glutaminase has been researched along with 3-aminopicolinic-acid* in 1 studies
1 other study(ies) available for glutaminase and 3-aminopicolinic-acid
| Article | Year |
|---|---|
Evidence that 3-aminopicolinate stimulates glutamine metabolism by rat renal cortical tissue in vitro.
The hyperglycemic agent 3-aminopicolinate used at concentrations of 0.05 and 0.1 mM stimulates the removal of 5 mM glutamine. It also stimulates the accumulation of glutamate and the formation of ammonia, glucose and aspartate by isolated rat kidney-cortex tubules. These effects are consistent with a stimulation of glutaminase and an inhibition of phosphoenolpyruvate carboxy-kinase by this compound. Higher concentrations (0.5 and 1 mM) of 3-aminopicolinate fail to affect the removal of 5 mM glutamine, but greatly alter the fate of both glutamine carbon and amino nitrogen. Similar effects of 3-aminopicolinate are observed when glutamine is used at a near-physiological concentration. Topics: Animals; Enzyme Activation; Glutaminase; Glutamine; In Vitro Techniques; Kidney Cortex; Kidney Tubules; Male; Picolinic Acids; Rats | 1982 |