindran, V; Shen, L; Tang, YJ; Tsushima, H; Yahara, Y; Zhang, GF; Zhang, H | 1 |
| Ge, J; Wang, B; Xu, J; Zhao, S | 1 |
| Qian, CJ; Teng, XS; Tong, YY; Wang, YC; Yao, J | 1 |
| Cao, Y; Chen, X; Han, A; Hu, J; Jiang, B; Li, Q; Lin, D; Lin, F; Liu, M; Liu, Q; Ma, H; Wang, J; Wu, C; Yao, L; Zhang, C; Zhang, J; Zhao, G; Zhao, W; Zheng, Y | 1 |
| Berisaj, M; Cross, J; Eskandari, R; Granlund, KL; Keshari, KR; Kim, N; Mamakhanyan, A; Poot, AJ; Saoi, M; Thompson, CB; Zhang, G | 1 |
| Guo, H; Li, D; Li, W; Liu, N; Pan, G; Sheng, X; Wang, C; Yuan, L | 1 |
| Akella, L; Bendell, J; Emamekhoo, H; Fan, AC; Gartrell, BA; Goodman, OB; Hsieh, JJ; Hussain, A; Kalebasty, AR; Lee, CH; Liu, S; Matrana, M; McCune, S; Motzer, R; Nikolinakos, PG; Orford, K; Parmar, H; Patel, V; Percent, I; Shaheen, M; Tannir, NM; Vaishampayan, U; Zakharia, Y; Zhang, Z | 1 |
| Andreani, S; Bacci, M; Cappello, P; Corbo, V; Costamagna, A; De Santis, MC; Delfino, P; Di Gregorio, E; Giovannetti, E; Gozzelino, L; Gulluni, F; Hirsch, E; Lattanzio, R; Lorito, N; Margaria, JP; Martini, M; Mina, E; Morandi, A; Novelli, F; Porporato, PE; Ratto, E; Sala, G; Scarpa, A; Vicentini, C | 1 |
| Bearne, SL; Guo, CJ; Liu, JL | 1 |
| Alam, K; Bastani, NE; Chowdhury, A; Grimolizzi, F; Kolan, S; Li, G; Skålhegg, BS; Wik, JA | 1 |
| Cao, J; Choi, H; Gupta, M; Lee, HS; Mankoff, D; Pantel, A; Zhou, R | 1 |
| Cheng, C; Jiang, X; Li, B; Li, H; Li, Y; Liu, Q; Meng, G; Qian, L; Sun, B; Wang, Y; Xie, Y; Xu, T; Xu, Y; Yu, D; Zhang, L | 1 |
| Hosokawa, H; Kanda, H; Lee, E; Miki, T; Nakayama, A; Prives, C; Stockwell, BR; Suzuki, S; Tanaka, T; Venkatesh, D; Yokote, K | 1 |
| Almeida, MR; Bento, HBS; Carvalho, PJ; Paiva, GB; Pedrolli, DB; Santos-Ebinuma, VC; Silva, CG; Tavares, APM | 1 |
| Chang, JS; Chen, HA; Chiu, CF; Hsu, TW; Lin, CY; Park, JM; Peng, JM; Saengboonmee, C; Shan, YS; Shen, YS; Su, YH | 1 |
| Ferreira, FV; Martínez, YB; Musumeci, MA | 1 |
| Chang, HY; Hsia, SM; Hsu, KC; Huang, TC; Lin, JR; Lin, LC; Lin, TE | 1 |
| Chae, CH; Cho, BC; Choi, G; Cyriac, R; Duggirala, KB; Jang, J; Jung, ME; Lee, EJ; Lee, K; Lee, Y; Yun, MR | 1 |
| Agarwal, N; Akella, L; Appleman, LJ; Davis, N; Escudier, B; Figlin, R; Gandhi, S; Geynisman, DM; Goodman, O; Iacovelli, R; Jain, RK; Lawrence, NJ; Lee, RJ; McGregor, B; Mellado, B; Motzer, R; Orford, K; Porta, C; Powles, T; Sepúlveda Sánchez, JM; Stadler, WM; Tannir, NM | 1 |
| Guo, XY; Guo, Y; Li, HJ; Lu, L; Lu, N; Zhang, M | 1 |
| Hu, Y; Jiang, S; Su, W; Xu, Y; Zhang, Q | 1 |
| Feng, Y; Huang, W; Li, C; Li, X; Shang, L; Wang, W; Wang, X; Wu, X; Xu, L; Yao, Y; Ying, P; Zhang, M; Zhang, Q | 1 |
| Baker, R; Bazzaro, M; Clemente, V; Erickson, BK; Hoshino, A; Khalifa, M; Lou, E; Nelson, A; Rubin, N; Shetty, M; Weroha, SJ | 1 |
| Bi, Y; Jiang, Z; Wang, G; Wang, X; Zhang, X | 1 |
| Chen, L; Liu, X; Wang, T | 1 |
| Cui, X; Huang, S; Jiang, C; Li, W; Lin, R; Liu, K; Liu, Y; Ma, J; Miao, H; Qiu, S; Wang, Z; Wu, W; Zhang, Y; Zou, L | 1 |
| Ji, G; Luo, B; Shen, G; Tian, T | 1 |
| Jiang, H; Li, J; Tu, H; Wen, J; Wu, W; Yin, X; Zhai, B | 1 |
| Brantley-Sieders, DM; Chen, J; Edwards, DN; Hwang, Y; Karno, B; Ngwa, VM; Richmond, A; Wang, X; Yan, C | 1 |
| Cai, Q; Che, Y; Chen, Z; Jiang, VC; Jordan, A; Leeming, A; Li, L; Li, Y; Liu, Y; Nie, L; Vargas, J; Wang, M; Wang, W; Yao, Y | 1 |
| Cheng, B; Hu, J; Li, W; Ling, Z; Lu, J; Su, Z; Tao, X; Zeng, Q | 1 |
| Chuang, YC; Kao, TW; Kuo, CC; Lee, HL; Shen, YA | 1 |
| Ahumada, K; Boroughs, LK; Brugarolas, J; Cai, F; Chiang, JC; DeBerardinis, RJ; Do, QN; Faubert, B; Genovese, G; Kapur, P; Kaushik, AK; Li, X; Mathews, TP; Merritt, M; Pachnis, P; Ragavan, M; Rao, AD; Rosales, T; Saatchi, F; Slusher, BS; Stevens, C; Sun, X; Tarangelo, A; Tcheuyap, VT; Vu, H; Wu, CY; Yong, C; Zacharias, LG; Zhang, Y | 1 |
| Bian, J; Chang, X; Li, Z; Wang, J; Wang, M; Xu, X; Zhang, D; Zhang, Y | 1 |
| Datta, KK; Gowda, H; He, Y; Hooper, JD; Kalimutho, M; Khanna, KK; Lu, X; Maheshwari, UR; Mayoh, C; Raninga, PV; Venkat, P | 1 |
| Bian, J; Chen, R; Gong, G; Guo, Z; Huang, H; Li, X; Li, Z; Lu, Y; Wang, D | 1 |
| Bae, SW; Cohen, AS; Geng, L; Georgiou, DK; Manning, HC; Tantawy, MN; Wang, J; Wen, X | 1 |
| Aguera, K; Andrivon, A; Blachier, J; Châlons-Cottavoz, M; Cleret, A; Fanjat, JM; Gallix, F; Gay, F; Gil, C; Guerin, N; Horand, F; Laperrousaz, B; Piedrahita, D; Rama, N; Rossignol, R; Tavernier, F; Vidault, L | 1 |
| Gouda, H; Jo, M; Kanayama, D; Koizumi, K; Mizuguchi, M; Mori, H; Nabeshima, Y; Obita, T; Okada, T; Suzuki, M; Toyooka, N; Watanabe, Y | 1 |
| Chen, L; Guo, M; Li, M; Ma, J; Niu, P; Wang, H; Wang, J | 1 |
| Durante, W | 1 |
| Kuzuyama, T; Nagata, R; Nishiyama, M | 1 |
| Cai, FP; Chen, H; Chen, JY; Chen, YH; Dong, RN; Ke, ZB; Lin, TT; Wei, Y; Xu, N; Xu, YC; Xue, XY; Zheng, QS | 1 |
| Blatt, EB; Bogdan, D; Buroni, L; Carreira, S; de Bono, JS; DeBerardinis, RJ; Gao, Y; Gilbreath, C; Mani, RS; Neeb, A; Parra, K; Paschalis, A; Raj, GV; Yuan, W | 1 |
| Chen, Z; Hu, J; Huang, L; Wang, Q; Xu, G | 1 |
| Chen, P; Hou, P; Ji, M; Li, X; Liu, J; Liu, Y; Ma, J; Qiang, W; Wang, Y; Xie, J | 1 |
| Chen, Z; Fang, L; Huang, H; Jiang, T; Li, B; Li, Y; Li, Z; Lu, C; Lv, J; Wang, S; Wang, W; Xu, P; Xu, Z | 1 |
| Barbosa, RDN; da Conceição, EM; de Oliveira da Silva, LA; de Oliveira Silva, W; de Oliveira, NT; de Souza-Motta, CM; do Nascimento, SS | 1 |
| Rugo, HS; Vidula, N; Yau, C | 1 |
66 review(s) available for glutamine and glutaminase
| Article | Year |
|---|---|
Ammonia production and excretion in the mammalian kidney.
Topics: Acid-Base Equilibrium; Ammonia; Amphibians; Animals; Biological Transport; Cricetinae; Dogs; Glutaminase; Glutamine; Humans; Hydrogen-Ion Concentration; Kidney; Kidney Tubules, Distal; Kidney Tubules, Proximal; Rats | 1976 |
Ammonia metabolism.
Topics: Ammonia; Animals; Cytosol; Gluconeogenesis; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Homeostasis; Humans; Hydrogen-Ion Concentration; Kidney; Mitochondria; Phosphates | 1978 |
Recent advances in renal tubular biochemistry.
Topics: Acidosis; Adenosine Triphosphatases; Adenosine Triphosphate; Adenylyl Cyclases; Ammonia; Animals; Biological Transport; Cell Membrane; Citric Acid Cycle; Fatty Acids; Gluconeogenesis; Glucose; Glutamates; Glutaminase; Glutamine; Glycolysis; In Vitro Techniques; Kidney Cortex; Kidney Medulla; Kidney Tubules; Kidney Tubules, Proximal; Lactates; Natriuresis; Oxygen Consumption; Sodium | 1976 |
Function of glutathione in kidney via the gamma-glutamyl cycle.
Topics: Acyltransferases; Adult; Amino Acids; Animals; Cysteine; Dipeptidases; gamma-Glutamylcyclotransferase; gamma-Glutamyltransferase; Glutamates; Glutaminase; Glutamine; Glutathione; Glycine; Humans; Kidney; Male; Metabolism, Inborn Errors; Peptide Synthases; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid; Transaminases | 1975 |
The glutamine transaminase-omega-amidase pathway.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Glutaminase; Glutamine; Kidney; Kinetics; Liver; Molecular Weight; Organ Specificity; Rats; Structure-Activity Relationship | 1977 |
Regulation of renal glutamine deamination.
Topics: Acidosis; Ammonia; Animals; Biological Transport; Chronic Disease; Dactinomycin; Deamination; Diazooxonorleucine; Enzyme Inhibitors; Glutamate Synthase; Glutaminase; Glutamine; Humans; Kidney; Mitochondria; Phosphates | 1975 |
Roles of glutamine and glutathione in terminal amino-nitrogen metabolism.
Topics: Allosteric Regulation; Animals; Cystatins; gamma-Glutamyltransferase; Glutaminase; Glutamine; Glutathione; Humans; Nitrogen; Proteins | 1991 |
Glutamine metabolism in the liver: overview and current concepts.
Topics: Ammonia; Animals; Biological Transport; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Humans; Liver | 1989 |
Localization and function of glutamine synthetase and glutaminase.
Topics: Ammonia; Animals; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Humans; Kinetics; Phosphates | 1987 |
Hepatic glutamine metabolism.
Topics: Ammonia; Animals; Biological Transport; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Liver; Models, Biological | 1987 |
Glutamine metabolism in lymphocytes: its biochemical, physiological and clinical importance.
Topics: Amino Acids; Animals; Glutaminase; Glutamine; Intestine, Small; Ketoglutarate Dehydrogenase Complex; Kinetics; Lymphocyte Activation; Lymphocytes; Models, Biological; Muscles; Phosphoenolpyruvate Carboxykinase (GTP); Pyruvates; Pyruvic Acid; Rats | 1985 |
[Mechanisms of ammonia formation in the brain].
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Amino Acid Oxidoreductases; Amino Acids; Ammonia; Animals; Aspartic Acid; Brain; Brain Chemistry; Deamination; Dogs; Flavin-Adenine Dinucleotide; Fumarates; Glutamate Dehydrogenase; Glutaminase; Glutamine; Guanosine Triphosphate; Inosine Nucleotides; Mitochondria; Monoamine Oxidase; NAD; NADP; Nerve Tissue Proteins; Niacinamide; Oxidation-Reduction; Oxygen Consumption; Rats | 1973 |
Kidney.
Topics: Acidosis; Ammonia; Animals; Biological Transport, Active; Blood Pressure; Blood Volume; Chlorides; Cyclic AMP; Diuresis; Extracellular Space; Glomerular Filtration Rate; Gluconeogenesis; Glutaminase; Glutamine; Hormones; Hydrostatic Pressure; Kidney; Kidney Glomerulus; Kidney Tubules, Proximal; Models, Biological; Osmotic Pressure; Sodium; Sympathetic Nervous System; Water-Electrolyte Balance | 1971 |
Glutamine antagonists in chemotherapy.
Topics: Adult; Aminobutyrates; Animals; Asparaginase; Azaserine; Azo Compounds; Child; Diazooxonorleucine; Drug Combinations; Drug Interactions; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Humans; Hydroxylysine; Leukemia; Leukemia L1210; Liver; Methionine Sulfoximine; Mice; Neoplasms; Rats; RNA, Transfer | 1970 |
[Regulation of synthesis of uric acid as the final stage of nitrogen metabolism].
Topics: Animals; Chickens; Glutamate-Ammonia Ligase; Glutamates; Glutaminase; Glutamine; Glycine; Humans; Hypoxanthines; Inosine; Inosine Nucleotides; Liver; Nitrogen; Nucleotidases; Phosphorylase Kinase; Rats; Serine; Uremia; Uric Acid; Xanthine Oxidase; Xanthines | 1972 |
Enzyme distribution along the nephron.
Topics: Animals; Choline; Cyclic AMP; Fructose; Gluconeogenesis; Glutaminase; Glutamine; Glutathione; Glycerol; Glycolysis; Humans; Lipid Metabolism; Lysosomes; Microbodies; Microvilli; Mitochondria; Nephrons; Pentose Phosphate Pathway; Rabbits; Rats; Transaminases; Vitamin D | 1984 |
Glutamine metabolism in the rat.
Topics: Animals; gamma-Glutamyltransferase; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Isoenzymes; Kidney; Liver; Oxygen Consumption; Rats; Transaminases | 1980 |
Glutamine metabolism in metabolic acidosis.
Topics: Acidosis; Acute Disease; Ammonia; Animals; Chronic Disease; gamma-Glutamyltransferase; Glutamate Dehydrogenase; Glutaminase; Glutamine; Intestinal Mucosa; Kidney; Kidney Tubules; Mitochondria; Physical Exertion | 1982 |
Mitochondrial metabolism of glutamine and glutamate and its physiological significance.
Topics: Acidosis; Animals; Aspartate Aminotransferases; Aspartic Acid; Brain; Cells, Cultured; Energy Metabolism; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamates; Glutaminase; Glutamine; Hepatic Encephalopathy; Humans; Intestine, Small; Intracellular Membranes; Kidney; Liver; Mitochondria; Mitochondria, Liver; Muscles; Neoplasms; Organ Specificity; Oxidation-Reduction; Rats | 1983 |
Role of gamma-glutamyltranspeptidase in the renal metabolism of glutathione.
Topics: Ammonia; Animals; gamma-Glutamyltransferase; Glutaminase; Glutamine; Glutathione; Humans; Kidney; Microvilli | 1983 |
Enzyme-induced asparagine and glutamine depletion and immune system function.
Topics: Ammonia; Animals; Asparaginase; Asparagine; Escherichia coli; Glutaminase; Glutamine; Humans; Immunosuppressive Agents; Leukemia; Lymphocytes; Polyethylene Glycols; Vibrio | 1983 |
The inhibition of lymphocyte mitogenesis by asparaginase: a still unexplained phenomenon.
Topics: Animals; Asparaginase; Asparagine; Cell Membrane; Cells, Cultured; Erwinia; Escherichia coli; Glutaminase; Glutamine; Glycoproteins; Humans; Lectins; Lymphocyte Activation; Lymphocytes; Membrane Proteins; Mitosis; Models, Biological; Polyethylene Glycols; Vibrio | 1984 |
Glutamine utilization by the small intestine.
Topics: Acidosis; Animals; Cells, Cultured; Chemical Phenomena; Chemistry; Energy Metabolism; Glutaminase; Glutamine; Intestinal Absorption; Intestine, Small; Kidney; Liver; Phosphates | 1982 |
Hepatic glutaminase expression: relationship to kidney-type glutaminase and to the urea cycle.
Topics: Animals; Cloning, Molecular; Glutaminase; Glutamine; Humans; Kidney; Liver; Urea | 1993 |
Regulation of glutaminase activity and glutamine metabolism.
Topics: Adipose Tissue; Animals; DNA; Gene Expression Regulation, Enzymologic; Glutaminase; Glutamine; Humans; Kidney; Liver; Lung; Mitochondria; Muscle, Skeletal | 1995 |
An overview of mitochondrial glutamine transport and phosphate-activated glutaminase in the kidney.
Topics: Animals; Biological Transport; Carrier Proteins; Enzyme Activation; Glutaminase; Glutamine; Kidney; Mitochondria; Mitochondrial Swelling; Phosphates | 1997 |
Phosphate-activated glutaminase and mitochondrial glutamine transport in the brain.
Topics: Animals; Brain; Glutaminase; Glutamine; Intracellular Membranes; Kidney; Mitochondria; Rats; Swine | 2000 |
Role of mitochondrial glutaminase in rat renal glutamine metabolism.
Topics: Acid-Base Equilibrium; Acidosis; Animals; Cells, Cultured; Glutamate Dehydrogenase; Glutaminase; Glutamine; Ketoglutaric Acids; Kidney Tubules, Proximal; Mitochondria; Models, Chemical; Promoter Regions, Genetic; Rats; RNA, Messenger | 2001 |
Glutamine and cancer.
Topics: Biological Transport; Clinical Trials as Topic; Cloning, Molecular; Dietary Supplements; Gene Expression Regulation, Enzymologic; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Humans; Neoplasms; Nitrogen; Nutritional Status; Transglutaminases; Tumor Cells, Cultured | 2001 |
Glutaminase and the control of airway pH: yet another problem for the asthmatic lung?
Topics: Ammonia; Animals; Anti-Inflammatory Agents; Asthma; Breath Tests; Case-Control Studies; Glutaminase; Glutamine; Humans; Hydrogen-Ion Concentration; Inflammation; Rats; Respiratory Mucosa; Steroids; Up-Regulation | 2002 |
Calorie restriction enhances the expression of key metabolic enzymes associated with protein renewal during aging.
Topics: Aging; Amino Acids; Animals; Carbon; Energy Intake; Energy Metabolism; Enzyme Induction; Food Deprivation; Gluconeogenesis; Glutaminase; Glutamine; Glycogen; Glycolysis; Hepatocytes; Liver; Mice; Models, Biological; Muscle Proteins; Muscle, Skeletal; Nitrogen; Phosphoenolpyruvate Carboxykinase (GTP); Proteins; RNA, Messenger | 2001 |
Neurotransmission in the vestibular endorgans--glutamatergic transmission in the afferent synapses of hair cells.
Topics: Animals; Aspartic Acid; Glutamic Acid; Glutaminase; Glutamine; Hair Cells, Auditory, Inner; Neurons, Afferent; Receptors, Glutamate; Synaptic Transmission | 2001 |
[New concepts in the physiopathology of hepatic encephalopathy and therapeutic prospects].
Topics: Ammonia; Brain; Brain Edema; Dipeptides; Flumazenil; Glutaminase; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia; Inflammation; Intestine, Small; Kidney; Memantine; Models, Molecular; Nerve Tissue Proteins; Nitric Oxide | 2004 |
The new functions of the gut in the control of glucose homeostasis.
Topics: Animals; Gastrointestinal Tract; Gene Expression Regulation, Enzymologic; Gluconeogenesis; Glucose; Glucose-6-Phosphatase; Glutaminase; Glutamine; Homeostasis; Humans; Intestine, Small | 2005 |
Renal response to metabolic acidosis: role of mRNA stabilization.
Topics: Acidosis; Gene Expression Regulation, Enzymologic; Glutaminase; Glutamine; Humans; Hydrogen-Ion Concentration; Kidney; Response Elements; RNA Stability; RNA-Binding Proteins; RNA, Messenger | 2008 |
Gut ammonia production and its modulation.
Topics: Ammonia; Animals; Genetic Predisposition to Disease; Glutaminase; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia; Intestine, Small; Liver Circulation; Liver Failure, Acute; Mutation | 2009 |
Glutamine homeostasis and mitochondrial dynamics.
Topics: Animals; Brain; Glutaminase; Glutamine; Homeostasis; Humans; Mitochondria; Neoplasms; Oxidation-Reduction; Oxidative Stress | 2009 |
Glutamine as a mediator of ammonia neurotoxicity: A critical appraisal.
Topics: Ammonia; Animals; Astrocytes; Brain; Cyclic GMP; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Hepatic Encephalopathy; Humans; Methionine Sulfoximine; Mitochondria; Nitric Oxide | 2010 |
Metabolism and brain cancer.
Topics: Brain Neoplasms; Cell Proliferation; Cell Transformation, Neoplastic; Citric Acid Cycle; Glutaminase; Glutamine; Glycolysis; Humans; Oncogenes; Pentose Phosphate Pathway; Stem Cells | 2011 |
Expanding targets for a metabolic therapy of cancer: L-asparaginase.
Topics: Animals; Antineoplastic Agents; Asparaginase; Asparagine; Drug Delivery Systems; Glutaminase; Glutamine; Humans; Metabolic Networks and Pathways; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2012 |
Glutamine, glucose and other fuels for cancer.
Topics: Ammonia; Animals; Citric Acid Cycle; Glucose; Glutaminase; Glutamine; Glycolysis; Humans; Neoplasms; Oxidative Phosphorylation; Retinoblastoma Protein | 2014 |
Evidence of a vicious cycle in glutamine synthesis and breakdown in pathogenesis of hepatic encephalopathy-therapeutic perspectives.
Topics: Amino Acids, Branched-Chain; Ammonia; Brain; Critical Illness; Drug Interactions; Enterocytes; Glutamic Acid; Glutaminase; Glutamine; Hepatic Encephalopathy; Humans; Hyperammonemia; Intestines; Ketoglutaric Acids; Kidney; Liver; Microbiota; Muscle, Skeletal; Organ Specificity; Phenylbutyrates | 2014 |
Therapeutic strategies impacting cancer cell glutamine metabolism.
Topics: Animals; Antineoplastic Agents; Cell Transformation, Neoplastic; Glutaminase; Glutamine; Humans; Models, Molecular; Molecular Targeted Therapy; Neoplasms; Signal Transduction | 2013 |
Glutaminase regulation in cancer cells: a druggable chain of events.
Topics: Animals; Antineoplastic Agents; Glutaminase; Glutamine; Humans; Neoplasms | 2014 |
Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach.
Topics: Animals; Apoptosis; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Humans; Hypoxia-Inducible Factor 1; Neoplasms; Proto-Oncogene Proteins c-myc; ras Proteins; Tumor Suppressor Protein p53 | 2015 |
[Metabolome analysis of solid tumors].
Topics: 4-Aminobutyrate Transaminase; beta-Alanine; Biomarkers, Tumor; Breast; Breast Neoplasms; Colonic Neoplasms; Female; Gas Chromatography-Mass Spectrometry; Glutamic Acid; Glutaminase; Glutamine; Humans; Metabolome; Neoplasms; Neoplasms, Hormone-Dependent; Ovarian Neoplasms; Ovary | 2016 |
Glutamine Metabolism in Cancer: Understanding the Heterogeneity.
Topics: Glutaminase; Glutamine; Humans; Molecular Targeted Therapy; Neoplasms | 2017 |
Pancreatic Cancer Metabolism: Molecular Mechanisms and Clinical Applications.
Topics: Acrylamides; Adenocarcinoma; Antineoplastic Agents; Citric Acid Cycle; Glutaminase; Glutamine; Humans; Mitochondria; Molecular Targeted Therapy; NAD; NAD(P)H Dehydrogenase (Quinone); Pancreatic Neoplasms; Piperidines | 2018 |
Targeting cancer metabolism through synthetic lethality-based combinatorial treatment strategies.
Topics: Amino Acid Transport System ASC; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase I as Topic; Glucose; Glucose Transport Proteins, Facilitative; Glutaminase; Glutamine; Humans; Lactic Acid; Minor Histocompatibility Antigens; Molecular Targeted Therapy; Monocarboxylic Acid Transporters; Neoplasms; Pyruvate Dehydrogenase Complex | 2018 |
The molecular rationale for therapeutic targeting of glutamine metabolism in pulmonary hypertension.
Topics: Animals; Drug Development; Enzyme Inhibitors; Glutaminase; Glutamine; Humans; Hypertension, Pulmonary; Molecular Targeted Therapy | 2019 |
Non-canonical roles for metabolic enzymes and intermediates in malignant progression and metastasis.
Topics: ATP Citrate (pro-S)-Lyase; Disease Progression; Energy Metabolism; Fatty Acids; Glucose; Glucose-6-Phosphate Isomerase; Glutaminase; Glutamine; Humans; Isocitrate Dehydrogenase; Neoplasm Metastasis; Neoplasms | 2019 |
Therapeutic targeting of glutaminolysis as an essential strategy to combat cancer.
Topics: Antineoplastic Agents; Cell Proliferation; Cellular Reprogramming; Enzyme Inhibitors; Glutaminase; Glutamine; Humans; Neoplasms | 2020 |
Dysregulation of glutaminase and glutamine synthetase in cancer.
Topics: Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Glycolysis; Humans; Neoplasms; Tumor Microenvironment | 2019 |
Glutaminases regulate glutathione and oxidative stress in cancer.
Topics: Animals; Antineoplastic Agents; Antioxidants; Energy Metabolism; Enzyme Inhibitors; Glutamic Acid; Glutaminase; Glutamine; Glutathione; Humans; Mitochondria; Neoplasms; Oxidative Stress; Signal Transduction; Tumor Microenvironment | 2020 |
Glutaminase in microglia: A novel regulator of neuroinflammation.
Topics: Brain; Glutamic Acid; Glutaminase; Glutamine; Humans; Microglia | 2021 |
Inhibition of glutaminolysis in combination with other therapies to improve cancer treatment.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Citric Acid Cycle; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Glutaminase; Glutamine; Glycogen; Humans; Ketoglutaric Acids; Lactic Acid; Signal Transduction | 2021 |
Enhancing the Efficacy of Glutamine Metabolism Inhibitors in Cancer Therapy.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Benzeneacetamides; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Clinical Trials as Topic; Disease Models, Animal; Drug Resistance, Neoplasm; Glutaminase; Glutamine; Humans; Neoplasms; NF-E2-Related Factor 2; Oxidative Stress; Thiadiazoles; Tumor Escape; Tumor Microenvironment | 2021 |
Targeting GLS1 to cancer therapy through glutamine metabolism.
Topics: Apoptosis; Benzophenanthridines; Cell Proliferation; Diazooxonorleucine; Disease Progression; Drug Resistance, Neoplasm; Genes, myc; Glutaminase; Glutamine; Humans; MicroRNAs; Neoplasm Proteins; Neoplasms; NF-kappa B; Oxidation-Reduction; Phosphates; Prognosis; Retinoblastoma Protein; Sulfides; Thiadiazoles | 2021 |
Marine microbial L-glutaminase: from pharmaceutical to food industry.
Topics: Food Industry; Fungi; Glutaminase; Glutamine; Pharmaceutical Preparations; Prospective Studies | 2021 |
Bio-prospecting the future in perspective of amidohydrolase L-glutaminase from marine habitats.
Topics: Amidohydrolases; Bacillus; Ecosystem; Glutaminase; Glutamine; Humans | 2021 |
L-asparaginase-mediated Therapy in L-asparagine Auxotrophic Cancers: A Review.
Topics: Asparaginase; Asparagine; Child; Escherichia coli; Glutaminase; Glutamine; Humans; Leukemia | 2022 |
GTP-Dependent Regulation of CTP Synthase: Evolving Insights into Allosteric Activation and NH
Topics: Adenosine Triphosphate; Allosteric Regulation; Carbon-Nitrogen Ligases; Cryoelectron Microscopy; Cytidine Triphosphate; Glutaminase; Glutamine; Guanosine Triphosphate; Nitric Oxide Synthase; Uridine Triphosphate | 2022 |
L-Glutamine-, peptidyl- and protein-glutaminases: structural features and applications in the food industry.
Topics: Catalysis; Food Industry; Glutamic Acid; Glutaminase; Glutamine | 2022 |
Therapeutic Targeting of Glutaminolysis as a Novel Strategy to Combat Cancer Stem Cells.
Topics: Glucose; Glutamic Acid; Glutaminase; Glutamine; Humans; Neoplasms; Neoplastic Stem Cells | 2022 |
An updated patent review of glutaminase inhibitors (2019-2022).
Topics: Enzyme Inhibitors; Glutaminase; Glutamine; Humans; Neoplasms; Patents as Topic | 2023 |
Glutamine Deficiency Promotes Immune and Endothelial Cell Dysfunction in COVID-19.
Topics: COVID-19; Endothelial Cells; Glutamic Acid; Glutaminase; Glutamine; Humans; Vascular Diseases | 2023 |
2 trial(s) available for glutamine and glutaminase
| Article | Year |
|---|---|
Bacterial glutaminase in treatment of acute leukaemia.
Topics: Acidosis; Adolescent; Adult; Aged; Alcaligenes; Asparagine; Child; Clinical Trials as Topic; Female; Glutaminase; Glutamine; Half-Life; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male | 1976 |
Telaglenastat plus Everolimus in Advanced Renal Cell Carcinoma: A Randomized, Double-Blinded, Placebo-Controlled, Phase II ENTRATA Trial.
Topics: Angiogenesis Inhibitors; Carcinoma, Renal Cell; Everolimus; Glutaminase; Glutamine; Humans; Kidney Neoplasms; Protein Kinase Inhibitors; Sirolimus | 2022 |
786 other study(ies) available for glutamine and glutaminase
| Article | Year |
|---|---|
The properties and large-scale production of L-asparaginase from citrobacter.
Topics: Animals; Asparaginase; Asparagine; Citrobacter; Culture Media; Drug Evaluation, Preclinical; Enterobacteriaceae; Fermentation; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Lymphoma, Non-Hodgkin; Mice; Molecular Weight; Neoplasms, Experimental; Oxygen; Stereoisomerism; Temperature; Zea mays | 1975 |
Effect of para-aminohippurate on renal glutamine metabolism in the rat.
Topics: Aerobiosis; Aminohippuric Acids; Ammonia; Animals; Glutamates; Glutaminase; Glutamine; Hydrogen-Ion Concentration; In Vitro Techniques; Kidney; Lactates; Male; Rats; Urination | 1976 |
Ammonia production by the small intestine of the rat.
Topics: Acidosis; Acute Disease; Ammonia; Animals; Chronic Disease; Duodenum; gamma-Glutamyltransferase; Glutaminase; Glutamine; In Vitro Techniques; Intestine, Small; Jejunum; Organ Specificity; Rats; Starvation | 1976 |
Effect of pH on ammonia production by renal mitochondria.
Topics: Acidosis; Ammonia; Animals; Glutaminase; Glutamine; Hydrogen-Ion Concentration; In Vitro Techniques; Kidney Cortex; Male; Mitochondria; Rats; Rotenone | 1976 |
Triamcinolone activation of renal ammonia production.
Topics: Acidosis; Ammonia; Animals; Enzyme Activation; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Kidney; Male; Mitochondria; Potassium; Rats; Triamcinolone | 1976 |
Kinetics and properties of L-glutaminase and L-asparaginase activities of Pseudomonas ovalis.
Topics: Asparaginase; Asparagine; Enzyme Induction; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Kinetics; Pseudomonas; Streptomycin; Tetracyclines; Time Factors | 1976 |
Submitochondrial localization and function of enzymes of glutamine metabolism in avian liver.
Topics: Animals; Cell Fractionation; Chickens; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Mitochondria, Liver; Transaminases | 1977 |
On the mechanism of glutamine-dependent reductive amination of alpha-ketoglutarate catalyzed by glutamate synthase.
Topics: Ammonia; Apoenzymes; Dithionite; Enterobacter; Enterobacteriaceae; Escherichia coli; Flavins; Glutamate Synthase; Glutamates; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Iron; Ketoglutaric Acids; NADP; Transaminases; Water | 1977 |
[Ammonia formation in the brain during dying and in the recovery period following resuscitation].
Topics: Amides; Ammonia; Animals; Brain; Death; Dogs; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Male; Nerve Tissue Proteins; Resuscitation; Time Factors | 1977 |
Characterization of the glutamine site of Escherichia coli guanosine 5'-monophosphate synthetase.
Topics: Alkylation; Amino Acids; Ammonia; Carbon-Nitrogen Ligases; Diazooxonorleucine; Escherichia coli; Glutaminase; Glutamine; Guanine Nucleotides; Hydrogen-Ion Concentration; Iodoacetamide; Kinetics; Ligases; Pentanoic Acids; Protein Binding | 1977 |
The inhibition by 6-diazo-5-oxo-l-norleucine of glutamine catabolism of the cultured human lymphoblast.
Topics: Azaserine; Azo Compounds; Cell Line; Diazooxonorleucine; gamma-Glutamyltransferase; Glutaminase; Glutamine; Rotenone | 1977 |
Glutamine and ammonia metabolism in the brains of senescent mice.
Topics: Aging; Ammonia; Animals; Brain; gamma-Glutamyltransferase; Glutamates; Glutaminase; Glutamine; Male; Mice | 1978 |
Glutaminase-gamma-glutamyltransferase: subcellular localization and ammonia production in acidosis.
Topics: Acidosis; Ammonia; Animals; Cytosol; gamma-Glutamyltransferase; Glutaminase; Glutamine; Kidney; Male; Methionine Sulfoximine; Mitochondria; Perfusion; Rats; Solubility; Subcellular Fractions | 1978 |
Effects of dietary proteins on fetal brain protein and glutamic acid metabolism in rat.
Topics: Acyltransferases; Amino Acids; Animals; Brain; Dietary Proteins; Female; Fetus; Glutamate Decarboxylase; Glutamate-Ammonia Ligase; Glutamates; Glutaminase; Glutamine; Nerve Tissue Proteins; Organ Size; Phenylacetates; Pregnancy; Rats; Triticum | 1979 |
Influence of aminooxyacetate administration on ammonia-induced metabolic disturbances in the rat liver.
Topics: Acetates; Alanine; Alanine Transaminase; Amino Acids, Dicarboxylic; Aminooxyacetic Acid; Ammonia; Ammonium Chloride; Animals; Aspartate Aminotransferases; Aspartic Acid; Female; Glutaminase; Glutamine; Liver; Rats; Urea | 1976 |
Glutamate and glutamine in the brain of the neonatal rat during hypercapnia.
Topics: Aging; Animals; Animals, Newborn; Body Weight; Brain; Carbon Dioxide; Glutamate-Ammonia Ligase; Glutamates; Glutaminase; Glutamine; Hypercapnia; Organ Size; Rats | 1977 |
[Effect of arginine administration on disturbances of hepatic glutamine metabolism during acute ammonia intoxication in the rat].
Topics: Amino Acids; Ammonia; Animals; Arginine; Female; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Liver; Rats; Transaminases | 1977 |
Regulation of the kidney xanthine dehydrogenase by glutaminase.
Topics: Animals; Cytosol; Glutamates; Glutaminase; Glutamine; Ketone Oxidoreductases; Kidney; Kinetics; Male; Rats; Xanthine Dehydrogenase | 1979 |
Properties of xanthosine 5'-monophosphate-amidotransferase from Escherichia coli.
Topics: Adenosine; Adenosine Triphosphate; Chloromercuribenzoates; Diazooxonorleucine; Diphosphates; Dithionitrobenzoic Acid; Escherichia coli; Glutaminase; Glutamine; Guanine Nucleotides; Kinetics; Ligases; Magnesium; Pyruvates; Sulfhydryl Compounds; Tromethamine | 1977 |
Renal glutaminase in postnatal and adult rats.
Topics: Aging; Animals; Animals, Newborn; Enzyme Activation; Glutamates; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Kidney; Kinetics; Phosphates; Rats | 1975 |
The effects of hyperketonemia on glutamate and glutamine metabolism in developing rat brain.
Topics: Age Factors; Animals; Animals, Newborn; Brain; Dietary Fats; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamates; Glutaminase; Glutamine; Ketoglutaric Acids; Ketone Bodies; Malates; Rats | 1975 |
Regulation of Glutamine Transport in Escherichia coli.
Topics: Ammonia; Asparaginase; Biological Transport, Active; Cell-Free System; Enzyme Repression; Escherichia coli; Glucose; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Glycerol; Quaternary Ammonium Compounds; Salts; Stereoisomerism; Succinates | 1975 |
Regulation of glutaminase levels in Escherichia coli.
Topics: Aerobiosis; Ammonium Chloride; Anaerobiosis; Culture Media; Cyclic AMP; Escherichia coli; Glutamates; Glutaminase; Glutamine; Glycerol; Hydrogen-Ion Concentration; Isoenzymes; Mutation; Temperature | 1975 |
Effects of nephron reduction and dietary protein content on renal ammoniagenesis in the rat.
Topics: Ammonia; Animals; Dietary Proteins; Female; Glutamate Dehydrogenase; Glutamates; Glutaminase; Glutamine; Hydrochloric Acid; Hydrogen-Ion Concentration; Kidney; Kidney Cortex; Nephrectomy; Nephrons; Phosphates; Quaternary Ammonium Compounds; Rats; Urine | 1975 |
A new and specific assay for ammonia and glutamine sensitive to 100 pmol.
Topics: Ammonia; Carbon Radioisotopes; Catalase; Escherichia coli; Glucosephosphate Dehydrogenase; Glutamate Dehydrogenase; Glutaminase; Glutamine; Humans; Isotope Labeling; Salmonella typhimurium | 1978 |
Inactivation of rat renal phosphate-dependent glutaminase with 6-diazo-5-oxo-L-norleucine. Evidence for interaction at the glutamine binding site.
Topics: Animals; Azo Compounds; Binding Sites; Diazooxonorleucine; Glutaminase; Glutamine; Kidney; Kinetics; Phosphates; Protein Binding; Rats | 1979 |
Phosphate activated glutaminase activity and glutamine uptake in primary cultures of astrocytes.
Topics: Aging; Animals; Animals, Newborn; Astrocytes; Biological Transport; Brain; Cells, Cultured; Glutaminase; Glutamine; Kinetics; Mice; Phosphates | 1979 |
Glutamate as a CNS transmitter. II. Regulation of synthesis in the releasable pool.
Topics: Animals; Aspartic Acid; Calcium; Glutamates; Glutaminase; Glutamine; Hippocampus; Kinetics; Male; Potassium; Rabbits | 1979 |
Biologic and antineoplastic effects of enzyme-mediated in vivo depletion of L-glutamine, L-tryptophan, and L-histidine.
Topics: Animals; Asparaginase; Enzymes; Female; Glutaminase; Glutamine; Histidine; Histidine Ammonia-Lyase; Indoles; Mice; Mice, Inbred Strains; Mixed Function Oxygenases; Neoplasms, Experimental; Tryptophan | 1979 |
Enhanced effect of an L-glutamine antagonist, L-(alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, by Acinetobacter L-glutaminase-L-asparaginase.
Topics: Acinetobacter; Amino Acids; Animals; Asparaginase; Carcinoma, Ehrlich Tumor; Drug Synergism; Drug Therapy, Combination; Female; Glutaminase; Glutamine; Glycine; Isoxazoles; Lethal Dose 50; Leukemia L1210; Male; Mice; Oxazoles | 1979 |
Treatment of L5178Y tumor-bearing BDF1 mice with a nonimmunogenic L-glutaminase-L-asparaginase.
Topics: Amidohydrolases; Animals; Antibody Formation; Asparaginase; Asparagine; Drug Therapy, Combination; Glutaminase; Glutamine; Metabolic Clearance Rate; Mice; Neoplasms, Experimental; Polyethylene Glycols | 1979 |
A role for bicarbonate in the regulation of mammalian glutamine metabolism.
Topics: Animals; Bicarbonates; Female; Glutamate Dehydrogenase; Glutaminase; Glutamine; In Vitro Techniques; Intestine, Small; Kidney Tubules; Leucine; Liver; Rats | 1979 |
Glutaminase activity in rat skeletal muscle mitochondria.
Topics: Ammonia; Animals; Glutamates; Glutaminase; Glutamine; In Vitro Techniques; Mitochondria, Muscle; Muscles; Oxidation-Reduction; Oxygen Consumption; Rats | 1978 |
Determination of the specific radioactivity of 14C-labeled glutamic acid and glutamine.
Topics: Carbon Radioisotopes; Glutamate Decarboxylase; Glutamates; Glutaminase; Glutamine; Methods | 1978 |
Kinetics of uptake and activity in mouse liver of glutaminase coupled to desialated orosomucoid.
Topics: Animals; Asparaginase; Female; Glutamates; Glutaminase; Glutamine; Intestine, Small; Liver; Mice; Orosomucoid; Protein Binding; Pseudomonas; Sialic Acids; Spleen | 1978 |
Double-enzymatic assay for determination of glutamine and glutamic acid in cerebrospinal fluid and plasma.
Topics: Glutamate Dehydrogenase; Glutamates; Glutaminase; Glutamine; Humans | 1978 |
Characterization of the apparent rates of glutamine transport in rat renal mitochondria.
Topics: Acidosis; Animals; Biological Transport; Cell-Free System; Glutaminase; Glutamine; Kidney; Kinetics; Male; Mitochondria; Rats; Temperature | 1978 |
Glutamine--a major substrate for nerve endings.
Topics: Animals; Cerebral Cortex; Female; Glucose; Glutamates; Glutaminase; Glutamine; Kinetics; Oxygen Consumption; Potassium; Rats; Synaptosomes | 1978 |
Renal glutamine metabolism in rats fed high-protein diets.
Topics: Acid-Base Equilibrium; Ammonium Chloride; Animals; Dietary Proteins; Glutaminase; Glutamine; Kidney; Male; Mitochondria; Phosphoenolpyruvate Carboxykinase (GTP); Rats | 1978 |
[Effect of Ca2+ and gamma-aminobutyric acid on glutamate and glutamine oxidation by rat brain synaptosomes].
Topics: Animals; Brain; Calcium; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamate Synthase; Glutamates; Glutaminase; Glutamine; Oxidation-Reduction; Rats; Synaptosomes | 1978 |
Enzymic micro-assay for blood glutamine.
Topics: Adult; Aged; Anesthesia; Animals; Ethyl Ethers; Fasting; Female; Glutaminase; Glutamine; Humans; Male; Methods; Microchemistry; Middle Aged; Pentobarbital; Rats; Reference Values | 1978 |
Glutamine metabolism in the kidney during induction of, and recovery from, metabolic acidosis in the rat.
Topics: Acid-Base Equilibrium; Acidosis; Acids; Ammonia; Animals; Glutaminase; Glutamine; In Vitro Techniques; Kidney; Male; Mitochondria; Oxygen Consumption; Rats | 1978 |
Determination of spinal fluid glutamine with the Du Pont aca.
Topics: Ammonia; Glutamate Dehydrogenase; Glutaminase; Glutamine; Humans; Reagent Kits, Diagnostic | 1978 |
Enhancement of melphalan therapy with glutaminase:asparaginase.
Topics: Acinetobacter; Animals; Asparaginase; Asparagine; Drug Synergism; Glutaminase; Glutamine; Leukemia L1210; Melphalan; Mice; Time Factors | 1978 |
The effects of ammonium chloride and bicarbonate on the activity of glutaminase in isolated liver mitochondria.
Topics: Adenosine Triphosphate; Ammonium Chloride; Animals; Bicarbonates; Energy Metabolism; Female; Glutaminase; Glutamine; In Vitro Techniques; Mitochondria, Liver; Rats | 1978 |
Active subunits of Escherichia coli glutamate synthase.
Topics: Ammonia; Cell-Free System; Escherichia coli; Glutamate Dehydrogenase; Glutamate Synthase; Glutamates; Glutaminase; Glutamine; Transaminases | 1976 |
Comparative studies on glutamate metabolism in synpatic and non-synaptic rat brain mitochondria.
Topics: Animals; Aspartate Aminotransferases; Brain; Glutamate Dehydrogenase; Glutamates; Glutaminase; Glutamine; Kinetics; Male; Mitochondria; Oxygen Consumption; Rats; Synapses | 1977 |
Phosphate-dependent glutaminase of small intestine: localization and role in intestinal glutamine metabolism.
Topics: Acidosis; Alkalosis; Animals; Cecum; Colon; Gastric Mucosa; Glutaminase; Glutamine; Ileum; Intestinal Mucosa; Intestine, Small; Jejunum; Ketones; Kidney; Male; Mitochondria; Organ Specificity; Phosphates; Rats; Species Specificity | 1977 |
Importance of the flux of phosphate across the inner membrane of kidney mitochondria for the activation of glutaminase and the transport of glutamine.
Topics: Animals; Biological Transport, Active; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Enzyme Activation; Glutaminase; Glutamine; Kidney; Kinetics; Membranes; Mersalyl; Mitochondria; Mitochondrial Swelling; Oxygen Consumption; Phosphates; Rats; Sucrose; Thermodynamics | 1976 |
[Concentration of free glutamine and glutaminase activity in the gastric mucosa of patients with precancerous diseases and cancer of the stomach].
Topics: Gastric Mucosa; Gastritis; Glutaminase; Glutamine; Humans; Polyps; Precancerous Conditions; Stomach Neoplasms; Stomach Ulcer | 1976 |
The influence of glutamine, its decomposition products, and glutaminase on the transformation of human and mouse lymphocytes.
Topics: Adult; Ammonia; Animals; B-Lymphocytes; Female; Glutaminase; Glutamine; Humans; Lectins; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Pyrrolidonecarboxylic Acid; T-Lymphocytes; Thymidine | 1976 |
Effect of Acinetobacter glutaminase-asparaginase treatment on free amino acids in mouse tissues.
Topics: Acetyltransferases; Acinetobacter; Amino Acids; Ammonia; Animals; Asparaginase; Asparagine; Aspartic Acid; Body Weight; Brain; Escherichia coli; Female; Glutamates; Glutaminase; Glutamine; Kidney; Mice; Organ Size; Serine; Spleen; Threonine | 1975 |
Glutamine transport in dog kidney mitochondria: a new control mechanism in acidosis.
Topics: Acidosis; Alkalosis; Ammonia; Animals; Biological Transport; Cell Membrane; Deamination; Dogs; Glutamates; Glutaminase; Glutamine; Kidney; Kidney Cortex; Mitochondria; Phosphates | 1975 |
Renal glutaminases: Diamox inhibition of glutamyltransferase.
Topics: Acetazolamide; Acetyltransferases; Ammonia; Animals; Binding, Competitive; Cytoplasm; Glutaminase; Glutamine; In Vitro Techniques; Kidney; Kidney Cortex; Kidney Medulla; Male; Microsomes; Mitochondria; Rats | 1975 |
Biochemical heterogeneity of glutamine metabolism of rat kidney mitochondria separated by rate zonal centrifugation.
Topics: Acidosis; Ammonia; Animals; Cell Fractionation; Centrifugation, Zonal; Ficoll; Glutaminase; Glutamine; Kidney; Mitochondria; Rats; Succinates; Sucrose | 1975 |
Regulation of renal metabolism by changes in acid-base balance.
Topics: Acid-Base Equilibrium; Acidosis; Alkalosis; Ammonia; Animals; Bicarbonates; Dogs; Glutamates; Glutaminase; Glutamine; Kidney; Liver; Mannitol; Mitochondria; Quaternary Ammonium Compounds | 1975 |
The role of chemical equilibria in organ function.
Topics: Alanine; Amino Acids; Ammonia; Animals; Aspartic Acid; Carbamyl Phosphate; Female; Glutamate Dehydrogenase; Glutaminase; Glutamine; Humans; Kidney; Metabolism; Rats; Thermodynamics; Transaminases; Urea | 1975 |
Ammonia formation from glutamine isomers by nonacidotic and acidotic perfused rat kidneys.
Topics: Acidosis, Renal Tubular; Acyltransferases; Ammonia; Animals; Cytoplasm; Glutaminase; Glutamine; In Vitro Techniques; Kidney; Male; Mitochondria; Rats; Stereoisomerism | 1976 |
Ammonium ions abolish excitatory synaptic transmission between cerebellar neurons in primary dissociated tissue culture.
Topics: Action Potentials; Animals; Cerebellum; Culture Techniques; Electrophysiology; Female; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Membrane Potentials; Neurons; Potassium; Pregnancy; Purkinje Cells; Quaternary Ammonium Compounds; Rats; Synapses; Synaptic Transmission; Tetrodotoxin | 1992 |
Relative role of the glutaminase, glutamate dehydrogenase, and AMP-deaminase pathways in hepatic ureagenesis: studies with 15N.
Topics: AMP Deaminase; Animals; Aspartic Acid; Cells, Cultured; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Isotope Labeling; Kinetics; Liver; Male; Nitrogen Isotopes; Rats; Rats, Inbred Strains; Urea | 1992 |
Glutaminase and glutamine synthetase activities in human cirrhotic liver and hepatocellular carcinoma.
Topics: Carcinoma, Hepatocellular; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Humans; Liver; Liver Cirrhosis; Liver Neoplasms; Mitochondria, Liver; Oxygen Consumption | 1992 |
Adaptive regulation in skeletal muscle glutamine metabolism in endotoxin-treated rats.
Topics: Adaptation, Physiological; Animals; Endotoxins; Escherichia coli; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Male; Muscles; Rats; Rats, Inbred Strains; Regional Blood Flow; RNA, Messenger | 1992 |
Monitoring glutamine in mammalian cell cultures using an amperometric biosensor.
Topics: Amino Acid Oxidoreductases; Animals; Biosensing Techniques; Cells, Cultured; Electric Conductivity; Enzyme Stability; Enzymes, Immobilized; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Hybridomas; Hydrogen Peroxide; Hydrogen-Ion Concentration; Reproducibility of Results; Sensitivity and Specificity | 1992 |
Mechanisms of increased hepatic glutamine uptake in the endotoxin-treated rat.
Topics: Animals; Cell Membrane; Endotoxins; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Kinetics; Liver; Male; Rats; Rats, Inbred Strains | 1992 |
Glutamate production in islets of Langerhans: properties of phosphate-activated glutaminase.
Topics: Amino Acids; Animals; Cells, Cultured; Citrates; Enzyme Activation; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Insulin; Islets of Langerhans; Lactates; Malates; Male; Pancreas; Phosphates; Rats; Rats, Wistar | 1992 |
Amino acid metabolism during platelet storage for transfusion.
Topics: Amino Acids; Blood Component Transfusion; Blood Platelets; Blood Preservation; Glutamates; Glutaminase; Glutamine; Humans; Leukocyte Count; Thrombin | 1992 |
Arteriovenous differences for glutamine in the equine gastrointestinal tract.
Topics: Animals; Arteries; Digestive System; Glutaminase; Glutamine; Horses; Intestinal Mucosa; Veins | 1992 |
Effects of insulin, glucocorticoids and thyroid hormones on the activities of key enzymes of glycolysis, glutaminolysis, the pentose-phosphate pathway and the Krebs cycle in rat macrophages.
Topics: Animals; Cells, Cultured; Citrate (si)-Synthase; Citric Acid Cycle; Dexamethasone; Glucocorticoids; Glutaminase; Glutamine; Glycolysis; Hexokinase; Insulin; Macrophages; Male; Pentose Phosphate Pathway; Phagocytosis; Rats; Rats, Wistar; Thyroid Hormones | 1992 |
Glycine, a new regulator of glutamine metabolism in isolated rat-liver cells.
Topics: Ammonia; Ammonium Chloride; Animals; Carbon Dioxide; Dose-Response Relationship, Drug; Glucose; Glutaminase; Glutamine; Glycine; Liver; Male; Mitochondria, Liver; Ornithine; Rats; Rats, Wistar; Urea | 1992 |
Glutamine catabolism by heart muscle. Properties of phosphate-activated glutaminase.
Topics: Animals; Anions; Calcium; Cations, Divalent; Enzyme Activation; Female; Glutaminase; Glutamine; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Mitochondria, Heart; Phosphates; Rats | 1992 |
p-aminobenzoate synthesis in Escherichia coli: kinetic and mechanistic characterization of the amidotransferase PabA.
Topics: 4-Aminobenzoic Acid; Amino Acid Sequence; Bacterial Proteins; Carbon-Carbon Lyases; Carbon-Nitrogen Ligases; Chorismic Acid; Enzyme Stability; Escherichia coli; Escherichia coli Proteins; Glutaminase; Glutamine; Kinetics; Molecular Sequence Data; Molecular Weight; Transaminases | 1992 |
Endotoxin and renal glutamine metabolism.
Topics: Ammonia; Animals; Blood Urea Nitrogen; Creatinine; Endotoxins; Escherichia coli; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Kidney; Lipopolysaccharides; Male; Oxygen Consumption; Rats; Rats, Inbred Strains; Renal Circulation | 1991 |
Glutamine metabolism in skeletal muscle of septic rats.
Topics: Alanine; Amino Acids; Animals; Constriction; Freezing; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Hindlimb; Infections; Male; Muscle Proteins; Muscles; Osmolar Concentration; Rats; Rats, Inbred Strains; Regional Blood Flow; Tyrosine | 1991 |
Glutamine metabolism in a holostean (Amia calva) and teleost fish (Salvelinus namaycush).
Topics: Amino Acids; Aminooxyacetic Acid; Animals; Aspartic Acid; Fishes; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Mitochondria; Muscles; Oxidation-Reduction | 1991 |
Effects of L-glutamine, glutaminase and glutamine synthetase on CAP threshold of cochlear nerve of guinea pig.
Topics: Animals; Auditory Threshold; Cochlea; Cochlear Microphonic Potentials; Electric Stimulation; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Guinea Pigs; Round Window, Ear | 1991 |
Effects of corticosteroid on the transport and metabolism of glutamine in rat skeletal muscle.
Topics: Amino Acids; Animals; Biological Transport, Active; Body Weight; Dexamethasone; Female; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Muscles; Perfusion; Rats; Rats, Inbred Strains; Regional Blood Flow; Sarcolemma; Sodium | 1991 |
Mechanistic studies on Azospirillum brasilense glutamate synthase.
Topics: Ammonia; Azospirillum brasilense; Glutamate Synthase; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Ketoglutaric Acids; Magnetic Resonance Spectroscopy; NADP; Oxidation-Reduction; Pyridines | 1991 |
Amino acid uptake by liver of genetically obese Zucker rats.
Topics: Alanine; Animals; Biological Transport; Cell Membrane; DNA; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Liver; Obesity; Rats; Rats, Zucker | 1991 |
Effect of cyclocreatine feeding on levels of amino acids in rat hearts before and after an ischemic episode.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Aspartic Acid; Coronary Disease; Creatinine; Diet; Energy Metabolism; Female; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Magnetic Resonance Spectroscopy; Male; Myocardial Reperfusion; Myocardium; Phosphates; Rats; Rats, Inbred Strains | 1991 |
Glutamine and alanine metabolism in lungs of septic rats.
Topics: Alanine; Alanine Transaminase; Animals; Cholesterol; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Ketone Bodies; Lactates; Lung; Male; Peritonitis; Pyruvates; Rats; Rats, Inbred Strains | 1991 |
Regulation of expression of the genes for glutaminase and glutamine synthetase in the acidotic rat.
Topics: Acidosis; Animals; Gene Expression Regulation, Enzymologic; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Male; Rats; Rats, Inbred Strains | 1991 |
Cytokine regulation of intestinal glutamine utilization.
Topics: Animals; Bacterial Infections; Glutaminase; Glutamine; Interleukin-1; Intestinal Mucosa; Male; Rats; Rats, Inbred Strains; Sepsis; Time Factors; Tumor Necrosis Factor-alpha | 1992 |
Metabolic changes of several adipose depots as caused by aging.
Topics: Adipose Tissue; Aging; Animals; Citrate (si)-Synthase; Citric Acid Cycle; Energy Metabolism; Glucosephosphate Dehydrogenase; Glutaminase; Glutamine; Lipid Mobilization; Lipoprotein Lipase; Male; Pentose Phosphate Pathway; Rats | 1991 |
Adaptation of renal tricarboxylic acid cycle metabolism to various acid-base states: study with [3-13C,5-15N]glutamine.
Topics: Acid-Base Imbalance; Acidosis; Adaptation, Physiological; Alkalosis; Ammonia; Animals; Aspartic Acid; Citrate (si)-Synthase; Citric Acid Cycle; Glucose; Glutamate Dehydrogenase; Glutaminase; Glutamine; Ketoglutarate Dehydrogenase Complex; Kidney; Kinetics; Male; Rats; Rats, Inbred Strains | 1991 |
Prevention of radiogenic side effects using glutamine-enriched elemental diets.
Topics: Animals; Enteritis; Food, Fortified; Glutaminase; Glutamine; Intestinal Mucosa; Male; Radiation Injuries, Experimental; Random Allocation; Rats; Rats, Inbred Strains | 1991 |
Adaptive regulation of brush-border amino acid transport in a chronic excluded jejunal limb.
Topics: Alanine; Anastomosis, Roux-en-Y; Asparagine; Biological Transport, Active; Glucose; Glutaminase; Glutamine; Histidine; Jejunum; Kinetics; Microvilli; Sodium | 1991 |
Role of the four conserved histidine residues in the amidotransferase domain of carbamoyl phosphate synthetase.
Topics: Amino Acid Sequence; Base Sequence; Binding Sites; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Escherichia coli; Glutaminase; Glutamine; Histidine; Kinetics; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligonucleotide Probes; Plasmids; Sequence Homology, Nucleic Acid | 1991 |
GABA synthesis in brain slices is dependent on glutamine produced in astrocytes.
Topics: 4-Aminobutyrate Transaminase; Animals; Astrocytes; Brain; Cyclohexanecarboxylic Acids; Diazooxonorleucine; gamma-Aminobutyric Acid; Glutaminase; Glutamine; Kinetics; Methionine Sulfoximine; Rats; Rats, Inbred Strains | 1991 |
Neuronal glutamine utilization: glutamine/glutamate homeostasis in synaptosomes.
Topics: Animals; Calcium; Electrochemistry; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Homeostasis; Hydrogen; Ions; Neurons; Nitrogen Isotopes; Phosphates; Synaptosomes | 1990 |
Regulation of the hydrolytic and transfer activities of gamma-glutamyl transpeptidase.
Topics: Animals; Cattle; Enzyme Activation; gamma-Glutamyltransferase; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Hippurates; Hydrogen-Ion Concentration; Hydrolysis; Kidney; Kinetics; Maleates; Substrate Specificity | 1990 |
Deamidation of glutamine by increased plasma gamma-glutamyltransferase is a source of rapid ammonia formation in blood and plasma specimens.
Topics: Ammonia; Borates; Chromatography, Gel; Diazooxonorleucine; False Positive Reactions; gamma-Glutamyltransferase; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Humans; Maleates; Serine; Specimen Handling | 1990 |
Glutamine metabolism in skeletal muscle of glucocorticoid-treated rats.
Topics: Alanine; Amino Acids; Animals; Culture Techniques; Dexamethasone; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Hindlimb; Male; Muscles; Rats; Rats, Inbred Strains | 1990 |
Impact of methylparathion and malathion on cholinergic and non-cholinergic enzyme systems of penaeid prawn, Metapenaeus monoceros.
Topics: Acetylcholine; Acetylcholinesterase; Ammonia; Animals; Biodegradation, Environmental; Butyrylcholinesterase; Cholinesterases; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Malathion; Methyl Parathion; Nerve Tissue; Penaeidae | 1990 |
Metabolism of glutamine in erythrocytes infected with the human malaria parasite: Plasmodium falciparum.
Topics: Animals; Antimetabolites; Cells, Cultured; Diazooxonorleucine; Erythrocytes; gamma-Glutamyltransferase; Glutaminase; Glutamine; Humans; Isoxazoles; Plasmodium falciparum | 1990 |
Control and function of the transamination pathways of glutamine oxidation in tumour cells.
Topics: Alanine; Animals; Aspartic Acid; Carbon Radioisotopes; Carcinoma, Ehrlich Tumor; Cell Membrane; Citrates; Citric Acid; Cytosol; Glutaminase; Glutamine; Glyoxylates; Kinetics; Liver Neoplasms, Experimental; Mice; Mitochondria, Liver; Rats; Rats, Inbred Strains; Substrate Specificity; Tumor Cells, Cultured; Uranium | 1991 |
Glutamine metabolism in skeletal muscles from the broiler chick (Gallus domesticus) and the laboratory rat (Rattus norvegicus)
Topics: Animals; Chickens; Glutaminase; Glutamine; In Vitro Techniques; Muscles; Oxidation-Reduction; Phosphates; Rats; Species Specificity; Transaminases | 1991 |
Brush border transport of glutamine and other substrates during sepsis and endotoxemia.
Topics: Adult; Animals; Biological Transport; Endotoxins; Escherichia coli Infections; Glutaminase; Glutamine; Humans; Intestine, Small; Kinetics; Male; Microvilli; Rats; Rats, Inbred Strains; Sepsis | 1991 |
Effects of mitochondrial swelling and calcium on phosphate-activated glutaminase in pig renal mitochondria.
Topics: Animals; Biological Transport; Calcium; Glutaminase; Glutamine; Hydrolysis; In Vitro Techniques; Kidney; Mitochondria; Mitochondrial Swelling; Osmotic Pressure; Phosphates; Rats; Swine | 1991 |
Hormonal control of macrophage function and glutamine metabolism.
Topics: Adrenalectomy; Animals; Cell Migration Inhibition; Diabetes Mellitus, Experimental; Epinephrine; Glucocorticoids; Glutaminase; Glutamine; Hormones; Insulin; Macrophages; Male; Metyrapone; Phagocytosis; Rats; Rats, Inbred Strains; Thyroidectomy; Thyroxine; Triiodothyronine | 1991 |
Maximal activity of phosphate-dependent glutaminase and glutamine metabolism in septic rats.
Topics: Alanine; Animals; Arteries; Glutaminase; Glutamine; Intestinal Mucosa; Kidney; Lactates; Lactic Acid; Liver; Lymph Nodes; Lymphocytes; Male; Phosphates; Pyruvates; Pyruvic Acid; Rats; Rats, Inbred Strains; Sepsis; Veins | 1991 |
Evidence indicating that pig renal phosphate-activated glutaminase has a functionally predominant external localization in the inner mitochondrial membrane.
Topics: Alanine; Animals; Ethylmaleimide; Glutaminase; Glutamine; Hydroxybutyrate Dehydrogenase; Intracellular Membranes; Kidney Cortex; Kinetics; Mitochondria; Submitochondrial Particles; Sulfhydryl Reagents; Swine | 1991 |
Effect of the antiepileptic drug sodium valproate on glutamine and glutamate metabolism in isolated human kidney tubules.
Topics: Adult; Ammonia; Glutamate Dehydrogenase; Glutamates; Glutaminase; Glutamine; Humans; In Vitro Techniques; Kidney Cortex; Kidney Tubules; Stimulation, Chemical; Valproic Acid | 1990 |
Response of rat liver glutaminase to pH, ammonium, and citrate. Possible regulatory role of glutaminase in ureagenesis.
Topics: Ammonia; Animals; Citrates; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Male; Mitochondria, Liver; Rats; Rats, Inbred Strains; Urea | 1990 |
Response of rat liver glutaminase to magnesium ion.
Topics: Animals; Freezing; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Kinetics; Magnesium; Male; Mitochondria, Liver; Rats | 1990 |
Intestinal glutamine metabolism after massive small bowel resection.
Topics: Adaptation, Physiological; Alanine; Ammonia; Animals; DNA; Glutaminase; Glutamine; Ileum; Intestine, Small; Jejunum; Organ Size; Proteins; Rats; Rats, Inbred Strains | 1990 |
31P-NMR studies of glucose and glutamine metabolism in cultured mammalian cells.
Topics: Animals; Cell Line; Enzyme Activation; Glucose; Glutaminase; Glutamine; HeLa Cells; Humans; Hybridomas; Magnetic Resonance Spectroscopy; Phosphates | 1990 |
The effects of sepsis and endotoxemia on gut glutamine metabolism.
Topics: Adolescent; Adult; Aged; Animals; Endotoxins; Glutaminase; Glutamine; Humans; Infections; Intestinal Mucosa; Intestines; Male; Middle Aged; Models, Biological; Oxygen; Portal Vein; Rats | 1990 |
Influence of acute metabolic acidosis on the monomer and polymer forms of renal phosphate-dependent glutaminase.
Topics: Acidosis; Acute Disease; Animals; Enzyme Activation; Glutaminase; Glutamine; Kidney Cortex; Kinetics; Male; Mitochondria; Polymers; Rats; Rats, Inbred Strains | 1990 |
Formation and excretion of NH3----NH4+. New aspects of an old problem.
Topics: Acid-Base Equilibrium; Ammonia; Animals; Cell Membrane; gamma-Glutamyltransferase; Glutaminase; Glutamine; Humans; Hydrogen-Ion Concentration; Ion Channels; Kidney Tubules, Proximal; Liver; Loop of Henle; Mitochondria | 1986 |
Maximal activities of glutaminase, citrate synthase, hexokinase, phosphofructokinase and lactate dehydrogenase in skin of rats and mice at different ages.
Topics: Aging; Animals; Burns; Citrate (si)-Synthase; DNA Repair; Glutaminase; Glutamine; Glycolysis; Hexokinase; L-Lactate Dehydrogenase; Lymphocytes; Mice; Phosphofructokinase-1; Purines; Pyrimidines; Rats; Skin; Wound Healing | 1989 |
Simultaneous synthesis and degradation of glutamine in isolated rat liver cells. Effect of vasopressin.
Topics: Animals; Carbon Dioxide; Carbon Radioisotopes; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Kinetics; Liver; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Vasopressins | 1989 |
Stimulation of glutamine metabolism by the antiepileptic drug, sodium valproate, in isolated dog kidney tubules.
Topics: Alanine; Ammonia; Animals; Aspartic Acid; Dogs; Female; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Kidney Tubules; Lactates; Lactic Acid; Male; Pyruvates; Pyruvic Acid; Valproic Acid | 1989 |
Enzymes of glutamine metabolism in inflammation associated with skeletal muscle hypertrophy.
Topics: Animals; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Hypertrophy; Inflammation; Male; Microscopy, Electron; Muscles; Pentose Phosphate Pathway; Rats; Rats, Inbred Strains; Reference Values | 1989 |
Changes in the activity of glutamate related enzymes in cerebral cortex, during insulin-induced seizures.
Topics: Alanine Transaminase; Amino Acids; Animals; Aspartate Aminotransferases; Blood Glucose; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamates; Glutaminase; Glutamine; Insulin; Male; Picrotoxin; Rats; Rats, Inbred Strains; Seizures | 1989 |
Glutamine transport in submitochondrial particles.
Topics: Acidosis; Amino Acids; Animals; Biological Transport; Glutaminase; Glutamine; Kidney; Kidney Cortex; Kinetics; Male; Mitochondria; Radioisotope Dilution Technique; Rats; Rats, Inbred Strains; Rotenone; Submitochondrial Particles; Tritium | 1989 |
Role of glutamine aminotransferase in glutamine catabolism by Saccharomyces cerevisiae under microaerophilic conditions.
Topics: Aerobiosis; Glutaminase; Glutamine; Glyoxylates; Mutation; Pyruvates; Pyruvic Acid; Saccharomyces cerevisiae; Species Specificity; Transaminases | 1989 |
The effect of adenine nucleotides on the rate and fate of glutamine utilization by incubated mitochondria isolated from rat mesenteric lymph nodes.
Topics: Adenine Nucleotides; Animals; Glutaminase; Glutamine; In Vitro Techniques; Ketoglutarate Dehydrogenase Complex; Lymph Nodes; Lymphocytes; Male; Mitochondria; Rats; Rats, Inbred Strains | 1989 |
Functional intracellular glutaminase activity in intact astrocytes.
Topics: Animals; Astrocytes; Glutaminase; Glutamine; Rats | 1989 |
Studies on the mechanism of action of the omeprazole-derived cyclic sulphenamide.
Topics: Adenosine Triphosphatases; Dithioerythritol; Dithiothreitol; Escherichia coli; Free Radicals; Glutaminase; Glutamine; H(+)-K(+)-Exchanging ATPase; Hydrogen-Ion Concentration; Omeprazole; Time Factors | 1988 |
Regulation of glutamine production by skeletal muscle cells in culture.
Topics: Animals; Animals, Newborn; Cells, Cultured; Culture Media; Diazooxonorleucine; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Methionine Sulfoximine; Muscles; Rats; Rats, Inbred Strains | 1985 |
Glutamine metabolism in isolated perfused rat liver. The transamination pathway.
Topics: Alanine; Ammonia; Animals; Carrier Proteins; Cinnamates; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Liver; Male; Methionine; Monocarboxylic Acid Transporters; Perfusion; Phenylpyruvic Acids; Rats; Rats, Inbred Strains; Transaminases; Urea | 1985 |
Functional hepatocyte heterogeneity in ammonia metabolism. The intercellular glutamine cycle.
Topics: Acid-Base Equilibrium; Ammonia; Animals; Bicarbonates; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutaminase; Glutamine; In Vitro Techniques; Liver; Male; Perfusion; Rats; Rats, Inbred Strains; Urea | 1985 |
[13N]Ammonia and L-[amide-13N]glutamine metabolism in glutaminase-sensitive and glutaminase-resistant murine tumors.
Topics: Amino Acids; Ammonia; Animals; Blood Volume; Drug Resistance; Female; gamma-Glutamyltransferase; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; In Vitro Techniques; Liver; Mice; Sarcoma 180; Sarcoma, Experimental; Urea | 1985 |
Monoclonal antibodies specific for bovine pancreatic asparagine synthetase. Production and use in structural studies.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Aspartate-Ammonia Ligase; Aspartic Acid; Binding Sites; Cattle; Chromatography, Affinity; Cross-Linking Reagents; Dimethyl Suberimidate; Glutaminase; Glutamine; Hybridomas; Ligases; Pancreas; Substrate Specificity | 1986 |
Acute and short-term effects of lithium on glutamate metabolism in rat brain.
Topics: 4-Aminobutyrate Transaminase; Alanine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Aspartic Acid; Brain; Brain Stem; Cerebellum; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamates; Glutaminase; Glutamine; Lithium; Rats | 1986 |
Glutamine metabolism in the avian host bearing transplantable hepatomatous growth induced by MC-29 virus.
Topics: Amidophosphoribosyltransferase; Amino Acids; Animals; Chickens; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Liver; Liver Neoplasms, Experimental; Neoplasm Transplantation; Retroviridae; Uric Acid | 1986 |
Regulation of hepatic ammonia metabolism: the intercellular glutamine cycle.
Topics: Ammonia; Animals; Extracellular Space; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Hydrolysis; Liver; Male; Rats; Rats, Inbred Strains; Urea | 1986 |
Regulation of hepatic glutamine metabolism.
Topics: Ammonia; Animals; Biological Transport; Cell Membrane; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Liver; Rats; Urea | 1986 |
Structural-functional organization of hepatic glutamine and ammonium metabolism.
Topics: Ammonia; Animals; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Homeostasis; Liver; Models, Biological; Urea | 1987 |
Contribution by host tissues to circulating glutamine in mice inoculated with Ehrlich ascites tumor cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Kidney; Liver; Mice | 1988 |
Glutamine metabolism in isolated incubated adipocytes of the rat.
Topics: Adipose Tissue; Alanine; Ammonia; Animals; Glucose; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Insulin; Isoproterenol; Lactates; Lactic Acid; Male; Obesity; Rats; Rats, Zucker; Triglycerides | 1988 |
Topographical distribution of neurochemical changes in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acids, Dicarboxylic; Asparagine; Aspartic Acid; Cerebellar Cortex; Cerebral Cortex; Choline O-Acetyltransferase; Glutamates; Glutaminase; Glutamine; Humans; Middle Aged; Somatostatin | 1988 |
Astrocyte metabolism of [15N]glutamine: implications for the glutamine-glutamate cycle.
Topics: Animals; Astrocytes; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Nitrogen Isotopes; Osmolar Concentration | 1988 |
Glutamine as a major nitrogen carrier to the liver in suckling rat pups.
Topics: Amino Acids; Animals; Animals, Suckling; Cell Membrane; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Liver; Nitrogen; Rats; Rats, Inbred Strains; Time Factors | 1988 |
Prominent glutamine oxidation activity in mitochondria of avian transplantable hepatoma induced by MC-29 virus.
Topics: Animals; Avian Leukosis Virus; Chickens; Glutamate Dehydrogenase; Glutaminase; Glutamine; Liver Neoplasms, Experimental; Mitochondria, Liver; Oxygen Consumption; Transaminases | 1986 |
Effects of chronic uraemia on the formation of glucose and urea plus ammonia from L-alanine, L-glutamine and L-serine in isolated rat hepatocytes.
Topics: Acidosis; Alanine; Amino Acids; Ammonia; Animals; Gluconeogenesis; Glutaminase; Glutamine; In Vitro Techniques; L-Serine Dehydratase; Liver; Male; Phlorhizin; Rats; Rats, Inbred Strains; Serine; Urea; Uremia | 1986 |
Effect of diabetic ketosis on jejunal glutaminase.
Topics: 3-Hydroxybutyric Acid; Animals; Diabetes Mellitus, Experimental; Diabetic Ketoacidosis; Fasting; Glutaminase; Glutamine; Hydroxybutyrates; Jejunum; Male; Rats; Rats, Inbred Strains | 1986 |
Self assembly of microtubule associated protein tau into filaments resembling those found in Alzheimer disease.
Topics: Alzheimer Disease; Animals; Glutamates; Glutaminase; Glutamine; Macromolecular Substances; Microtubule-Associated Proteins; Neurofibrils; Peptide Fragments; Polymers; Protein Binding; Swine; tau Proteins | 1986 |
Utilization of glutamine in the developing rat jejunum.
Topics: Animals; Animals, Newborn; Carbon Dioxide; DNA; Glutaminase; Glutamine; In Vitro Techniques; Jejunum; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1988 |
Purification of phosphate-dependent glutaminase from isolated mitochondria of Ehrlich ascites-tumour cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Immunoblotting; Kidney Neoplasms; Kinetics; Mice; Mitochondria; Molecular Weight; Phosphates; Rats | 1988 |
Physiological role of glutaminase activity in Saccharomyces cerevisiae.
Topics: Glutamates; Glutaminase; Glutamine; Mutation; Pyruvates; Pyruvic Acid; Saccharomyces cerevisiae | 1987 |
Evidence of glutamatergic denervation and possible abnormal metabolism in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acids; Brain; Glutaminase; Glutamine; Humans; Phosphates; Time Factors | 1988 |
Maximal activities of glutaminase and some enzymes of glycolysis and ketone body utilization and rates of utilization of glutamine, glucose and ketone bodies by intestinal mucosa after burn injury.
Topics: Animals; Burns; Glucose; Glutaminase; Glutamine; Glycolysis; Intestinal Mucosa; Ketone Bodies; Male; Rats; Rats, Inbred Strains | 1987 |
The regulation of glutamine and ketone-body metabolism in the small intestine of the long-term (40-day) streptozotocin-diabetic rat.
Topics: Animals; Coenzyme A-Transferases; Diabetes Mellitus, Experimental; Glutaminase; Glutamine; In Vitro Techniques; Intestine, Small; Ketone Bodies; Male; Rats; Rats, Inbred Strains; Sulfurtransferases; Time Factors | 1987 |
The maximal activity of phosphate-dependent glutaminase and glutamine metabolism in the colon and the small intestine of streptozotocin-diabetic rats.
Topics: Acidosis; Alkalosis; Animals; Colon; Diabetes Mellitus, Experimental; Glutaminase; Glutamine; Intestinal Mucosa; Intestine, Small; Male; Phosphates; Rats; Rats, Inbred Strains | 1987 |
The maximal activity of phosphate-dependent glutaminase and glutamine metabolism in late-pregnant and peak-lactating rats.
Topics: Animals; Female; Glutaminase; Glutamine; Intestinal Mucosa; Intestine, Small; Kidney; Lactation; Liver; Phosphates; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains | 1987 |
Cell cycle phase perturbations by 6-diazo-5-oxo-L-norleucine and acivicin in normal and neoplastic human cell lines.
Topics: Antimetabolites; Azo Compounds; Cell Cycle; Cell Line; Colonic Neoplasms; Diazooxonorleucine; Drug Evaluation, Preclinical; Glutaminase; Glutamine; Humans; Isoxazoles; Lung Neoplasms; Neoplasms, Experimental; Oxazoles | 1987 |
Maximum activities of some key enzymes of glycolysis, glutaminolysis, Krebs cycle and fatty acid utilization in bovine pulmonary endothelial cells.
Topics: Animals; Catalysis; Cattle; Citric Acid Cycle; Endothelium, Vascular; Energy Metabolism; Fatty Acids; Glutaminase; Glutamine; Glycolysis; Lymphocytes; Nitrogen; Pulmonary Artery; Rats | 1987 |
Hepatic glutaminase flux regulation of glutamine homeostasis. Studies in vivo.
Topics: Acid-Base Equilibrium; Animals; Glutaminase; Glutamine; Homeostasis; Liver; Male; Rats; Rats, Inbred Strains | 1986 |
Influence of reduced concentration of L-glutamine on growth and viability of cells in monolayer, in spheroids, and in experimental tumours.
Topics: Animals; Cell Survival; Cells, Cultured; Fibrosarcoma; Glutaminase; Glutamine; Humans; Lung Neoplasms; Mice; Neoplasms, Experimental; Time Factors; Urinary Bladder Neoplasms | 1986 |
Replacement by site-directed mutagenesis indicates a role for histidine 170 in the glutamine amide transfer function of anthranilate synthase.
Topics: Anthranilate Synthase; Escherichia coli; Genes; Genes, Bacterial; Genotype; Glutaminase; Glutamine; Histidine; Kinetics; Mutation; Oligodeoxyribonucleotides; Plasmids; Serratia marcescens | 1985 |
Renal mitochondrial glutamine metabolism during K+ depletion.
Topics: Ammonia; Animals; Glutaminase; Glutamine; Kidney; Kidney Cortex; Kidney Tubules; Male; Mitochondria; Potassium; Rats | 1986 |
Rat liver glutaminase. Regulation by reversible interaction with the mitochondrial membrane.
Topics: Animals; Chromatography, DEAE-Cellulose; Culture Media; Glutaminase; Glutamine; Intracellular Membranes; Kinetics; Magnesium; Magnesium Chloride; Mitochondria, Liver; Mitochondrial Swelling; Phosphates; Rats | 1985 |
CTP synthetase from Ehrlich ascites tumor cells. Subunit stoichiometry and regulation of activity.
Topics: Adenosine Triphosphate; Animals; Carbon-Nitrogen Ligases; Carcinoma, Ehrlich Tumor; Glutaminase; Glutamine; Kinetics; Ligases; Mice; Nucleotides; Protein Conformation; Substrate Specificity | 1985 |
Phosphate-activated glutaminase in human kidney.
Topics: Ammonia; Calcium; Enzyme Activation; Glutaminase; Glutamine; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Kidney; Molecular Weight; Phosphates; Sulfhydryl Reagents | 1985 |
Effects of solubilization on the kinetics of rat kidney mitochondrial glutaminase.
Topics: Ammonia; Animals; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Kidney; Kinetics; Mitochondria; Phosphates; Rats; Solubility | 1985 |
Intranephron heterogeneity of ammoniagenesis and gluconeogenesis in rats.
Topics: Acidosis; Ammonia; Animals; Gluconeogenesis; Glutaminase; Glutamine; Male; Nephrons; Rats; Rats, Inbred Strains | 1985 |
Enzymes involved in the metabolism of glutamine in certain regions of the brain of paradoxical sleep-deprived rats.
Topics: Ammonia; Animals; Brain; Brain Stem; Cerebellum; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Male; Microsomes; Mitochondria; Rats; Sleep Deprivation; Sleep, REM; Solubility; Stress, Physiological | 1972 |
[Enzymes of glutamine metabolism in the brain in acute hypoxic hypoxia].
Topics: Acute Disease; Animals; Brain; Brain Chemistry; Disease Models, Animal; Female; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Hypoxia, Brain; Rabbits; Transaminases | 1973 |
Comparative studies on glutamine, serine, and glycine metabolisms in ureotelic and uricotelic animals.
Topics: Ammonia; Animals; Carbon Dioxide; Carbon Isotopes; Chickens; Columbidae; Dietary Proteins; Glucose; Glutamate-Ammonia Ligase; Glutamates; Glutaminase; Glutamine; Glycine; Humans; L-Serine Dehydratase; Liver; Male; Pentosyltransferases; Quail; Rats; Serine; Transferases; Urea; Uric Acid | 1973 |
[Characteristics of nitrogen metabolism in the rat brain under the action of a low frequency impulse electromagnetic field].
Topics: Amides; Aminohydrolases; Ammonia; Animals; Brain; Brain Chemistry; Electromagnetic Phenomena; Electrophoresis, Paper; Glutamate-Ammonia Ligase; Glutamates; Glutaminase; Glutamine; Male; Nitrogen; Proteins; Rats; Time Factors | 1972 |
Renal ammoniagenesis and tissue glutamine, glutamine synthetase, and glutaminase I levels in potassium-deficient rats.
Topics: Ammonia; Animals; Carbon Dioxide; Chlorides; Disease Models, Animal; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Kidney; Liver; Male; Muscles; Organ Size; Potassium; Potassium Deficiency; Rats; Renal Veins; Sodium | 1973 |
Stimulation of the hydrolytic activity and decrease of the transpeptidase activity of gamma-glutamyl transpeptidase by maleate; identity of a rat kidney maleate-stimulated glutaminase and gamma-glutamyl transpeptidase.
Topics: Ammonia; Animals; Biological Transport; Carbon Radioisotopes; Depression, Chemical; gamma-Glutamyltransferase; Glutaminase; Glutamine; Glutathione; Hydrogen-Ion Concentration; Hydrolysis; Hydroxylamines; In Vitro Techniques; Kidney; Maleates; Rats; Stimulation, Chemical | 1974 |
[Modification of the enzymes of hepatic glutamine and glutamate metabolism following ammonium salts administration].
Topics: Alanine Transaminase; Ammonium Chloride; Animals; Aspartate Aminotransferases; Carbonates; Enzyme Activation; Female; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamates; Glutaminase; Glutamine; Liver; Phosphates; Quaternary Ammonium Compounds; Rats | 1974 |
[Glutamin metabolism in reticulocytes].
Topics: Amino Acids; Ammonia; Aspartic Acid; Carbon Isotopes; Chromatography; Glutamates; Glutaminase; Glutamine; Ketoglutaric Acids; Oxaloacetates; Reticulocytes | 1968 |
A histochemical study of some aspects of the metabolism of glutamic acid in the cerebellum of mammals.
Topics: Animals; Aspartate Aminotransferases; Cats; Cerebellum; Cytoplasm; Dendrites; Glutamate Dehydrogenase; Glutamates; Glutaminase; Glutamine; Histocytochemistry; Male; Nerve Endings; Neuroglia; Neurons; Purkinje Cells; Rabbits; Rats | 1974 |
[Effect of glucose and insulin in tissue proteins in experimental myocardial infarct].
Topics: Adenosine Triphosphatases; Animals; Arginase; Aspartate Aminotransferases; Dogs; Glucose; Glutaminase; Glutamine; Heart; Insulin; Kidney; Liver; Muscle Proteins; Myocardial Infarction; Myocardium; Nitrogen; Proteins; Urea | 1969 |
A phosphate activated glutaminase in rat liver different from that in kidney and other tissues.
Topics: Acetates; Animals; Brain; Carcinoma, Hepatocellular; Centrifugation, Density Gradient; Chloromercuribenzoates; Female; Fetus; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Intestine, Small; Isoenzymes; Kidney; Kinetics; Liver; Liver Neoplasms; Liver Regeneration; Male; Mitochondria; Phosphates; Pyruvates; Rats; Vibration | 1968 |
Relation of renal cortical gluconeogenesis, glutamate content, and production of ammonia.
Topics: Acid-Base Equilibrium; Acidosis; Adenine Nucleotides; Alkalosis; Ammonia; Animals; Calcium; Culture Media; Cyclic AMP; Food Deprivation; Gluconeogenesis; Glutamates; Glutaminase; Glutamine; Kidney; Male; Methods; Nucleosides; Potassium Deficiency; Rats; Theophylline | 1970 |
Responsiveness of glutamine-metabolizing enzymes in Morris hepatomas to metabolic modulations.
Topics: Adrenalectomy; Animal Feed; Animals; Animals, Laboratory; Carcinoma, Hepatocellular; Cell Line; Chromosomes; Dactinomycin; Dietary Proteins; Enzyme Activation; Glutaminase; Glutamine; Hydrocortisone; Ligases; Liver Neoplasms; Neoplasm Transplantation; Neoplasms, Experimental; Rats; Thyroxine; Transaminases; Transplantation, Homologous | 1970 |
The anthranilate synthetase-anthranilate-5-phosphorribosylpyrophosphate phosphoribosyltransferase aggregate. On the reaction mechanism of anthranilate synthetase from Salmonella typhimurium.
Topics: Amides; Azo Compounds; Benzoates; Binding Sites; Carbon Isotopes; Cyclohexanecarboxylic Acids; Cysteine; Electrophoresis, Disc; Enzyme Activation; Feedback; Glutaminase; Glutamine; Kinetics; Magnesium; ortho-Aminobenzoates; Pentosephosphates; Phosphoric Acids; Protein Binding; Salmonella typhimurium; Sulfides; Transaminases; Transferases; Tryptophan | 1970 |
Enzymic assays for amoonia and L-glutamine in tissue extracts.
Topics: Ammonia; Animals; Buffers; Glutamate Dehydrogenase; Glutaminase; Glutamine; Glycerol; Ketoglutaric Acids; Liver; Liver Extracts; Male; Methods; NAD; Oxidation-Reduction; Phosphates; Rats; Spectrophotometry | 1971 |
Fluorometric measurement of glutamine and asparagine using enzymic methods.
Topics: Adenine Nucleotides; Animals; Asparaginase; Asparagine; Aspartate Aminotransferases; Cerebral Cortex; Escherichia coli; Fluorometry; Glutamate Dehydrogenase; Glutaminase; Glutamine; Hydrolysis; Ketoglutaric Acids; Malate Dehydrogenase; Methods; NAD; Rats | 1971 |
Reversible dissociation of the monomer of glutamine-dependent carbamyl phosphate synthetase into catalytically active heavy and light subunits.
Topics: Adenosine Triphosphatases; Allosteric Regulation; Amino Acids; Ammonia; Binding Sites; Carbamates; Carbon Radioisotopes; Catalysis; Chromatography, Gel; Enzyme Activation; Escherichia coli; Glutaminase; Glutamine; Macromolecular Substances; Nucleotides; Ornithine; Phosphotransferases; Potassium; Thiocyanates; Ultracentrifugation | 1974 |
Inhibition by dithiothreitol of the utilization of glutamine by carbamyl phosphate synthetase. Evidence for formation of hydrogen peroxide.
Topics: Amino Acids; Anaerobiosis; Binding Sites; Carbamates; Carbon Radioisotopes; Dithiothreitol; Drug Stability; Escherichia coli; Glutaminase; Glutamine; Hydrogen Peroxide; Keto Acids; Macromolecular Substances; Oxidation-Reduction; Phosphotransferases; Sulfhydryl Compounds; Sulfhydryl Reagents; Tritium; Valerates | 1974 |
Glutamate synthase: properties of the reduced nicotinamide adenine dinucleotide-dependent enzyme from Saccharomyces cerevisiae.
Topics: Amino Acid Oxidoreductases; Ammonium Sulfate; Cell-Free System; Chemical Precipitation; Chlorides; Chromatography, DEAE-Cellulose; Chromatography, Gel; Culture Media; Glutamate Dehydrogenase; Glutamates; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Ketoglutaric Acids; Manganese; NAD; Saccharomyces cerevisiae; Spectrophotometry | 1974 |
Glutamate and aspartate transport in rat brain mitochondria.
Topics: Animals; Aspartic Acid; Biological Transport; Brain; Glutamates; Glutaminase; Glutamine; In Vitro Techniques; Kidney; Malates; Mitochondria; Mitochondria, Liver; NAD; Osmosis; Potassium; Quaternary Ammonium Compounds; Rats; Swine; Valinomycin | 1974 |
On the regulation of glutaminase in E. coli: metabolite control.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Ammonium Sulfate; Chemical Precipitation; Escherichia coli; Glutamate-Ammonia Ligase; Glutamates; Glutaminase; Glutamine; Stereoisomerism | 1971 |
Changes in glutamic acid and glutamine metabolism in the rat brain after whole body X-irradiation.
Topics: Ammonia; Animals; Brain; Brain Chemistry; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamates; Glutaminase; Glutamine; Male; Radiation Effects; Rats | 1971 |
Glutamic acid as a precursor to N-terminal pyroglutamic acid in mouse plasmacytoma protein (protein synthesis-initiation-immunoglobulins-pyrrolidone carboxylic acid).
Topics: Amino Acyl-tRNA Synthetases; Animals; Carbon Isotopes; Chromatography, Ion Exchange; Chromatography, Paper; Escherichia coli; Female; Glutamate-Ammonia Ligase; Glutamates; Glutaminase; Glutamine; Hydrolysis; Leucine; Liver; Mice; Mice, Inbred Strains; Neoplasm Proteins; Peptide Chain Initiation, Translational; Plasmacytoma; RNA, Transfer; Tritium | 1972 |
The role of glutamine in the oxidative metabolism of malignant cells.
Topics: Ammonia; Animals; Carbon Dioxide; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Cyanides; Glutamates; Glutaminase; Glutamine; Hydrazones; In Vitro Techniques; Ketoglutaric Acids; Kinetics; Liver Neoplasms; Mice; Mitochondria; NADP; Neoplasms, Experimental; Oxygen Consumption; Pyruvates; Rats; Rotenone | 1972 |
The pathway of glutamine and glutamate oxidation in isolated mitochondria from mammalian cells.
Topics: Acetates; Animals; Carbon Dioxide; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Glutamate Dehydrogenase; Glutamates; Glutaminase; Glutamine; In Vitro Techniques; Kidney; Mice; Mitochondria; Mitochondria, Liver; NADP; Oxygen Consumption; Permeability; Pyruvates; Rats; Transaminases | 1971 |
Relation of gluconeogenesis to ammonia production in the kidney.
Topics: Alanine; Ammonia; Ammonium Chloride; Animals; Dogs; Gluconeogenesis; Glucose; Glutamate-Ammonia Ligase; Glutamates; Glutaminase; Glutamine; Guinea Pigs; Hydroxylysine; Ketoglutaric Acids; Kidney; Kinetics; Rabbits; Rats; Species Specificity | 1972 |
A glutamate-dependent phenotype in E. coli K12: the result of two mutations.
Topics: Coliphages; Escherichia coli; Genetic Linkage; Genetics, Microbial; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamates; Glutaminase; Glutamine; Ketoglutaric Acids; Mutation; Phenotype; Transaminases; Transduction, Genetic | 1972 |
Adenosine 3':5'-cyclic monophosphate control of the enzymes of glutamine metabolism in Escherichia coli.
Topics: Adenylyl Cyclases; Bacterial Proteins; Carbon Isotopes; Chloramphenicol; Chromatography, Ion Exchange; Culture Media; Cyclic AMP; Enzyme Activation; Escherichia coli; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Ketoglutaric Acids; Mutation; Osmolar Concentration; Receptors, Drug; Structure-Activity Relationship; Transaminases | 1972 |
[Glutaminase activity in rabbit reticulocytes: determination and behavior during a blood-loss anemia].
Topics: Ammonia; Anemia; Animals; Glutamate Dehydrogenase; Glutamates; Glutaminase; Glutamine; Mitochondria; Oxygen Consumption; Rabbits; Regression Analysis; Reticulocytes; Time Factors | 1974 |
Phosphate-dependent effects of palmityl-CoA and stearyl-CoA on phosphate-activated pig brain and pig kidney glutaminase.
Topics: Animals; Brain; Coenzyme A; Coloring Agents; Enzyme Activation; Glutaminase; Glutamine; Kidney; Kinetics; Ligands; Organ Specificity; Palmitic Acids; Phosphates; Species Specificity; Stearic Acids; Swine | 1974 |
Survey of two types of glutaminases in plasma of patients suffering from cancer & other diseases.
Topics: Adult; Chronic Disease; Female; Glutaminase; Glutamine; Humans; Male; Middle Aged; Neoplasms; Pregnancy; Transaminases | 1974 |
Ratio of glutamine aminotransferase & glutamine aminohydrolase in plasma of patients with malignant & other blood disorders.
Topics: Adult; Bone Marrow; Child; Female; Glutaminase; Glutamine; Hematologic Diseases; Humans; Leukemia; Male; Middle Aged; Transaminases | 1974 |
Role of an allosteric effector. Guanosine triphosphate activation in cytosine triphosphate synthetase.
Topics: Adenosine Triphosphate; Allosteric Regulation; Ammonia; Binding Sites; Carbon Isotopes; Cytosine Nucleotides; Dialysis; Enzyme Activation; Escherichia coli; Filtration; Glutaminase; Glutamine; Guanosine Triphosphate; Kinetics; Ligases; Macromolecular Substances; Mathematics; Models, Chemical; Protein Binding; Protein Conformation; Temperature; Tritium; Uracil Nucleotides | 1972 |
Studies of the mechanism of anthranilate synthase. Evidence for an acyl-enzyme.
Topics: Cyclohexanecarboxylic Acids; Esterases; Glutamates; Glutaminase; Glutamine; Hydrolysis; Hydroxamic Acids; Hydroxylamines; Kinetics; Magnesium; ortho-Aminobenzoates; Quaternary Ammonium Compounds; Salmonella typhimurium; Transaminases; Vinyl Compounds | 1972 |
Control of glutaminase synthesis in Escherichia coli.
Topics: Culture Media; Enzyme Repression; Escherichia coli; Glutaminase; Glutamine; Glycerol; Nitrogen | 1972 |
Interaction of Escherichia coli carbamyl phosphate synthetase with glutamine.
Topics: Adenosine Triphosphate; Amides; Amino Acids; Asparagine; Bicarbonates; Binding Sites; Carbamates; Carbon Isotopes; Chromatography, Gel; Escherichia coli; Glutaminase; Glutamine; Keto Acids; Kinetics; Magnesium; Molecular Weight; Phosphotransferases; Protein Binding; Protein Denaturation; Spectrophotometry, Ultraviolet; Stereoisomerism; Structure-Activity Relationship | 1973 |
Observations on the pH dependence of the glutaminase activity of a glutamine amidotransferase, carbamylphosphate synthetase.
Topics: Catalysis; Dithiothreitol; Enzyme Activation; Escherichia coli; Ethylmaleimide; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Ketones; Kinetics; Phosphotransferases | 1973 |
L-glutamine as a substrate for L-asparaginase from Serratia marcescens.
Topics: Ammonium Sulfate; Animals; Asparaginase; Asparagine; Chemical Precipitation; Chromatography, DEAE-Cellulose; Electrophoresis, Disc; Escherichia coli; Female; Glutaminase; Glutamine; Hot Temperature; Hydrogen-Ion Concentration; Hydrolysis; Mice; Mice, Inbred C3H; Serratia marcescens; Spectrophotometry; Stereoisomerism | 1974 |
Action of the neurotoxin -N-oxalyl-L- , -diaminopropionic acid on glutamate metabolism of brain mitochondria.
Topics: Amino Acids; Animals; Brain; Brain Chemistry; Cattle; Excitatory Amino Acid Antagonists; Glutamates; Glutaminase; Glutamine; Ketoglutaric Acids; Mitochondria; Nerve Tissue Proteins; Oxalates; Oxygen Consumption; Propionates; Succinates; Toxins, Biological | 1972 |
Measurement of the specific radioactivity of glutamine and glutamate in plasma.
Topics: Carbon Isotopes; Glutamates; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Methods; Radiometry | 1972 |
[Mechanism of intrahepatic accumulation of dicarboxylic amino acids during ammonia poisoning].
Topics: Alanine; Amino Acids; Ammonia; Animals; Arginine; Aspartic Acid; Citrates; Citrulline; Dicarboxylic Acids; Glutamates; Glutaminase; Glutamine; Liver; Malates; Ornithine; Pyruvates; Rats; Seizures; Urea | 1972 |
Symposium on acid-base homeostasis. Control of renal production of ammonia.
Topics: Acid-Base Equilibrium; Acidosis; Alkalosis; Ammonia; Ammonium Chloride; Animals; Carbon Dioxide; Cell Membrane Permeability; Depression, Chemical; Gluconeogenesis; Glutamate Dehydrogenase; Glutamates; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Ketoglutaric Acids; Kidney; Kidney Tubules; Urine | 1972 |
Effects of metolazone in man: comparison with chlorothiazide.
Topics: Acid-Base Equilibrium; Acidosis; Alkalosis; Ammonia; Ammonium Chloride; Carbon Dioxide; Cell Membrane Permeability; Depression, Chemical; Gluconeogenesis; Glutamate Dehydrogenase; Glutamates; Glutaminase; Glutamine; Humans; Hydrogen-Ion Concentration; Ketoglutaric Acids; Kidney; Kidney Tubules; Male; Urine | 1972 |
[Characteristics of brain glutaminase].
Topics: 1-Propanol; Ammonia; Animals; Aspartic Acid; Bicarbonates; Brain; Glutamates; Glutaminase; Glutamine; Hot Temperature; In Vitro Techniques; Mitochondria; Phosphates; Potassium Chloride; Propanols; Rabbits; Sulfhydryl Compounds | 1972 |
Effects of glutamine deamination on glutamine deamidation in rat kidney slices.
Topics: Acidosis; Ammonia; Animals; Dinitrophenols; Glutamates; Glutaminase; Glutamine; In Vitro Techniques; Kidney; Malonates; Methylene Blue; Mitochondrial Swelling; Nitrogen; Rats | 1973 |
Glutamate and glutamine distribution in the rat nephron in acidosis and alkalosis.
Topics: Acidosis; Alkalosis; Ammonia; Animals; Fluorometry; Glutamates; Glutaminase; Glutamine; In Vitro Techniques; Kidney Glomerulus; Kidney Medulla; Kidney Tubules; Kidney Tubules, Distal; Kidney Tubules, Proximal; Male; Rats; Time Factors | 1973 |
Effect of acid-base changes and dehydration on renal medullary production of ammonia.
Topics: Acid-Base Equilibrium; Acidosis; Ammonia; Animals; Dehydration; Dogs; Extracellular Space; Glutamates; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Kidney; Kidney Cortex; Kidney Medulla; Male; Phosphates; Rats; Vasopressins; Water | 1973 |
Brain and serum glutamine in nephrectomized, uremic rats.
Topics: Animals; Brain Chemistry; Glutaminase; Glutamine; Male; Nephrectomy; Rats; Uremia | 1973 |
Transport of glutamine and glutamate in kidney mitochondria in relation to glutamine deamidation.
Topics: Adenosine Diphosphate; Ammonia; Animals; Antimycin A; Aspartic Acid; Biological Transport; Carbon Isotopes; Glutamates; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Kidney; Kidney Cortex; Membranes; Mitochondria; Mitochondrial Swelling; Models, Biological; Oxygen Consumption; Rotenone; Swine; Tritium | 1973 |
Blood cell and plasma amino acid levels across forearm muscle during a protein meal.
Topics: Adult; Amino Acids; Autoanalysis; Axillary Vein; Blood Cells; Blood Glucose; Brachial Artery; Dietary Proteins; Fatty Acids, Nonesterified; Female; Fluorometry; Forearm; Glucagon; Glutamate Dehydrogenase; Glutamates; Glutaminase; Glutamine; Glycerol; Hematocrit; Humans; Insulin; Lactates; Muscles; Pyruvates | 1973 |
[Characteristics of asparaginase and glutaminase synthesis in Ps. boreopolis 526].
Topics: Asparaginase; Asparagine; Aspartic Acid; Glutamates; Glutaminase; Glutamine; Ligases; Pseudomonas | 1973 |
Therapeutic properties of a new glutaminase-asparaginase preparation and the influence of the lactate dehydrogenase-elevating virus.
Topics: Animals; Antineoplastic Agents; Asparaginase; Asparagine; Aspartic Acid; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Glutamates; Glutaminase; Glutamine; Half-Life; Hydrogen-Ion Concentration; Isoelectric Focusing; L-Lactate Dehydrogenase; Leukemia, Experimental; Mice; Mice, Inbred C57BL; RNA Viruses | 1974 |
Influence of adrenal glands on pathways of renal glutamine utilization and ammonia production.
Topics: Adrenal Cortex Hormones; Adrenal Glands; Ammonia; Animals; Cytoplasm; Glutaminase; Glutamine; Kidney; Mitochondria; Rats | 1974 |
Evidence for passive glutamine uptake coupled to glutaminase I.
Topics: Acidosis; Ammonia; Animals; Chronic Disease; Glutamates; Glutaminase; Glutamine; Kidney; Rats | 1974 |
Improved assay for spinal fluid glutamine, and values for children with Reye's syndrome.
Topics: Ammonia; Brain Diseases; Deamination; Fatty Liver; Glutaminase; Glutamine; Humans; Methods; Reye Syndrome | 1974 |
The effects of pH change on renal ammoniagenesis in vitro.
Topics: Aerobiosis; Ammonia; Anaerobiosis; Animals; Bicarbonates; Glutamates; Glutaminase; Glutamine; Hydrogen-Ion Concentration; In Vitro Techniques; Kidney; Male; Phosphates; Rats | 1974 |
L-Asparaginase production by the rumen anaerobe Vibrio succinogenes.
Topics: Anaerobiosis; Animals; Asparaginase; Asparagine; Aspartic Acid; Carbon Radioisotopes; Cell-Free System; Culture Media; Electron Transport; Fumarates; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Malates; Nitrates; Rumen; Stereoisomerism; Succinates; Vibrio | 1974 |
Glutaminase activity of L-asparagine amidohydrolase.
Topics: Asparaginase; Asparagine; Azaserine; Carbon Isotopes; Escherichia coli; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Kinetics; Leucine | 1969 |
Antineoplastic activity of highly purified bacterial glutaminases.
Topics: Animals; Antineoplastic Agents; Asparaginase; Asparagine; Bacteria; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Escherichia coli; Female; Glutaminase; Glutamine; Leucine; Mice; Neoplasm Proteins | 1970 |
A rapid radioactive assay for glutamine synthetase, glutaminase, asparagine synthetase, and asparaginase.
Topics: Asparaginase; Asparagine; Aspartic Acid; Carbon Isotopes; Chromatography, Ion Exchange; Escherichia coli; Glutamates; Glutaminase; Glutamine; Ligases | 1970 |
Peptidoglutaminase. Enzymes for selective deamidation of gamma-amide of peptide-bound glutamine.
Topics: Amides; Amino Acids; Amino Alcohols; Asparagine; Bacillus; Carbon Isotopes; Caseins; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chromatography, Thin Layer; Electrophoresis; Escherichia coli; Glutaminase; Glutamine; Glycine; Hydroxamic Acids; Hydroxyapatites; Methods; Paper; Peptide Hydrolases; Peptides; Phenylalanine; Soil Microbiology | 1971 |
[Effect of beta-hydroxybutyric acid on the deamidization of glutamine by Escherichia coli glutaminase].
Topics: Acidosis; Acids; Ammonia; Animals; Escherichia coli; Glutaminase; Glutamine; Guinea Pigs; Humans; Hydroxybutyrates; In Vitro Techniques; Kidney; Methods; Rabbits; Rats; Sodium; Swine | 1971 |
Glutaminase induced prolonged regression of established Ehrlich carcinoma.
Topics: Acyltransferases; Animals; Asparaginase; Carcinoma, Ehrlich Tumor; Drug Synergism; Escherichia coli; Female; Glutaminase; Glutamine; Injections, Intraperitoneal; Leucine; Ligases; Mice; Neoplasm Proteins | 1971 |
Studies on the glutaminase activity of E. coli asparaginase in tissue culture.
Topics: Asparaginase; Asparagine; Carbon Isotopes; Depression, Chemical; Drug Resistance; Eosinophils; Escherichia coli; Glutamates; Glutaminase; Glutamine; HeLa Cells; Humans; Leucine; Leukocytes; Lymphocyte Activation; Mitosis; Monocytes; Neutrophils; Stimulation, Chemical; Thymidine; Uridine | 1970 |
Critical influence of an enzyme-elevating virus upon long-term remissions of mouse leukemia following asparaginase therapy.
Topics: Acute Disease; Amino Acids; Animals; Asparaginase; Blood; Body Weight; Chromatography, Ion Exchange; Chronic Disease; Diet; Escherichia coli; Female; Glutaminase; Glutamine; L-Lactate Dehydrogenase; Leukemia, Experimental; Mice; Neoplasm Transplantation; RNA Viruses; Virus Diseases | 1970 |
'Glutamine(amide):2-oxoglutarate amino transferase oxido-reductase (NADP); an enzyme involved in the synthesis of glutamate by some bacteria.
Topics: Ammonia; Bacillus megaterium; Bacillus subtilis; Bacteria; Enterobacter; Erwinia; Glutamate Dehydrogenase; Glutamates; Glutaminase; Glutamine; Glutarates; Hydrogen-Ion Concentration; Ketoglutaric Acids; Magnesium; Oxidoreductases; Potassium; Pseudomonas; Sodium; Transaminases | 1970 |
A relationship between rat kidney mitochondrial swelling and glutaminase activation.
Topics: Acidosis; Adenosine Triphosphate; Ammonia; Animals; Biochemical Phenomena; Biochemistry; Cell-Free System; Edetic Acid; Enzyme Activation; Female; Glutaminase; Glutamine; Kidney; Microscopy, Electron; Mitochondria; Mitochondrial Swelling; Phlorhizin; Phosphates; Proteins; Rats; Spectrum Analysis | 1971 |
Anthranilate synthetase. Some physical and kinetic properties of the enzyme from Serratia marcescens.
Topics: Ammonia; Animals; Antigens; Centrifugation, Density Gradient; Chloromercuribenzoates; Chromatography, Gel; Cyclohexanecarboxylic Acids; Drug Synergism; Electrophoresis, Disc; Feedback; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Immune Sera; Immunodiffusion; Isoelectric Focusing; Kinetics; Molecular Weight; ortho-Aminobenzoates; Quaternary Ammonium Compounds; Rabbits; Serratia marcescens; Time Factors; Transaminases; Tryptophan | 1971 |
Renal metabolism of glutamine in dogs during infusion of -ketoglutaric acid.
Topics: Acidosis; Ammonia; Ammonium Chloride; Animals; Cell Membrane Permeability; Disease Models, Animal; Dogs; Female; Glutaminase; Glutamine; Ketoglutaric Acids; Kidney; Male; Membranes; Mitochondria; Permeability | 1972 |
Glutamine and glutamate metabolism in guinea pig kidney slices.
Topics: Acidosis; Ammonia; Ammonium Chloride; Animals; Blood; Deamination; Gluconeogenesis; Glutamates; Glutaminase; Glutamine; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Kidney; Ligases; Male; Rats; Urine | 1972 |
The effects of acidosis and alkalosis on the metabolism of glutamine and glutamate in renal cortex slices.
Topics: Acidosis; Alkalosis; Amino Acids; Ammonia; Animals; Carbon Dioxide; Carbon Isotopes; Glucose; Glutamates; Glutaminase; Glutamine; Kidney; Lactates; Lipid Metabolism; Male; Proteins; Pyruvates; Rats | 1972 |
[Studies on ammonia metabolism of placenta].
Topics: Ammonia; Female; Glutamates; Glutaminase; Glutamine; Humans; Maternal-Fetal Exchange; Placenta; Pregnancy; Urea | 1972 |
Metabolism of glutamine and glutamate by rat liver mitochondria.
Topics: Ammonia; Animals; Aspartic Acid; Citric Acid Cycle; Glutamates; Glutaminase; Glutamine; Kinetics; Membranes; Mitochondria, Liver; Oxygen Consumption; Rats; Rotenone; Succinates | 1972 |
Metabolism of glutamine and ammonia in rat liver: the effects of N-acetylglutamate and phosphate.
Topics: Acetates; Ammonia; Animals; Aspartic Acid; Carbon Isotopes; Enzyme Activation; Glutamates; Glutaminase; Glutamine; In Vitro Techniques; Iodine Isotopes; Kinetics; Mitochondria, Liver; Perfusion; Phosphates; Rats; Urea | 1972 |
Studies on the glutamine aminotransferase-omega-amidase pathway in human kidney in vitro.
Topics: Amides; Carbon Isotopes; Chromatography, Ion Exchange; Citrates; Enzyme Activation; Fluorine; Glutaminase; Glutamine; Humans; Ketoglutaric Acids; Kidney; Maleates; Malonates; Mitochondria; Phosphates; Pyruvates; Transaminases | 1972 |
Relationship of renal glucconeogenesis to control of ammonia formation.
Topics: Acetone; Acidosis; Ammonia; Animals; Animals, Newborn; Female; Gluconeogenesis; Glucose; Glutamates; Glutaminase; Glutamine; Glyceraldehyde; Glycerol; Hydrogen-Ion Concentration; In Vitro Techniques; Ketoglutaric Acids; Kidney; Malates; Male; Oxaloacetates; Pyruvates; Rats; Trioses | 1972 |
A natural inhibitor of liver glutamine aminotransferase.
Topics: Aminohydrolases; Animals; Chromatography, Thin Layer; Glutaminase; Glutamine; In Vitro Techniques; Liver; Rats; Transaminases | 1972 |
An electrode for the determination of glutamine.
Topics: Cellophane; Electrodes; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Methods; Nylons | 1971 |
An evaluation of the enzymes involved in glutamine metabolism by the kidney.
Topics: Animals; Bile Acids and Salts; Glutaminase; Glutamine; Hot Temperature; Kidney; Mitochondria; Rats | 1971 |
Mechanism of ammoniagenesis in human kidney.
Topics: Ammonia; Glutaminase; Glutamine; Humans; Isoenzymes; Kidney; Methylamines | 1971 |
Stereospecific synthesis of alpha-methyl-L-glutamine by glutamine synthetase.
Topics: Alkylation; Amidohydrolases; Amino Acids; Aspergillus; Chemical Phenomena; Chemistry; Escherichia coli; Glutamates; Glutaminase; Glutamine; Ligases; Models, Theoretical | 1965 |
[Peculiarities of intracellular localization of glutaminase and glutamine in the myocardium under normal conditions and disturbed condition of blood circulation].
Topics: Ammonia; Cell Nucleus; Coronary Disease; Glutaminase; Glutamine; Heart; Microsomes; Mitochondria, Muscle; Myocardium; Solubility | 1969 |
[Seasonal changes in the activity of enzymes, desaminizing glutamine in the brain of Spermophilus].
Topics: Ammonia; Animals; Asparagine; Brain; Glutaminase; Glutamine; Rodentia; Seasons; Transaminases | 1969 |
A dialysable glutamine hydrolysing enzyme from normal and malignant tissues.
Topics: Animals; Dialysis; Fibrosarcoma; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Kidney; Manometry; Mice; Sarcoma, Experimental | 1970 |
Relation between glucose and ammonia production in renal cortical slices.
Topics: Acidosis; Adrenalectomy; Alkalosis; Ammonia; Animals; Gluconeogenesis; Glutamate Dehydrogenase; Glutamates; Glutaminase; Glutamine; In Vitro Techniques; Kidney; Male; Rats | 1970 |
Rates of glutaminase I and glutamine synthetase reactions in rat kidney in vivo.
Topics: Acidosis; Alkalosis; Ammonia; Animals; Carbon Isotopes; Glomerular Filtration Rate; Glutamates; Glutaminase; Glutamine; Ketoglutaric Acids; Kidney; Kinetics; Ligases; Male; Rats | 1970 |
[Comparison of the results of ion-exchange chromatographic and enzymatic determination of human serum glutamine].
Topics: Chromatography, Ion Exchange; Clinical Enzyme Tests; Glutaminase; Glutamine; Humans; Liver Diseases; Methods | 1970 |
[Gluten-free diet in therapy of celiac disease. Facts and theories concerning the toxicity of gliadin].
Topics: Celiac Disease; Diet Therapy; Glutaminase; Glutamine; Glutens; Humans; Intestines; Liver; Peptide Hydrolases; Peptides; Plant Proteins; Triticum | 1970 |
Phylogenic aspects of different regulatory mechanisms of glutamine metabolism.
Topics: Animals; Biological Evolution; Chickens; Dietary Proteins; Enzyme Induction; Glutaminase; Glutamine; Liver; Male; Rats; Uric Acid | 1970 |
[Glutaminase activity and intensity of glutamine metabolism in the lungs and lymph nodes in tuberculosis].
Topics: Adolescent; Adult; Female; Glutaminase; Glutamine; Humans; Lung; Lymph Nodes; Male; Middle Aged; Tuberculosis, Lymph Node; Tuberculosis, Pulmonary | 1970 |
Changes in turnover rates of some enzymes involved in nitrogen metabolism in the rat liver after administration of carbon tetrachloride.
Topics: Administration, Oral; Animals; Arginase; Arginine; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Caseins; Depression, Chemical; Dietary Proteins; Glutaminase; Glutamine; Hydro-Lyases; Ligases; Liver; Lyases; Male; Nitrogen; Ornithine Carbamoyltransferase; Puromycin; Rats; Succinates; Threonine | 1970 |
Conditions for activity of glutaminase in kidney mitochondria.
Topics: Ammonia; Animals; Anti-Bacterial Agents; Antimycin A; Glutamate Dehydrogenase; Glutamates; Glutaminase; Glutamine; Hydrogen-Ion Concentration; In Vitro Techniques; Kidney; Membranes; Mitochondria; Mitochondrial Swelling; Nitriles; Oxygen Consumption; Permeability; Phenylhydrazines; Potassium; Rats; Rotenone; Succinates; Uncoupling Agents | 1970 |
Ammonia metabolism in kidneys of suckling rats.
Topics: Age Factors; Aminohippuric Acids; Ammonia; Ammonium Chloride; Animals; Animals, Newborn; Glutamates; Glutaminase; Glutamine; Kidney; Ligases; Rats | 1971 |
Effect of chronic alkalosis and acidosis on glutaminase II path in the dog kidney in vivo.
Topics: Acid-Base Equilibrium; Acidosis; Alkalosis; Amides; Ammonia; Animals; Carbon Isotopes; Dogs; Female; Glutamates; Glutaminase; Glutamine; Kidney | 1971 |
Familial protein intolerance. Possible nature of enzyme defect.
Topics: Adult; Alanine; Amino Acid Metabolism, Inborn Errors; Amino Acids; Ammonia; Atrophy; Biological Transport; Blood Cell Count; Blood Glucose; Blood Urea Nitrogen; Bone Diseases; Brain Diseases; Dietary Proteins; Female; Glutaminase; Glutamine; Hemoglobins; Humans; Intellectual Disability; Kidney; Kidney Function Tests; Lysine; Metabolism, Inborn Errors; Nitrogen; Proteins; Specific Gravity; Urea; Urine | 1971 |
Relation of renal gluconeogenesis to ammonia production in the rabbit.
Topics: Ammonia; Animals; Gluconeogenesis; Glutamates; Glutaminase; Glutamine; In Vitro Techniques; Ketoglutaric Acids; Kidney; Pyruvates; Rabbits; Rats; Species Specificity | 1971 |
Amino acid levels in plasma, liver, muscle, and kidney during and after exercise in fasted and fed rats.
Topics: Acidosis; Alanine; Amino Acids; Animals; Aspartic Acid; Fasting; Gluconeogenesis; Glutamates; Glutaminase; Glutamine; Glycine; Kidney; Liver; Lysine; Male; Muscles; Physical Exertion; Rats; Serine; Swimming | 1971 |
Glutamyl, aspartyl and amide moieties of cerebral proteins: metabolic aspects in vitro.
Topics: Amides; Ammonia; Ammonium Chloride; Animals; Asparaginase; Asparagine; Aspartic Acid; Autoradiography; Carbon Isotopes; Carboxy-Lyases; Cats; Cerebral Cortex; Glutamates; Glutaminase; Glutamine; Hydrolases; Hydrolysis; In Vitro Techniques; Mass Spectrometry; Nerve Tissue Proteins; Nitrogen Isotopes; Protein Binding | 1971 |
[Glutaminase dependent glutamate and ammonia synthesis in the brain].
Topics: Ammonia; Animals; Brain; Glutamates; Glutaminase; Glutamine; In Vitro Techniques; Swine | 1971 |
[Glutamic acid and glutamine in glial brain tumor tissue].
Topics: Ammonia; Animals; Brain Neoplasms; Glioma; Glutamates; Glutaminase; Glutamine; Mice; Neoplasms, Experimental; Neuroglia; Rabbits | 1967 |
[Determination of glutamine in serum and cerebrospinal fluid with glutaminase].
Topics: Ammonia; Animals; Glutaminase; Glutamine; Mitochondria, Liver; Swine | 1967 |
Glutaminase of Escherichia coli. II. Studies on the exchange of oxygen between water and substrates.
Topics: Glutamates; Glutaminase; Glutamine; Kinetics; Oxygen; Oxygen Isotopes; Water | 1968 |
Glutaminase of Escherichia coli. 3. Studies on the reaction mechanism.
Topics: Acetates; Chemical Phenomena; Chemistry; Cold Temperature; Deuterium; Glutamates; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Hydroxylamines; Kinetics | 1968 |
An analysis of the non-enzymic ammonia production from glutamine.
Topics: Ammonia; Chemical Phenomena; Chemistry; Glutaminase; Glutamine | 1968 |
Renal protein and ammonia biochemistry in NH4Cl acidosis and after uninephrectomy.
Topics: Acidosis; Ammonia; Ammonium Chloride; Animals; Carbon Isotopes; Dactinomycin; Female; Glutaminase; Glutamine; Hyperplasia; Kidney; Leucine; Methods; Nephrectomy; Protein Biosynthesis; Proteins; Rats; Regional Blood Flow; RNA | 1968 |
Allosteric nature of a glutaminase isozyme in rat liver.
Topics: Animals; Centrifugation, Density Gradient; Glutaminase; Glutamine; Isoenzymes; Kinetics; L-Lactate Dehydrogenase; Liver; Maleates; Phosphates; Rats | 1968 |
The specificity of transglutaminase. I. Human hemoglobin as a substrate for the enzyme.
Topics: Amines; Amino Acid Sequence; Animals; Glutaminase; Glutamine; Guinea Pigs; Hemoglobins; Hot Temperature; Liver; Peptides; Protein Denaturation; Time Factors | 1968 |
Factors affecting the deamidation of glutamine by kidney mitochondria of normal and acidotic rats.
Topics: Acetates; Acidosis; Acids; Ammonia; Animals; Dicarboxylic Acids; Ethionine; Female; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Kidney; Mitochondria; Oxaloacetates; Phosphates; Pyruvates; Rats | 1968 |
Effect of thyroid hormones on some enzymes of nitrogen metabolism.
Topics: Ammonia; Animals; Antithyroid Agents; Aspartic Acid; Dactinomycin; Depression, Chemical; Diet; Ethionine; Glutaminase; Glutamine; Hyperthyroidism; Hypothyroidism; Kidney; Ligases; Liver; Male; Ornithine; Phosphotransferases; Propylthiouracil; Puromycin; Rats; Stimulation, Chemical; Thyroid Hormones; Transaminases; Transferases; Urea | 1968 |
Distribution of some enzymes associated with the metabolism of glutamate, aspartate, gamma-aminobutyrate and glutamine in cat spinal cord.
Topics: Aminobutyrates; Animals; Aspartate Aminotransferases; Aspartic Acid; Carboxy-Lyases; Cats; Fluorometry; Glutamate Dehydrogenase; Glutamates; Glutaminase; Glutamine; Ligases; Spectrophotometry; Spinal Cord; Spinal Nerves; Transaminases | 1969 |
Determination of protein-bound glutamine.
Topics: Amines; Animals; Carbon Isotopes; Cattle; Clostridium; Ferredoxins; Formates; Glutaminase; Glutamine; Glycine; Hemoglobins; Humans; Insulin; Muramidase; Protein Binding; Proteins; Ribonucleases; Time Factors | 1969 |
An improved method for the microdetermination of glutamine in plasma and urine.
Topics: Adult; Chromatography, Ion Exchange; Colorimetry; Female; Glutamates; Glutaminase; Glutamine; Humans; Hydrogen-Ion Concentration; Indicators and Reagents; Male; Methods; Microchemistry; Quaternary Ammonium Compounds; Temperature | 1969 |
Glutamate oxidation in rat-liver homogenate.
Topics: Adenine Nucleotides; Ammonia; Animals; Arginine; Aspartic Acid; Citrulline; Glutamates; Glutaminase; Glutamine; Kinetics; Liver; Nitrogen; Rats; Urea; Urease | 1969 |
Behaviour of glutaminase in normal cells cultured in vitro.
Topics: Animals; Culture Techniques; Glutaminase; Glutamine; Kidney; Rats; Trypsin | 1969 |
Activators and inhibitors of brain glutaminase.
Topics: Acids; Amino Acids; Animals; Brain; Bromides; Centrifugation; Chlorides; Citrates; Citric Acid Cycle; Dicarboxylic Acids; Enzyme Induction; Enzyme Repression; Fluorides; Glutaminase; Glutamine; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Iodides; Methionine Sulfoximine; Phosphates; Phosphocreatine; Sulfhydryl Compounds | 1969 |
Glutaminases. An ultramicro method for the determination of glutaminase activity, and a reinvestigation of optimum assay conditions in the kidney of man, dog and rat.
Topics: Ammonia; Animals; Carbonates; Dogs; Glutaminase; Glutamine; Humans; In Vitro Techniques; Kidney; Microchemistry; Phosphates; Pyruvates; Rats | 1964 |
[Potential anticancer agents. Synthesis of derivatives of N-phthalylglutamine and related compounds].
Topics: Antineoplastic Agents; Enzymes; Glutaminase; Glutamine | 1966 |
The enzymic estimation of glutamate and glutamine.
Topics: Chemical Phenomena; Chemistry; Cyanides; Glutamate Dehydrogenase; Glutamates; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Oxygen; Phenazines; Spectrophotometry; Temperature; Tetrazolium Salts | 1966 |
[Distribution of glutaminase and glutamine in various elements of gastric muscle cells].
Topics: Animals; Cell Nucleus; Glutaminase; Glutamine; Methods; Microsomes; Mitochondria, Muscle; Muscle, Smooth; Myofibrils; Rabbits; Stomach | 1966 |
The metabolism of amino acids in developing rat brain.
Topics: Amino Acids; Aminobutyrates; Animals; Animals, Newborn; Aspartate Aminotransferases; Brain; Carboxy-Lyases; Chromatography; Glutamate Dehydrogenase; Glutamates; Glutaminase; Glutamine; Glutathione; Ligases; Nerve Tissue Proteins; Rats; Transaminases | 1967 |
Pathways of glutamine deamination and their control in the rat kidney.
Topics: Acidosis; Alanine Transaminase; Ammonia; Animals; Antimetabolites; Glutaminase; Glutamine; In Vitro Techniques; Kidney; Male; Phosphates; Rats | 1967 |
Glutamine metabolism in carbon tetrachloride-treated acidotic rats.
Topics: Acidosis; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Kinetics; Liver; Male; Rats | 1980 |
Adaptation of gamma-glutamyltransferase to acidosis.
Topics: Acidosis; Adaptation, Physiological; Animals; gamma-Glutamyltransferase; Glutaminase; Glutamine; In Vitro Techniques; Kidney; Male; Molecular Weight; Rats; Subcellular Fractions | 1980 |
Evidence for compartmentalization of glutamate in rat brain synaptosomes using the glutamate sensitivity of phosphate-activated glutaminase as a functional test.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Enzyme Activation; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Phosphates; Rats; Synaptosomes | 1981 |
Differential effect of AT-125 on rat renal glutaminase activities.
Topics: Ammonia; Animals; gamma-Glutamyltransferase; Glutaminase; Glutamine; Glycine; Isoxazoles; Kidney; Kinetics; Male; Oxazoles; Phosphates; Rats | 1981 |
[Activity of renal enzymes producing ammonia from glutamine in the absence of phosphate in the rat: 1. Effect of chronic metabolic acidosis].
Topics: Acidosis; Ammonia; Animals; Chronic Disease; gamma-Glutamyltransferase; Glutaminase; Glutamine; Kidney Cortex; Male; Phosphates; Rats; Rats, Inbred Strains | 1981 |
[Activity of renal enzymes producing ammonia from glutamine in the absence of phosphate: 2. Effect of phosphate dependent glutaminase inhibition by heating].
Topics: Ammonia; Animals; gamma-Glutamyltransferase; Glutaminase; Glutamine; Hot Temperature; Kidney Cortex; Male; Phosphates; Rats; Rats, Inbred Strains | 1981 |
Determination of [amide-15N]glutamine in plasma with gas chromatography-mass spectrometry.
Topics: Ammonia; Gas Chromatography-Mass Spectrometry; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Humans; Nitrogen Isotopes | 1982 |
Glutamine distribution in mitochondria from normal and acidotic rat kidneys.
Topics: Acidosis, Renal Tubular; Animals; Cell Membrane Permeability; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Kidney; Male; Mannitol; Mitochondria; Rats; Rats, Inbred Strains | 1982 |
Renal metabolism of glutamine in rats with acute renal failure.
Topics: Acute Kidney Injury; Animals; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Glycerol; Kidney Cortex; Rats | 1982 |
Regulation of flux through glutaminase and glutamine synthetase in isolated perfused rat liver.
Topics: Ammonium Chloride; Animals; Glucagon; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Kinetics; Liver; Male; Perfusion; Rats; Rats, Inbred Strains | 1983 |
Glutamine metabolism in bone.
Topics: Amino Acids; Ammonia; Animals; Biological Transport; Bone and Bones; Carbon Dioxide; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Phosphates; Rats; Skull; Sodium; Transaminases | 1983 |
Effects of glucocorticoids on glutamine metabolism in skeletal muscle.
Topics: Amino Acids; Animals; Dexamethasone; Dogs; Female; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Hindlimb; Male; Muscles; Nitrogen; Regional Blood Flow; Time Factors | 1984 |
Regulation of glutamine synthetase and glutaminase activities in cultured skeletal muscle cells.
Topics: Animals; Cell Line; Dexamethasone; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Kinetics; Muscles; Phosphates; Rats | 1984 |
Intrauterine malnutrition and the brain: effects on enzymes and free amino acids related to glutamate metabolism.
Topics: Amino Acids; Animals; Body Weight; Brain; DNA; Female; Glutamate Decarboxylase; Glutamate-Ammonia Ligase; Glutamates; Glutaminase; Glutamine; Nerve Tissue Proteins; Organ Size; Pregnancy; Protein Deficiency; Rats; RNA | 1980 |
Formation and properties of L-glutaminase and L-asparaginase activities in Pichia polymorpha.
Topics: Ascomycota; Asparaginase; Asparagine; Cations, Divalent; Enzyme Induction; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Pichia; Substrate Specificity; Temperature | 1980 |
Effect of bicarbonate on glutamine metabolism.
Topics: Animals; Bicarbonates; Cyclic AMP; Glucagon; Glutaminase; Glutamine; In Vitro Techniques; Intestinal Mucosa; Intestine, Small; Kidney; Kidney Cortex; Kidney Tubules; Liver; Organ Specificity; Rats | 1980 |
Factors increasing glutaminase flux in hepatocytes.
Topics: Ammonium Chloride; Animals; Bucladesine; Cysteine; Dinitrophenols; Glutaminase; Glutamine; In Vitro Techniques; Liver; Mitochondria, Liver; Rats; Stimulation, Chemical | 1982 |
Accelerated recovery from metabolic acidosis.
Topics: Acidosis; Ammonia; Animals; Bicarbonates; Glutamate Dehydrogenase; Glutaminase; Glutamine; Kidney; Male; Phosphoenolpyruvate Carboxykinase (GTP); Rats; Rats, Inbred Strains; Sodium Bicarbonate | 1982 |
Asparagine and glutamine metabolism in chicks.
Topics: Amino Acids; Ammonium Chloride; Animals; Asparaginase; Asparagine; Bicarbonates; Chickens; Dietary Proteins; Glutaminase; Glutamine; Kidney; Liver; Mitochondria; Mitochondria, Liver; Sodium Bicarbonate | 1984 |
Inhibition of blastogenesis by native and polyethylene glycol-modified asparaginases from Escherichia coli and Vibrio succinogenes.
Topics: Animals; Asparaginase; Asparagine; Cells, Cultured; Escherichia coli; Glutaminase; Glutamine; Immunosuppressive Agents; Lymphocyte Activation; Male; Polyethylene Glycols; Rats; Rats, Inbred F344; Vibrio | 1983 |
The significance of the attachment of rat kidney glutaminase to the inner mitochondrial membrane.
Topics: Animals; Enzyme Activation; Glutaminase; Glutamine; Intracellular Membranes; Kidney; Kinetics; Male; Mitochondria; Octoxynol; Phosphates; Polyethylene Glycols; Rats; Rats, Inbred Strains; Sonication | 1984 |
The regulation of phosphate-activated glutaminase activity and glutamine metabolism in the streptozotocin-diabetic rat.
Topics: Animals; Diabetes Mellitus, Experimental; Enzyme Activation; Glutaminase; Glutamine; Intestine, Small; Kidney; Liver; Male; Phosphates; Rats; Rats, Inbred Strains | 1984 |
Prominent glutamine oxidation activity in mitochondria of hematopoietic tumors.
Topics: Adenosine Triphosphate; Animals; Cell Fractionation; Glutamates; Glutaminase; Glutamine; Kinetics; Leukemia, Erythroblastic, Acute; Leukemia, Myeloid; Male; Mice; Mitochondria; Neoplasms, Experimental; Polarography; Rabbits; Rats; Rotenone | 1983 |
Glutamine oxidation by dissociated cells and homogenates of rat brain: kinetics and inhibitor studies.
Topics: Aminooxyacetic Acid; Animals; Aspartate Aminotransferases; Brain; Glucose; Glutamate Decarboxylase; Glutamate Dehydrogenase; Glutaminase; Glutamine; Kinetics; Oxidation-Reduction; Rats; Rats, Inbred Strains | 1984 |
Partial purification and properties of rat liver glutaminase.
Topics: Ammonium Chloride; Animals; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Glutaminase; Glutamine; Kinetics; Mitochondria, Liver; Molecular Weight; Phosphates; Rats | 1984 |
Calcium stimulation of glutamine hydrolysis in synaptosomes from rat brain.
Topics: Animals; Brain; Calcium; Enzyme Activation; Glutaminase; Glutamine; Hydrolysis; Mitochondria; Phosphates; Rats; Rats, Inbred Strains; Synaptosomes | 1983 |
Significance, mechanisms and control of renal ammoniagenesis.
Topics: Acid-Base Equilibrium; Acidosis; Ammonia; Animals; Dogs; Glutaminase; Glutamine; Humans; Hydrogen-Ion Concentration; Kidney; Kidney Calculi; Potassium Deficiency; Rats; Uric Acid | 1981 |
Kinetics of glutamine-efflux from liver mitochondria loaded with the 14C-Labeled substrate.
Topics: Animals; Biological Transport; Glutaminase; Glutamine; Intracellular Membranes; Kidney; Kinetics; Mersalyl; Mitochondria; Mitochondria, Liver; Rats; Succinates; Succinic Acid | 1982 |
Distribution of glutamine in rat kidney mitochondria.
Topics: Acidosis; Animals; Glutaminase; Glutamine; Kidney Cortex; Mitochondria; Phosphates; Rats | 1982 |
Rebound metabolic alkalosis in the rat. A study of the renal response to and recovery from metabolic acidosis.
Topics: Acidosis; Alkalosis; Ammonia; Ammonium Chloride; Animals; Biological Transport, Active; Glutamate Dehydrogenase; Glutaminase; Glutamine; Ketoglutaric Acids; Kidney; Phosphoenolpyruvate Carboxykinase (GTP); Rats; Rats, Inbred Strains | 1982 |
A radioisotope assay for L-glutaminase: the measurement of tritiated water formation from the reaction of L-[2-3H]glutamine with the L-glutaminase and glutamate oxalacetate transaminase couple.
Topics: Aspartate Aminotransferases; Cells, Cultured; Chemical Phenomena; Chemistry; Glutaminase; Glutamine; Humans; Spectrophotometry; Stereoisomerism; Tritium; Water | 1982 |
Glutamine: a new metabolic substrate.
Topics: Amino Acids; Ammonia; Animals; Bone and Bones; Glutaminase; Glutamine; Glycolysis; In Vitro Techniques; Rats | 1982 |
Evidence that 3-aminopicolinate stimulates glutamine metabolism by rat renal cortical tissue in vitro.
Topics: Animals; Enzyme Activation; Glutaminase; Glutamine; In Vitro Techniques; Kidney Cortex; Kidney Tubules; Male; Picolinic Acids; Rats | 1982 |
Asparagine and glutamine metabolism in Rhodopseudomonas acidophila.
Topics: Asparaginase; Asparagine; Glutaminase; Glutamine; Glycine; Glyoxylates; Methionine Sulfoximine; Rhodopseudomonas; Transaminases | 1980 |
Control of glutaminase activity in rat brain cortex in vitro: influence of glutamate, phosphate, ammonium, calcium and hydrogen ions.
Topics: Amino Acids; Ammonia; Animals; Calcium; Cerebral Cortex; Culture Techniques; Glutamates; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Male; Phosphates; Rats | 1981 |
Localization and some properties of phosphate-dependent glutaminase in disrupted liver mitochondria.
Topics: Animals; Enzyme Activation; Female; Freezing; Glutaminase; Glutamine; In Vitro Techniques; Kinetics; Mitochondria, Liver; Phosphates; Rats; Sonication | 1980 |
Kinetic comparisons between soluble and membrane-bound glutaminase preparations from pig brain.
Topics: Animals; Brain; Cell Membrane; Cytosol; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Kinetics; Substrate Specificity; Swine | 1981 |
Occurrence of an inducible glutaminase in Bacillus licheniformis.
Topics: Bacillus; Enzyme Induction; Enzyme Repression; Glucose; Glutaminase; Glutamine; Hydrogen-Ion Concentration | 1981 |
Increased activity of phosphate-dependent glutaminase in liver mitochondria as a result of glucagon treatment of rats.
Topics: Animals; Bicarbonates; Enzyme Activation; Female; Glucagon; Glutaminase; Glutamine; Mitochondria, Liver; Osmolar Concentration; Phosphates; Rats | 1981 |
Enzyme therapy of cancer, future studies.
Topics: Adolescent; Amidohydrolases; Animals; Antineoplastic Agents; Arginine; Asparaginase; Asparagine; Child; Child, Preschool; Drug Evaluation; Drug Evaluation, Preclinical; Enzyme Therapy; Enzymes; Female; Glutaminase; Glutamine; Humans; Kinetics; Leukemia; Male; Mice | 1981 |
Substrate mediated regulation of phosphate-activated glutaminase in nervous tissue.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Enzyme Activation; Glutamates; Glutaminase; Glutamine; Phosphates; Rats; Synaptosomes | 1980 |
Adaptation of renal ammonia production to metabolic acidosis: a study in metabolic regulation.
Topics: Acidosis; Ammonia; Animals; Glutamate Dehydrogenase; Glutaminase; Glutamine; Humans; In Vitro Techniques; Kidney; Kidney Tubules; Mitochondria; Rats; Regeneration | 1980 |
Increase in glutaminase activity during the growth cycle of cultured human diploid fibroblasts.
Topics: Cell Cycle; Cells, Cultured; Diploidy; Fibroblasts; Glutaminase; Glutamine; Humans | 1980 |
Volume changes of rat kidney mitochondria, transport of glutamine and its inhibition by mersalyl.
Topics: Animals; Biological Transport; Female; Glutaminase; Glutamine; Kidney; Kinetics; Male; Mersalyl; Mitochondria; Mitochondrial Swelling; Organomercury Compounds; Osmolar Concentration; Rats; Sulfhydryl Reagents | 1980 |
The role of pH and the lack of a requirement for hydorgencarbonate in the regulation of hepatic glutamine metabolism.
Topics: Alanine; Ammonia; Animals; Bicarbonates; Glutamates; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Kinetics; Liver; Male; Perfusion; Rats; Urea | 1980 |
Dependence of in vivo glutamine synthetase activity on ammonia concentration in rat brain studied by 1H - 15N heteronuclear multiple-quantum coherence-transfer NMR.
Topics: Adenosine Triphosphate; Ammonia; Animals; Blood-Brain Barrier; Brain; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Glutamate-Ammonia Ligase; Glutamates; Glutaminase; Glutamine; Infusions, Intravenous; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Wistar | 1995 |
Effect of germfree state on the capacities of isolated rat colonocytes to metabolize n-butyrate, glucose, and glutamine.
Topics: Animals; Butyrates; Cells, Cultured; Colon; Germ-Free Life; Glucose; Glutaminase; Glutamine; Hydroxymethylglutaryl-CoA Synthase; Intestinal Mucosa; Male; Mitochondria; Oxidation-Reduction; Phosphofructokinase-1; Rats; Rats, Inbred F344; RNA, Messenger | 1995 |
Cytokines decrease glutaminase expression in human fibroblasts.
Topics: Cells, Cultured; Cytokines; Fibroblasts; Glutaminase; Glutamine; Humans; Interferons; Interleukin-1; Interleukin-6; RNA, Messenger; Tumor Necrosis Factor-alpha | 1994 |
Hormonal control of hepatic glutaminase.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Experimental; Dietary Proteins; Endotoxins; Enzyme Activation; Enzyme Inhibitors; Ethers, Cyclic; Glucagon; Glutamic Acid; Glutaminase; Glutamine; Mitochondria, Liver; Okadaic Acid; Phosphates; Rats; Signal Transduction; Thionucleotides | 1995 |
Glutamine cycle enzymes in the crayfish giant nerve fiber: implications for axon-to-glia signaling.
Topics: Animals; Astacoidea; Axons; Cell Communication; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Immunohistochemistry; Microscopy, Electron; Nerve Fibers; Neuroglia; Rabbits | 1995 |
Extracellular glutamate flux regulates intracellular glutaminase activity in LLC-PK1-F+ cells.
Topics: Animals; Aspartic Acid; Cell Line; Extracellular Space; gamma-Glutamyltransferase; Glutamic Acid; Glutaminase; Glutamine; Intracellular Fluid; Isoxazoles; Kidney Tubules, Proximal; Kinetics; LLC-PK1 Cells; Models, Biological; Swine | 1995 |
Activation of hepatic glutaminase in the endotoxin-treated rat.
Topics: Animals; Endotoxins; Enzyme Activation; Escherichia coli; Glutaminase; Glutamine; Liver; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley | 1995 |
Hormonal regulation of glutamine metabolism by OK cells.
Topics: Adenosine Triphosphate; Animals; Cell Line; Cells, Cultured; Glucagon; Glutamate Dehydrogenase; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Insulin; Ketoglutaric Acids; Kidney; Opossums; Parathyroid Hormone | 1995 |
Neomycin reduces the intestinal production of ammonia from glutamine.
Topics: Ammonia; Animals; Brain Chemistry; Glutaminase; Glutamine; Intestinal Mucosa; Intestines; Male; Neomycin; Portacaval Shunt, Surgical; Rats; Time Factors | 1994 |
Effect of hypo- and hyperthyroidism on the function and metabolism of macrophages in rats.
Topics: Animals; Cell Movement; Citrate (si)-Synthase; Decarboxylation; Glucose; Glutaminase; Glutamine; Hexokinase; Hydrogen Peroxide; Hyperthyroidism; Hypothyroidism; Lactates; Macrophages, Peritoneal; Male; Mycobacterium bovis; Phagocytosis; Rats; Rats, Wistar; Thioglycolates | 1995 |
On-line monitoring of an animal cell culture with multi-channel flow injection analysis.
Topics: Animals; Culture Media; Enzymes, Immobilized; Flow Injection Analysis; Glucose; Glutaminase; Glutamine; Hybridomas; L-Lactate Dehydrogenase; Lactates; Lactic Acid; Quaternary Ammonium Compounds | 1994 |
In vivo activity of glutaminase in the brain of hyperammonaemic rats measured by 15N nuclear magnetic resonance.
Topics: Ammonia; Animals; Brain; Brain Chemistry; gamma-Aminobutyric Acid; Glutamic Acid; Glutaminase; Glutamine; Magnetic Resonance Spectroscopy; Male; Nitrogen Isotopes; Quantum Theory; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Sensitivity and Specificity | 1995 |
Glutamine transport and enzymatic activities involved in glutaminolysis in human platelets.
Topics: Alanine; Aspartate Aminotransferases; Biological Transport; Blood Platelets; Glutamate Dehydrogenase; Glutaminase; Glutamine; Humans; Hydrolysis; Membranes; Sodium; Threonine; Transaminases | 1995 |
Activation of hepatic glutaminase by spermine.
Topics: Ammonium Chloride; Animals; Enzyme Activation; Glutamic Acid; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Magnesium; Male; Mitochondria, Liver; Phosphates; Rats; Rats, Sprague-Dawley; Spermine | 1995 |
Studies in red blood cell preservation: 9. The role of glutamine in red cell preservation.
Topics: Adenine; Adenosine Triphosphate; Adult; Ammonium Chloride; Blood Preservation; Erythrocytes; Glucose; Glutaminase; Glutamine; Hematocrit; Hemolysis; Humans; Mannitol; Phosphates; Sodium Chloride; Solutions | 1994 |
Effects of glutamine deprivation on glutamine transport and synthesis in primary culture of rat skeletal muscle.
Topics: Amino Acids; Animals; Animals, Newborn; Asparagine; Biological Transport; Cell Differentiation; Cell Division; Cells, Cultured; Cycloheximide; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Histidine; Insulin; Kinetics; Methionine Sulfoximine; Muscles; Rats; Time Factors; Tritium | 1993 |
Aspartate aminotransferase and glutaminase activities in rat olfactory bulb and cochlear nucleus; comparisons with retina and with concentrations of substrate and product amino acids.
Topics: Amino Acids; Animals; Aspartate Aminotransferases; Aspartic Acid; Cochlear Nucleus; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Isoenzymes; Malate Dehydrogenase; Olfactory Bulb; Organ Specificity; Rats; Rats, Sprague-Dawley; Retina | 1994 |
Changes in mRNAs for enzymes of glutamine metabolism in kidney and liver during ammonium chloride acidosis.
Topics: Acidosis; Ammonium Chloride; Animals; Enzymes; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Kidney; Liver; Male; Phosphates; Phosphoenolpyruvate Carboxykinase (GTP); Rats; Rats, Wistar; RNA, Messenger | 1994 |
Inhibition of astrocyte glutamine production by alpha-ketoisocaproic acid.
Topics: Ammonium Chloride; Animals; Animals, Newborn; Astrocytes; Caproates; Cells, Cultured; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Keto Acids; Kinetics; L-Lactate Dehydrogenase; Nitrogen Isotopes; Prosencephalon; Rats; Rats, Sprague-Dawley | 1994 |
Modulation of cellular proliferation alters glutamine transport and metabolism in human hepatoma cells.
Topics: Amino Acid Transport Systems; Amino Acids; Animals; Biological Transport; Butyrates; Butyric Acid; Carcinoma, Hepatocellular; Carrier Proteins; Cell Division; Female; Glutaminase; Glutamine; Humans; Liver Neoplasms; Male; Novobiocin; Rats; Rats, Inbred F344; Time Factors; Tumor Cells, Cultured | 1994 |
Hormonal and dietary control of hepatic glutamine catabolism.
Topics: Animals; Dietary Proteins; Glucagon; Glutaminase; Glutamine; Liver; Male; Rats; Rats, Sprague-Dawley; Signal Transduction; Spermine | 1994 |
Time course of changes in mRNAs for enzymes of glutamine metabolism in kidney during metabolic acidosis.
Topics: Acidosis; Animals; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Kidney; Male; Phosphoenolpyruvate Carboxykinase (GTP); Rats; Rats, Wistar; RNA, Messenger | 1994 |
Glutamine catabolism by heart muscle: regulation of phosphate-activated glutaminase by ATP, citrate, and chloride.
Topics: Adenosine Triphosphate; Animals; Anions; Bromides; Chlorides; Citrates; Fluorides; Glutaminase; Glutamine; Kinetics; Mitochondria, Heart; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Thiocyanates | 1994 |
Glucocorticoid regulation of splanchnic glutamine, alanine, glutamate, ammonia, and glutathione fluxes.
Topics: Adrenalectomy; Alanine; Amino Acids; Ammonia; Animals; Biological Transport; Cell Membrane; Cells, Cultured; DNA Probes; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Glutathione; Liposomes; Liver; Male; Proteolipids; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Regional Blood Flow; RNA, Messenger; Splanchnic Circulation; Triamcinolone | 1993 |
A glutamatergic mechanism for aluminum toxicity in astrocytes.
Topics: Amino Acids; Animals; Astrocytes; Cells, Cultured; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Lactates; Lactic Acid; Rats | 1993 |
Synthesis of citrulline from glutamine in pig enterocytes.
Topics: Ammonia; Animals; Carbon-Nitrogen Ligases; Citrulline; Female; Glutaminase; Glutamine; Jejunum; Ligases; Male; Ornithine; Ornithine Carbamoyltransferase; Ornithine-Oxo-Acid Transaminase; Proline; Swine | 1994 |
Glycolytic, glutaminolytic and pentose-phosphate pathways in promyelocytic HL60 and DMSO-differentiated HL60 cells.
Topics: Cell Differentiation; Citrate (si)-Synthase; Dimethyl Sulfoxide; Glucose; Glucosephosphate Dehydrogenase; Glutaminase; Glutamine; Glycogen Synthase; Glycolysis; Granulocytes; Hexokinase; Humans; Leukemia, Promyelocytic, Acute; Malate Dehydrogenase; Pentose Phosphate Pathway; Phosphofructokinase-1; Phosphogluconate Dehydrogenase; Pyruvate Kinase; Tumor Cells, Cultured | 1993 |
Rapid activation of hepatic glutaminase in rats fed on a single high-protein meal.
Topics: Ammonia; Animals; Citrulline; Dietary Proteins; Enzyme Activation; Glutaminase; Glutamine; Liver; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley | 1993 |
Dexamethasone stimulation of glutaminase expression in mesenteric lymph nodes.
Topics: Animals; Dexamethasone; Gene Expression Regulation, Enzymologic; Glutaminase; Glutamine; Laparotomy; Lymph Nodes; Lymphocytes; Male; Mesentery; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stress, Physiological | 1993 |
Effects of various dietary fatty acids on enzyme activities of carbohydrate and glutamine metabolism and the metabolic response of lymphocytes and macrophages during Walker-256 ascites cell tumour growth in rats.
Topics: Animals; Carbohydrate Metabolism; Carcinoma 256, Walker; Dietary Fats; Enzyme Activation; Glucosephosphate Dehydrogenase; Glutaminase; Glutamine; Glutathione Peroxidase; Hexokinase; Hydrogen Peroxide; Lymphocytes; Macrophages; Male; Malondialdehyde; Neoplasm Transplantation; Rats; Rats, Wistar | 1993 |
Phosphate-dependent glutaminase of rat skeletal muscle. Some properties and possible role in glutamine metabolism.
Topics: Animals; Enzyme Activation; Glutaminase; Glutamine; Humans; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Mitochondria; Muscles; Phosphates; Rats; Reproducibility of Results | 1993 |
Metabolic and functional changes in lymphocytes and macrophages as induced by ageing.
Topics: Aging; Animals; Carcinoma 256, Walker; Citrate (si)-Synthase; Citric Acid Cycle; Energy Metabolism; Glucosephosphate Dehydrogenase; Glutaminase; Glutamine; Glycolysis; Hexokinase; Hydrogen Peroxide; Lymphocyte Activation; Lymphocytes; Macrophages; Male; Neoplasm Transplantation; Pentose Phosphate Pathway; Phagocytosis; Rats | 1993 |
The role of glutaminase in Rhizobium etli: studies with a new mutant.
Topics: Fabaceae; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Mutation; Nitrogen; Phenotype; Plants, Medicinal; Rhizobium; Symbiosis | 1995 |
Probing the mechanism of nitrogen transfer in Escherichia coli asparagine synthetase by using heavy atom isotope effects.
Topics: Aspartate-Ammonia Ligase; Aspartic Acid; Carbon Isotopes; Escherichia coli; Genes, Bacterial; Glutaminase; Glutamine; Isotope Labeling; Kinetics; Models, Chemical; Nitrogen Isotopes; Substrate Specificity | 1996 |
Metabolism of glucose and glutamine in lymphocytes from Graves' hyperthyroid patients: influence of methimazole treatment.
Topics: Adult; Autoantibodies; Carbon Dioxide; Carbon Radioisotopes; Cells, Cultured; Citrate (si)-Synthase; Culture Media; Female; Glucose; Glucosephosphate Dehydrogenase; Glutaminase; Glutamine; Graves Disease; Hexokinase; Humans; Lymphocytes; Male; Methimazole; Middle Aged; Thyroid Function Tests; Thyroid Gland; Thyroxine; Triiodothyronine | 1996 |
Decreased ureagenesis from alanine, but not from ammonia and glutamine, in the perfused rat liver after partial hepatectomy.
Topics: Alanine; Ammonia; Animals; Glutamate Dehydrogenase; Glutaminase; Glutamine; Hepatectomy; Kinetics; Liver; Liver Regeneration; Male; Perfusion; Rats; Rats, Sprague-Dawley; Urea | 1996 |
Reduced glutamine content in colonic polyps.
Topics: Acyltransferases; Adenomatous Polyps; Colonic Polyps; Glutaminase; Glutamine; Humans; Intestinal Mucosa; Precancerous Conditions | 1996 |
Use of intracellular versus extracellular specific activities in calculation of glutamine metabolism in astrocytes: effect of dibutyryl cyclic AMP.
Topics: Animals; Astrocytes; Bucladesine; Cells, Cultured; Culture Media; Extracellular Space; Glutaminase; Glutamine; Intracellular Fluid; Nerve Tissue Proteins; Oxidation-Reduction; Rats | 1996 |
The effect of insulin on macrophage metabolism and function.
Topics: Alloxan; Animals; Cell Count; Citrate (si)-Synthase; Decarboxylation; Diabetes Mellitus, Experimental; Glucose; Glucosephosphate Dehydrogenase; Glutaminase; Glutamine; Hexokinase; Hydrogen Peroxide; Insulin; Lactates; Macrophages, Peritoneal; Male; Mycobacterium bovis; Phagocytosis; Rats; Rats, Wistar; Thioglycolates; Time Factors | 1996 |
Glutamine improves cold-preserved small bowel graft structure and function following ischemia and reperfusion.
Topics: Adenosine; Allopurinol; Animals; Cold Temperature; Glutaminase; Glutamine; Glutathione; Insulin; Intestinal Mucosa; Intestine, Small; Male; Organ Preservation; Organ Preservation Solutions; Raffinose; Rats; Rats, Inbred Lew; Reperfusion Injury; Time Factors; Transplantation, Isogeneic | 1996 |
Regulation of [15N]urea synthesis from [5-15N]glutamine. Role of pH, hormones, and pyruvate.
Topics: Amino Acids; Ammonia; Animals; Citric Acid Cycle; Citrulline; Gas Chromatography-Mass Spectrometry; Glucagon; Glutamates; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Insulin; Liver; Male; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Urea | 1996 |
Parenteral nutrition modifies glucose and glutamine metabolism in rat isolated enterocytes.
Topics: Animals; Blood Glucose; Cell Separation; Energy Intake; Glucose; Glutaminase; Glutamine; Hormones; Ileum; Intestinal Mucosa; Jejunum; Male; Parenteral Nutrition; Rats; Rats, Wistar; Sucrase; Weight Gain | 1997 |
Aspects of glutamine metabolism in human tumour cells.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cell Division; Culture Media; Dose-Response Relationship, Drug; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Humans; Male; Methionine Sulfoximine; Phosphates; Purines; Pyrimidines; Rats; Rats, Wistar; Thymidine; Tritium; Tumor Cells, Cultured | 1997 |
Increased production of extracellular glutamate by the mitochondrial glutaminase following neuronal death.
Topics: 4-Chloromercuribenzenesulfonate; Animals; Cell Compartmentation; Cell Death; Cells, Cultured; Cerebral Cortex; Culture Techniques; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Glutaminase; Glutamine; Mice; Mitochondria; Models, Biological; N-Methylaspartate; Neuroglia; Neurons | 1997 |
Increased glutamine consumption in small intestine epithelial cells during sepsis in rats.
Topics: Animals; Carbon Dioxide; Cell Separation; DNA; Epithelium; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; In Vitro Techniques; Intestinal Mucosa; Jejunum; Male; Rats; Rats, Sprague-Dawley; Sepsis; Thymidine; Transaminases | 1997 |
Identification of two glutaminases in Rhizobium etli.
Topics: Cloning, Molecular; Enzyme Stability; Genes, Bacterial; Genetic Complementation Test; Glutaminase; Glutamine; Hot Temperature; Isoenzymes; Quaternary Ammonium Compounds; Rhizobium; Succinates; Succinic Acid | 1996 |
Glutamine utilization by rat neutrophils.
Topics: Animals; Aspartic Acid; Glutamic Acid; Glutaminase; Glutamine; In Vitro Techniques; Kinetics; Neutrophils; Rats; Rats, Wistar | 1997 |
Enteral branched-chain amino acids increase the specific activity of jejunal glutaminase and reduce jejunal atrophy.
Topics: Amino Acids, Branched-Chain; Animals; Atrophy; Glutaminase; Glutamine; Jejunum; Male; Parenteral Nutrition; Rats; Rats, Wistar; Statistics, Nonparametric | 1997 |
Effect of adrenaline on lymphocyte metabolism and function. A mechanism involving cAMP and hydrogen peroxide.
Topics: Animals; Bucladesine; Cells, Cultured; Citrate (si)-Synthase; Concanavalin A; Cyclic AMP; Epinephrine; Glucose; Glutaminase; Glutamine; Hexokinase; Hydrogen Peroxide; Isoproterenol; Lipopolysaccharides; Lymphocyte Activation; Lymphocytes; Macrophages; Male; Propranolol; Rats; Rats, Wistar | 1997 |
In vivo mutational analysis of highly conserved amino acid residues of the small subunit Cpa1p of the carbamylphosphate synthetase of Saccharomyces cerevisiae.
Topics: Amino Acid Sequence; Ammonia; Ammonium Sulfate; Arginine; Aspartic Acid; Carbon-Nitrogen Ligases; Chromosome Mapping; Cysteine; Gene Expression; Glutaminase; Glutamine; Histidine; Molecular Sequence Data; Mutagenesis, Site-Directed; Plasmids; Proline; Saccharomyces cerevisiae; Sequence Analysis; Sequence Deletion; Transformation, Genetic | 1997 |
Amino acid utilisation and deamination of glutamine and asparagine by Helicobacter pylori.
Topics: Amino Acids; Ammonia; Asparaginase; Asparagine; Culture Media; Diazooxonorleucine; Enzyme Inhibitors; Glutaminase; Glutamine; Helicobacter pylori | 1997 |
Effect of protein malnutrition on the glycolytic and glutaminolytic enzyme activity of rat thymus and mesenteric lymph nodes.
Topics: Animals; Dietary Proteins; Fructose-Bisphosphate Aldolase; Glucose; Glucose-6-Phosphate Isomerase; Glutaminase; Glutamine; Glycolysis; Hexokinase; L-Lactate Dehydrogenase; Lymph Nodes; Male; Phosphofructokinase-1; Protein-Energy Malnutrition; Pyruvate Kinase; Rats; Rats, Wistar; Thymus Gland | 1997 |
Effects of endotoxin on intestinal hemodynamics, glutamine metabolism, and function.
Topics: Animals; Cell Membrane Permeability; Dye Dilution Technique; Endotoxemia; Gastrointestinal Transit; Glutaminase; Glutamine; Hemodynamics; Intestinal Absorption; Intestines; Male; Rats; Rats, Sprague-Dawley; Regional Blood Flow | 1997 |
Soluble and membrane-bound forms of phosphate-activated glutaminase with different kinetic characteristics in pig and rat kidney mitochondria.
Topics: Animals; Cytosol; Detergents; Enzyme Inhibitors; Ethylmaleimide; Glutamic Acid; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Immunoblotting; Kidney; Kinetics; Mitochondria; Octoxynol; Phosphates; Polyethylene Glycols; Rats; Swine | 1997 |
Glutamine utilization by rat neutrophils: presence of phosphate-dependent glutaminase.
Topics: Animals; Blood Glucose; Blotting, Western; Glutaminase; Glutamine; In Vitro Techniques; Kinetics; Male; Neutrophils; Oxygen Consumption; Rats; Rats, Wistar; RNA, Messenger; Transcription, Genetic | 1997 |
Regulation of hepatic glutaminase in the streptozotocin-induced diabetic rat.
Topics: Animals; Carbon Dioxide; Carbon Radioisotopes; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Glutaminase; Glutamine; Kinetics; Liver; Male; Mitochondria, Liver; Rats; Rats, Sprague-Dawley | 1997 |
Gonadectomy impairs lymphocyte proliferation and macrophage function in male and female rats. Correlation with key enzyme activities of glucose and glutamine metabolism.
Topics: Animals; Cell Division; Citrate (si)-Synthase; Citric Acid Cycle; Concanavalin A; Female; Glucose; Glucosephosphate Dehydrogenase; Glutaminase; Glutamine; Gonadal Steroid Hormones; Lipopolysaccharides; Lymphocytes; Macrophages; Male; Orchiectomy; Ovariectomy; Pentose Phosphate Pathway; Rats; Rats, Inbred Strains; Thymidine; Tritium | 1997 |
The effect of melatonin chronic treatment upon macrophage and lymphocyte metabolism and function in Walker-256 tumour-bearing rats.
Topics: Animals; Antioxidants; Carbon Dioxide; Carbon Radioisotopes; Carcinoma 256, Walker; Citrate (si)-Synthase; Citric Acid Cycle; Glucose; Glucosephosphate Dehydrogenase; Glutaminase; Glutamine; Hexokinase; Lymphocytes; Macrophages; Male; Melatonin; Pineal Gland; Rats; Rats, Wistar | 1998 |
Hepatic glutamine transport and metabolism.
Topics: Alkalosis; Ammonia; Biological Transport; Cell Membrane; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Hormones; Humans; Hydrogen-Ion Concentration; Liver; Mitochondria; Models, Biological; Transaminases | 1998 |
Glutamine transport by the blood-brain barrier: a possible mechanism for nitrogen removal.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Brain; Cattle; Cell Membrane; Endothelium, Vascular; Glutamic Acid; Glutaminase; Glutamine; Nitrogen; Sodium | 1998 |
Effects of L-glutamine on post-ischaemic cardiac function: protection and rescue.
Topics: Adenosine Triphosphate; Alanine; Animals; Cardiac Output; Glutamates; Glutaminase; Glutamine; Lactates; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Phosphocreatine; Rats; Rats, Sprague-Dawley; Water | 1998 |
Glutamate transport and cellular glutamine metabolism: regulation in LLC-PK1 vs. LLC-PK1-F+ cell lines.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; ATP-Binding Cassette Transporters; Binding, Competitive; Biological Transport; gamma-Glutamyltransferase; Glutamate Dehydrogenase; Glutamic Acid; Glutaminase; Glutamine; Homeostasis; Ketoglutaric Acids; Kinetics; LLC-PK1 Cells; Quaternary Ammonium Compounds; Swine | 1998 |
Distribution of glutaminase and glutamine synthetase activities in the human gastrointestinal tract.
Topics: Adult; Aged; Digestive System; Esophagus; Gastric Juice; Gastric Mucosa; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Humans; Intestinal Mucosa; Middle Aged; Mucous Membrane | 1998 |
Glutamine metabolism in the gastrointestinal tract of the rat assess by the relative activities of glutaminase (EC 3.5.1.2) and glutamine synthetase (EC 6.3.1.2).
Topics: Animals; Digestive System; Esophagus; Gastric Mucosa; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Intestinal Mucosa; Male; Mouth; Rats; Rats, Inbred Strains; Stomach | 1998 |
Importance of glutamine metabolism in murine macrophages and human monocytes to L-arginine biosynthesis and rates of nitrite or urea production.
Topics: Animals; Arginine; Diazooxonorleucine; Enzyme Inhibitors; Glutaminase; Glutamine; Humans; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Male; Mice; Mice, Inbred Strains; Monocytes; Mycobacterium bovis; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Urea | 1998 |
Macrophage-mediated lysis of a beta-cell line, tumour necrosis factor-alpha release from bacillus Calmette-Guérin (BCG)-activated murine macrophages and interleukin-8 release from human monocytes are dependent on extracellular glutamine concentration and
Topics: Animals; Cell Line; Cells, Cultured; Coculture Techniques; Diazooxonorleucine; Enzyme Inhibitors; Extracellular Space; Glutaminase; Glutamine; Humans; Interleukin-8; Islets of Langerhans; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Male; Mice; Mice, Inbred Strains; Monocytes; Mycobacterium bovis; Tumor Necrosis Factor-alpha | 1999 |
Effect of dietary fat on lymphocyte proliferation and metabolism.
Topics: Animals; Citrate (si)-Synthase; Coconut Oil; Dietary Fats; Energy Metabolism; Fatty Acids, Monounsaturated; Glutaminase; Glutamine; Glycolysis; Hexokinase; Lymphocyte Activation; Lymphoid Tissue; Male; Plant Oils; Rapeseed Oil; Rats; Rats, Wistar; Soybean Oil; Thymus Gland | 1998 |
The function of Glu338 in the catalytic triad of the carbamoyl phosphate synthetase amidotransferase domain.
Topics: Ammonia; Animals; Carbamoyl-Phosphate Synthase (Ammonia); Cells, Cultured; Cricetinae; Escherichia coli; Glutaminase; Glutamine; Kinetics; Mesocricetus; Mutagenesis, Site-Directed; Mutation; Recombinant Fusion Proteins | 1998 |
Formation and isolation of a covalent intermediate during the glutaminase reaction of a class II amidotransferase.
Topics: Aspartate-Ammonia Ligase; Carbon Radioisotopes; Escherichia coli; Glutaminase; Glutamine; Hydroxylamine; Kinetics | 1999 |
Postembedding immunogold labelling reveals subcellular localization and pathway-specific enrichment of phosphate activated glutaminase in rat cerebellum.
Topics: Animals; Cerebellum; Glutamic Acid; Glutaminase; Glutamine; Immunoblotting; Immunohistochemistry; Male; Mitochondria; Rats; Rats, Wistar; Tissue Distribution; Tissue Embedding | 1999 |
Estimation of gene expression within the intestinal mucosa using semiquantitative reverse transcriptase-polymerase chain reaction.
Topics: Animals; Base Sequence; DNA Primers; Evaluation Studies as Topic; Gene Expression; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; In Vitro Techniques; Intestinal Mucosa; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 1999 |
Changes in hepatic nitrogen metabolism in isolated perfused liver during the development of thioacetamide-induced cirrhosis in rats.
Topics: Alanine Transaminase; Ammonia; Animals; Aspartate Aminotransferases; Diet; Female; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Liver; Liver Cirrhosis, Experimental; Nitrogen; Perfusion; Rats; Rats, Sprague-Dawley; Thioacetamide; Time Factors; Urea | 1999 |
Impact of culture conditions, culture media volumes, and glucose content on metabolic properties of renal epithelial cell cultures. Are renal cells in tissue culture hypoxic?
Topics: Animals; Cell Culture Techniques; Cell Hypoxia; Cell Line; Culture Media; Glucose; Glutaminase; Glutamine; Glycolysis; Hexokinase; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Lactates; Opossums; Phosphofructokinase-1; Pyruvate Kinase; Swine; Urothelium | 1999 |
Studies of hepatic glutamine metabolism in the perfused rat liver with (15)N-labeled glutamine.
Topics: Ammonia; Animals; Aspartic Acid; Carbamyl Phosphate; Citrulline; Glucagon; Glutamates; Glutaminase; Glutamine; Insulin; Liver; Male; Nitrogen Isotopes; Oxygen Consumption; Perfusion; Rats; Rats, Sprague-Dawley; Urea | 1999 |
Effect of exposure to dietary nivalenol on activity of enzymes involved in glutamine catabolism in the epithelium along the gastrointestinal tract of growing pigs.
Topics: Alanine Transaminase; Animals; Colon; Digestive System; Gastric Mucosa; Glutamate Dehydrogenase; Glutaminase; Glutamine; Intestinal Mucosa; Intestine, Small; Isocitrate Dehydrogenase; Ketoglutarate Dehydrogenase Complex; Male; Mycotoxins; Specific Pathogen-Free Organisms; Spectrophotometry; Stomach; Swine; Trichothecenes | 1999 |
Angiogenesis a putative new approach in glutamine related therapy.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cervix Uteri; Female; Glutaminase; Glutamine; Liver; Male; Methylcholanthrene; Mice; Neovascularization, Pathologic; Neovascularization, Physiologic; Sarcoma 180; Uterine Cervical Dysplasia | 1999 |
Phosphate activated glutaminase is concentrated in mitochondria of sensory hair cells in rat inner ear: a high resolution immunogold study.
Topics: Animals; Enzyme Activation; Fluorescent Antibody Technique, Indirect; Glutamic Acid; Glutaminase; Glutamine; Hair Cells, Auditory; Immunohistochemistry; Microscopy, Fluorescence; Mitochondria; Nerve Tissue Proteins; Rats; Rats, Wistar; Signal Transduction; Subcellular Fractions | 1999 |
Molecular cloning, sequencing and expression studies of the human breast cancer cell glutaminase.
Topics: Amino Acid Sequence; Base Sequence; Breast Neoplasms; Cloning, Molecular; Escherichia coli; Female; Gene Expression; Gene Library; Glutaminase; Glutamine; Humans; Molecular Sequence Data; Neoplasm Proteins; Recombinant Proteins; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Tissue Distribution | 2000 |
Deconstruction of the catalytic array within the amidotransferase subunit of carbamoyl phosphate synthetase.
Topics: Adenosine Diphosphate; Anthranilate Synthase; Binding Sites; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carbamyl Phosphate; Catalytic Domain; Glutaminase; Glutamine; Kinetics; Mutagenesis, Site-Directed; Mutation; Nitrogenous Group Transferases; Polymerase Chain Reaction | 1999 |
Modulation of glutamine uptake and phosphate-activated glutaminase activity in rat brain mitochondria by amino acids and their synthetic analogues.
Topics: Alanine; Amino Acids; Animals; Brain; Enzyme Activation; Female; Glutaminase; Glutamine; Kinetics; Leucine; Mitochondria; Phosphates; Rats; Rats, Wistar | 2000 |
Glutamine-enriched parenteral nutrition regulates the activity and expression of intestinal glutaminase.
Topics: Animals; Enzyme Activation; Gene Expression Regulation, Enzymologic; Glutaminase; Glutamine; Ileum; In Situ Hybridization; Intestines; Jejunum; Male; Parenteral Nutrition; Rats; Rats, Wistar; RNA, Messenger | 2000 |
Determination of NADH-dependent glutamate synthase (GOGAT) in Spodoptera frugiperda (Sf9) insect cells by a selective 1H/15N NMR in vitro assay.
Topics: Animals; Cell Line; Cell-Free System; Glutamate Synthase; Glutaminase; Glutamine; Ketoglutaric Acids; Magnetic Resonance Spectroscopy; NAD; Nitrogen Isotopes; Quaternary Ammonium Compounds; Spectrophotometry; Spodoptera | 2000 |
A general survey of glutamine level in different tissues of murine solid tumor bearing mice before and after therapy with purified glutaminase.
Topics: Animals; Brain; Carcinoma, Ehrlich Tumor; Glutaminase; Glutamine; Intestinal Mucosa; Kidney; Liver; Male; Methylcholanthrene; Mice; Sarcoma 180; Skin Neoplasms; Spleen; Tissue Distribution | 2000 |
Neither glutamine nor arginine supplementation of diets increase glutamine body stores in healthy growing rats.
Topics: Amino Acids; Animals; Arginine; Dietary Supplements; Down-Regulation; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Intestinal Mucosa; Liver; Male; Muscles; Proteins; Rats; Rats, Wistar | 2000 |
Subunit interactions and glutamine utilization by Escherichia coli imidazole glycerol phosphate synthase.
Topics: Amino Acid Sequence; Aminohydrolases; Ammonia; Cloning, Molecular; Conserved Sequence; Escherichia coli; Glutaminase; Glutamine; Hydrolysis; Kinetics; Molecular Sequence Data; Mutagenesis; Mutation; Protein Binding; Protein Subunits; Selection, Genetic; Sequence Homology, Amino Acid | 2001 |
Neovascularisation offers a new perspective to glutamine related therapy.
Topics: Angiogenesis Inhibitors; Animals; Carcinogens; Carcinoma, Ehrlich Tumor; Drug Screening Assays, Antitumor; Glutaminase; Glutamine; Injections, Intraperitoneal; Male; Methylcholanthrene; Mice; Neoplasm Proteins; Neoplasms, Experimental; Neovascularization, Pathologic; Sarcoma 180 | 2000 |
Glutamine utilization in activated lymphocytes from rats receiving endotoxin.
Topics: Animals; Cell Division; Concanavalin A; Endotoxins; Glutaminase; Glutamine; Lymphocytes; Male; Osmolar Concentration; Rats; Rats, Wistar; Stress, Physiological | 2001 |
Regulation of mitochondrial glutamine/glutamate metabolism by glutamate transport: studies with (15)N.
Topics: Ammonia; Animals; Aspartic Acid; Cell Line; Cytosol; Extracellular Space; Glutamate Dehydrogenase; Glutamic Acid; Glutaminase; Glutamine; Intracellular Fluid; Kidney Tubules, Proximal; Kinetics; Mitochondria; Models, Chemical; Nitrogen Isotopes; Stereoisomerism | 2001 |
Does glutamine act as a substrate for transamination reactions in the liver of fed and fasted sheep?
Topics: Analysis of Variance; Animals; Cross-Over Studies; Fasting; Gas Chromatography-Mass Spectrometry; Glutaminase; Glutamine; Liver; Methionine; Nitrogen Isotopes; Phenylalanine; Proteins; Sheep | 2001 |
Mechanisms governing the expression of the enzymes of glutamine metabolism--glutaminase and glutamine synthetase.
Topics: Animals; Cell Line; Dexamethasone; Gene Expression Regulation, Enzymologic; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Homeostasis; Protein Biosynthesis; Pulmonary Alveoli; Rats; RNA, Messenger | 2001 |
Channeling of ammonia in glucosamine-6-phosphate synthase.
Topics: Ammonia; Binding Sites; Catalysis; Crystallography, X-Ray; Dimerization; Escherichia coli; Glutaminase; Glutamine; Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); Isomerases; Models, Molecular; Multienzyme Complexes; Nitrogen; Protein Structure, Quaternary; Protein Structure, Tertiary; Solvents; Structure-Activity Relationship | 2001 |
Isolation of a novel, phosphate-activated glutaminase from Bacillus pasteurii.
Topics: Bacillus; Culture Media; Enzyme Activation; Glutaminase; Glutamine; Phosphates; Substrate Specificity | 2002 |
Analysis of taste-active compounds in an enzymatic hydrolysate of deamidated wheat gluten.
Topics: Adult; Chemical Fractionation; Chromatography, Gel; Chromatography, High Pressure Liquid; Endopeptidases; Glutamic Acid; Glutaminase; Glutamine; Glutens; Humans; Hydrolysis; Middle Aged; Oligopeptides; Taste; Triticum | 2002 |
Evidence that glutamine is involved in neutrophil function.
Topics: Animals; Glutaminase; Glutamine; Glycogen; Lipopolysaccharides; Male; Neutrophils; Nitric Oxide; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2002 |
Mutagenesis and mechanism-based inhibition of Streptococcus pyogenes Glu-tRNAGln amidotransferase implicate a serine-based glutaminase site.
Topics: Alanine; Amides; Amino Acid Sequence; Aminoacyltransferases; Binding Sites; Binding, Competitive; Boronic Acids; Conserved Sequence; Glutaminase; Glutamine; Hydrolysis; Molecular Sequence Data; Mutagenesis, Site-Directed; Nitrogenous Group Transferases; Serine; Streptococcus pyogenes | 2002 |
The effect of sub-lethal ammonia exposure on fed and unfed rainbow trout: the role of glutamine in regulation of ammonia.
Topics: Ammonia; Animals; Brain; Food Deprivation; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Hydrocortisone; Hydrogen-Ion Concentration; Liver; Muscles; Oncorhynchus mykiss; Postprandial Period; Temperature; Time Factors | 2002 |
Properties of the recombinant ferredoxin-dependent glutamate synthase of Synechocystis PCC6803. Comparison with the Azospirillum brasilense NADPH-dependent enzyme and its isolated alpha subunit.
Topics: Amino Acid Oxidoreductases; Azospirillum brasilense; Catalysis; Cyanobacteria; Dithionite; Ferredoxins; Glutamic Acid; Glutaminase; Glutamine; Ketoglutaric Acids; NADP; Oxidation-Reduction; Recombinant Proteins; Spectrometry, Fluorescence; Spectrophotometry; Sulfites; Tetrazolium Salts; Titrimetry | 2002 |
Sub-lethal concentrations of activated complement increase rat lymphocyte glutamine utilization and oxidation while lethal concentrations cause death by a mechanism involving ATP depletion.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Cell Death; Cell Survival; Complement System Proteins; Dose-Response Relationship, Drug; Glucose; Glucosephosphate Dehydrogenase; Glutaminase; Glutamine; Hexokinase; Humans; Lymphocytes; Male; Necrosis; Oxygen; Pentose Phosphate Pathway; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar | 2002 |
Localization and possible function of the glutamate transporter, EAAC1, in the rat retina.
Topics: Amacrine Cells; Amino Acid Transport System X-AG; Amino Acids; Animals; Enzyme Inhibitors; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 3; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Glutaminase; Glutamine; Immunohistochemistry; Microscopy, Electron; Neural Inhibition; Neural Pathways; Presynaptic Terminals; Rats; Retina; Retinal Ganglion Cells; Symporters; Synaptic Membranes; Synaptic Transmission | 2002 |
Steady-state kinetics of the glutaminase reaction of CTP synthase from Lactococcus lactis. The role of the allosteric activator GTP incoupling between glutamine hydrolysis and CTP synthesis.
Topics: Allosteric Regulation; Calorimetry; Carbon-Nitrogen Ligases; Cytidine Triphosphate; Glutaminase; Glutamine; Guanosine Triphosphate; Hydrolysis; Kinetics; Lactococcus lactis; Models, Biological | 2002 |
Structure of imidazole glycerol phosphate synthase from Thermus thermophilus HB8: open-closed conformational change and ammonia tunneling.
Topics: Aminohydrolases; Ammonia; Catalytic Domain; Crystallography, X-Ray; Glutaminase; Glutamine; Protein Conformation; Protein Structure, Tertiary; Thermus thermophilus | 2002 |
An assay for cytidine 5(')-triphosphate synthetase glutaminase activity using high performance liquid chromatography.
Topics: Adenosine Triphosphate; Carbon-Nitrogen Ligases; Chromatography, High Pressure Liquid; Colorimetry; Cytidine Triphosphate; Glutaminase; Glutamine; Guanosine Triphosphate; Kinetics; Mutation; Uridine Triphosphate | 2002 |
Limited proteolysis of Escherichia coli cytidine 5'-triphosphate synthase. Identification of residues required for CTP formation and GTP-dependent activation of glutamine hydrolysis.
Topics: Amino Acid Sequence; Arginine; Binding Sites; Carbon-Nitrogen Ligases; Catalysis; Circular Dichroism; Cytidine Triphosphate; Dimerization; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Escherichia coli; Glutaminase; Glutamine; Guanosine Triphosphate; Hydrolysis; Kinetics; Lysine; Models, Chemical; Models, Genetic; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Plasmids; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Proteins; Sequence Homology, Amino Acid; Time Factors; Trypsin | 2003 |
Phosphate-dependent glutaminase in enterocyte mitochondria and its regulation by ammonium and other ions.
Topics: Animals; Bicarbonates; Enterocytes; Glutaminase; Glutamine; In Vitro Techniques; Ions; Male; Mitochondria; Phosphates; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Sulfates | 2003 |
Bacterial expression, purification, and characterization of rat kidney-type mitochondrial glutaminase.
Topics: Animals; Blotting, Western; Chromatography, Affinity; Chromatography, Gel; Cloning, Molecular; DNA, Complementary; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Escherichia coli; Exons; Gene Deletion; Gene Expression; Genetic Vectors; Glutamate Dehydrogenase; Glutaminase; Glutamine; Histidine; Isopropyl Thiogalactoside; Kinetics; Mitochondria; Oligopeptides; Phosphates; Polymerase Chain Reaction; Protein Binding; Protein Structure, Quaternary; Rats; Recombinant Proteins; Sonication | 2003 |
Enteral alanyl-glutamine supplement promotes intestinal adaptation in rats.
Topics: Alanine; Animals; Blotting, Northern; Dipeptides; Glutaminase; Glutamine; Intestine, Small; Intestines; Male; Peptides; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors | 2003 |
Glutamate transport, glutamine synthetase and phosphate-activated glutaminase in rat CNS white matter. A quantitative study.
Topics: Animals; Biological Transport; Biomarkers; Brain; Brain Chemistry; Central Nervous System; Enzyme Activation; Excitatory Amino Acid Transporter 2; Fornix, Brain; Glucose; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Male; Medulla Oblongata; Optic Nerve; Proteolipids; Rats; Rats, Wistar; Trigeminal Nerve | 2003 |
Renal glutaminase in adrenalectomized and in hypophysectomized rats, and plasma glutamine levels in normal and adrenalectomized rats.
Topics: Adrenal Glands; Amidohydrolases; Animals; Blood; Glutaminase; Glutamine; Kidney; Pituitary Gland; Rats | 1953 |
Glutamine and glutaminase in blood.
Topics: Amidohydrolases; Glutaminase; Glutamine; Humans | 1956 |
Kidney glutaminases. II. The glutamine-alpha-keto acid transamination-deamidation system of the guinea pig.
Topics: Amidohydrolases; Amination; Glutaminase; Glutamine; Guinea Pigs; Keto Acids; Kidney | 1957 |
Kidney glutaminases. III. Glutamine synthesis in the guinea pig kidney.
Topics: Amidohydrolases; Biochemical Phenomena; Glutaminase; Glutamine; Guinea Pigs; Kidney | 1957 |
Kidney glutaminases. IV. Identity of the non-phosphateactivated glutaminase with the glutamine synthesizing enzyme system.
Topics: Amidohydrolases; Biochemical Phenomena; Glutaminase; Glutamine; Humans; Kidney | 1957 |
AN ENZYMIC MICROMETHOD FOR DETERMINATION OF GLUTAMINE AND ASPARAGINE IN BLOOD.
Topics: Amidohydrolases; Animals; Asparagine; Blood Chemical Analysis; Colorimetry; Glutaminase; Glutamine; Guinea Pigs; Microchemistry; Pseudomonas; Rabbits; Rats; Research | 1963 |
EFFECT OF MOLYBDENUM AND TUNGSTEN IONS ON INTERMEDIATE METABOLISM OF GLUTAMINE IN RAT LIVER AND BRAIN.
Topics: Brain; Glutaminase; Glutamine; Ions; Liver; Molybdenum; Proteins; Rats; Research; Toxicology; Tungsten | 1963 |
ENZYMATIC SYNTHESIS OF GAMMA-GLUTAMYLHYDROXAMIC ACID FROM GLUTAMIC ACID AND HYDROXYLAMINE.
Topics: Amidohydrolases; Ammonia; Antimetabolites; Asparagine; Azaserine; Azotobacter; Carbon Isotopes; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Hydroxamic Acids; Hydroxylamine; Hydroxylamines; Pharmacology; Proteins; Research; Streptomycin | 1963 |
[GLUTAMINE METABOLISM ENZYMES IN THE HEART MUSCLE].
Topics: Animals; Birds; Cats; Glutaminase; Glutamine; Ligases; Liver; Metabolism; Muscles; Myocardium; Physiology, Comparative; Rabbits; Rats; Research; Transferases | 1963 |
[GLUTAMINE CONTENT AND GLUTAMINE METABOLIC ENZYMES IN THE HEART IN DISORDERS OF ITS CIRCULATION].
Topics: Acyltransferases; Amino Acids; Ammonia; Animals; Coronary Disease; Glutaminase; Glutamine; Heart; Humans; Ligases; Myocardium; Nitrogen; Posture; Rabbits; Research | 1963 |
EFFECT OF CERTAIN HYDRAZINO-PEPTIDES ON GLUTAMINE METABOLISM IN BRAIN.
Topics: Amino Acids; Brain; Glutaminase; Glutamine; Hydrazines; Mitochondria; Peptides; Pharmacology; Rats; Research | 1964 |
GLUTAMINE SYNTHETASE, GLUTAMOTRANSFERASE, AND GLUTAMINASE IN NEURONS AND NON-NEURAL TISSUE IN THE MEDICAL GENICULATE BODY OF THE CAT.
Topics: Brain; Cats; Geniculate Bodies; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Histocytochemistry; Ligases; Neurons; Research; Transferases | 1964 |
AMMONIA EXCRETION IN THE EOTENOUS NEWT, NECTURUS MACULOSUS (RAFINESQUE).
Topics: Ammonia; Animals; Body Fluids; Chemical Phenomena; Chemistry; Fluids and Secretions; Glutamate Dehydrogenase; Glutaminase; Glutamine; Kidney; Liver; Metabolism; Necturus maculosus; Nitrogen; Research; Salamandridae; Skin; Urea; Urine; Urodela | 1964 |
PURIFICATION AND PROPERTIES OF GLUTAMINASE AND ASPARAGINASE FROM A PSEUDOMONAD. I. PURIFICATION AND PHYSICAL CHEMICAL PROPERTIES.
Topics: Amidohydrolases; Asparaginase; Biochemical Phenomena; Biochemistry; Chemistry Techniques, Analytical; Chromatography; Electrophoresis; Glutaminase; Glutamine; Molecular Weight; Pseudomonas; Research | 1964 |
RELATIONSHIP OF PNH3 OF TUBULAR CELLS TO RENAL PRODUCTION OF AMMONIA.
Topics: Acidosis; Alanine; Amino Acids; Ammonia; Ammonium Chloride; Animals; Aspartic Acid; Body Fluids; Dogs; Fluids and Secretions; Glomerular Filtration Rate; Glutamates; Glutaminase; Glutamine; Glycine; Kidney; Kidney Tubules; Lactates; p-Aminohippuric Acid; Physiology; Research; Serine; Urine | 1965 |
RENAL HYPERTROPHY IN METABOLIC ACIDOSIS AND ITS RELATION TO AMMONIA EXCRETION.
Topics: Acidosis; Ammonia; Ammonium Chloride; Biochemical Phenomena; Biochemistry; DNA; Fluids and Secretions; Glutaminase; Glutamine; Hypertrophy; Ketoglutaric Acids; Kidney; Metabolism; Nephrectomy; Physiology; Rats; Research; RNA; Urine | 1965 |
EFFECT OF DIETARY PROTEIN CONTENT ON VISUAL DISCRIMINATION LEARNING AND BRAIN BIOCHEMISTRY IN THE ALBINO RAT.
Topics: Acyltransferases; Alanine; Alanine Transaminase; Amino Acid Oxidoreductases; Aminobutyrates; Aspartate Aminotransferases; Aspartic Acid; Brain; Brain Chemistry; Carboxy-Lyases; Dietary Proteins; Discrimination Learning; Glutamate Dehydrogenase; Glutaminase; Glutamine; Ketoglutaric Acids; Ligases; Protein Deficiency; Rats; Research; Transaminases | 1965 |
Identification of Pseudomonas proteins coordinately induced by acidic amino acids and their amides: a two-dimensional electrophoresis study.
Topics: Asparaginase; Asparagine; Aspartic Acid; Bacterial Proteins; Glutamic Acid; Glutaminase; Glutamine; Periplasm; Proteomics; Pseudomonas fluorescens; Pseudomonas putida; Reverse Transcriptase Polymerase Chain Reaction; Sigma Factor | 2003 |
Induction of control genes in intestinal gluconeogenesis is sequential during fasting and maximal in diabetes.
Topics: Animals; Diabetes Mellitus; Enzyme Activation; Fasting; Gene Expression Regulation, Enzymologic; Gluconeogenesis; Glucose; Glucose-6-Phosphatase; Glutaminase; Glutamine; Glycerol; Glycerol Kinase; Intestine, Small; Male; Metabolic Clearance Rate; Phosphoenolpyruvate Carboxykinase (ATP); Rats; Rats, Sprague-Dawley; Tissue Distribution | 2004 |
Mitochondrial glutaminase enhances extracellular glutamate production in HIV-1-infected macrophages: linkage to HIV-1 associated dementia.
Topics: AIDS Dementia Complex; Anti-HIV Agents; Cell Survival; Cells, Cultured; Chromatography, High Pressure Liquid; Culture Media, Conditioned; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Space; Glutamic Acid; Glutaminase; Glutamine; HIV Infections; HIV-1; Humans; Macrophages; Mitochondria; Monocytes; RNA, Messenger; Zidovudine | 2004 |
Granule localization of glutaminase in human neutrophils and the consequence of glutamine utilization for neutrophil activity.
Topics: Cytoplasmic Granules; Glutaminase; Glutamine; Humans; Immunohistochemistry; Microscopy, Confocal; Neutrophil Activation; Neutrophils; Oxidation-Reduction; Respiratory Burst | 2004 |
Glutamine synthesis in the developing porcine placenta.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Alanine; Alanine Transaminase; Amino Acids; Amino Acids, Branched-Chain; Animals; Biological Transport; Female; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Placenta; Placentation; Pregnancy; Swine; Transaminases | 2004 |
Characterization of the products of the genes SNO1 and SNZ1 involved in pyridoxine synthesis in Saccharomyces cerevisiae.
Topics: Chromosome Mapping; Chromosomes, Fungal; Diazooxonorleucine; DNA Primers; Enzyme Inhibitors; Escherichia coli; Glutamic Acid; Glutaminase; Glutamine; Hydrolysis; Kinetics; Mutation; Plasmids; Pyridoxine; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2004 |
Role of glutaminase in the production of urinary ammonia.
Topics: Ammonia; Enzymes; Glutaminase; Glutamine; Humans | 1951 |
Inhibition of E. coli CTP synthase by the "positive" allosteric effector GTP.
Topics: Allosteric Regulation; Ammonia; Carbon-Nitrogen Ligases; Cytidine Triphosphate; Escherichia coli; Glutaminase; Glutamine; Guanosine Triphosphate; Hydrolysis; Kinetics; Uridine Triphosphate | 2004 |
Enterocyte metabolism during early adaptation after extensive intestinal resection in a rat model.
Topics: Adaptation, Physiological; Animals; Arginine; Arteries; Body Weight; Cell Separation; Citrulline; Decarboxylation; Enterocytes; Glutaminase; Glutamine; Glutathione; Intestine, Small; Intestines; Male; Ornithine; Ornithine Decarboxylase; Rats; Rats, Wistar | 2004 |
In vivo neuroprotective adaptation of the glutamate/glutamine cycle to neuronal death.
Topics: Animals; Apoptosis; Brain; Brain Injuries; Cell Death; Cell Survival; Denervation; Disease Models, Animal; Energy Metabolism; Fornix, Brain; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Hippocampus; L-Lactate Dehydrogenase; Lactic Acid; Male; Necrosis; Nerve Degeneration; Neurons; Neurotoxins; Rats; Rats, Sprague-Dawley | 2004 |
Gln-tRNAGln formation from Glu-tRNAGln requires cooperation of an asparaginase and a Glu-tRNAGln kinase.
Topics: Adenosine Triphosphate; Ammonium Chloride; Archaea; Asparaginase; Aspartic Acid; Binding Sites; Chromatography, Thin Layer; Cloning, Molecular; Enzyme Activation; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Hydrolysis; Lysine; Methanobacteriaceae; Models, Chemical; Mutation; Phosphorylation; Protein Biosynthesis; Protein Kinases; Pyrrolidonecarboxylic Acid; RNA, Transfer; RNA, Transfer, Gln; Threonine | 2005 |
Cerebral glutamate metabolism in Parkinson's disease: an in vivo dynamic (13)C NMS study in the rat.
Topics: Animals; Antiparkinson Agents; Basal Ganglia; Carbon Isotopes; Disease Models, Animal; Dopamine; Glutamic Acid; Glutaminase; Glutamine; Infusions, Intravenous; Levodopa; Lipid Metabolism; Magnetic Resonance Spectroscopy; Male; Neostriatum; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Sodium Acetate | 2005 |
Modulation of tumor induced angiogenesis in Ehrlich ascites tumor.
Topics: Animals; Antineoplastic Agents; Body Weight; Carcinoma, Ehrlich Tumor; Cell Line, Tumor; Cell Proliferation; Diazooxonorleucine; Dose-Response Relationship, Drug; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Mice; Neoplasm Transplantation; Neoplasms; Neovascularization, Pathologic; Ovarian Neoplasms; Time Factors; Vascular Endothelial Growth Factor A | 2004 |
Glutamine metabolism in uricotelic species: variation in skeletal muscle glutamine synthetase, glutaminase, glutamine levels and rates of protein synthesis.
Topics: Animals; Chickens; Columbidae; Female; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Liver; Lizards; Male; Muscle Proteins; Muscle, Skeletal; Species Specificity | 2005 |
Cultures of rat astrocytes challenged with a steady supply of glutamate: new model to study flux distribution in the glutamate-glutamine cycle.
Topics: Animals; Astrocytes; Cell Communication; Cells, Cultured; Central Nervous System; Energy Metabolism; Enzyme Inhibitors; Ethanolamines; Extracellular Fluid; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Neurons; Phosphocreatine; Phosphorylcholine; Rats; Rats, Wistar; Stress, Physiological; Synaptic Transmission; Transaminases; Up-Regulation | 2005 |
Effect of glaucoma on the retinal glutamate/glutamine cycle activity.
Topics: Animals; Glaucoma; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Hyaluronic Acid; Intraocular Pressure; Male; Melatonin; Rats; Rats, Wistar; Retina | 2005 |
A new arrangement of (beta/alpha)8 barrels in the synthase subunit of PLP synthase.
Topics: Ammonia; Bacillus subtilis; Base Sequence; Binding Sites; Catalysis; Cloning, Molecular; Crystallography, X-Ray; Escherichia coli; Glutaminase; Glutamine; Glycols; Models, Chemical; Models, Molecular; Models, Statistical; Molecular Sequence Data; Nitrogenous Group Transferases; Phosphorylation; Plasmids; Protein Binding; Protein Conformation; Protein Folding; Protein Structure, Quaternary; Protein Structure, Secondary; Protein Structure, Tertiary; Pyridoxal Phosphate; Ribulosephosphates; Substrate Specificity | 2005 |
Role of glutamine and neuronal glutamate uptake in glutamate homeostasis and synthesis during vesicular release in cultured glutamatergic neurons.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; Brain; Cells, Cultured; Citric Acid Cycle; Dicarboxylic Acids; Excitatory Postsynaptic Potentials; Glutamic Acid; Glutaminase; Glutamine; Homeostasis; Mice; Mitochondria; Neurons; Potassium; Presynaptic Terminals; Pyrrolidines; Synaptic Transmission; Synaptic Vesicles | 2005 |
Enhancement of glutamine utilization in Bacillus subtilis through the GlnK-GlnL two-component regulatory system.
Topics: Bacillus subtilis; Bacterial Proteins; Base Sequence; beta-Galactosidase; Carrier Proteins; DNA Primers; Genes, Reporter; Genotype; Glutaminase; Glutamine; Histidine Kinase; Kinetics; Molecular Sequence Data; Protein Kinases; Trans-Activators | 2005 |
Formation of extracellular glutamate from glutamine: exclusion of pyroglutamate as an intermediate.
Topics: Animals; Carbon Isotopes; Chromatography, High Pressure Liquid; Dialysis; Extracellular Space; Glutamic Acid; Glutaminase; Glutamine; Hippocampus; Male; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Time Factors | 2005 |
Characterization of salt-tolerant glutaminase from Stenotrophomonas maltophilia NYW-81 and its application in Japanese soy sauce fermentation.
Topics: Amino Acid Sequence; Asparagine; Aspergillus oryzae; Chromatography, Gel; DNA, Bacterial; DNA, Ribosomal; Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Escherichia coli; Fermentation; Glutamic Acid; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Micrococcus luteus; Molecular Sequence Data; Molecular Weight; Pseudomonas; Saline Solution, Hypertonic; Soy Foods; Stenotrophomonas maltophilia; Substrate Specificity; Temperature | 2005 |
On the two components of pyridoxal 5'-phosphate synthase from Bacillus subtilis.
Topics: Antioxidants; Bacillus subtilis; Binding Sites; Carbon-Nitrogen Lyases; Chromatography; Chromatography, Gel; Chromatography, High Pressure Liquid; Cloning, Molecular; Cysteine; DNA; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Escherichia coli Proteins; Glutaminase; Glutamine; Immunochemistry; Isoxazoles; Kinetics; Mass Spectrometry; Models, Chemical; Organophosphates; Oxidoreductases; Pentosephosphates; Protein Structure, Tertiary; Pyridoxal Phosphate; Quaternary Ammonium Compounds; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry; Threonine; Time Factors; Ultraviolet Rays; Vitamin B 6 | 2005 |
Reaction coupling through interdomain contacts in imidazole glycerol phosphate synthase.
Topics: Aminohydrolases; Binding Sites; Crystallography, X-Ray; Enzyme Stability; Glutaminase; Glutamine; Hydrolysis; Kinetics; Models, Molecular; Mutation; Protein Binding; Protein Structure, Tertiary; Saccharomyces cerevisiae; Transaminases | 2005 |
[Effects of glutamine on the intestinal failure in rats model of acute necrotizing pancreatitis].
Topics: Animals; Apoptosis; Down-Regulation; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Insulin-Like Growth Factor I; Intestinal Mucosa; Male; Pancreatitis, Acute Necrotizing; Random Allocation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Up-Regulation | 2001 |
Glutamine binding opens the ammonia channel and activates glucosamine-6P synthase.
Topics: Ammonia; Binding Sites; Enzyme Activation; Glutaminase; Glutamine; Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) | 2006 |
Diabetes causes marked changes in function and metabolism of rat neutrophils.
Topics: Animals; Blood Glucose; Cells, Cultured; Citrate (si)-Synthase; Diabetes Mellitus, Experimental; Glucose; Glucosephosphate Dehydrogenase; Glutaminase; Glutamine; Hydrogen Peroxide; Hypoglycemic Agents; Insulin, Isophane; Isocitrate Dehydrogenase; Leukocyte Count; Male; Neutrophils; Palmitic Acid; Phagocytosis; Phosphofructokinases; Rats; Rats, Wistar; Weight Gain | 2006 |
Ammonia channel couples glutaminase with transamidase reactions in GatCAB.
Topics: Adenosine Diphosphate; Amino Acid Sequence; Aminoacyltransferases; Ammonia; Apoenzymes; Asparagine; Base Pairing; Catalytic Domain; Crystallography, X-Ray; Glutaminase; Glutamine; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Magnesium; Manganese; Models, Molecular; Molecular Sequence Data; Mutation; Nucleic Acid Conformation; Protein Structure, Quaternary; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Subunits; RNA, Bacterial; RNA, Transfer, Amino Acyl; RNA, Transfer, Gln; Staphylococcus aureus | 2006 |
Low intestinal glutamine level and low glutaminase activity in Crohn's disease: a rational for glutamine supplementation?
Topics: Adult; Animals; Case-Control Studies; Colon; Crohn Disease; Dietary Supplements; Disease Models, Animal; Enteral Nutrition; Female; Glutaminase; Glutamine; Glutathione; Humans; Ileitis; Ileum; Indomethacin; Intestinal Mucosa; Lipid Peroxidation; Male; Middle Aged; Rats; Rats, Sprague-Dawley; Rectus Abdominis | 2006 |
Characterization of several amino acid transports and glutamine metabolism in MOLT4 human T4 leukemia cells.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Alanine; Amino Acid Transport System ASC; Biological Transport; CD4-Positive T-Lymphocytes; Cell Line, Tumor; Glutaminase; Glutamine; Humans; Kinetics; Leukemia, Lymphoid | 2006 |
Structure of a bacterial pyridoxal 5'-phosphate synthase complex.
Topics: Bacillus subtilis; Glutaminase; Glutamine; Models, Molecular; Multiprotein Complexes; Mutagenesis; Pyridoxal Phosphate | 2006 |
Reaction mechanism of pyridoxal 5'-phosphate synthase. Detection of an enzyme-bound chromophoric intermediate.
Topics: Bacillus subtilis; Bacterial Proteins; Glutaminase; Glutamine; Ligases; Protein Subunits; Ribosemonophosphates; Substrate Specificity; Trioses; Vitamin B 6 | 2007 |
Expression of functional human glutaminase in baculovirus system: affinity purification, kinetic and molecular characterization.
Topics: Ammonia; Animals; Baculoviridae; Catalysis; Cell Line; Cell Nucleus; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation, Enzymologic; Genetic Vectors; Glutamic Acid; Glutaminase; Glutamine; Humans; Isoenzymes; Kinetics; Mitochondria; Recombinant Proteins; Spodoptera; Transfection | 2007 |
High-affinity glycine and glutamate transport in pig forebrain white and gray matter: a quantitative study.
Topics: Animals; Biological Transport; Excitatory Amino Acid Transporter 2; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Glutathione; Glycine; Glycine Hydroxymethyltransferase; Glycine Plasma Membrane Transport Proteins; Kainic Acid; Prosencephalon; Sarcosine; Serine; Swine | 2007 |
Antisense glutaminase inhibition modifies the O-GlcNAc pattern and flux through the hexosamine pathway in breast cancer cells.
Topics: Animals; Breast Neoplasms; Gene Expression; Glutaminase; Glutamine; Hexosamines; Humans; Mice; N-Acetylglucosaminyltransferases; Protein Processing, Post-Translational; Proteomics; RNA Interference; Sp1 Transcription Factor; Tumor Cells, Cultured; Uridine Diphosphate N-Acetylglucosamine | 2008 |
Metabolism of [U-13C]glutamine and [U-13C]glutamate in isolated rat brain mitochondria suggests functional phosphate-activated glutaminase activity in matrix.
Topics: Animals; Brain; Carbon Isotopes; Enzyme Activation; Female; Glutamic Acid; Glutaminase; Glutamine; Mitochondria; Phosphates; Rats; Rats, Wistar | 2008 |
Glutamine deamidation by cereal-associated lactic acid bacteria.
Topics: Bread; Culture Media; Fermentation; Flour; Food Microbiology; Glutamic Acid; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Lactobacillus; Taste; Triticum | 2007 |
Characterisation of glutamine fructose-6-phosphate amidotransferase (EC 2.6.1.16) and N-acetylglucosamine metabolism in Bifidobacterium.
Topics: Acetylglucosamine; Amino Acid Sequence; Bacterial Proteins; Bifidobacterium; Catalytic Domain; Cloning, Molecular; Conserved Sequence; Enzyme Stability; Escherichia coli; Fructosephosphates; Gene Expression; Glucosamine; Glucose-6-Phosphate; Glutamic Acid; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Metabolic Networks and Pathways; Models, Biological; Molecular Sequence Data; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Temperature | 2008 |
Structural and thermodynamic insights into the assembly of the heteromeric pyridoxal phosphate synthase from Plasmodium falciparum.
Topics: Animals; Calorimetry; Crystallography, X-Ray; Glutaminase; Glutamine; Kinetics; Plasmodium falciparum; Protein Conformation; Recombinant Proteins; Substrate Specificity; Thermodynamics | 2007 |
Production of glutaminase (E.C.3.2.1.5) from Zygosaccharomyces rouxii: statistical optimization using response surface methodology.
Topics: Analysis of Variance; Biomass; Bioreactors; Biotechnology; Culture Media; Fermentation; Glutaminase; Glutamine; Models, Chemical; Models, Statistical; Sodium Chloride; Sucrose; Surface Properties; Time Factors; Zygosaccharomyces | 2008 |
Glutamine as a precursor for transmitter glutamate, aspartate and GABA in the cerebellum: a role for phosphate-activated glutaminase.
Topics: Animals; Aspartic Acid; Cerebellum; gamma-Aminobutyric Acid; Glutamic Acid; Glutaminase; Glutamine; Nerve Fibers; Neurotransmitter Agents; Rats; Rats, Wistar | 2008 |
HIV-infected macrophages mediate neuronal apoptosis through mitochondrial glutaminase.
Topics: AIDS Dementia Complex; Animals; Apoptosis; Brain; Caspases; Cell Cycle; Cells, Cultured; Culture Media, Conditioned; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Glutaminase; Glutamine; Humans; Macrophages; Mitochondria; Monocytes; Nerve Degeneration; Neurons; Neurotoxins; Rats | 2008 |
Effects of anterior pituitary growth hormone preparations on the glutamine-glutaminase system.
Topics: Glutaminase; Glutamine; Growth Hormone; Humans; Pituitary Diseases; Pituitary Gland; Pituitary Hormones | 1949 |
Mechanistic studies on pyridoxal phosphate synthase: the reaction pathway leading to a chromophoric intermediate.
Topics: Escherichia coli; Glutaminase; Glutamine; Pyridoxal Phosphate; Ribosemonophosphates | 2008 |
Functional and structural characterization of four glutaminases from Escherichia coli and Bacillus subtilis.
Topics: Amino Acid Sequence; Bacillus subtilis; Bacterial Proteins; Cloning, Molecular; Crystallography, X-Ray; Escherichia coli; Glutaminase; Glutamine; Kinetics; Models, Chemical; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Sequence Homology, Amino Acid | 2008 |
Glutamine affects glutathione recycling enzymes in a DMBA-induced breast cancer model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinogens; Diet; Female; gamma-Glutamyltransferase; Glutamate-Cysteine Ligase; Glutaminase; Glutamine; Glutathione; Intestinal Mucosa; Mammary Neoplasms, Animal; Pyroglutamate Hydrolase; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2008 |
13C MR spectroscopy measurements of glutaminase activity in human hepatocellular carcinoma cells using hyperpolarized 13C-labeled glutamine.
Topics: Biomarkers, Tumor; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Line, Tumor; Diagnosis, Computer-Assisted; Enzyme Activation; Glutaminase; Glutamine; Humans; Liver Neoplasms; Magnetic Resonance Spectroscopy; Neoplasm Proteins | 2008 |
Acivicin with glutaminase regulates proliferation and invasion of human MCF-7 and OAW-42 cells--an in vitro study.
Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Collagen; Drug Combinations; Female; Glutaminase; Glutamine; Humans; In Vitro Techniques; Isoxazoles; Laminin; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Ovarian Neoplasms; Proteoglycans; Tetrazolium Salts; Thiazoles; Vascular Endothelial Growth Factor A | 2008 |
Expression of PPARgamma is reduced by medium supplementation with L-glutamine in human colorectal Caco-2 cells.
Topics: Blotting, Western; Caco-2 Cells; Cell Differentiation; Colon; Culture Media; Cytoplasm; Electrophoretic Mobility Shift Assay; Glutaminase; Glutamine; Humans; Immunohistochemistry; PPAR gamma; Reverse Transcriptase Polymerase Chain Reaction | 2008 |
Transfection with liver-type glutaminase cDNA alters gene expression and reduces survival, migration and proliferation of T98G glioma cells.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; DNA, Complementary; Gene Expression Regulation, Neoplastic; Glioma; Glutamic Acid; Glutaminase; Glutamine; Humans; Isoenzymes; Microarray Analysis; Mitochondria; Polymerase Chain Reaction; RNA, Messenger; Transfection | 2009 |
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism.
Topics: 3' Untranslated Regions; Cell Line, Tumor; Gene Expression Regulation, Enzymologic; Glutaminase; Glutamine; Humans; MicroRNAs; Mitochondria; Proto-Oncogene Proteins c-myc | 2009 |
Expression of enzymes regulating placental ammonia homeostasis in human fetal growth restricted pregnancies.
Topics: Adult; Ammonia; Down-Regulation; Female; Fetal Growth Retardation; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Homeostasis; Humans; Infant, Newborn; Ketoglutaric Acids; Placenta; Placental Insufficiency; Pregnancy; RNA, Messenger | 2009 |
Roux-en-Y gastric bypass alters small intestine glutamine transport in the obese Zucker rat.
Topics: Amino Acid Transport Systems, Neutral; Animals; Biological Transport; Disease Models, Animal; Gastric Bypass; Gluconeogenesis; Glucose-6-Phosphatase; Glutaminase; Glutamine; Intestinal Mucosa; Intestine, Small; Male; Microvilli; Obesity; Phosphoenolpyruvate Carboxykinase (GTP); Rats; Rats, Zucker; RNA, Messenger; Up-Regulation | 2009 |
Porcine liver sinusoidal endothelial cells contribute significantly to intrahepatic ammonia metabolism.
Topics: Ammonia; Animals; Bioreactors; Endothelial Cells; Glutamic Acid; Glutaminase; Glutamine; Hepatocytes; Lactic Acid; Liver; Lysosomes; Male; Sus scrofa | 2009 |
The protective effect of riluzole on manganese caused disruption of glutamate-glutamine cycle in rats.
Topics: Animals; Blotting, Western; Chlorides; Corpus Striatum; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Female; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Male; Manganese; Manganese Compounds; Manganese Poisoning; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Riluzole; Sodium-Potassium-Exchanging ATPase | 2009 |
Involvement of glutamate in retinal protection against ischemia/reperfusion damage induced by post-conditioning.
Topics: Animals; Electroretinography; Glial Fibrillary Acidic Protein; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Intraocular Pressure; Ischemic Preconditioning; Male; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion Injury; Retina; Tritium | 2009 |
MYC, microRNAs and glutamine addiction in cancers.
Topics: E2F1 Transcription Factor; Glutaminase; Glutamine; Humans; MicroRNAs; Neoplasms; Proto-Oncogene Proteins c-myc; S Phase | 2009 |
Kinetics of a novel isoform of phosphate activated glutaminase (PAG) in SH-SY5Y neuroblastoma cells.
Topics: Ammonia; Cell Line, Tumor; Cell Proliferation; Glutamic Acid; Glutaminase; Glutamine; Humans; Hydrolysis; Isoenzymes; Kinetics; Mitochondria; Phosphates | 2010 |
Glutamine metabolism is essential for human cytomegalovirus infection.
Topics: Adenosine Triphosphate; Ammonia; Cell Survival; Cells, Cultured; Citric Acid Cycle; Cytomegalovirus; Cytomegalovirus Infections; Fibroblasts; Glucose; Glutamate Dehydrogenase; Glutaminase; Glutamine; Glycolysis; Humans; Kinetics; Pyruvic Acid | 2010 |
Crystal structure of salt-tolerant glutaminase from Micrococcus luteus K-3 in the presence and absence of its product L-glutamate and its activator Tris.
Topics: Binding Sites; Catalytic Domain; Crystallization; Crystallography, X-Ray; Glutamic Acid; Glutaminase; Glutamine; Micrococcus luteus; Tromethamine | 2010 |
Hepatic zonation of carbon and nitrogen fluxes derived from glutamine and ammonia transformations.
Topics: Ammonia; Animals; Carbon; Glutaminase; Glutamine; Hepatic Artery; Hepatocytes; Liver; Male; Nitrogen; Perfusion; Rats; Rats, Wistar | 2010 |
Brain edema in acute liver failure: inhibition by L-histidine.
Topics: Ammonia; Animals; Brain; Brain Edema; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Heme Oxygenase-1; Histidine; Liver Failure, Acute; Male; Mitochondria; Permeability; Rats; Rats, Inbred F344 | 2010 |
Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species.
Topics: Animals; Antioxidants; Apoptosis; Glutaminase; Glutamine; Glutathione; Humans; Mice; Mitochondria; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Reactive Oxygen Species; RNA Interference; Tumor Suppressor Protein p53 | 2010 |
Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation.
Topics: Alanine Transaminase; Amino Acid Transport System A; Animals; Aspartate Aminotransferases; Biological Transport; Cell Line, Tumor; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Flow Cytometry; Glutamate Dehydrogenase; Glutaminase; Glutamine; Ketoglutaric Acids; Lymphocyte Activation; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes | 2010 |
Glutaminolysis yields a metabolic by-product that stimulates autophagy.
Topics: Ammonia; Autophagy; Cell Line, Tumor; Culture Media, Conditioned; Glutaminase; Glutamine; Humans; Mitochondria | 2010 |
Anaphase-promoting complex/cyclosome-Cdh1 coordinates glycolysis and glutaminolysis with transition to S phase in human T lymphocytes.
Topics: Amino Acid Motifs; Anaphase-Promoting Complex-Cyclosome; Cdh1 Proteins; Cell Cycle Proteins; G1 Phase; Glutaminase; Glutamine; Humans; Lactic Acid; Phosphofructokinase-2; S Phase; T-Lymphocytes; Ubiquitin-Protein Ligase Complexes | 2010 |
Berberine attenuates lipopolysaccharide-induced impairments of intestinal glutamine transport and glutaminase activity in rat.
Topics: Amino Acid Transport Systems, Neutral; Animals; Berberine; Biological Transport; Glutaminase; Glutamine; Intestinal Mucosa; Intestines; Lipopolysaccharides; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sepsis | 2011 |
Effects of monosodium glutamate supplementation on glutamine metabolism in adult rats.
Topics: Analysis of Variance; Animals; Dietary Supplements; DNA Primers; Gastric Emptying; Gastrointestinal Transit; Gene Expression Regulation, Enzymologic; Glutamic Acid; Glutaminase; Glutamine; Intestinal Mucosa; Kinetics; Muscle, Skeletal; Nitrogen; Protein Biosynthesis; Rats; Sodium Glutamate | 2011 |
Relationship between genetic variation in the glutaminase gene GLS1 and brain glutamine/glutamate ratio measured in vivo.
Topics: Cerebral Cortex; Chromosomes, Human, Pair 2; Databases, Factual; Female; Genotype; Glutamic Acid; Glutaminase; Glutamine; Humans; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Polymorphism, Single Nucleotide; Protons | 2011 |
Hypo-osmotic swelling modifies glutamate-glutamine cycle in the cerebral cortex and in astrocyte cultures.
Topics: Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Cells, Cultured; Cerebral Cortex; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Extracellular Fluid; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Male; Microdialysis; Models, Biological; Rats; Rats, Sprague-Dawley; Saline Solution, Hypertonic; Tritium | 2011 |
Pyruvate carboxylase is required for glutamine-independent growth of tumor cells.
Topics: Cell Line, Tumor; Cell Proliferation; Citric Acid Cycle; Glioblastoma; Glutaminase; Glutamine; Humans; Pyruvate Carboxylase; Pyruvic Acid | 2011 |
Glutamine and α-ketoglutarate as glutamate sources for glutathione synthesis in human erythrocytes.
Topics: Alanine; Alanine Transaminase; Erythrocytes; Glutaminase; Glutamine; Glutathione; Humans; Ketoglutaric Acids; Kinetics; Magnetic Resonance Spectroscopy; Models, Biological | 2011 |
Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia.
Topics: Breast; Breast Neoplasms; Cell Differentiation; Cell Line, Tumor; Cell Lineage; Cell Proliferation; Cell Survival; Coculture Techniques; Culture Media; Epithelium; Female; GATA3 Transcription Factor; Gene Expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Humans; Molecular Targeted Therapy; Nutritional Physiological Phenomena; Phenotype; Promoter Regions, Genetic | 2011 |
Crystal structures of protein glutaminase and its pro forms converted into enzyme-substrate complex.
Topics: Amino Acid Sequence; Catalysis; Catalytic Domain; Chryseobacterium; Crystallization; Crystallography, X-Ray; Cysteine Proteases; Glutaminase; Glutamine; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Proline; Protein Binding; Protein Conformation; Transglutaminases | 2011 |
Glutaminase dysregulation in HIV-1-infected human microglia mediates neurotoxicity: relevant to HIV-1-associated neurocognitive disorders.
Topics: Analysis of Variance; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain; Caspase 3; Cells, Cultured; Chromatography, High Pressure Liquid; Disintegrins; Dizocilpine Maleate; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Antagonists; Fetus; Gene Expression Regulation, Viral; Glutamic Acid; Glutaminase; Glutamine; HIV Infections; HIV-1; Humans; Microglia; Microtubule-Associated Proteins; Receptors, Cell Surface; RNA, Small Interfering; Tetrazolium Salts; Thiazoles; Time Factors | 2011 |
In silico engineering of L-asparaginase to have reduced glutaminase side activity for effective treatment of acute lymphoblastic leukemia.
Topics: Asparaginase; Asparagine; Catalytic Domain; Child; Computer Simulation; Drug Design; Glutaminase; Glutamine; Humans; Ligands; Mutagenesis, Site-Directed; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Engineering | 2011 |
Incorporation of 15N-labeled ammonia into glutamine amide groups by protein-glutaminase and analysis of the reactivity for α-lactalbumin.
Topics: Amino Acid Sequence; Ammonia; Animals; Cattle; Glutaminase; Glutamine; Isotope Labeling; Lactalbumin; Molecular Sequence Data; Nitrogen Isotopes | 2011 |
Glutamine metabolism during aerial mycelium growth of Neurospora crassa.
Topics: Alanine Transaminase; Culture Media; Fungal Proteins; Glutamate Dehydrogenase (NADP+); Glutamate Synthase; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Metabolic Networks and Pathways; Mycelium; Neurospora crassa; Transaminases | 1984 |
Molecular basis for the differential use of glucose and glutamine in cell proliferation as revealed by synchronized HeLa cells.
Topics: Anaphase-Promoting Complex-Cyclosome; Cell Division; DNA Primers; Flow Cytometry; Glucose; Glutaminase; Glutamine; Glycolysis; HeLa Cells; Humans; Immunoblotting; Phosphofructokinase-2; Plasmids; Protein Processing, Post-Translational; SKP Cullin F-Box Protein Ligases; Ubiquitin-Protein Ligase Complexes; Ubiquitination | 2011 |
Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells.
Topics: B-Lymphocytes; Carbon Isotopes; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cell Survival; Citric Acid; Citric Acid Cycle; Fumarates; Glucose; Glutaminase; Glutamine; Humans; Isotope Labeling; Malates; Oxidation-Reduction; Sulfides; Thiadiazoles | 2012 |
Brain slices from glutaminase-deficient mice metabolize less glutamine: a cellular metabolomic study with carbon 13 NMR.
Topics: Animals; Brain; Carbon Dioxide; Carbon Isotopes; Glucose; Glutamic Acid; Glutaminase; Glutamine; Malate Dehydrogenase; Metabolomics; Mice; Mice, Mutant Strains; Nerve Tissue Proteins; Sweetening Agents | 2012 |
Chip-based amperometric enzyme sensor system for monitoring of bioprocesses by flow-injection analysis.
Topics: Biosensing Techniques; Calibration; Catalase; Electrochemical Techniques; Electrodes; Fermentation; Flow Injection Analysis; Glucose; Glucose Oxidase; Glutamic Acid; Glutaminase; Glutamine | 2013 |
Comparative enzymology of (2S,4R)4-fluoroglutamine and (2S,4R)4-fluoroglutamate.
Topics: Alanine Transaminase; Amidohydrolases; Animals; Aspartate Aminotransferases; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Humans; Methionine; Mice; Rats | 2012 |
The NF-κB member p65 controls glutamine metabolism through miR-23a.
Topics: Animals; Base Sequence; Cell Cycle Checkpoints; Cell Death; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Genes, Reporter; Glutaminase; Glutamine; Histone Deacetylases; Humans; Luciferases; Mice; MicroRNAs; Mitochondria; Promoter Regions, Genetic; Transcription Factor RelA; Transcription, Genetic | 2012 |
Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo.
Topics: Animals; Brain Neoplasms; Glioblastoma; Gluconeogenesis; Glucose; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Glycolysis; Humans; Mice; Mice, Inbred NOD; Mice, SCID; Mitochondria; Neoplasm Transplantation; Neostriatum; Oxidation-Reduction; Phenotype; Pyruvate Carboxylase; Statistics, Nonparametric; Tumor Cells, Cultured | 2012 |
Discontinuous ammonia excretion and glutamine storage in littoral Oniscidea (Crustacea: Isopoda): testing tidal and circadian models.
Topics: Ammonia; Animals; Arthropod Proteins; Behavior, Animal; California; Circadian Rhythm; Ecosystem; Enzyme Activation; Glutaminase; Glutamine; Isopoda; Kinetics; Maleates; Models, Biological; Pacific Ocean; Phosphoric Acids; Phylogeny; Species Specificity; Tidal Waves; Trees | 2013 |
Analysis of glutamine dependency in non-small cell lung cancer: GLS1 splice variant GAC is essential for cancer cell growth.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Glutaminase; Glutamine; Glycolysis; Humans; Lung Neoplasms; Molecular Targeted Therapy; Protein Isoforms | 2012 |
Modifying metabolically sensitive histone marks by inhibiting glutamine metabolism affects gene expression and alters cancer cell phenotype.
Topics: Apoptosis; Benzophenanthridines; Breast Neoplasms; Cell Line, Tumor; Cell Survival; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3B; DNA-Binding Proteins; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Histone-Lysine N-Methyltransferase; Histones; Humans; Nuclear Proteins; Promoter Regions, Genetic; Sirtuin 1; Transcription Factors | 2012 |
Catalysis uncoupling in a glutamine amidotransferase bienzyme by unblocking the glutaminase active site.
Topics: Aminohydrolases; Ammonia; Catalysis; Catalytic Domain; Glutaminase; Glutamine; Ligases; Models, Molecular; Protein Conformation; Thermotoga maritima | 2012 |
L-glutamine provides acid resistance for Escherichia coli through enzymatic release of ammonia.
Topics: Ammonia; Escherichia coli; Escherichia coli Proteins; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Membrane Proteins | 2013 |
Control of glutamine metabolism by the tumor suppressor Rb.
Topics: Adenosine Triphosphate; Amino Acid Transport System ASC; Animals; Biological Transport; Cell Cycle; Cell Proliferation; Cells, Cultured; E2F3 Transcription Factor; Fibroblasts; Glutamate-Cysteine Ligase; Glutaminase; Glutamine; Glutathione; Ketoglutaric Acids; Mice; Mice, Knockout; Minor Histocompatibility Antigens; Oxygen; Promoter Regions, Genetic; Reactive Oxygen Species; Retinoblastoma Protein; Retinoblastoma-Like Protein p107; Retinoblastoma-Like Protein p130; RNA Interference; RNA, Small Interfering | 2014 |
A proposed role for glutamine in cancer cell growth through acid resistance.
Topics: Alkanesulfonic Acids; Ammonia; Cell Proliferation; Glutaminase; Glutamine; HeLa Cells; Humans; Hydrogen-Ion Concentration; Kidney; Liver; MCF-7 Cells; Neoplasms; Piperazines | 2013 |
Production and optimization of L-glutaminase enzyme from Hypocrea jecorina pure culture.
Topics: Enzyme Stability; Fermentation; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Hypocrea; Industrial Microbiology; Kinetics; Temperature | 2013 |
Expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer.
Topics: Adult; Amino Acid Transport System ASC; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Glutamate Dehydrogenase; Glutaminase; Glutamine; Humans; Middle Aged; Minor Histocompatibility Antigens; Phenotype; Tissue Array Analysis | 2013 |
The expression of glutamine-metabolism-related proteins in breast phyllodes tumors.
Topics: Adult; Amino Acid Transport System ASC; Breast Neoplasms; Disease-Free Survival; Female; Glutaminase; Glutamine; Humans; Kaplan-Meier Estimate; Laser Capture Microdissection; Middle Aged; Minor Histocompatibility Antigens; Neoplasm Grading; Phyllodes Tumor; Prognosis; Retrospective Studies; Sugar Alcohol Dehydrogenases; Tissue Array Analysis | 2013 |
In vivo and in vitro liver cancer metabolism observed with hyperpolarized [5-(13)C]glutamine.
Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Carbon Isotopes; Cell Line, Tumor; Deoxycytidine; Gemcitabine; Glutaminase; Glutamine; Liver Neoplasms, Experimental; Magnetic Resonance Spectroscopy; Rats | 2013 |
Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia.
Topics: Adult; Aged; Aged, 80 and over; Amino Acid Transport System ASC; Animals; Apoptosis; Asparaginase; Autophagy; Bacterial Proteins; Biological Transport; Cell Line, Tumor; Dickeya chrysanthemi; Drug Screening Assays, Antitumor; Escherichia coli Proteins; Female; Glutaminase; Glutamine; Humans; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Nude; Middle Aged; Minor Histocompatibility Antigens; Multiprotein Complexes; Protein Biosynthesis; RNA Interference; RNA, Small Interfering; Signal Transduction; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays; Young Adult | 2013 |
Identification of the glutaminase genes of Aspergillus sojae involved in glutamate production during soy sauce fermentation.
Topics: Aspergillus; Culture Techniques; Fermentation; Glutamic Acid; Glutaminase; Glutamine; Hydrolysis; Soy Foods | 2013 |
pH-dependent hydrolase, glutaminase, transpeptidase and autotranspeptidase activities of Bacillus subtilis γ-glutamyltransferase.
Topics: Bacillus subtilis; gamma-Glutamyltransferase; Glutaminase; Glutamine; Humans; Hydrogen-Ion Concentration; Hydrolases; Peptidyl Transferases | 2014 |
Structural basis for the active site inhibition mechanism of human kidney-type glutaminase (KGA).
Topics: Binding Sites; Catalytic Domain; Crystallography, X-Ray; Diazooxonorleucine; Glutaminase; Glutamine; Humans; Kidney; Kinetics; Models, Molecular; Mutation; Protein Binding; Protein Conformation; Substrate Specificity | 2014 |
Quantitative metabolome analysis profiles activation of glutaminolysis in glioma with IDH1 mutation.
Topics: Brain Neoplasms; Cell Line, Tumor; Dacarbazine; Glioma; Glutaminase; Glutamine; Glutarates; HEK293 Cells; Humans; Isocitrate Dehydrogenase; Ketoglutaric Acids; Metabolome; Mutation; Temozolomide | 2014 |
A novel glutamine biosensor based on zinc oxide nanorod and glutaminase enzyme from Hypocria jecorina.
Topics: Biosensing Techniques; Buffers; Chitosan; Electrochemical Techniques; Enzymes, Immobilized; Fungal Proteins; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Nanotubes; Powders; Reproducibility of Results; Sensitivity and Specificity; Trichoderma; Zinc Oxide | 2016 |
Glutamine, glutamate, and arginine-based acid resistance in Lactobacillus reuteri.
Topics: Acids; Arginine; Bacterial Proteins; Glutamate Decarboxylase; Glutamic Acid; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Hydrolases; Limosilactobacillus reuteri | 2014 |
The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation.
Topics: Cell Line; DNA-Binding Proteins; Eukaryotic Initiation Factors; Glutaminase; Glutamine; Humans; Mechanistic Target of Rapamycin Complex 1; Mitochondria; Multiprotein Complexes; Phosphorylation; Real-Time Polymerase Chain Reaction; Ribosomal Protein S6 Kinases, 70-kDa; TOR Serine-Threonine Kinases; Transcription Factors | 2014 |
TiO2 nanoparticle-induced neurotoxicity may be involved in dysfunction of glutamate metabolism and its receptor expression in mice.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Female; Gene Expression; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Metal Nanoparticles; Mice; Mice, Inbred ICR; Neurotoxins; Receptors, Metabotropic Glutamate; Titanium | 2016 |
PEG-PHB-glutaminase nanoparticle inhibits cancer cell proliferation in vitro through glutamine deprivation.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Cell Proliferation; DNA Fragmentation; Enzymes, Immobilized; Glutaminase; Glutamine; Glutathione; HeLa Cells; Humans; Hydroxybutyrates; Microscopy, Confocal; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Nanoparticles; Polyesters; Polyethylene Glycols; Prohibitins; Reactive Oxygen Species | 2015 |
Cancerous epithelial cell lines shed extracellular vesicles with a bimodal size distribution that is sensitive to glutamine inhibition.
Topics: Cell Communication; Cell Culture Techniques; Cell Line, Tumor; Enzyme Inhibitors; Epithelial Cells; Exosomes; Extracellular Space; Glutaminase; Glutamine; Humans; Transport Vesicles | 2014 |
Elevated expression of glutaminase confers glucose utilization via glutaminolysis in prostate cancer.
Topics: Adenosine Triphosphate; Carrier Proteins; Cell Line, Tumor; Cell Proliferation; Disease Progression; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glucose; Glutamic Acid; Glutaminase; Glutamine; Glycolysis; Humans; Immunohistochemistry; Male; Neoplasm Invasiveness; Prostate; Prostatic Hyperplasia; Prostatic Neoplasms; RNA Interference | 2015 |
Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells.
Topics: Animals; Apoptosis; Benzoquinones; Cell Line, Tumor; Cell Shape; Cell Survival; Glutamate Dehydrogenase; Glutaminase; Glutamine; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Mechanistic Target of Rapamycin Complex 1; Mice; Models, Biological; Multiprotein Complexes; Oxidation-Reduction; Phenotype; Sirolimus; Small Molecule Libraries; Sulfides; Thiadiazoles; TOR Serine-Threonine Kinases; Tuberous Sclerosis; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins; Xenograft Model Antitumor Assays | 2015 |
Crystal structures capture three states in the catalytic cycle of a pyridoxal phosphate (PLP) synthase.
Topics: Ammonia; Aspartic Acid; Bacterial Proteins; Biocatalysis; Biosynthetic Pathways; Catalytic Domain; Crystallography, X-Ray; Geobacillus stearothermophilus; Glutaminase; Glutamine; Glyceraldehyde 3-Phosphate; Kinetics; Lysine; Models, Molecular; Molecular Structure; Mutation; Protein Conformation; Pyridoxal Phosphate; Ribosemonophosphates; Spectrometry, Mass, Electrospray Ionization | 2015 |
Silencing of glutaminase 1 resensitizes Taxol-resistant breast cancer cells to Taxol.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Female; Glutaminase; Glutamine; Humans; Paclitaxel; RNA Interference; RNA, Small Interfering; Up-Regulation | 2015 |
Glutaminolysis and carcinogenesis of oral squamous cell carcinoma.
Topics: Amino Acid Transport System ASC; Animals; Biomarkers, Tumor; Carcinogenesis; Carcinoma, Squamous Cell; Female; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Humans; Immunohistochemistry; Middle Aged; Minor Histocompatibility Antigens; Mouth Mucosa; Mouth Neoplasms; Oxidoreductases Acting on CH-CH Group Donors; Real-Time Polymerase Chain Reaction; RNA, Neoplasm | 2016 |
Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment.
Topics: Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Benzophenanthridines; Brain Neoplasms; Cell Line, Tumor; Citric Acid Cycle; Drug Resistance, Neoplasm; Drug Synergism; Energy Metabolism; Gas Chromatography-Mass Spectrometry; Glioblastoma; Glutamic Acid; Glutaminase; Glutamine; Glycolysis; Humans; Indoles; Ketoglutaric Acids; Magnetic Resonance Spectroscopy; Male; Metabolome; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Targeted Therapy; Neoplasm Proteins; Protein Kinase Inhibitors; Purines; RNA, Small Interfering; Rotarod Performance Test; Signal Transduction; Temporal Lobe; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2015 |
MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism.
Topics: Animals; Carcinoma, Renal Cell; Cell Line, Tumor; Disease Models, Animal; Disease Progression; Enzyme Inhibitors; Genes, myc; Genes, ras; Glutaminase; Glutamine; Humans; Kidney Neoplasms; Lipid Metabolism; Mice; Mice, SCID; Mice, Transgenic; RNA, Messenger; RNA, Neoplasm; Spectrometry, Mass, Electrospray Ionization; Sulfides; Thiadiazoles; Up-Regulation | 2015 |
Vemurafenib resistance reprograms melanoma cells towards glutamine dependence.
Topics: Animals; Cell Line, Tumor; Cellular Reprogramming; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gene Knockdown Techniques; Glutaminase; Glutamine; GTP Phosphohydrolases; Humans; Indoles; Melanoma; Membrane Proteins; Mice, Inbred NOD; Mice, SCID; Sulfonamides; Vemurafenib | 2015 |
The cpk model of recessive PKD shows glutamine dependence associated with the production of the oncometabolite 2-hydroxyglutarate.
Topics: Animals; Cells, Cultured; Creatine Kinase; Disease Models, Animal; DNA Mutational Analysis; Enzyme Inhibitors; Female; Glutaminase; Glutamine; Glutarates; Humans; Infant; Infant, Newborn; Male; Metabolomics; Mice; Models, Genetic; Polycystic Kidney Diseases | 2015 |
Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibition.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzeneacetamides; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cell Proliferation; Citric Acid Cycle; Enzyme Inhibitors; Gene Knockdown Techniques; Glutaminase; Glutamine; Humans; Leukemia, Myeloid, Acute; Mice; Mitochondria; Oxidative Phosphorylation; Oxygen Consumption; Proto-Oncogene Proteins c-bcl-2; Sulfonamides; Thiadiazoles; Xenograft Model Antitumor Assays | 2015 |
Tumor suppressor NDRG2 inhibits glycolysis and glutaminolysis in colorectal cancer cells by repressing c-Myc expression.
Topics: Amino Acid Transport System ASC; Animals; beta Catenin; Caco-2 Cells; Cell Proliferation; Colorectal Neoplasms; Down-Regulation; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Glucose; Glutaminase; Glutamine; Glycolysis; HCT116 Cells; HEK293 Cells; HT29 Cells; Humans; Lactic Acid; Male; Mice, Nude; Middle Aged; Minor Histocompatibility Antigens; Proto-Oncogene Proteins c-myc; RNA Interference; Signal Transduction; Time Factors; Transcription, Genetic; Transfection; Tumor Burden; Tumor Suppressor Proteins | 2015 |
Long non-coding RNA UCA1 promotes glutamine metabolism by targeting miR-16 in human bladder cancer.
Topics: Carcinoma, Transitional Cell; Glutaminase; Glutamine; Humans; MicroRNAs; Reactive Oxygen Species; RNA, Long Noncoding; Urinary Bladder Neoplasms | 2015 |
Optimality in the zonation of ammonia detoxification in rodent liver.
Topics: Ammonia; Animals; Carbamoyl-Phosphate Synthase (Ammonia); Computer Simulation; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Hepatocytes; Immunohistochemistry; Inactivation, Metabolic; Liver; Male; Mice; Mice, Inbred C57BL; Urea | 2015 |
Interactive effects of glutamine and gamma-aminobutyric acid on growth performance and skeletal muscle amino acid metabolism of 22-42-day-old broilers exposed to hot environment.
Topics: 4-Aminobutyrate Transaminase; Amino Acids; Animal Feed; Animals; Avian Proteins; Chickens; Dietary Supplements; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Heat Stress Disorders; Hot Temperature; Humidity; Male; Muscle, Skeletal | 2016 |
Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2.
Topics: Animals; Apoptosis; Blotting, Western; Cell Proliferation; Chromatin Immunoprecipitation; Enzyme Activation; Glutaminase; Glutamine; Glycolysis; Humans; Hydrolysis; Immunoenzyme Techniques; Mice; Mice, Inbred NOD; Mice, SCID; Neuroblastoma; Proto-Oncogene Proteins c-myc; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2015 |
Q-ing tumor glutaminase for therapy.
Topics: Animals; Enzyme Inhibitors; Glutaminase; Glutamine; Humans; Mice; Neoplasms | 2015 |
Lactate promotes glutamine uptake and metabolism in oxidative cancer cells.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Glutaminase; Glutamine; HeLa Cells; Humans; Lactic Acid; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Monocarboxylic Acid Transporters; Neoplasms; Oxidation-Reduction; Symporters | 2016 |
Enhanced OXPHOS, glutaminolysis and β-oxidation constitute the metastatic phenotype of melanoma cells.
Topics: Animals; Cell Line, Tumor; Cell Movement; Glucose; Glutaminase; Glutamine; Lactates; Melanocytes; Melanoma; Membrane Potentials; Metabolism; Mice; Oxidation-Reduction; Oxidative Phosphorylation; Oxygen Consumption; Phenotype | 2016 |
Replication of the Shrimp Virus WSSV Depends on Glutamate-Driven Anaplerosis.
Topics: Animals; Aspartate Aminotransferases; Chromones; Citric Acid Cycle; Gene Dosage; Genome, Viral; Glutamate Dehydrogenase; Glutamic Acid; Glutaminase; Glutamine; Hemocytes; Hemolymph; Ketoglutaric Acids; Metabolomics; Morpholines; Penaeidae; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Double-Stranded; RNA, Messenger; Sirolimus; TOR Serine-Threonine Kinases; Virus Replication; White spot syndrome virus 1 | 2016 |
Dlx-2 and glutaminase upregulate epithelial-mesenchymal transition and glycolytic switch.
Topics: Adenosine Triphosphate; Apoptosis; Blotting, Western; Cell Proliferation; Chromatin Immunoprecipitation; Epithelial-Mesenchymal Transition; Fluorescent Antibody Technique; Glutaminase; Glutamine; Glycolysis; HeLa Cells; Hep G2 Cells; Homeodomain Proteins; Humans; MCF-7 Cells; Neoplasms; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Snail Family Transcription Factors; Transcription Factors; Transforming Growth Factor beta; Tumor Cells, Cultured | 2016 |
HIF-1α Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell Survival.
Topics: Animals; Bone Regeneration; Cell Respiration; Cell Survival; Energy Metabolism; Gene Deletion; Gene Knockdown Techniques; Gene Silencing; Glutaminase; Glutamine; Glycogen; Homeostasis; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Neovascularization, Physiologic; Osteocytes; Oxidation-Reduction; Oxidative Stress; Periosteum; Reactive Oxygen Species | 2016 |
Blockage of glutaminolysis enhances the sensitivity of ovarian cancer cells to PI3K/mTOR inhibition involvement of STAT3 signaling.
Topics: Antineoplastic Agents; Apoptosis; Benzeneacetamides; Blotting, Western; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Flow Cytometry; Gene Knockdown Techniques; Glutaminase; Glutamine; Humans; Indoles; Ovarian Neoplasms; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Purines; Real-Time Polymerase Chain Reaction; Signal Transduction; STAT3 Transcription Factor; Thiadiazoles; TOR Serine-Threonine Kinases | 2016 |
mTORC1-Dependent Metabolic Reprogramming Underlies Escape from Glycolysis Addiction in Cancer Cells.
Topics: Adenosine Triphosphate; Animals; Carcinoma; Cell Line, Tumor; Citric Acid Cycle; Combined Modality Therapy; Cytokines; Deoxyglucose; Drug Resistance, Neoplasm; Drug Synergism; Energy Metabolism; Everolimus; Female; Glucose-6-Phosphate Isomerase; Glutaminase; Glutamine; Glycolysis; Hep G2 Cells; Humans; Mechanistic Target of Rapamycin Complex 1; Metabolomics; Mice; Mice, Nude; Molecular Targeted Therapy; Multiprotein Complexes; Neoplasm Proteins; Neoplasms; Ovarian Neoplasms; Pentose Phosphate Pathway; Ribosomal Protein S6 Kinases, 70-kDa; RNA Interference; RNA, Small Interfering; TOR Serine-Threonine Kinases; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays | 2016 |
The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy.
Topics: Animals; Base Sequence; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Embryo, Mammalian; Fibroblasts; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Humans; MCF-7 Cells; Mice; Molecular Sequence Data; Neoplasms; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Mas; Proto-Oncogene Proteins c-jun; Reverse Transcriptase Polymerase Chain Reaction; rho GTP-Binding Proteins; RNA Interference | 2016 |
Alanyl-glutamine supplementation regulates mTOR and ubiquitin proteasome proteolysis signaling pathways in piglets.
Topics: Alanine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Dietary Supplements; Dipeptides; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Liver; Male; Muscle, Skeletal; Proteasome Endopeptidase Complex; Proteolysis; RNA, Messenger; Signal Transduction; Sus scrofa; TOR Serine-Threonine Kinases; Ubiquitins; Weight Gain | 2016 |
Altered glutamine metabolism in platinum resistant ovarian cancer.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cisplatin; Drug Resistance, Neoplasm; Female; Glutaminase; Glutamine; Humans; Metabolic Networks and Pathways; Ovarian Neoplasms; Proteome | 2016 |
Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target.
Topics: Adult; Aged; Aged, 80 and over; Amino Acid Transport System ASC; Ammonium Compounds; Animals; Asparaginase; Biological Transport; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Silencing; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Humans; Male; Membrane Transport Proteins; Mice, Inbred NOD; Mice, SCID; Middle Aged; Minor Histocompatibility Antigens; Molecular Targeted Therapy; Monoclonal Gammopathy of Undetermined Significance; Multiple Myeloma; Syndecan-1 | 2016 |
LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer.
Topics: Animals; Carcinogenesis; Diethylnitrosamine; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Liver; Liver Neoplasms; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Knockout; Mitochondria; Multiprotein Complexes; Receptors, Cytoplasmic and Nuclear; Signal Transduction; TOR Serine-Threonine Kinases | 2016 |
Inhibition of the oxidative stress-induced miR-23a protects the human retinal pigment epithelium (RPE) cells from apoptosis through the upregulation of glutaminase and glutamine uptake.
Topics: Apoptosis; Cell Line; Cell Survival; Gene Expression Regulation; Glutaminase; Glutamine; Humans; Hydrogen Peroxide; MicroRNAs; Oxidative Stress; Retinal Pigment Epithelium; Up-Regulation | 2016 |
Glutamine deprivation plus BPTES alters etoposide- and cisplatin-induced apoptosis in triple negative breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cell Survival; Cisplatin; Culture Media; Dose-Response Relationship, Drug; Etoposide; Female; Glutaminase; Glutamine; Humans; Immunoblotting; Sulfides; Thiadiazoles; Triple Negative Breast Neoplasms | 2016 |
Expression of glutamine metabolism-related proteins in thyroid cancer.
Topics: Adult; Aged; Amino Acid Transport System ASC; Female; Glutaminase; Glutamine; Humans; Male; Middle Aged; Minor Histocompatibility Antigens; Sugar Alcohol Dehydrogenases; Thyroid Neoplasms | 2016 |
PDHA1 gene knockout in prostate cancer cells results in metabolic reprogramming towards greater glutamine dependence.
Topics: Aged; Gene Knockout Techniques; Glutamate Dehydrogenase; Glutaminase; Glutamine; Humans; Male; Middle Aged; Prostatic Neoplasms; Pyruvate Dehydrogenase (Lipoamide) | 2016 |
T Helper Cell Activation and Expansion Is Sensitive to Glutaminase Inhibition under Both Hypoxic and Normoxic Conditions.
Topics: Antigens, CD; Cell Proliferation; Cells, Cultured; Cytokines; Glutaminase; Glutamine; Humans; Lymphocyte Activation; Mitochondria; Oxygen; Receptors, Chemokine; T-Lymphocytes, Helper-Inducer | 2016 |
Aging Reduces an ERRalpha-Directed Mitochondrial Glutaminase Expression Suppressing Glutamine Anaplerosis and Osteogenic Differentiation of Mesenchymal Stem Cells.
Topics: Aging; Animals; Bone Resorption; Calcification, Physiologic; Cell Differentiation; Cellular Senescence; ERRalpha Estrogen-Related Receptor; Gene Expression Regulation; Glutaminase; Glutamine; Humans; Male; Mesenchymal Stem Cells; Mice, Inbred C57BL; Mitochondria; Osteogenesis; Promoter Regions, Genetic; Protein Binding; Receptors, Estrogen; RNA, Messenger | 2017 |
Mechanistic Basis of Glutaminase Activation: A KEY ENZYME THAT PROMOTES GLUTAMINE METABOLISM IN CANCER CELLS.
Topics: Animals; Cell Line, Tumor; Enzyme Activation; Glutaminase; Glutamine; Humans; Mice; Neoplasm Proteins; Neoplasms; NIH 3T3 Cells; Protein Multimerization; Protein Structure, Secondary | 2016 |
Combination therapy with BPTES nanoparticles and metformin targets the metabolic heterogeneity of pancreatic cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzeneacetamides; Cell Line, Tumor; Glutaminase; Glutamine; Humans; Metformin; Mice; Nanoparticles; Pancreatic Neoplasms; Proto-Oncogene Proteins p21(ras); Sulfides; Thiadiazoles; Xenograft Model Antitumor Assays | 2016 |
Glutaminolysis Was Induced by TGF-β1 through PP2Ac Regulated Raf-MEK-ERK Signaling in Endothelial Cells.
Topics: Cell Movement; Enzyme Activation; Gene Knockdown Techniques; Glutaminase; Glutamine; Human Umbilical Vein Endothelial Cells; Humans; MAP Kinase Signaling System; Models, Biological; Okadaic Acid; Protein Phosphatase 2; raf Kinases; RNA, Small Interfering; Transforming Growth Factor beta1 | 2016 |
Glutamine metabolism of Corynebacterium glutamicum: role of the glutaminase GlsK.
Topics: Ammonium Compounds; Corynebacterium glutamicum; Gene Deletion; Genome, Bacterial; Glutaminase; Glutamine | 2016 |
Enzyme activities involved in the glutamate-glutamine cycle are altered to reduce glutamate after spinal cord injury in rats.
Topics: Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Enzyme Activation; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Rats; Rats, Wistar; Spinal Cord Injuries; Time Factors | 2016 |
Inhibiting glutaminase in acute myeloid leukemia: metabolic dependency of selected AML subtypes.
Topics: Antineoplastic Agents; Apoptosis; Benzeneacetamides; Cell Differentiation; Cell Proliferation; Energy Metabolism; Enzyme Inhibitors; Glutamate Dehydrogenase; Glutamic Acid; Glutaminase; Glutamine; Glutarates; Humans; Isocitrate Dehydrogenase; Leukemia, Myeloid, Acute; Mutation; Protein Isoforms; Sulfides; Thiadiazoles | 2016 |
Glutaminases.
Topics: Animals; Glutamic Acid; Glutaminase; Glutamine; Humans; Proteomics; Research | 2016 |
Glutamine Metabolism in Gliomas.
Topics: Brain Neoplasms; Cell Proliferation; Glioma; Glutamic Acid; Glutaminase; Glutamine; Humans; Neoplasm Invasiveness | 2016 |
Selenite inhibits glutamine metabolism and induces apoptosis by regulating GLS1 protein degradation via APC/C-CDH1 pathway in colorectal cancer cells.
Topics: Adenomatous Polyposis Coli Protein; Antigens, CD; Antineoplastic Agents; Apoptosis; Blotting, Western; Cadherins; Cell Line, Tumor; Colorectal Neoplasms; Fluorescent Antibody Technique; Gene Knockdown Techniques; Glutaminase; Glutamine; Humans; Immunohistochemistry; Immunoprecipitation; Real-Time Polymerase Chain Reaction; Selenious Acid; Signal Transduction | 2017 |
Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC.
Topics: A549 Cells; Adenosine Triphosphate; Animals; Aspartic Acid; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Death; Cell Proliferation; Cell Survival; Cytosol; Drug Synergism; Fluorouracil; Gene Knockdown Techniques; Glutamic Acid; Glutaminase; Glutamine; Lung Neoplasms; Malates; Mice, Inbred BALB C; Mice, Nude; Molecular Targeted Therapy; NAD; Oxidation-Reduction; Sulfides; Thiadiazoles; Thymidylate Synthase; Xenograft Model Antitumor Assays | 2016 |
Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Benzeneacetamides; Carbon Radioisotopes; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; ErbB Receptors; Erlotinib Hydrochloride; Fluorodeoxyglucose F18; Glutaminase; Glutamine; Humans; Lung Neoplasms; Mice; Mice, SCID; Mutation; Radiopharmaceuticals; RNA Interference; Thiadiazoles; Transplantation, Heterologous | 2017 |
Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers.
Topics: Animals; Arginine; Argininosuccinate Synthase; Carrier Proteins; Cell Line, Tumor; Cell Proliferation; Citric Acid Cycle; Culture Media; Glucose; Glutaminase; Glutamine; Glycolysis; Humans; Hydrolases; Membrane Proteins; Metabolomics; Mice; Phosphoglycerate Dehydrogenase; Phosphorylation; Polyethylene Glycols; RNA Interference; Serine; Thyroid Hormone-Binding Proteins; Thyroid Hormones; Up-Regulation | 2017 |
The differential ability of asparagine and glutamine in promoting the closed/active enzyme conformation rationalizes the Wolinella succinogenes L-asparaginase substrate specificity.
Topics: Amino Acid Sequence; Amino Acids; Asparaginase; Asparagine; Conserved Sequence; Enzyme Activation; Glutaminase; Glutamine; Kinetics; Models, Molecular; Point Mutation; Protein Conformation; Substrate Specificity; Wolinella | 2017 |
Increased Expression of Glutaminase in Osteoblasts Promotes Macrophage Recruitment in Periapical Lesions.
Topics: Animals; Blotting, Western; Cells, Cultured; Disease Progression; Glutaminase; Glutamine; Humans; Macrophages; Osteoblasts; Periapical Periodontitis; Rats; Rats, Sprague-Dawley | 2017 |
MicroRNA-153 regulates glutamine metabolism in glioblastoma through targeting glutaminase.
Topics: Brain Neoplasms; Cell Growth Processes; Cell Line, Tumor; Down-Regulation; Glioblastoma; Glutaminase; Glutamine; Humans; Immunohistochemistry; In Situ Hybridization; MicroRNAs | 2017 |
Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers.
Topics: Animals; Carcinoma, Renal Cell; Glutamates; Glutaminase; Glutamine; Humans; Kidney Neoplasms; Mice; Mice, Nude; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; S Phase Cell Cycle Checkpoints; Von Hippel-Lindau Tumor Suppressor Protein; Xenograft Model Antitumor Assays | 2017 |
Glutaminase 1 plays a key role in the cell growth of fibroblast-like synoviocytes in rheumatoid arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Blotting, Western; Cell Proliferation; Female; Fibroblasts; Gene Knockdown Techniques; Glutaminase; Glutamine; Immunohistochemistry; Mice; Real-Time Polymerase Chain Reaction; Synoviocytes | 2017 |
Impaired Glutamatergic Neurotransmission in the Ventromedial Hypothalamus May Contribute to Defective Counterregulation in Recurrently Hypoglycemic Rats.
Topics: Animals; Astrocytes; Blood Glucose; Carbon Isotopes; Carbon-13 Magnetic Resonance Spectroscopy; Glutamic Acid; Glutaminase; Glutamine; Homeostasis; Hypoglycemia; Hypoglycemic Agents; Hypothalamus; Insulin; Microdialysis; Proton Magnetic Resonance Spectroscopy; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Recurrence; Synaptic Transmission | 2017 |
Kr-POK (ZBTB7c) regulates cancer cell proliferation through glutamine metabolism.
Topics: Animals; Cell Death; Cell Line; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; HEK293 Cells; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Proteins; RNA, Small Interfering; STAT1 Transcription Factor; Transcription Factors; Transcription, Genetic | 2017 |
Sensitization of melanoma cells to temozolomide by overexpression of microRNA 203 through direct targeting of glutaminase-mediated glutamine metabolism.
Topics: Antineoplastic Agents, Alkylating; Cell Line, Tumor; Dacarbazine; Down-Regulation; Drug Resistance, Neoplasm; Glutaminase; Glutamine; Humans; Melanoma; MicroRNAs; Temozolomide | 2017 |
Role of glutamine and interlinked asparagine metabolism in vessel formation.
Topics: Asparagine; Cell Movement; Cell Proliferation; Culture Media; Endothelial Cells; Glutaminase; Glutamine; Human Umbilical Vein Endothelial Cells; Humans; Metabolic Networks and Pathways; Neovascularization, Pathologic; Neovascularization, Physiologic | 2017 |
Glutamine fuels proliferation but not migration of endothelial cells.
Topics: Carbon Isotopes; Cell Movement; Cell Proliferation; Culture Media; Endothelial Cells; Gene Deletion; Glutaminase; Glutamine; Human Umbilical Vein Endothelial Cells; Humans; Isotope Labeling | 2017 |
Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Female; Glutaminase; Glutamine; Humans; Male; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Pancreatic Neoplasms; Proteomics; Xenograft Model Antitumor Assays | 2017 |
MicroRNA-200c exacerbates the ischemia/reperfusion injury of heart through targeting the glutaminase (GLS)-mediated glutamine metabolism.
Topics: Animals; Glutaminase; Glutamine; Male; MicroRNAs; Myocardial Reperfusion Injury; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2017 |
A Critical Role of Glutamine and Asparagine γ-Nitrogen in Nucleotide Biosynthesis in Cancer Cells Hijacked by an Oncogenic Virus.
Topics: Asparagine; Aspartate Aminotransferases; Aspartic Acid; Cell Proliferation; Glutamate Dehydrogenase; Glutamic Acid; Glutaminase; Glutamine; Herpesvirus 8, Human; Humans; Metabolic Networks and Pathways; Neoplasms; Nitrogen; Nucleotides | 2017 |
Sex differences in the glutamate signaling pathway in juvenile rats.
Topics: Animals; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamate Plasma Membrane Transport Proteins; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Male; Rats; Rats, Wistar; Sex Factors; Signal Transduction | 2018 |
An LC-MS Approach to Quantitative Measurement of Ammonia Isotopologues.
Topics: Ammonia; Chromatography, Liquid; Glutaminase; Glutamine; Humans; Indophenol; Isotope Labeling; Mass Spectrometry; Metabolomics; Molecular Structure | 2017 |
Glutaminase inhibition improves FLT3 inhibitor therapy for acute myeloid leukemia.
Topics: Animals; Benzeneacetamides; Benzothiazoles; Cell Line, Tumor; Female; fms-Like Tyrosine Kinase 3; Glutamic Acid; Glutaminase; Glutamine; Humans; Leukemia, Myeloid, Acute; Mice; Mice, Inbred NOD; Mice, Transgenic; Phenylurea Compounds; Thiadiazoles; Xenograft Model Antitumor Assays | 2018 |
Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression synergizes with mTOR inhibition.
Topics: Cell Line, Tumor; Female; Glutaminase; Glutamine; Humans; TOR Serine-Threonine Kinases; Triple Negative Breast Neoplasms | 2017 |
Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Clustered Regularly Interspaced Short Palindromic Repeats; Genes, ras; Glutaminase; Glutamine; Humans; Hydrolysis; Kelch-Like ECH-Associated Protein 1; Lung Neoplasms; Mice | 2017 |
Role of the Transforming Growth Factor-β in regulating hepatocellular carcinoma oxidative metabolism.
Topics: Autocrine Communication; Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Fatty Acids; Glucose; Glutaminase; Glutamine; Glycolysis; Hepatocytes; Humans; Large Neutral Amino Acid-Transporter 1; Metabolome; Oxidative Phosphorylation; Oxygen Consumption; Receptor, Transforming Growth Factor-beta Type I; Transcriptome; Transforming Growth Factor beta1 | 2017 |
TAp73 is a marker of glutamine addiction in medulloblastoma.
Topics: AMP-Activated Protein Kinases; Animals; Cell Line, Tumor; Cell Proliferation; Cerebellar Neoplasms; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Heterografts; Humans; Medulloblastoma; Mice; Mitochondria; Nuclear Proteins; Survival Analysis; TOR Serine-Threonine Kinases; Treatment Outcome; Tumor Cells, Cultured; Tumor Protein p73 | 2017 |
Rapid quantification of glutaminase 2 (GLS2)-related metabolites by HILIC-MS/MS.
Topics: Cell Line, Tumor; Chromatography, High Pressure Liquid; Glutamic Acid; Glutaminase; Glutamine; Glutathione; Humans; Hydrophobic and Hydrophilic Interactions; Limit of Detection; Tandem Mass Spectrometry | 2017 |
Glutaminolysis Promotes Collagen Translation and Stability via α-Ketoglutarate-mediated mTOR Activation and Proline Hydroxylation.
Topics: Actins; Animals; Benzeneacetamides; Cells, Cultured; Collagen; Disease Models, Animal; Elastin; Enzyme Activation; Fibronectins; Glutaminase; Glutamine; Humans; Hydroxylation; Ketoglutaric Acids; Mice; Mice, Inbred C57BL; Myofibroblasts; Proline; Pulmonary Fibrosis; RNA Interference; RNA, Small Interfering; Sulfides; Thiadiazoles; TOR Serine-Threonine Kinases | 2018 |
Glutamine Addiction in Kidney Cancer Suppresses Oxidative Stress and Can Be Exploited for Real-Time Imaging.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Benzeneacetamides; Carcinoma, Renal Cell; Deoxyguanosine; Glutaminase; Glutamine; Humans; Kidney Neoplasms; Mice; NF-E2 Transcription Factor; Oxidative Stress; Reactive Oxygen Species; Thiadiazoles; Xenograft Model Antitumor Assays | 2017 |
miR-137 inhibits glutamine catabolism and growth of malignant melanoma by targeting glutaminase.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Glutaminase; Glutamine; Heterografts; Humans; Melanoma; Mice; Mice, Nude; MicroRNAs; Prognosis; Skin Neoplasms | 2018 |
MYC regulation of glutamine-proline regulatory axis is key in luminal B breast cancer.
Topics: Aldehyde Dehydrogenase; Breast Neoplasms; delta-1-Pyrroline-5-Carboxylate Reductase; Female; Gene Dosage; Gene Regulatory Networks; Genes, myc; Glutaminase; Glutamine; Humans; Proline; Proto-Oncogene Proteins c-myc; Pyrroline Carboxylate Reductases; RNA, Messenger | 2018 |
Metabolic Differences in Glutamine Utilization Lead to Metabolic Vulnerabilities in Prostate Cancer.
Topics: Benzeneacetamides; Cell Line, Tumor; Glutaminase; Glutamine; Humans; Male; Nuclear Magnetic Resonance, Biomolecular; Prostatic Neoplasms; Thiadiazoles | 2017 |
A New Step in the Treatment of Sickle Cell Disease
Topics: Amide Synthases; Ammonia; Anemia, Sickle Cell; Animals; Antisickling Agents; Drug Discovery; Glutaminase; Glutamine; Humans; NAD | 2018 |
The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Transport System ASC; Animals; Biomarkers, Tumor; Breast Neoplasms; Disease Models, Animal; DNA-Binding Proteins; Ephrin-A2; Female; Glutaminase; Glutamine; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mice, Knockout; Minor Histocompatibility Antigens; Muscle Proteins; Phosphoproteins; Receptor, EphA2; TEA Domain Transcription Factors; Trans-Activators; Transcription Factors; Transcriptional Coactivator with PDZ-Binding Motif Proteins; Tumor Cells, Cultured; YAP-Signaling Proteins | 2017 |
Glutaminolysis is required for transforming growth factor-β1-induced myofibroblast differentiation and activation.
Topics: Cell Differentiation; Cell Line; Glutaminase; Glutamine; Humans; Ketoglutaric Acids; Myofibroblasts; p38 Mitogen-Activated Protein Kinases; Smad3 Protein; Transforming Growth Factor beta1 | 2018 |
Expression of the glutamine metabolism-related proteins glutaminase 1 and glutamate dehydrogenase in canine mammary tumours.
Topics: Analysis of Variance; Animals; Breast Neoplasms; Dog Diseases; Dogs; Female; Glutamate Dehydrogenase; Glutaminase; Glutamine; Humans; Immunohistochemistry; Mammary Neoplasms, Animal; Republic of Korea | 2018 |
Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells.
Topics: Adaptor Proteins, Signal Transducing; Animals; Case-Control Studies; Cell Cycle Proteins; Cell Proliferation; Cell Transdifferentiation; Cells, Cultured; Cellular Reprogramming; Energy Metabolism; Gene Expression Regulation; Glutaminase; Glutamine; Hedgehog Proteins; Hepatic Stellate Cells; Humans; Ketoglutaric Acids; Liver; Liver Cirrhosis; Liver Cirrhosis, Experimental; Mice, Inbred C57BL; Mice, Knockout; Mitochondria, Liver; Myofibroblasts; Phenotype; Phosphoproteins; Rats; RNA Interference; Signal Transduction; Smoothened Receptor; Time Factors; Transcription Factors; Transfection; YAP-Signaling Proteins | 2018 |
Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism.
Topics: Allosteric Site; Amino Acid Substitution; Antineoplastic Agents; Benzeneacetamides; Binding, Competitive; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Glutaminase; Glutamine; Humans; Hydrogen Bonding; Models, Molecular; Molecular Conformation; Mutation; Neoplasm Proteins; Recombinant Proteins; Sulfides; Thiadiazoles; Triple Negative Breast Neoplasms | 2018 |
Let-7 Suppresses B Cell Activation through Restricting the Availability of Necessary Nutrients.
Topics: Amino Acid Transport System ASC; Animals; B-Lymphocytes; CD5 Antigens; Cell Respiration; Glucose; Glutaminase; Glutamine; Glycolysis; HEK293 Cells; Hexokinase; Humans; Immunoglobulin M; Lymphocyte Activation; Mice; MicroRNAs; Minor Histocompatibility Antigens; Mitochondria; Nutrients; Proto-Oncogene Proteins c-myc | 2018 |
A Novel l-Asparaginase with low l-Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias
Topics: Animals; Antineoplastic Agents; Asparaginase; Cell Line, Tumor; Female; Glutaminase; Glutamine; Humans; Male; Mice, Inbred C57BL; Mice, SCID; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Recombinant Proteins; Toxicity Tests, Acute; Xenograft Model Antitumor Assays | 2018 |
Del11q-positive CLL lymphocytes exhibit altered glutamine metabolism and differential response to GLS1 and glucose metabolism inhibition.
Topics: Chromosome Deletion; Chromosomes, Human, Pair 11; Female; Glucose; Glutaminase; Glutamine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male | 2018 |
Glutamine metabolism via glutaminase 1 in autosomal-dominant polycystic kidney disease.
Topics: Animals; Aquaporin 2; Benzeneacetamides; Cell Proliferation; Cells, Cultured; Female; Glutaminase; Glutamine; Humans; Male; Mice; Mice, Knockout; Polycystic Kidney, Autosomal Dominant; Receptors, Cell Surface; Signal Transduction; Thiadiazoles | 2018 |
Rational cell culture optimization enhances experimental reproducibility in cancer cells.
Topics: Animals; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Glutaminase; Glutamine; Humans; Metabolomics; Neoplasms; Reproducibility of Results; Research Design; Thiadiazoles | 2018 |
Transcriptional factor ICER promotes glutaminolysis and the generation of Th17 cells.
Topics: Animals; Autoimmunity; Cyclic AMP Response Element Modulator; Encephalomyelitis, Autoimmune, Experimental; Glutaminase; Glutamine; Mice; Mice, Transgenic; Th17 Cells | 2018 |
Glutaminase 1 regulates the release of extracellular vesicles during neuroinflammation through key metabolic intermediate alpha-ketoglutarate.
Topics: Aniline Compounds; Benzeneacetamides; Benzylidene Compounds; Brain; Calcium-Binding Proteins; Cell Cycle Proteins; Cells, Cultured; Central Nervous System; Ceramides; Dose-Response Relationship, Drug; Endosomal Sorting Complexes Required for Transport; Enzyme Inhibitors; Extracellular Vesicles; Glutamates; Glutaminase; Glutamine; HIV Infections; Humans; Lipopolysaccharides; Macrophages; Membrane Proteins; Microglia; Sulfides; Thiadiazoles | 2018 |
Metformin modifies glutamine metabolism in an in vitro and in vivo model of hepatic encephalopathy.
Topics: Ammonia; Animals; Caco-2 Cells; Child, Preschool; Glutaminase; Glutamine; Hepatic Encephalopathy; Humans; Hypoglycemic Agents; Male; Metformin; Rats; Rats, Wistar | 2018 |
Glutamatergic hypofunction in medication-free major depression: Secondary effects of affective diagnosis and relationship to peripheral glutaminase.
Topics: Adult; Case-Control Studies; Depressive Disorder, Major; Female; Glutamic Acid; Glutaminase; Glutamine; Gyrus Cinguli; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Young Adult | 2018 |
Targeting glutaminolysis in chondrosarcoma in context of the IDH1/2 mutation.
Topics: Antineoplastic Agents; Benzeneacetamides; Bone Neoplasms; Chloroquine; Chondrosarcoma; Drug Screening Assays, Antitumor; Glutaminase; Glutamine; Humans; Immunohistochemistry; Isocitrate Dehydrogenase; Metabolic Networks and Pathways; Metformin; Molecular Targeted Therapy; Mutation; Neoplasm Grading; Thiadiazoles; Tumor Cells, Cultured | 2018 |
Targeting hepatic glutaminase activity to ameliorate hyperglycemia.
Topics: Animals; Cells, Cultured; Cryopreservation; Glucagon; Glutaminase; Glutamine; Hepatocytes; Humans; Hyperglycemia; Kinetics; Liver; Metabolic Flux Analysis; Mice, Inbred C57BL; Mice, Knockout | 2018 |
Molecular targeting of glutaminase sensitizes ovarian cancer cells to chemotherapy.
Topics: Antineoplastic Agents; Cell Proliferation; Drug Resistance, Neoplasm; Female; Glutaminase; Glutamine; Humans; Molecular Targeted Therapy; Ovarian Neoplasms; Sulfides; Thiadiazoles; Tumor Cells, Cultured | 2018 |
Targeting Therapy Resistance: When Glutamine Catabolism Becomes Essential.
Topics: Carcinoma, Squamous Cell; Glutaminase; Glutamine; Glycogen Synthase Kinase 3; Humans; Lung Neoplasms | 2018 |
Accelerated lipid catabolism and autophagy are cancer survival mechanisms under inhibited glutaminolysis.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Benzophenanthridines; Cell Line, Tumor; Cell Proliferation; Chloroquine; Glutaminase; Glutamine; Humans; Lipolysis; Metabolomics; Neoplasms; Oxidative Stress | 2018 |
Glutaminase GLS1 senses glutamine availability in a non-enzymatic manner triggering mitochondrial fusion.
Topics: Animals; Cells, Cultured; Fibroblasts; Gene Knockdown Techniques; Glutaminase; Glutamine; GTP Phosphohydrolases; Mitochondria; Mitochondrial Dynamics; Peroxisomal Multifunctional Protein-2; Reactive Oxygen Species | 2018 |
Targeting glutaminase-mediated glutamine dependence in papillary thyroid cancer.
Topics: Adult; Aged; Apoptosis; Autophagy; Biomarkers; Cell Line, Tumor; Cell Movement; Cell Respiration; Female; Glutaminase; Glutamine; Humans; Male; Mechanistic Target of Rapamycin Complex 1; Middle Aged; Mitochondria; Neoplasm Staging; Signal Transduction; Thyroid Cancer, Papillary; Tumor Burden | 2018 |
NRH:quinone oxidoreductase 2 (NQO2) and glutaminase (GLS) both play a role in large extracellular vesicles (LEV) formation in preclinical LNCaP-C4-2B prostate cancer model of progressive metastasis.
Topics: Amino Acid Sequence; Binding Sites; Caveolin 1; Cell Line, Tumor; Disease Progression; Extracellular Vesicles; Glutaminase; Glutamine; Humans; Immunoblotting; Male; Models, Molecular; NAD(P)H Dehydrogenase (Quinone); Neoplasm Metastasis; Oxidative Stress; Prostatic Neoplasms; Quinone Reductases | 2018 |
Structure of the essential peptidoglycan amidotransferase MurT/GatD complex from Streptococcus pneumoniae.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Catalytic Domain; Cell Wall; Glutamic Acid; Glutaminase; Glutamine; Lipids; Mycobacterium tuberculosis; Oxidoreductases; Peptidoglycan; Protein Domains; Staphylococcal Infections; Staphylococcus aureus; Streptococcus pneumoniae; Sulfhydryl Compounds | 2018 |
Activation of p53 by costunolide blocks glutaminolysis and inhibits proliferation in human colorectal cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Cell Nucleus; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; HCT116 Cells; Humans; Phosphorylation; Protein Transport; Sesquiterpenes; Time Factors; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53 | 2018 |
Glutaminolysis Epigenetically Regulates Antiapoptotic Gene Expression in Idiopathic Pulmonary Fibrosis Fibroblasts.
Topics: Apoptosis; Cells, Cultured; Epigenesis, Genetic; Fibroblasts; Gene Expression Regulation; Glutaminase; Glutamine; Humans; Idiopathic Pulmonary Fibrosis; Survivin; X-Linked Inhibitor of Apoptosis Protein | 2019 |
Expression of glutamine metabolism-related proteins in Hürthle cell neoplasm of thyroid: Comparison with follicular neoplasm.
Topics: Adenocarcinoma, Follicular; Adenoma, Oxyphilic; Adult; Amino Acid Transport System ASC; Female; Glutamate Dehydrogenase; Glutaminase; Glutamine; Humans; Male; Middle Aged; Minor Histocompatibility Antigens; Thyroid Neoplasms | 2019 |
GLS hyperactivity causes glutamate excess, infantile cataract and profound developmental delay.
Topics: Adolescent; Animals; Brain; Cataract; Child, Preschool; Developmental Disabilities; Disease Models, Animal; Female; Fibroblasts; Gain of Function Mutation; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; HEK293 Cells; Humans; Male; Oxidative Stress; Reactive Oxygen Species; Zebrafish | 2019 |
"Pinching" the ammonia tunnel of CTP synthase unveils coordinated catalytic and allosteric-dependent control of ammonia passage.
Topics: Adenosine Triphosphate; Alkylation; Allosteric Regulation; Amino Acid Sequence; Ammonia; Binding Sites; Carbon-Nitrogen Ligases; Catalysis; Chlorides; Crystallography, X-Ray; Cytidine Triphosphate; Glutaminase; Glutamine; Hydrolysis; Kinetics; Mutagenesis, Site-Directed; Protein Conformation; Uridine Triphosphate; Valine | 2018 |
Glutaminase Affects the Transcriptional Activity of Peroxisome Proliferator-Activated Receptor γ (PPARγ) via Direct Interaction.
Topics: Gene Expression Regulation; Glutaminase; Glutamine; Humans; Luciferases; Models, Molecular; PPAR gamma; Protein Conformation; Protein Domains; Protein Isoforms; Transcription, Genetic | 2018 |
iTRAQ-Based Quantitative Proteomics Approach Identifies Novel Diagnostic Biomarkers That Were Essential for Glutamine Metabolism and Redox Homeostasis for Gastric Cancer.
Topics: Biomarkers, Tumor; Chromatography, Liquid; Female; gamma-Glutamylcyclotransferase; Gene Expression Regulation, Developmental; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Humans; Male; Mass Spectrometry; Neoplasm Proteins; Proteomics; Stomach Neoplasms | 2019 |
Targeting glucose and glutamine metabolism combined with radiation therapy in non-small cell lung cancer.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Radiation; Enzyme Inhibitors; Glucose; Glutaminase; Glutamine; Glycolysis; Humans; Indazoles; Lung Neoplasms; Radiation Tolerance; X-Rays | 2018 |
Molecular Imaging of mGluR5 Availability with [
Topics: Animals; Brain; Carbon Radioisotopes; Glutaminase; Glutamine; Heterozygote; Mice; Molecular Imaging; Oximes; Pyridines; Receptor, Metabotropic Glutamate 5 | 2019 |
Glutaminase inhibitor CB-839 increases radiation sensitivity of lung tumor cells and human lung tumor xenografts in mice.
Topics: Animals; Benzeneacetamides; Cell Line, Tumor; Female; Glutaminase; Glutamine; Glutathione; Humans; Lung Neoplasms; Male; Mice; Radiation Tolerance; Thiadiazoles; Xenograft Model Antitumor Assays | 2019 |
Identification of a Loss-of-Function Mutation in the Context of Glutaminase Deficiency and Neonatal Epileptic Encephalopathy.
Topics: Brain; Brain Diseases; Epilepsy; Female; Glutaminase; Glutamine; Humans; Infant; Infant, Newborn; Male; Mutation; Seizures | 2019 |
Metformin Impairs Glutamine Metabolism and Autophagy in Tumour Cells.
Topics: Adaptor Proteins, Signal Transducing; Ammonia; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Cisplatin; Glutaminase; Glutamine; HeLa Cells; Humans; MCF-7 Cells; Metformin; Microtubule-Associated Proteins; Neoadjuvant Therapy | 2019 |
Mitochondrial GPT2 plays a pivotal role in metabolic adaptation to the perturbation of mitochondrial glutamine metabolism.
Topics: A549 Cells; Adaptation, Physiological; Cells, Cultured; Glutaminase; Glutamine; HCT116 Cells; HeLa Cells; Humans; MCF-7 Cells; Mitochondria; Reactive Oxygen Species; Transaminases | 2019 |
miR-206 inhibits osteogenic differentiation of bone marrow mesenchymal stem cells by targetting glutaminase.
Topics: 3' Untranslated Regions; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Gene Expression Regulation; Glutaminase; Glutamine; Humans; Mesenchymal Stem Cells; MicroRNAs; Osteoblasts; Osteocalcin; Osteogenesis; Osteopontin | 2019 |
Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma.
Topics: Animals; Antineoplastic Agents; Benzeneacetamides; Cell Line, Tumor; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Drug Resistance, Neoplasm; Drug Synergism; Energy Metabolism; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; F-Box Proteins; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Humans; Hypoglycemic Agents; Male; Mechanistic Target of Rapamycin Complex 1; Metformin; Mice; Molecular Targeted Therapy; Phenformin; Protein Kinase Inhibitors; Retinoblastoma Protein; Signal Transduction; Thiadiazoles; Xenograft Model Antitumor Assays | 2019 |
Targeting cellular metabolism to reduce head and neck cancer growth.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease-Free Survival; Drug Synergism; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Head and Neck Neoplasms; Humans; Metabolic Networks and Pathways; Metformin; Sulfides; Thiadiazoles | 2019 |
LincRNA-p21 suppresses glutamine catabolism and bladder cancer cell growth through inhibiting glutaminase expression.
Topics: Cell Line, Tumor; Cell Proliferation; Down-Regulation; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Humans; RNA, Long Noncoding; Urinary Bladder Neoplasms | 2019 |
BAG3 promotes autophagy and glutaminolysis via stabilizing glutaminase.
Topics: Adaptor Proteins, Signal Transducing; Ammonia; Apoptosis Regulatory Proteins; Autophagy; Enzyme Stability; Glutaminase; Glutamine; Hep G2 Cells; Humans; MCF-7 Cells; Mitochondria; Neoplasms; Proteasome Endopeptidase Complex; Proteolysis; Sirtuins; Transfection; Ubiquitination | 2019 |
Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in
Topics: Amino Acid Metabolism, Inborn Errors; Ataxia; Atrophy; Cerebellum; Child, Preschool; Developmental Disabilities; Female; Genotype; Glutaminase; Glutamine; Humans; Male; Microsatellite Repeats; Mutation; Phenotype; Polymerase Chain Reaction; Whole Genome Sequencing | 2019 |
A novel function of anaphase promoting complex subunit 10 in tumor progression in non-small cell lung cancer.
Topics: A549 Cells; Apc10 Subunit, Anaphase-Promoting Complex-Cyclosome; Autophagy; Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Cell Movement; Cell Proliferation; Cytoplasm; Disease Progression; G1 Phase; Glutaminase; Glutamine; Humans; Lung Neoplasms; Resting Phase, Cell Cycle; RNA, Small Interfering; Signal Transduction; Transfection | 2019 |
Preventing Glutaminolysis: A Potential Therapy for Pulmonary Fibrosis.
Topics: Glutaminase; Glutamine; Humans; Idiopathic Pulmonary Fibrosis | 2019 |
Dual inhibition of glutaminase and carnitine palmitoyltransferase decreases growth and migration of glutaminase inhibition-resistant triple-negative breast cancer cells.
Topics: Benzeneacetamides; Carnitine O-Palmitoyltransferase; Cell Movement; Cell Proliferation; Drug Resistance, Neoplasm; Female; Glutaminase; Glutamine; Humans; Oxidation-Reduction; Thiadiazoles; Triple Negative Breast Neoplasms; Tumor Cells, Cultured | 2019 |
Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer.
Topics: Animals; Biomarkers; Breast Neoplasms; Cell Line, Tumor; Computational Biology; Disease Models, Animal; Enzyme Inhibitors; Female; Gene Expression Profiling; Glutaminase; Glutamine; Humans; Immunohistochemistry; Magnetic Resonance Spectroscopy; Metabolomics; Mice; Models, Biological; Proline; Xenograft Model Antitumor Assays | 2019 |
MicroRNA-200a-3p accelerates the progression of osteoporosis by targeting glutaminase to inhibit osteogenic differentiation of bone marrow mesenchymal stem cells.
Topics: Base Sequence; Cell Differentiation; Disease Progression; Down-Regulation; Glutaminase; Glutamine; Humans; Mesenchymal Stem Cells; MicroRNAs; Osteogenesis; Osteoporosis | 2019 |
miR-145 inhibits glutamine metabolism through c-myc/GLS1 pathways in ovarian cancer cells.
Topics: DNA-Binding Proteins; Female; Glutaminase; Glutamine; Humans; MicroRNAs; Ovarian Neoplasms; Transcription Factors; Tumor Cells, Cultured | 2019 |
Inhibition of ERRα Prevents Mitochondrial Pyruvate Uptake Exposing NADPH-Generating Pathways as Targetable Vulnerabilities in Breast Cancer.
Topics: Animals; Antineoplastic Agents; Biological Transport; Breast Neoplasms; ERRalpha Estrogen-Related Receptor; Female; Gene Expression Regulation, Neoplastic; Glucosephosphate Dehydrogenase; Glutaminase; Glutamine; Glycolysis; Homeostasis; Humans; Mice; Mice, Inbred NOD; Mice, SCID; Mitochondria; NADP; Oxidation-Reduction; Pentose Phosphate Pathway; Pyruvic Acid; Receptors, Estrogen; Tumor Cells, Cultured | 2019 |
Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer.
Topics: Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glutamic Acid; Glutaminase; Glutamine; Humans; Lyases; Metabolic Networks and Pathways; Pancreatic Neoplasms; Transaminases | 2019 |
Glutaminase 1 Inhibition Reduces Glycolysis and Ameliorates Lupus-like Disease in MRL/lpr Mice and Experimental Autoimmune Encephalomyelitis.
Topics: Adult; Animals; CD4-Positive T-Lymphocytes; Cell Differentiation; Encephalomyelitis, Autoimmune, Experimental; Female; Glutaminase; Glutamine; Glycolysis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; In Vitro Techniques; Lupus Erythematosus, Systemic; Mice; Mice, Inbred MRL lpr; Mice, Knockout; Middle Aged; Sulfides; Th17 Cells; Thiadiazoles | 2019 |
Inhibition of Glucose Transporters and Glutaminase Synergistically Impairs Tumor Cell Growth.
Topics: Benzeneacetamides; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Citric Acid Cycle; Female; Glucose; Glucose Transport Proteins, Facilitative; Glucose Transporter Type 1; Glucose Transporter Type 3; Glutaminase; Glutamine; Glycolysis; Humans; Male; Neoplasms; Thiadiazoles | 2019 |
Estrogen inhibits autophagy and promotes growth of endometrial cancer by promoting glutamine metabolism.
Topics: Autophagy; Cell Proliferation; Endometrial Neoplasms; Estrogens; Female; Glutaminase; Glutamine; Humans; Signal Transduction; Tumor Cells, Cultured | 2019 |
Physapubescin I from husk tomato suppresses SW1990 cancer cell growth by targeting kidney-type glutaminase.
Topics: Animals; Antineoplastic Agents; Apoptosis; Binding Sites; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Escherichia coli; Glutaminase; Glutamine; Heterografts; Humans; Kidney; Ligands; Male; Mice; Mice, SCID; Molecular Docking Simulation; Protein Binding; Protein Conformation; Solanum lycopersicum; Withanolides | 2019 |
Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in GLS.
Topics: Glutaminase; Glutamine; Microsatellite Repeats | 2019 |
Glutaminase Deficiency Caused by Short Tandem Repeat Expansion in GLS. Reply.
Topics: Glutaminase; Glutamine; Microsatellite Repeats | 2019 |
Starving the Devourer: Cutting Cancer Off from Its Favorite Foods.
Topics: Cell Proliferation; Glucose; Glucose Transport Proteins, Facilitative; Glutaminase; Glutamine | 2019 |
Glutamine Metabolism in Both the Oxidative and Reductive Directions Is Triggered in Shrimp Immune Cells (Hemocytes) at the WSSV Genome Replication Stage to Benefit Virus Replication.
Topics: Animals; DNA Virus Infections; Genome, Viral; Glutaminase; Glutamine; Hemocytes; Isocitrate Dehydrogenase; Ketoglutarate Dehydrogenase Complex; Oxidation-Reduction; Penaeidae; Virus Replication; White spot syndrome virus 1 | 2019 |
Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer.
Topics: Animals; Breast Neoplasms; Carcinogenesis; Cell Line; Cell Line, Tumor; DNA Methylation; Female; GATA3 Transcription Factor; Genes, Tumor Suppressor; Glutaminase; Glutamine; HEK293 Cells; Humans; Liver; MCF-7 Cells; Mice; Promoter Regions, Genetic | 2019 |
Contribution of glutaminases to glutamine metabolism and acid resistance in Lactobacillus reuteri and other vertebrate host adapted lactobacilli.
Topics: Acids; Animals; Bacterial Proteins; Fermentation; Glutamic Acid; Glutaminase; Glutamine; Humans; Hydrogen-Ion Concentration; Lactobacillus; Limosilactobacillus reuteri; Phylogeny; Rodentia | 2020 |
Metabolic fingerprinting reveals extensive consequences of GLS hyperactivity.
Topics: Asparagine; Cell Line, Tumor; Glutamic Acid; Glutaminase; Glutamine; Glutathione; HEK293 Cells; Humans; Mass Spectrometry; Metabolic Networks and Pathways; Proline | 2020 |
A novel protein glutaminase from Bacteroides helcogenes-characterization and comparison.
Topics: Bacteroides; Escherichia coli; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Recombinant Proteins; Temperature | 2020 |
Studies on the potential link between antidepressant effect of Xiaoyao San and its pharmacological activity of hepatoprotection based on multi-platform metabolomics.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Drugs, Chinese Herbal; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Humans; Liver; Male; Medicine, Chinese Traditional; Metabolomics; Protective Agents; Proton Magnetic Resonance Spectroscopy; Rats | 2020 |
Knock-down of PSAT1 Enhances Sensitivity of NSCLC Cells to Glutamine-limiting Conditions.
Topics: Activating Transcription Factor 4; Benzeneacetamides; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Gene Knock-In Techniques; Glutaminase; Glutamine; Humans; Lung; Lung Neoplasms; Radiation Tolerance; RNA, Messenger; Thiadiazoles; Transaminases | 2019 |
Acidosis-induced metabolic reprogramming in tumor cells enhances the anti-proliferative activity of the PDK inhibitor dichloroacetate.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dichloroacetic Acid; Drug Synergism; Female; Glutaminase; Glutamine; Glycolysis; Humans; Hydrogen-Ion Concentration; Mice; Neoplasms; Pentose Phosphate Pathway; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Sulfides; Thiadiazoles; Xenograft Model Antitumor Assays | 2020 |
Glutamine Skipping the Q into Mitochondria.
Topics: Amino Acid Transport System ASC; Animals; Cell Proliferation; Cytoplasm; Glutaminase; Glutamine; Humans; Mitochondria; Neoplasms | 2020 |
The activation loop and substrate-binding cleft of glutaminase C are allosterically coupled.
Topics: Allosteric Regulation; Allosteric Site; Amino Acid Substitution; Animals; Benzeneacetamides; Biomedical Engineering; Catalytic Domain; Glutaminase; Glutamine; Kinetics; Mice; Mitochondria; Models, Molecular; Mutation; Protein Isoforms; Protein Structure, Tertiary; Recombinant Proteins; Sulfides; Thiadiazoles | 2020 |
Increased Glutaminolysis Marks Active Scarring in Nonalcoholic Steatohepatitis Progression.
Topics: Adult; Amino Acid Transport System ASC; Animals; Biomarkers; Cell Line; Cicatrix; Disease Models, Animal; Disease Progression; Female; Glutaminase; Glutamine; Hepatic Stellate Cells; Humans; Liver; Liver Cirrhosis; Male; Metabolomics; Mice; Middle Aged; Minor Histocompatibility Antigens; Myofibroblasts; Non-alcoholic Fatty Liver Disease; Positron-Emission Tomography | 2020 |
Undermining Glutaminolysis Bolsters Chemotherapy While NRF2 Promotes Chemoresistance in KRAS-Driven Pancreatic Cancers.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Deoxycytidine; Drug Resistance, Neoplasm; Gemcitabine; Glutaminase; Glutamine; Heterografts; Humans; Mice; Mice, Nude; Mutation; Neoplasm Proteins; NF-E2-Related Factor 2; Pancreatic Neoplasms; Prognosis; Proto-Oncogene Proteins p21(ras); Random Allocation; Tissue Array Analysis; Up-Regulation | 2020 |
Different ways to transport ammonia in human and Mycobacterium tuberculosis NAD
Topics: Amide Synthases; Ammonia; Bacterial Proteins; Carbon-Nitrogen Ligases with Glutamine as Amide-N-Donor; Catalytic Domain; Glutaminase; Glutamine; Humans; Mycobacterium tuberculosis; NAD; Substrate Specificity | 2020 |
Targeting glutamine metabolism slows soft tissue sarcoma growth.
Topics: Allografts; Animals; Benzeneacetamides; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Glutaminase; Glutamine; Mice; Nucleosides; RNA, Messenger; Sarcoma; Thiadiazoles; Tomography, X-Ray Computed | 2020 |
G protein-coupled kisspeptin receptor induces metabolic reprograming and tumorigenesis in estrogen receptor-negative breast cancer.
Topics: Adult; Aged; Animals; Carcinogenesis; Case-Control Studies; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cellular Reprogramming; Energy Metabolism; Female; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Humans; Mice, Inbred NOD; Mice, SCID; Middle Aged; Neoplasm Invasiveness; Nucleotides; Proto-Oncogene Proteins c-myc; Receptors, Kisspeptin-1; Signal Transduction; Triple Negative Breast Neoplasms; Tumor Burden; Young Adult | 2020 |
Metabolic Reprogramming of Host Cells in Response to Enteroviral Infection.
Topics: Animals; Chlorocebus aethiops; Cytopathogenic Effect, Viral; Dihydroorotase; Enterovirus A, Human; Enterovirus Infections; Gene Knockdown Techniques; Glutamate Dehydrogenase; Glutamic Acid; Glutaminase; Glutamine; Glycolysis; Host-Pathogen Interactions; Ketoglutaric Acids; RNA Interference; Transfection; Vero Cells; Virus Replication | 2020 |
Hyperoxia induces glutamine-fuelled anaplerosis in retinal Müller cells.
Topics: Animals; Astrocytes; Carbon Isotopes; Cells, Cultured; Endothelial Cells; Ependymoglial Cells; Glucose; Glutaminase; Glutamine; Glycolysis; Humans; Hyperoxia; Metabolome; Mice; Mitochondria; Models, Biological; Oxidation-Reduction; Phosphorylation; Pyruvate Dehydrogenase Complex | 2020 |
ASCT2 overexpression is associated with poor survival of OSCC patients and ASCT2 knockdown inhibited growth of glutamine-addicted OSCC cells.
Topics: Aged; Amino Acid Transport System ASC; Animals; Cell Line, Tumor; Cell Proliferation; Female; Gene Knockdown Techniques; Glutaminase; Glutamine; Glutathione; Humans; Immunohistochemistry; Male; Mice; Mice, Nude; Middle Aged; Minor Histocompatibility Antigens; Mouth Neoplasms; Neoplasm Transplantation; Reactive Oxygen Species; Squamous Cell Carcinoma of Head and Neck | 2020 |
A shift in glutamine nitrogen metabolism contributes to the malignant progression of cancer.
Topics: Amidophosphoribosyltransferase; Animals; Biosynthetic Pathways; Cell Line, Tumor; Disease Progression; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Humans; Metabolomics; Mice, Nude; Models, Biological; Molecular Targeted Therapy; Neoplasms; Nitrogen; Prognosis | 2020 |
Snakehead vesiculovirus (SHVV) infection alters striped snakehead (Ophicephalus striatus) cells (SSN-1) glutamine metabolism and apoptosis pathways.
Topics: Animals; Apoptosis; Cell Line; Fish Diseases; Fish Proteins; Fishes; Glutaminase; Glutamine; Rhabdoviridae Infections; Vesiculovirus; Virus Replication | 2020 |
Molecular modeling and LC-MS-based metabolomics of a glutamine-valproic acid (Gln-VPA) derivative on HeLa cells.
Topics: Antineoplastic Agents; Cell Proliferation; Cell Survival; Chromatography, Liquid; Glutaminase; Glutamine; HeLa Cells; Humans; Mass Spectrometry; Metabolome; Metabolomics; Models, Molecular; Valproic Acid | 2021 |
Pyruvate anaplerosis is a mechanism of resistance to pharmacological glutaminase inhibition in triple-receptor negative breast cancer.
Topics: Benzeneacetamides; Cell Proliferation; Drug Resistance, Neoplasm; Female; Glutaminase; Glutamine; Humans; Pyruvic Acid; Thiadiazoles; Triple Negative Breast Neoplasms; Tumor Cells, Cultured; Tumor Microenvironment | 2020 |
Glutamine Metabolism Controls Chondrocyte Identity and Function.
Topics: Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chondrocytes; Female; Glutaminase; Glutamine; Male; Mice; SOX9 Transcription Factor | 2020 |
Dendrimer-conjugated glutaminase inhibitor selectively targets microglial glutaminase in a mouse model of Rett syndrome.
Topics: Animals; Dendrimers; Disease Models, Animal; Female; Glutamic Acid; Glutaminase; Glutamine; Male; Mice; Mice, Knockout; Microglia; Neuroglia; Neuroimmunomodulation; Oxidative Stress; Rett Syndrome | 2020 |
Oxidation of energy substrates in tissues of largemouth bass (Micropterus salmoides).
Topics: Adenosine Triphosphate; Amino Acids; Animals; Aspartic Acid; Bass; Glucose; Glutamate Dehydrogenase; Glutamic Acid; Glutaminase; Glutamine; Leucine; Liver; Muscle, Skeletal; Oxidation-Reduction; Palmitates; Transaminases; Tromethamine | 2020 |
Glutamine Antagonist JHU-083 Normalizes Aberrant Hippocampal Glutaminase Activity and Improves Cognition in APOE4 Mice.
Topics: Alzheimer Disease; Animals; Apolipoprotein E4; Azo Compounds; Caproates; Cell Line; Cells, Cultured; Cognition; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Glutaminase; Glutamine; Hippocampus; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia | 2020 |
Identifying strategies to target the metabolic flexibility of tumours.
Topics: Animals; Cell Proliferation; Glucose; Glutaminase; Glutamine; Humans; Liver Neoplasms; Mice; Proto-Oncogene Proteins c-myc | 2020 |
Mouse Model for Efficient Simultaneous Targeting of Glycolysis, Glutaminolysis, and De Novo Synthesis of Fatty Acids in Colon Cancer.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Colonic Neoplasms; Diazooxonorleucine; Drug Screening Assays, Antitumor; Fatty Acid Synthase, Type I; Fatty Acids; Female; Glutaminase; Glutamine; Glycolysis; Hexokinase; Indazoles; Mice; Mice, Inbred BALB C; Molecular Targeted Therapy; Orlistat; Smegmamorpha | 2021 |
Mass production of active recombinant Chryseobacterium proteolyticum protein glutaminase in Escherichia coli using a sequential dual expression system and one-step purification.
Topics: Chromatography, Affinity; Chryseobacterium; Escherichia coli; Glutaminase; Glutamine; Hydrogen-Ion Concentration; Nickel; Recombinant Fusion Proteins; Solubility | 2020 |
GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis.
Topics: Adult; Aged; Animals; Case-Control Studies; Cell Differentiation; Disease Models, Animal; Female; Glutaminase; Glutamine; Humans; Interleukin-17; Keratinocytes; Male; Metabolic Networks and Pathways; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein; Psoriasis; RNA, Messenger; T-Lymphocyte Subsets; Th17 Cells; Young Adult | 2020 |
Inhibition of the MYC-Regulated Glutaminase Metabolic Axis Is an Effective Synthetic Lethal Approach for Treating Chemoresistant Ovarian Cancers.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzeneacetamides; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Glutathione; Humans; Mice, Nude; Ovarian Neoplasms; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Proto-Oncogene Proteins c-myc; Thiadiazoles; Xenograft Model Antitumor Assays | 2020 |
A facile and sensitive method of quantifying glutaminase binding to its inhibitor CB-839 in tissues.
Topics: Animals; Benzeneacetamides; Cell Line, Tumor; Colonic Neoplasms; Glutaminase; Glutamine; Heterografts; Humans; Mice; Thiadiazoles | 2020 |
A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer.
Topics: Amino Acid Transport System ASC; Animals; Antineoplastic Agents; Apoptosis; Benzeneacetamides; Carrier Proteins; Cell Line, Tumor; Drug Synergism; Glutaminase; Glutamine; Humans; Liver Neoplasms; Mice; Minor Histocompatibility Antigens; Reactive Oxygen Species; Thiadiazoles; Xenograft Model Antitumor Assays | 2020 |
p53-dependent glutamine usage determines susceptibility to oxidative stress in radioresistant head and neck cancer cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Glucose; Glutaminase; Glutamine; Glutathione; Glycolysis; Head and Neck Neoplasms; Humans; NADP; Oxidation-Reduction; Oxidative Stress; Radiation Tolerance; Reactive Oxygen Species; Signal Transduction; Tumor Suppressor Protein p53 | 2021 |
Critical role of glutamine metabolism in cardiomyocytes under oxidative stress.
Topics: Animals; Animals, Newborn; Cell Survival; Cells, Cultured; Citric Acid Cycle; Energy Metabolism; Glutamic Acid; Glutaminase; Glutamine; Heart Failure; Ketoglutaric Acids; Metabolic Networks and Pathways; Myocytes, Cardiac; Oxidative Stress; Rats | 2021 |
Glutamine Metabolism in Osteoprogenitors Is Required for Bone Mass Accrual and PTH-Induced Bone Anabolism in Male Mice.
Topics: Animals; Bone Density; Glutaminase; Glutamine; Male; Mice; Osteoblasts; Osteogenesis; Parathyroid Hormone | 2021 |
Kinetic Modeling of
Topics: Animals; Glutaminase; Glutamine; Kinetics; Mice | 2021 |
Translation in amino-acid-poor environments is limited by tRNA
Topics: Amino Acids; Animals; Cell Line, Tumor; Glutaminase; Glutamine; Humans; Mice; Peptides; Protein Biosynthesis; RNA, Transfer, Gln; Transfer RNA Aminoacylation | 2020 |
Glutaminolysis is a metabolic route essential for survival and growth of prostate cancer cells and a target of 5α-dihydrotestosterone regulation.
Topics: Amino Acid Transport System ASC; Androgens; Anilides; Animals; Caspase 3; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dihydrotestosterone; Gene Expression Regulation, Neoplastic; Glucose; Glutaminase; Glutamine; Glycolysis; Humans; Lactic Acid; Lipid Metabolism; Male; Minor Histocompatibility Antigens; Models, Biological; Neoplasm Proteins; Nitriles; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rats; Sulfides; Thiadiazoles; Tosyl Compounds | 2021 |
Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation.
Topics: Adult; Alternaria; Animals; Asthma; Biomarkers; Blood Glucose; Bronchoalveolar Lavage Fluid; Case-Control Studies; Cells, Cultured; Dexamethasone; Disease Models, Animal; Drug Synergism; Female; Glucose Transporter Type 1; Glutaminase; Glutamine; Healthy Volunteers; Humans; Immunosuppressive Agents; Lung; Male; Mice; Middle Aged; Primary Cell Culture; Pyroglyphidae; Th17 Cells; Th2 Cells; Young Adult | 2021 |
Circ_0000003 regulates glutamine metabolism and tumor progression of tongue squamous cell carcinoma via the miR‑330‑3p/GLS axis.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Gene Knockdown Techniques; Glutaminase; Glutamine; Humans; MicroRNAs; Neoplasm Invasiveness; RNA, Circular; Squamous Cell Carcinoma of Head and Neck; Tongue; Tongue Neoplasms; Up-Regulation | 2021 |
Expression of activated VEGFR2 by R1051Q mutation alters the energy metabolism of Sk-Mel-31 melanoma cells by increasing glutamine dependence.
Topics: Adenosine Triphosphate; Antineoplastic Agents; Cell Line, Tumor; Energy Metabolism; Enzyme Inhibitors; Gain of Function Mutation; Glutaminase; Glutamine; Humans; Melanoma; Signal Transduction; Skin Neoplasms; Vascular Endothelial Growth Factor Receptor-2 | 2021 |
A glutaminase isoform switch drives therapeutic resistance and disease progression of prostate cancer.
Topics: Androgen Antagonists; Animals; Cell Line, Tumor; Computational Biology; Disease Progression; Drug Resistance, Neoplasm; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Humans; Isoenzymes; Male; Mice; Prostate; Prostatic Neoplasms; Receptors, Androgen; Tissue Array Analysis; Xenograft Model Antitumor Assays | 2021 |
SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells.
Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Glutathione; Heterografts; Humans; Male; Mice; Mice, Nude; NADP; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; Phosphorylation; Prognosis; Protein Processing, Post-Translational; Signal Transduction; Succinate-CoA Ligases; Succinic Acid; Survival Analysis | 2021 |
Metabolic Intersection of Cancer and Cardiovascular Diseases: Opportunities for Cancer Therapy.
Topics: Cardiovascular Diseases; Glutamic Acid; Glutaminase; Glutamine; Humans; Neoplasms | 2021 |
Characteristics of a Cold-Adapted L-glutaminase with Potential Applications in the Food Industry.
Topics: Glutaminase; Glutamine; Kinetics | 2021 |
Therapeutic potentiality of a new flavonoid against ketamine induced glutamatergic dysregulation in schizophrenia: In vivo and in silico approach.
Topics: Animals; Antipsychotic Agents; Brain; Celastrus; Flavonoids; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Ketamine; Male; Molecular Docking Simulation; Neuroprotective Agents; Rats, Wistar; Schizophrenia | 2021 |
HPIP protooncogene differentially regulates metabolic adaptation and cell fate in breast cancer cells under glucose stress via AMPK and RNF2 dependent pathways.
Topics: Adaptation, Physiological; AMP-Activated Protein Kinases; Animals; Apoptosis; Breast Neoplasms; Cell Differentiation; Cell Line; Cell Line, Tumor; Female; Glucose; Glutaminase; Glutamine; HEK293 Cells; Humans; Intracellular Signaling Peptides and Proteins; MCF-7 Cells; Mice; Mice, Nude; Minor Histocompatibility Antigens; Polycomb Repressive Complex 1; Stress, Physiological; Ubiquitin-Protein Ligases | 2021 |
GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy.
Topics: Animals; Autophagy; Autophagy-Related Protein 5; Biomarkers, Pharmacological; Cell Line, Tumor; Glutaminase; Glutamine; Humans; Male; Mice, Nude; Neoplastic Stem Cells; Oxidation-Reduction; Prostatic Neoplasms; Proto-Oncogene Proteins c-myc; Radiation Tolerance; Reactive Oxygen Species; Xenograft Model Antitumor Assays | 2021 |
Mucin 5AC Serves as the Nexus for β-Catenin/c-Myc Interplay to Promote Glutamine Dependency During Pancreatic Cancer Chemoresistance.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; beta Catenin; Cell Line, Tumor; Databases, Genetic; Deoxycytidine; Drug Resistance, Neoplasm; Energy Metabolism; Enzyme Inhibitors; Female; Gemcitabine; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Humans; Male; Mice, Knockout; Mice, Nude; Mucin 5AC; Pancreatic Neoplasms; Proto-Oncogene Proteins c-myc; Signal Transduction; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2022 |
Identification and characterization of a novel glutaminase inhibitor.
Topics: Cell Proliferation; Enzyme Inhibitors; Glutaminase; Glutamine; Humans; Thiadiazoles | 2022 |
FAIM regulates autophagy through glutaminolysis in lung adenocarcinoma.
Topics: Adenocarcinoma of Lung; Apoptosis Regulatory Proteins; Autophagy; Glutaminase; Glutamine; Humans; Lung Neoplasms; TOR Serine-Threonine Kinases | 2022 |
The glutaminase inhibitor telaglenastat enhances the antitumor activity of signal transduction inhibitors everolimus and cabozantinib in models of renal cell carcinoma.
Topics: Anilides; Animals; Benzeneacetamides; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Synergism; Everolimus; Female; Gene Expression Regulation, Neoplastic; Glucose; Glutaminase; Glutamine; Humans; Kidney Neoplasms; Mice; Pyridines; Signal Transduction; Thiadiazoles; Xenograft Model Antitumor Assays | 2021 |
The Catalytic Mechanism of Pdx2 Glutaminase Driven by a Cys-His-Glu Triad: A Computational Study.
Topics: Catalysis; Glutamic Acid; Glutaminase; Glutamine; Humans; Malaria; Pyridoxal Phosphate | 2022 |
Circ-CREBBP promotes cell tumorigenesis and glutamine catabolism in glioma by regulating miR-375/glutaminase axis.
Topics: Brain Neoplasms; Carcinogenesis; Cell Proliferation; CREB-Binding Protein; Female; Gene Expression Regulation, Neoplastic; Glioma; Glutaminase; Glutamine; Humans; Male; MicroRNAs; Middle Aged; RNA, Circular; Survival Rate | 2022 |
The Expression of Glutaminases and their Association with Clinicopathological Parameters in the Head and Neck Cancers.
Topics: Glutaminase; Glutamine; Head and Neck Neoplasms; Humans | 2022 |
New insights into the molecular mechanisms of glutaminase C inhibitors in cancer cells using serial room temperature crystallography.
Topics: Crystallography; Enzyme Inhibitors; Glutaminase; Glutamine; Neoplasms; Sulfides; Temperature; Thiadiazoles | 2022 |
Glutaminase 2 knockdown reduces hyperammonemia and associated lethality of urea cycle disorder mouse model.
Topics: Ammonia; Animals; Disease Models, Animal; Glutaminase; Glutamine; Humans; Hyperammonemia; Liver; Mice; Ornithine Carbamoyltransferase; Ornithine Carbamoyltransferase Deficiency Disease; Urea; Urea Cycle Disorders, Inborn | 2022 |
High-resolution structures of mitochondrial glutaminase C tetramers indicate conformational changes upon phosphate binding.
Topics: Catalytic Domain; Glutaminase; Glutamine; Mitochondria; Phosphates; Protein Conformation; Tyrosine | 2022 |
The mTOR/PGC-1α/SIRT3 Pathway Drives Reductive Glutamine Metabolism to Reduce Oxidative Stress Caused by ISKNV in CPB Cells.
Topics: Animals; Cell Line; Fish Diseases; Fish Proteins; Glutaminase; Glutamine; Iridoviridae; NAD; Oxidative Stress; Perches; Phosphorylation; PPAR gamma; Signal Transduction; Sirtuin 3; TOR Serine-Threonine Kinases; Virus Replication | 2022 |
Distinct Roles of Glutamine Metabolism in Benign and Malignant Cartilage Tumors With IDH Mutations.
Topics: Animals; Bone Neoplasms; Cartilage; Chondroma; Chondrosarcoma; Glutaminase; Glutamine; Humans; Isocitrate Dehydrogenase; Ketoglutaric Acids; Mice; Mutation | 2022 |
Inhibition of lncRNA NEAT1 sensitizes medulloblastoma cells to cisplatin through modulating the miR-23a-3p-glutaminase (GLS) axis.
Topics: Cell Line, Tumor; Cerebellar Neoplasms; Cisplatin; Glutaminase; Glutamine; Humans; Medulloblastoma; MicroRNAs; RNA, Long Noncoding | 2022 |
Circ_0001093 promotes glutamine metabolism and cancer progression of esophageal squamous cell carcinoma by targeting miR-579-3p/glutaminase axis.
Topics: Cell Line, Tumor; Cell Movement; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Humans; MicroRNAs | 2022 |
Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis.
Topics: Apoptosis; Asparagine; Glutaminase; Glutamine; Humans; Reactive Oxygen Species | 2022 |
Hyperpolarized [5-
Topics: Biomarkers; Citric Acid Cycle; Glutaminase; Glutamine; Humans; Metabolomics | 2022 |
The Glutaminase Inhibitor Compound 968 Exhibits Potent
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Endometrial Neoplasms; Female; Glutaminase; Glutamine; Humans; Mice; Paclitaxel; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases | 2023 |
Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer.
Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Everolimus; Glutaminase; Glutamine; Lipids; Lysosomes; Mechanistic Target of Rapamycin Complex 1; Mice; MTOR Inhibitors; Nutrients; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Signal Transduction; TOR Serine-Threonine Kinases | 2023 |
Endogenous glutamine is rate-limiting for anti-CD3 and anti-CD28 induced CD4+ T-cell proliferation and glycolytic activity under hypoxia and normoxia.
Topics: Amino Acids; CD28 Antigens; CD3 Complex; CD4-Positive T-Lymphocytes; Cell Proliferation; Glucose; Glutamic Acid; Glutaminase; Glutamine; Humans; Hypoxia; Oxygen; Pyruvic Acid | 2022 |
Topics: Animals; Biomarkers; Carboxylic Acids; Cyclobutanes; Glutaminase; Glutamine; Humans; Kinetics; Mice; Positron-Emission Tomography; Triple Negative Breast Neoplasms | 2023 |
GOT2 Silencing Promotes Reprogramming of Glutamine Metabolism and Sensitizes Hepatocellular Carcinoma to Glutaminase Inhibitors.
Topics: Animals; Antioxidants; Aspartate Aminotransferase, Mitochondrial; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Glutaminase; Glutamine; Glutathione; Humans; Liver Neoplasms; Mice; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases | 2022 |
GLS2 Is a Tumor Suppressor and a Regulator of Ferroptosis in Hepatocellular Carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Ferroptosis; Glutamates; Glutaminase; Glutamine; Humans; Iron; Ketoglutaric Acids; Lipid Peroxides; Liver Neoplasms; Mice; Reactive Oxygen Species | 2022 |
Aliivibrio fischeri L-Asparaginase production by engineered Bacillus subtilis: a potential new biopharmaceutical.
Topics: Aliivibrio fischeri; Antineoplastic Agents; Asparaginase; Asparagine; Bacillus subtilis; Biological Products; Glutaminase; Glutamine; Pharmaceutical Preparations; Xylose | 2022 |
Phosphomimetic Dicer S1016E triggers a switch to glutamine metabolism in gemcitabine-resistant pancreatic cancer.
Topics: Antimetabolites, Antineoplastic; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; DEAD-box RNA Helicases; Deoxycytidine; Drug Resistance, Neoplasm; Gemcitabine; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Humans; MicroRNAs; Pancreatic Neoplasms; Ribonuclease III; RNA, Small Interfering | 2022 |
Structure-based virtual screening discovers novel kidney-type glutaminase inhibitors.
Topics: Cell Line, Tumor; Cell Survival; Glutaminase; Glutamine; Humans; Kidney; Triple Negative Breast Neoplasms | 2022 |
Novel allosteric glutaminase 1 inhibitors with macrocyclic structure activity relationship analysis.
Topics: Animals; Glutamates; Glutaminase; Glutamine; Kelch-Like ECH-Associated Protein 1; NF-E2-Related Factor 2; Proto-Oncogene Proteins p21(ras); Structure-Activity Relationship; Sulfides; Thiadiazoles | 2022 |
Efficacy and Safety of Telaglenastat Plus Cabozantinib vs Placebo Plus Cabozantinib in Patients With Advanced Renal Cell Carcinoma: The CANTATA Randomized Clinical Trial.
Topics: Angiogenesis Inhibitors; Carcinoma, Renal Cell; Double-Blind Method; Female; Glutamates; Glutaminase; Glutamine; Humans; Immune Checkpoint Inhibitors; Ipilimumab; Male; Middle Aged; Nivolumab; Protein Kinase Inhibitors | 2022 |
Inhibition of lncRNA NEAT1 induces dysfunction of fibroblast-like synoviocytes in rheumatoid arthritis via miRNA-338-3p-mediated regulation of glutamine metabolism.
Topics: Apoptosis; Arthritis, Rheumatoid; Cell Proliferation; Cells, Cultured; Fibroblasts; Glutaminase; Glutamine; Humans; Hydrogen Peroxide; MicroRNAs; RNA, Long Noncoding; Synoviocytes | 2022 |
TGF-β3 induces lactate production in Sertoli cell through inhibiting the Notch pathway.
Topics: Adenosine Triphosphate; Animals; Esters; Glucose; Glutaminase; Glutamine; L-Lactate Dehydrogenase; Lactic Acid; Male; p38 Mitogen-Activated Protein Kinases; Phosphofructokinases; Proto-Oncogene Proteins c-akt; Rats; RNA, Small Interfering; Sertoli Cells; Transforming Growth Factor beta3; Transforming Growth Factors | 2022 |
Targeting Glutaminolysis to Treat Multiple Myeloma: An
Topics: Apoptosis; Catechin; Cell Line, Tumor; Cell Proliferation; Glutaminase; Glutamine; Humans; Multiple Myeloma; Proto-Oncogene Proteins c-bcl-2 | 2023 |
GLS1 is a protective factor in patients with ovarian clear cell carcinoma and its expression does not correlate with ARID1A-mutated tumors.
Topics: Adenocarcinoma, Clear Cell; Animals; DNA-Binding Proteins; Female; Glutaminase; Glutamine; Humans; Mice; Ovarian Neoplasms; Protective Factors; Transcription Factors | 2022 |
Inhibition of glutaminolysis ameliorates lupus by regulating T and B cell subsets and downregulating the mTOR/P70S6K/4EBP1 and NLRP3/caspase-1/IL-1β pathways in MRL/lpr mice.
Topics: Animals; B-Lymphocyte Subsets; Caspase 1; Creatinine; Glutamates; Glutaminase; Glutamine; Immunoglobulin G; Interleukin-10; Leukocytes, Mononuclear; Lupus Erythematosus, Systemic; Mice; Mice, Inbred MRL lpr; NLR Family, Pyrin Domain-Containing 3 Protein; Ribosomal Protein S6 Kinases, 70-kDa; T-Lymphocyte Subsets; TOR Serine-Threonine Kinases | 2022 |
Overcoming cisplatin resistance of human lung cancer by sinomenine through targeting the miR-200a-3p-GLS axis.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cisplatin; Drug Resistance, Neoplasm; Glutaminase; Glutamine; Humans; Lung Neoplasms; MicroRNAs | 2023 |
Lithocholic acid inhibits gallbladder cancer proliferation through interfering glutaminase-mediated glutamine metabolism.
Topics: Bile Acids and Salts; Cell Line, Tumor; Cell Proliferation; Gallbladder Neoplasms; Glutaminase; Glutamine; Glutathione Disulfide; Humans; Lipids; Lithocholic Acid; NADP; Reactive Oxygen Species | 2022 |
LncRNA MSC-AS1, as an oncogene in melanoma, promotes the proliferation and glutaminolysis by regulating the miR-330-3p/ YAP1 axis.
Topics: Alanine; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cysteine; Gene Expression Regulation, Neoplastic; Glutamates; Glutaminase; Glutamine; Humans; Ketoglutaric Acids; Melanoma; MicroRNAs; Oncogenes; RNA, Long Noncoding; Serine; YAP-Signaling Proteins | 2022 |
Glutaminase 1 blockade alleviates nonalcoholic steatohepatitis via promoting proline metabolism.
Topics: Animals; Fatty Acids; Glutaminase; Glutamine; Lipid Metabolism; Liver; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Proline | 2022 |
Loss of vascular endothelial glutaminase inhibits tumor growth and metastasis, and increases sensitivity to chemotherapy.
Topics: Animals; Cell Line, Tumor; Glutaminase; Glutamine; Leptin; Mice | 2022 |
Targeting glutaminase is therapeutically effective in ibrutinib-resistant mantle cell lymphoma.
Topics: Adult; Cell Line, Tumor; Drug Resistance, Neoplasm; Enzyme Inhibitors; Glutaminase; Glutamine; Humans; Lymphoma, Mantle-Cell; Neoplasm Recurrence, Local | 2023 |
Glutamine promotes the proliferation of epithelial cells via mTOR/S6 pathway in oral lichen planus.
Topics: Apoptosis; Cell Proliferation; Epithelial Cells; Glutaminase; Glutamine; Humans; Lichen Planus, Oral; Reactive Oxygen Species; TOR Serine-Threonine Kinases | 2023 |
In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma.
Topics: Animals; Carcinoma, Renal Cell; Glutaminase; Glutamine; Humans; Isocitrate Dehydrogenase; Kidney Neoplasms; Mice | 2022 |
Design, synthesis, and biological evaluation of novel glutaminase 1 allosteric inhibitors with an alkane chain tail group.
Topics: Cell Proliferation; Glutaminase; Glutamine; Heterografts; Humans | 2023 |
Combined thioredoxin reductase and glutaminase inhibition exerts synergistic anti-tumor activity in MYC-high high-grade serous ovarian carcinoma.
Topics: Auranofin; Cell Line, Tumor; Female; Genes, myc; Glutaminase; Glutamine; Humans; Ovarian Neoplasms; Thioredoxin-Disulfide Reductase; Thioredoxins | 2023 |
Feasibility of [
Topics: Animals; Colorectal Neoplasms; Disease Models, Animal; ErbB Receptors; Feasibility Studies; Glutamates; Glutaminase; Glutamine; Humans; Mice; Positron-Emission Tomography; Proto-Oncogene Proteins p21(ras) | 2023 |
L-asparaginase anti-tumor activity in pancreatic cancer is dependent on its glutaminase activity and resistance is mediated by glutamine synthetase.
Topics: Asparaginase; Glutamate-Ammonia Ligase; Glutaminase; Glutamine; Humans; Pancreatic Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2023 |
Design, synthesis, structure-activity relationship studies, and evaluation of novel GLS1 inhibitors.
Topics: Animals; Cell Line, Tumor; Glutamic Acid; Glutaminase; Glutamine; Humans; Mice; Structure-Activity Relationship | 2023 |
Glutaminase 1 isoform up-regulation associated with lipid metabolism disorder induced by methyl tertiary-butyl ether in male rats.
Topics: Air Pollutants; Animals; Glutaminase; Glutamine; Lipid Metabolism; Lipid Metabolism Disorders; Male; Methyl Ethers; Protein Isoforms; Rats; Rats, Wistar; Up-Regulation | 2023 |
Substrate Recognition Mechanism of a Trichostatin A-Forming Hydroxyamidotransferase.
Topics: Aspartate-Ammonia Ligase; Glutaminase; Glutamine; Histone Deacetylase Inhibitors; Hydroxamic Acids; Phenylalanine; Proteins | 2023 |
Exosomal MiR-381 from M2-polarized macrophages attenuates urethral fibroblasts activation through YAP/GLS1-regulated glutaminolysis.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cicatrix; Constriction, Pathologic; Fibroblasts; Glutaminase; Glutamine; Macrophages; MicroRNAs; Rabbits; Transcription Factors; Urethral Stricture | 2023 |
Critical role of antioxidant programs in enzalutamide-resistant prostate cancer.
Topics: Androgen Receptor Antagonists; Antioxidants; Cell Line, Tumor; Drug Resistance, Neoplasm; Glutaminase; Glutamine; Humans; Male; Nitriles; Prostatic Neoplasms, Castration-Resistant; Reactive Oxygen Species; Receptors, Androgen | 2023 |
LncRNA PVT1 Confers Cisplatin Resistance of Esophageal Cancer Cells through Modulating the miR-181a-5p-Glutaminase (GLS) Axis.
Topics: Cell Line, Tumor; Cell Proliferation; Cisplatin; Esophageal Neoplasms; Glutaminase; Glutamine; Humans; MicroRNAs; RNA, Long Noncoding | 2023 |
STAG2 inactivation reprograms glutamine metabolism of BRAF-mutant thyroid cancer cells.
Topics: Animals; Cell Cycle Proteins; Cell Line, Tumor; Glutaminase; Glutamine; Humans; Melanoma; Mice; Mice, Nude; Mitogen-Activated Protein Kinase Kinases; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Thyroid Neoplasms | 2023 |
m5C-methylated lncRNA NR_033928 promotes gastric cancer proliferation by stabilizing GLS mRNA to promote glutamine metabolism reprogramming.
Topics: Cell Proliferation; Glutaminase; Glutamine; Humans; RNA, Long Noncoding; RNA, Messenger; Stomach Neoplasms | 2023 |
Optimization of L-glutaminase production by Monascus ruber URM 8542 isolated from ice cream industrial effluent.
Topics: Glutaminase; Glutamine; Ice Cream; Monascus | 2023 |
Glutaminase (GLS1) gene expression in primary breast cancer.
Topics: Breast Neoplasms; Female; Gene Expression; Glutaminase; Glutamine; Humans; Prognosis; Triple Negative Breast Neoplasms | 2023 |