glutamic acid has been researched along with methionine sulfoximine in 69 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (24.64) | 18.7374 |
| 1990's | 22 (31.88) | 18.2507 |
| 2000's | 15 (21.74) | 29.6817 |
| 2010's | 13 (18.84) | 24.3611 |
| 2020's | 2 (2.90) | 2.80 |
| Authors | Studies |
|---|---|
| Farinelli, SE; Nicklas, WJ | 1 |
| Engelsen, BA; Fonnum, F; Furset, K | 1 |
| Ertan, H | 1 |
| Bridges, RJ; Cotman, CW; Hatalski, CG; Koh, JY | 1 |
| Enger, MD; Kang, YJ | 1 |
| Beckstead, RM; Somers, DL | 2 |
| Bosman, DK; Bovée, WM; Chamuleau, RA; De Graaf, AA; Deutz, NE; Jörning, GG; Maas, MA; Van Eijk, HM; vd Hulst, RW | 1 |
| Farrow, NA; Kanamori, K; Parivar, F; Ross, BD | 1 |
| Rothstein, JD; Tabakoff, B | 2 |
| Durschlag, RP; Smith, RJ | 1 |
| Engelsen, B; Fonnum, F | 1 |
| Bonanni, LC; Divo, AA; Geary, TG; Jensen, JB | 1 |
| Rider, CC | 1 |
| Colanduoni, J; Nissan, R; Villafranca, JJ | 1 |
| Blackburn, MB; Ginsburg, A; Gorman, EG; Neece, SH | 1 |
| Hoop, B; Kazemi, H; Shih, VE; Systrom, DM | 1 |
| Griffith, OW | 1 |
| Chapman, JS; Meeks, JC | 1 |
| Eybalin, M; Pujol, R | 1 |
| Anderson, PM; Casey, CA | 1 |
| Alvarez, ME; McCarthy, CM | 1 |
| Murthy, CR; Subbalakshmi, GY | 1 |
| Boustani, MR; Fanburg, BL; Hassoun, PM; Maloney, EK; White, AC | 1 |
| Escalante, L; Gonzalez, R; Islas, L; Obregon, AM; Sanchez, S | 1 |
| Eisenberg, D; Liaw, SH | 1 |
| Ishita, S; Kato, S; Mawatari, K; Sugawara, K | 1 |
| Exposito, I; Mora, F; Porras, A; Sanz, B | 1 |
| Petersen, SB; Schousboe, A; Sonnewald, U; Svendsen, JS; Unsgård, G; Westergaard, N | 1 |
| Brookes, N | 1 |
| Kang, YJ | 1 |
| Colquhoun, A; Newsholme, EA | 1 |
| Bot, AP; Corner, MA | 1 |
| Harth, G; Horwitz, MA | 1 |
| Clemente, MT; Márquez, AJ | 1 |
| Fliniaux, MA; Gillet-Manceau, F; Marty, D; Mesnard, F; Monti, JP | 1 |
| Bains, JS; Curry, K; Pasqualotto, BA; Shaw, CA | 1 |
| Attwell, D; Grant, J; Marcaggi, P; Mort, D | 1 |
| Blin, M; Cloix, JF; Crusio, WE; Hévor, T | 1 |
| Bains, JS; Shaw, CA | 1 |
| Crespo, JL; Fowler, B; Hall, MN; Powers, T | 1 |
| Näsholm, T; Persson, J | 1 |
| Ben-Dror, I; Shaked, I; Vardimon, L | 1 |
| Bering, J; Böttcher, T; Domhof, S; Goiny, M; Nau, R; Ungerstedt, U | 1 |
| PETERS, EL; TOWER, DB | 1 |
| Park, C; Shin, D | 1 |
| Albrecht, J; Law, RO; Stafiej, A; Zielińska, M | 1 |
| Benz, AM; Ishikawa, M; Izumi, M; Izumi, Y; Matsukawa, M; Olney, JW; Zorumski, CF | 1 |
| Alonso, TJ; Castro Fuentes, R; Garcia Dopico, J; Gonzalez Hernández, T; Perdomo Diaz, J; Rodríguez Díaz, M; Sabate, M | 1 |
| Kam, K; Nicoll, R | 1 |
| Huang, Z; Liang, M; Peng, J; Wang, X; Xing, T | 1 |
| Ni, Y; Parpura, V | 1 |
| Acosta, ML; Bui, BV; Donaldson, P; Hu, RG; Kalloniatis, M; Vingrys, AJ | 1 |
| Bame, M; Brusilow, WS; Galloway, MP; Ghoddoussi, F; Jambekar, A; Needleman, R | 1 |
| Bidmon, HJ; Cremer, CM; Escobar, JL; Görg, B; Palomero-Gallagher, N; Speckmann, EJ; Zilles, K | 1 |
| Ghanizadeh, A | 1 |
| Donaldson, PJ; Hu, RG; Kalloniatis, M; Lim, JC | 1 |
| Ishikawa, M; Izumi, Y; Yoshitomi, T; Zorumski, CF | 1 |
| Bergersen, LH; Chaudhry, FA; Eid, T; Kang, D; Lauritzen, F; Lee, TS; Ottersen, OP; Perez, EL; Wang, Y; Zaveri, HP | 1 |
| Chen, Z; Fan, YY; Fang, Q; He, P; Hu, WW; Ohtsu, H; Xu, TL; Xu, ZH; Yan, HJ; Yang, Y; Zhang, CY; Zhang, XN; Zhong, K | 1 |
| Iwata, K; Kitagawa, J; Mostafeezur, RM; Shinoda, M; Takahashi, K; Takatsuji, H; Unno, S; Yamada, Y; Yamamura, K; Zakir, HM | 1 |
| Ahn, DK; Bae, YC; Ju, JS; Kim, MJ; Kim, ST; Mun, JH; Park, KD; Yang, KY | 1 |
| Forchhammer, K; Gloge, F; Hauf, K; Kayumov, A | 1 |
| Andersen, JV; McNair, LF; Schousboe, A; Waagepetersen, HS | 1 |
| Cajueiro, DBB; de Barros Pita, W; de Morais Junior, MA; Leite, FCB; Parente, DC | 1 |
| Baek, JH; Cho, GJ; Choi, WS; Jung, DH; Kang, SS; Kim, HJ; Kim, S; Lee, DH; Lee, DK; Roh, GS; Son, H | 1 |
| Acewicz, A; Albrecht, J; Czarnecka, AM; Czuczwar, SJ; Kołodziej, M; Obara-Michlewska, M; Pawlik, MJ; Popek, MP; Wierzba-Bobrowicz, T; Łuszczki, J | 1 |
| Albrecht, J; Aldana, BI; Belfiori-Carrasco, LF; Czarnecka, AM; Obara-Michlewska, M; Pawlik, MJ; Popek, MP | 1 |
69 other study(ies) available for glutamic acid and methionine sulfoximine
| Article | Year |
|---|---|
Glutamate metabolism in rat cortical astrocyte cultures.
Topics: Aminooxyacetic Acid; Animals; Astrocytes; Cells, Cultured; Cerebral Cortex; Drug Combinations; Glutamates; Glutamic Acid; Methionine Sulfoximine; Rats | 1992 |
Changes in the levels of glutamate and related amino acids in the intact and decorticated rat neostriatum during various conditions associated with convulsions.
Topics: 2-Amino-5-phosphonovalerate; Acetates; Amino Acids; Animals; Anticonvulsants; Brain Mapping; Caudate Nucleus; Cerebral Cortex; Cerebral Decortication; Corpus Striatum; Electroencephalography; Epilepsy, Tonic-Clonic; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutaminase; Hypoglycemia; Insulin; Male; Methionine Sulfoximine; Penicillin G; Putamen; Rats; Rats, Wistar; Seizures; Synaptic Transmission | 1992 |
The effect of various culture conditions on the levels of ammonia assimilatory enzymes of Corynebacterium callunae.
Topics: Ammonia; Corynebacterium; Culture Media; Fumarates; Glucose; Glutamate Dehydrogenase; Glutamate Synthase; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Kinetics; Malates; Methionine Sulfoximine | 1992 |
Increased excitotoxic vulnerability of cortical cultures with reduced levels of glutathione.
Topics: Animals; Antimetabolites; Buthionine Sulfoximine; Cerebral Cortex; Female; Glutamates; Glutamic Acid; Glutathione; L-Lactate Dehydrogenase; Methionine Sulfoximine; Mice; N-Methylaspartate; Pregnancy | 1991 |
Increased glutathione levels in quiescent, serum-stimulated NRK-49F cells are associated not with a response to growth factors but with nutrient repletion.
Topics: Animals; Blood; Buthionine Sulfoximine; Cell Division; Cell Line; Culture Media; Cysteine; DNA; Epidermal Growth Factor; Glutamates; Glutamic Acid; Glutathione; Growth Substances; Interphase; Methionine Sulfoximine | 1991 |
Striatal preprotachykinin and preproenkephalin mRNA levels and the levels of nigral substance P and pallidal Met5-enkephalin depend on corticostriatal axons that use the excitatory amino acid neurotransmitters aspartate and glutamate: quantitative radioim
Topics: Animals; Aspartic Acid; Axons; Brain Chemistry; Cerebral Cortex; Corpus Striatum; Enkephalins; Gene Expression Regulation; Globus Pallidus; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Male; Methionine Sulfoximine; Neurotransmitter Agents; Nucleic Acid Hybridization; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger; Substance P; Substantia Nigra; Synaptic Transmission; Tachykinins | 1990 |
Changes in brain metabolism during hyperammonemia and acute liver failure: results of a comparative 1H-NMR spectroscopy and biochemical investigation.
Topics: Acute Disease; Ammonia; Animals; Brain; Brain Diseases; Electroencephalography; Glutamates; Glutamic Acid; Ischemia; Lactates; Lactic Acid; Liver Circulation; Liver Diseases; Magnetic Resonance Spectroscopy; Male; Methionine Sulfoximine; Protons; Rats; Rats, Inbred Strains; Urease | 1990 |
A 15N-n.m.r. study of cerebral, hepatic and renal nitrogen metabolism in hyperammonaemic rats.
Topics: Adenosine Triphosphate; Alanine; Ammonia; Animals; Brain; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutamine; Inactivation, Metabolic; Kidney; Liver; Magnetic Resonance Spectroscopy; Male; Methionine Sulfoximine; Nitrogen; Nitrogen Isotopes; Phosphocreatine; Rats; Rats, Inbred Strains; Urea | 1990 |
Chronic methionine sulfoximine administration reduces synaptosomal aspartate and glutamate in rat striatum.
Topics: Animals; Aspartic Acid; Brain; Corpus Striatum; Enzyme Inhibitors; Glutamates; Glutamic Acid; Male; Methionine Sulfoximine; Neurotransmitter Agents; Rats; Rats, Inbred Strains; Synaptosomes | 1990 |
Glial and neuronal glutamate transport following glutamine synthetase inhibition.
Topics: Animals; Biological Transport; Corpus Striatum; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; In Vitro Techniques; Kinetics; Male; Methionine Sulfoximine; Neuroglia; Neurons; Rats; Synaptosomes | 1985 |
Regulation of glutamine production by skeletal muscle cells in culture.
Topics: Animals; Animals, Newborn; Cells, Cultured; Culture Media; Diazooxonorleucine; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutaminase; Glutamine; Methionine Sulfoximine; Muscles; Rats; Rats, Inbred Strains | 1985 |
The effect of methioninesulfoximine, an inhibitor of glutamine synthetase, on the levels of amino acids in the intact and decorticated rat neostriatum.
Topics: Alanine; Amino Acids; Animals; Brain Chemistry; Cerebral Decortication; Corpus Striatum; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Nutritional requirements of Plasmodium falciparum in culture. III. Further observations on essential nutrients and antimetabolites.
Topics: 4-Aminobenzoic Acid; Animals; Antimetabolites; Biotin; Buthionine Sulfoximine; Carbohydrate Metabolism; Culture Media; Dipyridamole; Folic Acid; Glutamates; Glutamic Acid; Hypoxanthine; Hypoxanthines; Isoniazid; Leucovorin; Methionine Sulfoximine; Plasmodium falciparum; Purines; Pyridoxine; Sulfonamides | 1985 |
Apparent inhibition of ATP citrate lyase by L-glutamate in vitro is due to the presence of glutamine synthetase.
Topics: Adenosine Triphosphate; Animals; ATP Citrate (pro-S)-Lyase; Brain; Chromatography, Affinity; Chromatography, Gel; Citrates; Citric Acid; Female; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Liver; Malate Dehydrogenase; Methionine Sulfoximine; NAD; Rats; Rats, Inbred Strains | 1986 |
Studies of the mechanism of glutamine synthetase utilizing pH-dependent behavior in catalysis and binding.
Topics: Adenosine Triphosphate; Amino Acids; Ammonia; Catalysis; Chemical Phenomena; Chemistry; Escherichia coli; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Homocysteine; Hydrogen-Ion Concentration; Hydroxylamine; Hydroxylamines; Kinetics; Lysine; Methionine Sulfoximine; Protons; Spectrometry, Fluorescence; Substrate Specificity; Sulfonamides | 1987 |
Thermodynamics of active-site ligand binding to Escherichia coli glutamine synthetase.
Topics: Adenylyl Imidodiphosphate; Binding Sites; Calorimetry; Escherichia coli; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Kinetics; Ligands; Macromolecular Substances; Methionine Sulfoximine; Spectrometry, Fluorescence | 1987 |
Central respiratory effects of glutamine synthesis inhibition in dogs.
Topics: Animals; Central Nervous System; Chemoreceptor Cells; Dogs; Female; gamma-Aminobutyric Acid; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutamine; Male; Methionine Sulfoximine; Models, Biological; Neurotransmitter Agents; Respiration | 1988 |
Glutathione turnover in human erythrocytes. Inhibition by buthionine sulfoximine and incorporation of glycine by exchange.
Topics: Buthionine Sulfoximine; Cysteine; Erythrocytes; Glutamates; Glutamic Acid; Glutathione; Glycine; Humans; Kinetics; Methionine Sulfoximine | 1981 |
Glutamine and glutamate transport by Anabaena variabilis.
Topics: Biological Transport; Cyanobacteria; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutamine; Kinetics; Methionine Sulfoximine; Mutation | 1983 |
A radioautographic study of [3H]L-glutamate and [3H]L-glutamine uptake in the guinea-pig cochlea.
Topics: Absorption; Animals; Autoradiography; Cochlea; Glutamates; Glutamic Acid; Glutamine; Guinea Pigs; Hair Cells, Auditory; In Vitro Techniques; Methionine Sulfoximine; Neurotransmitter Agents; Sodium | 1983 |
Glutamine-dependent synthesis of citrulline by isolated hepatic mitochondria from Squalus acanthias.
Topics: Ammonia; Ammonium Chloride; Animals; Citrulline; Dogfish; Glutamates; Glutamic Acid; Glutamine; Isoxazoles; Methionine Sulfoximine; Mitochondria, Liver | 1984 |
Glutamine synthetase from Mycobacterium avium.
Topics: Ammonium Chloride; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutamine; Hydrogen-Ion Concentration; Isoelectric Point; Methionine Sulfoximine; Molecular Weight; Mycobacterium; Mycobacterium avium; Peptides; Temperature | 1984 |
Suppression of the enzymes of glutamate metabolism in cortical synaptosomes in methionine sulfoximine toxicity.
Topics: Alanine Transaminase; Ammonia; Animals; Aspartate Aminotransferases; Cerebral Cortex; Female; Glutamate Dehydrogenase; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Male; Methionine Sulfoximine; Rats; Rats, Inbred Strains; Synaptosomes | 1984 |
Alteration of striatal glutamate release after glutamine synthetase inhibition.
Topics: Animals; Calcium; Corpus Striatum; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Kinetics; Male; Methionine Sulfoximine; Potassium; Rats; Rats, Inbred Strains | 1984 |
Nitric oxide increases cellular glutathione levels in rat lung fibroblasts.
Topics: Animals; Arginine; Buthionine Sulfoximine; Cattle; Cell Line; Endothelium, Vascular; Enzyme Inhibitors; Fibroblasts; Glutamate-Cysteine Ligase; Glutamic Acid; Glutathione; Isosorbide Dinitrate; Lung; Methionine Sulfoximine; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Pulmonary Artery; Rats; Vasodilator Agents | 1995 |
Gentamicin formation in Micromonospora purpurea: stimulatory effect of ammonium.
Topics: Ammonium Chloride; Fermentation; Gentamicins; Glutamic Acid; Glutamine; Methionine Sulfoximine; Micromonospora | 1995 |
Structural model for the reaction mechanism of glutamine synthetase, based on five crystal structures of enzyme-substrate complexes.
Topics: Adenylyl Imidodiphosphate; Crystallography, X-Ray; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutamine; Methionine Sulfoximine; Models, Chemical; Models, Molecular; Protein Conformation; Quaternary Ammonium Compounds; Salmonella typhimurium | 1994 |
Cystine/glutamate antiporter expression in retinal Müller glial cells: implications for DL-alpha-aminoadipate toxicity.
Topics: 2-Aminoadipic Acid; Animals; Antimetabolites; Autoradiography; Buthionine Sulfoximine; Carps; Carrier Proteins; Chlorides; Chromatography, High Pressure Liquid; Cystine; Electroretinography; Glutamates; Glutamic Acid; Glutathione; Isomerism; Methionine Sulfoximine; Neuroglia; Retina; Sodium; Sulfur Radioisotopes | 1993 |
Effects of apomorphine and L-methionine sulphoximine on the release of excitatory amino acid neurotransmitters and glutamine in the striatum of the conscious rat.
Topics: Analysis of Variance; Animals; Apomorphine; Aspartic Acid; Corpus Striatum; Glutamates; Glutamic Acid; Glutamine; Haloperidol; Kinetics; Male; Methionine Sulfoximine; Neurotransmitter Agents; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1994 |
Direct demonstration by [13C]NMR spectroscopy that glutamine from astrocytes is a precursor for GABA synthesis in neurons.
Topics: Acetates; Animals; Astrocytes; Cells, Cultured; Cerebral Cortex; gamma-Aminobutyric Acid; Gas Chromatography-Mass Spectrometry; Glucose; Glutamate-Ammonia Ligase; Glutamates; Glutamic Acid; Glutamine; Magnetic Resonance Spectroscopy; Methionine Sulfoximine; Mice; Neurons | 1993 |
Interaction between the glutamine cycle and the uptake of large neutral amino acids in astrocytes.
Topics: Amino Acids; Ammonia; Animals; Astrocytes; Glutamates; Glutamic Acid; Glutamine; Kynurenine; Methionine Sulfoximine; Mice; Phenylalanine | 1993 |
Buthionine sulfoximine enhances glutathione-but attenuates glutamate-stimulated cell proliferation.
Topics: Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Carcinoma; Cell Division; Culture Media; Enzyme Inhibitors; Glutamic Acid; Glutathione; Humans; Lung Neoplasms; Methionine Sulfoximine; Tumor Cells, Cultured | 1995 |
Aspects of glutamine metabolism in human tumour cells.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Cell Division; Culture Media; Dose-Response Relationship, Drug; Glutamate-Ammonia Ligase; Glutamic Acid; Glutaminase; Glutamine; Humans; Male; Methionine Sulfoximine; Phosphates; Purines; Pyrimidines; Rats; Rats, Wistar; Thymidine; Tritium; Tumor Cells, Cultured | 1997 |
Cerebral seizure susceptibility and patterns of paroxysmal activity during embryonic development in the domestic chicken.
Topics: Animals; Anticonvulsants; Chick Embryo; Convulsants; Electroencephalography; Glutamic Acid; Methionine Sulfoximine; Ouabain; Pentylenetetrazole; Phenytoin; Seizures | 1973 |
An inhibitor of exported Mycobacterium tuberculosis glutamine synthetase selectively blocks the growth of pathogenic mycobacteria in axenic culture and in human monocytes: extracellular proteins as potential novel drug targets.
Topics: Aminobutyrates; Animals; Anti-Bacterial Agents; Cell Wall; Drug Synergism; Enzyme Inhibitors; Extracellular Space; Glutamate-Ammonia Ligase; Glutamic Acid; Humans; Methionine Sulfoximine; Monocytes; Mycobacterium tuberculosis; Peptidoglycan; Polyglutamic Acid; Sheep | 1999 |
Site-directed mutagenesis of Glu-297 from the alpha-polypeptide of Phaseolus vulgaris glutamine synthetase alters kinetic and structural properties and confers resistance to L-methionine sulfoximine.
Topics: Amino Acid Substitution; Binding Sites; Cloning, Molecular; Escherichia coli; Fabaceae; Genetic Complementation Test; Glutamate-Ammonia Ligase; Glutamic Acid; Kinetics; Methionine Sulfoximine; Mutagenesis, Site-Directed; Plants, Medicinal; Recombinant Fusion Proteins | 1999 |
Glutamine synthetase activity in Solanaceous cell suspensions accumulating alkaloids or not. 13C NMR and enzymatic assay.
Topics: Alkaloids; Cells, Cultured; Datura stramonium; Enzyme Induction; Enzyme Inhibitors; gamma-Aminobutyric Acid; Gene Expression Regulation, Plant; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Magnetic Resonance Spectroscopy; Methionine Sulfoximine; Nicotiana; Plant Proteins; Plants, Medicinal; Plants, Toxic; Species Specificity; Suspensions | 1999 |
Methionine sulfoximine shows excitotoxic actions in rat cortical slices.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Cerebral Cortex; Evoked Potentials; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; In Vitro Techniques; L-Lactate Dehydrogenase; Male; Methionine Sulfoximine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1999 |
Effect of acute exposure to ammonia on glutamate transport in glial cells isolated from the salamander retina.
Topics: Amino Acid Transport System X-AG; Ammonia; Animals; Anions; Aspartic Acid; ATP-Binding Cassette Transporters; Cell Separation; Glutamate-Ammonia Ligase; Glutamic Acid; Hydrogen-Ion Concentration; Ion Channel Gating; Membrane Potentials; Methionine Sulfoximine; Neuroglia; Patch-Clamp Techniques; Potassium; Quaternary Ammonium Compounds; Retina; Sodium; Urodela | 2001 |
Chronic inhibition of glutamine synthetase is not associated with impairment of learning and memory in mice.
Topics: Animals; Brain; Brain Chemistry; Glutamate-Ammonia Ligase; Glutamic Acid; Learning Disabilities; Maze Learning; Memory Disorders; Methionine Sulfoximine; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neurodegenerative Diseases; Neurons | 2002 |
Synergistic versus antagonistic actions of glutamate and glutathione: the role of excitotoxicity and oxidative stress in neuronal disease.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Flour; Glutamic Acid; Glutathione; Kynurenic Acid; L-Lactate Dehydrogenase; Male; Methionine Sulfoximine; Mice; Mice, Inbred Strains; N-Methylaspartate; Nervous System Diseases; Oxidative Stress; Plants, Toxic; Rats; Rats, Sprague-Dawley; Sitosterols | 2002 |
The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine.
Topics: Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Carrier Proteins; Cation Transport Proteins; DNA-Binding Proteins; Enzyme Inhibitors; Fungal Proteins; Gene Expression; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Intracellular Fluid; Methionine Sulfoximine; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Repressor Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Trans-Activators; Transcription Factors | 2002 |
Regulation of amino acid uptake in conifers by exogenous and endogenous nitrogen.
Topics: Adaptation, Physiological; Amino Acids; Aminooxyacetic Acid; Azaserine; Enzyme Inhibitors; Glutamate Synthase; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Methionine Sulfoximine; Nitrate Reductase; Nitrate Reductases; Nitrates; Nitrogen; Plant Roots; Quaternary Ammonium Compounds; Tracheophyta; Transaminases; Tungsten Compounds; Up-Regulation | 2002 |
Glutamine synthetase enhances the clearance of extracellular glutamate by the neural retina.
Topics: Animals; Chick Embryo; Enzyme Induction; Enzyme Inhibitors; Extracellular Space; Glutamate-Ammonia Ligase; Glutamic Acid; In Vitro Techniques; Methionine Sulfoximine; Neuroglia; Neurons; Retina; Sodium | 2002 |
Regional differences in glutamine synthetase inhibition by L-methionine sulfoximine: a microdialysis study in the rabbit brain.
Topics: Animals; Brain; Enzyme Inhibitors; Frontal Lobe; Glutamate-Ammonia Ligase; Glutamic Acid; Hippocampus; Male; Methionine Sulfoximine; Microdialysis; Rabbits | 2003 |
Glutamic acid and glutamine metabolism in cerebral cortex after seizures induced by methionine sulphoximine.
Topics: Cerebral Cortex; Glutamates; Glutamic Acid; Glutamine; Methionine; Methionine Sulfoximine; Seizures | 1959 |
N-terminal extension of canine glutamine synthetase created by splicing alters its enzymatic property.
Topics: Adenosine Triphosphate; Alternative Splicing; Animals; Blotting, Western; Chlorides; Chromatography, Gel; DNA Primers; Dogs; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Exons; Glutamate-Ammonia Ligase; Glutamic Acid; Green Fluorescent Proteins; Humans; Hydroxylamine; Ions; Kinetics; Luminescent Proteins; Metals; Methionine Sulfoximine; Mice; Protein Biosynthesis; Protein Conformation; Protein Isoforms; Protein Structure, Tertiary; Recombinant Proteins; RNA, Messenger; Spectrometry, Fluorescence; Tissue Distribution; Transcription, Genetic; Tryptophan | 2004 |
Effects of methionine sulfoximine on the glutamine and glutamate content and cell volume in rat cerebral cortical slices: involvement of mechanisms not related to inhibition of glutamine synthesis.
Topics: Acetates; Animals; Cell Size; Cerebral Cortex; Dose-Response Relationship, Drug; Glutamic Acid; Glutamine; In Vitro Techniques; Male; Methionine Sulfoximine; Rats; Rats, Wistar | 2004 |
Role of ammonia in reversal of glutamate-mediated Müller cell swelling in the rat retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Ammonia; Animals; Cell Death; Cell Size; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Hypothermia; Methionine Sulfoximine; Neurons; Rats; Rats, Sprague-Dawley; Retina; Retinal Diseases; Tissue Fixation | 2004 |
Glial regulation of nonsynaptic extracellular glutamate in the substantia nigra.
Topics: Animals; Calcium; Calcium Signaling; Citrates; Excitatory Amino Acid Agonists; Extracellular Fluid; Glutamic Acid; Glutamine; Homeostasis; Male; Membrane Potentials; Methionine Sulfoximine; Microdialysis; Neuroglia; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Substantia Nigra; Synaptic Transmission; Up-Regulation | 2005 |
Excitatory synaptic transmission persists independently of the glutamate-glutamine cycle.
Topics: Animals; Animals, Newborn; Cells, Cultured; Cerebral Cortex; Electric Stimulation; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; Glutamic Acid; Glutamine; Hippocampus; Methionine Sulfoximine; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Rats; Synapses; Synaptic Transmission | 2007 |
Exogenous ammonium inhibits petal pigmentation and expansion in Gerbera hybrida.
Topics: Anthocyanins; Asteraceae; Azaserine; Cells, Cultured; Flowers; Gene Expression Regulation, Plant; Genes, Plant; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Methionine Sulfoximine; Pigmentation; Quaternary Ammonium Compounds; Time Factors | 2008 |
Dual regulation of Ca2+-dependent glutamate release from astrocytes: vesicular glutamate transporters and cytosolic glutamate levels.
Topics: Animals; Astrocytes; Calcium; Cytosol; Extracellular Space; Glutamate-Ammonia Ligase; Glutamic Acid; Green Fluorescent Proteins; Immunohistochemistry; Methionine Sulfoximine; Physical Stimulation; Rats; Rats, Sprague-Dawley; RNA Interference; Transfection; Vesicular Glutamate Transport Protein 1; Vesicular Glutamate Transport Protein 2; Vesicular Glutamate Transport Proteins | 2009 |
Glutamate metabolic pathways and retinal function.
Topics: Animals; Aspartate Aminotransferases; Electroretinography; Enzyme Inhibitors; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Homeostasis; Immunohistochemistry; Ketoglutaric Acids; Lactic Acid; Methionine Sulfoximine; Photoreceptor Cells, Vertebrate; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Succinic Acid; Synaptic Transmission; Vision, Ocular | 2009 |
Methionine sulfoximine, an inhibitor of glutamine synthetase, lowers brain glutamine and glutamate in a mouse model of ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Biomarkers; Corpus Striatum; Disease Models, Animal; Down-Regulation; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Glutathione; Humans; Kaplan-Meier Estimate; Magnetic Resonance Spectroscopy; Methionine Sulfoximine; Mice; Mice, Transgenic; Motor Cortex; Neuroprotective Agents; Neurotoxins; Oxidative Stress; Superoxide Dismutase; Superoxide Dismutase-1; Treatment Outcome | 2010 |
Inhibition of glutamate/glutamine cycle in vivo results in decreased benzodiazepine binding and differentially regulated GABAergic subunit expression in the rat brain.
Topics: Animals; Autoradiography; Benzodiazepines; Binding Sites; Brain; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Male; Methionine Sulfoximine; Protein Binding; Protein Subunits; Rats; Rats, Wistar; Receptors, GABA; RNA, Messenger; Time Factors; Tritium | 2010 |
Methionine sulfoximine may improve inflammation in autism, a novel hypothesized treatment for autism.
Topics: Animals; Autistic Disorder; Excitatory Amino Acid Antagonists; Fatty Acids; Glutamic Acid; Humans; Inflammation; Methionine Sulfoximine | 2010 |
Cellular localization of glutamate and glutamine metabolism and transport pathways in the rat ciliary epithelium.
Topics: Animals; Aqueous Humor; Biological Transport; Carrier Proteins; Ciliary Body; Enzyme Inhibitors; Epithelial Cells; Fluorescent Antibody Technique, Indirect; Glutamate Plasma Membrane Transport Proteins; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Immunohistochemistry; Intravitreal Injections; Methionine Sulfoximine; Microscopy, Confocal; Pigment Epithelium of Eye; Rats; Rats, Sprague-Dawley | 2011 |
Downregulation of glutamine synthetase via GLAST suppression induces retinal axonal swelling in a rat ex vivo hydrostatic pressure model.
Topics: Animals; Aspartic Acid; Axons; Blotting, Western; Disease Models, Animal; Down-Regulation; Excitatory Amino Acid Transporter 1; Fluorescent Antibody Technique, Indirect; Glutamate-Ammonia Ligase; Glutamic Acid; Hydrostatic Pressure; Male; Methionine Sulfoximine; Rats; Rats, Sprague-Dawley; Retinal Degeneration; Retinal Ganglion Cells; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2011 |
Evidence for astrocytes as a potential source of the glutamate excess in temporal lobe epilepsy.
Topics: Animals; Astrocytes; Brain Waves; Disease Models, Animal; Electric Stimulation; Electroencephalography; Epilepsy, Temporal Lobe; Glutamic Acid; Hippocampus; Male; Methionine Sulfoximine; Microscopy, Immunoelectron; Rats; Rats, Sprague-Dawley | 2012 |
Chronic h1-antihistamine treatment increases seizure susceptibility after withdrawal by impairing glutamine synthetase.
Topics: Animals; Astrocytes; Blotting, Western; Chromatography, High Pressure Liquid; Convulsants; Electroshock; gamma-Aminobutyric Acid; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Histamine H1 Antagonists; Histidine Decarboxylase; Immunohistochemistry; Kindling, Neurologic; Male; Methionine Sulfoximine; Mice; Mice, Inbred C57BL; Mice, Knockout; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Substance Withdrawal Syndrome | 2012 |
Involvement of astroglial glutamate-glutamine shuttle in modulation of the jaw-opening reflex following infraorbital nerve injury.
Topics: Animals; Astrocytes; Constriction, Pathologic; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Glutamate-Ammonia Ligase; Glutamic Acid; Jaw; Male; Mandibular Nerve; Maxillary Nerve; Methionine Sulfoximine; Movement Disorders; Muscle, Skeletal; Rats, Sprague-Dawley; Reflex; Skin Physiological Phenomena; Trigeminal Motor Nucleus | 2014 |
Blockade of spinal glutamate recycling produces paradoxical antinociception in rats with orofacial inflammatory pain.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Astrocytes; Botulinum Toxins, Type A; Facial Pain; Freund's Adjuvant; Glutamate-Ammonia Ligase; Glutamic Acid; Hyperalgesia; Injections, Intraventricular; Interleukin-1beta; Male; Methionine Sulfoximine; Nociception; Rats; Spinal Cord Dorsal Horn | 2015 |
The Molecular Basis of TnrA Control by Glutamine Synthetase in Bacillus subtilis.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Bacillus subtilis; Bacterial Proteins; Binding Sites; Binding, Competitive; Enzyme Stability; Gene Deletion; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Kinetics; Ligands; Methionine Sulfoximine; Models, Molecular; Molecular Weight; Promoter Regions, Genetic; Protein Conformation; Recombinant Proteins; Repressor Proteins; Surface Plasmon Resonance | 2016 |
Specificity of exogenous acetate and glutamate as astrocyte substrates examined in acute brain slices from female mice using methionine sulfoximine (MSO) to inhibit glutamine synthesis.
Topics: Acetates; Animals; Astrocytes; Brain; Carbon Isotopes; Female; Glutamic Acid; Glutamine; Methionine Sulfoximine; Mice; Organ Culture Techniques; Substrate Specificity | 2017 |
Glutamine: a major player in nitrogen catabolite repression in the yeast Dekkera bruxellensis.
Topics: Ammonium Compounds; Catabolite Repression; Dekkera; Gene Expression Regulation, Fungal; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Industrial Microbiology; Methionine Sulfoximine; Nitrates; Nitrogen; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Regulon | 2017 |
Insufficient glutamine synthetase activity during synaptogenesis causes spatial memory impairment in adult mice.
Topics: Animals; Animals, Newborn; Astrocytes; Behavior Observation Techniques; Behavior, Animal; CA3 Region, Hippocampal; Glial Fibrillary Acidic Protein; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Male; Methionine Sulfoximine; Mice; Models, Animal; Neurogenesis; Neurons; Spatial Memory; Synaptic Transmission | 2019 |
Pretreatment with a glutamine synthetase inhibitor MSO delays the onset of initial seizures induced by pilocarpine in juvenile rats.
Topics: Animals; Brain; Disease Models, Animal; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Male; Methionine Sulfoximine; Pilocarpine; Rats, Sprague-Dawley; Seizures | 2021 |
Inhibition of Glutamate Release, but Not of Glutamine Recycling to Glutamate, Is Involved in Delaying the Onset of Initial Lithium-Pilocarpine-Induced Seizures in Young Rats by a Non-Convulsive MSO Dose.
Topics: Animals; Brain; Disease Progression; Dose-Response Relationship, Drug; Glutamic Acid; Glutamine; Lithium; Male; Methionine Sulfoximine; Pilocarpine; Rats; Rats, Sprague-Dawley; Secretory Pathway; Seizures | 2021 |