glutamic acid and clozapine

glutamic acid has been researched along with clozapine in 81 studies

Research

Studies (81)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (2.47)	18.7374
1990's	13 (16.05)	18.2507
2000's	30 (37.04)	29.6817
2010's	23 (28.40)	24.3611
2020's	13 (16.05)	2.80

Authors

Authors	Studies
Bartoccini, F; Carminati, P; Castorina, M; Di Cesare, MA; Di Serio, S; Gallo, G; Ghirardi, O; Giorgi, F; Giorgi, L; Minetti, P; Piersanti, G; Tarzia, G; Tinti, MO	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Hayashi, S; Kato, A; Mizuno, K; Morita, A; Nakata, E; Ohashi, K; Yamamura, K	1
Frølund, B; Gloriam, DE; Isberg, V; Jensen, AA; Krall, J; Krogsgaard-Larsen, P; Pedersen, MH; Plath, N; Stensbøl, TB; Wellendorph, P	1
Mott, J; Sherman, AD	1
Jenner, P; Kerwin, RW; Marsden, CD; Rupniak, NM	1
Chapman, MA; See, RE	1
Banerjee, SP; Lidsky, TI; Yablonsky-Alter, E; Zuck, L	1
Cooperman, MA; Yamamoto, BK	1
Jayaraman, A; Kiba, H	1
Daly, DA; Moghaddam, B	1
Banerjee, SP; Lidsky, TI; Yablonsky-Alter, E; Zuck, LG	1
Allen, C; Bunker, GL; Janowsky, A; Mason, JN; Meshul, CK	1
Tollefson, GD	1
Amico, ET; Evins, AE; Goff, DC; Shih, V	1
Breier, A	1
Caron, MG; Gainetdinov, RR; Koller, BH; Mohn, AR	1
Baca, SM; Hyde, TM; Jaskiw, GE; Kleinman, JE; Murray, AM; Spurney, CF	1
Böhmer, C; Centelles, JJ; Kinne, RK; Palmada, M	1
Halliwell, JV; Owen, GS	1
Conti, F; Cozzi, A; Matute, C; Melone, M; Pellegrini-Giampietro, DE; Pérez-Samartin, A; Rothstein, JD; Vallejo-Illarramendi, A; Vitellaro-Zuccarello, L	1
Pittman, QJ; Price, CJ	1
De Luca, L; Fabrazzo, M; Maj, M; Monteleone, P; Tortorella, A; Viggiano, A	1
Adams, BW; Moghaddam, B	1
Carlsson, A; Carlsson, ML; Nilsson, M; Waters, N; Waters, S	1
Chen, L; Yang, CR	1
Bijak, M; Gołembiowska, K; Ossowska, K; Pietraszek, M; Wolfarth, S	1
Bragina, L; Conti, F; Melone, M	1
Ninan, I; Wang, RY	1
Becker, H; Blin, O; Micallef, J; Tardieu, S	1
Abekawa, T; Honda, M; Ito, K; Koyama, T	1
Coyle, JT; Javitt, DC	1
Wang, SJ; Yang, TT	1
Engberg, G; Erhardt, S; Linderholm, KR; Nilsson, LK; Schwieler, L	1
Conti, F; Matute, C; Melone, M; Torres-Ramos, M; Vallejo-Illarramendi, A	1
Hertel, P; Jardemark, KE; Langlois, X; Marcus, MM; Svensson, TH; Wadenberg, ML	1
MacDonald, CJ; Meck, WH	1
Giménez-Amaya, JM; Haroutunian, V; Huerta, I; McCullumsmith, RE; Meador-Woodruff, JH	1
Javitt, DC	1
Hertel, P; Jardemark, KE; Konradsson, A; Marcus, MM; Svensson, TH	1
Abekawa, T; Ito, K; Koyama, T	2
Balaraman, Y; Edenberg, HJ; Faraone, SV; Geyer, MA; Jerome, RE; Kuczenski, R; Le-Niculescu, H; Niculescu, AB; Nurnberger, JI; Patel, S; Sidhu, K; Tan, J; Tsuang, MT	1
Adell, A; Amargós-Bosch, M; Artigas, F; Babot, Z; López-Gil, X; Suñol, C	1
Markou, A; Paterson, NE	1
Cilia, J; Hatcher, P; Jones, DN; Reavill, C	1
Arancio, O; Balsam, P; Chuhma, N; Conjard-Duplany, A; Fairhurst, S; Gaisler-Salomon, I; Galloway, MP; Ghoddoussi, F; Hen, R; Lee, S; Lewandowski, N; Masson, J; Miller, GM; Moore, HM; Rayport, S; Small, SA; Wang, Y; Zhang, H	1
Jardemark, KE; Konradsson, A; Marcus, MM; Schilström, B; Svensson, TH	1
Arnt, J; Calcagno, E; Carli, M; Invernizzi, RW; Mainini, E	1
Cecil, KM; Dunn, RS; Lindquist, DM	1
Motomura, E; Nakagawa, M; Okada, M; Tanahashi, S; Yamamura, S	1
Howells, FM; Mc Fie, S; Russell, VA; Sterley, TL	1
Cohn, T; Hahn, MK; Remington, G; Teo, C	1
Begemann, MJ; de Haan, L; Engelsbel, F; Schulte, PF; Veerman, SR	1
de Haan, L; Schulte, PF; Veerman, SR	1
Fujimoto, M; Fujita, Y; Hashimoto, K; Hashimoto, R; Ito, A; Numata, S; Ohi, K; Ohmori, T; Takeda, M; Umeda-Yano, S; Yamamori, H; Yasuda, Y	1
Chaki, S; Hiyoshi, T; Kambe, D; Karasawa, J	1
Anderson, VM; Goldstein, ME; Kydd, RR; Pillai, A; Russell, BR	1
Boger, HA; Haydon, PG; Kalivas, PW; Li, H; Scofield, MD; Smith, RJ	1
Hall, K; Lewitt, M; Melkersson, K	1
Bagley, EE; McNally, GP; Sengupta, A; Winters, B	1
Gil-Ad, I; Krivoy, A; Taler, M; Tarasenko, I; Weizman, A	1
Belardo, C; Bertolino, A; Bolognesi, P; Errico, F; Frassineti, M; Iannotta, M; Maione, S; Morari, M; Motta, Z; Novellis, V; Nuzzo, T; Paolone, G; Pollegioni, L; Rosini, E; Sacchi, S; Squillace, M; Usiello, A	1
Hochman, E; Hollander, S; Krivoy, A; Selakovic, M; Sendt, KV; Taler, M; Vilner, Y; Weizman, A	1
Demjaha, A	1
Harrison, PJ	1
Aggarwal, S; Kim, HW; Millar, RP; Sing, K; Tang, C; Tello, JA	1
Fukuyama, K; Kato, R; Murata, M; Okada, M; Shiroyama, T	1
Fukuyama, K; Murata, M; Okada, M; Okubo, R; Shiroyama, T	1
Brown, EE; Caravaggio, F; Chakravarty, MM; Chan, N; Gerretsen, P; Graff-Guerrero, A; Hahn, M; Iwata, Y; Kim, J; Nakajima, S; Plitman, E; Remington, G; Shah, P; Torres, E	1
Chen, T; Chu, YX; Cui, WQ; Li, Q; Mao-Ying, QL; Mi, WL; Wang, YQ; Xu, F; Zhang, WW	1
Drozd, US; Dygalo, NN; Komysheva, NP; Lanshakov, DA; Shaburova, EV; Shishkina, GT; Sukhareva, EV	1
Bhattiprolu, AK; Brzustowicz, LM; Clarke, SG; Crosta, CM; Dudzinski, NR; Firestein, BL; Fu, AY; Hernandez, K; Moore, JC; Paradiso, KG	1
Avila, A; Barker, GJ; Borgan, F; Chang, N; Egerton, A; Ferreira, D; Gillespie, A; Howes, OD; Lally, J; Lythgoe, DJ; MacCabe, JH; McGuire, P; McQueen, G; Sendt, KV; Stone, JM; Vallianatou, K	1
Akkouh, IA; Andreassen, OA; Budinska, E; Djurovic, S; Grabiec, M; Hribkova, H; Kasparek, T; Sun, YM; Szabo, A	1
Bellaver, B; da Costa, JC; Fontana, IC; Fontella, FU; Greggio, S; Machado, LS; Miron, D; Pellerin, L; Rocha, A; Rosa-Neto, P; Schiavenin, ML; Schu, G; Souza, DG; Souza, DO; Venturin, GT; Zimmer, ER	1
Bell, RL; Burke, AR; Engleman, EA; Hauser, SR; Molosh, AI; Rodd, ZA; Truitt, WA	1
Al-Onaizi, M; Dover, B; Hogan-Cann, AE; Kljakic, O; Prado, MAM; Prado, VF; Yang, H	1
Arbelo, N; García-Rizo, C; Gassó, P; Gómez, M; Madero, S; Martínez-Pinteño, A; Mas, S; Morén, C; Parellada, E; Rodríguez, N; Treder, N	1
García-Rizo, C; Gassó, P; Gómez, M; Madero, S; Martínez-Pinteño, A; Mas, S; Morén, C; Parellada, E; Rodríguez, N; Segura, AG	1
Bastiampillai, T; Chan, SKW; Gregory, KJ; Langmead, CJ; Nair, PC; Tibrewal, P	1

Reviews

8 review(s) available for glutamic acid and clozapine

Article	Year
Cognitive function in schizophrenic patients. The Journal of clinical psychiatry, 1996, Volume: 57 Suppl 11 Topics: Antipsychotic Agents; Benzodiazepines; Cerebral Cortex; Clozapine; Cognition Disorders; Dopamine; Glutamic Acid; Humans; Limbic System; Olanzapine; Pirenzepine; Schizophrenia; Schizophrenic Psychology; Serotonin	1996
Cognitive deficit in schizophrenia and its neurochemical basis. The British journal of psychiatry. Supplement, 1999, Issue:37 Topics: Antipsychotic Agents; Benzodiazepines; Clozapine; Cognition Disorders; Glutamic Acid; Haloperidol; Humans; N-Methylaspartate; Olanzapine; Pirenzepine; Risperidone; Schizophrenia; Schizophrenic Psychology	1999
[Treatment of non-dopamine-dependent signs in parkinsonian syndromes: evaluation and results]. Revue neurologique, 2003, Volume: 159, Issue:5 Pt 2 Topics: Anti-Dyskinesia Agents; Botulinum Toxins; Cholinesterase Inhibitors; Clozapine; Dementia; Depressive Disorder; Dopamine; Glutamic Acid; Humans; Movement Disorders; Parkinsonian Disorders; Selective Serotonin Reuptake Inhibitors; Serotonin; Synaptic Transmission; Treatment Outcome	2003
Is the glycine site half saturated or half unsaturated? Effects of glutamatergic drugs in schizophrenia patients. Current opinion in psychiatry, 2006, Volume: 19, Issue:2 Topics: Antimetabolites; Antipsychotic Agents; Clozapine; Cycloserine; Drug Therapy, Combination; Glutamic Acid; Glycine; Humans; Receptors, N-Methyl-D-Aspartate; Sarcosine; Schizophrenia	2006
Animal models and treatments for addiction and depression co-morbidity. Neurotoxicity research, 2007, Volume: 11, Issue:1 Topics: Adrenergic Uptake Inhibitors; Animals; Antipsychotic Agents; Central Nervous System Stimulants; Clozapine; Depressive Disorder; Dopamine Agents; Glutamic Acid; Humans; Norepinephrine; Selective Serotonin Reuptake Inhibitors; Substance Withdrawal Syndrome; Substance-Related Disorders	2007
Topiramate in schizophrenia: a review of effects on psychopathology and metabolic parameters. Clinical schizophrenia & related psychoses, 2013, Volume: 6, Issue:4 Topics: Anticonvulsants; Antipsychotic Agents; Clozapine; Drug Therapy, Combination; Fructose; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Metabolic Diseases; Neuropsychological Tests; Schizophrenia; Schizophrenic Psychology; Topiramate; Weight Gain	2013
Clozapine augmented with glutamate modulators in refractory schizophrenia: a review and metaanalysis. Pharmacopsychiatry, 2014, Volume: 47, Issue:6 Topics: Animals; Antipsychotic Agents; Clozapine; Drug Synergism; Excitatory Amino Acid Agents; Glutamic Acid; Humans; Schizophrenia	2014
The glutamate hypothesis: a pathogenic pathway from which pharmacological interventions have emerged. Pharmacopsychiatry, 2014, Volume: 47, Issue:4-5 Topics: Clozapine; Drug Delivery Systems; Drug Therapy, Combination; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Memantine; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Schizophrenia	2014

Trials

1 trial(s) available for glutamic acid and clozapine

Article	Year
Plasma concentrations of amino acids in chronic schizophrenics treated with clozapine. Neuropsychobiology, 2001, Volume: 44, Issue:4 Topics: Adult; Amino Acids; Amino Acids, Neutral; Clozapine; Female; Follow-Up Studies; Glutamic Acid; Humans; Male; Reference Values; Schizophrenia	2001

Other Studies

72 other study(ies) available for glutamic acid and clozapine

Article	Year
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization. Journal of medicinal chemistry, 2005, Nov-03, Volume: 48, Issue:22 Topics: Adenine; Adenosine A2 Receptor Antagonists; Animals; Cell Line; Cricetinae; Cricetulus; Drug Design; Humans; Imidazoles; Male; Models, Molecular; Motor Activity; Purines; Radioligand Assay; Rats; Rats, Inbred F344; Structure-Activity Relationship; Triazoles	2005
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: de Bioorganic & medicinal chemistry, 2010, Nov-01, Volume: 18, Issue:21 Topics: Analgesics; Animals; Benzimidazoles; Drug Design; Drug Evaluation, Preclinical; Humans; Microsomes, Liver; Neuralgia; Nociceptin Receptor; Pyrroles; Rats; Receptors, Opioid; Structure-Activity Relationship	2010
Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties. Journal of medicinal chemistry, 2013, Feb-14, Volume: 56, Issue:3 Topics: Azepines; Biological Availability; Cognition; Drug Design; HEK293 Cells; Humans; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Serotonin Receptor Agonists	2013
Direct effect of neuroleptics on glutamate release. Neuropharmacology, 1984, Volume: 23, Issue:11 Topics: Amygdala; Animals; Antipsychotic Agents; Atropine; Avoidance Learning; Butaclamol; Calcium; Chlorpromazine; Clozapine; Glutamates; Glutamic Acid; Glutamine; Haloperidol; In Vitro Techniques; Male; Rats; Synaptosomes	1984
A comparison of the effects of acute and one year's continuous neuroleptic treatment on the release of [3H]glutamate and [3H]acetylcholine from rat striatal slices. Neuroscience, 1984, Volume: 11, Issue:1 Topics: Acetylcholine; Animals; Antipsychotic Agents; Calcium; Clozapine; Corpus Striatum; Dopamine; Glutamates; Glutamic Acid; Haloperidol; In Vitro Techniques; Male; Potassium; Rats; Rats, Inbred Strains; Sulpiride; Trifluoperazine	1984
Chronic haloperidol, but not clozapine, produces altered oral movements and increased extracellular glutamate in rats. European journal of pharmacology, 1994, Oct-03, Volume: 263, Issue:3 Topics: Administration, Oral; Analysis of Variance; Animals; Behavior, Animal; Clozapine; Corpus Striatum; Electric Stimulation; Female; Fourier Analysis; gamma-Aminobutyric Acid; Glutamic Acid; Haloperidol; Image Processing, Computer-Assisted; Microdialysis; Motor Activity; Rats; Rats, Sprague-Dawley	1994
Anti-glutamatergic effects of clozapine. Neuroscience letters, 1993, Dec-12, Volume: 163, Issue:2 Topics: Animals; Binding, Competitive; Cerebral Cortex; Clozapine; Corpus Striatum; Dizocilpine Maleate; Dopamine; Electric Stimulation; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Haloperidol; Humans; Membrane Potentials; Rats; Vibrissae	1993
Differential effects of chronic antipsychotic drug treatment on extracellular glutamate and dopamine concentrations. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1994, Volume: 14, Issue:7 Topics: Animals; Antipsychotic Agents; Caudate Nucleus; Clozapine; Dopamine; Extracellular Space; Glutamates; Glutamic Acid; Haloperidol; Male; Microdialysis; Nucleus Accumbens; Osmolar Concentration; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Time Factors	1994
Nicotine induced c-fos expression in the striatum is mediated mostly by dopamine D1 receptor and is dependent on NMDA stimulation. Brain research. Molecular brain research, 1994, Volume: 23, Issue:1-2 Topics: Animals; Benzamides; Benzazepines; Clozapine; Corpus Striatum; Dizocilpine Maleate; Gene Expression Regulation; Genes, fos; Glutamates; Glutamic Acid; Male; Mecamylamine; Nicotine; Nucleus Accumbens; Piperazines; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Reward	1994
Actions of clozapine and haloperidol on the extracellular levels of excitatory amino acids in the prefrontal cortex and striatum of conscious rats. Neuroscience letters, 1993, Apr-02, Volume: 152, Issue:1-2 Topics: Animals; Aspartic Acid; Clozapine; Corpus Striatum; Frontal Lobe; Glutamates; Glutamic Acid; Haloperidol; Male; Rats; Rats, Sprague-Dawley	1993
Glutamate agonist activity: implications for antipsychotic drug action and schizophrenia. Neuroreport, 1995, Dec-15, Volume: 6, Issue:18 Topics: Animals; Antipsychotic Agents; Clozapine; Dose-Response Relationship, Drug; Glutamic Acid; Glycine; Haloperidol; Male; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Schizophrenia	1995
Effects of subchronic clozapine and haloperidol on striatal glutamatergic synapses. Journal of neurochemistry, 1996, Volume: 67, Issue:5 Topics: Alternative Splicing; Animals; Base Sequence; Clozapine; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Administration Schedule; Genetic Variation; Glutamic Acid; Haloperidol; In Situ Hybridization; Ion Channels; Macromolecular Substances; Male; Microscopy, Immunoelectron; Nerve Endings; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; RNA Probes; Synapses	1996
Clozapine treatment increases serum glutamate and aspartate compared to conventional neuroleptics. Journal of neural transmission (Vienna, Austria : 1996), 1997, Volume: 104, Issue:6-7 Topics: Adult; Antipsychotic Agents; Aspartic Acid; Clozapine; Female; Glutamic Acid; Humans; Linear Models; Male; Middle Aged; Schizophrenia	1997
Mice with reduced NMDA receptor expression display behaviors related to schizophrenia. Cell, 1999, Aug-20, Volume: 98, Issue:4 Topics: Animals; Antipsychotic Agents; Antisocial Personality Disorder; Behavior, Animal; Calcium Signaling; Clozapine; Disease Models, Animal; Dizocilpine Maleate; Dopamine Antagonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Haloperidol; Male; Mice; Mice, Knockout; Motor Activity; Phencyclidine; Receptors, N-Methyl-D-Aspartate; Schizophrenic Psychology; Serotonin Antagonists; Sexual Behavior, Animal; Social Behavior; Stereotyped Behavior	1999
Differential effects of haloperidol and clozapine on ionotropic glutamate receptors in rats. Synapse (New York, N.Y.), 1999, Dec-15, Volume: 34, Issue:4 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Aspartic Acid; Binding Sites; Brain; Clozapine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Haloperidol; Kainic Acid; Male; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate	1999
Effect of benzodiazepines on the epithelial and neuronal high-affinity glutamate transporter EAAC1. Journal of neurochemistry, 1999, Volume: 73, Issue:6 Topics: Amino Acid Transport System X-AG; Animals; Anti-Anxiety Agents; Binding Sites; Carrier Proteins; CHO Cells; Clozapine; Cricetinae; Cricetulus; Diazepam; Epithelial Cells; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Ion Transport; Lorazepam; Medazepam; Nerve Tissue Proteins; Neurons; Oocytes; Oxazepam; Recombinant Fusion Proteins; Sodium; Symporters; Xenopus laevis	1999
Electrophysiological characterization of laminar synaptic inputs to the olfactory tubercle of the rat studied in vitro: modulation of glutamatergic transmission by cholinergic agents is pathway-specific. The European journal of neuroscience, 2001, Volume: 13, Issue:9 Topics: Animals; Barium; Cholinergic Agonists; Cholinergic Antagonists; Cholinesterase Inhibitors; Clozapine; Electric Stimulation; Evoked Potentials; GABA Antagonists; Glutamic Acid; Neural Pathways; Neurons; Olfactory Pathways; Organ Culture Techniques; Rats; Synapses; Synaptic Transmission	2001
The expression of glutamate transporter GLT-1 in the rat cerebral cortex is down-regulated by the antipsychotic drug clozapine. Molecular psychiatry, 2001, Volume: 6, Issue:4 Topics: Amino Acid Transport System X-AG; Animals; Antipsychotic Agents; ATP-Binding Cassette Transporters; Cerebral Cortex; Clozapine; Female; Frontal Lobe; Gene Expression Regulation; Glutamic Acid; In Vitro Techniques; Microdialysis; Oocytes; Rats; Rats, Sprague-Dawley; Recombinant Proteins; RNA, Messenger; Xenopus laevis	2001
Dopamine D4 receptor activation inhibits presynaptically glutamatergic neurotransmission in the rat supraoptic nucleus. Journal of neurophysiology, 2001, Volume: 86, Issue:3 Topics: Animals; Benzamides; Benzazepines; Clozapine; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamic Acid; Male; Patch-Clamp Techniques; Piperazines; Presynaptic Terminals; Pyridines; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D4; Sulpiride; Supraoptic Nucleus; Synaptic Transmission	2001
Effect of clozapine, haloperidol, or M100907 on phencyclidine-activated glutamate efflux in the prefrontal cortex. Biological psychiatry, 2001, Nov-15, Volume: 50, Issue:10 Topics: Animals; Clozapine; Fluorobenzenes; Glutamic Acid; Haloperidol; Male; Microdialysis; Phencyclidine; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Serotonin Antagonists	2001
A behavioural pattern analysis of hypoglutamatergic mice--effects of four different antipsychotic agents. Journal of neural transmission (Vienna, Austria : 1996), 2001, Volume: 108, Issue:10 Topics: Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Dizocilpine Maleate; Dopamine Antagonists; Drug Combinations; Excitatory Amino Acid Antagonists; Fluorobenzenes; Glutamic Acid; Haloperidol; Injections, Intraperitoneal; Male; Mice; Motor Activity; Piperidines; Risperidone; Serotonin Antagonists	2001
Interaction of dopamine D1 and NMDA receptors mediates acute clozapine potentiation of glutamate EPSPs in rat prefrontal cortex. Journal of neurophysiology, 2002, Volume: 87, Issue:5 Topics: Action Potentials; Animals; Benzazepines; Bupropion; Clozapine; Dopamine Antagonists; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Electric Stimulation; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamic Acid; Male; Membrane Glycoproteins; Membrane Transport Modulators; Membrane Transport Proteins; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate	2002
Differential effects of chronic haloperidol and clozapine administration on glutamatergic transmission in the fronto-parietal cortex in rats: microdialysis and electrophysiological studies. Naunyn-Schmiedeberg's archives of pharmacology, 2002, Volume: 366, Issue:5 Topics: Animals; Aspartic Acid; Clozapine; Electrophysiology; Frontal Lobe; Glutamic Acid; Haloperidol; Male; Microdialysis; Parietal Lobe; Rats; Rats, Wistar	2002
Clozapine-induced reduction of glutamate transport in the frontal cortex is not mediated by GLAST and EAAC1. Molecular psychiatry, 2003, Volume: 8, Issue:1 Topics: Amino Acid Transport System X-AG; Animals; Antipsychotic Agents; Clozapine; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 3; Frontal Lobe; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Rats; Symporters	2003
Modulation of the ability of clozapine to facilitate NMDA- and electrically evoked responses in pyramidal cells of the rat medial prefrontal cortex by dopamine: pharmacological evidence. The European journal of neuroscience, 2003, Volume: 17, Issue:6 Topics: 5-Hydroxytryptophan; alpha-Methyltyrosine; Animals; Antipsychotic Agents; Benzazepines; Clozapine; Dopamine; Dopamine Agents; Dopamine Antagonists; Electric Stimulation; Electrophysiology; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Levodopa; Male; N-Methylaspartate; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Reserpine; Synaptic Transmission; Tyrosine 3-Monooxygenase	2003
Effects of NRA0045, a novel potent antagonist at dopamine D4, 5-HT2A, and alpha1 adrenaline receptors, and NRA0160, a selective D4 receptor antagonist, on phencyclidine-induced behavior and glutamate release in rats. Psychopharmacology, 2003, Volume: 169, Issue:3-4 Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Chromatography, High Pressure Liquid; Clozapine; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Glutamic Acid; Haloperidol; Male; Microdialysis; Motor Activity; Phencyclidine; Piperidines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D4; Serotonin 5-HT2 Receptor Antagonists; Serotonin Antagonists; Stereotyped Behavior; Thiazoles; Time Factors	2003
Decoding schizophrenia. Scientific American, 2004, Volume: 290, Issue:1 Topics: Antipsychotic Agents; Brain; Clozapine; Dopamine; Glutamic Acid; Humans; Neurotransmitter Agents; Perception; Phencyclidine; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Signal Transduction	2004
Effects of haloperidol and clozapine on glutamate release from nerve terminals isolated from rat prefrontal cortex. Synapse (New York, N.Y.), 2005, Volume: 56, Issue:1 Topics: Animals; Clozapine; Dose-Response Relationship, Drug; Glutamic Acid; Haloperidol; Male; Prefrontal Cortex; Presynaptic Terminals; Rats; Rats, Sprague-Dawley	2005
Activation of noradrenergic locus coeruleus neurons by clozapine and haloperidol: involvement of glutamatergic mechanisms. The international journal of neuropsychopharmacology, 2005, Volume: 8, Issue:3 Topics: Action Potentials; Analysis of Variance; Animals; Antipsychotic Agents; Butyrates; Clozapine; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Haloperidol; Kynurenic Acid; Locus Coeruleus; Male; Neurons; Norepinephrine; Quinolones; Rats; Rats, Sprague-Dawley	2005
Clozapine reduces GLT-1 expression and glutamate uptake in astrocyte cultures. Glia, 2005, Volume: 50, Issue:3 Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; Antipsychotic Agents; Astrocytes; Cells, Cultured; Cerebral Cortex; Clozapine; Dose-Response Relationship, Drug; Down-Regulation; Excitatory Amino Acid Transporter 1; Excitatory Amino Acid Transporter 2; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Rats; Rats, Sprague-Dawley; Schizophrenia; Symporters; Synaptic Transmission	2005
Combined alpha2 and D2/3 receptor blockade enhances cortical glutamatergic transmission and reverses cognitive impairment in the rat. The international journal of neuropsychopharmacology, 2005, Volume: 8, Issue:3 Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Cerebral Cortex; Clozapine; Cognition Disorders; Disease Models, Animal; Dizocilpine Maleate; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Idazoxan; In Vitro Techniques; Male; Maze Learning; Raclopride; Radioligand Assay; Rats; Rats, Sprague-Dawley; Rats, Wistar; Synaptic Transmission	2005
Differential effects of clozapine and haloperidol on interval timing in the supraseconds range. Psychopharmacology, 2005, Volume: 182, Issue:2 Topics: Animals; Antipsychotic Agents; Clozapine; Dopamine; Dose-Response Relationship, Drug; Glutamic Acid; Haloperidol; Male; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Serotonin; Time Perception	2005
Expression of excitatory amino acid transporter interacting protein transcripts in the thalamus in schizophrenia. Synapse (New York, N.Y.), 2006, Jun-01, Volume: 59, Issue:7 Topics: Aged; Aged, 80 and over; Animals; Antipsychotic Agents; Clozapine; COP9 Signalosome Complex; Female; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Guanine Nucleotide Exchange Factors; Haloperidol; Heat-Shock Proteins; Humans; Image Processing, Computer-Assisted; In Situ Hybridization; Intracellular Signaling Peptides and Proteins; Male; Membrane Transport Proteins; Middle Aged; Rats; Rats, Sprague-Dawley; Rho Guanine Nucleotide Exchange Factors; RNA, Messenger; Schizophrenia; Thalamus; Transcription, Genetic	2006
Inhibition of the glycine transporter GlyT-1 potentiates the effect of risperidone, but not clozapine, on glutamatergic transmission in the rat medial prefrontal cortex. Synapse (New York, N.Y.), 2006, Volume: 60, Issue:2 Topics: Animals; Biological Transport, Active; Clozapine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamic Acid; Glycine; Glycine Plasma Membrane Transport Proteins; Male; Organ Culture Techniques; Prefrontal Cortex; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Risperidone; Sarcosine; Synaptic Transmission	2006
Role of the simultaneous enhancement of NMDA and dopamine D1 receptor-mediated neurotransmission in the effects of clozapine on phencyclidine-induced acute increases in glutamate levels in the rat medial prefrontal cortex. Naunyn-Schmiedeberg's archives of pharmacology, 2006, Volume: 374, Issue:3 Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Dose-Response Relationship, Drug; Drug Resistance; Glutamic Acid; Haloperidol; Humans; Male; Microdialysis; Motor Activity; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Schizophrenia	2006
Towards understanding the schizophrenia code: an expanded convergent functional genomics approach. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2007, Mar-05, Volume: 144B, Issue:2 Topics: Animals; Behavior, Animal; Biomarkers; Clozapine; gamma-Aminobutyric Acid; Gene Expression Regulation; Genetic Linkage; Genomics; Glutamic Acid; Humans; Male; Mice; Mice, Inbred C57BL; Myelin Sheath; Neurotransmitter Agents; Phencyclidine; Reproducibility of Results; Schizophrenia	2007
Clozapine and haloperidol differently suppress the MK-801-increased glutamatergic and serotonergic transmission in the medial prefrontal cortex of the rat. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:10 Topics: Animals; Antipsychotic Agents; Clozapine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Extracellular Fluid; gamma-Aminobutyric Acid; Glutamic Acid; Haloperidol; Male; Microdialysis; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, AMPA; Schizophrenia; Serotonin; Synaptic Transmission	2007
Different effects of a single and repeated administration of clozapine on phencyclidine-induced hyperlocomotion and glutamate releases in the rat medial prefrontal cortex at short- and long-term withdrawal from this antipsychotic. Naunyn-Schmiedeberg's archives of pharmacology, 2007, Volume: 375, Issue:4 Topics: Amphetamines; Animals; Antipsychotic Agents; Clozapine; Glutamic Acid; Male; Motor Activity; Phencyclidine; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate	2007
(+/-) Ketamine-induced prepulse inhibition deficits of an acoustic startle response in rats are not reversed by antipsychotics. Journal of psychopharmacology (Oxford, England), 2007, Volume: 21, Issue:3 Topics: Animals; Antipsychotic Agents; Clozapine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Haloperidol; Ketamine; Lamotrigine; Male; Pyridines; Rats; Rats, Sprague-Dawley; Reflex, Startle; Risperidone; Schizophrenia; Sulfonamides; Thiophenes; Triazines	2007
Glutaminase-deficient mice display hippocampal hypoactivity, insensitivity to pro-psychotic drugs and potentiated latent inhibition: relevance to schizophrenia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:10 Topics: Acoustic Stimulation; Amphetamine; Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Central Nervous System Stimulants; Clozapine; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Exploratory Behavior; Freezing Reaction, Cataleptic; Glutamic Acid; Glutaminase; Hippocampus; Image Processing, Computer-Assisted; Inhibition, Psychological; Ketamine; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Maze Learning; Memory, Short-Term; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Motor Activity; Oxygen; Protons; Reflex, Startle; Synaptic Transmission	2009
Differential effects of topiramate on prefrontal glutamatergic transmission when combined with raclopride or clozapine. Synapse (New York, N.Y.), 2009, Volume: 63, Issue:10 Topics: Animals; Biophysical Phenomena; Clozapine; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Excitatory Postsynaptic Potentials; Fructose; Glutamic Acid; In Vitro Techniques; Male; Membrane Potentials; N-Methylaspartate; Neuroprotective Agents; Patch-Clamp Techniques; Prefrontal Cortex; Pyramidal Cells; Raclopride; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Synaptic Transmission; Topiramate	2009
Sertindole restores attentional performance and suppresses glutamate release induced by the NMDA receptor antagonist CPP. Psychopharmacology, 2011, Volume: 214, Issue:3 Topics: Analysis of Variance; Animals; Antipsychotic Agents; Attention; Behavior, Animal; Choice Behavior; Clozapine; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Glutamic Acid; Imidazoles; Indoles; Male; Microdialysis; Neuropsychological Tests; Photic Stimulation; Piperazines; Rats; Rats, Sprague-Dawley; Reaction Time	2011
Long term antipsychotic treatment does not alter metabolite concentrations in rat striatum: an in vivo magnetic resonance spectroscopy study. Schizophrenia research, 2011, Volume: 128, Issue:1-3 Topics: Analysis of Variance; Animals; Antipsychotic Agents; Aspartic Acid; Choline; Clozapine; Corpus Striatum; Creatine; Dose-Response Relationship, Drug; Glutamic Acid; Haloperidol; Magnetic Resonance Spectroscopy; Male; Rats; Rats, Sprague-Dawley	2011
Clozapine, but not haloperidol, enhances glial D-serine and L-glutamate release in rat frontal cortex and primary cultured astrocytes. British journal of pharmacology, 2012, Volume: 165, Issue:5 Topics: Animals; Antipsychotic Agents; Astrocytes; Cells, Cultured; Citrates; Clozapine; Glutamic Acid; Haloperidol; Male; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serine; Tetanus Toxin; Tetrodotoxin	2012
Clozapine decreases exploratory activity and increases anxiety-like behaviour in the Wistar-Kyoto rat but not the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder. Brain research, 2012, Jul-27, Volume: 1467 Topics: Analysis of Variance; Animals; Antipsychotic Agents; Anxiety; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Clozapine; Exploratory Behavior; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Injections, Intraperitoneal; Male; Motor Activity; Norepinephrine; Potassium; Prefrontal Cortex; Rats; Rats, Inbred SHR; Rats, Inbred WKY	2012
Changes in plasma D-serine, L-serine, and glycine levels in treatment-resistant schizophrenia before and after clozapine treatment. Neuroscience letters, 2014, Oct-17, Volume: 582 Topics: Adult; Antipsychotic Agents; Case-Control Studies; Clozapine; Female; Glutamic Acid; Glutamine; Glycine; Humans; Male; Middle Aged; Schizophrenia; Serine; Stereoisomerism; Treatment Failure	2014
Involvement of glutamatergic and GABAergic transmission in MK-801-increased gamma band oscillation power in rat cortical electroencephalograms. Neuroscience, 2014, Nov-07, Volume: 280 Topics: Amino Acids; Animals; Antipsychotic Agents; Bridged Bicyclo Compounds, Heterocyclic; Cerebral Cortex; Clozapine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electrodes, Implanted; Electroencephalography; Excitatory Amino Acid Antagonists; Fluorobenzenes; GABA Agents; Gamma Rhythm; gamma-Aminobutyric Acid; Glutamic Acid; Haloperidol; Male; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Metabotropic Glutamate; Riluzole; Triazoles	2014
Glutamatergic neurometabolites in clozapine-responsive and -resistant schizophrenia. The international journal of neuropsychopharmacology, 2015, Jan-20, Volume: 18, Issue:6 Topics: Adult; Antipsychotic Agents; Biomarkers; Brain; Case-Control Studies; Clozapine; Creatine; Drug Resistance; Drug Therapy, Combination; Female; Glutamic Acid; Glutamine; Humans; Magnetic Resonance Imaging; Male; Proton Magnetic Resonance Spectroscopy; Schizophrenia; Schizophrenic Psychology; Treatment Outcome; Young Adult	2015
Gq-DREADD Selectively Initiates Glial Glutamate Release and Inhibits Cue-induced Cocaine Seeking. Biological psychiatry, 2015, Oct-01, Volume: 78, Issue:7 Topics: Animals; Astrocytes; Calcium Channels, N-Type; Central Nervous System Agents; Clozapine; Cocaine; Cocaine-Related Disorders; Cues; Dietary Sucrose; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Extinction, Psychological; Genetic Therapy; Glutamic Acid; Male; Mice, Transgenic; Nucleus Accumbens; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Metabotropic Glutamate; Self Administration; SNARE Proteins	2015
Higher serum concentrations of tyrosine and glutamate in schizophrenia patients treated with clozapine, compared to in those treated with conventional antipsychotics. Neuro endocrinology letters, 2015, Volume: 36, Issue:5 Topics: Adult; Amino Acids; Antipsychotic Agents; Chromatography, Ion Exchange; Clopenthixol; Clozapine; Cohort Studies; Female; Glutamic Acid; Haloperidol; Humans; Insulin Resistance; Male; Middle Aged; Perphenazine; Prospective Studies; Psychotic Disorders; Schizophrenia; Thioridazine; Tyrosine	2015
Disrupted Prediction Error Links Excessive Amygdala Activation to Excessive Fear. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, Jan-13, Volume: 36, Issue:2 Topics: Action Potentials; Amygdala; Animals; Clozapine; Conditioning, Operant; Conditioning, Psychological; Dependovirus; Electroshock; Extinction, Psychological; Fear; Glutamic Acid; Humans; Male; Membrane Potentials; Neurons; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M3; Receptors, Drug	2016
Trans-generation enrichment of clozapine-responsiveness trait in mice using a subchronic hypo-glutamatergic model of schizophrenia:A preliminary study. Behavioural brain research, 2017, 04-14, Volume: 323 Topics: Animals; Antipsychotic Agents; Clozapine; Disease Models, Animal; Female; Frontal Lobe; Glutamate Decarboxylase; Glutamic Acid; Hippocampus; Male; Mice; Mice, Inbred C57BL; Phencyclidine; Schizophrenia; Selective Breeding; Social Behavior	2017
Olanzapine, but not clozapine, increases glutamate release in the prefrontal cortex of freely moving mice by inhibiting D-aspartate oxidase activity. Scientific reports, 2017, 04-10, Volume: 7 Topics: Animals; Benzodiazepines; Clozapine; D-Aspartate Oxidase; Dose-Response Relationship, Drug; Enzyme Activation; Glutamic Acid; Humans; Male; Mice; Mice, Knockout; N-Methylaspartate; Olanzapine; Prefrontal Cortex; Receptors, N-Methyl-D-Aspartate; Selective Serotonin Reuptake Inhibitors	2017
Association between serum levels of glutamate and neurotrophic factors and response to clozapine treatment. Schizophrenia research, 2018, Volume: 192 Topics: Adult; Antipsychotic Agents; Clozapine; Cross-Sectional Studies; Enzyme-Linked Immunosorbent Assay; Female; Glutamic Acid; Humans; Male; Middle Aged; Nerve Growth Factors; Psychiatric Status Rating Scales; Schizophrenia; Statistics, Nonparametric	2018
On the brink of precision medicine for psychosis: Treating the patient, not the disease: A commentary on: Association between serum levels of glutamate and neurotrophic factors and response to clozapine treatment by Krivoy et al. 2017. Schizophrenia research, 2018, Volume: 193 Topics: Antipsychotic Agents; Clozapine; Glutamic Acid; Humans; Nerve Growth Factors; Precision Medicine; Psychotic Disorders; Schizophrenia	2018
D-Amino Acid Oxidase Inhibition: A New Glutamate Twist for Clozapine Augmentation in Schizophrenia? Biological psychiatry, 2018, 09-15, Volume: 84, Issue:6 Topics: Antipsychotic Agents; Clozapine; Double-Blind Method; Glutamic Acid; Humans; Oxidoreductases; Schizophrenia; Sodium Benzoate	2018
Medial Amygdala Kiss1 Neurons Mediate Female Pheromone Stimulation of Luteinizing Hormone in Male Mice. Neuroendocrinology, 2019, Volume: 108, Issue:3 Topics: Administration, Inhalation; Amygdala; Animals; Clozapine; gamma-Aminobutyric Acid; Glutamic Acid; Kisspeptins; Luteinizing Hormone; Male; Mice; Mice, Transgenic; Neurons; Pheromones; Preoptic Area; Vesicular Glutamate Transport Protein 2; Vesicular Inhibitory Amino Acid Transport Proteins	2019
Clozapine Normalizes a Glutamatergic Transmission Abnormality Induced by an Impaired NMDA Receptor in the Thalamocortical Pathway via the Activation of a Group III Metabotropic Glutamate Receptor. Biomolecules, 2019, 06-17, Volume: 9, Issue:6 Topics: Animals; Clozapine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Mediodorsal Thalamic Nucleus; Prefrontal Cortex; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission	2019
Activation of Astroglial Connexin is Involved in Concentration-Dependent Double-Edged Sword Clinical Action of Clozapine. Cells, 2020, 02-11, Volume: 9, Issue:2 Topics: Antipsychotic Agents; Astrocytes; Cell Membrane; Clozapine; Connexin 43; Glutamic Acid; Humans; Myocarditis; Schizophrenia; Serine; Valproic Acid	2020
Glutamatergic neurometabolites and cortical thickness in treatment-resistant schizophrenia: Implications for glutamate-mediated excitotoxicity. Journal of psychiatric research, 2020, Volume: 124 Topics: Antipsychotic Agents; Clozapine; Glutamic Acid; Humans; Magnetic Resonance Imaging; Proton Magnetic Resonance Spectroscopy; Schizophrenia	2020
Tacr3 in the lateral habenula differentially regulates orofacial allodynia and anxiety-like behaviors in a mouse model of trigeminal neuralgia. Acta neuropathologica communications, 2020, 04-07, Volume: 8, Issue:1 Topics: Animals; Antipsychotic Agents; Anxiety; Behavior, Animal; Clozapine; Disease Models, Animal; Elevated Plus Maze Test; Glutamic Acid; Habenula; Hyperalgesia; Maxillary Nerve; Mice; Neural Inhibition; Neurons; Open Field Test; Receptors, Neurokinin-3; Transcriptome; Trigeminal Neuralgia	2020
Chemogenetic Activation of Glutamatergic Neurons in the Juvenile Rat Cortex Reduces Anxiety. Doklady. Biochemistry and biophysics, 2020, Volume: 490, Issue:1 Topics: Animals; Anxiety; Behavior, Animal; Clozapine; Emotions; Female; Glutamic Acid; Glutamine; Male; Neurons; Prefrontal Cortex; Rats; Rats, Wistar	2020
Characterization hiPSC-derived neural progenitor cells and neurons to investigate the role of NOS1AP isoforms in human neuron dendritogenesis. Molecular and cellular neurosciences, 2020, Volume: 109 Topics: Adaptor Proteins, Signal Transducing; Cells, Cultured; Clozapine; Dendrites; Drug Evaluation, Preclinical; Fluphenazine; Gene Expression Regulation; Glutamic Acid; Haloperidol; Humans; Induced Pluripotent Stem Cells; Ion Channels; Nerve Tissue Proteins; Neural Stem Cells; Neurons; Oligopeptides; Patch-Clamp Techniques; Protein Isoforms; Schizophrenia; Serine	2020
Changes in Brain Glutamate on Switching to Clozapine in Treatment-Resistant Schizophrenia. Schizophrenia bulletin, 2021, 04-29, Volume: 47, Issue:3 Topics: Adult; Antipsychotic Agents; Caudate Nucleus; Clozapine; Female; Glutamic Acid; Glutamine; Gyrus Cinguli; Humans; Longitudinal Studies; Male; Middle Aged; Outcome Assessment, Health Care; Proton Magnetic Resonance Spectroscopy; Schizophrenia	2021
Derivation and Molecular Characterization of a Morphological Subpopulation of Human iPSC Astrocytes Reveal a Potential Role in Schizophrenia and Clozapine Response. Schizophrenia bulletin, 2022, 01-21, Volume: 48, Issue:1 Topics: Adult; Antipsychotic Agents; Astrocytes; Clozapine; Female; Glutamic Acid; Humans; Induced Pluripotent Stem Cells; Male; Middle Aged; Schizophrenia; Serine	2022
Clozapine induces astrocyte-dependent FDG-PET hypometabolism. European journal of nuclear medicine and molecular imaging, 2022, Volume: 49, Issue:7 Topics: Animals; Astrocytes; Clozapine; Fluorodeoxyglucose F18; Glucose; Glutamic Acid; Humans; Male; Positron-Emission Tomography; Rats; Rats, Wistar	2022
CNO Administration Increases Dopamine and Glutamate in the Medial Prefrontal Cortex of Wistar Rats: Further Concerns for the Validity of the CNO-activated DREADD Procedure. Neuroscience, 2022, 05-21, Volume: 491 Topics: Animals; Clozapine; Dopamine; Glutamic Acid; Prefrontal Cortex; Rats; Rats, Wistar	2022
Chemogenetic activation of VGLUT3-expressing neurons decreases movement. European journal of pharmacology, 2022, Nov-15, Volume: 935 Topics: Acetylcholine; Clozapine; Glutamic Acid; Neurons	2022
The Effect of Clozapine and Novel Glutamate Modulator JNJ-46356479 on Nitrosative Stress in a Postnatal Murine Ketamine Model of Schizophrenia. International journal of molecular sciences, 2023, Jan-05, Volume: 24, Issue:2 Topics: Adult; Animals; Clozapine; Glutamic Acid; Humans; Ketamine; Mice; Nitrosative Stress; Prefrontal Cortex; Receptors, N-Methyl-D-Aspartate; Schizophrenia	2023
Neurotoxic/Neuroprotective Effects of Clozapine and the Positive Allosteric Modulator of mGluR2 JNJ-46356479 in Human Neuroblastoma Cell Cultures. International journal of molecular sciences, 2023, Jan-20, Volume: 24, Issue:3 Topics: Adult; Allosteric Regulation; Animals; Caspase 3; Cell Culture Techniques; Clozapine; Glutamic Acid; Humans; Mice; Neuroblastoma; Neuroprotective Agents	2023
Does clozapine treat antipsychotic-induced behavioural supersensitivity through glutamate modulation within the striatum? Molecular psychiatry, 2023, Volume: 28, Issue:5 Topics: Antipsychotic Agents; Clozapine; Corpus Striatum; Glutamic Acid; Haloperidol	2023