glutamine and fluorouracil

glutamine has been researched along with fluorouracil in 39 studies

Research

Studies (39)

TimeframeStudies, this research(%)All Research%
pre-19906 (15.38)18.7374
1990's6 (15.38)18.2507
2000's9 (23.08)29.6817
2010's15 (38.46)24.3611
2020's3 (7.69)2.80

Authors

AuthorsStudies
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Coit, R; Magno, M; Woolley, PV1
Goh, SH; Léjohn, HB1
Rosen, B; Rothman, F; Weigert, MG1
Burk, D; Woods, MW1
Elia, M; Jebb, SA; Mack, P; Maughan, TS; Mohideen, N; Mort, D; Osborne, RJ; Shelley, MD1
Anderson, PM; Skubitz, KM1
Fujita, H; Matsui, M; Shirouzu, K; Shirouzu, Y; Yamana, H; Yoshida, S1
Sugimura, K; Sukemori, S1
Axvig, C; Clemens-Schutjer, D; Ebbert, LP; LaVasseur, BI; Loprinzi, CL; Michalak, JC; Okuno, SH; Pierson, N; Sloan, JA; Swan, D; Tirona, MR; Woodhouse, CO1
Buhl, K; Decker-Baumann, C; Dueck, M; Frohmüller, S; Schlag, PM; von Herbay, A1
Abbiati, R; Barletta, E; D'Agostino, L; Daniele, B; De Martino, S; De Vivo, R; Gallo, C; Perrone, F; Pignata, S; Tambaro, R1
ANDERSON, EP; BROCKMAN, RW1
WU, C1
Ansari, R; Cheng, L; Helft, P; Juliar, B; Loehrer, P; Pan, CX; Pletcher, W; Seitz, D; Sweeney, C; Vinson, J1
Choi, K; Jeon, WK; Kim, JW; Lee, SS; Lim, SY; Oh, SJ; Oh, TY1
Chen, PM; Chen, WS; Chiou, TJ; Jiang, JK; Lin, JK; Lin, TC; Liu, JH; Wang, HS; Wang, WS; Yen, CC1
Bellaguarda, EA; Brito, GA; Leitão, RF; Lira, AM; Macedo, FD; Ribeiro, RA; Silva, LR; Sousa, RB1
Braga-Neto, MB; Brito, GA; Guerrant, RL; Lima, AA; Maciel, AA; Monteiro, MS; Oriá, RB; Warren, CA1
Baracos, VE; Dieleman, LA; Field, CJ; Le Roy, S; Sawyer, MB; Xue, H1
Kaji, H; Maiguma, T; Makino, K; Teshima, D1
Cuezva, JM; Sánchez-Aragó, M1
Anderluh, F; Kompan, L; Mlakar Mastnak, D; Možina, B; Oblak, I; Rotovnik Kozjek, N; Soeters, P; Velenik, V; Zadnik, V1
Farias, JW; Furtado, FS; Guimarães, SB; Silva Filho, AR; Vasconcelos, PR1
Algara López, M; Fernández-Velilla Cepria, E; Foro Arnalot, P; Lacruz Bassols, M; Lozano Galán, J; Membrive Conejo, I; Quera Jordana, J; Reig Castillejo, A; Rodríguez de Dios, N; Sanz Latiesas, J1
Geater, A; Laohawiriyakamol, S; Pradutkanchana, J; Puttawibul, P; Raungkhajorn, P; Ruangsin, S; Sangthawan, D; Sunpaweravong, P; Sunpaweravong, S1
Fujii, C; Fujino, M; Fukunaga, M; Hachino, Y; Hamaguchi, Y; Imamura, H; Iseki, C; Ishizaka, T; Kamigaki, S; Kawabata, R; Kawase, T; Kimura, Y; Yamamoto, E1
Aihara, M; Asakura, M; Furukita, Y; Goto, M; Harada, N; Mawatari, K; Minato, T; Nakaya, Y; Nishino, T; Seike, J; Takechi, H; Takizawa, H; Tangoku, A; Yamai, H; Yamamoto, Y; Yoshida, T; Yuasa, Y1
Alhamed, A; Chatterjee, A; Foster, DA; Hosny, C; Mukhopadhyay, S; Saqcena, M1
Akagi, Y; Matono, K; Ogata, Y; Shirouzu, K; Tsuda, H; Uchida, S; Ushijima, M1
Amsellem, C; Assenat, E; Bachmann, P; Collin, F; Courraud, J; Cristiani, I; de Forges, H; Dechelotte, P; Janiszewski, C; Khemissa, F; Mineur, L; Ramdani, M; Senesse, P1
Chen, X; Cheng, J; Huang, G; Liu, C; Liu, X; Peng, Z; Yu, F; Yuan, C1
Hong, D; Hong, KM; Kang, JH; Kim, SY; Lee, JS; Lee, SH; Son, J; Song, J1
Ferdous, T; Harada, K; Kobayashi, H; Ueyama, Y1
Bian, X; Chan, LS; Chen, H; Gou, H; Ji, F; Kang, W; Li, W; Liu, D; Qian, Y; Shirasawa, S; Sung, JJ; Wong, CC; Wu, JL; Xu, J; Yat Luk, ST; Yu, J; Zhou, Q1
Al-Taie, A; Koseoglu, A1
Almorsy, WA; Arab, HH; Kabel, AM; Khafagy, ES; Naguib, TM; Sabry, NM1

Reviews

2 review(s) available for glutamine and fluorouracil

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
BIOCHEMISTRY OF CANCER (METABOLIC ASPECTS).
    Annual review of biochemistry, 1963, Volume: 32

    Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Azaserine; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; Floxuridine; Fluorouracil; Folic Acid; Glutamine; Leukemia L1210; Mercaptopurine; Methotrexate; Mitomycin; Neoplasms; Neoplasms, Experimental; Pharmacology; Purines; Puromycin; Pyrimidines; Research; RNA; RNA, Neoplasm; Thioguanine; Thiouracil

1963

Trials

16 trial(s) available for glutamine and fluorouracil

ArticleYear
5-fluorouracil and folinic acid-induced mucositis: no effect of oral glutamine supplementation.
    British journal of cancer, 1994, Volume: 70, Issue:4

    Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Cross-Over Studies; Double-Blind Method; Feasibility Studies; Female; Fluorouracil; Gastrointestinal Neoplasms; Glutamine; Humans; Leucovorin; Male; Mouth Mucosa; Pilot Projects; Stomatitis

1994
Oral glutamine to prevent chemotherapy induced stomatitis: a pilot study.
    The Journal of laboratory and clinical medicine, 1996, Volume: 127, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carboplatin; Cyclophosphamide; Dacarbazine; Double-Blind Method; Doxorubicin; Etoposide; Female; Fluorouracil; Glutamine; Humans; Ifosfamide; Male; Neoplasms; Pilot Projects; Placebos; Sarcoma, Kaposi; Stomatitis; Vincristine

1996
Effects of glutamine supplements and radiochemotherapy on systemic immune and gut barrier function in patients with advanced esophageal cancer.
    Annals of surgery, 1998, Volume: 227, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Membrane Permeability; Cisplatin; Combined Modality Therapy; Dietary Supplements; Esophageal Neoplasms; Female; Fluorouracil; Glutamine; Humans; Indicators and Reagents; Intestinal Mucosa; Intestines; Lymphocyte Activation; Lymphocyte Count; Male; Middle Aged; Phenolsulfonphthalein; Radiation-Sensitizing Agents

1998
Phase III controlled evaluation of glutamine for decreasing stomatitis in patients receiving fluorouracil (5-FU)-based chemotherapy.
    American journal of clinical oncology, 1999, Volume: 22, Issue:3

    Topics: Administration, Oral; Administration, Topical; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Female; Fluorouracil; Glutamine; Humans; Male; Middle Aged; Mouthwashes; Stomatitis

1999
Reduction of chemotherapy-induced side-effects by parenteral glutamine supplementation in patients with metastatic colorectal cancer.
    European journal of cancer (Oxford, England : 1990), 1999, Volume: 35, Issue:2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Fluorouracil; Glutamine; Humans; Infusions, Parenteral; Intestinal Mucosa; Leucovorin; Male; Middle Aged; Prospective Studies

1999
Oral glutamine in the prevention of fluorouracil induced intestinal toxicity: a double blind, placebo controlled, randomised trial.
    Gut, 2001, Volume: 48, Issue:1

    Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Colonic Neoplasms; Diarrhea; Double-Blind Method; Female; Fluorouracil; Glutamine; Humans; Intestinal Absorption; Male; Middle Aged; Statistics, Nonparametric

2001
A phase II trial of irinotecan, 5-fluorouracil and leucovorin combined with celecoxib and glutamine as first-line therapy for advanced colorectal cancer.
    Oncology, 2005, Volume: 69, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Celecoxib; Colorectal Neoplasms; Cyclooxygenase Inhibitors; Diarrhea; Disease-Free Survival; Drug Administration Schedule; Female; Fluorouracil; Glutamine; Humans; Irinotecan; Leucovorin; Male; Middle Aged; Pyrazoles; Sulfonamides; Treatment Outcome

2005
The effect of oral glutamine on 5-fluorouracil/leucovorin-induced mucositis/stomatitis assessed by intestinal permeability test.
    Clinical nutrition (Edinburgh, Scotland), 2007, Volume: 26, Issue:1

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chromium Radioisotopes; Edetic Acid; Female; Fluorouracil; Glutamine; Humans; Intestinal Absorption; Leucovorin; Male; Middle Aged; Mucositis; Neoplasms; Permeability; Severity of Illness Index; Stomatitis; Treatment Outcome

2007
Oral glutamine is effective for preventing oxaliplatin-induced neuropathy in colorectal cancer patients.
    The oncologist, 2007, Volume: 12, Issue:3

    Topics: Adenocarcinoma; Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Chi-Square Distribution; Colorectal Neoplasms; Female; Fluorouracil; Glutamine; Humans; Leucovorin; Male; Middle Aged; Nervous System Diseases; Neuroprotective Agents; Organoplatinum Compounds; Oxaliplatin; Pilot Projects; Treatment Outcome

2007
Oral glutamine supplementation during preoperative radiochemotherapy in patients with rectal cancer: a randomised double blinded, placebo controlled pilot study.
    Clinical nutrition (Edinburgh, Scotland), 2011, Volume: 30, Issue:5

    Topics: Aged; Antimetabolites, Antineoplastic; Capecitabine; Chemical Phenomena; Chemoradiotherapy, Adjuvant; Deoxycytidine; Diarrhea; Dietary Supplements; Double-Blind Method; Female; Fluorouracil; Gastrointestinal Tract; Glutamine; Humans; Incidence; Male; Middle Aged; Patient Dropouts; Pilot Projects; Preoperative Period; Rectal Neoplasms; Severity of Illness Index

2011
Oxidative stress parameters in women with breast cancer undergoing neoadjuvant chemotherapy and treated with nutraceutical doses of oral glutamine.
    Acta cirurgica brasileira, 2011, Volume: 26 Suppl 1

    Topics: Administration, Oral; Adult; Aged; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Ductal, Breast; Cyclophosphamide; Double-Blind Method; Doxorubicin; Female; Fluorouracil; Glutamine; Glutathione; Humans; Middle Aged; Neoadjuvant Therapy; Oxidative Stress; Prospective Studies; Statistics, Nonparametric; Thiobarbituric Acid Reactive Substances; Time Factors

2011
Randomized study of antiinflammatory and immune-modulatory effects of enteral immunonutrition during concurrent chemoradiotherapy for esophageal cancer.
    Nutrition and cancer, 2014, Volume: 66, Issue:1

    Topics: Adult; Aged; Arginine; C-Reactive Protein; Carcinoma, Squamous Cell; Chemoradiotherapy; Cisplatin; Enteral Nutrition; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Fatty Acids, Omega-3; Female; Fluorouracil; Glutamine; Humans; Immunity, Cellular; Inflammation Mediators; Interferon-gamma; Interleukin-10; Interleukin-6; Male; Middle Aged; Tumor Necrosis Factor-alpha; Young Adult

2014
Randomized phase II study of 5-fluorouracil hepatic arterial infusion with or without antineoplastons as an adjuvant therapy after hepatectomy for liver metastases from colorectal cancer.
    PloS one, 2015, Volume: 10, Issue:3

    Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Benzeneacetamides; Chemotherapy, Adjuvant; Colorectal Neoplasms; Drug Combinations; Fluorouracil; Glutamine; Hepatectomy; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Middle Aged; Phenylacetates; Piperidones; Survival Analysis; Treatment Outcome

2015
A phase III study evaluating oral glutamine and transforming growth factor-beta 2 on chemotherapy-induced toxicity in patients with digestive neoplasm.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2016, Volume: 48, Issue:3

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cachexia; Dietary Supplements; Double-Blind Method; Female; Fluorouracil; Gastrointestinal Diseases; Gastrointestinal Neoplasms; Glutamine; Humans; Male; Middle Aged; Platinum Compounds; Transforming Growth Factor beta

2016
Potential therapeutic effects of different mouthwashes for alleviation and treatment of oral complications of 5-fluorouracil-based chemotherapy in patients with colon cancer.
    European journal of hospital pharmacy : science and practice, 2023, Volume: 30, Issue:4

    Topics: Benzydamine; Colonic Neoplasms; Fluorouracil; Glutamine; Humans; Mouthwashes; Pain; Prospective Studies; Quality of Life; Sodium Bicarbonate; Stomatitis; Xerostomia

2023
Ameliorative Potential of L-Alanyl L-Glutamine Dipeptide in Colon Cancer Patients Receiving Modified FOLFOX-6 Regarding the Incidence of Diarrhea, the Treatment Response, and Patients' Survival: A Randomized Controlled Trial.
    Medicina (Kaunas, Lithuania), 2022, Mar-07, Volume: 58, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Diarrhea; Dipeptides; Fluorouracil; Glutamine; Humans; Incidence; Leucovorin; Organoplatinum Compounds; Quality of Life

2022

Other Studies

21 other study(ies) available for glutamine and fluorouracil

ArticleYear
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Possibilities for a role of L-glutamine and L-asparagine antagonists in the treatment of gastrointestinal cancer.
    Cancer treatment reports, 1979, Volume: 63, Issue:6

    Topics: Animals; Asparagine; Azo Compounds; Drug Therapy, Combination; Fluorouracil; Gastrointestinal Neoplasms; Glutamine; Humans; Leukemia L1210; Mice; Tryptophan

1979
Genetical and biochemical evidence that a novel dinucleoside polyphosphate coordinates salvage and de novo nucleotide biosynthetic pathways in mammalian cells.
    Biochemical and biophysical research communications, 1977, Jan-10, Volume: 74, Issue:1

    Topics: Azaserine; Cell Line; Fluorouracil; Genes; Glutamine; Guanosine Triphosphate; Methotrexate; Mutation; Oligonucleotides; Oligoribonucleotides; Ribonucleotides

1977
Miscoding caused by 5-fluorouracil.
    Journal of molecular biology, 1969, Sep-14, Volume: 44, Issue:2

    Topics: Alkaline Phosphatase; Amino Acids; Base Sequence; Coliphages; Culture Media; Escherichia coli; Fluorouracil; Genetic Code; Glutamine; Mutation; Peptides; Phenotype; Protein Denaturation; Trypsin

1969
Antiglycolytic activities of 5-fluorouracil and related pyrimidines in mouse ascites carcinoma cells with special reference to inorganic phosphate and glucose.
    Oncology, 1969, Volume: 23, Issue:1

    Topics: Adenine; Animals; Arsenic; Carcinoma, Ehrlich Tumor; Carcinoma, Krebs 2; Deoxyuridine; Fluorouracil; Fructose; Glucose; Glutamine; Glycolysis; In Vitro Techniques; Manometry; Mice; Nucleosides; Phenols; Phosphates; Pyrimidines; Pyruvates; Respiration; Succinates; Uracil; Uridine

1969
Extracellular glutamine level reduction enhances 5-fluorouracil cytotoxicity.
    Cancer biochemistry biophysics, 1998, Volume: 16, Issue:1-2

    Topics: Amino Acids; Animals; Asparagine; Cell Count; Dose-Response Relationship, Drug; Fluorouracil; Glutamine; Humans; Leukemia; Leukemia P388; Methotrexate; Mice; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured

1998
GLUTAMINE SYNTHETASE. 3. FACTORS CONTROLLING ITS ACTIVITY IN THE DEVELOPING RAT.
    Archives of biochemistry and biophysics, 1964, Jul-20, Volume: 106

    Topics: Amino Acids; Ammonium Compounds; Animals; Animals, Newborn; Azaguanine; Brain; Dactinomycin; Ethionine; Fluorouracil; Glutamate-Ammonia Ligase; Glutamates; Glutamine; Humans; Hydrocortisone; Kidney; Lactates; Ligases; Liver; Male; Nucleosides; Pharmacology; Phenylalanine; Puromycin; Quaternary Ammonium Compounds; Rats; Research; Testis; Thiouracil; Thyroxine

1964
Glutamine and alanyl-glutamine accelerate the recovery from 5-fluorouracil-induced experimental oral mucositis in hamster.
    Cancer chemotherapy and pharmacology, 2008, Volume: 61, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Cricetinae; Dipeptides; Fluorouracil; Glutamine; Glutathione; Male; Mesocricetus; Mouth Mucosa; Neutrophil Infiltration; Peroxidase; Stomatitis; Sulfhydryl Compounds

2008
Alanyl-glutamine and glutamine supplementation improves 5-fluorouracil-induced intestinal epithelium damage in vitro.
    Digestive diseases and sciences, 2008, Volume: 53, Issue:10

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Line; Cell Movement; Cell Proliferation; Dipeptides; Dose-Response Relationship, Drug; Fluorouracil; Glutamine; Intestinal Mucosa; Jejunum; Models, Animal; Rats; Time Factors

2008
Single and combined supplementation of glutamine and n-3 polyunsaturated fatty acids on host tolerance and tumour response to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin (CPT-11)/5-fluorouracil chemotherapy in rats bearing Ward colo
    The British journal of nutrition, 2009, Volume: 102, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Body Weight; Camptothecin; Colonic Neoplasms; Combined Modality Therapy; Diarrhea; Dietary Supplements; Fatty Acids, Omega-3; Female; Fluorouracil; Glutamine; Immune Tolerance; Irinotecan; Leukocyte Count; Nutritional Status; Rats; Rats, Inbred F344; Treatment Failure; Xenograft Model Antitumor Assays

2009
Protective effects of amifostine and cyclooxygenase-1 inhibitor against normal human epidermal keratinocyte toxicity induced by methotrexate and 5-fluorouracil.
    Basic & clinical pharmacology & toxicology, 2009, Volume: 105, Issue:1

    Topics: Allopurinol; Amifostine; Antimetabolites, Antineoplastic; Calcium; Cell Line; Cell Proliferation; Cell Survival; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Interactions; Fibroblasts; Fluorouracil; Free Radical Scavengers; Glutamine; Humans; Keratinocytes; Methotrexate; Periodontal Ligament; Protective Agents; Pyrazoles; Reactive Oxygen Species; Stomatitis

2009
The bioenergetic signature of isogenic colon cancer cells predicts the cell death response to treatment with 3-bromopyruvate, iodoacetate or 5-fluorouracil.
    Journal of translational medicine, 2011, Feb-08, Volume: 9

    Topics: Adenosine Triphosphate; Blotting, Western; Cell Death; Colonic Neoplasms; Energy Metabolism; Fluorouracil; Glutamine; HCT116 Cells; Humans; Iodoacetates; Pyruvates; Remission Induction; Signal Transduction

2011
Prevention of acute radiation enteritis: efficacy and tolerance of glutamine.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2011, Volume: 13, Issue:10

    Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Cisplatin; Diarrhea; Female; Fluorouracil; Glutamine; Humans; Male; Maximum Tolerated Dose; Middle Aged; Pelvic Neoplasms; Prognosis; Prospective Studies; Quality of Life

2011
[Efficacy of AboundTM for hand-foot syndrome caused by capecitabine].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2013, Volume: 40, Issue:12

    Topics: Aged; Antimetabolites, Antineoplastic; Arginine; Butyrates; Capecitabine; Deoxycytidine; Female; Fluorouracil; Glutamine; Hand-Foot Syndrome; Humans; Hydroxy Acids; Male; Middle Aged; Neoplasms

2013
Glutamine protects the small intestinal mucosa in anticancer drug-induced rat enteritis model.
    The journal of medical investigation : JMI, 2014, Volume: 61, Issue:1-2

    Topics: Administration, Oral; Amine Oxidase (Copper-Containing); Animals; Antineoplastic Agents; Dietary Fiber; Disease Models, Animal; Enteritis; Fluorouracil; Glutamine; Immunoglobulin A; Intestinal Mucosa; Jejunum; Male; Oligosaccharides; Rats; Rats, Sprague-Dawley

2014
Blocking anaplerotic entry of glutamine into the TCA cycle sensitizes K-Ras mutant cancer cells to cytotoxic drugs.
    Oncogene, 2015, May-14, Volume: 34, Issue:20

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Capecitabine; Cell Cycle Checkpoints; Cell Line, Tumor; Citric Acid Cycle; Cytotoxins; Deoxycytidine; Fluorouracil; Glutamine; Humans; Mutation; Neoplasms; Paclitaxel; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins

2015
Clinical and therapeutic significance of sirtuin-4 expression in colorectal cancer.
    Oncology reports, 2016, Volume: 35, Issue:5

    Topics: Aged; Animals; Antimetabolites, Antineoplastic; Cell Survival; Colorectal Neoplasms; Drug Resistance, Neoplasm; Female; Fluorouracil; Gene Expression; Glutamine; HT29 Cells; Humans; Inhibitory Concentration 50; Kaplan-Meier Estimate; Male; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Mitochondrial Proteins; Multivariate Analysis; Neoplasm Transplantation; Prognosis; Proportional Hazards Models; Sirtuins

2016
Dual targeting of glutaminase 1 and thymidylate synthase elicits death synergistically in NSCLC.
    Cell death & disease, 2016, 12-08, Volume: 7, Issue:12

    Topics: A549 Cells; Adenosine Triphosphate; Animals; Aspartic Acid; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Death; Cell Proliferation; Cell Survival; Cytosol; Drug Synergism; Fluorouracil; Gene Knockdown Techniques; Glutamic Acid; Glutaminase; Glutamine; Lung Neoplasms; Malates; Mice, Inbred BALB C; Mice, Nude; Molecular Targeted Therapy; NAD; Oxidation-Reduction; Sulfides; Thiadiazoles; Thymidylate Synthase; Xenograft Model Antitumor Assays

2016
Elemental Diet Accelerates the Recovery From Oral Mucositis and Dermatitis Induced by 5-Fluorouracil Through the Induction of Fibroblast Growth Factor 2.
    Integrative cancer therapies, 2018, Volume: 17, Issue:2

    Topics: Animals; Dermatitis; Female; Fibroblast Growth Factor 2; Fluorouracil; Food, Formulated; Glutamine; Japan; Male; Mesocricetus; Mice; Mice, Nude; Skin; Stomatitis

2018
In Colorectal Cancer Cells With Mutant KRAS, SLC25A22-Mediated Glutaminolysis Reduces DNA Demethylation to Increase WNT Signaling, Stemness, and Drug Resistance.
    Gastroenterology, 2020, Volume: 159, Issue:6

    Topics: Animals; Colon; Colorectal Neoplasms; DNA Demethylation; Drug Resistance, Neoplasm; Female; Fluorouracil; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glutamine; Hong Kong; Humans; Intestinal Mucosa; Kaplan-Meier Estimate; Ketoglutaric Acids; Male; Mice, Knockout; Mitochondrial Membrane Transport Proteins; Neoplastic Stem Cells; Proto-Oncogene Proteins p21(ras); Wnt Signaling Pathway; Xenograft Model Antitumor Assays

2020