glutaminase has been researched along with ammonium-acetate* in 3 studies
3 other study(ies) available for glutaminase and ammonium-acetate
| Article | Year |
|---|---|
Rat cerebral mitochondrial glutaminase activity is unaffected by moderate hyperammonemia in two models.
The phosphate-dependent (PAG) and phosphate-independent (PIndG) glutaminase activities were measured in cerebral perikaryal mitochondria derived from rats subjected to ammonium acetate- induced "simple" hyperammonemia (SHA) or thioacetamide-induced hepatic encephalopathy (HE). These two moderately hyperammonemic conditions were previously found to be accompanied by pronounced changes in virtually all the enzyme activities coupling the tricarboxylic acid cycle to the synthesis and metabolism of the excitatory neurotransmitter glutamate. Both PAG and PIndG remained unaffected by SHA or HE, indicating that they do not contribute to the cerebral glutamine/glutamate imbalance associated with both conditions. Topics: Acetates; Animals; Brain; Citric Acid Cycle; Glutaminase; Hepatic Encephalopathy; Male; Mitochondria; Phosphates; Rats; Rats, Wistar; Thioacetamide | 1996 |
Hyperammonemic alterations in the metabolism of glutamate and aspartate in rat cerebellar astrocytes.
Pathophysiological concentrations of ammonia, both in vivo and in vitro, suppressed the production of 14CO2 from 14C-labelled glutamate and aspartate in astrocytes isolated from the rat cerebellum. Suppression of 14CO2 production with (aminooxy)acetic acid but not with glutamic acid diethyl ester indicated that transamination plays a major role in the oxidation of glutamate carbons. Activities of the enzymes, aspartate amino-transferase, alanine aminotransferase and glutaminase were decreased while those of glutamate dehydrogenase and glutamine synthetase were enhanced in the cerebellar astrocytes during hyperammonemic states. These results suggest an impairment of astrocytic glutamate metabolism during hyperammonemia. Topics: Acetates; Alanine Transaminase; Aminooxyacetic Acid; Animals; Aspartate Aminotransferases; Aspartic Acid; Astrocytes; Carbon Radioisotopes; Cerebellum; Excitatory Amino Acid Antagonists; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamates; Glutaminase; In Vitro Techniques; Rats; Rats, Wistar; Reference Values | 1992 |
Changes in the levels of glutamate and related amino acids in the intact and decorticated rat neostriatum during various conditions associated with convulsions.
Topics: 2-Amino-5-phosphonovalerate; Acetates; Amino Acids; Animals; Anticonvulsants; Brain Mapping; Caudate Nucleus; Cerebral Cortex; Cerebral Decortication; Corpus Striatum; Electroencephalography; Epilepsy, Tonic-Clonic; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutaminase; Hypoglycemia; Insulin; Male; Methionine Sulfoximine; Penicillin G; Putamen; Rats; Rats, Wistar; Seizures; Synaptic Transmission | 1992 |