glutamic acid has been researched along with methotrexate in 47 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (29.79) | 18.7374 |
| 1990's | 15 (31.91) | 18.2507 |
| 2000's | 9 (19.15) | 29.6817 |
| 2010's | 8 (17.02) | 24.3611 |
| 2020's | 1 (2.13) | 2.80 |
| Authors | Studies |
|---|---|
| Forsch, R; Rosowsky, A | 1 |
| Amano, O; Izeki, S; Kido, Y; Ogihara, T; Ono, A; Sai, Y; Satoh, E; Takanaga, H; Tamai, I; Tsuji, A; Yabuuchi, H | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| David, CL; Farnum, MF; Howell, EE; Kraut, J; Oatley, SJ; Villafranca, JE | 1 |
| Bolanowska, WE; Coward, JK; Felschow, DM; McGuire, JJ; Russell, CA; Sherwood, RF | 1 |
| Bey, P; Coward, JK; Haile, WH; McGuire, JJ | 1 |
| Galivan, J; Johnson, TB; Priest, DG; Rhee, MS | 1 |
| Cole, DE; Holcenberg, JS; Jolivet, J; Poplack, DG | 1 |
| Coward, JK; McGuire, JJ | 1 |
| Bader, H; Freisheim, JH; Moran, RG; Radike-Smith, M; Rosowsky, A; Solan, VC; Wright, JE | 1 |
| Beverley, SM; Ellenberger, TE | 1 |
| Helus, F; Knapp, WH; Layer, K; Ostertag, H; Panzer, M; Sinn, HJ | 1 |
| Booth, CL; Howell, EE; Kraut, J; Villafranca, JE; Warren, MS | 1 |
| Bader, H; Freisheim, JH; Kohler, W; Moran, RG; Rosowsky, A | 1 |
| Banerjee, RV; Coward, JK; McGuire, JJ; Shane, B | 1 |
| Fry, DW; Goldman, ID; Yalowich, JC | 1 |
| Cheng, CC; Roth, B | 1 |
| Forsch, R; Freisheim, JH; Kumar, AA; Rosowsky, A; Uren, J; Wick, M | 1 |
| Colman, PD; Forsch, RA; Moran, RG; Rosowsky, A | 1 |
| Delcamp, TJ; Freisheim, JH; Li, H; Meiering, EM; Wagner, G | 1 |
| Akimoto, H; Itoh, F; Ootsu, K; Wajima, M; Yukishige, K | 1 |
| Akaike, A; Iwata, H; Kimura, J; Ogawa, N; Shimohama, S; Tamura, Y; Tsukahara, T | 1 |
| Finiels-Marlier, F; Marini, AM; Martin, B; Paul, SM; Weller, M | 1 |
| Nagy, A; Schally, AV; Szoke, B | 1 |
| Coward, JK; Kitazume, T; McGuire, JJ; Tsukamoto, T | 1 |
| Kato, N; Matsuoka, H; Mihara, M; Miyamoto, K; Ohi, N; Takeda, Y | 1 |
| Elzein, E; Gangjee, A; McGuire, JJ; Queener, SF | 1 |
| Assaraf, YG; Goldman, ID; Zhao, R | 1 |
| Creutzig, U; Hählen, K; Jansen, G; Kaspers, GJ; Noordhuis, P; Peters, GJ; Pieters, R; Rots, MG; van Zantwijk, CH; Veerman, AJ | 1 |
| Abcouwer, SF; Lin, CM; Souba, WW | 1 |
| Gao, F; Goldman, ID; Wang, PJ; Zhao, R | 1 |
| Kabaki, M; Kakinuma, M; Kawada, K; Kawata, K; Kokuryo, Y; Kugimiya, A; Matsumoto, M; Nakatani, T; Ohtani, M; Suzuki, R | 1 |
| Achilli, L; De Lorenzi, E; Hall, AJ; Manesiotis, P; Quaglia, M; Sellergren, B | 1 |
| Denmeade, SR; Gady, AM; Gillies, SD; Lo, KM; Mhaka, A; Rosen, DM | 1 |
| Leach, F | 1 |
| Abali, EE; Banerjee, D; Bertino, JR; Menon, LG; Mishra, PJ; Peters, R; Skacel, N | 1 |
| Avila, TT; Fischer, A; Jorge, RS; Leke, R; Oliveira, DL; Portela, LV; Schmidt, AP; Souza, DO; Wofchuk, S | 1 |
| Goldman, ID; Unal, ES; Zhao, R | 1 |
| Chen, G; Fawcett, JP; Mikov, M; Tucker, IG | 1 |
| Barclay, ML; Chapman, PT; Frampton, C; James, J; O'Donnell, JL; Stamp, LK; Zhang, M | 1 |
| Coward, JK; Hyde, JE; Nzila, A; Sims, PF; Wang, P; Wang, Q; Yang, Y | 1 |
| Aghasadeghi, MR; Ardestani, MS; Barghi, Z; Cohan, RA; Hedayati, MH; Inanlou, DN; Khanahmad, H; Madadkar-Sobhani, A; Norouzian, D; Roohvand, F | 1 |
| Ali, N; Cole, PD; Gulinello, M; Vijayanathan, V | 1 |
| Huang, B; Joice, M; Kotlyar, A; Otis, J; Thomas, TP | 1 |
| Cui, Y; Hu, Q; Lin, W; Qian, G; Yang, Y | 1 |
| Bah, M; Becerra, E; Berumen-Segura, L; Escobar-Cabrera, J; Garay, E; García-Alcocer, G; Hernández-Pérez, A; Mendoza-Santiago, A | 1 |
| Abdellatif, AAH; Aldubayan, MA; Alhowail, AH; Almogbel, YS; Chigurupati, S; Nemala, RA | 1 |
1 review(s) available for glutamic acid and methotrexate
| Article | Year |
|---|---|
Recent progress in the medicinal chemistry of 2,4-diaminopyrimidines.
Topics: Amino Acid Sequence; Animals; Folic Acid Antagonists; Glutamates; Glutamic Acid; Malaria; Mathematics; Methotrexate; Microbial Sensitivity Tests; Models, Chemical; Pyrimethamine; Pyrimidines; Quinazolines; Stereoisomerism; Triazines | 1982 |
2 trial(s) available for glutamic acid and methotrexate
| Article | Year |
|---|---|
Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia.
Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Drug Resistance, Neoplasm; Female; gamma-Glutamyl Hydrolase; Glutamic Acid; Humans; Infant; Male; Methotrexate; Peptide Synthases; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1999 |
Methotrexate polyglutamate concentrations are not associated with disease control in rheumatoid arthritis patients receiving long-term methotrexate therapy.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Erythrocyte Count; Erythrocytes; Female; Folic Acid; Glutamic Acid; Humans; Joints; Male; Methotrexate; Middle Aged; Polyglutamic Acid; Young Adult | 2010 |
44 other study(ies) available for glutamic acid and methotrexate
| Article | Year |
|---|---|
Methotrexate analogues. 16. Importance of the side-chain amide carbonyl group as a structural determinant of biological activity.
Topics: Animals; Binding, Competitive; Cell Survival; Chemical Phenomena; Chemistry; Folic Acid Antagonists; Lacticaseibacillus casei; Leukemia L1210; Methotrexate; Mice; Structure-Activity Relationship | 1982 |
Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT1.
Topics: Amino Acid Sequence; Animals; Benzoic Acid; Biological Transport; Carboxylic Acids; Carrier Proteins; Cell Line; Digestive System; Hydrogen-Ion Concentration; Immunohistochemistry; Intestinal Absorption; Lactic Acid; Molecular Sequence Data; Monocarboxylic Acid Transporters; Rats; Tissue Distribution; Transfection | 1999 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Structure and function of alternative proton-relay mutants of dihydrofolate reductase.
Topics: Asparagine; Binding Sites; Crystallography; Escherichia coli; Glutamates; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Kinetics; Methotrexate; Mutagenesis, Site-Directed; Protons; Pteridines; Spectrophotometry, Ultraviolet; Tetrahydrofolate Dehydrogenase | 1992 |
Biochemical and biological properties of methotrexate analogs containing D-glutamic acid or D-erythro, threo-4-fluoroglutamic acid.
Topics: Cell Division; Cell Line; Folic Acid Antagonists; gamma-Glutamyl Hydrolase; Glutamates; Glutamic Acid; Humans; Methotrexate; Stereoisomerism; Thymidine Monophosphate | 1991 |
DL-3,3-difluoroglutamate: an enhancer of folylpolyglutamate elongation.
Topics: Animals; Folic Acid; Glutamates; Glutamic Acid; Kinetics; Liver; Methotrexate; Peptide Synthases; Pteroylpolyglutamic Acids; Rats; Substrate Specificity | 1990 |
The effect of methionine on methotrexate metabolism in rat hepatocytes in monolayer culture.
Topics: Animals; Cells, Cultured; Folic Acid; Glutamates; Glutamic Acid; Hydroxylation; Liver; Male; Methionine; Methotrexate; Rats; Rats, Inbred Lew | 1989 |
Prevention of methotrexate cytotoxicity by asparaginase inhibition of methotrexate polyglutamate formation.
Topics: Animals; Asparaginase; Asparagine; Biological Transport; Cell Survival; DNA Replication; Glutamates; Glutamic Acid; Glutamine; Kinetics; Leukemia L5178; Leukemia, Experimental; Methotrexate; Mice; Peptides; Polyglutamic Acid | 1985 |
DL-threo-4-fluoroglutamic acid. A chain-terminating inhibitor of folylpolyglutamate synthesis.
Topics: Animals; Chickens; Chromatography, High Pressure Liquid; Glutamates; Glutamic Acid; Isomerism; Liver; Methotrexate; Peptide Synthases; Rats; Swine | 1985 |
Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chain.
Topics: Aminobutyrates; Aminopterin; Animals; beta-Alanine; Cell Division; Folic Acid Antagonists; Glutamates; Glutamic Acid; Kinetics; Leukemia L1210; Methotrexate; Mice; Molecular Weight; Ornithine; Peptide Synthases | 1986 |
Biochemistry and regulation of folate and methotrexate transport in Leishmania major.
Topics: 4-Aminobenzoic Acid; Animals; Biological Transport, Active; Deoxyglucose; Folic Acid; Glutamates; Glutamic Acid; Kinetics; Leishmania tropica; Leucovorin; Methotrexate | 1987 |
Effect of methotrexate on perfusion and nitrogen-13 glutamate uptake in the Walker-256 carcinosarcoma.
Topics: Animals; Butanols; Carbon Radioisotopes; Carcinoma 256, Walker; Glutamates; Glutamic Acid; Methotrexate; Nitrogen Radioisotopes; Rats; Tissue Distribution | 1988 |
Construction of an altered proton donation mechanism in Escherichia coli dihydrofolate reductase.
Topics: Escherichia coli; Genes; Genes, Bacterial; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Mathematics; Methotrexate; Mutation; Protein Binding; Protons; Serine; Tetrahydrofolate Dehydrogenase | 1987 |
Methotrexate analogues. 34. Replacement of the glutamate moiety in methotrexate and aminopterin by long-chain 2-aminoalkanedioic acids.
Topics: Amino Acids, Dicarboxylic; Aminopterin; Animals; Cell Division; Chemical Phenomena; Chemistry; Drug Resistance; Folic Acid Antagonists; Glutamates; Glutamic Acid; Humans; Leukemia L1210; Liver; Methotrexate; Mice; Peptide Synthases; Structure-Activity Relationship; Tumor Cells, Cultured | 1988 |
Dihydrofolate synthetase and folylpolyglutamate synthetase: direct evidence for intervention of acyl phosphate intermediates.
Topics: Animals; Catalysis; Escherichia coli; Folic Acid; Glutamates; Glutamic Acid; Liver; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methotrexate; Organophosphates; Oxygen; Oxygen Isotopes; Peptide Synthases; Phosphates; Pterins; Rats; Swine | 1988 |
Rapid formation of poly-gamma-glutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascites tumor cell in vitro.
Topics: Animals; Biological Transport; Carcinoma, Ehrlich Tumor; Chromatography, High Pressure Liquid; Folic Acid; Glutamates; Glutamic Acid; Glutamine; Kinetics; Male; Methotrexate; Mice; Pteroylpolyglutamic Acids; Tetrahydrofolate Dehydrogenase | 1982 |
Methotrexate analogues. 20. Replacement of glutamate by longer-chain amino diacids: effects on dihydrofolate reductase inhibition, cytotoxicity, and in vivo antitumor activity.
Topics: Animals; Antineoplastic Agents; Folic Acid Antagonists; Glutamates; Glutamic Acid; Lacticaseibacillus casei; Leukemia L1210; Methotrexate; Mice | 1983 |
A mechanism for the addition of multiple moles of glutamate by folylpolyglutamate synthetase.
Topics: Animals; Binding Sites; Carboxypeptidases; Female; gamma-Glutamyl Hydrolase; Glutamates; Glutamic Acid; Liver; Methotrexate; Mice; Mice, Inbred Strains; Protein Binding; Substrate Specificity | 1984 |
Contributions of tryptophan 24 and glutamate 30 to binding long-lived water molecules in the ternary complex of human dihydrofolate reductase with methotrexate and NADPH studied by site-directed mutagenesis and nuclear magnetic resonance spectroscopy.
Topics: Amino Acid Sequence; Glutamic Acid; Humans; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Methotrexate; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; NADP; Recombinant Proteins; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Tryptophan; Water | 1995 |
Non-glutamate type pyrrolo[2,3-d]pyrimidine antifolates. I: Synthesis and biological properties of pyrrolo[2,3-d]pyrimidine antifolates containing tetrazole congener of glutamic acid.
Topics: Animals; Antineoplastic Agents; Cell Division; Fibrosarcoma; Folic Acid Antagonists; Glutamic Acid; Magnetic Resonance Spectroscopy; Methotrexate; Mice; Structure-Activity Relationship; Tetrazoles; Tumor Cells, Cultured | 1995 |
Protective effect of nerve growth factor against glutamate-induced neurotoxicity in cultured cortical neurons.
Topics: Animals; Cells, Cultured; Cerebral Cortex; CHO Cells; Cricetinae; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Humans; Methotrexate; Mice; Nerve Growth Factors; Neurites; Neurons; Neurotoxins; PC12 Cells; Promoter Regions, Genetic; Recombinant Proteins; Simian virus 40; Tetrahydrofolate Dehydrogenase; Transfection | 1993 |
MK-801 and memantine protect cultured neurons from glutamate toxicity induced by glutamate carboxypeptidase-mediated cleavage of methotrexate.
Topics: Animals; Astrocytes; Brain; Carboxypeptidases; Cells, Cultured; Cerebellum; Cerebral Cortex; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Memantine; Methotrexate; Neurons; Rats; Rats, Sprague-Dawley | 1993 |
Selective coupling of methotrexate to peptide hormone carriers through a gamma-carboxamide linkage of its glutamic acid moiety: benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate activation in salt coupling.
Topics: Amino Acid Sequence; Drug Carriers; Glutamates; Glutamic Acid; Gonadotropin-Releasing Hormone; Methotrexate; Molecular Sequence Data; Organophosphorus Compounds; Somatostatin | 1993 |
Synthesis and biological evaluation of DL-4,4-difluoroglutamic acid and DL-gamma,gamma-difluoromethotrexate.
Topics: Aminopterin; Cell Division; Cell Line; Chromatography, High Pressure Liquid; Folic Acid Antagonists; Glutamates; Glutamic Acid; Humans; Kinetics; Magnetic Resonance Spectroscopy; Methotrexate; Molecular Structure; Peptide Synthases; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 1996 |
Antirheumatic agents. III. Novel methotrexate derivatives bearing an indoline ring and a modified ornithine or glutamic acid.
Topics: Antirheumatic Agents; Cell Division; Glutamic Acid; Humans; Indoles; Leukocytes, Mononuclear; Methotrexate; Ornithine; Structure-Activity Relationship | 1997 |
Synthesis and biological activities of tricyclic conformationally restricted tetrahydropyrido annulated furo[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antimetabolites, Antineoplastic; Cell Division; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Glutamic Acid; Humans; Liver; Methotrexate; Mycobacterium avium; Pneumocystis; Pyrimidines; Rats; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Toxoplasma; Tumor Cells, Cultured | 1998 |
A mutated murine reduced folate carrier (RFC1) with increased affinity for folic acid, decreased affinity for methotrexate, and an obligatory anion requirement for transport function.
Topics: Amino Acid Substitution; Animals; Anions; Binding Sites; Biological Transport, Active; Carrier Proteins; Drug Resistance, Neoplasm; Folic Acid; Glutamic Acid; Kinetics; Leukemia L1210; Lysine; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Mutagenesis, Site-Directed; Protein Structure, Secondary; Structure-Activity Relationship; Tumor Cells, Cultured | 1998 |
Effect of dietary glutamate on chemotherapy-induced immunosuppression.
Topics: Animals; Antineoplastic Agents; Diet; Female; Glutamic Acid; Glutamine; Glutathione; Hypersensitivity, Delayed; Immunologic Deficiency Syndromes; Lymphocyte Activation; Methotrexate; Rats; Rats, Inbred F344 | 1999 |
Role of the amino acid 45 residue in reduced folate carrier function and ion-dependent transport as characterized by site-directed mutagenesis.
Topics: Amino Acid Substitution; Animals; Anions; Antimetabolites, Antineoplastic; Biological Transport; Carrier Proteins; Folic Acid; Glutamic Acid; Leucovorin; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Mutagenesis, Site-Directed; Reduced Folate Carrier Protein; Tetrahydrofolates; Transfection; Tumor Cells, Cultured | 2000 |
New gamma-fluoromethotrexates modified in the pteridine ring: synthesis and in vitro immunosuppressive activity.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; B-Lymphocytes; Folic Acid Antagonists; Glutamic Acid; Humans; Immunosuppressive Agents; Methotrexate; Mitogens; Molecular Structure; Pteridines; Pyrimidines; T-Lymphocytes | 2000 |
A substructure approach toward polymeric receptors targeting dihydrofolate reductase inhibitors. 2. Molecularly imprinted polymers against Z-l-glutamic acid showing affinity for larger molecules.
Topics: Enzyme Inhibitors; Folic Acid Antagonists; Glutamic Acid; Magnetic Resonance Spectroscopy; Methotrexate; Polymers; Tetrahydrofolate Dehydrogenase | 2003 |
Use of methotrexate-based peptide substrates to characterize the substrate specificity of prostate-specific membrane antigen (PSMA).
Topics: Animals; Antigens, Surface; Aspartic Acid; Blotting, Western; Extracellular Fluid; Glutamate Carboxypeptidase II; Glutamic Acid; Humans; Immunoglobulin gamma-Chains; Immunoglobulin kappa-Chains; Male; Methotrexate; Mice; Peptide Fragments; Prodrugs; Prostatic Neoplasms; Recombinant Fusion Proteins; Substrate Specificity; Tumor Cells, Cultured | 2004 |
Targeting prostate-specific membrane antigen in cancer therapy: can molecular medicine be brought to the surface?
Topics: Antigens, Surface; Aspartic Acid; Drug Delivery Systems; Glutamate Carboxypeptidase II; Glutamic Acid; Humans; Male; Methotrexate; Peptide Fragments; Prodrugs; Prostatic Neoplasms; Recombinant Fusion Proteins; Substrate Specificity | 2004 |
Identification of amino acids required for the functional up-regulation of human dihydrofolate reductase protein in response to antifolate Treatment.
Topics: Amino Acids; Animals; Binding Sites; Blotting, Western; Catalysis; Cell Survival; CHO Cells; Cloning, Molecular; Cricetinae; Cysteine; DNA Primers; Folic Acid Antagonists; Gene Expression Regulation, Enzymologic; Glutamic Acid; Glutathione Transferase; Green Fluorescent Proteins; Humans; Inhibitory Concentration 50; Kinetics; Leucine; Methotrexate; Microscopy, Fluorescence; Models, Biological; Mutagenesis, Site-Directed; Mutation; NADP; Protein Biosynthesis; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine; Spectrophotometry; Tetrahydrofolate Dehydrogenase; Time Factors; Transcription, Genetic; Transfection; Up-Regulation | 2005 |
Methotrexate induces seizure and decreases glutamate uptake in brain slices: prevention by ionotropic glutamate receptors antagonists and adenosine.
Topics: Adenosine; Animals; Brain; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Methotrexate; Mice; Neuroprotective Agents; Quinoxalines; Seizures | 2006 |
Role of the glutamate 185 residue in proton translocation mediated by the proton-coupled folate transporter SLC46A1.
Topics: Amino Acid Sequence; Cell Membrane; Conserved Sequence; Evolution, Molecular; Folic Acid; Glutamic Acid; HeLa Cells; Humans; Hydrogen-Ion Concentration; Kinetics; Leucovorin; Membrane Transport Proteins; Methotrexate; Models, Biological; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Protein Conformation; Proton-Coupled Folate Transporter; Structure-Activity Relationship; Transfection | 2009 |
Simultaneous determination of methotrexate and its polyglutamate metabolites in Caco-2 cells by liquid chromatography-tandem mass spectrometry.
Topics: Caco-2 Cells; Chromatography, High Pressure Liquid; Glutamic Acid; Humans; Methotrexate; Reproducibility of Results; Tandem Mass Spectrometry | 2009 |
Characterisation of the bifunctional dihydrofolate synthase-folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition.
Topics: Adenosine Triphosphate; Enzyme Inhibitors; Folic Acid; Glutamic Acid; Kinetics; Methotrexate; Peptide Synthases; Plasmodium falciparum; Protozoan Proteins; Pterins; Substrate Specificity; Tetrahydrofolates | 2010 |
Design, modeling, expression, and chemoselective PEGylation of a new nanosize cysteine analog of erythropoietin.
Topics: Animals; Cell Line; Cell Proliferation; CHO Cells; Chromatography, Gel; Cloning, Molecular; Computer Simulation; Cricetinae; Cricetulus; Cysteine; Drug Delivery Systems; Erythropoietin; Glutamic Acid; Humans; Methotrexate; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Nanoparticles; Polyethylene Glycols; Protein Binding; Protein Stability; Recombinant Proteins; Spectroscopy, Fourier Transform Infrared | 2011 |
Persistent cognitive deficits, induced by intrathecal methotrexate, are associated with elevated CSF concentrations of excitotoxic glutamate analogs and can be reversed by an NMDA antagonist.
Topics: Animals; Cognition Disorders; Dextromethorphan; Disease Models, Animal; Excitatory Amino Acid Antagonists; Folic Acid; Glutamic Acid; Homocysteine; Humans; Injections, Spinal; Male; Memory Disorders; Methotrexate; Rats; Rats, Long-Evans; Recognition, Psychology | 2011 |
PSMA-targeted stably linked "dendrimer-glutamate urea-methotrexate" as a prostate cancer therapeutic.
Topics: Antigens, Surface; Click Chemistry; Dendrimers; Drug Delivery Systems; Glutamate Carboxypeptidase II; Glutamic Acid; Humans; Male; Methotrexate; Nanoparticles; Prostatic Neoplasms; Urea | 2014 |
A biocompatible metal-organic framework as a pH and temperature dual-responsive drug carrier.
Topics: Animals; Antimetabolites, Antineoplastic; Biocompatible Materials; Cell Proliferation; Crystallography, X-Ray; Drug Carriers; Drug Screening Assays, Antitumor; Glutamic Acid; Hydrogen-Ion Concentration; Metal-Organic Frameworks; Methotrexate; Models, Molecular; Optical Imaging; PC12 Cells; Rats; Temperature; Tumor Cells, Cultured; Zinc | 2018 |
Glutamic Acid Increased Methotrexate Polyglutamation and Cytotoxicity in a CCRF-SB Acute Lymphoblastic Leukemia Cell Line.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line; Cell Line, Tumor; Glutamic Acid; Humans; Methotrexate; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2019 |
Effects of CMF and MET on glutamate and dopamine levels in the brain, and their impact on cognitive function.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain; Breast Neoplasms; Cognition; Cyclophosphamide; Diabetes Mellitus, Type 2; Dopamine; Female; Fluorouracil; Glutamic Acid; Humans; Metformin; Methotrexate; Rats | 2022 |