Compounds > glutamic acid

glutamic acid and quinolinic acid

glutamic acid has been researched along with quinolinic acid in 101 studies

Research

Studies (101)

TimeframeStudies, this research(%)All Research%
pre-199018 (17.82)18.7374
1990's34 (33.66)18.2507
2000's24 (23.76)29.6817
2010's22 (21.78)24.3611
2020's3 (2.97)2.80

Authors

AuthorsStudies
Bigge, CF; Drummond, JT; Humblet, C; Johnson, G; Malone, TC; Ortwine, DF; Pinter, GW1
DiFiglia, M; Finklestein, SP; Freese, A1
Alesiani, M; Ciuffi, M; Facci, L; Fadda, E; Galli, A; Lombardi, G; Mori, F; Moroni, F; Natalini, B; Skaper, SD1
Berretta, S; Graybiel, AM; Robertson, HA1
Beal, MF; Finn, SF; Kowall, NW; Mazurek, MF; Swartz, KJ1
Papachristou, DN; Patel, SC; Patel, YC1
Beaton, JA; Monaghan, DT1
Ford, LM; Norman, AB; Sanberg, PR1
Du, F; Schwarcz, R1
Lu, YM; Qin, YF; Zhang, JT; Zhao, FQ1
Rios, C; Santamaria, A1
Keilhoff, G; Schmidt, W; Stastný, F; Wolf, G1
Beal, MF; DiFiglia, M; Freese, A; Koroshetz, WJ; Martin, JB1
Khaspekov, LG; Lisý, V; Stastný, F; Viktorov, IV1
Meguri, H; Ogita, K; Ohgaki, T; Uchida, S; Yoneda, Y1
Collins, JF; Meldrum, BS; Turski, L1
Connick, JH; Stone, TW2
Cotman, CW; Ganong, AH1
Aleksandrov, VG; Lapin, IP; Mandel'shtam, IuE; Ryzhov, IV; Slepokurov, MV1
Addae, JI; Stone, TW1
Wieloch, T1
Choi, DW; Koh, JY; Peters, S1
Fonnum, F; Fosse, VM1
Ben-Ari, Y; Schwarcz, R1
Connick, JH; English, M; Hastings, MH; Stone, TW; Winn, P1
Davies, SW; Roberts, PJ1
Samanin, R; Vezzani, A; Wu, HQ1
Choi, DW; Peters, S1
Boegman, RJ; Parent, A1
Dousa, TP; Kempson, SA; Ou, SY1
Contestabile, A; Migani, P; Poli, A; Villani, L1
Brown, CS; Chen, Q; Harris, C; Howe, A; Reiner, A; Surmeier, DJ1
Henschke, G; Wolf, G; Würdig, S1
Alberch, J; Arenas, E; Marsal, J; Pérez-Navarro, E1
Mennini, T; Miari, A; Presti, ML; Rizzi, M; Samanin, R; Vezzani, A1
Dvoráková, L; Lisý, V; Stastný, F1
Keilhoff, G; Wolf, G1
Frim, DM; Isacson, O; Pakzaban, P; Uhler, TA1
Marshall, JF; McPherson, RJ; O'Dell, SJ; Weihmuller, FB1
Fedele, E; Foster, AC1
Friedemann, MN; Gerhardt, GA1
Bochet, P; de Carvalho, LP; Rossier, J1
Bradley, WG; Nagano, I; Nakamura, S; Shapshak, P; Srivastava, AK; Stewart, RV; Xin, KQ; Yoshioka, M1
Mary, V; Stutzmann, JM; Wahl, F1
Furtado, JC; Garside, S; Mazurek, MF1
Chaudhri, G; Hunt, NH; Moore, DE; Sanni, LA; Stocker, R; Tattam, BN; Thomas, SR1
Basile, AS; Fossom, L; Goping, G; Sei, Y; Skolnick, P1
Keilhoff, G; Reinheckel, T; Seidel, B; Wolf, G1
Hinoi, E; Ogita, K; St'astny, F; Yoneda, Y1
Battaglia, G; Bruno, V; Flor, PJ; Gasparini, F; Hess, SD; Inderbitzin, W; Johnson, EC; Kuhn, R; Laurie, D; Leonhardt, T; Lukic, S; Nicoletti, F; Portet, C; Sauer, D; Schmutz, M; Sommer, B; Urwyler, S; Varney, MA1
Brum, LF; Elisabetsky, E; Souza, DO1
Dutra-Filho, CS; Santos, CE; Souza, DO; Tasca, CI; Tavares, RG; Wajner, M1
da Silveira Perla, A; de Faria Maraschin, J; Lara, DR; Onofre Souza, D; Schmidt, AP1
Baran, H; Gille, L; Kepplinger, B; Nohl, H; Staniek, K; Stolze, K1
Baraldi, M; Cannazza, G; Zanoli, P1
Burgos, JS; Frizzo, ME; Lara, DR; Ramírez, G; Schmidt, AP; Souza, DO1
Daya, S; Heron, P1
Domenici, MR; Falchi, M; Frank, C; Malchiodi-Albedi, F; Massotti, M; Pèzzola, A; Pintor, A; Popoli, P; Quarta, D; Reggio, R; Scarchilli, L; Tebano, MT1
Alves, LB; Emanuelli, T; Porciúncula, LO; Santos, CE; Souza, DO; Tasca, CI; Tavares, RG1
Lisý, V; Stastný, F1
Corsi, C; Gianfriddo, M; Melani, A; Pedata, F; Pèzzola, A; Popoli, P; Reggio, R1
Domenici, MR; Frank, C; Nazzicone, V; Pèzzola, A; Pintor, A; Popoli, P; Potenza, RL; Reggio, R; Tebano, MT1
De Berardinis, MA; Domenici, MR; Frank, C; Grieco, R; Martire, A; Massotti, M; Minghetti, L; Nazzicone, V; Pepponi, R; Pèzzola, A; Pintor, A; Popoli, P; Potenza, RL; Reggio, R; Tebano, MT1
Domenici, MR; Frank, C; Grieco, R; Martire, A; Pepponi, R; Pintor, A; Popoli, P; Potenza, RL; Tebano, MT1
de Oliveira, DL; Frizzo, ME; Horn, JF; Moriguchi, E; Rodrigues, JM; Souza, DO; Wofchuk, S1
Domenici, MR; Massotti, M; Minghetti, L; Pintor, A; Popoli, P; Tebano, MT1
Bantubungi, K; Blum, D; Brotchi, J; Brouillet, E; Chtarto, A; Déglon, N; Galas, MC; Greco, A; Jacquard, C; Levivier, M; Minghetti, L; Pintor, A; Popoli, P; Schiffmann, SN; Tai, K; Tenenbaum, L1
da Costa, F; de Oliveira, DL; Perry, ML; Scheibel, F; Schweigert, ID; Souza, DO; Wofchuk, ST1
Abud, J; Schmidt, AP; Souza, DO; Tasca, CI; Tavares, RG1
Guidetti, P; Poeggeler, B; Rassoulpour, A; Roberts, RC; Schwarcz, R; Wu, HQ1
Schmidt, AP; Souza, DO; Tasca, CI; Tavares, RG1
Borsini, F; Galluzzo, M; Grieco, R; Pèzzola, A; Pintor, A; Popoli, P1
Alves, D; Avila, DS; Colle, D; Gubert, P; Nogueira, CW; Palma, A; Rocha, JB; Soares, FA1
Dilović, I; Gliubich, F; Malpeli, G; Matković-Calogović, D; Zanotti, G1
Fülöp, F; Klivényi, P; Toldi, J; Vámos, E; Vécsei, L; Zádori, D1
Bennouar, KE; Beurrier, C; Bonvento, G; Escartin, C; Faideau, M; Gubellini, P; Kerkerian-Le Goff, L1
Adams, S; Brew, BJ; Chung, R; Guillemin, GJ; Lee, MC; Ting, KK1
Muller, Gdo A; Severino, PC; Tasca, CI; Vandresen-Filho, S1
Bernstein, HG; Bielau, H; Bogerts, B; Brisch, R; Gos, T; Guillemin, GJ; Mawrin, C; Meyer zu Schwabedissen, L; Myint, AM; Sarnyai, Z; Steiner, J; Walter, M1
Bastos, LL; Bridi, JC; Corte, CL; da Rocha, JB; de Ávila, DS; Dobrachinski, F; Soares, FA1
Han, R; Liang, ZQ; Qin, S; Qin, ZH; Wang, Y; Wang, YR; Wu, JC1
An, SC; Chen, HB; Li, F; Wu, S1
Dantzer, R; Walker, AK1
Bertoldo, DB; Dal-Cim, T; Maraschin, M; Martins, WC; Tasca, CI; Vandresen-Filho, S; Zeni, AL1
Bernstein, HG; Bogerts, B; Busse, S; Dobrowolny, H; Gos, T; Mawrin, C; Meyer-Lotz, G; Müller, UJ; Myint, AM; Schiltz, K; Steiner, J1
Bertoldo, DB; Constantino, LC; Dal-Cim, T; Martins, WC; Molz, S; Severino, PC; Silva, FR; Tasca, CI; Vandresen-Filho, S1
Kumar, P; Singh, S1
Bertoldo, DB; Leal, RB; Maestri, M; Martins, WC; Rieger, DK; Tasca, CI; Vandresen-Filho, S1
Candelario-Jalil, E; de Oliveira, AC; Fiebich, BL; Saliba, SW; Santos, RP; Teixeira, AL; Vieira, EL; Vieira, LB1
Deshmukh, R; Gill, JS; Jamwal, S; Kumar, P1
Parasram, K1
Benjamins, JA; Lisak, RP; Nedelkoska, L1
Klivényi, P; Szalárdy, L; Vécsei, L; Veres, G; Zádori, D1
Arantes, LP; Aschner, M; Câmara, DF; da Silva, TC; da Silveira, TL; Machado, ML; Santamaría, A; Soares, FAA; Zamberlan, DC1
Caso, JR; García-Bueno, B; Leza, JC; Madrigal, JLM; Martín-Hernández, D; Tendilla-Beltrán, H1
Alavi, MS; Barzegar, H; Fanoudi, S; Fard, AV; Hosseini, M; Sadeghnia, HR; Soukhtanloo, M1
Chi, T; Ji, X; Li, Y; Liu, D; Liu, H; Liu, P; Qi, X; Xu, J; Zou, L1
Antunes Soares, FA; Aschner, M; Bicca Obetine Baptista, F; Duarte Hartmann, D; Farina Gonçalves, D; Franzen da Silva, A; Lenz Dalla Corte, C; Limana da Silveira, T; Lopes Machado, M; Marafiga Cordeiro, L1
Chen, Q; Chen, W; Kong, Q; Mao, X; Wang, G; Zhang, H; Zhao, J1
Chen, J; Chen, X; He, S; Huang, Y; Li, G; Li, H; Liu, L; Meng, X; Ou, J; Zhang, W; Zhao, Z; Zhou, J1

Reviews

13 review(s) available for glutamic acid and quinolinic acid

ArticleYear
Quinolinic acid and kynurenic acid in the mammalian brain.
    Advances in experimental medicine and biology, 1991, Volume: 294

    Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; AIDS Dementia Complex; Animals; Aspartic Acid; Biological Transport; Brain Chemistry; Brain Diseases; Dioxygenases; Epilepsy, Temporal Lobe; Glutamates; Glutamic Acid; Humans; Kynurenic Acid; Kynurenine; Lyases; Nerve Degeneration; Oxygenases; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, Neurotransmitter; Transaminases

1991
Quinolinic acid and other kynurenines in the central nervous system.
    Neuroscience, 1985, Volume: 15, Issue:3

    Topics: Animals; Blood-Brain Barrier; Brain; Brain Chemistry; Convulsants; Glutamates; Glutamic Acid; Hippocampus; Humans; In Vitro Techniques; Kynurenine; Neurotransmitter Agents; Pipecolic Acids; Quinolinic Acid; Quinolinic Acids; Rats; Retina; Synapses; Synaptic Transmission; Tryptophan Oxygenase

1985
Neurochemical correlates to selective neuronal vulnerability.
    Progress in brain research, 1985, Volume: 63

    Topics: Adenosine; Afferent Pathways; Animals; Aspartic Acid; Brain Diseases; Brain Ischemia; Calcium; Chlorides; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Hypoglycemia; Models, Biological; Neural Inhibition; Neurochemistry; Neurons; Neurotransmitter Agents; Norepinephrine; Parasympathomimetics; Quinolinic Acid; Quinolinic Acids; Rats

1985
Endogenous excitotoxic agents.
    Ciba Foundation symposium, 1987, Volume: 126

    Topics: Animals; Aspartic Acid; Cell Survival; Central Nervous System; Dementia; Epilepsy; Glutamates; Glutamic Acid; Humans; Huntington Disease; Models, Neurological; Neurons; Quinolinic Acid; Quinolinic Acids

1987
Excitatory receptors and their role in excitotoxicity.
    Biochemical Society transactions, 1987, Volume: 15, Issue:2

    Topics: Aminobutyrates; Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Humans; N-Methylaspartate; Neurons; Quinolinic Acid; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter

1987
Recent advances in the use of selective neuron-destroying agents for neurobiological research.
    Experientia, 1984, Jun-15, Volume: 40, Issue:6

    Topics: Animals; Aziridines; Choline; Colchicine; Folic Acid; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Lectins; Mitogens; Mustard Compounds; Nerve Degeneration; Nervous System; Neurons; Piperidines; Pyrrolidonecarboxylic Acid; Quinolinic Acid; Quinolinic Acids

1984
Role of immune activation and cytokine expression in HIV-1-associated neurologic diseases.
    Advances in neuroimmunology, 1995, Volume: 5, Issue:3

    Topics: AIDS Dementia Complex; Apoptosis; Cell Adhesion; Cytokines; Endothelium, Vascular; Glutamic Acid; HIV Envelope Protein gp120; HIV Infections; HIV-1; Humans; Lymphocyte Subsets; Macrophages; Neuroglia; Neurons; Nitric Oxide; Peripheral Nervous System Diseases; Quinolinic Acid; Receptors, Glutamate

1995
Adenosine A2A receptor antagonism and neuroprotection: mechanisms, lights, and shadows.
    Critical reviews in neurobiology, 2004, Volume: 16, Issue:1-2

    Topics: Adenosine A2 Receptor Antagonists; Animals; Brain Chemistry; Glutamic Acid; Humans; Neuroprotective Agents; Oxidative Stress; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Stimulation, Chemical

2004
Kynurenines in chronic neurodegenerative disorders: future therapeutic strategies.
    Journal of neural transmission (Vienna, Austria : 1996), 2009, Volume: 116, Issue:11

    Topics: Animals; Brain; Glutamic Acid; Humans; Kynurenic Acid; Mitochondrial Diseases; NAD; Neurodegenerative Diseases; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinolinic Acid; Tryptophan

2009
Cell signaling in NMDA preconditioning and neuroprotection in convulsions induced by quinolinic acid.
    Life sciences, 2011, Oct-10, Volume: 89, Issue:15-16

    Topics: Animals; Brain; Brain Chemistry; Cerebrovascular Circulation; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; Ischemic Preconditioning; N-Methylaspartate; Neuroprotective Agents; Neurotoxicity Syndromes; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic P1; Seizures; Signal Transduction

2011
Is there a role for glutamate-mediated excitotoxicity in inflammation-induced depression?
    Journal of neural transmission (Vienna, Austria : 1996), 2014, Volume: 121, Issue:8

    Topics: Animals; Blood-Brain Barrier; Depressive Disorder; Glutamic Acid; Humans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation; Kynurenine; Neuroimmunomodulation; Quinolinic Acid

2014
Phytochemical treatments target kynurenine pathway induced oxidative stress.
    Redox report : communications in free radical research, 2018, Volume: 23, Issue:1

    Topics: Animals; Disease Models, Animal; Glutamic Acid; Humans; Kynurenine; Neurodegenerative Diseases; Neuroprotective Agents; Oxidative Stress; Phytochemicals; Plant Extracts; Quinolinic Acid; Tryptophan

2018
Alzheimer's Disease: Recent Concepts on the Relation of Mitochondrial Disturbances, Excitotoxicity, Neuroinflammation, and Kynurenines.
    Journal of Alzheimer's disease : JAD, 2018, Volume: 62, Issue:2

    Topics: Alzheimer Disease; Animals; Central Nervous System; Disease Models, Animal; Energy Metabolism; Glutamic Acid; Humans; Immunity, Innate; Inflammation; Kynurenine; Mitochondria; Quinolinic Acid; Reactive Oxygen Species; Receptors, Glutamate; Signal Transduction

2018

Other Studies

88 other study(ies) available for glutamic acid and quinolinic acid

ArticleYear
Generation of N-methyl-D-aspartate agonist and competitive antagonist pharmacophore models. Design and synthesis of phosphonoalkyl-substituted tetrahydroisoquinolines as novel antagonists.
    Journal of medicinal chemistry, 1992, Apr-17, Volume: 35, Issue:8

    Topics: Binding, Competitive; Isoquinolines; Models, Molecular; Molecular Conformation; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship

1992
Basic fibroblast growth factor protects striatal neurons in vitro from NMDA-receptor mediated excitotoxicity.
    Brain research, 1992, Mar-20, Volume: 575, Issue:2

    Topics: Animals; Cell Death; Corpus Striatum; Fibroblast Growth Factor 2; Glutamates; Glutamic Acid; Kainic Acid; Nervous System Diseases; Neurons; Neurotoxins; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate

1992
Thiokynurenates prevent excitotoxic neuronal death in vitro and in vivo by acting as glycine antagonists and as inhibitors of lipid peroxidation.
    European journal of pharmacology, 1992, Jul-21, Volume: 218, Issue:1

    Topics: Animals; Cell Survival; Corpus Striatum; Glutamates; Glutamic Acid; Glycine; Kynurenic Acid; Lipid Peroxidation; Male; Neurons; Quinolinic Acid; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate

1992
Dopamine and glutamate agonists stimulate neuron-specific expression of Fos-like protein in the striatum.
    Journal of neurophysiology, 1992, Volume: 68, Issue:3

    Topics: Amphetamine; Animals; Biogenic Monoamines; Cocaine; Corpus Striatum; Dopamine Agents; Glutamates; Glutamic Acid; Interneurons; Male; Neurons; Proto-Oncogene Proteins c-fos; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Synaptic Transmission

1992
Neurochemical characterization of excitotoxin lesions in the cerebral cortex.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1991, Volume: 11, Issue:1

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Cerebral Cortex; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Homocysteine; Ibotenic Acid; Kainic Acid; Male; N-Methylaspartate; NADPH Dehydrogenase; Neuropeptides; Neurotoxins; Neurotransmitter Agents; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains

1991
Quinolinic acid stimulates somatostatin gene expression in cultured rat cortical neurons.
    Journal of neurochemistry, 1991, Volume: 56, Issue:4

    Topics: Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Gene Expression Regulation; Glutamates; Glutamic Acid; Neurons; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Somatostatin; Time Factors

1991
Quinolinate differentiates between forebrain and cerebellar NMDA receptors.
    European journal of pharmacology, 1991, Feb-26, Volume: 194, Issue:1

    Topics: Animals; Autoradiography; Binding, Competitive; Brain Chemistry; Cerebellum; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kinetics; N-Methylaspartate; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate

1991
Differential loss of neurochemical markers following quinolinic acid-induced lesions of rat striatum.
    Experimental neurology, 1991, Volume: 114, Issue:1

    Topics: Animals; Benzazepines; Biomarkers; Choline O-Acetyltransferase; Corpus Striatum; Dizocilpine Maleate; Glutamate Decarboxylase; Glutamates; Glutamic Acid; Male; Neurotoxins; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate

1991
Effects of Ca2+ antagonists on glutamate release and Ca2+ influx in the hippocampus with in vivo intracerebral microdialysis.
    British journal of pharmacology, 1991, Volume: 104, Issue:1

    Topics: Alkaloids; Animals; Benzylisoquinolines; Calcium; Calcium Channel Blockers; Calcium Channels; Dialysis; Female; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Neuromuscular Depolarizing Agents; Neurons; Neurotransmitter Agents; Nimodipine; Perfusion; Potassium Chloride; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Stereotaxic Techniques; Veratridine

1991
Quinolinic acid is a potent lipid peroxidant in rat brain homogenates.
    Neurochemical research, 1991, Volume: 16, Issue:10

    Topics: Analysis of Variance; Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Kainic Acid; Kynurenic Acid; Kynurenine; Lipid Peroxidation; Male; Malondialdehyde; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Thiobarbiturates

1991
Quinolinate neurotoxicity and glutamatergic structures.
    Neuroscience, 1990, Volume: 34, Issue:1

    Topics: Age Factors; Animals; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Hippocampus; Injections, Intraventricular; Ketamine; Kynurenic Acid; Male; Neurotoxins; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains

1990
Characterization and mechanism of glutamate neurotoxicity in primary striatal cultures.
    Brain research, 1990, Jun-25, Volume: 521, Issue:1-2

    Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Cells, Cultured; Corpus Striatum; Glutamates; Glutamic Acid; Huntington Disease; Magnesium; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate

1990
Cytotoxic effect of glutamate and its agonists on mouse hippocampal neurons.
    Journal fur Hirnforschung, 1990, Volume: 31, Issue:5

    Topics: 2-Amino-5-phosphonovalerate; Animals; Cell Survival; Cells, Cultured; Dipeptides; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Female; Glutamates; Glutamic Acid; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Pregnancy; Quinolinic Acid; Quinolinic Acids

1990
N-methyl-D-aspartate-sensitive [3H]glutamate binding sites in brain synaptic membranes treated with Triton X-100.
    Biochimica et biophysica acta, 1989, Jun-15, Volume: 1012, Issue:1

    Topics: Amino Acids; Animals; Aspartic Acid; Binding, Competitive; Brain; Glutamates; Glutamic Acid; Kinetics; Kynurenic Acid; N-Methylaspartate; Octoxynol; Polyethylene Glycols; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Stereoisomerism; Structure-Activity Relationship; Synaptic Membranes; Temperature; Tissue Distribution

1989
Anticonvulsant action of beta-kainic acid in mice. Is beta-kainic acid an N-methyl-D-aspartate antagonist?
    Brain research, 1985, Jun-10, Volume: 336, Issue:1

    Topics: Animals; Anticonvulsants; Aspartic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; Homocysteine; Kainic Acid; Mice; N-Methylaspartate; Oxadiazoles; Pyrrolidines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid; Seizures; Stereoisomerism

1985
Kynurenic acid and quinolinic acid act at N-methyl-D-aspartate receptors in the rat hippocampus.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 236, Issue:1

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; N-Methylaspartate; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tetrodotoxin

1986
[Effect of excitant amino acid antagonists on glutamate receptors in the locust and on convulsions induced by glutamate, aspartate, kynurenine and quinolinic acid in mice].
    Biulleten' eksperimental'noi biologii i meditsiny, 1986, Volume: 101, Issue:3

    Topics: Alanine; Amino Acids; Aminobutyrates; Animals; Aspartic Acid; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Glutamates; Glutamic Acid; Grasshoppers; Kynurenine; Male; Membrane Potentials; Mice; Muscles; Pyridines; Quinolinic Acid; Quinolinic Acids; Receptors, Glutamate; Receptors, Neurotransmitter; Seizures

1986
Effects of topically applied excitatory amino acids on evoked potentials and single cell activity in rat cerebral cortex.
    European journal of pharmacology, 1986, Mar-04, Volume: 121, Issue:3

    Topics: Administration, Topical; Amino Acids; Animals; Aspartic Acid; Carbachol; Cerebral Cortex; Evoked Potentials, Somatosensory; Glutamates; Glutamic Acid; Homocysteine; In Vitro Techniques; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Tetrodotoxin

1986
Neurons containing NADPH-diaphorase are selectively resistant to quinolinate toxicity.
    Science (New York, N.Y.), 1986, Oct-03, Volume: 234, Issue:4772

    Topics: Animals; Aspartic Acid; Glutamates; Glutamic Acid; Humans; Huntington Disease; Kainic Acid; Mice; N-Methylaspartate; NADH, NADPH Oxidoreductases; NADPH Dehydrogenase; Neurons; Oxadiazoles; Pyridines; Quinolinic Acid; Quinolinic Acids; Quisqualic Acid

1986
The effect of kainic, quinolinic and beta-kainic acids on the release of endogenous amino acids from rat brain slices.
    Biochemical pharmacology, 1986, Oct-15, Volume: 35, Issue:20

    Topics: Amino Acids; Animals; Aspartic Acid; Brain; Calcium; Chromatography, High Pressure Liquid; Glutamates; Glutamic Acid; Kainic Acid; Magnesium; Male; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains

1986
Effects of kainic acid and other excitotoxins in the rat superior colliculus: relations to glutamatergic afferents.
    Brain research, 1986, Sep-24, Volume: 383, Issue:1-2

    Topics: Animals; Cholinergic Fibers; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Kainic Acid; Male; Neural Pathways; Neurotoxins; Quinolinic Acid; Quinolinic Acids; Rats; Superior Colliculi; Synaptic Transmission; Tetrahydrofolates

1986
Seizures and brain damage: are excitatory amino acids involved?
    Advances in experimental medicine and biology, 1986, Volume: 203

    Topics: Action Potentials; Amino Acids; Animals; Brain; Epilepsy; Glutamates; Glutamic Acid; Hippocampus; Nerve Degeneration; Neurotransmitter Agents; Quinolinic Acid; Quinolinic Acids; Seizures; Synaptic Transmission

1986
[3H]norepinephrine release from hippocampal slices is an in vitro biochemical tool for investigating the pharmacological properties of excitatory amino acid receptors.
    Journal of neurochemistry, 1987, Volume: 49, Issue:5

    Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dipeptides; Glutamates; Glutamic Acid; Hippocampus; Homocysteine; Kainic Acid; Magnesium; Male; N-Methylaspartate; Norepinephrine; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Tetrodotoxin

1987
Quinolinate is a weak excitant of cortical neurons in cell culture.
    Brain research, 1987, Sep-08, Volume: 420, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Magnesium; Membrane Potentials; Mice; Pyridines; Quinolinic Acid; Quinolinic Acids; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Valine

1987
The response of striatal neuropeptide Y and cholinergic neurons to excitatory amino acid agonists.
    Brain research, 1988, Jun-14, Volume: 452, Issue:1-2

    Topics: Acetylcholinesterase; Animals; Cerebral Decortication; Choline O-Acetyltransferase; Cholinergic Fibers; Corpus Striatum; Glutamates; Glutamic Acid; Kainic Acid; Male; Neuropeptide Y; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains

1988
Relationship between rate of gluconeogenesis and content of nicotinamide adenine dinucleotide in renal cortex.
    Life sciences, 1981, Sep-21, Volume: 29, Issue:12

    Topics: Animals; Cytosol; Gluconeogenesis; Glutamates; Glutamic Acid; In Vitro Techniques; Ketoglutaric Acids; Kidney Cortex; Kinetics; Male; NAD; Picolinic Acids; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains

1981
Glutamate-mediated excitotoxic death of cultured striatal neurons is mediated by non-NMDA receptors.
    Experimental neurology, 1995, Volume: 136, Issue:2

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Basal Ganglia; Cell Death; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Glutamic Acid; Kainic Acid; Nerve Degeneration; Pregnancy; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate

1995
Glutamate agonist-induced hippocampal lesion and nitric oxide synthase/NADPH-diaphorase: a light and electron microscopical study in the rat.
    Neuroscience letters, 1993, Oct-14, Volume: 161, Issue:1

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Oxidoreductases; Animals; Benzothiazoles; Brain Diseases; Glutamates; Glutamic Acid; Hippocampus; Microscopy, Electron; NADPH Dehydrogenase; Neurons; Nitric Oxide; Nitric Oxide Synthase; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tetrazolium Salts

1993
Selective resistance of tachykinin-responsive cholinergic neurons in the quinolinic acid lesioned neostriatum.
    Brain research, 1993, Feb-19, Volume: 603, Issue:2

    Topics: Acetylcholine; Animals; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Microinjections; Neostriatum; Neurokinin A; Neurons; Peptide Fragments; Potassium Chloride; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Substance P

1993
Adaptive changes in the NMDA receptor complex in rat hippocampus after chronic treatment with CGP 39551.
    European journal of pharmacology, 1994, Dec-12, Volume: 271, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Dizocilpine Maleate; Glutamic Acid; Hippocampus; Kynurenic Acid; Male; Norepinephrine; Phencyclidine; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate

1994
Altered glutamate binding following quinolinate lesions in developing rat brain.
    Experimental neurology, 1994, Volume: 125, Issue:1

    Topics: Animals; Animals, Newborn; Brain; Glutamates; Glutamic Acid; Injections, Intraventricular; Male; Quinolinic Acid; Rats; Rats, Wistar; Regression Analysis; Tissue Distribution

1994
Comparison of double fluorescence staining and LDH-test for monitoring cell viability in vitro.
    Neuroreport, 1993, Nov-18, Volume: 5, Issue:2

    Topics: Animals; Biomarkers; Cell Survival; Cells, Cultured; Cerebral Cortex; Culture Media, Conditioned; Cytological Techniques; Fluoresceins; Fluorescent Dyes; Glutamates; Glutamic Acid; Hydrolysis; Kainic Acid; L-Lactate Dehydrogenase; Microscopy, Fluorescence; N-Methylaspartate; Nerve Degeneration; Nerve Tissue Proteins; Neuroglia; Neurons; Neurotoxins; Propidium; Quinolinic Acid; Rats; Rats, Wistar

1993
The effects of megadose methylprednisolone and U-78517F on toxicity mediated by glutamate receptors in the rat neostriatum.
    Neurosurgery, 1994, Volume: 34, Issue:1

    Topics: Animals; Cell Survival; Chromans; Corpus Striatum; Dose-Response Relationship, Drug; Energy Metabolism; Free Radical Scavengers; Glutamates; Glutamic Acid; Lipid Peroxidation; Male; Methylprednisolone Hemisuccinate; Nerve Degeneration; Piperazines; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate

1994
Excitotoxic striatal lesions protect against subsequent methamphetamine-induced dopamine depletions.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 269, Issue:3

    Topics: Animals; Autoradiography; Corpus Striatum; Dopamine; Glutamates; Glutamic Acid; Male; Methamphetamine; Microdialysis; Quinolinic Acid; Rats; Rats, Sprague-Dawley

1994
An evaluation of the role of extracellular amino acids in the delayed neurodegeneration induced by quinolinic acid in the rat striatum.
    Neuroscience, 1993, Volume: 52, Issue:4

    Topics: Amino Acids; Animals; Asparagine; Aspartic Acid; Corpus Striatum; Dialysis; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Male; Microinjections; Nerve Degeneration; Niacin; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Serine; Threonine

1993
In vivo electrochemical studies of the dynamic effects of locally applied excitatory amino acids in the striatum of the anesthetized rat.
    Experimental neurology, 1996, Volume: 138, Issue:1

    Topics: Adolescent; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Corpus Striatum; Cricetinae; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acids; Glutamic Acid; Humans; Kainic Acid; Male; N-Methylaspartate; Oxidation-Reduction; Potassium; Quinolinic Acid; Quisqualic Acid; Rats; Rats, Sprague-Dawley

1996
The endogenous agonist quinolinic acid and the non endogenous homoquinolinic acid discriminate between NMDAR2 receptor subunits.
    Neurochemistry international, 1996, Volume: 28, Issue:4

    Topics: Animals; Cerebral Cortex; Female; Glutamic Acid; Glycine; Kainic Acid; Macromolecular Substances; Membrane Potentials; N-Methylaspartate; Nerve Tissue Proteins; Oocytes; Polymerase Chain Reaction; Quinolinic Acid; Quinolinic Acids; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; RNA, Messenger; Xenopus laevis

1996
Effect of riluzole on quinolinate-induced neuronal damage in rats: comparison with blockers of glutamatergic neurotransmission.
    Neuroscience letters, 1995, Dec-01, Volume: 201, Issue:1

    Topics: Animals; Anticonvulsants; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Lamotrigine; Male; Neurons; Quinolinic Acid; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Riluzole; Synaptic Transmission; Thiazoles; Triazines

1995
Dopamine-glutamate interactions in the striatum: behaviourally relevant modification of excitotoxicity by dopamine receptor-mediated mechanisms.
    Neuroscience, 1996, Volume: 75, Issue:4

    Topics: Analysis of Variance; Animals; Corpus Striatum; Dopamine; Functional Laterality; Glutamic Acid; Haloperidol; Male; Maze Learning; Motor Activity; Neurotoxins; Oxidopamine; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Dopamine D2; Substantia Nigra

1996
Dramatic changes in oxidative tryptophan metabolism along the kynurenine pathway in experimental cerebral and noncerebral malaria.
    The American journal of pathology, 1998, Volume: 152, Issue:2

    Topics: Animals; Aspartic Acid; Brain; Brain Diseases; Female; Glutamic Acid; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Kynurenine; Malaria; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Osmolar Concentration; Oxidation-Reduction; Quinolinic Acid; Tryptophan; Tryptophan Oxygenase

1998
Quinolinic acid protects rat cerebellar granule cells from glutamate-induced apoptosis.
    Neuroscience letters, 1998, Jan-30, Volume: 241, Issue:2-3

    Topics: Animals; Apoptosis; Cerebellum; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Logistic Models; N-Methylaspartate; Necrosis; Neurons; Neuroprotective Agents; Quinolinic Acid; Rats; Rats, Sprague-Dawley

1998
Differentially expressed genes in hippocampal cell cultures in response to an excitotoxic insult by quinolinic acid.
    Brain research. Molecular brain research, 1998, Oct-01, Volume: 60, Issue:2

    Topics: Amino Acid Sequence; Amyloid beta-Protein Precursor; Animals; Carrier Proteins; Cells, Cultured; Fetus; Gene Expression Regulation; Glutamic Acid; Hippocampus; Molecular Sequence Data; Neurons; Neurotoxins; Peptide Hydrolases; Platelet-Derived Growth Factor; Protease Nexins; Proteasome Endopeptidase Complex; Quinolinic Acid; Rats; Receptors, Cell Surface; RNA, Messenger; Sequence Alignment; Sequence Homology, Amino Acid; Transcription, Genetic; Zinc Fingers

1998
Ferrous iron modulates quinolinate-mediated [3H]MK-801 binding to rat brain synaptic membranes in the presence of glycine and spermidine.
    Neuroscience letters, 1999, Mar-05, Volume: 262, Issue:2

    Topics: 2-Amino-5-phosphonovalerate; Allosteric Regulation; Animals; Binding Sites; Brain; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Ferrous Compounds; Glutamic Acid; Glycine; Inhibitory Concentration 50; Kynurenic Acid; Male; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Synaptic Membranes

1999
(R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:3

    Topics: Animals; Anticonvulsants; Brain; Cell Line; Cell Membrane; Colforsin; Corpus Striatum; Cyclic AMP; Electroshock; Glutamic Acid; Glycine; Humans; Kinetics; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; Neuroprotective Agents; Phosphatidylinositols; Protein Isoforms; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Recombinant Proteins; Second Messenger Systems; Seizures; Structure-Activity Relationship

1999
Anticonvulsant properties of linalool in glutamate-related seizure models.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 1999, Volume: 6, Issue:2

    Topics: Acyclic Monoterpenes; Animals; Anticonvulsants; Cerebral Cortex; Disease Models, Animal; Dizocilpine Maleate; Glutamic Acid; Kindling, Neurologic; Male; Monoterpenes; N-Methylaspartate; Pentylenetetrazole; Phenobarbital; Quinolinic Acid; Radioligand Assay; Rats; Rats, Wistar; Seizures; Terpenes

1999
Quinolinic acid inhibits glutamate uptake into synaptic vesicles from rat brain.
    Neuroreport, 2000, Feb-07, Volume: 11, Issue:2

    Topics: Animals; Biological Transport; Brain; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Male; Quinolinic Acid; Rats; Rats, Wistar; Synaptic Vesicles

2000
Guanosine and GMP prevent seizures induced by quinolinic acid in mice.
    Brain research, 2000, May-02, Volume: 864, Issue:1

    Topics: Animals; Anticonvulsants; Central Nervous System; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Guanosine; Guanosine Monophosphate; Male; Mice; Neurons; Picrotoxin; Quinolinic Acid; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Receptors, Purinergic P1; Seizures; Time Factors

2000
Kynurenic acid influences the respiratory parameters of rat heart mitochondria.
    Pharmacology, 2001, Volume: 62, Issue:2

    Topics: Animals; Cell Respiration; Excitatory Amino Acid Antagonists; Glutamic Acid; Kynurenic Acid; Kynurenine; Malates; Male; Mitochondria, Heart; Oxygen Consumption; Quinolinic Acid; Rats; Rats, Sprague-Dawley

2001
Prenatal exposure to methyl mercury in rats: focus on changes in kynurenine pathway.
    Brain research bulletin, 2001, May-15, Volume: 55, Issue:2

    Topics: Animals; Aspartic Acid; Female; Fetus; Glutamic Acid; Hippocampus; Kynurenine; Mercury Poisoning, Nervous System; Methylmercury Compounds; Neurons; ortho-Aminobenzoates; Pregnancy; Prenatal Exposure Delayed Effects; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Tryptophan

2001
Effect of orally administered guanosine on seizures and death induced by glutamatergic agents.
    Brain research, 2001, Sep-07, Volume: 912, Issue:2

    Topics: Animals; Brain; Caffeine; Death; Dizocilpine Maleate; Dose-Response Relationship, Drug; Elapid Venoms; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Guanosine; Kainic Acid; Male; Mice; Neuroprotective Agents; Phenobarbital; Phosphodiesterase Inhibitors; Quinolinic Acid; Receptors, Purinergic P1

2001
17Beta-estradiol attenuates quinolinic acid insult in the rat hippocampus.
    Metabolic brain disease, 2001, Volume: 16, Issue:3-4

    Topics: Animals; Estradiol; Female; Glutamic Acid; Hippocampus; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate

2001
Blockade of striatal adenosine A2A receptor reduces, through a presynaptic mechanism, quinolinic acid-induced excitotoxicity: possible relevance to neuroprotective interventions in neurodegenerative diseases of the striatum.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Mar-01, Volume: 22, Issue:5

    Topics: Animals; Behavior, Animal; Calcium; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Excitatory Amino Acid Antagonists; Gliosis; Glutamic Acid; Hippocampus; Huntington Disease; Long-Term Potentiation; Male; Maze Learning; Motor Activity; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Presynaptic Terminals; Purinergic P1 Receptor Antagonists; Pyrimidines; Quinolinic Acid; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, Purinergic P1; Triazoles

2002
Quinolinic acid stimulates synaptosomal glutamate release and inhibits glutamate uptake into astrocytes.
    Neurochemistry international, 2002, Volume: 40, Issue:7

    Topics: Animals; Astrocytes; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; L-Lactate Dehydrogenase; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synaptosomes

2002
Nitric oxide synthase inhibition and glutamate binding in quinolinate-lesioned rat hippocampus.
    Physiological research, 2002, Volume: 51, Issue:3

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Cell Membrane; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Kainic Acid; Male; Molsidomine; N-Methylaspartate; Nerve Degeneration; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Quinolinic Acid; Quisqualic Acid; Rats; Rats, Wistar; Tritium

2002
Adenosine A(2A) antagonism increases striatal glutamate outflow in the quinolinic acid rat model of Huntington's disease.
    Brain research, 2003, Jul-25, Volume: 979, Issue:1-2

    Topics: Adenosine; Animals; Chromatography, High Pressure Liquid; Corpus Striatum; Extracellular Space; Glutamic Acid; Huntington Disease; Male; Microdialysis; Models, Animal; Neuroprotective Agents; Purinergic P1 Receptor Antagonists; Pyrimidines; Quinolinic Acid; Rats; Rats, Wistar; Receptor, Adenosine A2A; Time Factors; Triazoles

2003
Modulation of glutamate release and excitotoxicity by adenosine A2A receptors.
    Neurology, 2003, Dec-09, Volume: 61, Issue:11 Suppl 6

    Topics: Adenosine A2 Receptor Antagonists; Animals; Cells, Cultured; Corpus Striatum; Drug Administration Routes; Electric Stimulation; Electroencephalography; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Microdialysis; Motor Activity; Neurons; Neuroprotective Agents; Neurotoxins; Pyrimidines; Quinolinic Acid; Rats; Receptor, Adenosine A2A; Receptors, N-Methyl-D-Aspartate; Synapses; Triazoles

2003
Neuroprotective effects of the mGlu5R antagonist MPEP towards quinolinic acid-induced striatal toxicity: involvement of pre- and post-synaptic mechanisms and lack of direct NMDA blocking activity.
    Journal of neurochemistry, 2004, Volume: 89, Issue:6

    Topics: Animals; Body Weight; Calcium; Cells, Cultured; Electroencephalography; Excitatory Amino Acid Antagonists; Glutamic Acid; L-Lactate Dehydrogenase; Male; Maze Learning; Microdialysis; N-Methylaspartate; Neostriatum; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Neurotoxins; Pyridines; Quinolinic Acid; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate

2004
Adenosine A2A receptor blockade differentially influences excitotoxic mechanisms at pre- and postsynaptic sites in the rat striatum.
    Journal of neuroscience research, 2004, Jul-01, Volume: 77, Issue:1

    Topics: 4-Aminopyridine; Adenosine; Adenosine A2 Receptor Antagonists; Animals; Calcium; Corpus Striatum; Dose-Response Relationship, Drug; Glutamic Acid; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Models, Biological; N-Methylaspartate; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Phenethylamines; Pyrimidines; Quinolinic Acid; Rats; Rats, Wistar; Receptor, Adenosine A2A; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes; Synaptic Transmission; Triazines; Triazoles

2004
Quinolinic acid promotes seizures and decreases glutamate uptake in young rats: reversal by orally administered guanosine.
    Brain research, 2004, Aug-20, Volume: 1018, Issue:1

    Topics: Administration, Oral; Aging; Animals; Animals, Newborn; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Epilepsy; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; Glutamic Acid; Guanosine; In Vitro Techniques; Injections, Intraventricular; Male; Neurons; Phenobarbital; Picrotoxin; Quinolinic Acid; Rats; Rats, Wistar

2004
Minocycline in phenotypic models of Huntington's disease.
    Neurobiology of disease, 2005, Volume: 18, Issue:1

    Topics: Animals; Calpain; Caspases; Cell Death; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalitis; Glutamic Acid; Huntingtin Protein; Huntington Disease; Male; Minocycline; Nerve Degeneration; Nerve Tissue Proteins; Neuroprotective Agents; Nitro Compounds; Nuclear Proteins; Phenotype; Propionates; Quinolinic Acid; Rats; Rats, Inbred Lew; Rats, Wistar; Staurosporine

2005
Gestational and postnatal malnutrition affects sensitivity of young rats to picrotoxin and quinolinic acid and uptake of GABA by cortical and hippocampal slices.
    Brain research. Developmental brain research, 2005, Feb-08, Volume: 154, Issue:2

    Topics: Analysis of Variance; Animals; Animals, Newborn; Body Weight; Caseins; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Female; Fetal Nutrition Disorders; GABA Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; In Vitro Techniques; Lactation; Male; Picrotoxin; Pregnancy; Prenatal Nutritional Physiological Phenomena; Quinolinic Acid; Rats; Seizures; Time Factors; Tritium

2005
In vivo quinolinic acid increases synaptosomal glutamate release in rats: reversal by guanosine.
    Neurochemical research, 2005, Volume: 30, Issue:4

    Topics: Animals; Glutamic Acid; Guanosine; In Vitro Techniques; Injections, Intraperitoneal; Injections, Intraventricular; L-Lactate Dehydrogenase; Male; Nerve Tissue Proteins; Quinolinic Acid; Rats; Rats, Wistar; Seizures; Stimulation, Chemical; Synaptosomes

2005
Dopamine receptor activation reveals a novel, kynurenate-sensitive component of striatal N-methyl-D-aspartate neurotoxicity.
    Neuroscience, 2007, Aug-10, Volume: 148, Issue:1

    Topics: Animals; Astrocytes; Cell Death; Corpus Striatum; Dopamine; Dopamine Agonists; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Humans; Kynurenic Acid; N-Methylaspartate; Nerve Degeneration; Neurotoxins; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate

2007
Quinolinic acid-induced seizures stimulate glutamate uptake into synaptic vesicles from rat brain: effects prevented by guanine-based purines.
    Neurochemical research, 2008, Volume: 33, Issue:1

    Topics: Animals; Brain; Glutamic Acid; Guanine; Male; Quinolinic Acid; Rats; Rats, Wistar; Seizures; Synaptic Vesicles

2008
Behavioural and neurochemical characterization of the adenosine A2A receptor antagonist ST1535.
    European journal of pharmacology, 2008, Jan-28, Volume: 579, Issue:1-3

    Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Corpus Striatum; Dose-Response Relationship, Drug; Glutamic Acid; Male; Microdialysis; Motor Activity; Neuroprotective Agents; Quinolinic Acid; Rats; Rats, Wistar; Triazoles

2008
An organotellurium compound with antioxidant activity against excitotoxic agents without neurotoxic effects in brain of rats.
    Brain research bulletin, 2008, May-15, Volume: 76, Issue:1-2

    Topics: Animals; Antioxidants; Brain; Glutamic Acid; Lipid Peroxidation; Mitochondria; Neurotoxins; Nitric Oxide Donors; Nitroprusside; Organophosphonates; Quinolinic Acid; Rats; Rats, Wistar; Synaptosomes; Tellurium; Thiobarbituric Acid Reactive Substances; Vinyl Compounds

2008
Crystal structure of bovine 3-hydroxyanthranilate 3,4-dioxygenase.
    Biopolymers, 2009, Volume: 91, Issue:12

    Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; 3-Hydroxyanthranilic Acid; Amino Acid Sequence; Animals; Binding Sites; Catalytic Domain; Cattle; Crystallization; Crystallography, X-Ray; Glutamic Acid; Histidine; Iron; Kidney; Models, Chemical; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Quinolinic Acid; Sequence Homology, Amino Acid

2009
Ciliary neurotrophic factor protects striatal neurons against excitotoxicity by enhancing glial glutamate uptake.
    PloS one, 2010, Jan-01, Volume: 5, Issue:1

    Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Ciliary Neurotrophic Factor; Corpus Striatum; Evoked Potentials; Glutamic Acid; In Vitro Techniques; Neurons; Quinolinic Acid; Rats

2010
Characterisation of the expression of NMDA receptors in human astrocytes.
    PloS one, 2010, Nov-30, Volume: 5, Issue:11

    Topics: Adult; Astrocytes; Brain; Calcium; Cell Membrane; Cell Survival; Cells, Cultured; Dizocilpine Maleate; Gene Expression Profiling; Glutamic Acid; Humans; Immunohistochemistry; L-Lactate Dehydrogenase; Memantine; Microscopy, Confocal; Protein Subunits; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction

2010
Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission?
    Journal of neuroinflammation, 2011, Aug-10, Volume: 8

    Topics: Adult; Aged; Depressive Disorder, Major; Female; Glutamic Acid; Gyrus Cinguli; Humans; Male; Microglia; Middle Aged; Quinolinic Acid; Serotonin; Synaptic Transmission; Tryptophan

2011
Cooperation of non-effective concentration of glutamatergic system modulators and antioxidant against oxidative stress induced by quinolinic acid.
    Neurochemical research, 2012, Volume: 37, Issue:9

    Topics: Animals; Antioxidants; Benzene Derivatives; Brain Chemistry; Cell Survival; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Guanosine; Indicators and Reagents; Lipid Peroxidation; Male; Nerve Tissue Proteins; Organoselenium Compounds; Oxidants; Oxidative Stress; Quinolinic Acid; Rats; Reactive Oxygen Species; Thiobarbituric Acid Reactive Substances

2012
Cathepsin L plays a role in quinolinic acid-induced NF-Κb activation and excitotoxicity in rat striatal neurons.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: Animals; Apoptosis; Blotting, Western; Cathepsin L; Cell Proliferation; Cells, Cultured; Corpus Striatum; Cysteine Proteinase Inhibitors; Dipeptides; Fluorescent Antibody Technique; Glutamic Acid; Ketones; Male; Neurons; NF-kappa B; Proteolysis; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tumor Suppressor Protein p53

2013
[Hippocampus quinolinic acid modulates glutamate and NMDAR/mGluR1 in chronic unpredictable mild stress-induced depression].
    Sheng li xue bao : [Acta physiologica Sinica], 2013, Dec-25, Volume: 65, Issue:6

    Topics: Animals; Behavior, Animal; Depression; Dizocilpine Maleate; Glutamic Acid; Hippocampus; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Stress, Psychological

2013
Aloysia gratissima prevents cellular damage induced by glutamatergic excitotoxicity.
    The Journal of pharmacy and pharmacology, 2014, Volume: 66, Issue:9

    Topics: Animals; Biological Transport; Cell Death; Cell Survival; Coumaric Acids; Excitatory Amino Acid Agonists; Excitatory Amino Acids; Glutamic Acid; Hippocampus; Male; Mice, Inbred Strains; Neuroprotective Agents; Neurotoxicity Syndromes; Phosphatidylinositol 3-Kinase; Phytotherapy; Plant Extracts; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Seizures; Verbenaceae

2014
Reduced microglial immunoreactivity for endogenous NMDA receptor agonist quinolinic acid in the hippocampus of schizophrenia patients.
    Brain, behavior, and immunity, 2014, Volume: 41

    Topics: Adult; CA1 Region, Hippocampal; Cell Count; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Hippocampus; HLA-DR Antigens; Humans; Male; Microglia; Middle Aged; Neuroimmunomodulation; Organ Specificity; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Synaptic Transmission

2014
N-methyl-D-aspartate preconditioning prevents quinolinic acid-induced deregulation of glutamate and calcium homeostasis in mice hippocampus.
    Neurotoxicity research, 2015, Volume: 27, Issue:2

    Topics: Animals; Calcium; D-Aspartic Acid; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Homeostasis; Male; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Quinolinic Acid; Seizures

2015
Neuroprotective Activity of Curcumin in Combination with Piperine against Quinolinic Acid Induced Neurodegeneration in Rats.
    Pharmacology, 2016, Volume: 97, Issue:3-4

    Topics: Adenosine; Alkaloids; Animals; Antioxidants; Benzodioxoles; Brain; Catecholamines; Curcumin; Cytokines; Drug Therapy, Combination; gamma-Aminobutyric Acid; Glutamic Acid; Glutathione; Hand Strength; Huntington Disease; Lipid Peroxidation; Locomotion; Neuroprotective Agents; Nitrites; Piperidines; Polyunsaturated Alkamides; Quinolinic Acid; Rats, Wistar

2016
Atorvastatin Prevents Glutamate Uptake Reduction Induced by Quinolinic Acid Via MAPKs Signaling.
    Neurochemical research, 2016, Volume: 41, Issue:8

    Topics: Amino Acid Transport System X-AG; Animals; Atorvastatin; Glutamic Acid; Male; MAP Kinase Signaling System; Mice; Quinolinic Acid

2016
Neuroprotective effects of intrastriatal injection of rapamycin in a mouse model of excitotoxicity induced by quinolinic acid.
    Journal of neuroinflammation, 2017, 01-31, Volume: 14, Issue:1

    Topics: Animals; Body Weight; Corpus Striatum; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Movement Disorders; Nerve Degeneration; Neuroglia; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Postural Balance; Potassium Chloride; Quinolinic Acid; Sirolimus; Synaptosomes

2017
Sertraline and venlafaxine improves motor performance and neurobehavioral deficit in quinolinic acid induced Huntington's like symptoms in rats: Possible neurotransmitters modulation.
    Pharmacological reports : PR, 2017, Volume: 69, Issue:2

    Topics: Animals; Corpus Striatum; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Huntington Disease; Interleukin-1beta; Interleukin-6; Lipid Peroxidation; Male; Motor Activity; Neuroprotective Agents; Neurotransmitter Agents; Oxidative Stress; Quinolinic Acid; Rats; Rats, Wistar; Rotarod Performance Test; Sertraline; Tumor Necrosis Factor-alpha; Venlafaxine Hydrochloride

2017
Melanocortin receptor subtypes are expressed on cells in the oligodendroglial lineage and signal ACTH protection.
    Journal of neuroscience research, 2018, Volume: 96, Issue:3

    Topics: Adrenocorticotropic Hormone; Animals; Animals, Newborn; Apoptosis; Cell Death; Cells, Cultured; Glutamic Acid; Hydrogen Peroxide; Immunohistochemistry; Oligodendroglia; Primary Cell Culture; Prosencephalon; Quinolinic Acid; Rats, Sprague-Dawley; Receptors, Melanocortin; Staurosporine

2018
Quinolinic acid and glutamatergic neurodegeneration in Caenorhabditis elegans.
    Neurotoxicology, 2018, Volume: 67

    Topics: Animals; Animals, Genetically Modified; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Dose-Response Relationship, Drug; Glutamic Acid; Locomotion; Neurodegenerative Diseases; Quinolinic Acid; Reactive Oxygen Species; Touch

2018
Chronic Mild Stress Alters Kynurenine Pathways Changing the Glutamate Neurotransmission in Frontal Cortex of Rats.
    Molecular neurobiology, 2019, Volume: 56, Issue:1

    Topics: Animals; Antidepressive Agents; Chronic Disease; Cytokines; Frontal Lobe; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammation Mediators; Kynurenic Acid; Kynurenine; Male; Metabolic Networks and Pathways; Quinolinic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Stress, Psychological; Synaptic Transmission; Tryptophan

2019
Safranal Attenuates Excitotoxin-Induced Oxidative OLN-93 Cells Injury.
    Drug research, 2019, Volume: 69, Issue:6

    Topics: Animals; Antioxidants; Cell Survival; Cyclohexenes; Glutamic Acid; Multiple Sclerosis; Neurotoxins; Oligodendroglia; Oxidative Stress; Quinolinic Acid; Rats; Reactive Oxygen Species; Terpenes

2019
Protein kinase C is involved in the neuroprotective effect of berberine against intrastriatal injection of quinolinic acid-induced biochemical alteration in mice.
    Journal of cellular and molecular medicine, 2019, Volume: 23, Issue:9

    Topics: Animals; Berberine; Cognitive Dysfunction; Disease Models, Animal; Glutamic Acid; Glycogen Synthase Kinase 3 beta; Male; Mice; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Protein Kinase C; Quinolinic Acid; Signal Transduction

2019
Caenorhabditis elegans as a model for studies on quinolinic acid-induced NMDAR-dependent glutamatergic disorders.
    Brain research bulletin, 2021, Volume: 175

    Topics: 1-Octanol; Adenosine Triphosphate; Amino Acid Metabolism, Inborn Errors; Animals; Animals, Genetically Modified; Caenorhabditis elegans; Citrate (si)-Synthase; Disease Models, Animal; Glutamic Acid; Humans; Kynurenine; Motor Activity; Neurodegenerative Diseases; Quinolinic Acid; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synaptic Transmission

2021
    Nutrients, 2022, Apr-13, Volume: 14, Issue:8

    Topics: Animals; Autistic Disorder; Bifidobacterium longum; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Kynurenine; Neuroinflammatory Diseases; Neurotransmitter Agents; Quinolinic Acid; Rats

2022
Urine metabolomic characteristics of female patients with occupational chronic cadmium poisoning after 15 years of treatment.
    Biomedical chromatography : BMC, 2023, Volume: 37, Issue:1

    Topics: Biomarkers; Cadmium Poisoning; Creatine; Female; Glutamic Acid; Humans; Metabolomics; Niacin; Quinolinic Acid

2023