glutamic acid has been researched along with ketamine in 251 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (2.39) | 18.7374 |
| 1990's | 40 (15.94) | 18.2507 |
| 2000's | 59 (23.51) | 29.6817 |
| 2010's | 105 (41.83) | 24.3611 |
| 2020's | 41 (16.33) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chéramy, A; Desmonts, JM; Glowinski, J; Mantz, J; Thierry, AM | 1 |
| Henry, JL; Hong, YG | 1 |
| Macdonald, AG; Ramsey, RL; Shelton, CJ; Usherwood, PN | 1 |
| Bradford, HF; Coutinho-Netto, J; Dias, JJ; Lachat, JJ; Louzada-Júnior, P; Santos, WF | 1 |
| Ivanova, SF; Sanzharovskiĭ, AV; Storozhuk, VM | 1 |
| Zhang, LH; Zhang, SS | 1 |
| Harada, K; Kemmotsu, O; Okamura, A; Yamamura, T | 1 |
| Keilhoff, G; Schmidt, W; Stastný, F; Wolf, G | 1 |
| Hestrin, S; Nicoll, RA; Sah, P | 1 |
| Heinemann, U; Mudrick, LA | 1 |
| Login, IS | 1 |
| Catalin, D; Cherkaoui, N; Jean, A; Kessler, JP | 1 |
| Piñón, R | 1 |
| MacDonald, JF; Miljkovic, Z; Pennefather, P | 1 |
| Ashford, ML; Boden, P; Ramsey, RL; Usherwood, PN | 1 |
| Chan, PH; Chu, L | 1 |
| Harrison, NL; Simmonds, MA | 1 |
| Guyenet, PG; Raja, SN | 1 |
| Cullen, KD; Martin, RJ | 1 |
| Gombar, KK; Kaur, AH; Khosla, P; Srivastava, RK | 1 |
| Hosono, T; Kanosue, K; Yanase-Fujiwara, M; Zhang, YH | 1 |
| Henry, JL; Radhakrishnan, V | 1 |
| Lambert, DG; Nicol, B; Rowbotham, DJ | 1 |
| Gonzales, JM; Irvine, S; Loeb, AL; Reichard, PS | 1 |
| D'Hooge, R; De Deyn, PP; Pei, YQ | 1 |
| Durand, J | 1 |
| Bousquet, P; Feldman, J; Mettauer, B; Monassier, L; Roegel, JC; Tibiriça, E | 1 |
| Arustei, V; Cuparencu, B; de Novellis, V; Falciani, M; Filippelli, A; Rossi, F; Safta, L | 1 |
| Peng, L; Zhao, Z | 1 |
| Koffel, B; Lahti, AC; LaPorte, D; Tamminga, CA | 1 |
| Georgieff, M; Himmelseher, S; Pfenninger, E | 1 |
| Gao, XM; Holcomb, HH; Lahti, AC; Tamminga, CA | 1 |
| Adams, B; Daly, D; Moghaddam, B; Verma, A | 1 |
| Berman, FW; Murray, TF | 1 |
| Gupta, MC; Singh, J | 1 |
| Arai, T; Kataoka, K; Miyazaki, H; Nakamura, Y | 1 |
| Brodie, JD; Cancro, R; Cooper, T; Dewey, SL; Hurley, A; Logan, J; Schloesser, R; Simkowitz, P; Smith, GS; Vitkun, SA; Volkow, ND | 1 |
| Kitamura, R; Miyawaki, I; Mori, K; Nakamura, K; Yokubol, B | 1 |
| Ninomiya, T; Omote, K; Yamauchi, M | 1 |
| Alfonso, M; Arufe, MC; Durán, R | 1 |
| Vollenweider, FX | 1 |
| Jevtovic-Todorovic, V; Mennerick, S; Olney, JW; Shen, W; Todorovic, SM; Zorumski, CF | 1 |
| Budd, SL; Castilho, RF; Hansson, O; Nicholls, DG; Ward, MW | 1 |
| Besson, JM; Montagne-Clavel, J; Rivot, JP; Sousa, A | 1 |
| Avgovstides-Savvopoulou, P; Guiba-Tziampiri, O; Karkavelas, G; Loizidis, T; Soubasi, V; Spandou, E | 1 |
| Tamminga, C | 1 |
| Anand, A; Berman, RM; Cappiello, A; Charney, DS; Heninger, GR; Krystal, JH; Oren, DA | 1 |
| Buggy, DJ; Lambert, DG; Nicol, B; Rowbotham, DJ | 1 |
| Auchter, M; Himmelseher, S; Kochs, E; Pfenninger, E | 1 |
| Suman, P; Talwar, A; Tandon, OP | 1 |
| Amaha, K; Sakai, F | 1 |
| Albrecht, J; Hesselink, M; Hilgier, W; Januszewski, S; Quack, G; Zielińska, M | 1 |
| Kryzhanovskii, GN; Kucheryanu, VG | 1 |
| Brunson, KL; Cohen, RW; Cromwell, HC; Khanna, A | 1 |
| Durieux, ME; Hoenemann, CW; Hollmann, MW; Liu, HT; Liu, WH | 2 |
| Angrist, B; Chakravorty, S; Chappell, PB; Duncan, EJ; Efferen, TR; Gonzenbach, S; Ko, GN; Madonick, SH; Parwani, A; Rajan, R; Rotrosen, JP; Stephanides, M; Szilagyi, S | 1 |
| Brodin, E; Lindefors, N; Radu, D; Weber, G | 1 |
| Andresen, MC; Evans, C; Irnaten, M; K Chang, KS; Mendelowitz, D; Venkatesan, P; Wang, J | 1 |
| Shim, SS | 1 |
| Fujimura, N; Kawamata, M; Kawamata, Y; Namiki, A; Narimatsu, E | 1 |
| Kalkman, HO | 1 |
| Eckeli, AL; Gabilan, NH; Gondran, M; Migues, PV; Rodrigues, AL | 1 |
| Liu, CY; Liu, JZ; Xie, YF | 2 |
| Anderson, JJ; Baccei, CS; Bristow, LJ; Lorrain, DS; Varney, MA | 1 |
| Anderson, JJ; Baccei, CS; Bristow, LJ; Campbell, UC; Correa, LD; Lorrain, DS; Pinkerton, AB; Rodriguez, DE; Rowe, B; Schaffhauser, H; Varney, MA; Vernier, JM | 1 |
| Belger, A; D'Souza, DC; Hoffman, R; Krystal, JH; Mathalon, D; Perry, E | 1 |
| Fang, H; Huang, Y; Lim, YJ; Zuo, Z | 1 |
| Carley, DW; Radulovacki, M; Saponjic, J | 2 |
| Peña, C; Reinés, A; Rodríguez de Lores Arnaiz, G | 1 |
| Alonso, TJ; Castro Fuentes, R; García Dopico, J; González Hernández, T; Perdomo Díaz, J; Rodríguez Díaz, M | 1 |
| Liu, CY; Liu, FY; Liu, JZ; Xie, DP | 1 |
| Garcia, R; Hunt, MJ; Kessal, K | 1 |
| Askalany, AR; Baba, H; Kohno, T; Petrenko, AB; Sakimura, K; Yamakura, T | 1 |
| Aalto, S; Gustafsson, LL; Hietala, J; Hirvonen, J; Ihalainen, J; Kajander, J; Någren, K; Scheinin, H; Syvälahti, E; Tanila, H; Vilkman, H | 1 |
| Inomata, S; Kakiuchi, Y; Kohda, Y; Miyabe, M; Ohara, Y; Osaka, Y; Sukegawa, I; Toyooka, H | 1 |
| Arendt-Nielsen, L; Cairns, BE; Castrillon, E; Hupfeld, S; Sessle, BJ; Svensson, P; Wang, K | 1 |
| Do, SH; Kim, HK; Kim, JH; Lim, YJ; Yun, JY; Zuo, Z | 1 |
| Garcia, R; Léna, I; Razoux, F | 1 |
| Bar, G; Ebstein, RP; Ermilov, M; Heresco-Levy, U; Javitt, DC; Levin, R | 1 |
| Howland, RH | 1 |
| Ambesi-Impiombato, A; de Bartolomeis, A; Iasevoli, F; Muscettola, G; Polese, D | 1 |
| Assis, MA; Fonteles, MM; Freitas, RL; Freitas, RM; Pereira, MB; Silva, RF; Takahashi, RN | 1 |
| Ali, YM; Cheng, RK; Meck, WH | 1 |
| Corlett, PR; Fletcher, PC; Honey, GD | 1 |
| Cilia, J; Hatcher, P; Jones, DN; Reavill, C | 1 |
| Arendt-Nielsen, L; Cairns, BE; Castrillon, EE; Ernberg, M; Sessle, BJ; Svensson, P; Wang, K | 1 |
| Floresco, SB; Ghods-Sharifi, S; Tse, MT | 1 |
| Galdi, S; Hemmings, HC; Hendrick, JP; Snyder, GL | 1 |
| Deakin, JF; Dursun, SM; Hallak, JE; Lees, J; McKie, S; Williams, SR | 1 |
| Bouhassira, D; Kern, D; Luce, V; Pelle-Lancien, E | 1 |
| Hang, YN; Jing, W; Wang, L | 1 |
| Anand, R; Bernstein, HG; Braunewell, KH; Gierke, P; Heinemann, U; Noack, C; Zhao, C | 1 |
| Cruz, SL; López-Rubalcava, C; Páez-Martinez, N; Soberanes-Chávez, P | 1 |
| Biedermann, F; Fleischhacker, WW | 1 |
| Gilling, KE; Hechenberger, M; Jatzke, C; Parsons, CG | 1 |
| Machado-Vieira, R; Manji, HK; Zarate, CA | 1 |
| Hashimoto, K | 1 |
| Arancio, O; Balsam, P; Chuhma, N; Conjard-Duplany, A; Fairhurst, S; Gaisler-Salomon, I; Galloway, MP; Ghoddoussi, F; Hen, R; Lee, S; Lewandowski, N; Masson, J; Miller, GM; Moore, HM; Rayport, S; Small, SA; Wang, Y; Zhang, H | 1 |
| Armelloni, S; Berra, S; Carraro, M; Corbelli, A; Giardino, L; Guerrot, D; Ikehata, M; Li, M; Mattinzoli, D; Messa, P; Rastaldi, MP; Tourrel, F; Zennaro, C | 1 |
| Stone, JM | 1 |
| Gołembiowska, K; Nikiforuk, A; Popik, P | 1 |
| Tyurin, NL | 1 |
| Cui, S; Gu, X; Liu, Y; Ma, Z; Wu, X | 1 |
| Alstergren, P; Ernberg, M; Hajati, AK; Kopp, S; Nilsson, M; Sessle, BJ | 1 |
| Javitt, DC | 1 |
| Colaianna, M; Cuomo, V; Dubois-Dauphin, M; Jaquet, V; Krause, KH; Schiavone, S; Sorce, S; Trabace, L; Tucci, P | 1 |
| Parada, CA; Rondon, ES; Valadão, CA; Vieira, AS | 1 |
| Deuschle, M; Gass, P; Paslakis, G | 1 |
| Charney, DS; Murrough, JW | 1 |
| Fasula, M; Gomez, R; Krystal, JH; Mason, GF; Pittman, B; Sanacora, G; Valentine, GW; Watzl, J | 1 |
| Chourasia, TK; Joy, KP; Krishnamurthy, S; Kumar, A; Reddy, NR | 1 |
| Bang, E; Choe, BY; Choi, CB; Hong, KS; Kim, HJ; Kim, SY; Lee, C; Lee, DW; Lee, H; Lee, SH; Woo, DC | 1 |
| Cowen, PJ; Mhuircheartaigh, RN; Taylor, MJ; Tiangga, ER | 1 |
| Cardenas, R; Quintero, L; Suarez-Roca, H | 1 |
| Adell, A; Jiménez-Sánchez, L; López-Gil, X; Romón, T | 1 |
| Baumann, J; Drevets, WC; Ibrahim, LA; Luckenbaugh, DA; Machado-Vieira, R; Marenco, S; Salvadore, G; Shen, J; van der Veen, JW; Zarate, CA; Zhang, Y | 1 |
| Behar, KL; Cho, W; Chowdhury, GM; Rothman, DL; Sanacora, G; Thomas, MA | 1 |
| Barker, GJ; De Simoni, S; Dietrich, C; Edden, R; Krystal, JH; Mehta, MA; Nutt, D; Reed, LJ; Stone, JM | 1 |
| Brunt, TM; McMaster, MT; Niesink, RJ; van Amsterdam, JG | 1 |
| Henter, ID; Mathews, DC; Zarate, CA | 1 |
| Krystal, JH; Moghaddam, B | 1 |
| Balu, D; Basu, A; Benneyworth, M; Coyle, JT; Konopaske, G | 1 |
| Arora, S; Kaur, T; Pundir, M; Singh, AP; Singh, R | 1 |
| Salvadore, G; Singh, JB | 1 |
| Asllani, I; Chaudhury, NH; Corcoran, CM; Inbar, BP; Khan, UA; Lieberman, JA; Moore, H; Paniagua, B; Schobel, SA; Small, SA; Styner, MA | 1 |
| Autry, AE; Kavalali, ET; Monteggia, LM; Nosyreva, E; Ryazanov, AG; Szabla, K | 1 |
| Auer, DP; Fone, KC; Napolitano, A; Porkess, V; Schubert, MI; Shah, K | 1 |
| Duman, RS; Krystal, JH; Sanacora, G | 2 |
| Fam, J; Furby, H; Howes, OD; Hughes, E; Morgan, C; Pepper, F; Stone, JM | 1 |
| Flight, MH | 1 |
| Aghajanian, GK; Duman, RS | 1 |
| Ionescu, DF; Niciu, MJ; Richards, EM; Zarate, CA | 1 |
| Brady, LS; Potter, WZ | 1 |
| Liu, XY; Qiu, LL; Sun, HL; Wang, N; Wang, XM; Yang, C; Yang, JJ; Zhang, GF | 1 |
| Alvarsson, A; Branzell, N; Sousa, VC; Stan, TL; Svenningsson, P | 1 |
| Aligny, C; Do-Rego, JC; Dourmap, N; Gonzalez, BJ; Jégou, S; Leroux, P; Leroux-Nicollet, I; Marret, S; Ramdani, Y; Roux, C | 1 |
| Adams, RA; Blockeel, AJ; Friston, KJ; Jones, MW; Moran, RJ; Stephan, KE | 1 |
| Sanacora, G; Schatzberg, AF | 1 |
| Delpire, E; Hall, BJ; Hargroder, EA; Miller, OH; Wang, CC; Yang, L; Zhang, Y | 1 |
| Abdallah, CG; Duman, RS; Krystal, JH; Sanacora, G | 2 |
| Cloke, JM; Winters, BD | 1 |
| Deakin, JFW; Dutta, A; McKie, S | 1 |
| Reardon, S | 1 |
| Franceschelli, A; Herchick, S; Pitychoutis, PM; Sens, J; Thelen, C | 1 |
| Erisir, A; Ito, W; Morozov, A | 1 |
| DeBold, JF; Holly, EN; Hwa, LS; Miczek, KA; Nathanson, AJ; Newman, EL; Shimamoto, A; Tayeh, JK; Wilens, AR | 1 |
| Fujino, Y; Kamibayashi, T; Kosaka, J; Morita, T; Shibuta, S | 1 |
| Bundscherer, A; Friedrich, O; Graf, BM; Lindner, R; Sinner, B | 1 |
| Brandon, NJ; Brown, JT; Dawson, N; Dunlop, J; Hedde, JR; Hughes, ZA; Kurihara, M; McVie, A; Morris, BJ; Pratt, JA; Randall, AD; Seymour, PA; Shen, S; Thomson, DM; Winchester, CL | 1 |
| Dalla, C; Ferreira, C; Kokras, N; Melo, A; Pêgo, JM; Sousa, N; Ventura-Silva, AP | 1 |
| Flood, P; Hunter, L; Kegeles, LS; Levinson, A; Mao, X; Milak, MS; Moore, H; Ogden, RT; Rodriguez, CI; Shungu, DC; Simpson, HB; Vermes, D; Xie, S | 1 |
| Deep-Soboslay, A; Gray, AL; Hyde, TM; Kleinman, JE; Sodhi, MS | 1 |
| Hall, BJ; Miller, OH; Moran, JT | 1 |
| de Simoni, S; Doyle, O; Mehta, MA; Schwarz, AJ; Shcherbinin, S; Zelaya, FO | 1 |
| Cooper, TB; Kegeles, LS; Keilp, JG; Mann, JJ; Mao, X; Milak, MS; Mulhern, ST; Ogden, RT; Oquendo, MA; Parter, AL; Proper, CJ; Rodriguez, CI; Shungu, DC; Suckow, RF | 1 |
| Chen, MH; Hong, CJ; Li, CT; Lin, WC; Liu, RS; Su, TP; Tu, PC; Yang, BH | 1 |
| Duman, RS; Gerhard, DM; Wohleb, ES | 1 |
| Fuchs, T; Jefferson, SJ; Luscher, B; Pribiag, H; Ren, Z; Shorey, M; Stellwagen, D | 1 |
| Banasr, M; Behar, KL; Bristow, L; Chowdhury, GM; Duman, RS; Ma, X; Pittman, B; Rothman, DL; Sanacora, G; Schaeffer, E; Thomas, M; Zhang, J | 1 |
| Grace, AA; Pogarell, O; Qi, Z; Tretter, F; Voit, EO; Yu, GP | 1 |
| du Jardin, KG; Elfving, B; Müller, HK; Sanchez, C; Wegener, G | 1 |
| Mauch, J; Pandit, R; Pitychoutis, PM; Sens, J; Thelen, C | 1 |
| Pałucha-Poniewiera, A; Pilc, A | 1 |
| Ballard, ED; Lener, MS; Niciu, MJ; Nugent, AC; Park, LT; Park, M; Zarate, CA | 1 |
| Barton-McArdle, A; Bolding, MS; Frölich, MA; Kraguljac, NV; Lahti, AC; Nichols, N; Reid, MA; Tran, S; White, DM | 1 |
| Colic, L; Demenescu, LR; Fejtova, A; Heinze, HJ; Li, M; Metzger, CD; Salvadore, G; Speck, O; Steiner, J; Walter, M | 1 |
| Aizenman, E; Brueckner, F; Chen, W; Chiavacci, R; Elsen, G; Falk, MJ; Hakonarson, H; Hedrich, UB; Hörtnagel, K; Hu, C; Kosobucki, GJ; Kusumoto, H; Lemke, JR; Li, D; Marsh, ED; McCormick, EM; Naase, C; Ortiz-Gonzalez, XR; Schulien, AJ; Tankovic, A; Tian, L; Traynelis, SF; von Stülpnagel-Steinbeis, C; Yuan, H | 1 |
| Bottrel, N; Corum, DG; Drevets, WC; Fiehn, O; Kaddurah-Daouk, R; Motsinger-Reif, A; Rotroff, DM; Salvadore, G; Singh, J | 1 |
| Caffino, L; Chiamulera, C; Di Chio, M; Fumagalli, F; Giannotti, G; Mottarlini, F; Piva, A; Venniro, M; Yew, DT | 1 |
| Bonnet, U | 1 |
| Kantrowitz, JT; Mann, JJ; Mao, X; Milak, MS; Shungu, DC | 1 |
| Janardhanan, A; Sadanand, A; Vanisree, AJ | 1 |
| Abdallah, CG; Coplan, JD; Gupta, S; Jackowski, A; Mao, X; Mathew, SJ; Salas, R; Sato, JR; Shungu, DC | 1 |
| Abdallah, CG; Mathew, SJ; Murrough, JW | 1 |
| Abdallah, CG; Carson, RE; DellaGioia, N; DeLorenzo, C; Esterlis, I; Krystal, JH; Matuskey, D; Nabulsi, N; Parsey, RV; Pietrzak, RH; Pittenger, C; Sanacora, G; Yang, J | 1 |
| Featherstone, R; Lin, R; Mensah-Brown, K; Mihara, T; Siegel, SJ; Sobota, R | 1 |
| Hondebrink, L; Kasteel, EEJ; Tukker, AM; Verboven, AHA; Westerink, RHS; Wijnolts, FMJ | 1 |
| Andreou, C; Curic, S; Eichler, I; Eichler, L; Gallinat, J; Hanganu-Opatz, I; Leicht, G; Mulert, C; Polomac, N; Steinmann, S; Thiebes, S; Zöllner, C | 1 |
| Fu, B; Fu, X; Liu, C; Yu, T; Zhang, L; Zhang, Y | 1 |
| Chan, AW; LeDue, J; McGirr, A; Murphy, TH; Xie, Y | 1 |
| Nasirinezhad, F; Saffarpour, S | 1 |
| Carlson, M; Carter, CS; Choo, TH; Corlett, PR; Girgis, RR; Grinband, J; Javitt, DC; Kantrowitz, JT; Kegeles, LS; Krystal, JH; Lesh, TA; Lieberman, JA; Maddock, RJ; Mason, G; Potter, WZ; Qiu, M; Ragland, JD; Robinson, J; Rothman, DL; Tanase, C; Wall, MM | 1 |
| Cuoco, JA; Hadjiargyrou, M; Hitscherich, K; Hoehmann, CL; Leheste, JR; Pavia, C; Torres, G | 1 |
| Armessen, C; Ayache, SS; Lefaucheur, JP; Locko, B; Sorel, M; Zrek, N | 1 |
| Gilbert, JR; Nugent, AC; Wills, KE; Yarrington, JS; Zarate, CA | 1 |
| Cui, J; Li, Z; Liu, Y; Liu, Z; Wu, Y; Zhou, X; Zuo, D | 1 |
| Aoki, J; Cheng, H; Distler, U; Endle, H; Geisslinger, G; Hauser, MJ; Horta, G; Kirischuk, S; Laube, G; Luhmann, HJ; Morris, AJ; Nitsch, R; Qiao, L; Radyushkin, K; Röper, J; Sigurdsson, T; Tegeder, I; Tenzer, S; Thalman, C; Vogt, J | 1 |
| An, L; Banerjee, D; Evans, JW; Lally, N; Li, N; Nugent, AC; Roiser, JP; Shen, J; Snider, SL; Zarate, CA | 1 |
| Chen, GD; Chou, D; Ho, YC; Hsieh, MC; Lai, CY; Lee, AS; Lin, TB; Peng, HY; Wang, HH; Wen, YC; Yang, PS | 1 |
| Constantino, LC; Costa, AP; Dal-Cim, T; de Oliveira, KA; de Oliveira, LF; Ludka, FK; Martins, WC; Pereira, FC; Poluceno, GG; Prediger, RD; Sampaio, TB; Tasca, CI | 1 |
| Pałucha-Poniewiera, A | 1 |
| Cubała, WJ; Gałuszko-Węgielnik, M; Górska, N; Słupski, J; Wiglusz, MS | 1 |
| Cui, W; Hong, W; Li, MD; Liu, Z; Ning, Y; Wang, J | 1 |
| Bianchi, M; Colic, L; Kretzschmar, M; Li, M; Liebe, T; McDonnell, C; Schott, BH; Speck, O; Walter, M; Woelfer, M | 1 |
| Biswal, BB; Chang, C; Colic, L; Fejtova, A; Heinze, HJ; Li, M; Mayberg, HS; Safron, A; Salvadore, G; Speck, O; Walter, M; Woelfer, M | 1 |
| Duan, XX; Feng, JG; Li, M; Liu, L; Liu, X; Wan, YQ; Wang, MZ; Wang, XB; Zhang, CX | 1 |
| Ajao, A; Ayeni, OJ; Ogundeji, MO; Onaolapo, AY; Onaolapo, OJ; Owolabi, AR | 1 |
| Flaherty, E; Mohamed, S; Pitychoutis, PM; Saurine, J; Sens, J; Thelen, C | 1 |
| Brockway, DF; Crowley, NA; Dao, NC; Feng, M; Jefferson, SJ; Luscher, B; Magee, SN; Morris, CJ | 1 |
| Andreou, C; Curic, S; Eichler, IC; Eichler, L; Gallinat, J; Leicht, G; Mulert, C; Polomac, N; Steinmann, S; Thiebes, S; Zöllner, C | 1 |
| Gardier, AM; Pham, TH | 1 |
| Bellomo, A; Berardis, DD; Carano, A; Fiengo, ALC; Fornaro, M; Giannantonio, MD; Kim, YK; Martinotti, G; Montemitro, C; Nicola, MD; Orsolini, L; Perna, G; Pompili, M; Santone, C; Serafini, G; Tomasetti, C; Valchera, A; Vellante, F; Ventriglio, A | 1 |
| Naldan, ME; Taghizadehghalehjoughi, A | 1 |
| Duman, RS; Fogaça, MV; Hare, B; Shinohara, R | 1 |
| Albuquerque, EX; Aracava, Y; Fischell, J; Gould, TD; Pereira, EFR; Riggs, LM; Thompson, SM; Zanos, P | 1 |
| Adell, A; Campa, L; Castro, E; Frago, C; Jiménez-Sánchez, L; López-Gil, X | 1 |
| Bryant, JE; Frölich, M; Kraguljac, NV; Lahti, AC; Reid, MA; Tran, S | 1 |
| Egerton, A | 1 |
| De Berardis, D; Di Giannantonio, M; Fornaro, M; Fraticelli, S; Kim, YK; Martinotti, G; Orsolini, L; Perna, G; Pompili, M; Serafini, G; Tomasetti, C; Valchera, A; Vellante, F; Volpe, U | 1 |
| Bustamante, J; Czerniczyniec, A; Karadayian, AG; Lores-Arnaiz, S | 1 |
| Armant, RJ; Bolaños-Guzmán, CA; Kokane, SS; Perrotti, LI | 1 |
| Bouças, AP; Can, AT; Dutton, M; Hermens, DF; Lagopoulos, J; Lilley, C; Simcock, G | 1 |
| Marek, GJ; Salek, AA | 1 |
| McCool, BA; McGinnis, MM; Parrish, BC | 1 |
| Fan, YY; Sun, LH; Wang, X; Zheng, HB | 1 |
| Davoudian, PA; Wilkinson, ST | 1 |
| Cooper, TB; Dong, Z; Grunebaum, MF; Kegeles, LS; Keilp, JG; Lin, X; Mann, JJ; Mao, X; Milak, MS; Mulhern, ST; Ogden, RT; Rashid, R; Shungu, DC; Suckow, RF | 1 |
| Frizzo, ME; Ohno, Y | 1 |
| Andrade, YCP; Batista, LA; Del Bel, EA; Fanelli, C; Issy, AC; Liégeois, JF; Minaldi, E; Moreira, FA; Rodrigues, LCM; Ropke, J; Viana, TG | 1 |
| Anastasio, NC; Cunningham, KA; Davis-Reyes, BD; Smith, AE; Xu, J; Zhou, J | 1 |
| Dumrongprechachan, V; Hamilton, P; Kozorovitskiy, Y; Minkowicz, S; Wu, M | 1 |
| Coombes, BJ; Frye, MA; Geske, JR; Lanza, IR; Morgan, RJ; Port, JD; Singh, B; Voort, JLV | 1 |
| Li, YF; Li, ZH; Liu, WG; Ran, YH; Wang, YH; Yao, JQ; Yin, YY; Yuan, J; Zhang, LM | 1 |
| Kwan, AC; Savalia, NK; Wu, H | 1 |
| Melonakos, ED; Nehs, CJ; Nikolaeva, KK; O'Brien, C; Rey, C; Siegmann, MJ; Solt, K | 1 |
| Du, D; Guo, F; Lin, H; Luo, C; Lv, S; Ye, F; Zhang, T; Zhang, Y; Zhou, L; Zhu, S | 1 |
| Flais, I; Lazarevic, V; Svenningsson, P; Yang, Y | 1 |
| Aleksandrova, LR; Phillips, AG | 1 |
| Zarate, CA | 1 |
| Himmerich, H; Juruena, MF; Kan, C; Keeler, JL; Treasure, J | 1 |
| Gärtner, M; Grimm, S; Henning, A; Lehmann, M; Scheidegger, M; Weigand, A; Wunder, A; Wyss, PO | 1 |
| Gould, TD; Riggs, LM; Thompson, SM | 1 |
| Camargo, A; Rodrigues, ALS | 1 |
| Aust, S; Bajbouj, M; Gärtner, M; Grimm, S; Henning, A; Herrera-Melendez, A; Scheidegger, M; Seifritz, E; Stippl, A; Weigand, A; Wyss, PO | 1 |
| Conway, CR; Hsu, FF; Izumi, Y; Mennerick, SJ; Nagele, P; Zorumski, CF | 1 |
| Belloch, FB; Cortés-Erice, M; Díaz-Perdigon, T; Herzog, E; Puerta, E; Tordera, RM; Zhang, XM | 1 |
| Alvarez, JC; Choucha, W; Colle, R; Corruble, E; David, DJ; Defaix, C; Etting, I; Gardier, AM; Mendez-David, I; Nguyen, TML; Tritschler, L | 1 |
| Bustillo, JR; Kruse, AO | 1 |
| Lv, S; Yao, K; Zhang, Y; Zhu, S | 1 |
| Arbelo, N; García-Rizo, C; Gassó, P; Gómez, M; Madero, S; Martínez-Pinteño, A; Mas, S; Morén, C; Parellada, E; Rodríguez, N; Treder, N | 1 |
| Beckmann, C; Carstens, L; Gärtner, M; Grimm, S; Hertrampf, R; Keicher, C; Meiering, MS; Mennes, M; Weigand, A; Weigner, D; Wunder, A | 1 |
| Curic, S; Haaf, M; Leicht, G; Mulert, C; Rauh, J; Steinmann, S | 1 |
| Chand, T; Colic, L; Danyeli, LV; Gensberger-Reigl, S; Götting, F; Jollant, F; Kretzschmar, M; Kurzweil, L; Li, M; Liebe, T; Macharadze, T; Munk, MHJ; Opel, N; Refisch, A; Sen, ZD; Speck, O; Wagner, G; Walter, M | 1 |
| Altê, GA; Camargo, A; Dalmagro, AP; Rodrigues, ALS; Tasca, CI; Zeni, ALB | 1 |
| Gardier, AM; Guilloux, JP; Nguyen, TML | 1 |
48 review(s) available for glutamic acid and ketamine
| Article | Year |
|---|---|
Advances and pathophysiological models of hallucinogenic drug actions in humans: a preamble to schizophrenia research.
Topics: Anesthetics, Dissociative; Brain; Consciousness; Dopamine; Glutamic Acid; Hallucinogens; Humans; Ketamine; Lysergic Acid Diethylamide; Psilocybin; Serotonin | 1998 |
Glutamatergic aspects of schizophrenia.
Topics: Cerebrovascular Circulation; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Ketamine; Neurotransmitter Agents; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Tomography, Emission-Computed | 1999 |
Antischizophrenic activity independent of dopamine D2 blockade.
Topics: Amino Acid Transport System X-AG; Animals; Antipsychotic Agents; Brain Chemistry; Dopamine D2 Receptor Antagonists; Drug Design; Drug Evaluation, Preclinical; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Frontal Lobe; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Humans; Interneurons; Ketamine; Lamotrigine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Receptor, Metabotropic Glutamate 5; Receptors, AMPA; Receptors, GABA; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Schizophrenia; Symporters; Triazines | 2002 |
NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development.
Topics: Animals; Antipsychotic Agents; Cerebral Cortex; Cognition; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Ketamine; Models, Neurological; Neural Pathways; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2003 |
Glutamate-modulating drugs & the treatment of mental disorders.
Topics: Acamprosate; Amantadine; Cycloserine; Glutamic Acid; Humans; Ketamine; Lamotrigine; Memantine; Mental Disorders; Psychotropic Drugs; Riluzole; Taurine; Triazines | 2007 |
From prediction error to psychosis: ketamine as a pharmacological model of delusions.
Topics: Animals; Association Learning; Delusions; Dopamine; Excitatory Amino Acid Antagonists; Glutamic Acid; Hallucinogens; Humans; Ketamine; Mental Processes; Models, Psychological; Synaptic Transmission | 2007 |
Antipsychotics in the early stage of development.
Topics: Antipsychotic Agents; Dopamine; Glutamic Acid; Humans; Ketamine; Phencyclidine; Receptors, Cholinergic; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Receptors, Serotonin; Schizophrenia; Serotonin; Severity of Illness Index; Synaptic Transmission | 2009 |
The role of the tripartite glutamatergic synapse in the pathophysiology and therapeutics of mood disorders.
Topics: Animals; Brain; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Ketamine; Mood Disorders; Neuroglia; Receptors, Glutamate; Riluzole; Synapses | 2009 |
Emerging role of glutamate in the pathophysiology of major depressive disorder.
Topics: Brain; Depressive Disorder, Major; Glutamic Acid; Humans; Ketamine; Memantine; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2009 |
Imaging the glutamate system in humans: relevance to drug discovery for schizophrenia.
Topics: Brain; Drug Delivery Systems; Drug Discovery; Glutamic Acid; Humans; Ketamine; Magnetic Resonance Spectroscopy; Models, Neurological; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Tomography, Emission-Computed, Single-Photon | 2009 |
Glutamatergic theories of schizophrenia.
Topics: Animals; Brain; Dopamine; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Ketamine; Nerve Net; Phencyclidine; Prefrontal Cortex; Psychological Theory; Receptors, Dopamine D2; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Schizophrenic Psychology; Synaptic Transmission | 2010 |
[The role of the glutamatergic system in pathophysiology and pharmacotherapy for depression: preclinical and clinical data].
Topics: Animals; Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Ketamine; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Riluzole; Stress, Psychological | 2011 |
Possible long-term effects of γ-hydroxybutyric acid (GHB) due to neurotoxicity and overdose.
Topics: Alcoholism; Anesthetics; Anesthetics, Dissociative; Animals; Central Nervous System Depressants; Cognition Disorders; Coma; Drug Overdose; Ethanol; Glutamic Acid; Humans; Illicit Drugs; Ketamine; Neurotoxicity Syndromes; Oxidative Stress; Sodium Oxybate; Substance Withdrawal Syndrome; Substance-Related Disorders; Succinate-Semialdehyde Dehydrogenase | 2012 |
Targeting the glutamatergic system to treat major depressive disorder: rationale and progress to date.
Topics: Antidepressive Agents; Depressive Disorder, Major; Glutamic Acid; Humans; Ketamine; Molecular Targeted Therapy; Randomized Controlled Trials as Topic; Receptors, N-Methyl-D-Aspartate; Treatment Outcome | 2012 |
Capturing the angel in "angel dust": twenty years of translational neuroscience studies of NMDA receptor antagonists in animals and humans.
Topics: Allosteric Regulation; Animals; Antipsychotic Agents; Brief Psychiatric Rating Scale; Cerebral Cortex; Disease Models, Animal; Dopamine; Emotions; Glutamic Acid; Humans; Ketamine; Neurosciences; Phencyclidine; Psychoses, Substance-Induced; Receptor, Metabotropic Glutamate 5; Receptors, Dopamine D2; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Synapses; Translational Research, Biomedical | 2012 |
Glutamatergic synaptic dysregulation in schizophrenia: therapeutic implications.
Topics: Animals; Cognition; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Ketamine; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Synapses; Synaptic Transmission | 2012 |
Ketamine as a fast acting antidepressant: current knowledge and open questions.
Topics: Animals; Antidepressive Agents; Clinical Trials as Topic; Depression; Drug Evaluation, Preclinical; Glutamic Acid; Humans; Ketamine | 2013 |
Rapid-acting glutamatergic antidepressants: the path to ketamine and beyond.
Topics: Animals; Antidepressive Agents; Depression; Glutamic Acid; Humans; Ketamine | 2013 |
Glutamate and its receptors in the pathophysiology and treatment of major depressive disorder.
Topics: Animals; Antidepressive Agents; Biomarkers, Pharmacological; Depressive Disorder, Major; Excitatory Amino Acid Agents; Glutamic Acid; Humans; Ketamine; Receptors, Glutamate | 2014 |
Ketamine: promising path or false prophecy in the development of novel therapeutics for mood disorders?
Topics: Animals; Antidepressive Agents; Drug Discovery; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Ketamine; Mood Disorders; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, mu; Substance-Related Disorders; Synaptic Transmission | 2015 |
Ketamine and rapid-acting antidepressants: a window into a new neurobiology for mood disorder therapeutics.
Topics: Antidepressive Agents; Brain; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Ketamine; Mood Disorders; Neuronal Plasticity; Prefrontal Cortex | 2015 |
Ketamine and other potential glutamate antidepressants.
Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; Glutamic Acid; Humans; Ketamine; Memantine; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Treatment Outcome | 2015 |
Two cellular hypotheses explaining the initiation of ketamine's antidepressant actions: Direct inhibition and disinhibition.
Topics: Animals; Antidepressive Agents; Brain; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Electroconvulsive Therapy; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Interneurons; Ketamine; Models, Neurological; Neural Inhibition; Neuronal Plasticity; Neurons; Protein Subunits; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2016 |
Emerging treatment mechanisms for depression: focus on glutamate and synaptic plasticity.
Topics: Animals; Antidepressive Agents; Depression; Depressive Disorder, Major; Excitatory Amino Acid Agents; GABA-A Receptor Agonists; Glutamic Acid; Humans; Ketamine; Muscarinic Antagonists; Neuronal Plasticity; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Scopolamine; Stress, Psychological | 2016 |
Glutamate-Based Drug Discovery for Novel Antidepressants.
Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; Drug Design; Drug Discovery; Glutamic Acid; Humans; Ketamine; Molecular Targeted Therapy; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Time Factors | 2016 |
Glutamate and Gamma-Aminobutyric Acid Systems in the Pathophysiology of Major Depression and Antidepressant Response to Ketamine.
Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Ketamine | 2017 |
How much alcohol is in ketamine's antidepressant action?
Topics: Anesthetics, Dissociative; Animals; Antidepressive Agents; Brain; Depressive Disorder; Dopamine; Ethanol; Glutamic Acid; Humans; Ketamine | 2017 |
Targeting glutamate signalling in depression: progress and prospects.
Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; Drug Design; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Ketamine; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2017 |
The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation?
Topics: Animals; Antidepressive Agents; Biomarkers; Depression; Disease Models, Animal; Drug Development; Glutamic Acid; Humans; Ketamine; Synaptic Transmission | 2018 |
The role of glutamatergic modulation in the mechanism of action of ketamine, a prototype rapid-acting antidepressant drug.
Topics: Animals; Antidepressive Agents; Disease Models, Animal; Excitatory Amino Acid Agents; Glutamic Acid; Humans; Ketamine; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synapses | 2018 |
Crosstalk Between Inflammation and Glutamate System in Depression: Signaling Pathway and Molecular Biomarkers for Ketamine's Antidepressant Effect.
Topics: Animals; Antidepressive Agents; Biomarkers; Depression; Glutamic Acid; Humans; Inflammation; Ketamine; Signal Transduction | 2019 |
Fast-acting antidepressant activity of ketamine: highlights on brain serotonin, glutamate, and GABA neurotransmission in preclinical studies.
Topics: Animals; Antidepressive Agents; Brain; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Ketamine; Serotonin; Synaptic Transmission | 2019 |
Novel Pathways in the Treatment of Major Depression: Focus on the Glutamatergic System.
Topics: Depression; Depressive Disorder, Major; Excitatory Amino Acid Agents; Glutamic Acid; Humans; Ketamine; Synaptic Transmission | 2019 |
Neurobiology of rapid-acting antidepressants: convergent effects on GluA1-synaptic function.
Topics: Animals; Antidepressive Agents; Depression; Depressive Disorder, Major; Glutamic Acid; Humans; Ketamine; Neurobiology; Neurogenesis; Neurons; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synapses; Synaptic Transmission | 2019 |
Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments.
Topics: Animals; Antidepressive Agents; Brain; Cerebral Cortex; Depressive Disorder; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Humans; Interneurons; Ketamine; Neurons; Sex Factors; Synaptic Transmission | 2019 |
The potential of
Topics: Acamprosate; Alcoholism; Brain; Central Nervous System Agents; Drug Development; Glutamic Acid; Humans; Ketamine; Neuroimaging; Proton Magnetic Resonance Spectroscopy; Reproducibility of Results | 2021 |
An Update on Glutamatergic System in Suicidal Depression and on the Role of Esketamine.
Topics: Administration, Intranasal; Antidepressive Agents; Clinical Trials as Topic; Databases, Factual; Depression; Depressive Disorder, Major; Drug Compounding; Glutamic Acid; Humans; Ketamine; Receptors, N-Methyl-D-Aspartate; Suicide Prevention; Synaptic Transmission; Time Factors; Treatment Outcome; United States; United States Food and Drug Administration | 2020 |
Overlap in the neural circuitry and molecular mechanisms underlying ketamine abuse and its use as an antidepressant.
Topics: Antidepressive Agents; Brain; Cholinergic Neurons; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Excitatory Amino Acid Antagonists; GABA Agents; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Ketamine; Neural Pathways; Norepinephrine; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Serotonin; Substance-Related Disorders | 2020 |
Anorexia nervosa, zinc deficiency and the glutamate system: The ketamine option.
Topics: Animals; Anorexia Nervosa; Dietary Supplements; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Ketamine; Neurogenesis; Neuronal Plasticity; Receptors, N-Methyl-D-Aspartate; Zinc | 2020 |
Pharmacodynamic elucidation of glutamate & dopamine in ketamine-induced anaesthesia.
Topics: Anesthesia; Anesthetics, Dissociative; Animals; Brain; Dopamine; Dopaminergic Neurons; Glutamic Acid; Humans; Ketamine; Psychotic Disorders; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2020 |
Clinical overview of NMDA-R antagonists and clinical practice.
Topics: Antidepressive Agents; Depressive Disorder, Major; Glutamic Acid; Humans; Ketamine; Practice Patterns, Physicians'; Receptors, N-Methyl-D-Aspartate | 2020 |
Perisynaptic astrocytes as a potential target for novel antidepressant drugs.
Topics: Antidepressive Agents; Astrocytes; Brain-Derived Neurotrophic Factor; Excitatory Amino Acid Agents; Glutamic Acid; Humans; Ketamine; Mechanistic Target of Rapamycin Complex 1; Potassium; Potassium Channels, Inwardly Rectifying; Synapses | 2021 |
Neuroplasticity as a convergent mechanism of ketamine and classical psychedelics.
Topics: Antidepressive Agents; Glutamic Acid; Hallucinogens; Humans; Ketamine; Neuronal Plasticity | 2021 |
Ketamine as a Treatment for Anorexia Nervosa: A Narrative Review.
Topics: Anorexia Nervosa; Antidepressive Agents; Brain; Comorbidity; Depression; Glutamic Acid; Humans; Ketamine; Neuronal Plasticity | 2021 |
Guanosine as a promising target for fast-acting antidepressant responses.
Topics: Antidepressive Agents; Depression; Depressive Disorder, Treatment-Resistant; Glutamic Acid; Guanosine; Humans; Ketamine | 2022 |
Glutamatergic dysfunction in Schizophrenia.
Topics: Dopamine; Glutamic Acid; Humans; Ketamine; N-Methylaspartate; Schizophrenia | 2022 |
NMDA receptors as therapeutic targets for depression treatment: Evidence from clinical to basic research.
Topics: Animals; Antidepressive Agents; Artificial Intelligence; Depression; Glutamic Acid; Ketamine; Receptors, N-Methyl-D-Aspartate | 2023 |
[Ketamine: a neuropsychotropic drug with an innovative mechanism of action].
Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; Glutamic Acid; Ketamine; N-Methylaspartate; Pharmaceutical Preparations; Receptors, AMPA | 2023 |
23 trial(s) available for glutamic acid and ketamine
| Article | Year |
|---|---|
Subanesthetic doses of ketamine stimulate psychosis in schizophrenia.
Topics: Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; Glutamic Acid; Haloperidol; Humans; Injections, Intravenous; Ketamine; Male; Middle Aged; Psychoses, Substance-Induced; Schizophrenia; Time Factors | 1995 |
Glutamate modulation of dopamine measured in vivo with positron emission tomography (PET) and 11C-raclopride in normal human subjects.
Topics: Adult; Carbon Radioisotopes; Dopamine; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Homovanillic Acid; Humans; Ketamine; Magnetic Resonance Imaging; Male; Neostriatum; Prolactin; Raclopride; Reference Values; Salicylamides; Tomography, Emission-Computed | 1998 |
Antidepressant effects of ketamine in depressed patients.
Topics: Adult; Antidepressive Agents; Depressive Disorder, Major; Dose-Response Relationship, Drug; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Injections, Intravenous; Ketamine; Male; Middle Aged; Psychiatric Status Rating Scales; Receptors, N-Methyl-D-Aspartate; Severity of Illness Index | 2000 |
Clinical and sensorimotor gating effects of ketamine in normals.
Topics: Adult; Affect; Brain; Cardiovascular Physiological Phenomena; Excitatory Amino Acid Antagonists; Glutamic Acid; Hallucinations; Humans; Ketamine; Male; Neural Inhibition; Neurons; Neuropsychological Tests; Reaction Time; Receptors, N-Methyl-D-Aspartate; Reference Values; Reflex, Startle | 2001 |
Ketamine attenuates glutamate-induced mechanical sensitization of the masseter muscle in human males.
Topics: Adult; Analysis of Variance; Double-Blind Method; Drug Interactions; Excitatory Amino Acid Antagonists; Functional Laterality; Glutamic Acid; Humans; Ketamine; Male; Masseter Muscle; Pain Measurement; Pain Threshold; Pressure; Time Factors | 2006 |
Effect of a peripheral NMDA receptor antagonist on glutamate-evoked masseter muscle pain and mechanical sensitization in women.
Topics: Adult; Analgesics; Analysis of Variance; Contraceptives, Oral; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Ketamine; Masseter Muscle; Pain; Pain Measurement; Receptors, N-Methyl-D-Aspartate | 2007 |
Glutamate and the neural basis of the subjective effects of ketamine: a pharmaco-magnetic resonance imaging study.
Topics: Adult; Anticonvulsants; Awareness; Brain; Brief Psychiatric Rating Scale; Cross-Over Studies; Dissociative Disorders; Double-Blind Method; Excitatory Amino Acid Antagonists; Frontal Lobe; Glutamic Acid; Gyrus Cinguli; Humans; Image Enhancement; Image Processing, Computer-Assisted; Infusions, Intravenous; Ketamine; Lamotrigine; Magnetic Resonance Imaging; Male; Oxygen; Premedication; Psychoses, Substance-Induced; Receptors, N-Methyl-D-Aspartate; Statistics as Topic; Triazines | 2008 |
Pharmacological dissection of the paradoxical pain induced by a thermal grill.
Topics: Analgesics; Cold Temperature; Cross-Over Studies; Double-Blind Method; Excitatory Amino Acid Antagonists; Glutamic Acid; Hot Temperature; Humans; Hyperalgesia; Illusions; Ketamine; Naloxone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain Measurement; Pain Threshold; Pain, Intractable; Placebos; Receptors, Glutamate; Receptors, Opioid; Thermosensing | 2008 |
Glutamate-induced temporomandibular joint pain in healthy individuals is partially mediated by peripheral NMDA receptors.
Topics: Adult; Area Under Curve; Double-Blind Method; Estradiol; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Facial Pain; Female; Follow-Up Studies; Glutamic Acid; Gonadal Steroid Hormones; Humans; Injections, Intra-Articular; Ketamine; Male; Pain Measurement; Pain Threshold; Progesterone; Range of Motion, Articular; Receptors, N-Methyl-D-Aspartate; Sex Factors; Temporomandibular Joint Disorders; Testosterone; Young Adult | 2010 |
In vivo effects of ketamine on glutamate-glutamine and gamma-aminobutyric acid in obsessive-compulsive disorder: Proof of concept.
Topics: Adult; Cross-Over Studies; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Ketamine; Male; Obsessive-Compulsive Disorder; Prefrontal Cortex; Proton Magnetic Resonance Spectroscopy; Treatment Outcome | 2015 |
Modulatory effects of ketamine, risperidone and lamotrigine on resting brain perfusion in healthy human subjects.
Topics: Adult; Brain; Dopamine Antagonists; Double-Blind Method; Excitatory Amino Acid Antagonists; Glutamic Acid; Healthy Volunteers; Humans; Ketamine; Lamotrigine; Male; Receptors, N-Methyl-D-Aspartate; Risperidone; Triazines; Young Adult | 2015 |
The effects of low-dose ketamine on the prefrontal cortex and amygdala in treatment-resistant depression: A randomized controlled study.
Topics: Adult; Amygdala; Antidepressive Agents; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Dose-Response Relationship, Drug; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Fluorodeoxyglucose F18; Glutamic Acid; Humans; Ketamine; Linear Models; Male; Middle Aged; Positron-Emission Tomography; Prefrontal Cortex; Psychiatric Status Rating Scales; Radiopharmaceuticals | 2016 |
Temporal Dynamics of Antidepressant Ketamine Effects on Glutamine Cycling Follow Regional Fingerprints of AMPA and NMDA Receptor Densities.
Topics: Adult; Antidepressive Agents; Double-Blind Method; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Ketamine; Magnetic Resonance Spectroscopy; Male; Middle Aged; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Time Factors; Young Adult | 2017 |
The Nucleus Accumbens and Ketamine Treatment in Major Depressive Disorder.
Topics: Adult; Case-Control Studies; Cross-Sectional Studies; Depressive Disorder, Major; Female; Functional Laterality; Glutamic Acid; Hippocampus; Humans; Hypertrophy; Ketamine; Longitudinal Studies; Magnetic Resonance Imaging; Male; Nucleus Accumbens; Proton Magnetic Resonance Spectroscopy; Young Adult | 2017 |
Glutamatergic deficit and schizophrenia-like negative symptoms: new evidence from ketamine-induced mismatch negativity alterations in healthy male humans.
Topics: Adult; Brain; Evoked Potentials, Auditory; Excitatory Amino Acid Antagonists; Glutamic Acid; Healthy Volunteers; Humans; Ketamine; Male; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Single-Blind Method; Young Adult | 2017 |
Utility of Imaging-Based Biomarkers for Glutamate-Targeted Drug Development in Psychotic Disorders: A Randomized Clinical Trial.
Topics: Adult; Antipsychotic Agents; Biomarkers; Brain; Drug Development; Female; Glutamic Acid; Glutamine; Humans; Ketamine; Magnetic Resonance Imaging; Male; Middle Aged; Molecular Targeted Therapy; Neuroimaging; Oxygen; Psychotic Disorders; Receptors, Glutamate; Schizophrenia; Young Adult | 2018 |
Glutamatergic Signaling Drives Ketamine-Mediated Response in Depression: Evidence from Dynamic Causal Modeling.
Topics: Adolescent; Adult; Affect; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Antidepressive Agents; Brain; Cross-Over Studies; Depressive Disorder, Major; Double-Blind Method; Evoked Potentials, Somatosensory; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Infusions, Intravenous; Ketamine; Magnetoencephalography; Male; Middle Aged; Models, Neurological; N-Methylaspartate; Time Factors; Treatment Outcome; Young Adult | 2018 |
7T
Topics: Adult; Antidepressive Agents; Brain; Cross-Over Studies; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Double-Blind Method; Female; Glutamic Acid; Glutamine; Humans; Ketamine; Male; Proton Magnetic Resonance Spectroscopy | 2018 |
Neuronal glutamatergic changes and peripheral markers of cytoskeleton dynamics change synchronically 24 h after sub-anaesthetic dose of ketamine in healthy subjects.
Topics: Adult; Biomarkers; Cytoskeleton; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Ketamine; Magnetic Resonance Spectroscopy; Male; Neuronal Plasticity; Neurons; Sex Factors; Time Factors | 2019 |
Default mode network connectivity change corresponds to ketamine's delayed glutamatergic effects.
Topics: Adult; Connectome; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Gyrus Cinguli; Humans; Ketamine; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Nerve Net; Prefrontal Cortex; Young Adult | 2020 |
Reduced auditory evoked gamma-band response and schizophrenia-like clinical symptoms under subanesthetic ketamine.
Topics: Acoustic Stimulation; Adult; Brain; Evoked Potentials, Auditory; Excitatory Amino Acid Antagonists; Gamma Rhythm; Glutamic Acid; Humans; Ketamine; Male; Schizophrenia; Young Adult | 2019 |
Assessment of Relationship of Ketamine Dose With Magnetic Resonance Spectroscopy of Glx and GABA Responses in Adults With Major Depression: A Randomized Clinical Trial.
Topics: Adult; Antidepressive Agents; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Ketamine; Magnetic Resonance Imaging; Male; Middle Aged; Prefrontal Cortex | 2020 |
Modulatory Effects of Ketamine and Lamotrigine on Cognition: Emotion Interaction in the Brain.
Topics: Anticonvulsants; Brain; Cognition; Emotions; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Ketamine; Lamotrigine | 2023 |
180 other study(ies) available for glutamic acid and ketamine
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Anesthetic properties of riluzole (54274 RP), a new inhibitor of glutamate neurotransmission.
Topics: Anesthetics; Animals; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Glutamic Acid; Injections, Intraperitoneal; Ketamine; Male; Rats; Rats, Inbred Strains; Reflex, Abnormal; Riluzole; Sleep; Synaptic Transmission; Thiazoles; Thiopental | 1992 |
Glutamate, NMDA and NMDA receptor antagonists: cardiovascular effects of intrathecal administration in the rat.
Topics: 2-Amino-5-phosphonovalerate; Analysis of Variance; Animals; Blood Pressure; Glutamates; Glutamic Acid; Heart Rate; Hexamethonium; Hexamethonium Compounds; Injections, Spinal; Ketamine; Male; N-Methylaspartate; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord; Time Factors | 1992 |
Single channel analysis of ketamine interaction with a quisqualate receptor.
Topics: Animals; Dose-Response Relationship, Drug; Electric Stimulation; Female; Glutamates; Glutamic Acid; Grasshoppers; Ion Channel Gating; Ketamine; Kinetics; Membrane Potentials; Muscles; Receptors, AMPA; Receptors, Neurotransmitter | 1992 |
Glutamate release in experimental ischaemia of the retina: an approach using microdialysis.
Topics: Amino Acids; Animals; Dialysis; Glutamates; Glutamic Acid; Ischemia; Ketamine; Male; Rabbits; Reperfusion; Retina; Retinal Diseases; Retinal Vessels | 1992 |
[Role of glutamate intracortical connections in conditioned reflex activity].
Topics: 2-Amino-5-phosphonovalerate; Animals; Cats; Cerebral Cortex; Conditioning, Classical; Evoked Potentials, Somatosensory; Glutamates; Glutamic Acid; Iontophoresis; Ketamine; Kynurenic Acid; Membrane Potentials; Neurons; Receptors, N-Methyl-D-Aspartate | 1992 |
[Relationship between facilitatory effect of piracetam on memory and glutamate receptors].
Topics: Animals; Brain; Discrimination Learning; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Ketamine; Male; Memory; Mice; Piracetam; Receptors, Glutamate; Receptors, Neurotransmitter | 1991 |
Is the site of action of ketamine anesthesia the N-methyl-D-aspartate receptor?
Topics: Action Potentials; Anesthesia; Animals; Differential Threshold; Dose-Response Relationship, Drug; Electrophysiology; Glutamates; Glutamic Acid; Interneurons; Ketamine; Lampreys; Membrane Potentials; Neurons; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Reticular Formation; Synapses | 1990 |
Quinolinate neurotoxicity and glutamatergic structures.
Topics: Age Factors; Animals; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Hippocampus; Injections, Intraventricular; Ketamine; Kynurenic Acid; Male; Neurotoxins; Pyridines; Quinolinic Acid; Quinolinic Acids; Rats; Rats, Inbred Strains | 1990 |
Mechanisms generating the time course of dual component excitatory synaptic currents recorded in hippocampal slices.
Topics: Animals; Aspartic Acid; Dibenzocycloheptenes; Dizocilpine Maleate; Electrophysiology; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Ketamine; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses; Temperature; Time Factors | 1990 |
Quisqualate-induced changes in extracellular sodium and calcium concentrations persist in the combined presence of NMDA and non-NMDA receptor antagonists in rat hippocampal slices.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Evoked Potentials; Extracellular Space; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Ketamine; Membrane Potentials; N-Methylaspartate; Quinoxalines; Quisqualic Acid; Rats; Receptors, N-Methyl-D-Aspartate; Sodium | 1990 |
Direct stimulation of pituitary prolactin release by glutamate.
Topics: Animals; Calcium; Cells, Cultured; Dizocilpine Maleate; Female; Glutamates; Glutamic Acid; Ketamine; Pituitary Gland, Anterior; Prolactin; Receptors, Glutamate; Receptors, Neurotransmitter | 1990 |
Swallowing responses induced by microinjection of glutamate and glutamate agonists into the nucleus tractus solitarius of ketamine-anesthetized rats.
Topics: Animals; Deglutition; Glutamates; Glutamic Acid; Ketamine; Medulla Oblongata; Microinjections; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Inbred Strains | 1990 |
Effects of N-methyl-D-aspartate receptor ligands on yeast sporulation.
Topics: Dizocilpine Maleate; Glutamates; Glutamic Acid; Ketamine; Ligands; Magnesium; Receptors, N-Methyl-D-Aspartate; Saccharomyces cerevisiae; Spores, Fungal; Zinc | 1990 |
Use-dependent block of excitatory amino acid currents in cultured neurons by ketamine.
Topics: Amino Acids; Animals; Aspartic Acid; Cells, Cultured; Electric Conductivity; Glutamates; Glutamic Acid; Hippocampus; Ion Channels; Kainic Acid; Ketamine; Membrane Potentials; Mice; N-Methylaspartate; Spinal Cord | 1987 |
Enhancement of desensitization of quisqualate-type glutamate receptor by the dissociative anaesthetic ketamine.
Topics: Action Potentials; Animals; Concanavalin A; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Grasshoppers; Ion Channels; Ketamine; Kinetics; Membrane Potentials; Muscle Contraction; Muscles; Neuromuscular Junction; Oxadiazoles; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter | 1989 |
Ketamine protects cultured astrocytes from glutamate-induced swelling.
Topics: Animals; Astrocytes; Cell Membrane Permeability; Cells, Cultured; Cerebral Cortex; Glutamates; Glutamic Acid; Ketamine; Rats; Rats, Inbred Strains | 1989 |
Quantitative studies on some antagonists of N-methyl D-aspartate in slices of rat cerebral cortex.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Corpus Callosum; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Kainic Acid; Ketamine; Male; Muscimol; N-Methylaspartate; Neuromuscular Depolarizing Agents; Neurons; Oxadiazoles; Potassium; Quisqualic Acid; Rats; Rats, Inbred Strains; Tetrodotoxin | 1985 |
Action of phencyclidine on synaptic transmission in the hippocampus.
Topics: Acetylcholine; Animals; Drug Interactions; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; Iontophoresis; Ketamine; Male; Phencyclidine; Rats; Synaptic Transmission | 1982 |
Effects of injectable anaesthetics on responses to L-glutamate and on spontaneous synaptic activity in lamprey reticulo-spinal neurones.
Topics: Anesthetics; Animals; Brain Stem; Fishes; Glutamates; Glutamic Acid; Imidazoles; In Vitro Techniques; Iontophoresis; Ketamine; Lampreys; Medulla Oblongata; Membrane Potentials; Neurons; Pentobarbital; Pregnanediones; Reticular Formation; Synapses; Trigeminal Nucleus, Spinal | 1984 |
Attenuation of morphine-induced antinociception by L-glutamic acid at the spinal site in rats.
Topics: Analgesia; Animals; Female; Glutamic Acid; Ketamine; Male; Morphine; Naloxone; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1995 |
Warm and cold signals from the preoptic area: which contribute more to the control of shivering in rats?
Topics: Animals; Cold Temperature; Electromyography; Glutamic Acid; Hot Temperature; Ketamine; Male; Muscle, Skeletal; Muscle, Smooth, Vascular; Preoptic Area; Procaine; Rats; Rats, Wistar; Shivering; Signal Transduction; Skin Temperature; Vasodilation | 1995 |
Excitatory amino acid receptor mediation of sensory inputs to functionally identified dorsal horn neurons in cat spinal cord.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cats; Decerebrate State; Evoked Potentials; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Ketamine; Kynurenic Acid; N-Methylaspartate; Neurons; Quinoxalines; Quisqualic Acid; Receptors, Amino Acid; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synapses | 1993 |
Comparison of the uptake of [3H]glutamate into rat cerebrocortical and cerebellar synaptosomes. Effects of anaesthetic agents.
Topics: Anesthetics; Animals; Biological Transport; Cerebellum; Cerebral Cortex; Female; Glutamic Acid; Ketamine; Kinetics; Propofol; Rats; Synaptosomes; Thiopental; Tritium | 1994 |
Ketamine inhibits glutamate-, N-methyl-D-aspartate-, and quisqualate-stimulated cGMP production in cultured cerebral neurons.
Topics: Animals; Brain; Cells, Cultured; Cyclic GMP; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Ketamine; N-Methylaspartate; Neurons; Nitric Oxide; Nitroprusside; Quisqualic Acid; Rats; Rats, Sprague-Dawley | 1995 |
N-methyl-D-aspartate receptors contribute to guanidinosuccinate-induced convulsions in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Drug Interactions; Female; Glutamates; Glutamic Acid; Guanidines; Kainic Acid; Ketamine; Kynurenic Acid; Male; Mice; Receptors, N-Methyl-D-Aspartate; Seizures; Succinates | 1993 |
Synaptic excitation triggers oscillations during NMDA receptor activation in rat abducens motoneurons.
Topics: 2-Amino-5-phosphonovalerate; Abducens Nerve; Animals; Dizocilpine Maleate; Electrophysiology; Evoked Potentials; Glutamates; Glutamic Acid; Ketamine; Male; Motor Neurons; N-Methylaspartate; Oscillometry; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synapses | 1993 |
Prevention by NMDA receptor antagonists of the centrally-evoked increases of cardiac inotropic responses in rabbits.
Topics: 2-Amino-5-phosphonovalerate; Animals; Blood Pressure; Electric Stimulation; Glutamates; Glutamic Acid; Ketamine; Kynurenic Acid; Male; Myocardial Contraction; Paraventricular Hypothalamic Nucleus; Rabbits; Receptors, N-Methyl-D-Aspartate | 1994 |
Effects of the intracerebroventricular administration of ketamine on centrogenic arrhythmias in anesthetized rats.
Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Aspartic Acid; Cerebral Ventricles; Desipramine; Electrocardiography; European Union; Female; Glutamic Acid; Injections, Intraventricular; Ketamine; Male; Ouabain; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Receptors, N-Methyl-D-Aspartate | 1994 |
Glutamate effects on calcium homeostasis in cerebellar granule cells in primary cultures grown under depolarizing and nondepolarizing conditions.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Calcium Radioisotopes; Cells, Cultured; Cerebellum; Cytosol; Glutamates; Glutamic Acid; Homeostasis; Kainic Acid; Ketamine; Mice; Nerve Tissue Proteins; Neuromuscular Depolarizing Agents; Potassium; Quisqualic Acid | 1993 |
The effects of ketamine-isomers on neuronal injury and regeneration in rat hippocampal neurons.
Topics: Anesthetics, Dissociative; Animals; Axons; Cell Survival; Cells, Cultured; Dendrites; Glutamic Acid; Hippocampus; Isomerism; Ketamine; Nerve Degeneration; Nerve Regeneration; Rats; Rats, Sprague-Dawley | 1996 |
Glutamate pharmacology and the treatment of schizophrenia: current status and future directions.
Topics: Autoradiography; Blood Flow Velocity; Cerebrovascular Circulation; Glutamic Acid; Hippocampus; Humans; Ketamine; Neurotransmitter Agents; RNA, Messenger; Schizophrenia | 1995 |
Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Analysis of Variance; Animals; Cognition; Corpus Striatum; Dopamine; Glutamic Acid; Homoserine; Isoquinolines; Ketamine; Maze Learning; Prefrontal Cortex; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Stereotaxic Techniques; Tetrazoles | 1997 |
Characterization of [3H]MK-801 binding to N-methyl-D-aspartate receptors in cultured rat cerebellar granule neurons and involvement in glutamate-mediated toxicity.
Topics: Animals; Binding Sites; Cell Membrane; Cells, Cultured; Cerebellum; Dextromethorphan; Dextrorphan; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Ketamine; Kinetics; Neurons; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1996 |
Effect of aspartate and glutamate on nociception, catalepsy and core temperature in rats.
Topics: Adrenergic Uptake Inhibitors; Analgesia; Analgesics, Opioid; Animals; Aspartic Acid; Body Temperature; Catalepsy; Chlorpromazine; Dopamine Antagonists; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Fever; Glutamic Acid; Haloperidol; Hypothermia; Injections, Subcutaneous; Ketamine; Male; Morphine; Naloxone; Narcotic Antagonists; Nociceptors; Rats; Reserpine; Trifluoperazine | 1997 |
Increase of glutamate uptake in astrocytes: a possible mechanism of action of volatile anesthetics.
Topics: Adjuvants, Anesthesia; Anesthetics, Dissociative; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Astrocytes; Cells, Cultured; Drug Interactions; Enflurane; Ethers; Glutamic Acid; Halothane; Hippocampus; Isoflurane; Ketamine; Methyl Ethers; Pentobarbital; Rats; Rats, Wistar; Sevoflurane | 1997 |
Suppression of cyclic guanosine monophosphate formation in rat cerebellar slices by propofol, ketamine and midazolam.
Topics: Anesthetics, Intravenous; Animals; Cerebellum; Cyclic GMP; Depression, Chemical; Glutamic Acid; In Vitro Techniques; Ketamine; Midazolam; N-Methylaspartate; Nitroprusside; Propofol; Rats; Rats, Wistar; Vasodilator Agents | 1997 |
Direct evidence for the role of nitric oxide on the glutamate-induced neuronal death in cultured cortical neurons.
Topics: Animals; Arginine; Cell Death; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Ketamine; Neurons; Nitric Oxide; omega-N-Methylarginine; Penicillamine; Rats; Rats, Wistar | 1998 |
Validation of an EIA kit for determination of total thyroid hormones in rat serum. Effects of different anaesthetics.
Topics: Anesthetics; Animals; Glutamic Acid; Humans; Immunoenzyme Techniques; Ketamine; Male; Pentobarbital; Rats; Rats, Sprague-Dawley; Reagent Kits, Diagnostic; Reproducibility of Results; Sensitivity and Specificity; Thyroxine; Triiodothyronine; Xylazine | 1998 |
Effect of nitrous oxide on excitatory and inhibitory synaptic transmission in hippocampal cultures.
Topics: Animals; Cesium; Choline; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Feedback; Glutamic Acid; Hippocampus; Kainic Acid; Ketamine; Magnesium; Neural Inhibition; Neurons; Neuroprotective Agents; Nitrous Oxide; Nootropic Agents; Propionates; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, GABA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1998 |
Mitochondrial control of acute glutamate excitotoxicity in cultured cerebellar granule cells.
Topics: Adenosine Triphosphate; Animals; Calcium; Cells, Cultured; Cerebellum; Cytoplasm; Excitatory Amino Acid Antagonists; Glutamic Acid; Intracellular Membranes; Ketamine; Mitochondria; Oligomycins; Permeability; Rats; Rats, Wistar; Rotenone; Time Factors; Uncoupling Agents | 1998 |
Nitric oxide (NO) release by glutamate and NMDA in the dorsal horn of the spinal cord: an in vivo electrochemical approach in the rat.
Topics: Animals; Dizocilpine Maleate; Electrochemistry; Excitatory Amino Acid Antagonists; Glutamic Acid; Ketamine; Male; N-Methylaspartate; Nitric Oxide; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1999 |
Effect of ketamine on hypoxic-ischemic brain damage in newborn rats.
Topics: Adenosine Triphosphate; Amino Acids; Animals; Animals, Newborn; Body Weight; Brain; Brain Ischemia; Carotid Artery Diseases; Female; Functional Laterality; Glutamic Acid; Glutamine; Hypoxia, Brain; Ketamine; Male; Neurons; Neuroprotective Agents; Phosphocreatine; Rats; Rats, Wistar; Time Factors | 1999 |
Effects of intravenous anesthetic agents on glutamate release: a role for GABAA receptor-mediated inhibition.
Topics: Anesthetics, Intravenous; Animals; Bicuculline; Cerebral Cortex; Female; GABA Antagonists; GABA-A Receptor Antagonists; Glutamic Acid; In Vitro Techniques; Ketamine; Neurons; Potassium; Propofol; Rats; Rats, Wistar; Receptors, GABA-A; Thiopental | 2000 |
S(+)-ketamine up-regulates neuronal regeneration associated proteins following glutamate injury in cultured rat hippocampal neurons.
Topics: Animals; Cells, Cultured; Embryo, Mammalian; GAP-43 Protein; Glutamic Acid; Hippocampus; Intracellular Membranes; Ketamine; Kinetics; Membrane Potentials; Membrane Proteins; Mitochondria; Nerve Regeneration; Nerve Tissue Proteins; Neurons; Rats; Rats, Sprague-Dawley; Stereoisomerism; Synaptosomal-Associated Protein 25; Time Factors | 2000 |
Effect of glutamic acid and ketamine on morphine-induced analgesic response in rats.
Topics: Analgesics, Opioid; Animals; Area Under Curve; Drug Interactions; Excitatory Amino Acid Antagonists; Glutamic Acid; Ketamine; Microinjections; Morphine; Pain Measurement; Pain Threshold; Peripheral Nervous System; Rats; Rats, Wistar; Reaction Time | 2000 |
Midazolam and ketamine inhibit glutamate release via a cloned human brain glutamate transporter.
Topics: Amino Acid Transport System X-AG; Anesthetics; Animals; ATP-Binding Cassette Transporters; Brain; CHO Cells; Cricetinae; Glutamic Acid; Humans; Ketamine; Midazolam; Potassium Channels; Recombinant Proteins | 2000 |
Extracellular concentrations of taurine, glutamate, and aspartate in the cerebral cortex of rats at the asymptomatic stage of thioacetamide-induced hepatic failure: modulation by ketamine anesthesia.
Topics: Anesthetics, Dissociative; Animals; Aspartic Acid; Body Water; Cerebral Cortex; Extracellular Space; Glutamic Acid; Ketamine; Liver Failure; Male; Microdialysis; Rats; Rats, Wistar; Taurine; Thioacetamide | 2000 |
Effect of glutamate and antagonists of N-methyl-D-aspartate receptors on experimental parkinsonian syndrome in rats.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Excitatory Amino Acid Antagonists; Glutamic Acid; Ketamine; Male; Memantine; Parkinson Disease, Secondary; Rats; Receptors, N-Methyl-D-Aspartate | 2000 |
Effect of the noncompetitive NMDA antagonists MK-801 and ketamine on the spastic Han-Wistar mutant: a rat model of excitotoxicity.
Topics: Animals; Cell Survival; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Ketamine; Longevity; Muscle Spasticity; Neurodegenerative Diseases; Neuroprotective Agents; Neurotoxins; Purkinje Cells; Pyramidal Cells; Rats; Rats, Mutant Strains; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2001 |
Modulation of NMDA receptor function by ketamine and magnesium: Part I.
Topics: Analgesics; Animals; Drug Synergism; Glutamic Acid; Glycine; Ketamine; Magnesium; Oocytes; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Stereoisomerism; Xenopus | 2001 |
Modulation of NMDA receptor function by ketamine and magnesium. Part II: interactions with volatile anesthetics.
Topics: Analgesics; Anesthetics, Inhalation; Animals; Dose-Response Relationship, Drug; Drug Synergism; Glutamic Acid; Glycine; Ketamine; Magnesium; Oocytes; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Xenopus | 2001 |
Delayed stress-induced increase in tissue level of cholecystokinin in rat prefrontal cortex: modulation by microdialysis probe implantation and systemic ketamine.
Topics: Animals; Cholecystokinin; Excitatory Amino Acid Antagonists; Glutamic Acid; Immunohistochemistry; Ketamine; Male; Microdialysis; Neurons; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Stress, Physiological | 2001 |
Ketamine inhibits presynaptic and postsynaptic nicotinic excitation of identified cardiac parasympathetic neurons in nucleus ambiguus.
Topics: Anesthetics, Dissociative; Animals; Bungarotoxins; Dose-Response Relationship, Drug; Electrophysiology; Female; Glutamic Acid; Heart; Heart Rate; In Vitro Techniques; Ion Channel Gating; Ketamine; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Parasympathetic Nervous System; Pregnancy; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Receptors, Presynaptic | 2002 |
Is NMDA receptor hypofunction in schizophrenia associated with a primary hyperglutamatergic state?
Topics: Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Ketamine; Lamotrigine; Models, Biological; Neurons; Pyramidal Cells; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Synaptic Transmission; Triazines | 2002 |
NMDA receptor-mediated mechanism of ketamine-induced facilitation of glutamatergic excitatory synaptic transmission.
Topics: Animals; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Ketamine; Male; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2002 |
The crude extract from the sea anemone, Bunodosoma caissarum elicits convulsions in mice: possible involvement of the glutamatergic system.
Topics: Animals; Cerebral Cortex; Cnidarian Venoms; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Injections, Intraventricular; Ketamine; Reaction Time; Receptors, N-Methyl-D-Aspartate; Sea Anemones; Seizures; Synaptosomes; Trypsin | 2002 |
[Effect of nucleus raphe obscurus on myoelectric activity of sphincter of Oddi in rabbits].
Topics: Animals; Electrophysiology; Female; gamma-Aminobutyric Acid; Glutamic Acid; Ketamine; Male; Microinjections; Rabbits; Raphe Nuclei; Receptors, N-Methyl-D-Aspartate; Sphincter of Oddi | 2001 |
Effects of ketamine and N-methyl-D-aspartate on glutamate and dopamine release in the rat prefrontal cortex: modulation by a group II selective metabotropic glutamate receptor agonist LY379268.
Topics: Amino Acids; Anesthetics, Local; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dopamine; Drug Administration Routes; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Ketamine; Male; Microdialysis; N-Methylaspartate; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Tetrodotoxin; Time Factors | 2003 |
Nucleus raphe obscurus participates in regulation of gallbladder motility through vagus and sympathetic nerves in rabbits.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anura; Excitatory Amino Acid Antagonists; Gallbladder; Gallbladder Emptying; Glutamic Acid; Ketamine; Microinjections; Rabbits; Raphe Nuclei; Receptors, N-Methyl-D-Aspartate; Sympathetic Nervous System; Vagus Nerve | 2002 |
Group II mGlu receptor activation suppresses norepinephrine release in the ventral hippocampus and locomotor responses to acute ketamine challenge.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Analysis of Variance; Animals; Area Under Curve; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Chromatography, High Pressure Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Guanosine 5'-O-(3-Thiotriphosphate); Hippocampus; Humans; Hyperkinesis; In Vitro Techniques; Ketamine; Male; Microdialysis; Motor Activity; Norepinephrine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Metabotropic Glutamate; Schizophrenia; Serotonin; Sulfur Isotopes; Time Factors; Trifluoroethanol; Xanthenes | 2003 |
Effects of local and intravenous anesthetics on the activity of glutamate transporter type 2.
Topics: Anesthetics, Intravenous; Anesthetics, Local; Animals; Brain Ischemia; Bupivacaine; Cell Membrane; Excitatory Amino Acid Transporter 2; Female; Glutamic Acid; Ketamine; Lidocaine; Neuroprotective Agents; Oocytes; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Thiopental; Xenopus laevis | 2003 |
Respiratory pattern modulation by the pedunculopontine tegmental nucleus.
Topics: Analysis of Variance; Animals; Dose-Response Relationship, Drug; Electroencephalography; Glutamic Acid; Hypnotics and Sedatives; Ketamine; Male; Pedunculopontine Tegmental Nucleus; Pentobarbital; Pons; Rats; Rats, Sprague-Dawley; Respiration; Time Factors | 2003 |
Allosteric modulation of [3H]dizocilpine binding to N-methyl-D-aspartate receptor by an endogenous Na+, K+-ATPase inhibitor: dependence on receptor activation.
Topics: Allosteric Regulation; Animals; Binding Sites; Cell Membrane; Cerebral Cortex; Chelating Agents; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Edetic Acid; Egtazic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Ketamine; Kinetics; Magnesium; Male; Ouabain; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Regression Analysis; Sodium-Potassium-Exchanging ATPase; Time Factors; Tritium | 2004 |
Extracellular taurine in the substantia nigra: taurine-glutamate interaction.
Topics: Adrenergic Agents; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Brain Chemistry; Calcium; Chelating Agents; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Excitatory Amino Acid Antagonists; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Ketamine; Male; Membrane Potentials; Microdialysis; N-Methylaspartate; Oxidopamine; Potassium; Rats; Rats, Sprague-Dawley; Substantia Nigra; Taurine; Time Factors; Zinc | 2004 |
Participation of caudal ventrolateral medulla in the regulation of gallbladder motility in rabbits.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anura; Excitatory Amino Acid Antagonists; Female; Gallbladder; Gallbladder Emptying; gamma-Aminobutyric Acid; Glutamic Acid; Ketamine; Male; Medulla Oblongata; Microinjections; Neural Pathways; Pressure; Rabbits; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sympathetic Nervous System | 2004 |
Ketamine induces dopamine-dependent depression of evoked hippocampal activity in the nucleus accumbens in freely moving rats.
Topics: Animals; Disease Models, Animal; Dopamine; Electric Stimulation; Evoked Potentials; Fornix, Brain; Glutamic Acid; Hippocampus; Ketamine; Male; Neural Pathways; Neuronal Plasticity; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Synaptic Transmission | 2005 |
The NR3B subunit does not alter the anesthetic sensitivities of recombinant N-methyl-D-aspartate receptors.
Topics: Amino Acid Sequence; Anesthetics; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Central Nervous System Depressants; Ethanol; Glutamic Acid; Glycine; Ketamine; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Nitrous Oxide; Oocytes; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; RNA, Messenger; Xenopus | 2005 |
Cortical glutamate-dopamine interaction and ketamine-induced psychotic symptoms in man.
Topics: Adult; Animals; Carbon Radioisotopes; Cerebral Cortex; Dopamine; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Ketamine; Male; Microdialysis; Positron-Emission Tomography; Psychoses, Substance-Induced; Pyrrolidines; Rats; Salicylamides | 2005 |
Combined therapy with clonidine and amantadine may act in two stages of glutamate-mediated neuropathic pain caused by a needle puncture in an upper extremity.
Topics: Adrenergic alpha-Agonists; Adult; Amantadine; Analgesics, Non-Narcotic; Calcium Channel Blockers; Catheterization, Peripheral; Clonidine; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Ketamine; Median Nerve; Pain; Peripheral Nervous System Diseases; Receptors, N-Methyl-D-Aspartate | 2005 |
Effects of intravenous anesthetics on the activity of glutamate transporter EAAT3 expressed in Xenopus oocytes: evidence for protein kinase C involvement.
Topics: Alkaloids; Anesthetics, Intravenous; Animals; Benzophenanthridines; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etomidate; Excitatory Amino Acid Transporter 3; Female; Glutamic Acid; Ketamine; Membrane Potentials; Oocytes; Phenanthridines; Protein Kinase C; Rats; Staurosporine; Tetradecanoylphorbol Acetate; Thiopental; Xenopus | 2006 |
Ketamine, at a dose that disrupts motor behavior and latent inhibition, enhances prefrontal cortex synaptic efficacy and glutamate release in the nucleus accumbens.
Topics: Animals; Behavior, Animal; Evoked Potentials; Excitatory Amino Acid Antagonists; Freezing Reaction, Cataleptic; Glutamic Acid; Inhibition, Psychological; Ketamine; Male; Motor Activity; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Wistar; Stereotyped Behavior; Synaptic Transmission | 2007 |
Modulation of respiratory pattern and upper airway muscle activity by the pedunculopontine tegmentum: role of NMDA receptors.
Topics: Animals; Brain Mapping; Electroencephalography; Electromyography; Glutamic Acid; Ketamine; Male; Muscle Tonus; Pedunculopontine Tegmental Nucleus; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sleep Apnea Syndromes; Sleep, REM; Tongue | 2006 |
High glycine levels are associated with prepulse inhibition deficits in chronic schizophrenia patients.
Topics: Adult; Blinking; Chronic Disease; Electromyography; Female; Glutamic Acid; Glycine; Humans; Inhibition, Psychological; Ketamine; Male; Receptors, N-Methyl-D-Aspartate; Reflex, Startle; Schizophrenia; Severity of Illness Index | 2007 |
Ketamine-related expression of glutamatergic postsynaptic density genes: possible implications in psychosis.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Cerebral Cortex; Dopamine Plasma Membrane Transport Proteins; Excitatory Amino Acid Antagonists; Gene Expression; Glutamic Acid; Homer Scaffolding Proteins; Ketamine; Male; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; RNA, Messenger; Schizophrenia; Synapses | 2007 |
Study pharmacologic of the GABAergic and glutamatergic drugs on seizures and status epilepticus induced by pilocarpine in adult Wistar rats.
Topics: Amines; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Excitatory Amino Acid Antagonists; Gabapentin; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Ketamine; Male; Muscarinic Agonists; N-Methylaspartate; Phenobarbital; Pilocarpine; Rats; Rats, Wistar; Receptors, GABA; Receptors, Neurotransmitter; Seizures; Status Epilepticus; Vigabatrin | 2007 |
Ketamine "unlocks" the reduced clock-speed effects of cocaine following extended training: evidence for dopamine--glutamate interactions in timing and time perception.
Topics: Animals; Biological Clocks; Cocaine; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Habituation, Psychophysiologic; Ketamine; Learning; Male; Nerve Net; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Perception | 2007 |
(+/-) Ketamine-induced prepulse inhibition deficits of an acoustic startle response in rats are not reversed by antipsychotics.
Topics: Animals; Antipsychotic Agents; Clozapine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Haloperidol; Ketamine; Lamotrigine; Male; Pyridines; Rats; Rats, Sprague-Dawley; Reflex, Startle; Risperidone; Schizophrenia; Sulfonamides; Thiophenes; Triazines | 2007 |
Dopaminergic and glutamatergic regulation of effort- and delay-based decision making.
Topics: Animals; Conditioning, Operant; Decision Making; Dextroamphetamine; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Flupenthixol; Glutamic Acid; Ketamine; Male; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Reward; Satiety Response; Synaptic Transmission | 2008 |
General anesthetics selectively modulate glutamatergic and dopaminergic signaling via site-specific phosphorylation in vivo.
Topics: Anesthetics, Dissociative; Anesthetics, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Blotting, Western; Cerebral Cortex; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Extracellular Signal-Regulated MAP Kinases; Glutamic Acid; Isoflurane; Ketamine; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Nerve Tissue Proteins; Neuroprotective Agents; Phosphorylation; Propofol; Receptors, Glutamate; Signal Transduction; Tyrosine 3-Monooxygenase | 2007 |
Glutamate-induced c-Jun expression in neuronal PC12 cells: the effects of ketamine and propofol.
Topics: Analgesics; Anesthetics, Intravenous; Animals; Blotting, Western; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Gene Expression; Glutamic Acid; In Situ Nick-End Labeling; Ketamine; Neurons; Neuroprotective Agents; PC12 Cells; Propofol; Proto-Oncogene Proteins c-jun; Rats | 2008 |
Implication of neuronal Ca2+ -sensor protein VILIP-1 in the glutamate hypothesis of schizophrenia.
Topics: Animals; Calcium; Cells, Cultured; Dentate Gyrus; Female; Glutamic Acid; Hippocampus; Humans; Interneurons; Intracellular Calcium-Sensing Proteins; Ketamine; Male; Neurocalcin; Neurons; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, Nicotinic; Schizophrenia | 2008 |
Toluene has antidepressant-like actions in two animal models used for the screening of antidepressant drugs.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Clomipramine; Desipramine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Hindlimb Suspension; Ketamine; Male; Mice; Motor Activity; Psychomotor Performance; Solvents; Swimming; Toluene | 2009 |
Potency, voltage-dependency, agonist concentration-dependency, blocking kinetics and partial untrapping of the uncompetitive N-methyl-D-aspartate (NMDA) channel blocker memantine at human NMDA (GluN1/GluN2A) receptors.
Topics: Animals; Cell Line; Cerebral Cortex; Dizocilpine Maleate; Glutamic Acid; Humans; In Vitro Techniques; Ion Channel Gating; Ketamine; Kinetics; Male; Memantine; Patch-Clamp Techniques; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2009 |
Glutaminase-deficient mice display hippocampal hypoactivity, insensitivity to pro-psychotic drugs and potentiated latent inhibition: relevance to schizophrenia.
Topics: Acoustic Stimulation; Amphetamine; Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Central Nervous System Stimulants; Clozapine; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Exploratory Behavior; Freezing Reaction, Cataleptic; Glutamic Acid; Glutaminase; Hippocampus; Image Processing, Computer-Assisted; Inhibition, Psychological; Ketamine; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Maze Learning; Memory, Short-Term; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Motor Activity; Oxygen; Protons; Reflex, Startle; Synaptic Transmission | 2009 |
Podocyte glutamatergic signaling contributes to the function of the glomerular filtration barrier.
Topics: Animals; Cells, Cultured; Cytoskeleton; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Exocytosis; Female; Glomerular Filtration Rate; Glutamic Acid; Ketamine; Kidney Diseases; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Knockout; Podocytes; rab3A GTP-Binding Protein; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2009 |
Mazindol attenuates ketamine-induced cognitive deficit in the attentional set shifting task in rats.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Attention; Behavior, Animal; Brain Chemistry; Central Nervous System Stimulants; Cognition Disorders; Discrimination, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Imidazoles; Indoles; Ketamine; Male; Mazindol; Microdialysis; Neuropsychological Tests; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley | 2010 |
Role of neuronal NMDA and non-NMDA glutamate receptors in medial vestibular nucleus in the regulation of respiratory rhythmogenesis in newborn rats in vitro.
Topics: Animals; Animals, Newborn; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutamine; Ketamine; Periodicity; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Respiration; Respiratory Center; Vestibular Nuclei | 2009 |
Tyrosine phosphorylation of the N-Methyl-D-Aspartate receptor 2B subunit in spinal cord contributes to remifentanil-induced postoperative hyperalgesia: the preventive effect of ketamine.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Hyperalgesia; Inflammation Mediators; Ketamine; Male; Nociceptors; Pain, Postoperative; Phosphorylation; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Remifentanil; Spinal Cord; Synaptic Transmission; Tyrosine | 2009 |
The NADPH oxidase NOX2 controls glutamate release: a novel mechanism involved in psychosis-like ketamine responses.
Topics: Animals; Disease Models, Animal; Glutamic Acid; Ketamine; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; NADPH Oxidase 2; NADPH Oxidases; Prefrontal Cortex; Psychoses, Substance-Induced; Reactive Oxygen Species | 2010 |
The improvement of the anti-hyperalgesic effect of ketamine and of its isomers by the administration of ifenprodil.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Catalepsy; Dose-Response Relationship, Drug; Glutamic Acid; Glycine; Hyperalgesia; Injections, Spinal; Isomerism; Ketamine; Male; Motor Activity; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2010 |
Cracking the moody brain: lifting the mood with ketamine.
Topics: Antidepressive Agents; Depression; Glutamic Acid; Humans; Ketamine; Models, Neurological; Protein Binding; Receptors, N-Methyl-D-Aspartate; Signal Transduction; TOR Serine-Threonine Kinases | 2010 |
The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [(1)H]-MRS.
Topics: Adult; Aged; Antidepressive Agents; Blood Pressure; Depressive Disorder, Major; Dissociative Disorders; Female; gamma-Aminobutyric Acid; Glutamic Acid; Heart Rate; Humans; Ketamine; Magnetic Resonance Spectroscopy; Male; Middle Aged; Occipital Lobe; Protons; Psychiatric Status Rating Scales; Psychometrics; Retrospective Studies; Single-Blind Method; Statistics as Topic; Time Factors; Young Adult | 2011 |
Glutamate antagonism fails to reverse mitochondrial dysfunction in late phase of experimental neonatal asphyxia in rats.
Topics: Animals; Animals, Newborn; Asphyxia; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Ketamine; Mitochondria; Oxidative Stress; Pregnancy; Rats; Time Factors | 2011 |
In vivo and ex vivo evidence for ketamine-induced hyperglutamatergic activity in the cerebral cortex of the rat: Potential relevance to schizophrenia.
Topics: Animals; Cerebral Cortex; Glutamic Acid; In Vitro Techniques; Ketamine; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Sprague-Dawley; Schizophrenia | 2011 |
Lack of effect of ketamine on cortical glutamate and glutamine in healthy volunteers: a proton magnetic resonance spectroscopy study.
Topics: Adult; Cerebral Cortex; Depressive Disorder, Major; Female; Glutamic Acid; Glutamine; Humans; Ketamine; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Protons; Young Adult | 2012 |
Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord.
Topics: Analgesics; Animals; Diazepam; Disease Models, Animal; Excitatory Postsynaptic Potentials; Flumazenil; Formaldehyde; GABA Modulators; gamma-Aminobutyric Acid; Glutamic Acid; Hyperalgesia; Ketamine; Male; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Stress, Psychological; Swimming; Time Factors | 2011 |
Is the acute NMDA receptor hypofunction a valid model of schizophrenia?
Topics: Animals; Corpus Callosum; Disease Models, Animal; Dopamine; Glutamic Acid; Humans; Ketamine; Parvalbumins; Phencyclidine; Receptor, Serotonin, 5-HT2A; Receptors, N-Methyl-D-Aspartate; Rodentia; Schizophrenia; Serotonin | 2012 |
An investigation of amino-acid neurotransmitters as potential predictors of clinical improvement to ketamine in depression.
Topics: Adult; Cerebral Cortex; Depressive Disorder, Major; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Ketamine; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neurotransmitter Agents; Predictive Value of Tests; Psychiatric Status Rating Scales; Retrospective Studies | 2012 |
¹H-[¹³C]-nuclear magnetic resonance spectroscopy measures of ketamine's effect on amino acid neurotransmitter metabolism.
Topics: Affect; Animals; Carbon Isotopes; Cognition; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Hippocampus; Hydrogen; Ketamine; Magnetic Resonance Spectroscopy; Male; Neuroglia; Neurotransmitter Agents; Perception; Prefrontal Cortex; Radionuclide Imaging; Rats; Rats, Sprague-Dawley | 2012 |
Ketamine effects on brain GABA and glutamate levels with 1H-MRS: relationship to ketamine-induced psychopathology.
Topics: Brain; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Ketamine; Magnetic Resonance Spectroscopy; Male; Protons; Psychiatric Status Rating Scales; Psychopathology | 2012 |
Effect of modulating the allosteric sites of N-methyl-D-aspartate receptors in ischemia-reperfusion induced acute kidney injury.
Topics: Acute Kidney Injury; Allosteric Site; Animals; Catalase; Glutamic Acid; Glutathione; Ketamine; Kynurenic Acid; Magnesium Sulfate; Male; Models, Animal; Oxidative Stress; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; Spermidine; Superoxides; Thiobarbituric Acid Reactive Substances | 2013 |
Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driver.
Topics: Amino Acids; Animals; Atrophy; Brain Mapping; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Follow-Up Studies; Functional Laterality; Glutamic Acid; Hippocampus; Humans; Imaging, Three-Dimensional; Ketamine; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Psychotic Disorders; Time Factors | 2013 |
Acute suppression of spontaneous neurotransmission drives synaptic potentiation.
Topics: Analysis of Variance; Animals; Animals, Newborn; Biophysics; Brain-Derived Neurotrophic Factor; Electric Stimulation; Elongation Factor 2 Kinase; Enzyme Inhibitors; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Exploratory Behavior; Feeding Behavior; GABA Antagonists; Gene Expression Regulation; Glutamic Acid; Hippocampus; In Vitro Techniques; Inhibition, Psychological; Ketamine; Locomotion; Mice; Mice, Knockout; Neural Inhibition; Neuronal Plasticity; Patch-Clamp Techniques; Picrotoxin; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Sodium Channel Blockers; Swimming; Synapses; Synaptic Transmission; Tetrodotoxin; Time Factors | 2013 |
In vivo neurometabolic profiling to characterize the effects of social isolation and ketamine-induced NMDA antagonism: a rodent study at 7.0 T.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Gyrus Cinguli; Ketamine; Prefrontal Cortex; Proton Magnetic Resonance Spectroscopy; Rats; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Schizophrenic Psychology; Social Isolation | 2014 |
Glutamate, N-acetyl aspartate and psychotic symptoms in chronic ketamine users.
Topics: Adult; Aspartic Acid; Brain; Female; Glutamic Acid; Glutamine; Humans; Ketamine; Magnetic Resonance Spectroscopy; Male; Psychotic Disorders; Substance-Related Disorders; Young Adult | 2014 |
Trial watch: phase II boost for glutamate-targeted antidepressants.
Topics: Antidepressive Agents; Clinical Trials, Phase II as Topic; Depressive Disorder; Drug Delivery Systems; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Ketamine | 2013 |
Neurobiology of rapid acting antidepressants: role of BDNF and GSK-3β.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Glutamic Acid; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Ketamine; Synaptic Transmission; Time Factors | 2014 |
Current drug development for antidepressants and ideas addressing downstream glutamate: the ketamine example.
Topics: Animals; Antidepressive Agents; Depression; Drug Discovery; Glutamic Acid; Humans; Ketamine | 2014 |
Downregulation of neuregulin 1-ErbB4 signaling in parvalbumin interneurons in the rat brain may contribute to the antidepressant properties of ketamine.
Topics: Animals; Antidepressive Agents; Brain; Depression; Down-Regulation; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Interneurons; Ketamine; Locomotion; Male; Neuregulin-1; Parvalbumins; Rats; Rats, Wistar; Receptor, ErbB-4; Signal Transduction | 2014 |
NMDA receptor antagonists ketamine and Ro25-6981 inhibit evoked release of glutamate in vivo in the subiculum.
Topics: Animals; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Ketamine; Male; Mice; Mice, Inbred C57BL; Microelectrodes; Phenols; Piperidines; Prefrontal Cortex; Random Allocation; Receptors, N-Methyl-D-Aspartate | 2014 |
Ketamine alters cortical integration of GABAergic interneurons and induces long-term sex-dependent impairments in transgenic Gad67-GFP mice.
Topics: Animals; Apoptosis; Calcium; Cell Differentiation; Cerebral Cortex; Female; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Green Fluorescent Proteins; Humans; Illicit Drugs; Ketamine; Locomotion; Male; Maternal Exposure; Mice; Mice, Transgenic; Neurons; Pregnancy; Prenatal Exposure Delayed Effects; Receptors, GABA; Sexual Behavior, Animal; Species Specificity; Substance-Related Disorders | 2014 |
Losing control under ketamine: suppressed cortico-hippocampal drive following acute ketamine in rats.
Topics: Animals; Bayes Theorem; CA1 Region, Hippocampal; Catheters, Indwelling; Dose-Response Relationship, Drug; Electrodes, Implanted; Excitatory Amino Acid Antagonists; Gamma Rhythm; gamma-Aminobutyric Acid; Glutamic Acid; Ketamine; Male; Models, Neurological; Neural Pathways; Prefrontal Cortex; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Theta Rhythm | 2015 |
GluN2B-containing NMDA receptors regulate depression-like behavior and are critical for the rapid antidepressant actions of ketamine.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Cerebral Cortex; Depression; Excitatory Postsynaptic Potentials; Gene Knockout Techniques; Glutamic Acid; Ketamine; Mice, Knockout; Neurons; Prefrontal Cortex; Protein Biosynthesis; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 2014 |
α₄β₂ Nicotinic receptor stimulation of the GABAergic system within the orbitofrontal cortex ameliorates the severe crossmodal object recognition impairment in ketamine-treated rats: implications for cognitive dysfunction in schizophrenia.
Topics: Animals; Disease Models, Animal; gamma-Aminobutyric Acid; Glutamic Acid; Ketamine; Male; Neuropsychological Tests; Prefrontal Cortex; Random Allocation; Rats, Long-Evans; Receptors, Nicotinic; Recognition, Psychology; Schizophrenia; Schizophrenic Psychology | 2015 |
Rave drug tested against depression.
Topics: Antidepressive Agents; Brain; Clinical Trials as Topic; Depression; Glutamic Acid; Humans; Ketamine; Neuroimaging; Off-Label Use; Patents as Topic; Suicide; Suicide Prevention; Time Factors | 2015 |
Sex differences in the rapid and the sustained antidepressant-like effects of ketamine in stress-naïve and "depressed" mice exposed to chronic mild stress.
Topics: Animals; Antidepressive Agents; Aspartic Acid; Chronic Disease; Depressive Disorder; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Glutamic Acid; Hippocampus; Ketamine; Male; Mice, Inbred C57BL; Prefrontal Cortex; Receptors, N-Methyl-D-Aspartate; Serotonin; Sex Characteristics; Stress, Psychological; Swimming; Time Factors | 2015 |
Observation of Distressed Conspecific as a Model of Emotional Trauma Generates Silent Synapses in the Prefrontal-Amygdala Pathway and Enhances Fear Learning, but Ketamine Abolishes those Effects.
Topics: Animals; Avoidance Learning; Basolateral Nuclear Complex; Disease Models, Animal; Electroshock; Fear; Glutamic Acid; Ketamine; Male; Mice, 129 Strain; Mice, Inbred C57BL; Neural Pathways; Prefrontal Cortex; Psychotropic Drugs; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Stress, Psychological; Synapses; Synaptic Transmission; Tissue Culture Techniques; Visual Perception | 2015 |
Aggression and increased glutamate in the mPFC during withdrawal from intermittent alcohol in outbred mice.
Topics: Aggression; Animals; Behavior, Animal; Ethanol; Excitatory Amino Acid Antagonists; Glutamic Acid; Ketamine; Male; Memantine; Mice; Prefrontal Cortex; Receptors, N-Methyl-D-Aspartate; Social Behavior; Substance Withdrawal Syndrome | 2015 |
Only extra-high dose of ketamine affects l-glutamate-induced intracellular Ca(2+) elevation and neurotoxicity.
Topics: Anesthetics, Intravenous; Animals; Calcium; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Embryo, Mammalian; GABA Agonists; Glutamic Acid; Ketamine; Rats, Wistar; Thiopental | 2015 |
Long-term NMDA receptor inhibition affects NMDA receptor expression and alters glutamatergic activity in developing rat hippocampal neurons.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Calcium; Calcium Signaling; Caspase 3; Cells, Cultured; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enzyme Activation; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Ketamine; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; RNA, Messenger; Synaptic Transmission; Time Factors; Up-Regulation | 2015 |
Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1.
Topics: Animals; Autoradiography; Brain; CA1 Region, Hippocampal; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Ketamine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Neural Pathways; Patch-Clamp Techniques; Prefrontal Cortex; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Thalamus | 2015 |
The positive effect on ketamine as a priming adjuvant in antidepressant treatment.
Topics: Animals; Antidepressive Agents; Anxiety; Aspartic Acid; Behavior, Animal; Brain; Depression; Depressive Disorder, Major; Disease Models, Animal; Drug Therapy, Combination; Fluoxetine; Glutamic Acid; Imipramine; Ketamine; Male; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Wistar; Stress, Psychological | 2015 |
Sex differences in glutamate receptor gene expression in major depression and suicide.
Topics: Adult; Case-Control Studies; Depressive Disorder, Major; Female; Gene Expression; Glutamic Acid; Humans; Ketamine; Male; Prefrontal Cortex; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Sex Factors; Suicide; Transcriptome | 2015 |
A pilot in vivo proton magnetic resonance spectroscopy study of amino acid neurotransmitter response to ketamine treatment of major depressive disorder.
Topics: Adult; Amino Acids; Antidepressive Agents; Brain; Depressive Disorder, Major; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Ketamine; Magnetic Resonance Imaging; Male; Middle Aged; Neurotransmitter Agents; Pilot Projects; Proton Magnetic Resonance Spectroscopy; Psychiatric Status Rating Scales; Tritium | 2016 |
Bidirectional Homeostatic Regulation of a Depression-Related Brain State by Gamma-Aminobutyric Acidergic Deficits and Ketamine Treatment.
Topics: Animals; Behavior, Animal; Depressive Disorder, Major; Down-Regulation; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Homeostasis; Ketamine; Mice; Prefrontal Cortex; Receptors, AMPA; Receptors, GABA-A; Receptors, N-Methyl-D-Aspartate; Synapses | 2016 |
Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects.
Topics: Animals; Antidepressive Agents; Brain; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Ketamine; Magnetic Resonance Spectroscopy; Male; Phenols; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Scopolamine | 2017 |
A heuristic model for working memory deficit in schizophrenia.
Topics: Brain; Computer Simulation; gamma-Aminobutyric Acid; Glutamic Acid; Heuristics; Humans; Ketamine; Memory Disorders; Memory, Short-Term; Models, Biological; Neurons; Neurotransmitter Agents; Schizophrenia | 2016 |
A single dose of vortioxetine, but not ketamine or fluoxetine, increases plasticity-related gene expression in the rat frontal cortex.
Topics: Animals; Antidepressive Agents; Dose-Response Relationship, Drug; Fluoxetine; Frontal Lobe; Gene Expression Regulation; Glutamic Acid; Ketamine; Male; Neuronal Plasticity; Piperazines; Rats; Rats, Sprague-Dawley; Serotonin; Sulfides; Time Factors; Vortioxetine | 2016 |
Repeated ketamine treatment induces sex-specific behavioral and neurochemical effects in mice.
Topics: Animals; Antidepressive Agents; Anxiety; Aspartic Acid; Depression; Female; Glutamic Acid; Hippocampus; Hydroxyindoleacetic Acid; Ketamine; Male; Mice; Mice, Inbred C57BL; Serotonin; Sex Characteristics; SNARE Proteins; Synapsins; Syntaxin 1 | 2016 |
Ketamine modulates hippocampal neurochemistry and functional connectivity: a combined magnetic resonance spectroscopy and resting-state fMRI study in healthy volunteers.
Topics: Adult; Brain; Female; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Healthy Volunteers; Hippocampus; Humans; Ketamine; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Neurochemistry; Neuroimaging; Prefrontal Cortex; Rest | 2017 |
GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers.
Topics: Amino Acid Sequence; Base Sequence; Cell Death; Child; Dendrites; DNA Mutational Analysis; Electroencephalography; Exome; Female; Genes, Dominant; Glutamic Acid; Humans; Infant; Infant, Newborn; Ketamine; Magnesium; Memantine; Models, Molecular; Mutation; Precision Medicine; Receptors, N-Methyl-D-Aspartate; Seizures; Spasms, Infantile | 2016 |
Metabolomic signatures of drug response phenotypes for ketamine and esketamine in subjects with refractory major depressive disorder: new mechanistic insights for rapid acting antidepressants.
Topics: Adult; Arginine; Citrulline; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Indoleacetic Acids; Infusions, Intravenous; Ketamine; Male; Metabolomics; Methionine; Middle Aged; Ornithine; Phenotype; Phospholipids; Tryptophan; Urea | 2016 |
Ketamine Self-Administration Reduces the Homeostasis of the Glutamate Synapse in the Rat Brain.
Topics: Animals; Brain; Excitatory Amino Acid Antagonists; Glutamic Acid; Homeostasis; Ketamine; Male; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, N-Methyl-D-Aspartate; Self Administration; Synapses | 2017 |
d-Cycloserine, an NMDA Glutamate Receptor Glycine Site Partial Agonist, Induces Acute Increases in Brain Glutamate Plus Glutamine and GABA Comparable to Ketamine.
Topics: Brain Chemistry; Cycloserine; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Glutamine; Humans; Ketamine; Proton Magnetic Resonance Spectroscopy | 2016 |
Nardostachys jatamansi Targets BDNF-TrkB to Alleviate Ketamine-Induced Schizophrenia-Like Symptoms in Rats.
Topics: Animals; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Dopamine; Glutamic Acid; Ketamine; Male; Nardostachys; Phytotherapy; Plant Extracts; Plant Roots; Rats; Receptor, trkB; Schizophrenia | 2016 |
Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [
Topics: Adult; Antidepressive Agents; Brain; Carbon Radioisotopes; Case-Control Studies; Depression; Depressive Disorder, Major; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Ketamine; Male; Positron-Emission Tomography; Receptor, Metabotropic Glutamate 5 | 2018 |
Amygdala activity associated with social choice in mice.
Topics: Amygdala; Animals; Choice Behavior; Electrocorticography; Excitatory Amino Acid Antagonists; Gamma Rhythm; Glutamic Acid; Ketamine; Male; Mice, Inbred C57BL; Psychological Tests; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Social Behavior; Theta Rhythm | 2017 |
Neuropharmacological characterization of the new psychoactive substance methoxetamine.
Topics: Animals; Calcium; Calcium Channels; Carrier Proteins; Cations, Divalent; Cell Line, Tumor; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Cyclohexanones; Cyclohexylamines; Glutamic Acid; Glycerol Kinase; HEK293 Cells; Humans; Induced Pluripotent Stem Cells; Ketamine; Neurons; Psychotropic Drugs; Rats, Wistar; Vesicular Monoamine Transport Proteins | 2017 |
Ketamine attenuates the glutamatergic neurotransmission in the ventral posteromedial nucleus slices of rats.
Topics: Animals; Dose-Response Relationship, Drug; Excitatory Postsynaptic Potentials; Glutamic Acid; Infusions, Intravenous; Ketamine; Neurons; Rats; Synaptic Transmission; Ventral Thalamic Nuclei | 2017 |
Cortical functional hyperconnectivity in a mouse model of depression and selective network effects of ketamine.
Topics: Animals; Antidepressive Agents; Aspartic Acid; Behavior, Animal; Cerebral Cortex; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Ketamine; Male; Mice; Mice, Transgenic; Neural Pathways; Neurons; Social Behavior; Vesicular Glutamate Transport Proteins; Voltage-Sensitive Dye Imaging | 2017 |
Functional interaction between N-methyl-D-aspartate receptor and ascorbic acid during neuropathic pain induced by chronic constriction injury of the sciatic nerve.
Topics: Analgesics; Animals; Ascorbic Acid; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Ketamine; Ligation; Male; Neuralgia; Pain Threshold; Peripheral Nerve Injuries; Rats; Receptors, N-Methyl-D-Aspartate; Sciatic Nerve | 2017 |
Ketamine intervention limits pathogen expansion in vitro.
Topics: Anti-Infective Agents; Borrelia burgdorferi; Glutamic Acid; Ketamine; Microbial Sensitivity Tests; Signal Transduction; Stachybotrys; Staphylococcus epidermidis | 2018 |
A reappraisal of the mechanisms of action of ketamine to treat complex regional pain syndrome in the light of cortical excitability changes.
Topics: Adult; Aged; Aged, 80 and over; Analgesics; Cerebral Cortex; Complex Regional Pain Syndromes; Cortical Excitability; Evoked Potentials, Motor; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Ketamine; Male; Middle Aged; Motor Cortex; Young Adult | 2018 |
Alcohol aggravates ketamine-induced behavioral, morphological and neurochemical alterations in adolescent rats: The involvement of CREB-related pathways.
Topics: Animals; Ataxia; Brain; Caspase 3; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Glutamic Acid; Ketamine; Male; Motor Activity; Proto-Oncogene Proteins c-akt; Random Allocation; Rats, Sprague-Dawley; Sexual Maturation; Stereotyped Behavior | 2018 |
Synaptic phospholipids as a new target for cortical hyperexcitability and E/I balance in psychiatric disorders.
Topics: Animals; Astrocytes; Cells, Cultured; Central Nervous System Agents; Cerebral Cortex; Disease Models, Animal; Glutamic Acid; Humans; Ketamine; Lysophospholipids; Mental Disorders; Mice, Inbred C57BL; Mice, Transgenic; Neural Inhibition; Phosphoric Diester Hydrolases; Proteoglycans; Psychotropic Drugs; Synapses; Tissue Culture Techniques; Vesicular Transport Proteins | 2018 |
(2R,6R)-hydroxynorketamine rescues chronic stress-induced depression-like behavior through its actions in the midbrain periaqueductal gray.
Topics: Animals; Antidepressive Agents; Cell Membrane; Cytosol; Depressive Disorder; Disease Models, Animal; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Helplessness, Learned; Ketamine; Male; Miniature Postsynaptic Potentials; Neurons; Periaqueductal Gray; Rats, Sprague-Dawley; Receptors, AMPA; Stress, Psychological; Synapses; Tissue Culture Techniques | 2018 |
Long-Term Neurobehavioral Consequences of a Single Ketamine Neonatal Exposure in Rats: Effects on Cellular Viability and Glutamate Transport in Frontal Cortex and Hippocampus.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Behavior, Animal; Excitatory Amino Acid Antagonists; Exploratory Behavior; Female; Frontal Lobe; Glutamic Acid; Hippocampus; In Vitro Techniques; Ketamine; Male; Rats; Rats, Wistar; Recognition, Psychology; Swimming; Tritium | 2018 |
Role of copper in depression. Relationship with ketamine treatment.
Topics: Anesthetics; Animals; Antidepressive Agents; Copper; Depressive Disorder; Glutamic Acid; Hippocampus; Humans; Ions; Ketamine; Mice; Nerve Tissue Proteins; Neurons; Prion Proteins; Rats; Receptors, N-Methyl-D-Aspartate | 2018 |
Prefrontal cortex miR-29b-3p plays a key role in the antidepressant-like effect of ketamine in rats.
Topics: 3' Untranslated Regions; Animals; Antidepressive Agents; Apoptosis; Calcium; Cell Survival; Disease Models, Animal; Gene Expression; Gene Expression Regulation; Gene Silencing; Glutamic Acid; Ketamine; Male; MicroRNAs; Neurons; Prefrontal Cortex; Rats; RNA Interference; Stress, Psychological | 2018 |
Subchronic ketamine alters behaviour, metabolic indices and brain morphology in adolescent rats: Involvement of oxidative stress, glutamate toxicity and caspase-3-mediated apoptosis.
Topics: Animals; Apoptosis; Behavior, Animal; Brain; Caspase 3; Excitatory Amino Acid Antagonists; Glutamic Acid; Ketamine; Male; Oxidative Stress; Rats; Rats, Wistar | 2019 |
Sex Differences in the Temporal Neuromolecular and Synaptogenic Effects of the Rapid-acting Antidepressant Drug Ketamine in the Mouse Brain.
Topics: Animals; Antidepressive Agents; Brain; Female; Glutamic Acid; Ketamine; Male; Mice, Inbred C57BL; Neuronal Plasticity; Neurons; Sex Characteristics; Synapses; Time Factors | 2019 |
Ketamine normalizes binge drinking-induced defects in glutamatergic synaptic transmission and ethanol drinking behavior in female but not male mice.
Topics: Animals; Binge Drinking; Brain; Elongation Factor 2 Kinase; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Ketamine; Male; Mice; Mice, Inbred C57BL; Models, Animal; Prefrontal Cortex; Receptors, Glutamate; Signal Transduction; Synaptic Transmission; TOR Serine-Threonine Kinases | 2019 |
Is Ketamine Suitable for Use in Glutamate Toxicity Conditions?: An In Vitro Study.
Topics: Cerebral Cortex; Glutamic Acid; Humans; Ketamine; Neuroprotective Agents | 2021 |
(2R,6R)-hydroxynorketamine rapidly potentiates hippocampal glutamatergic transmission through a synapse-specific presynaptic mechanism.
Topics: Animals; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Hippocampus; Ketamine; Male; Organ Culture Techniques; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Synapses; Synaptic Transmission | 2020 |
Role of Serotonin and Noradrenaline in the Rapid Antidepressant Action of Ketamine.
Topics: Animals; Antidepressive Agents; Depression; Dorsal Raphe Nucleus; Glutamic Acid; Ketamine; Male; Motor Activity; Norepinephrine; Prefrontal Cortex; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1A; Serotonergic Neurons; Serotonin | 2019 |
Ketamine induced changes in regional cerebral blood flow, interregional connectivity patterns, and glutamate metabolism.
Topics: Adult; Cerebrovascular Circulation; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Gyrus Cinguli; Hippocampus; Humans; Ketamine; Magnetic Resonance Spectroscopy; Male; Nerve Net; Putamen; Young Adult | 2019 |
Ketamine treatment affects hippocampal but not cortical mitochondrial function in prepubertal rats.
Topics: Animals; Apoptosis; Catalase; Cerebral Cortex; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Ketamine; Malates; Male; Membrane Potential, Mitochondrial; Mitochondria; Oxidative Stress; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Signal Transduction; Superoxide Dismutase | 2020 |
Extending the Specificity of DRL 72-s Behavior for Screening Antidepressant-Like Effects of Glutamatergic Clinically Validated Anxiolytic or Antidepressant Drugs in Rats.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Bridged Bicyclo Compounds; Cognition; Drug Evaluation, Preclinical; Executive Function; Glutamic Acid; Impulsive Behavior; Ketamine; Male; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Reproducibility of Results | 2020 |
Withdrawal from chronic ethanol exposure increases postsynaptic glutamate function of insular cortex projections to the rat basolateral amygdala.
Topics: Administration, Inhalation; Alcoholism; Animals; Basolateral Nuclear Complex; Central Nervous System Depressants; Cerebral Cortex; Electric Stimulation; Electrophysiological Phenomena; Ethanol; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Ketamine; Male; Neural Pathways; Optogenetics; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 2020 |
Effects of JL13, a pyridobenzoxazepine compound, in dopaminergic and glutamatergic models of antipsychotic activity.
Topics: Animals; Antipsychotic Agents; Cocaine; Disease Models, Animal; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Glutamic Acid; Ketamine; Locomotion; Male; Mice; Oxazepines; Piperazines; Pyridines; Reflex, Startle; Schizophrenia | 2021 |
Subanesthetic ketamine with an AMPAkine attenuates motor impulsivity in rats.
Topics: Animals; Antidepressive Agents; Cognition; Dose-Response Relationship, Drug; Glutamic Acid; Impulsive Behavior; Ketamine; Mental Disorders; Neuronal Plasticity; Nootropic Agents; Piracetam; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2021 |
Ketamine Rapidly Enhances Glutamate-Evoked Dendritic Spinogenesis in Medial Prefrontal Cortex Through Dopaminergic Mechanisms.
Topics: Animals; Dendritic Spines; Glutamic Acid; Humans; Ketamine; Mice; Mice, Inbred C57BL; Prefrontal Cortex | 2021 |
A preliminary study of the association of increased anterior cingulate gamma-aminobutyric acid with remission of depression after ketamine administration.
Topics: Depression; Depressive Disorder, Treatment-Resistant; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus Cinguli; Humans; Ketamine | 2021 |
The role of the excitation:inhibition functional balance in the mPFC in the onset of antidepressants.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Excitatory Amino Acid Agents; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Fluoxetine; Glutamic Acid; Inhibitory Postsynaptic Potentials; Interneurons; Ketamine; Male; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Inbred WF; Selective Serotonin Reuptake Inhibitors | 2021 |
Ketamine for a Boost of Neural Plasticity: How, but Also When?
Topics: Antidepressive Agents; Glutamic Acid; Ketamine; Neuronal Plasticity; Prefrontal Cortex | 2021 |
Excitation of Putative Glutamatergic Neurons in the Rat Parabrachial Nucleus Region Reduces Delta Power during Dexmedetomidine but not Ketamine Anesthesia.
Topics: Anesthesia; Anesthetics, Dissociative; Animals; Calcium-Binding Proteins; Delta Rhythm; Dexmedetomidine; Glutamic Acid; Hypnotics and Sedatives; Ketamine; Male; Neurons; Parabrachial Nucleus; Rats; Rats, Sprague-Dawley | 2021 |
Structural basis of ketamine action on human NMDA receptors.
Topics: Antidepressive Agents; Asparagine; Binding Sites; Cryoelectron Microscopy; Glutamic Acid; Glycine; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Ketamine; Leucine; Molecular Dynamics Simulation; Nerve Tissue Proteins; Receptors, N-Methyl-D-Aspartate | 2021 |
Ketamine decreases neuronally released glutamate via retrograde stimulation of presynaptic adenosine A1 receptors.
Topics: Animals; Antidepressive Agents; Depressive Disorder, Major; Glutamic Acid; Humans; Ketamine; Receptor, Adenosine A1; Receptors, N-Methyl-D-Aspartate | 2021 |
Glutamate modulators and beyond: A neuroscience revolution in the making.
Topics: Allosteric Regulation; Glutamic Acid; Ketamine; Neurosciences | 2022 |
Acute effects of ketamine on the pregenual anterior cingulate: linking spontaneous activation, functional connectivity, and glutamate metabolism.
Topics: Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Ketamine; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy | 2022 |
(2R,6R)-hydroxynorketamine rapidly potentiates optically-evoked Schaffer collateral synaptic activity.
Topics: Animals; Antidepressive Agents; Glutamic Acid; Hippocampus; Ketamine; Male; Rats; Rats, Sprague-Dawley | 2022 |
Predicting Antidepressant Effects of Ketamine: the Role of the Pregenual Anterior Cingulate Cortex as a Multimodal Neuroimaging Biomarker.
Topics: Antidepressive Agents; Biomarkers; Depressive Disorder, Major; Glutamic Acid; Gyrus Cinguli; Humans; Ketamine; Magnetic Resonance Imaging | 2022 |
Nitrous Oxide, a Rapid Antidepressant, Has Ketamine-like Effects on Excitatory Transmission in the Adult Hippocampus.
Topics: Animals; Antidepressive Agents; Glutamic Acid; Hippocampus; Ketamine; Nitrous Oxide; Rats; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2022 |
Fast antidepressant action of ketamine in mouse models requires normal VGLUT1 levels from prefrontal cortex neurons.
Topics: Anhedonia; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Animal; Glutamic Acid; Ketamine; Mice; Neurons; Prefrontal Cortex; Reboxetine; Vesicular Glutamate Transport Protein 1 | 2023 |
Intranasal (R, S)-ketamine delivery induces sustained antidepressant effects associated with changes in cortical balance of excitatory/inhibitory synaptic activity.
Topics: Animals; Antidepressive Agents; Excitatory Amino Acid Antagonists; Glutamic Acid; Ketamine; Mice; Receptors, N-Methyl-D-Aspartate | 2023 |
The Effect of Clozapine and Novel Glutamate Modulator JNJ-46356479 on Nitrosative Stress in a Postnatal Murine Ketamine Model of Schizophrenia.
Topics: Adult; Animals; Clozapine; Glutamic Acid; Humans; Ketamine; Mice; Nitrosative Stress; Prefrontal Cortex; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2023 |
Opposite Modulation of the NMDA Receptor by Glycine and S-Ketamine and the Effects on Resting State EEG Gamma Activity: New Insights into the Glutamate Hypothesis of Schizophrenia.
Topics: Biomarkers; Electroencephalography; Glutamic Acid; Humans; Ketamine; Male; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Schizophrenia | 2023 |
Association of the delayed changes in glutamate levels and functional connectivity with the immediate network effects of S-ketamine.
Topics: Antidepressive Agents; Glutamic Acid; Humans; Ketamine; Magnetic Resonance Imaging; Male | 2023 |
NMDA receptor-mediated modulation on glutamine synthetase and glial glutamate transporter GLT-1 is involved in the antidepressant-like and neuroprotective effects of guanosine.
Topics: Amino Acid Transport System X-AG; Animals; Antidepressive Agents; Depression; Excitatory Amino Acid Transporter 2; Glutamate-Ammonia Ligase; Glutamic Acid; Guanosine; Hippocampus; Ketamine; Mice; Molecular Docking Simulation; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate | 2023 |