glutamine has been researched along with ascorbic acid in 44 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 13 (29.55) | 18.7374 |
1990's | 5 (11.36) | 18.2507 |
2000's | 7 (15.91) | 29.6817 |
2010's | 16 (36.36) | 24.3611 |
2020's | 3 (6.82) | 2.80 |
Authors | Studies |
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Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Roseman, S; Umbreit, J | 1 |
Richheimer, SL; Robinson, AB | 1 |
Brodie, AF; Kalra, VK; Prasad, R | 1 |
Yin, DZ | 1 |
Bito, LZ; Roberts, JC | 1 |
Bauer, M; Schirardin, H; Warter, J | 1 |
Cowell, JL | 1 |
Barnes, EM; Kaback, HR; Konings, WN | 1 |
Robinson, AB; Rudd, CJ | 1 |
Kameyama, T; Kinemuchi, H | 1 |
Gross, E; Van Campen, D | 1 |
Bradley, JF; Burns, J; Fallon, A; O'D McGee, J | 1 |
Grant, JP | 1 |
Antunes, LM; Cecchi, AO; Takahashi, CS; Tavares, DC | 1 |
Cantù, AM; Carpaneto, A; Gambale, F | 1 |
Ding, M; Dixon, SJ; Eliasson, C; Hamberger, A; Pekna, M; Pekny, M; Siushansian, R; Wilson, JX | 1 |
Burmeister, WP; Cottaz, S; Henrissat, B; Rollin, P; Vasella, A | 1 |
FERRARI, A; UBOLDI, L | 1 |
Alteheld, B; Deska, T; Haaker, R; Hummel, T; Senkal, M; Stehle, P; Steinfort, C; Zumtobel, V | 1 |
Chang, HX; Dong, LZ; Duan, CM; E, LL; Guo, XM; Jiang, H; Li, J; Song, Y; Wang, CY; Yang, XJ; Zhang, XA; Zhao, YS | 1 |
Akobeng, AK; Miller, V; Richmond, K; Thomas, AG | 1 |
Andrews, MT; Drewes, LR; Gruetter, R; Henry, PG; Russeth, KP; Tkac, I | 1 |
Akerström, TC; Pedersen, BK | 1 |
CHRISTENSEN, HN; LYNCH, EL | 1 |
Mayles, WJ; Sandoval, PA; Weitzel, LR; Wischmeyer, PE | 1 |
González-Ramírez, M; González-Trujano, ME; Orozco-Suarez, S; Razo-Juárez, LI; Salgado-Ceballos, H; Sauer-Ramírez, JL | 1 |
Duncan, HD; Jethwa, P; Johns, T; Kumar, S; Pearce, CB; Sodergren, MH | 1 |
Acuña, AI; Angulo, C; Beltrán, FA; Castro, MA; Concha, II; Miró, MP | 1 |
Cotton, BA; Reddell, L | 1 |
Blass, SC; Burger, C; Ellinger, S; Goost, H; Kabir, K; Stehle, P; Stoffel-Wagner, B; Tolba, RH | 1 |
Almeida, JR; Araújo, VR; Barberino, RS; Barros, VR; Matos, MH; Menezes, VG; Palheta, RC; Queiroz, MA; Santos, LP | 1 |
Akagi, M; Akagi, R; Hatori, Y; Inouye, S | 1 |
Cross, M; Hacker, MC; Lohrenz, A; Savkovic, V; Schneider, M; Simon, JC | 1 |
Abe, K; Hishikawa, N; Huang, Y; Liu, X; Morihara, R; Ohta, Y; Sato, K; Shang, J; Shi, X; Takemoto, M; Yamashita, T | 2 |
Andrulewicz-Botulinska, E; Hlebowicz-Sarat, K; Karna, E; Palka, JA; Szoka, L | 1 |
Braissant, O; Cudalbu, C; Grosse, J; McLin, VA; Pierzchala, K; Rackayová, V | 1 |
Abe, K; Deguchi, K; Higashi, Y; Hishikawa, N; Inufusa, H; Kawano, S; Kutoku, Y; Manabe, Y; Matsumoto, N; Morihara, R; Morimoto, N; Nakano, Y; Nomura, E; Ohta, Y; Sasaki, R; Sunada, Y; Tadokoro, K; Takahashi, Y; Takao, Y; Takemoto, M; Taomoto, K; Ueno, S; von Greiffenclau, MM; Wakutani, Y; Yamashita, T; Yoshikawa, T; You, F | 1 |
Al-Nawas, B; Bache, M; Bull, F; Eckert, AW; Grosse, I; Güttler, A; Kappler, M; Kaune, T; Kotrba, J; Krohn, K; Pabst, U; Porsch, M; Riemann, A; Rot, S; Schubert, J; Seliger, B; Taubert, H; Thews, O; Vordermark, D; Weinholdt, C; Wickenhauser, C | 1 |
De Waele, E; Malbrain, MLNG; Spapen, H | 1 |
Accinni, R; Beretta, A; Biswas, P; Dellanoce, C; Malnati, M; Mrakic-Sposta, S; Vezzoli, A | 1 |
Hasenzahl, M; Mertsch, S; Müsken, M; Reichl, S; Schrader, S | 1 |
6 review(s) available for glutamine and ascorbic acid
Article | Year |
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DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Deamidation of glutaminyl and asparaginyl residues in peptides and proteins.
Topics: Aging; Amides; Amino Acid Sequence; Animals; Ascorbic Acid; Asparagine; Bacterial Proteins; Biological Evolution; Cytochrome c Group; Escherichia coli; Fructose-Bisphosphate Aldolase; Glutamine; Histones; Humans; Hydrogen-Ion Concentration; Hydrolysis; Muramidase; Oxygen; Peptides; Proteins; Temperature | 1974 |
Nutritional support in critically ill patients.
Topics: Albumins; Amino Acids; Arginine; Ascorbic Acid; Critical Illness; Fatty Acids; Glutamine; Humans; Nucleotides; Nutritional Support; Vitamin E | 1994 |
Effects of pharmaconutrients on cellular dysfunction and the microcirculation in critical illness.
Topics: Animals; Antioxidants; Arginine; Ascorbic Acid; Cells; Critical Illness; Fatty Acids, Omega-3; Glutamine; Heat-Shock Proteins; Humans; Inflammation; Microcirculation; Micronutrients; Selenium; Zinc | 2009 |
Antioxidants and micronutrient supplementation in trauma patients.
Topics: Antioxidants; Arginine; Ascorbic Acid; Critical Illness; Cystine; Dietary Supplements; Fatty Acids; Glutamine; Humans; Intensive Care Units; Micronutrients; Oxidative Stress; Selenium; Zinc | 2012 |
Nutrition in Sepsis: A Bench-to-Bedside Review.
Topics: Ascorbic Acid; Critical Care; Critical Illness; Enteral Nutrition; Fatty Acids, Omega-3; Glutamine; Humans; Nutrition Therapy; Nutritional Requirements; Nutritional Support; Parenteral Nutrition; Sepsis | 2020 |
5 trial(s) available for glutamine and ascorbic acid
Article | Year |
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Effect of exclusive enteral nutritional treatment on plasma antioxidant concentrations in childhood Crohn's disease.
Topics: Adolescent; Antioxidants; Ascorbic Acid; Child; Crohn Disease; Double-Blind Method; Enteral Nutrition; Female; Glutamine; Glutathione; Humans; Male; Malondialdehyde; Oxidative Stress; Selenium; Uric Acid; Vitamin A; Vitamin E | 2007 |
Immunonutrition in patients undergoing major upper gastrointestinal surgery: a prospective double-blind randomised controlled study.
Topics: Aged; Amino Acids; Arginine; Ascorbic Acid; C-Reactive Protein; Chromium; Digestive System Surgical Procedures; Double-Blind Method; Energy Intake; Enteral Nutrition; Fatty Acids, Omega-3; Female; Glutamine; Humans; Length of Stay; Male; Micronutrients; Middle Aged; Postoperative Care; Prospective Studies; Retinol-Binding Proteins; Selenium; Triglycerides; Zinc | 2010 |
Time to wound closure in trauma patients with disorders in wound healing is shortened by supplements containing antioxidant micronutrients and glutamine: a PRCT.
Topics: Adult; Aged; alpha-Tocopherol; Antioxidants; Ascorbic Acid; beta Carotene; Dietary Supplements; Double-Blind Method; Female; Glutamine; Humans; Male; Micronutrients; Middle Aged; Selenium; Vascular Endothelial Growth Factor A; Wound Healing; Zinc | 2012 |
Clinical Benefits of Antioxidative Supplement Twendee X for Mild Cognitive Impairment: A Multicenter, Randomized, Double-Blind, and Placebo-Controlled Prospective Interventional Study.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Antioxidants; Ascorbic Acid; Cognition; Cognitive Dysfunction; Cystine; Dietary Supplements; Double-Blind Method; Female; Glutamine; Humans; Male; Mental Status and Dementia Tests; Prospective Studies; Treatment Outcome | 2019 |
Antioxidant Activity with Increased Endogenous Levels of Vitamin C, E and A Following Dietary Supplementation with a Combination of Glutathione and Resveratrol Precursors.
Topics: Acetylcysteine; Aged; Alanine; Antioxidants; Ascorbic Acid; Dietary Supplements; Erythrocytes; Female; Glucosides; Glutamine; Glutathione; Glycine; Humans; Ketoglutaric Acids; Male; Middle Aged; Neopterin; Oxidation-Reduction; Resveratrol; Stilbenes; Sulfhydryl Compounds; Vitamin A; Vitamin E; Vitamins | 2020 |
33 other study(ies) available for glutamine and ascorbic acid
Article | Year |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Effect of maternal age on intercellular adhesion of embryonic chick liver cells.
Topics: Animals; Ascorbic Acid; Cell Adhesion; Chick Embryo; Chickens; Female; Glutamine; Humans; Liver; Maternal Age | 1976 |
Instability and function: ascorbic acid and glutaminyl and asparaginyl residues.
Topics: Ascorbic Acid; Asparagine; Binding Sites; Chemical Phenomena; Chemistry; Glutamine; Peptides; Protein Binding; Proteins; Transferrin | 1975 |
Active transport of glutamine and glutamic acid in membrane vesicles from Mycobacterium phlei.
Topics: Antimetabolites; Ascorbic Acid; Biological Transport, Active; Cell Membrane; Electron Transport; Glutamates; Glutamine; Kinetics; Mycobacterium; Mycobacterium phlei; Proline; Tetramethylphenylenediamine; Time Factors | 1975 |
Lipofuscin-like fluorophores can result from reactions between oxidized ascorbic acid and glutamine. Carbonyl-protein cross-linking may represent a common reaction in oxygen radical and glycosylation-related ageing processes.
Topics: Aging; Ascorbic Acid; Cross-Linking Reagents; Fluorescent Dyes; Free Radicals; Glutamine; Glycosylation; Hydrogen-Ion Concentration; In Vitro Techniques; Lipofuscin; Oxidation-Reduction; Schiff Bases | 1992 |
The effects of hibernation on the chemical composition of cerebrospinal and intraocular fluids, blood plasma and brain tissue of the woodchuck (Marmota monax).
Topics: Amino Acids; Animals; Ascorbic Acid; Biological Transport, Active; Blood; Blood-Brain Barrier; Body Fluids; Brain; Calcium; Cerebrospinal Fluid; Eye; Glucose; Glutamates; Glutamine; Hibernation; Lactates; Magnesium; Osmolar Concentration; Potassium; Proteins; Rodentia; Sodium; Water | 1974 |
[Action of ascorbic acid on ammoniemia, alpha-ketoglutaric acid, glutamic acid and glutamine in cirrhotic and normal subjects].
Topics: Ammonia; Ascorbic Acid; Glutamates; Glutamine; Humans; Ketoglutaric Acids; Liver Cirrhosis | 1967 |
Energetics of glycylglycine transport in Escherichia coli.
Topics: Adenosine Triphosphatases; Anaerobiosis; Arsenic; Ascorbic Acid; Biological Transport, Active; Calcium; Carbon Radioisotopes; Cell Membrane; Chloramphenicol; Dipeptides; Escherichia coli; Glucose; Glutamine; Glycylglycine; Lactates; Magnesium; Models, Chemical; Mutation; Osmosis; Proline; Succinates; Uncoupling Agents | 1974 |
Mechanisms of active transport in isolated membrane vesicles. 2. The coupling of reduced phenazine methosulfate to the concentrative uptake of beta-galactosides and amino acids.
Topics: Amino Acids; Amobarbital; Ascorbic Acid; Bacillus megaterium; Bacillus subtilis; Biological Transport, Active; Cell Membrane; Chloromercuribenzoates; Cyanides; Cyclic N-Oxides; Electron Transport; Escherichia coli; Glutamine; Lactose; Lysine; NAD; Oxygen; Phenazines; Proline; Proteus; Pseudomonas; Quinolines; Salmonella typhimurium; Stimulation, Chemical; Sulfuric Acids | 1971 |
[Effect of substances related to catecholamine on free amino acids and ammonium in the brain under cold stress].
Topics: Adrenal Glands; Aminobutyrates; Ammonia; Animals; Ascorbic Acid; Aspartic Acid; Brain; Brain Chemistry; Cold Temperature; Dihydroxyphenylalanine; Glutamates; Glutamine; Hydrazines; Male; Monoamine Oxidase Inhibitors; Nialamide; Rats; Stress, Physiological | 1967 |
Effect of histidine and certain other amino acids on the absorption of iron-59 by rats.
Topics: Amino Acids; Animals; Ascorbic Acid; Duodenum; Glutamates; Glutamine; Glycine; Histidine; Intestinal Absorption; Iron; Iron Isotopes; Lysine; Male; Methionine; Rats | 1969 |
Collagen stimulating factors in hepatic fibrogenesis.
Topics: Animals; Ascorbic Acid; Cell Line; Chromatography, Gel; Collagen; DNA; Fibroblasts; Glutamine; Humans; Liver; Liver Cirrhosis; Male; Mice; Procollagen-Proline Dioxygenase; Protein Biosynthesis; Tissue Extracts | 1984 |
Protective effects of the amino acid glutamine and of ascorbic acid against chromosomal damage induced by doxorubicin in mammalian cells.
Topics: Animals; Antibiotics, Antineoplastic; Ascorbic Acid; CHO Cells; Chromosome Aberrations; Cricetinae; Doxorubicin; Female; Glutamine; Male; Rats; Rats, Wistar | 1998 |
Redox agents regulate ion channel activity in vacuoles from higher plant cells.
Topics: Ascorbic Acid; Biological Transport; Chloramines; Dithiothreitol; Glutamine; Ion Channel Gating; Ion Channels; Kinetics; Mercaptoethanol; Oxidants; Oxidation-Reduction; Patch-Clamp Techniques; Plant Cells; Plant Leaves; Plant Proteins; Plant Roots; Plants; Reducing Agents; Sulfhydryl Compounds; Tosyl Compounds; Vacuoles | 1999 |
The impact of genetic removal of GFAP and/or vimentin on glutamine levels and transport of glucose and ascorbate in astrocytes.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Ascorbic Acid; Astrocytes; Biological Transport; Bucladesine; Cells, Cultured; Cyclic AMP; Glial Fibrillary Acidic Protein; Glucose; Glutamine; Ion Channels; Mice; Mice, Inbred C57BL; Vimentin | 1999 |
High resolution X-ray crystallography shows that ascorbate is a cofactor for myrosinase and substitutes for the function of the catalytic base.
Topics: Ascorbic Acid; Binding Sites; Carboxylic Acids; Catalysis; Crystallography, X-Ray; Glucosinolates; Glutamine; Glycoside Hydrolases; Hydrolysis; Kinetics; Lactams; Models, Chemical; Models, Molecular; Mustard Plant; Plants, Medicinal; Protein Binding; Protein Conformation; Sulfates; Time Factors | 2000 |
[Relations between ascorbic acid and the hepatic synthesis of glutamine].
Topics: Ascorbic Acid; Glutamine; Liver; Vitamins | 1960 |
Early enteral gut feeding with conditionally indispensable pharmaconutrients is metabolically safe and is well tolerated in postoperative cancer patients--a pilot study.
Topics: Aged; Ascorbic Acid; Enteral Nutrition; Female; Food, Formulated; Gastrointestinal Neoplasms; Glutamine; Humans; Jejunostomy; Male; Pilot Projects; Postoperative Care; Prospective Studies; Time Factors; Treatment Outcome; Vitamin E; Zinc | 2004 |
Creation of engineered cardiac tissue in vitro from mouse embryonic stem cells.
Topics: Animals; Ascorbic Acid; Cell Differentiation; Cells, Cultured; Collagen; Collagen Type I; Drug Combinations; Embryo, Mammalian; Glutamine; Implants, Experimental; Laminin; Mercaptoethanol; Mice; Mice, Nude; Myocardial Contraction; Myocytes, Cardiac; Organoids; Proteoglycans; Stem Cells; Stress, Mechanical; Tissue Engineering | 2006 |
Brain energy metabolism and neurotransmission at near-freezing temperatures: in vivo (1)H MRS study of a hibernating mammal.
Topics: Animals; Ascorbic Acid; Aspartic Acid; Brain; Brain Chemistry; Choline; Cold Temperature; Creatine; Energy Metabolism; Ethanolamines; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Glutathione; Hibernation; Inositol; Lactic Acid; Magnetic Resonance Spectroscopy; Phosphocreatine; Sciuridae; Synaptic Transmission; Taurine | 2007 |
Strategies to enhance immune function for marathon runners : what can be done?
Topics: Ascorbic Acid; Colostrum; Denmark; Dietary Supplements; Glucose; Glutamine; Humans; Respiratory Tract Infections; Running | 2007 |
Decrease of glycine and glutamine in skeletal muscle and of glutamine in liver in ascorbic acid deficiency in the guinea pig.
Topics: Ascorbic Acid; Ascorbic Acid Deficiency; Glutamine; Glycine; Guinea Pigs; Humans; Liver; Muscle, Skeletal; Muscles | 1948 |
Anticonvulsive effect of vitamin C on pentylenetetrazol-induced seizures in immature rats.
Topics: Animals; Anticonvulsants; Ascorbic Acid; Aspartic Acid; Brain Chemistry; Chromatography, High Pressure Liquid; Convulsants; Dose-Response Relationship, Drug; Epilepsies, Myoclonic; Epilepsy, Tonic-Clonic; Female; gamma-Aminobutyric Acid; Glutamates; Glutamine; Male; Pentylenetetrazole; Progesterone; Rats; Rats, Sprague-Dawley; Seizures; Vitamins | 2010 |
Ascorbic acid-dependent GLUT3 inhibition is a critical step for switching neuronal metabolism.
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Ascorbic Acid; Astrocytes; Cell Line, Tumor; Cerebral Cortex; Deoxyglucose; Dose-Response Relationship, Drug; Glioma; Glucose Transporter Type 3; Glutamine; Kinetics; Microscopy, Confocal; Neurons; Rats; Rats, Wistar; Recombinant Proteins; RNA Interference; Transfection | 2011 |
Amburana cearensis leaf extract maintains survival and promotes in vitro development of ovine secondary follicles.
Topics: Animals; Ascorbic Acid; Cattle; Cell Proliferation; Cell Shape; Cell Survival; Cells, Cultured; Fabaceae; Female; Glutamine; Hypoxanthine; Insulin; Ovarian Follicle; Plant Extracts; Plant Leaves; Selenium; Serum Albumin, Bovine; Sheep; Transferrin | 2016 |
Prevention of Barrier Disruption by Heme Oxygenase-1 in Intestinal Bleeding Model.
Topics: Ascorbic Acid; Caco-2 Cells; Gastrointestinal Hemorrhage; Glutamine; Heme Oxygenase-1; Hemin; Humans; Intestinal Mucosa; Malondialdehyde; Metalloporphyrins | 2016 |
A human serum-enriched medium formulation supports high viability and marker expression in primary melanocyte cultures from the outer root sheath and epidermis.
Topics: Animals; Ascorbic Acid; Calcium Chloride; Cattle; Cell Proliferation; Cell Survival; Cells, Cultured; Culture Media; Epidermal Cells; Epidermis; Epinephrine; Fibroblast Growth Factors; Glutamine; Hair Follicle; Humans; Insulin; Melanins; Melanocytes; Phenotype; Primary Cell Culture; Serum | 2018 |
Clinical and Pathological Benefit of Twendee X in Alzheimer's Disease Transgenic Mice with Chronic Cerebral Hypoperfusion.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Behavior, Animal; Brain; Cerebrovascular Circulation; Cerebrovascular Disorders; Chronic Disease; Cognition; Cystine; Dietary Supplements; Disease Models, Animal; Female; Glutamine; Inflammation Mediators; Male; Mice, Inbred C57BL; Mice, Transgenic; Motor Activity; Mutation; Neuroprotective Agents; Oxidative Stress; Plaque, Amyloid | 2019 |
The mechanism for differential effect of nelfinavir and indinavir on collagen metabolism in human skin fibroblasts.
Topics: Acetylcysteine; Ascorbic Acid; Cell Survival; Collagen; Dipeptidases; DNA; Down-Regulation; Fibroblasts; Glutamine; HIV Protease Inhibitors; Humans; Indinavir; Nelfinavir; NF-kappa B p50 Subunit; Phosphatidylinositol 3-Kinases; Phosphorylation; Proline; Skin; Wortmannin | 2019 |
Longitudinal neurometabolic changes in the hippocampus of a rat model of chronic hepatic encephalopathy.
Topics: Ammonium Compounds; Animals; Ascorbic Acid; Astrocytes; Chronic Disease; Creatine; Disease Models, Animal; Glutamine; Hepatic Encephalopathy; Hippocampus; Male; Oxidative Stress; Proton Magnetic Resonance Spectroscopy; Rats; Rats, Wistar | 2019 |
Twendee X Ameliorates Phosphorylated Tau, α-Synuclein and Neurovascular Dysfunction in Alzheimer's Disease Transgenic Mice With Chronic Cerebral Hypoperfusion.
Topics: alpha-Synuclein; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Antioxidants; Ascorbic Acid; Brain; Cerebrovascular Disorders; Cystine; Dietary Supplements; Disease Models, Animal; Female; Genetic Predisposition to Disease; Glutamine; Male; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neurovascular Coupling; Phenotype; Phosphorylation; tau Proteins | 2019 |
Causes and Consequences of A Glutamine Induced Normoxic HIF1 Activity for the Tumor Metabolism.
Topics: Acetylation; Ascorbic Acid; Carbonic Anhydrase IX; Cell Line, Tumor; Energy Metabolism; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glutamine; Glycolysis; High-Throughput Nucleotide Sequencing; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Neoplasms; Protein Stability; RNA, Small Interfering | 2019 |
Cell sheet technology: Influence of culture conditions on in vitro-cultivated corneal stromal tissue for regenerative therapies of the ocular surface.
Topics: Ascorbic Acid; Biocompatible Materials; Cell Culture Techniques; Cell Proliferation; Corneal Stroma; Culture Media; Extracellular Matrix; Fibroblasts; Glutamine; Glycine; Humans; Hydroxyproline; Proline; Regeneration; Serum Albumin, Bovine; Surface Properties; Tensile Strength; Tissue Engineering; Tissue Scaffolds; Transforming Growth Factor beta1 | 2021 |