glutamic acid has been researched along with phencyclidine in 138 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (13.77) | 18.7374 |
| 1990's | 56 (40.58) | 18.2507 |
| 2000's | 36 (26.09) | 29.6817 |
| 2010's | 26 (18.84) | 24.3611 |
| 2020's | 1 (0.72) | 2.80 |
| Authors | Studies |
|---|---|
| Anis, NA; Bukownik, R; Eldefrawi, AT; Eldefrawi, ME; Goodnow, RA; Nakanishi, K; Usherwood, PN | 1 |
| Cler, JA; Garland, DJ; Hood, WF; Iyengar, S; Mick, SJ; Monahan, JB; Rao, TS; Sun, ET; Vazquez, ML | 1 |
| Fauq, AH; Kozikowski, AP; Rajdev, S; Reynolds, IJ; Rothermund, K | 1 |
| Holopainen, I; Janáky, R; Oja, SS; Saransaari, P; Varga, V | 1 |
| Bonhaus, DW; McNamara, JO | 1 |
| Bowen, DM; Cross, AJ; Green, AR; Robinson, TN; Steele, JE | 1 |
| Johnson, KM; Sacaan, AI | 2 |
| Angst, C; Brundish, DE; Fagg, G; Hurt, SD; Pozza, M; Sills, MA; Williams, M; Wilusz, EJ | 1 |
| Buso, M; Facci, L; Guidolin, D; Leon, A; Milani, D; Pozzan, T; Skaper, SD | 1 |
| Carter, AJ; Müller, RE | 1 |
| Hatta, K; Hori, T; Moroji, T; Yamamoto, T | 2 |
| Bowen, WD; Reid, AA; Rothman, RB; Setterlund, C | 1 |
| Dragunow, M; Faull, RL; Jansen, KL; Leslie, RA | 1 |
| Ogita, K; Yoneda, Y | 1 |
| Jeng, YJ; Johnson, KM | 1 |
| Bonhaus, DW; McNamara, JO; Yeh, GC | 1 |
| Alesiani, M; Carlà, V; Cherici, G; Galli, A; Mori, F; Moroni, F; Pecorari, R; Pellicciari, R | 1 |
| Fujiwara, M; Fukunaga, R; Kameyama, M; Ninomiya, H; Shimohama, S; Taniguchi, T | 1 |
| Compton, RP; Hood, WF; Monahan, JB | 1 |
| Bommarito, M; Johnston, MV; McDonald, JW; Silverstein, FS | 1 |
| Close, SP; Elliott, PJ; Hayes, AG; Marriott, AS; Walsh, DM | 1 |
| Feuerstein, G; Lysko, PG | 1 |
| Foucaud, B; Gombos, G | 1 |
| Aanonsen, LM; Wilcox, GL | 1 |
| Braunwalder, AF; Jarvis, MF; Loo, PA; Murphy, DE; Sills, MA; Williams, M | 1 |
| Boggan, WO; Ondo, JG | 1 |
| Morozova, KI | 1 |
| Loo, PS; Sills, MA | 1 |
| Johnson, KM; Jones, SM | 1 |
| Nishikawa, T; Takahashi, K; Tanii, Y; Yoshida, Y | 1 |
| Kozikowski, AP; Maloneyhuss, K; Tueckmantel, W | 1 |
| Albuquerque, EX; Idriss, M | 1 |
| Braunwalder, A; Lehmann, J; Loo, P; Williams, M | 1 |
| Johnson, KM; Snell, LD | 1 |
| Kameyama, M; Nabatame, H; Ohno, Y; Sasa, M; Takaori, S | 1 |
| Javitt, DC; Jotkowitz, A; Sircar, R; Zukin, SR | 1 |
| Braunwalder, AF; Lehmann, J; Loo, PS; Sills, MA; Williams, M | 1 |
| Ambar, I; Kloog, Y; Sokolovsky, M | 1 |
| Astier, H; Tapia-Arancibia, L | 1 |
| Alho, H; Bertolino, M; Costa, E; Favaron, M; Ferret, B; Guidotti, A; Manev, H | 1 |
| Chicheportiche, R; Drian, MJ; Kamenka, JM; Privat, A; Rondouin, G | 1 |
| Guyenet, PG; Raja, SN | 1 |
| Ahmad, M; Babcock, KK; Chen, X; Johnson, PS; Kumar, KN; Michaelis, EK | 1 |
| Lillrank, SM; O'Connor, WT; Saransaari, P; Ungerstedt, U | 1 |
| Baba, A; Goji, K; Kawai, N; Klenerová, V; Moroji, T; Sagi, N; Takamori, E; Yamamoto, H; Yamamoto, T | 1 |
| Lillrank, SM; O'Connor, WT; Oja, SS; Ungerstedt, U | 1 |
| Bockaert, J; Didier, M; Gonalons, N; Héaulme, M; Pin, JP; Soubrié, P | 1 |
| Henley, JM; Hunt, SP; Jenkins, R | 1 |
| Ali, SF; Bowyer, JF; Holson, RR; Newport, GD; Slikker, W | 1 |
| Mennini, T; Miari, A; Presti, ML; Rizzi, M; Samanin, R; Vezzani, A | 1 |
| Arckens, L; Orban, GA; Rosier, AM; Vandesande, F | 1 |
| Ogita, K; Suzuki, T; Yoneda, Y | 1 |
| Hashimoto, K; Hirano, M; Hondo, H; Kuroki, T; Matsumoto, T; Uchimura, H; Yonezawa, Y | 1 |
| Kovács, KJ; Larson, AA | 1 |
| Barson, AJ; D'Souza, SW; McConnell, SE; Slater, P | 1 |
| Lillrank, SM; Oja, SS; Saransaari, P | 1 |
| Halberstadt, AL | 1 |
| Chen, X; Hurlbert, M; Joseph, DB; Kumar, KN; Michaelis, EK; Michaelis, ML | 1 |
| Gao, XM; Tamminga, CA | 1 |
| Carter, C; Fage, D; Klarica, M | 1 |
| Baba, A; Goji, K; Kawai, N; Moroji, T; Yamamoto, H; Yamamoto, T; Yang, X | 1 |
| Larsen, H; Monaghan, DT | 1 |
| Jiwa, D; Löscher, W; Nobrega, JN; Raymond, R; Richter, A | 1 |
| Frusciante, M; Javitt, DC | 1 |
| Frandsen, A; Hansen, HS; Lauritzen, L; Schousboe, A; Strand, AM; Vinggaard, AM | 1 |
| Goff, DC; Wine, L | 1 |
| Mateu, G; Privat, A; Thibault, J; Vignon, J | 2 |
| Adams, B; Moghaddam, B | 1 |
| Adams, BW; Moghaddam, B | 2 |
| Wickelgren, I | 1 |
| Kakigi, T; Maeda, K; Yamamoto, Y | 1 |
| Chaudieu, I; Privat, A | 1 |
| Caron, MG; Gainetdinov, RR; Koller, BH; Mohn, AR | 1 |
| Barber, DJ; Cooper, AJ; Griffiths, MR; Mitchell, IJ | 1 |
| Sircar, R | 1 |
| Sabel, BA; Schroeder, H; Schroeder, U; Schwegler, H | 1 |
| Furukawa, H; Ichihara, K; Kamei, H; Mamiya, T; Nabeshima, T; Nagai, T; Noda, A; Noda, Y; Sugiura, S | 1 |
| Coyle, JT; Tsai, G | 1 |
| Abekawa, T; Honda, M; Inoue, T; Ito, K; Koyama, T | 1 |
| Hirbec, H; Kamenka, JM; Mausset, AL; Privat, A; Vignon, J | 1 |
| Cochran, SM; Fujimura, M; Morris, BJ; Pratt, JA | 1 |
| Bellack, AS; Billingslea, EN; Deutsch, SI; Mastropaolo, J; Rosse, RB | 1 |
| Moghaddam, B; Takahata, R | 1 |
| Holland, T; Killian, C; Lajtha, A; Lipovac, MN; Poleksic, A | 1 |
| Abekawa, T; Honda, M; Ito, K; Koyama, T | 1 |
| Coyle, JT; Javitt, DC | 1 |
| Hu, JY; Takigawa, M; Wang, HD | 1 |
| Castner, SA; Goldman-Rakic, PS; Williams, GV | 1 |
| Engberg, G; Erhardt, S; Schwieler, L | 1 |
| Javitt, DC | 4 |
| Goodman, CB; Harris, C; Lee, E; Oriaku, ET; Soliman, KF; Thomas, M; Williams, Z | 1 |
| Abekawa, T; Ito, K; Koyama, T | 2 |
| Mouri, A; Murai, R; Nabeshima, T; Noda, Y | 1 |
| Balaraman, Y; Edenberg, HJ; Faraone, SV; Geyer, MA; Jerome, RE; Kuczenski, R; Le-Niculescu, H; Niculescu, AB; Nurnberger, JI; Patel, S; Sidhu, K; Tan, J; Tsuang, MT | 1 |
| Ballmaier, M; Bortolato, M; Gessa, G; Heinz, A; Rizzetti, C; Spano, P; Zoli, M | 1 |
| Harte, MK; Reynolds, GP | 1 |
| Furukawa, H; Kamei, H; Matsuba, K; Matsui, K; Mouri, A; Murai, R; Nabeshima, T; Nitta, A; Noda, Y | 1 |
| Enomoto, T; Nabeshima, T; Noda, Y | 1 |
| Baker, DA; Haroutunian, V; Kristiansen, LV; Madayag, A; Meador-Woodruff, JH; Raju, I | 1 |
| Hoshino, KY; Jodo, E; Katayama, T; Kayama, Y; Suzuki, Y; Takeuchi, S | 1 |
| Bragina, L; Candiracci, C; Conti, F; Cozzi, A; Fattorini, G; Matute, C; Melone, M; Pellegrini Giampietro, DE; Pérez-Samartín, A; Torres-Ramos, M | 1 |
| Ballantyne, P; Huang, XF; Newell, K; Nguyen, V; Zavitsanou, K | 1 |
| Bragina, L; Candiracci, C; Conti, F; Cozzi, A; Fattorini, G; Melone, M; Pellegrini-Giampietro, DE | 1 |
| Deelchand, DK; Eberly, LE; Henry, PG; Iltis, I; Koski, DM; Lim, KO; Nelson, CD; Ugurbil, K; Valette, J | 1 |
| Biedermann, F; Fleischhacker, WW | 1 |
| Boules, M; Li, Z; Peris, J; Richelson, E; Williams, K | 1 |
| Blau, C; Fagan, AJ; Harte, M; Harvey, RP; Kerskens, C; Lai, D; O'Leary, C; O'Sullivan, GJ; O'Tuathaigh, CM; Reynolds, GP; Tighe, O; Waddington, JL | 1 |
| Boules, M; Gordillo, A; Li, S; Li, Z; Richelson, E; Williams, K | 1 |
| Fejgin, K; Klamer, D; Pålsson, E; Svensson, L | 1 |
| Amitai, N; Behrens, MM; Kuczenski, R; Markou, A | 1 |
| Hiramatsu, M; Lu, L; Lu, P; Mamiya, T; Mouri, A; Nabeshima, T; Toriumi, K; Zou, LB | 1 |
| Nabeshima, T | 1 |
| Nishikawa, T | 1 |
| Dawson, N; Higham, DJ; Macintyre, L; Morris, BJ; Pratt, JA; Watson, DG; Xiao, X | 1 |
| Hiemstra, S; Tang, H; Thompson, JE | 1 |
| Adell, A; Jiménez-Sánchez, L; López-Gil, X; Romón, T | 1 |
| Aoyama, Y; Ikawa, N; Kim, HC; Lu, L; Mamiya, T; Mouri, A; Nabeshima, T; Nagai, T; Narusawa, S; Toriumi, K | 1 |
| Bzdega, T; Moffett, JR; Neale, JH; Olszewski, RT; Zuo, D | 1 |
| Krystal, JH; Moghaddam, B | 1 |
| Bebensee, A; Papaleo, F; Scheggia, D; Weinberger, DR | 1 |
| Borisova, T; Borysov, A; Kasatkina, L; Krisanova, N; Nazarova, A; Sivko, R; Slenzka, K | 1 |
| Hazama, A; Jodo, E; Katsuda, S; Kobayashi, D; Kodaira, M; Maejima, Y; Otgon-Uul, Z; Sakuma, K; Santoso, P; Shimomura, K; Takigawa, M; Uramura, K; Yada, T; Yang, Y | 1 |
| Caron, MG; Chen, M; Dulman, RS; Jin, J; Park, SM; Rodriguiz, RM; Schmerberg, CM; Wetsel, WC | 1 |
| Engel, M; Frank, E; Huang, XF; Jenner, A; Karl, T; Snikeris, P | 1 |
| Alexander, SP; Fone, KC; Gaskin, PL; Toledo-Rodriguez, M | 1 |
| Gil-Ad, I; Krivoy, A; Taler, M; Tarasenko, I; Weizman, A | 1 |
| Adham, N; Gyertyán, I; Ichinose, F; Kehr, J; Kiss, B; Yoshitake, S; Yoshitake, T | 1 |
| Bertron, JL; Lindsley, CW; Seto, M | 1 |
| He, W; Huang, M; Kwon, S; Meltzer, HY; Rajagopal, L | 1 |
| Brown, AM; Dawe-Lane, E; Evans, C; Fowler, M; King, MV; Newton-Mann, E; Shortall, SE | 1 |
12 review(s) available for glutamic acid and phencyclidine
| Article | Year |
|---|---|
The phencyclidine-glutamate model of schizophrenia.
Topics: Dopamine; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Phencyclidine; Schizophrenia | 1995 |
Glutamate in schizophrenia: clinical and research implications.
Topics: Aging; Citric Acid Cycle; Dopamine; Glutamic Acid; Humans; Phencyclidine; Receptors, Amino Acid; Receptors, Glutamate; Schizophrenia | 1997 |
Glutamatergic mechanisms in schizophrenia.
Topics: Animals; Dopamine; Glutamic Acid; Humans; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2002 |
Animal models of working memory: insights for targeting cognitive dysfunction in schizophrenia.
Topics: Amphetamine; Animals; Cognition Disorders; Dopamine; Glutamic Acid; Humans; Memory, Short-Term; Models, Animal; Phencyclidine; Prefrontal Cortex; Schizophrenia | 2004 |
Glutamate as a therapeutic target in psychiatric disorders.
Topics: Animals; Disease Models, Animal; Drug Design; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Mental Disorders; Phencyclidine; Receptors, Glutamate; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2004 |
Animal model of schizophrenia: dysfunction of NMDA receptor-signaling in mice following withdrawal from repeated administration of phencyclidine.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cognition; Disease Models, Animal; Glutamic Acid; Mice; Motor Activity; Phencyclidine; Prefrontal Cortex; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Schizophrenic Psychology; Signal Transduction | 2006 |
Glutamate and schizophrenia: phencyclidine, N-methyl-D-aspartate receptors, and dopamine-glutamate interactions.
Topics: Animals; Antipsychotic Agents; Brain; Dopamine; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Phencyclidine; Psychoses, Substance-Induced; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2007 |
Phencyclidine and genetic animal models of schizophrenia developed in relation to the glutamate hypothesis.
Topics: Animals; Behavior, Animal; Calcineurin; Cognition; Disease Models, Animal; Gait; Glutamic Acid; Humans; Inhibition, Psychological; Mice; Mice, Knockout; Motor Activity; Nerve Tissue Proteins; Neuregulin-1; Phencyclidine; Receptors, Lysophosphatidic Acid; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Schizophrenic Psychology; Social Behavior | 2007 |
Antipsychotics in the early stage of development.
Topics: Antipsychotic Agents; Dopamine; Glutamic Acid; Humans; Ketamine; Phencyclidine; Receptors, Cholinergic; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Receptors, Serotonin; Schizophrenia; Serotonin; Severity of Illness Index; Synaptic Transmission | 2009 |
Glutamatergic theories of schizophrenia.
Topics: Animals; Brain; Dopamine; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Ketamine; Nerve Net; Phencyclidine; Prefrontal Cortex; Psychological Theory; Receptors, Dopamine D2; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Schizophrenic Psychology; Synaptic Transmission | 2010 |
Capturing the angel in "angel dust": twenty years of translational neuroscience studies of NMDA receptor antagonists in animals and humans.
Topics: Allosteric Regulation; Animals; Antipsychotic Agents; Brief Psychiatric Rating Scale; Cerebral Cortex; Disease Models, Animal; Dopamine; Emotions; Glutamic Acid; Humans; Ketamine; Neurosciences; Phencyclidine; Psychoses, Substance-Induced; Receptor, Metabotropic Glutamate 5; Receptors, Dopamine D2; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Synapses; Translational Research, Biomedical | 2012 |
DARK Classics in Chemical Neuroscience: Phencyclidine (PCP).
Topics: Glutamic Acid; Hallucinogens; History, 20th Century; History, 21st Century; Humans; Phencyclidine; Psychoses, Substance-Induced; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2018 |
126 other study(ies) available for glutamic acid and phencyclidine
| Article | Year |
|---|---|
Synthesis and binding of [125I2]philanthotoxin-343, [125I2]philanthotoxin-343-lysine, and [125I2]philanthotoxin-343-arginine to rat brain membranes.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Iodine Radioisotopes; Kinetics; Male; Neurotoxins; Polyamines; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Spermine; Synaptic Membranes; Wasp Venoms | 1991 |
Characterization of 3-carboxy-5-phosphono-1,2,3,4-tetrahydroisoquinoline (SC-48981), a potent competitive N-methy-D-aspartate (NMDA) receptor antagonist, in vitro and in vivo.
Topics: Animals; Binding, Competitive; Cerebellum; Cyclic GMP; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Isoquinolines; Male; Mice; N-Methylaspartate; Organophosphorus Compounds; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Tetrahydroisoquinolines | 1992 |
[125I]thienylphencyclidine, a novel ligand for the NMDA receptor.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Glutamates; Glutamic Acid; Glycine; Iodine Radioisotopes; Kinetics; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate | 1992 |
Effect of magnesium on calcium influx activated by glutamate and its agonists in cultured cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Calcium Radioisotopes; Cells, Cultured; Cerebellum; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Nifedipine; Phencyclidine; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Glutamate; Verapamil | 1992 |
Uncompetitive antagonist binding: a biochemical index of activation of the NMDA receptor-coupled ion channel.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Culture Techniques; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Ion Channels; Kainic Acid; N-Methylaspartate; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1992 |
A comparison of [3H]MK-801 and N-[1-(2-thienyl)cyclohexyl]-3,4-[3H]piperidine binding to the N-methyl-D-aspartate receptor complex in human brain.
Topics: Aged; Brain; Corpus Striatum; Dizocilpine Maleate; Female; Glutamates; Glutamic Acid; Glycine; Humans; Male; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Tritium | 1991 |
Regulation of polyamine and magnesium inhibition of the N-methyl-D-aspartate (NMDA) receptor ionophore complex.
Topics: Animals; Biogenic Polyamines; Dizocilpine Maleate; Erythrocyte Membrane; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Magnesium; Phencyclidine; Putrescine; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Structure-Activity Relationship | 1991 |
[3H]CGP 39653: a new N-methyl-D-aspartate antagonist radioligand with low nanomolar affinity in rat brain.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Cerebral Cortex; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Male; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Excitatory amino acid-induced alterations of cytoplasmic free Ca2+ in individual cerebellar granule neurons: role in neurotoxicity.
Topics: Aminoquinolines; Animals; Calcium; Calcium Channels; Cell Survival; Cells, Cultured; Cerebellar Cortex; Cytoplasm; Excitatory Amino Acid Antagonists; G(M1) Ganglioside; Glutamates; Glutamic Acid; Ion Channel Gating; Magnesium; Neurons; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1991 |
Activation of excitatory amino acid receptors cannot alone account for anoxia-induced impairment of protein synthesis in rat hippocampal slices.
Topics: Animals; Aspartic Acid; Carbon Radioisotopes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hippocampus; Hypoxia; Kainic Acid; Lysine; Male; N-Methylaspartate; Nerve Tissue Proteins; Phenazocine; Phencyclidine; Quisqualic Acid; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate | 1991 |
Modulation of Mg(2+)-dependent [3H]TCP binding by L-glutamate, glycine, and guanine nucleotides in rat cerebral cortex.
Topics: Animals; Binding, Competitive; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Guanylyl Imidodiphosphate; Illicit Drugs; Kinetics; Magnesium; Male; Phencyclidine; Potassium; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Synaptic Membranes; Tritium | 1991 |
The competitive NMDA receptor antagonist, CPP, allosterically modulates NMDA receptor associated PCP binding sites in the absence of steric hinderance.
Topics: Animals; Dizocilpine Maleate; Glutamates; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Kinetics; Membranes; Molecular Conformation; Phencyclidine; Piperazines; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1990 |
Autoradiographic visualisation of [3H]DTG binding to sigma receptors, [3H]TCP binding sites, and L-[3H]glutamate binding to NMDA receptors in human cerebellum.
Topics: Autoradiography; Female; Glutamates; Glutamic Acid; Guanidines; Humans; Male; Middle Aged; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Tritium | 1991 |
Inhibitory modulation by sodium ions of the N-methyl-D-aspartate recognition site in brain synaptic membranes.
Topics: Animals; Binding, Competitive; Brain; Detergents; Glutamates; Glutamic Acid; Ions; Kinetics; Male; Octoxynol; Phencyclidine; Polyethylene Glycols; Rats; Receptors, N-Methyl-D-Aspartate; Sodium; Synaptic Membranes | 1991 |
Pharmacological evidence for N-methyl-D-aspartate receptors on nigrostriatal dopaminergic nerve terminals.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Corpus Striatum; Dopamine; Female; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Magnesium; Nerve Endings; Phencyclidine; Piperazines; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Substantia Nigra; Synaptosomes; Tetrodotoxin | 1991 |
Evidence that zinc inhibits N-methyl-D-aspartate receptor-gated ion channel activation by noncompetitive antagonism of glycine binding.
Topics: Animals; Binding Sites; Glutamates; Glutamic Acid; Glycine; Ion Channels; Male; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Zinc | 1990 |
Thiokynurenates: a new group of antagonists of the glycine modulatory site of the NMDA receptor.
Topics: Animals; Binding Sites; Cerebral Cortex; Chlorine; Fluorine; Glutamates; Glutamic Acid; Glycine; Guinea Pigs; Ileum; Ion Channels; Kynurenic Acid; Mice; Muscle Contraction; Myenteric Plexus; Phencyclidine; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship | 1991 |
[3H]N-[1-(2-thienyl)cyclohexyl]-3,4-piperidine ([3H]TCP) binding in human frontal cortex: decreases in Alzheimer-type dementia.
Topics: Alzheimer Disease; Aspartic Acid; Binding Sites; Frontal Lobe; Glutamates; Glutamic Acid; Humans; Membranes; N-Methylaspartate; Phencyclidine; Reference Values | 1990 |
N-methyl-D-aspartate recognition site ligands modulate activity at the coupled glycine recognition site.
Topics: Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Glutamates; Glutamic Acid; Glycine; Ligands; N-Methylaspartate; Phencyclidine; Pipecolic Acids; Piperidines | 1990 |
Effects of hypoxia-ischemia and MK-801 treatment on the binding of a phencyclidine analogue in the developing rat brain.
Topics: Animals; Animals, Newborn; Aspartic Acid; Autoradiography; Binding Sites; Brain; Brain Ischemia; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hypoxia; N-Methylaspartate; Phencyclidine; Rats; Rats, Inbred Strains; Tritium | 1990 |
Neuroleptic-induced catalepsy as a model of Parkinson's disease. II. Effect of glutamate antagonists.
Topics: Animals; Antipsychotic Agents; Catalepsy; Disease Models, Animal; Dizocilpine Maleate; Fluphenazine; Glutamates; Glutamic Acid; Male; Microinjections; Parkinson Disease; Phencyclidine; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Sulpiride | 1990 |
Competitive inhibition of magnesium-induced [3H]N-(1-[thienyl] cyclohexyl)piperidine binding by arcaine: evidence for a shared spermidine-magnesium binding site.
Topics: Animals; Biguanides; Binding Sites; Binding, Competitive; Dose-Response Relationship, Drug; Drug Interactions; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Magnesium; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Strychnine | 1990 |
Excitatory amino acid neurotoxicity at the N-methyl-D-aspartate receptor in cultured neurons: protection by SKF 10,047.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebellum; Dopamine Agents; Glutamates; Glutamic Acid; Neurons; Neurotoxins; Phenazocine; Phencyclidine; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1990 |
Identification and characterization of a high-affinity glutamate-controlled TCP binding site in rat brain postsynaptic densities.
Topics: Animals; Brain; Cell Membrane; Dizocilpine Maleate; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Subcellular Fractions; Synapses; Synaptosomes | 1990 |
Biphasic effects of magnesium on the [3H]N-(1-(2-thienyl)cyclohexyl)-3,4-piperidine binding in the rat cerebral cortex.
Topics: Animals; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; Magnesium; Male; Phencyclidine; Rats; Rats, Inbred Strains; Tritium | 1990 |
Phencyclidine selectively blocks a spinal action of N-methyl-D-aspartate in mice.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Aspartic Acid; Dipeptides; Drug Interactions; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glutamates; Glutamic Acid; Injections, Spinal; Kainic Acid; Male; Mice; N-Methylaspartate; Norepinephrine; Oxadiazoles; Phencyclidine; Quisqualic Acid; Spinal Cord; Substance P; Tetrazoles; Valine | 1986 |
The N-methyl-D-aspartate receptor complex.
Topics: Anesthetics, Dissociative; Animals; Cerebral Cortex; Glutamates; Glutamic Acid; Ion Channels; Magnesium; Models, Biological; Phencyclidine; Piperazines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1988 |
Effect of central administration of phencyclidine on plasma concentrations of luteinizing hormone.
Topics: Animals; Glutamates; Glutamic Acid; Homocysteine; Injections, Intraventricular; Luteinizing Hormone; Male; Orchiectomy; Phencyclidine; Rats; Rats, Inbred Strains | 1989 |
[Urinary excretion of hydroxyproline after exposure to quartz dust and glutamic acid].
Topics: Animals; Circadian Rhythm; Dust; Glutamates; Glutamic Acid; Hydroxyproline; Quartz; Rats; Silicon Dioxide; Silicosis; Time Factors | 1989 |
Tricyclic antidepressants and dextromethorphan bind with higher affinity to the phencyclidine receptor in the absence of magnesium and L-glutamate.
Topics: Animals; Antidepressive Agents, Tricyclic; Dextromethorphan; Glutamates; Glutamic Acid; In Vitro Techniques; Levorphanol; Magnesium; Male; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1989 |
Effects of amygdaloid kindling on NMDA receptor function and regulation.
Topics: Amygdala; Animals; Aspartic Acid; Brain; Glutamates; Glutamic Acid; Glycine; Hippocampus; Kindling, Neurologic; Male; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
Frontal decortication decreases the affinity of N-(1-[2-thienyl]cyclohexyl)[3H]piperidine binding to rat striatum.
Topics: Animals; Cerebral Decortication; Corpus Striatum; Frontal Lobe; Glutamates; Glutamic Acid; Male; Neural Pathways; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1989 |
The discovery of new chemical modulators of the N-methyl-D-aspartate receptor.
Topics: Glutamates; Glutamic Acid; Molecular Conformation; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Structure-Activity Relationship | 1989 |
Phencyclidine (PCP) blocks glutamate-activated postsynaptic currents.
Topics: Animals; Electric Stimulation; Electrophysiology; Evoked Potentials; Glutamates; Glutamic Acid; Grasshoppers; Neuromuscular Junction; Phencyclidine; Receptors, Glutamate; Receptors, Neurotransmitter; Synapses | 1985 |
Radioligand binding to central phencyclidine recognition sites is dependent on excitatory amino acid receptor agonists.
Topics: Animals; Brain; Glutamates; Glutamic Acid; In Vitro Techniques; Phencyclidine; Radioligand Assay; Rats; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, Neurotransmitter; Receptors, Phencyclidine; Synaptic Membranes | 1986 |
Characterization of the inhibition of excitatory amino acid-induced neurotransmitter release in the rat striatum by phencyclidine-like drugs.
Topics: Animals; Aspartic Acid; Corpus Striatum; Glutamates; Glutamic Acid; Homocysteine; In Vitro Techniques; Kainic Acid; Magnesium; Male; N-Methylaspartate; Neurotransmitter Agents; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma | 1986 |
Activation of lateral vestibular nucleus neurons by iontophoretically applied phencyclidine.
Topics: Acetylcholine; Animals; Atropine; Cats; Female; Glutamates; Glutamic Acid; Iontophoresis; Male; Neurons; Phencyclidine; Synapses; Vestibular Nuclei | 1986 |
Non-competitive regulation of phencyclidine/sigma-receptors by the N-methyl-D-aspartate receptor antagonist D-(-)-2-amino-5-phosphonovaleric acid.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Glutamates; Glutamic Acid; Humans; Male; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Phencyclidine; Receptors, sigma; Schizophrenia; Valine | 1987 |
Interaction of L-glutamate and magnesium with phencyclidine recognition sites in rat brain: evidence for multiple affinity states of the phencyclidine/N-methyl-D-aspartate receptor complex.
Topics: Animals; Brain; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Magnesium; Male; Phenazocine; Phencyclidine; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine | 1987 |
Solubilization of rat brain phencyclidine receptors in an active binding form that is sensitive to N-methyl-D-aspartate receptor ligands.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Binding, Competitive; Brain Chemistry; Cell Membrane; Cholic Acid; Cholic Acids; Detergents; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Receptors, Phencyclidine; Solubility; Valine | 1988 |
Glutamate stimulates somatostatin release from diencephalic neurons in primary culture.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Cells, Cultured; Diencephalon; Glutamates; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Neurons; Oxadiazoles; Phencyclidine; Potassium; Quisqualic Acid; Rats; Somatostatin; Tetrodotoxin; Valine; Veratridine | 1988 |
Gangliosides prevent glutamate and kainate neurotoxicity in primary neuronal cultures of neonatal rat cerebellum and cortex.
Topics: Animals; Animals, Newborn; Cells, Cultured; Cerebellum; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; Gangliosides; Glutamates; Glutamic Acid; Kainic Acid; Lethal Dose 50; Neurons; Phencyclidine; Phosphatidylinositols; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter; Signal Transduction | 1988 |
Non-competitive antagonists of N-methyl-D-aspartate receptors protect cortical and hippocampal cell cultures against glutamate neurotoxicity.
Topics: Animals; Cells, Cultured; Cerebral Cortex; Dibenzocycloheptenes; Dizocilpine Maleate; Glutamates; Glutamic Acid; Hippocampus; Neurotoxins; Phencyclidine; Prodrugs; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1988 |
Action of phencyclidine on synaptic transmission in the hippocampus.
Topics: Acetylcholine; Animals; Drug Interactions; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; Iontophoresis; Ketamine; Male; Phencyclidine; Rats; Synaptic Transmission | 1982 |
Cloning of the cDNA for a brain glycine-, glutamate- and thienylcyclohexylpiperidine-binding protein.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Blotting, Northern; Brain; Cloning, Molecular; Cysteine; DNA, Complementary; Gene Library; Glutamic Acid; Glycine; Hippocampus; Illicit Drugs; Kinetics; Membrane Glycoproteins; Molecular Sequence Data; Nerve Tissue Proteins; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Sequence Homology, Amino Acid; Substrate Specificity; Synaptic Membranes | 1995 |
In vivo effects of local and systemic phencyclidine on the extracellular levels of catecholamines and transmitter amino acids in the dorsolateral striatum of anaesthetized rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aspartic Acid; Catecholamines; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Extracellular Matrix; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Neurotransmitter Agents; Phencyclidine; Rats; Rats, Sprague-Dawley | 1994 |
Sigma ligands indirectly modulate the NMDA receptor-ion channel complex on intact neuronal cells via sigma 1 site.
Topics: 2-Amino-5-phosphonovalerate; Animals; Cells, Cultured; Dizocilpine Maleate; Glutamic Acid; Ion Channels; Ligands; Neurons; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, sigma | 1995 |
Systemic phencyclidine administration is associated with increased dopamine, GABA, and 5-HIAA levels in the dorsolateral striatum of conscious rats: an in vivo microdialysis study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Anesthesia; Animals; Aspartic Acid; Consciousness; Corpus Striatum; Dopamine; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Halothane; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Microdialysis; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serotonin | 1994 |
35 mM K(+)-stimulated 45Ca2+ uptake in cerebellar granule cell cultures mainly results from NMDA receptor activation.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Binding, Competitive; Calcium; Cell Differentiation; Cells, Cultured; Cerebellum; Glutamates; Glutamic Acid; Magnesium; Mice; N-Methylaspartate; Nifedipine; Phencyclidine; Potassium; Receptors, N-Methyl-D-Aspartate | 1993 |
Localisation of glutamate receptor binding sites and mRNAs to the dorsal horn of the rat spinal cord.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Glutamates; Glutamic Acid; Ibotenic Acid; In Situ Hybridization; Kainic Acid; Neural Pathways; Phencyclidine; Rats; Receptors, Glutamate; RNA, Messenger; Spinal Cord; Substantia Gelatinosa | 1993 |
Development of dopamine and N-methyl-D-aspartate systems in rat brain: the effect of prenatal phencyclidine exposure.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Animals, Newborn; Corpus Striatum; Dopamine; Female; Frontal Lobe; Glutamates; Glutamic Acid; Hydroxyindoleacetic Acid; Male; Methamphetamine; N-Methylaspartate; Phencyclidine; Pipecolic Acids; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley | 1993 |
Adaptive changes in the NMDA receptor complex in rat hippocampus after chronic treatment with CGP 39551.
Topics: 2-Amino-5-phosphonovalerate; Animals; Autoradiography; Dizocilpine Maleate; Glutamic Acid; Hippocampus; Kynurenic Acid; Male; Norepinephrine; Phencyclidine; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1994 |
Laminar distribution of NMDA receptors in cat and monkey visual cortex visualized by [3H]-MK-801 binding.
Topics: Animals; Autoradiography; Binding, Competitive; Cats; Dizocilpine Maleate; Female; Freeze Drying; Glutamates; Glutamic Acid; Macaca fascicularis; Male; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Vision, Ocular; Visual Cortex | 1993 |
Potentiation by polyamines of an interaction of noncompetitive antagonists at the N-methyl-D-aspartate receptor ionophore complex with phosphatidylserine.
Topics: Animals; Brain; Calmodulin; Dizocilpine Maleate; Glutamates; Glutamic Acid; Glycine; Illicit Drugs; Kinetics; Phencyclidine; Phosphatidylserines; Phospholipids; Polyamines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Synaptic Membranes; Tritium | 1993 |
Effect of phencyclidine on endogenous excitatory amino acid release from the rat anterior cingulate cortex--an in vivo microdialysis study.
Topics: Amino Acids; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Gyrus Cinguli; Male; Microdialysis; Phencyclidine; Potassium; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1993 |
Density of NMDA-coupled and uncoupled 1-[1-(2-[3H]thienyl) cyclohexyl]piperidine recognition sites in the brain and spinal cord: differential effects of NMDA agonists and antagonists.
Topics: Animals; Binding Sites; Brain; Brain Chemistry; Dizocilpine Maleate; Glutamic Acid; Glycine; Haloperidol; Male; Mice; N-Methylaspartate; Phencyclidine; Spinal Cord; Tritium | 1994 |
Postnatal changes in N-methyl-D-aspartate receptor binding and stimulation by glutamate and glycine of [3H]-MK-801 binding in human temporal cortex.
Topics: Adult; Aging; Cerebral Cortex; Dizocilpine Maleate; Female; Glutamates; Glutamic Acid; Glycine; Humans; In Vitro Techniques; Infant; Infant, Newborn; Male; Phencyclidine; Proteins; Receptors, N-Methyl-D-Aspartate; Stimulation, Chemical; Sudden Infant Death; Temporal Lobe | 1993 |
Phencyclidine treatment in mice: effects on phencyclidine binding sites and glutamate uptake in cerebral cortex preparations.
Topics: Animals; Binding Sites; Cerebral Cortex; Glutamates; Glutamic Acid; Glycine; In Vitro Techniques; Male; Mice; Phencyclidine; Stimulation, Chemical; Synaptosomes | 1993 |
Ethanol-induced inhibition of [3H]thienylcyclohexylpiperidine (TCP) binding to NMDA receptors in brain synaptic membranes and to a purified protein complex.
Topics: Animals; Brain Chemistry; Dizocilpine Maleate; Dopamine Antagonists; Ethanol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Haloperidol; Illicit Drugs; Kinetics; Male; Membrane Proteins; N-Methylaspartate; Phencyclidine; Protein Binding; Proteins; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sensitivity and Specificity; Spermidine; Synaptic Membranes; Tritium | 1996 |
MK801 induces late regional increases in NMDA and kainate receptor binding in rat brain.
Topics: Animals; Autoradiography; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Extrapyramidal Tracts; Glutamic Acid; Hippocampus; Kainic Acid; Limbic System; Male; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 1995 |
Pharmacology of N-methyl-D-aspartate-evoked [3H]noradrenaline release in adult rat spinal cord.
Topics: Animals; Aspartic Acid; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Glutamic Acid; N-Methylaspartate; Norepinephrine; Phencyclidine; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Tritium | 1996 |
Non-aminergic effects of amphetamine on the NMDA receptor in primary cultured cortical cells.
Topics: Amphetamines; Animals; Calcium; Cell Membrane; Cells, Cultured; Cerebral Cortex; Glutamic Acid; Haloperidol; Phencyclidine; Protein Kinases; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Tritium | 1996 |
NR1 and NR2 subunit contributions to N-methyl-D-aspartate receptor channel blocker pharmacology.
Topics: Acetamides; Alternative Splicing; Animals; Dextromethorphan; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; Illicit Drugs; Ion Channels; Kinetics; Membrane Potentials; Oocytes; Phencyclidine; Protein Biosynthesis; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Transcription, Genetic; Xenopus laevis | 1997 |
Alterations in N-methyl-D-aspartate receptor binding in dystonic hamster brains.
Topics: Animals; Binding, Competitive; Brain Chemistry; Cricetinae; Dystonia; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Male; Mesocricetus; Mutation; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Tritium | 1997 |
Glycyldodecylamide, a phencyclidine behavioral antagonist, blocks cortical glycine uptake: implications for schizophrenia and substance abuse.
Topics: Animals; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Phencyclidine; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine; Schizophrenia; Substance-Related Disorders; Synaptosomes | 1997 |
Characterization of glutamate-induced formation of N-acylphosphatidylethanolamine and N-acylethanolamine in cultured neocortical neurons.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cell Death; Cells, Cultured; Cerebral Cortex; Embryo, Mammalian; Endocannabinoids; Ethanolamine; Ethanolamines; Glutamic Acid; Ionophores; Mice; Neurons; Phencyclidine; Phosphatidylethanolamines; Polyunsaturated Alkamides; Receptors, N-Methyl-D-Aspartate; Time Factors | 1997 |
Comparison of glutamate and N-methyl-D-aspartate toxicities on rat mesencephalic primary cell cultures.
Topics: Animals; Cells, Cultured; Dopamine; Excitatory Amino Acid Antagonists; Glutamic Acid; Logistic Models; N-Methylaspartate; Neurons; Neuroprotective Agents; Phencyclidine; Rats; Rats, Sprague-Dawley; Substantia Nigra | 1997 |
Corticolimbic dopamine neurotransmission is temporally dissociated from the cognitive and locomotor effects of phencyclidine.
Topics: Animals; Cognition; Dopamine; Glutamic Acid; Hallucinogens; Male; Motor Activity; Nucleus Accumbens; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Stereotyped Behavior; Synaptic Transmission; Time Factors | 1998 |
Reversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats.
Topics: Animals; Bridged Bicyclo Compounds; Disease Models, Animal; Dopamine; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Memory; Motor Activity; Nucleus Accumbens; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Schizophrenia; Stereotyped Behavior; Synaptic Transmission | 1998 |
A new route to treating schizophrenia?
Topics: Animals; Bridged Bicyclo Compounds; Dopamine; Excitatory Amino Acid Agonists; Glutamic Acid; Humans; Maze Learning; Memory; Phencyclidine; Prefrontal Cortex; Rats; Receptors, Metabotropic Glutamate; Schizophrenia | 1998 |
Intra-striatal phencyclidine inhibits N-methyl-D-aspartic acid-stimulated increase in glutamate levels of freely moving rats.
Topics: Animals; Corpus Striatum; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Male; N-Methylaspartate; Phencyclidine; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1999 |
Neuroprotection of cultured foetal rat hippocampal cells against glucose deprivation: are GABAergic neurons less vulnerable or more sensitive to TCP protection?
Topics: Animals; Cell Survival; Cells, Cultured; Drug Resistance; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Hippocampus; L-Lactate Dehydrogenase; Neurons; Neuroprotective Agents; Phencyclidine; Quinoxalines; Rats; Rats, Sprague-Dawley; Time Factors | 1999 |
Mice with reduced NMDA receptor expression display behaviors related to schizophrenia.
Topics: Animals; Antipsychotic Agents; Antisocial Personality Disorder; Behavior, Animal; Calcium Signaling; Clozapine; Disease Models, Animal; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Haloperidol; Male; Mice; Mice, Knockout; Motor Activity; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenic Psychology; Serotonin Antagonists; Sexual Behavior, Animal; Social Behavior; Stereotyped Behavior | 1999 |
Pharmacological mechanisms mediating phencyclidine-induced apoptosis of striatopallidal neurons: the roles of glutamate, dopamine, acetylcholine and corticosteroids.
Topics: Acetylcholine; Adrenal Cortex Hormones; Amphetamine; Animals; Apoptosis; Behavior, Animal; Benzazepines; Biogenic Monoamines; Central Nervous System Stimulants; Cerebral Cortex; Dizocilpine Maleate; Dopamine; Dopamine Agonists; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Globus Pallidus; Glutamic Acid; Hormone Antagonists; Male; Mifepristone; Muscarinic Antagonists; Neostriatum; Neurons; Phencyclidine; Quinpirole; Rats; Rats, Sprague-Dawley; Scopolamine; Stress, Physiological | 2000 |
Developmental maturation of the N-methyl-D-aspartic acid receptor channel complex in postnatal rat brain.
Topics: Age Factors; Animals; Binding, Competitive; Brain; Brain Chemistry; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Male; Phencyclidine; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Spermine; Tritium | 2000 |
Neuroleptics ameliorate phencyclidine-induced impairments of short-term memory.
Topics: Animals; Antipsychotic Agents; Benzazepines; Brain; Excitatory Amino Acid Antagonists; Glutamic Acid; Haloperidol; Interneurons; Male; Memory Disorders; Memory, Short-Term; Phencyclidine; Rats; Risperidone; Schizophrenia; Spiperone | 2000 |
Modulation of glutamate neurotoxicity on mesencephalic dopaminergic neurons in primary cultures by the presence of striatal target cells.
Topics: Animals; Cell Count; Cells, Cultured; Cerebellum; Chlorine; Coculture Techniques; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Combinations; Glial Fibrillary Acidic Protein; Glutamic Acid; Immunohistochemistry; Iodine; Lethal Dose 50; Mesencephalon; Neurons; Neuroprotective Agents; Phencyclidine; Phenols; Phosphopyruvate Hydratase; Rats; Salicylates; Substantia Nigra; Tyrosine 3-Monooxygenase | 2000 |
Phencyclidine impairs latent learning in mice: interaction between glutamatergic systems and sigma(1) receptors.
Topics: Animals; Antipsychotic Agents; Appetitive Behavior; Behavior, Animal; Cycloserine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Exploratory Behavior; Glutamic Acid; Learning; Male; Mice; Mice, Inbred Strains; Narcotic Antagonists; Pentazocine; Phenazocine; Phencyclidine; Piperazines; Reaction Time; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sigma-1 Receptor; Stereoisomerism | 2001 |
Effect of clozapine, haloperidol, or M100907 on phencyclidine-activated glutamate efflux in the prefrontal cortex.
Topics: Animals; Clozapine; Fluorobenzenes; Glutamic Acid; Haloperidol; Male; Microdialysis; Phencyclidine; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Serotonin Antagonists | 2001 |
Effect of MS-153 on the development of behavioral sensitization to stereotypy-inducing effect of phencyclidine.
Topics: Animals; Behavior, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Neuroprotective Agents; Nicotinic Acids; Phencyclidine; Rats; Rats, Sprague-Dawley; Stereotypic Movement Disorder; Synaptic Transmission | 2002 |
Re-evaluation of phencyclidine low-affinity or "non-NMDA" binding sites.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Brain Injuries; Cerebellum; Cyclohexanes; Cyclohexenes; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Neurons; Neuroprotective Agents; Phencyclidine; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Subcellular Fractions; Synapses; Synaptic Transmission; Tritium | 2002 |
Acute and delayed effects of phencyclidine upon mRNA levels of markers of glutamatergic and GABAergic neurotransmitter function in the rat brain.
Topics: Animals; Brain; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Drug Administration Schedule; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Gene Expression; Glutamic Acid; Homer Scaffolding Proteins; HSP70 Heat-Shock Proteins; In Situ Hybridization; Male; Neuropeptides; Parvalbumins; Phencyclidine; Rats; Rats, Long-Evans; RNA, Messenger; Time Factors | 2002 |
Interaction of stress and strain on glutamatergic neurotransmission: relevance to schizophrenia.
Topics: Animals; Behavior, Animal; Dizocilpine Maleate; Electroshock; Excitatory Amino Acid Antagonists; Glutamic Acid; Mice; Mice, Inbred BALB C; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Species Specificity; Stress, Psychological; Synaptic Transmission | 2003 |
Activation of glutamate neurotransmission in the prefrontal cortex sustains the motoric and dopaminergic effects of phencyclidine.
Topics: Animals; Dopamine; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Motor Activity; Motor Neurons; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Stereotyped Behavior; Synaptic Transmission | 2003 |
The possible role of glutamate uptake in metaphit-induced seizures.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Brain; Caudate Nucleus; Dextrans; Female; Glutamic Acid; Guinea Pigs; Hippocampus; Kinetics; Male; Parietal Lobe; Phencyclidine; Seizures | 2003 |
Effects of NRA0045, a novel potent antagonist at dopamine D4, 5-HT2A, and alpha1 adrenaline receptors, and NRA0160, a selective D4 receptor antagonist, on phencyclidine-induced behavior and glutamate release in rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Chromatography, High Pressure Liquid; Clozapine; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Glutamic Acid; Haloperidol; Male; Microdialysis; Motor Activity; Phencyclidine; Piperidines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D4; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Stereotyped Behavior; Thiazoles; Time Factors | 2003 |
Decoding schizophrenia.
Topics: Antipsychotic Agents; Brain; Clozapine; Dopamine; Glutamic Acid; Humans; Neurotransmitter Agents; Perception; Phencyclidine; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Signal Transduction | 2004 |
The blockade by phencyclidine of glutamate-induced intracellular calcium increase in cultured neocortical neurons.
Topics: Animals; Calcium; Cells, Cultured; Chelating Agents; Diagnostic Imaging; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorescein; Glutamic Acid; Intracellular Space; Microscopy, Confocal; N-Methylaspartate; Neocortex; Neurons; Phencyclidine; Rats; Rats, Wistar | 2004 |
Kynurenic acid and schizophrenia.
Topics: Animals; Antipsychotic Agents; Dopamine; Glutamic Acid; Humans; Kynurenic Acid; Male; Models, Neurological; Phencyclidine; Psychoses, Substance-Induced; Rats; Rats, Sprague-Dawley; Schizophrenia; Ventral Tegmental Area | 2003 |
Effects of NMDA receptor inhibition by phencyclidine on the neuronal differentiation of PC12 cells.
Topics: Analysis of Variance; Animals; Biogenic Amines; Blotting, Western; Cell Differentiation; Cell Survival; Chromatography, High Pressure Liquid; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Glutamic Acid; N-Methylaspartate; Nerve Growth Factor; Neurites; Neurons; PC12 Cells; Phencyclidine; Protein Binding; Rats; Receptors, N-Methyl-D-Aspartate; Tritium | 2006 |
Role of the simultaneous enhancement of NMDA and dopamine D1 receptor-mediated neurotransmission in the effects of clozapine on phencyclidine-induced acute increases in glutamate levels in the rat medial prefrontal cortex.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Dose-Response Relationship, Drug; Drug Resistance; Glutamic Acid; Haloperidol; Humans; Male; Microdialysis; Motor Activity; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2006 |
Towards understanding the schizophrenia code: an expanded convergent functional genomics approach.
Topics: Animals; Behavior, Animal; Biomarkers; Clozapine; gamma-Aminobutyric Acid; Gene Expression Regulation; Genetic Linkage; Genomics; Glutamic Acid; Humans; Male; Mice; Mice, Inbred C57BL; Myelin Sheath; Neurotransmitter Agents; Phencyclidine; Reproducibility of Results; Schizophrenia | 2007 |
Cannabinoid receptor antagonists counteract sensorimotor gating deficits in the phencyclidine model of psychosis.
Topics: Animals; Brain; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Phencyclidine; Piperidines; Psychoses, Substance-Induced; Pyrazoles; Rats; Receptors, Cannabinoid; Reflex, Startle; Rimonabant; Schizophrenia; Sensation Disorders; Synaptic Transmission | 2007 |
The neuronal pathology of schizophrenia: molecules and mechanisms.
Topics: Animals; Aspartic Acid; Brain; Corpus Striatum; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Humans; Neurons; Phencyclidine; Schizophrenia | 2007 |
Hypofunctional glutamatergic neurotransmission in the prefrontal cortex is involved in the emotional deficit induced by repeated treatment with phencyclidine in mice: implications for abnormalities of glutamate release and NMDA-CaMKII signaling.
Topics: Analysis of Variance; Animals; Behavior, Animal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Glutamic Acid; Immobility Response, Tonic; In Vitro Techniques; Male; Mice; Phencyclidine; Potassium; Prefrontal Cortex; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2007 |
Different effects of a single and repeated administration of clozapine on phencyclidine-induced hyperlocomotion and glutamate releases in the rat medial prefrontal cortex at short- and long-term withdrawal from this antipsychotic.
Topics: Amphetamines; Animals; Antipsychotic Agents; Clozapine; Glutamic Acid; Male; Motor Activity; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2007 |
Contribution of cystine-glutamate antiporters to the psychotomimetic effects of phencyclidine.
Topics: Acetylcysteine; Aged; Aged, 80 and over; Amino Acids; Analysis of Variance; Animals; Behavior, Animal; Cell Line, Transformed; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Fluid; Female; Free Radical Scavengers; Glutamic Acid; Glycine; Humans; Interpersonal Relations; Male; Maze Learning; Microdialysis; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Schizophrenia; Xanthenes | 2008 |
Activation of medial prefrontal cortex neurons by phencyclidine is mediated via AMPA/kainate glutamate receptors in anesthetized rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Anesthetics; Animals; Drug Interactions; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Muscarinic Antagonists; Neurons; Nicotinic Antagonists; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Synaptic Transmission | 2007 |
GLT-1 expression and Glu uptake in rat cerebral cortex are increased by phencyclidine.
Topics: Animals; Cerebral Cortex; Excitatory Amino Acid Transporter 2; Glutamic Acid; Phencyclidine; Rats; Rats, Sprague-Dawley; Up-Regulation | 2008 |
Rapid cortico-limbic alterations in AMPA receptor densities after administration of PCP: implications for schizophrenia.
Topics: Amygdala; Animals; Cerebral Cortex; Dentate Gyrus; Disease Models, Animal; Down-Regulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Hippocampus; Limbic System; Muscarinic Antagonists; Phencyclidine; Rats; Rats, Sprague-Dawley; Receptor Aggregation; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Time Factors | 2008 |
Acute phencyclidine administration reduces extracellular glutamate levels and the expression of synaptophysin and SNAP-25 in rat frontal cortex.
Topics: Animals; Extracellular Fluid; Frontal Lobe; Gene Expression Regulation; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Hallucinogens; Phencyclidine; Rats; Synaptophysin; Synaptosomal-Associated Protein 25; Time Factors | 2009 |
Neurochemical changes in the rat prefrontal cortex following acute phencyclidine treatment: an in vivo localized (1)H MRS study.
Topics: Animals; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Time Factors | 2009 |
The novel neurotensin analog NT69L blocks phencyclidine (PCP)-induced increases in locomotor activity and PCP-induced increases in monoamine and amino acids levels in the medial prefrontal cortex.
Topics: Amino Acids; Animals; Antipsychotic Agents; Biogenic Monoamines; Central Nervous System Agents; Disease Models, Animal; Dopamine; Extracellular Space; Glutamic Acid; Glycine; Male; Motor Activity; Neurotensin; Norepinephrine; Peptide Fragments; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Schizophrenia; Serotonin | 2010 |
Schizophrenia-related endophenotypes in heterozygous neuregulin-1 'knockout' mice.
Topics: Animals; Aspartic Acid; Behavior, Animal; Brain; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuregulin-1; Phencyclidine; Phenotype; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Sex Factors; Social Behavior | 2010 |
Similarities in the behavior and molecular deficits in the frontal cortex between the neurotensin receptor subtype 1 knockout mice and chronic phencyclidine-treated mice: relevance to schizophrenia.
Topics: Animals; Behavior, Animal; Chromatography, High Pressure Liquid; Disease Models, Animal; Dopamine; Down-Regulation; Glutamic Acid; Immobility Response, Tonic; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Phencyclidine; Polymerase Chain Reaction; Prefrontal Cortex; Receptors, Neurotensin; RNA, Messenger; Schizophrenia; Schizophrenic Psychology; Swimming; Up-Regulation | 2010 |
Prefrontal NMDA receptor antagonism reduces impairments in pre-attentive information processing.
Topics: Animals; Cognition; Excitatory Amino Acid Antagonists; Glutamic Acid; Injections, Intraperitoneal; Male; Mice; Phencyclidine; Prefrontal Cortex; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Schizophrenia; Sensory Gating; Signal Transduction | 2011 |
Repeated phencyclidine administration alters glutamate release and decreases GABA markers in the prefrontal cortex of rats.
Topics: Animals; gamma-Aminobutyric Acid; Glutamic Acid; Male; Phencyclidine; Prefrontal Cortex; Rats; Rats, Wistar | 2012 |
Prenatal exposure to PCP produces behavioral deficits accompanied by the overexpression of GLAST in the prefrontal cortex of postpubertal mice.
Topics: Analysis of Variance; Animals; Animals, Newborn; Aspartic Acid; Behavioral Symptoms; Body Weight; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 1; Female; Gene Expression Regulation, Developmental; Glutamic Acid; Male; Mice; Mice, Inbred ICR; Microdialysis; Neurons; Phencyclidine; Potassium; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Recognition, Psychology; Swimming | 2011 |
[Development of animal models, and drug discovery for schizophrenia based on the glutamate hypothesis].
Topics: Animals; Disease Models, Animal; Drug Discovery; Glutamic Acid; Humans; Mice; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2010 |
[Development of psychotropic agents for schizophrenia based on the glutamate hypothesis].
Topics: Animals; Disease Models, Animal; Drug Discovery; Glutamic Acid; Humans; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Serine | 2010 |
Exploring metabolic pathway disruption in the subchronic phencyclidine model of schizophrenia with the Generalized Singular Value Decomposition.
Topics: Algorithms; Animals; Cluster Analysis; Cognition; Disease Models, Animal; Gene Expression Regulation; Genome; Glutamic Acid; Humans; Ligands; Models, Biological; Models, Statistical; Phencyclidine; Principal Component Analysis; Rats; Schizophrenia; Software; Systems Biology | 2011 |
Characterization of a novel particle into liquid sampler for analysis of single fluorescent aerosol particles through capillary electrophoresis.
Topics: Aerosols; Dust; Electrophoresis, Capillary; Fluorescein-5-isothiocyanate; Fluorescence; Glutamic Acid; Glycine; Lasers; Light; Scattering, Small Angle; Staining and Labeling | 2011 |
Is the acute NMDA receptor hypofunction a valid model of schizophrenia?
Topics: Animals; Corpus Callosum; Disease Models, Animal; Dopamine; Glutamic Acid; Humans; Ketamine; Parvalbumins; Phencyclidine; Receptor, Serotonin, 5-HT2A; Receptors, N-Methyl-D-Aspartate; Rodentia; Schizophrenia; Serotonin | 2012 |
Prenatal NMDA receptor antagonism impaired proliferation of neuronal progenitor, leading to fewer glutamatergic neurons in the prefrontal cortex.
Topics: Acoustic Stimulation; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavioral Symptoms; Body Weight; Bromodeoxyuridine; Cell Proliferation; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Exploratory Behavior; Female; Gene Expression Regulation, Developmental; Glutamic Acid; Male; Mice; Mice, Inbred ICR; Microdissection; Nerve Tissue Proteins; Neural Inhibition; Neural Stem Cells; Neurons; Phencyclidine; Prefrontal Cortex; Pregnancy; Prenatal Exposure Delayed Effects; Swimming | 2012 |
Effects of N-acetylaspartylglutamate (NAAG) peptidase inhibition on release of glutamate and dopamine in prefrontal cortex and nucleus accumbens in phencyclidine model of schizophrenia.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Disease Models, Animal; Dopamine; Glutamate Carboxypeptidase II; Glutamic Acid; Male; Neurotransmitter Agents; Nucleus Accumbens; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Schizophrenia | 2012 |
Twenty-five years of glutamate in schizophrenia: are we there yet?
Topics: Antipsychotic Agents; Glutamic Acid; History, 20th Century; History, 21st Century; Humans; Phencyclidine; Psychoses, Substance-Induced; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2012 |
The ultimate intra-/extra-dimensional attentional set-shifting task for mice.
Topics: Animals; Attention; Automation; Catechol O-Methyltransferase; Conditioning, Operant; Cues; Discrimination, Psychological; Dopamine; Dopamine Agents; Excitatory Amino Acid Agents; Executive Function; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phencyclidine; Phencyclidine Abuse; Psychological Tests; Reversal Learning; Task Performance and Analysis; Visual Perception | 2014 |
Neurotoxic potential of lunar and martian dust: influence on em, proton gradient, active transport, and binding of glutamate in rat brain nerve terminals.
Topics: Acridine Orange; Animals; Brain; Carbon Radioisotopes; Dust; Fluorescent Dyes; Glutamic Acid; In Vitro Techniques; Male; Mars; Membrane Potentials; Moon; Neurotoxins; Rats; Rats, Wistar; Rhodamines; Synapses; Toxicity Tests | 2013 |
Chronic phencyclidine treatment induces long-lasting glutamatergic activation of VTA dopamine neurons.
Topics: Animals; Dopaminergic Neurons; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Phencyclidine; Rats; Rats, Sprague-Dawley; Ventral Tegmental Area | 2014 |
Effects of β-Arrestin-Biased Dopamine D2 Receptor Ligands on Schizophrenia-Like Behavior in Hypoglutamatergic Mice.
Topics: Animals; Antipsychotic Agents; Arrestins; beta-Arrestins; Catalepsy; Disease Models, Animal; Dopamine Agents; Drug Evaluation, Preclinical; Female; Glutamic Acid; Male; Mice, 129 Strain; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Phencyclidine; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Schizophrenic Psychology; Social Behavior | 2016 |
Neuregulin 1 Prevents Phencyclidine-Induced Behavioral Impairments and Disruptions to GABAergic Signaling in Mice.
Topics: Animals; Behavior, Animal; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Humans; Injections, Intraventricular; Locomotion; Male; Mice; Mice, Inbred C57BL; Microdialysis; Motor Activity; Neuregulin-1; Phencyclidine; Prefrontal Cortex; Prepulse Inhibition; Reflex, Startle; Signal Transduction; Treatment Outcome | 2015 |
Down-Regulation of Hippocampal Genes Regulating Dopaminergic, GABAergic, and Glutamatergic Function Following Combined Neonatal Phencyclidine and Post-Weaning Social Isolation of Rats as a Neurodevelopmental Model for Schizophrenia.
Topics: Animals; Animals, Newborn; Behavior, Animal; Disease Models, Animal; Dopaminergic Neurons; GABAergic Neurons; Gene Expression Profiling; Gene Expression Regulation; Genetic Predisposition to Disease; Glutamic Acid; Hippocampus; Lamotrigine; Locomotion; Male; Oligonucleotide Array Sequence Analysis; Phencyclidine; Phenotype; Prepulse Inhibition; Rats, Inbred Strains; Recognition, Psychology; Reflex, Startle; Schizophrenia; Schizophrenic Psychology; Social Isolation; Sodium Channel Blockers; Synaptic Transmission; Time Factors; Triazines; Weaning | 2016 |
Trans-generation enrichment of clozapine-responsiveness trait in mice using a subchronic hypo-glutamatergic model of schizophrenia:A preliminary study.
Topics: Animals; Antipsychotic Agents; Clozapine; Disease Models, Animal; Female; Frontal Lobe; Glutamate Decarboxylase; Glutamic Acid; Hippocampus; Male; Mice; Mice, Inbred C57BL; Phencyclidine; Schizophrenia; Selective Breeding; Social Behavior | 2017 |
Effects of cariprazine on extracellular levels of glutamate, GABA, dopamine, noradrenaline and serotonin in the medial prefrontal cortex in the rat phencyclidine model of schizophrenia studied by microdialysis and simultaneous recordings of locomotor acti
Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Extracellular Fluid; gamma-Aminobutyric Acid; Glutamic Acid; Locomotion; Male; Microdialysis; Norepinephrine; Phencyclidine; Piperazines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Schizophrenia; Serotonin | 2018 |
5-HT
Topics: Acetylcholine; Animals; Antipsychotic Agents; Dopamine; Drug Partial Agonism; gamma-Aminobutyric Acid; Glutamic Acid; Lurasidone Hydrochloride; Male; Memory, Episodic; Mice; Mice, Inbred C57BL; Mice, Knockout; Phencyclidine; Receptors, Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists | 2018 |
Calbindin Deficits May Underlie Dissociable Effects of 5-HT
Topics: Animals; Behavior, Animal; Calbindins; Cognition; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Phencyclidine; Receptors, Metabotropic Glutamate; Receptors, Serotonin; Schizophrenia; Serotonin | 2020 |