glutamic acid has been researched along with capsaicin in 167 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (2.40) | 18.7374 |
| 1990's | 25 (14.97) | 18.2507 |
| 2000's | 71 (42.51) | 29.6817 |
| 2010's | 60 (35.93) | 24.3611 |
| 2020's | 7 (4.19) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Bogduk, N; Lambert, GA; Lance, JW; Zagami, AS | 1 |
| Jeftinija, K; Jeftinija, S; Larson, AA; Liu, F; Skilling, SR; Smullin, DH | 1 |
| Kangrga, I; Randić, M | 2 |
| Donnerer, J | 1 |
| Kangrga, I; Larew, JS; Randic, M | 1 |
| Bossut, D; Frenk, H; Mayer, DJ; Urca, G | 1 |
| Otsuka, M; Yanagisawa, M | 1 |
| Schmid, R; Singer, EA; Sperk, G | 1 |
| Ito, S; Ohga, A; Seno, N | 1 |
| Kuraishi, Y; Okano, K; Satoh, M | 1 |
| Kuraishi, Y; Satoh, M; Sugimoto, K; Ueda, M | 1 |
| Kuraishi, Y; Oyama, T; Satoh, M; Sugimoto, K; Ueda, M | 1 |
| Larson, AA; Skilling, SR | 1 |
| Akaike, A; Kuraishi, Y; Oyama, T; Satoh, M; Ueda, M | 1 |
| Ault, B; Hildebrand, LM | 1 |
| Kuraishi, Y; Satoh, M; Ueda, M | 1 |
| Bowery, NG; Fowler, LJ; Malcangio, M; Teoh, H | 1 |
| Abiko, Y; Hara, A; Kisara, K; Sakurada, C; Sakurada, S; Sakurada, T; Sugiyama, A; Tanno, K | 1 |
| Kuraishi, Y; Tohda, C | 1 |
| Dirig, DM; Hua, XY; Yaksh, TL | 1 |
| Juránek, I; Lembeck, F | 1 |
| Kuraishi, Y; Okano, K; Satoh, M; Ueda, M | 1 |
| Beirith, A; Calixto, JB; Creczynski-Pasa, TB; Rodrigues, AL; Santos, AR | 1 |
| Sluka, KA; Willis, WD | 1 |
| Kuraishi, Y; Sasaki, M; Sasamura, T; Tohda, C | 1 |
| Kuraishi, Y; Sasaki, M; Tohda, C | 1 |
| Ito, S; Minami, T | 1 |
| Calixto, JB; Ferreira, J; Santos, AR | 1 |
| Calixto, JB; Filho, VC; Malheiros, A; Mendes, GL; Santos, AR; Yunes, RA | 1 |
| Carlton, SM; deGroot, J; Zhou, S | 1 |
| Bedol, D; Dreshaj, IA; Ferguson, DG; Haxhiu, MA; Yamamoto, B | 1 |
| Cahill, CM; Coderre, TJ; Fisher, K; Lefebvre, C | 1 |
| Ito, S; Matsumura, S; Minami, T; Mishina, M; Mori, H; Okuda-Ashitaka, E; Sakimura, K; Shimamoto, K | 1 |
| Adelson, DW; Bradbury, EJ; Cunningham, JR; Jones, MG; Lever, IJ; Malcangio, M; Marvizón, JC; McMahon, SB | 1 |
| Morisset, V; Urban, L | 1 |
| Eisenach, JC; Li, X | 2 |
| Hökfelt, T; Kerekes, N; Rydh-Rinder, M; Svensson, M | 1 |
| Kawamata, M; Kawamata, T; Namiki, A; Omote, K; Toriyabe, M | 1 |
| Afrah, AW; Brodin, E; Gustafsson, H; Olgart, L; Stiller, CO | 1 |
| Liu, XJ; Sawynok, J; White, TD | 1 |
| Chen, J; Furue, H; Kumamoto, E; Luo, C; Yoshimura, M | 1 |
| Christie, MJ; Connor, M; Marinelli, S; Vaughan, CW | 1 |
| Beirith, A; Calixto, JB; Santos, AR | 1 |
| Baccei, ML; Bardoni, R; Fitzgerald, M | 1 |
| Bernardi, G; Berretta, N; Di Marzo, V; Maccarrone, M; Marinelli, S; Matias, I; Mercuri, NB | 1 |
| Gear, RW; Levine, JD; Tambeli, CH; Young, A | 1 |
| Köfalvi, A; Ledent, C; Sperlágh, B; Vizi, ES | 1 |
| Feldman, JL; Morgado-Valle, C | 1 |
| Okere, CO; Waterhouse, BD | 1 |
| Chen, SR; Li, DP; Pan, HL | 1 |
| Andresen, MC; Bailey, TW; Jin, YH; Li, BY; Schild, JH | 1 |
| Lähdesmäki, J; Mansikka, H; Pertovaara, A; Scheinin, M | 1 |
| Fujita, T; Kawasaki, Y; Kumamoto, E; Yue, HY | 1 |
| Burette, A; Hwang, SJ; Rustioni, A; Valtschanoff, JG | 1 |
| Fujita, T; Kamisaki, Y; Yonehara, N | 1 |
| Joseph, DJ; Labrakakis, C; Lee, CJ; Macdermott, AB | 1 |
| Donnerer, J; Liebmann, I; Lippe, IT; Schicho, R | 1 |
| Fang, L; Lei, Y; Willis, WD; Wu, J; Zhang, X | 1 |
| de Lago, E; Di Marzo, V; Fernández-Ruiz, J; Ramos, JA; Urbani, P | 1 |
| Facundo, VA; Marques, MC; Pietrovski, EF; Rios, K; Rosa, KA; Santos, AR | 1 |
| Fujita, T; Jin, YH; Nishioka, H; Wakabayashi, K; Yonehara, N | 1 |
| Capra, NF; Ro, JY | 1 |
| Li, J; Xing, J | 1 |
| Chen, SR; Pan, HL; Zhang, HM; Zhou, HY | 1 |
| Duan, Y; Nicholson, RA; Zheng, J | 1 |
| Ardenghi, JV; De Souza, MM; Filho, VC; Kanegusuku, M; Monache, FD; Niero, R; Yunes, RA | 1 |
| Chen, M; Gu, JG; Tao, YX | 1 |
| Fachinetto, R; Maffi, LC; Meotti, FC; Missau, FC; Pizzolatti, MG; Rocha, JB; Santos, AR | 1 |
| Jesse, CR; Nogueira, CW; Pinto, LG; Savegnago, L | 1 |
| Cristino, L; de Novellis, V; Di Marzo, V; Maione, S; Marabese, I; Palazzo, E; Rossi, F; Starowicz, K | 1 |
| Arendt-Nielsen, L; Cairns, BE; Sessle, BJ; Svensson, P; Wang, K | 2 |
| Cechinel Filho, V; de Souza, MM; Delle Monache, F; Delle Monache, G; Fischer, LG; Malheiros, A; Santos, D; Serafin, C | 1 |
| Chen, AD; De, W; Duan, YC; Gao, XY; Xu, B; Zhong, MK; Zhu, GQ | 1 |
| Kim, MS; Medvedeva, YV; Usachev, YM | 1 |
| de Souza, MM; Filho, AW; Filho, VC; Olinger, L | 1 |
| Gao, W; Geisslinger, G; Kuner, R; Luo, C; Schmidtko, A; Tegeder, I | 1 |
| Antunes, C; Böhmer, AE; Elisabetsky, E; Leke, R; Pereira, MS; Schallenberger, C; Schmidt, AP; Souza, DO; Wofchuk, ST | 1 |
| Andresen, MC; Peters, JH | 1 |
| Bernardi, G; Centonze, D; De Chiara, V; Maccarrone, M; Musella, A; Prosperetti, C; Rossi, S | 1 |
| Chen, H; Chen, SR; Pan, HL; Zhou, HY | 1 |
| Hu, JW; Lam, DK; Sessle, BJ | 2 |
| Avelino, A; Cruz, F; Cunha, RA; Ferreira, SG; Köfalvi, A; Lomaglio, T; Oliveira, CR | 1 |
| Antunes, C; Böhmer, AE; Elisabetsky, E; Lara, DR; Porciúncula, LO; Schallenberger, C; Schmidt, AP; Souza, DO | 1 |
| Arendt-Nielsen, L; Gibson, W; Graven-Nielsen, T; Sessle, BJ | 1 |
| Mense, S | 1 |
| Furuyama, A; Jin, YH; Koike, Y; Takemura, M; Yamaki, F; Yonehara, N | 1 |
| Brand, A; Landau, VJ; LaVinka, PC; Park, TJ; Wirtshafter, D | 1 |
| Cui, L; Kim, H; Kim, J; Kim, SJ | 1 |
| Cristino, L; de Novellis, V; Di Marzo, V; Guida, F; Luongo, L; Maione, S; Marabese, I; Palazzo, E; Rossi, F; Starowicz, K | 1 |
| Jean, A; Lebrun, B; Roux, J; Trouslard, J; Wanaverbecq, N | 1 |
| Ardenghi, JV; Bresciani, LF; Cechinel-Filho, V; De Souza, MM; Delle Monache, F; Mora, TC; Pereira, MA; Yunes, RA | 1 |
| Gregg, RG; Heimel, JA; Kamermans, M; Nawy, S; Peachey, NS; Shen, Y | 1 |
| Bang, SI; Jin, YH; Sun, B | 1 |
| Bortolatto, CF; Jesse, CR; Nogueira, CW; Savegnago, L; Wilhelm, EA | 1 |
| Cechinel-Filho, V; Corrêa, R; de Campos-Buzzi, F; Delle Monache, F; Fracasso, M; Niero, R; Padaratz, P | 1 |
| Davies, AJ; North, RA | 1 |
| Fujita, T; Jiang, CY; Kumamoto, E; Liu, T; Nakatsuka, T; Piao, LH; Yue, HY | 1 |
| Kondo, S; Matsumoto, M; Ueda, H; Usdin, TB | 1 |
| Barbanel, G; Cohen-Solal, C; Crouzin, N; Ferreira, MC; Guiramand, J; Vignes, M | 1 |
| Ghazi-Khansari, M; Jaberi, E; Mohammadi-Farani, A; Sahebgharani, M; Sepehrizadeh, Z | 1 |
| Andresen, MC; Fawley, JA; McDougall, SJ; Peters, JH; Smith, SM | 1 |
| Almeida, FR; Chaves, MH; Costa, DA; Figueiredo, KA; Lopes, LS; Marques, RB; Pereira, SS | 1 |
| Coderre, TJ; Kumar, N; Laferriere, A; Poon, T; Yu, JS | 1 |
| Bari, M; Battista, N; Bonanno, G; Bonifacino, T; Giribaldi, F; Maccarrone, M; Milanese, M; Spagnuolo, P; Usai, C; Zappettini, S | 1 |
| Akhtar, MN; Israf, DA; Khalid, MH; Khalid, S; Lajis, NH; Mohamad, AS; Mohd, PA; Perimal, EK; Sulaiman, MR; Zakaria, ZA | 1 |
| Andresen, MC; Fawley, JA; McDougall, SJ; Peters, JH; Shoudai, K | 1 |
| Abdel Samad, O; Duan, B; Ji, RR; Liu, Y; Lopes, C; Lowell, BB; Ma, Q; Tong, Q; Zhang, L | 1 |
| Cordeiro, MN; Ferreira, J; Gomez, MV; Gonçaves, JM; Junior, CJ; Pinheiro, AC; Prado, MA; Richardson, M; Silva, MA; Souza, AH | 1 |
| Choi, SY; Chun, GS; Davies, AJ; Hwang, SM; Jin, M; Kim, JS; Koo, NY; Park, K | 1 |
| Chiou, LC; Ho, YC; Lee, HJ; Liao, HT | 1 |
| Baptista, V; Browning, KN; Travagli, RA; Wan, S | 1 |
| Carlton, SM; Du, J; Govea, R; Zhou, S | 1 |
| Andresen, MC; Fawley, JA; McDougall, SJ; Peters, JH | 1 |
| Bum, EN; Dawe, A; De Waard, M; Dimo, T; Dzeufiet, PD; Nguimbou, RM; Sidiki, N; Taïwe, GS; Talla, E | 1 |
| Bagetta, G; Mizoguchi, H; Sakurada, S; Watanabe, C | 1 |
| Carroll, RC; Nawy, S; Rampino, MA; Shen, Y | 1 |
| Malmierca, E; Martin, YB; Nuñez, A | 1 |
| Jung, AY; Jung, KY; Lee, JG; Lin, C; Nam, SY; Yon, JM | 1 |
| Araujo, BS; Botelho, MA; Damascena, NP; Dias, AS; Estevam, CS; Lima, AC; Melo, MS; Oliveira, MG; Paixão, MS; Quintans, LJ; Santana, MT | 1 |
| Bazzo, KO; Campos, MM; Gomez, MV; Lopes, TG; Souto, AA; Souza, AH; Zanin, RF | 1 |
| Araújo, BS; Damascena, NP; de Lima, AC; de Santana, MT; Dias, AS; dos S Estevam, C; Fernandes, XA; Lima, CA; Melo, M; Paixão, MS; Porto, YC; Quintans Júnior, LJ; Santos, CC | 1 |
| Almeida, FR; Brandão, MS; Chaves, MH; Ferreira, EL; Lima, DF; Oliveira, JP; Pereira, SS | 1 |
| Cechinel Filho, V; de Campos Buzzi, F; Klein-Júnior, LC; Moreira, J | 1 |
| Du, JQ; Han, M; Li, Q; Liu, XH; Sun, N; Tang, JS; Zhu, JX | 1 |
| Santana, DG; Santos, CA; Santos, DS; Thomazzi, SM | 1 |
| da Silva-Santos, CS; Ferreira, SG; Garção, P; Köfalvi, A; Köles, L; Ledent, C; Pinheiro, BS; Zádori, ZS | 1 |
| Alves, PB; Araújo, AA; Bonjardim, LR; de Lucca Júnior, W; Lucchese, AM; Menezes, PP; Quintans, JS; Quintans-Júnior, LJ; Santos, MR; Siqueira-Lima, PS | 1 |
| Hamzah, AS; Kek, TL; Mansor, NS; Mohammat, MF; Salleh, MZ; Sani, MH; Shaameri, Z; Zakaria, ZA | 1 |
| Almeida, AF; Almeida, EC; Araujo, BS; Cunha, RS; Curvello, RL; Damascena, NP; Dias, AS; Estevam, CS; Lima, AC; Paixão, MS; Quintans Júnior, LJ; Santos, CC; Souza, LM; Souza, MT | 1 |
| Almeida, FR; Amaral, MP; Chaves, MH; Costa, DA; Figueiredo, KA; Júnior, FB; Oliveira, FA; Oliveira, IS; Oliveira, RC; Silva, FV | 1 |
| Boylan, F; Dias Fernandes, P; Miltojević, AB; Pinheiro, MM; Radulović, NS | 1 |
| Andresen, T; Arendt-Nielsen, L; Drewes, AM; Lassen, D; Nielsen, AK; Nilsson, M | 1 |
| Ganev, EG; Hiruma-Lima, CA; Martins, DF; Mazzardo-Martins, L; Nishijima, CM; Rocha, LR; Santos, AR | 1 |
| Andresen, MC; Fawley, JA; Hofmann, ME | 1 |
| Binda, N; Castro, CJ; Cordeiro, MN; da Silva, JF; de Souza, AH; Diniz, DM; Ferreira, J; Gomez, MV; Pereira, EM; Rigo, FK; Romano-Silva, MA | 1 |
| Fujita, T; Jiang, CY; Kumamoto, E; Luo, QT | 1 |
| Guindon, J; Lin, JS | 1 |
| Kek, TL; Salleh, MZ; Sani, MH; Susanti, D; Taher, M; Zakaria, ZA | 1 |
| Fazzari, J; Lin, H; Murphy, C; Singh, G; Ungard, R | 1 |
| Fujita, T; Jiang, CY; Kang, Q; Kumamoto, E | 1 |
| Eisenach, JC; Hayashida, K; Kimura, M; Suto, T | 1 |
| Andresen, MC; Hofmann, ME | 1 |
| Yang, K | 1 |
| Awouafack, MD; Kamanyi, A; Nguelefack, TB; Nkeng-Efouet, PA; Tatsinkou Bomba, FD; Wandji, BA | 1 |
| Endo, Y; Nemoto, W; Shima, K; Sugawara, S; Takano-Yamamoto, T; Tan-No, K; Tsuchiya, M | 1 |
| Aktumsek, A; Amarante, RKL; Amarante, RS; Barreto, AS; Barreto, RSS; Coutinho, HDM; Duarte, MC; Menezes, IRA; Nascimento, TS; Pereira, EWM; Quintans, JSS; Quintans-Júnior, LJ; Zengin, G | 1 |
| Akhtar, MN; Akira, A; Ismail, NI; Israf, DA; Lajis, N; Ming-Tatt, L; Perimal, EK; Sulaiman, MR | 1 |
| Fujita, T; Kumamoto, E; Piao, LH; Yu, T | 1 |
| Gao, G; Heng, L; Jia, D; Qu, L; Song, J; Wang, X; Wang, Y; Zhang, H | 1 |
| Braga, RM; de Almeida, RN; de Castro, RD; de Sousa, DP; de Sousa, FB; deM Pordeus, LC; Tomaz-Morais, JF | 1 |
| Cheng, G; Huang, M; Qin, R; Tan, H; Wang, Y; Zhang, Y; Zou, Y | 1 |
| Barbosa, TM; Barroso, LKV; Batista, FLA; Campos, AR; da Silva, ARA; Damasceno, MBMV; de Melo, JMA; de Oliveira, BA; Guedes, MIF; Holanda, DKR; Lima, MDCL; Magalhães, FEA; Moura, LFWG; Nogueira, AB; Santos, SAAR; Serpa, OF | 1 |
| Fernandes, PD; Giorno, TBS; Moreira, IGDS; Rezende, CM | 1 |
| Andrade Próspero, DF; de Castro Almeida, FR; de Sousa, DP; Lopes, EM; Piauilino, CA; Reis Filho, AC | 1 |
| Brito, BM; Gobira, PH; Joca, SRL; Sartim, AG | 1 |
| Binda, NS; Borges, MH; Carobin, NV; Castro Junior, CJ; Ferreira, J; Gomez, MV; Kushmerick, C; Pinto Nagem, RA; Ribeiro, FM; Rita Pereira, EM; Santos, DC; Silva Júnior, CA; Silva, JF; Souza, JM | 1 |
| Antunes, FTT; Caminski, ES; Dallegrave, E; de Freitas, LM; de Souza, AH; Gomez, MV; Junior, CADS; Pereira, EMR | 1 |
| Antero, LS; Borges-Assis, AB; Lisboa, SF; Resstel, LB; Rosa, J; Uliana, DL; Vila-Verde, C | 1 |
| Brüning, T; Bünger, J; Heba, S; Schmidt-Wilcke, T; Sczesny-Kaiser, M; Sucker, K; Tegenthoff, M | 1 |
| Bang, SK; Cho, SJ; Choi, KH; Kang, SY; Ryu, Y; Seo, SY | 1 |
| Capim, SL; Carvalho, VAN; Côrtes, WDS; de Carvalho Cid, G; Fernandes, TFDC; Gonçalves, GM; Laureano-Melo, R; Marinho, BG; Oliveira, JM; Vasconcellos, MLAA | 1 |
| Almeida, RN; Braga, RM; Castro, RD; Costa, TKVLD; Dantas, NV; Limeira, RRT; Salvadori, MGDSS; Scotti, L; Sousa, FB; Tomaz-Morais, JF | 1 |
1 review(s) available for glutamic acid and capsaicin
| Article | Year |
|---|---|
[Biochemistry of pain].
Topics: Afferent Pathways; Animals; Capsaicin; Glutamic Acid; Humans; Narcotics; Nerve Growth Factors; Neurons, Afferent; Pain; Peripheral Nerves; Prostaglandins; Spinal Cord; Substance P | 1999 |
2 trial(s) available for glutamic acid and capsaicin
| Article | Year |
|---|---|
Interactions between glutamate and capsaicin in inducing muscle pain and sensitization in humans.
Topics: Adult; Capsaicin; Double-Blind Method; Drug Interactions; Facial Pain; Female; Glutamic Acid; Humans; Injections, Intramuscular; Male; Masseter Muscle; Neurotoxins; Pain Measurement; Pain Threshold; Pressure | 2008 |
Orofacial antinociceptive activity of (S)-(-)-perillyl alcohol in mice: a randomized, controlled and triple-blind study.
Topics: Animals; Capsaicin; Facial Pain; Formaldehyde; Glutamic Acid; Male; Mice; Monoterpenes; Morphine; Pain Measurement | 2017 |
164 other study(ies) available for glutamic acid and capsaicin
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Cervical spinal cord neurons receiving sensory input from the cranial vasculature.
Topics: Action Potentials; Animals; Bradykinin; Capsaicin; Cats; Cerebral Arteries; Cervical Vertebrae; Cranial Sinuses; Decerebrate State; Electric Stimulation; Evoked Potentials; Female; Glutamates; Glutamic Acid; Homovanillic Acid; Male; Neurons; Reaction Time; Sensory Thresholds; Spinal Cord | 1991 |
Excitatory amino acids are released from rat primary afferent neurons in vitro.
Topics: Afferent Pathways; Animals; Animals, Newborn; Aspartic Acid; Capsaicin; Ganglia, Spinal; Glutamates; Glutamic Acid; Kinetics; Neurons; Neurotransmitter Agents; Organ Culture Techniques; Potassium; Rats | 1991 |
Outflow of endogenous aspartate and glutamate from the rat spinal dorsal horn in vitro by activation of low- and high-threshold primary afferent fibers. Modulation by mu-opioids.
Topics: Afferent Pathways; Animals; Aspartic Acid; Capsaicin; Diterpenes; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Ganglia, Spinal; Glutamates; Glutamic Acid; Glutamine; In Vitro Techniques; Kinetics; Naloxone; Nerve Fibers; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Spinal Cord; Time Factors | 1991 |
Depolarization-evoked release of glutamate, aspartate and gamma-aminobutyric acid from rat dorsal spinal cord slices does not originate from capsaicin-sensitive neurons.
Topics: Animals; Aspartic Acid; Capsaicin; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Immunohistochemistry; Neuromuscular Depolarizing Agents; Neurons; Potassium; Rats; Rats, Inbred Strains; Spinal Cord; Tetrodotoxin; Veratridine | 1991 |
The effects of substance P and calcitonin gene-related peptide on the efflux of endogenous glutamate and aspartate from the rat spinal dorsal horn in vitro.
Topics: Animals; Aspartic Acid; Calcitonin Gene-Related Peptide; Capsaicin; Glutamates; Glutamic Acid; In Vitro Techniques; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1990 |
Tachykinins and calcitonin gene-related peptide enhance release of endogenous glutamate and aspartate from the rat spinal dorsal horn slice.
Topics: Amino Acids; Animals; Aspartic Acid; Calcitonin Gene-Related Peptide; Capsaicin; Electric Stimulation; Female; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Neurokinin A; Rats; Rats, Inbred Strains; Recombinant Proteins; Spinal Cord; Spinal Nerve Roots; Substance P | 1990 |
Is substance P a primary afferent neurotransmitter for nociceptive input? I. Analysis of pain-related behaviors resulting from intrathecal administration of substance P and 6 excitatory compounds.
Topics: Afferent Pathways; Animals; Capsaicin; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; Injections, Spinal; Kainic Acid; Male; Morphine; Nociceptors; Pain; Picrotoxin; Rats; Rats, Inbred Strains; Spinal Cord; Strychnine; Substance P | 1988 |
Effect of a tachykinin antagonist on a nociceptive reflex in the isolated spinal cord-tail preparation of the newborn rat.
Topics: Analgesics; Animals; Animals, Newborn; Calcium; Capsaicin; Dose-Response Relationship, Drug; Glutamates; Glutamic Acid; In Vitro Techniques; Neuropeptides; Neurotransmitter Agents; Nociceptors; Rats; Reflex; Spinal Cord; Substance P; Tail; Thyrotropin-Releasing Hormone | 1988 |
Capsaicin does not change tissue levels of glutamic acid, its uptake, or release in the rat spinal cord.
Topics: Animals; Capsaicin; Fatty Acids, Unsaturated; Glutamates; Glutamic Acid; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Synaptosomes | 1982 |
The development of responsiveness to substance P and glutamate in the spinal motoneurons of rat fetuses.
Topics: Animals; Capsaicin; Cell Differentiation; Evoked Potentials; Female; Gestational Age; Glutamates; Glutamic Acid; Motor Neurons; Pregnancy; Rats; Rats, Inbred Strains; Spinal Cord; Substance P; Synaptic Transmission | 1984 |
Involvement of substance P and excitatory amino acids in aversive behavior elicited by intrathecal capsaicin.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Animals; Avoidance Learning; Biphenyl Compounds; Capsaicin; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Hypnotics and Sedatives; Injections, Spinal; Male; Nociceptors; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reinforcement, Psychology; Substance P; Synaptic Transmission | 1994 |
Evidence that glutamate is released from capsaicin-sensitive primary afferent fibers in rats: study with on-line continuous monitoring of glutamate.
Topics: Animals; Calcium; Capsaicin; Enzymes, Immobilized; Glutamate Dehydrogenase; Glutamic Acid; In Vitro Techniques; Male; Nerve Endings; Nerve Fibers; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P | 1994 |
Opioidergic inhibition of capsaicin-evoked release of glutamate from rat spinal dorsal horn slices.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzeneacetamides; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glutamate Dehydrogenase; Glutamic Acid; In Vitro Techniques; Male; Morphine; Nerve Endings; Neurons, Afferent; Opioid Peptides; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord | 1995 |
Capsaicin inhibits whereas rhizotomy potentiates substance P-induced release of excitatory amino acids in the rat spinal cord in vivo.
Topics: Animals; Aspartic Acid; Capsaicin; Glutamates; Glutamic Acid; Male; Rats; Rats, Sprague-Dawley; Reference Values; Spinal Cord; Spinal Nerves; Substance P | 1993 |
Alpha 2-adrenoceptor-mediated inhibition of capsaicin-evoked release of glutamate from rat spinal dorsal horn slices.
Topics: Adrenergic alpha-Agonists; Animals; Capsaicin; Electronic Data Processing; Glutamic Acid; In Vitro Techniques; Male; Monitoring, Physiologic; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Spinal Cord | 1995 |
L-glutamate activates peripheral nociceptors.
Topics: Acetylcholine; Animals; Animals, Newborn; Bradykinin; Capsaicin; Glutamates; Glutamic Acid; Motor Neurons; Neurons, Afferent; Nociceptors; Potassium; Rats; Serotonin; Spinal Cord; Tail | 1993 |
Detection of capsaicin-evoked release of glutamate from spinal dorsal horn slices of rat with on-line monitoring system.
Topics: Animals; Biosensing Techniques; Capsaicin; Enzymes, Immobilized; Fluorometry; Glutamate Dehydrogenase; Glutamates; Glutamic Acid; Male; Monitoring, Physiologic; Nerve Endings; Neurons, Afferent; Online Systems; Perfusion; Potassium; Rats; Rats, Sprague-Dawley; Spinal Cord; Tetrodotoxin | 1993 |
Evidence for release of glutamic acid, aspartic acid and substance P but not gamma-aminobutyric acid from primary afferent fibres in rat spinal cord.
Topics: Afferent Pathways; Animals; Aspartic Acid; Autoradiography; Capsaicin; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Rats; Rats, Wistar; Receptors, GABA-B; Spinal Cord; Substance P | 1996 |
Involvement of nitric oxide in spinally mediated capsaicin- and glutamate-induced behavioural responses in the mouse.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Capsaicin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Injections, Spinal; Kainic Acid; Male; Mice; Mice, Inbred Strains; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Receptors, Tachykinin; Spinal Cord | 1996 |
Visualization of glutamate release from rat spinal cord with a confocal laser scanning microscope.
Topics: Animals; Capsaicin; Glutamate Dehydrogenase; Glutamic Acid; In Vitro Techniques; Male; Microscopy, Confocal; NAD; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Spinal Cord; Tetrodotoxin | 1996 |
Temperature dependency of basal and evoked release of amino acids and calcitonin gene-related peptide from rat dorsal spinal cord.
Topics: Animals; Aspartic Acid; Body Temperature; Calcitonin Gene-Related Peptide; Calcium; Capsaicin; Chromatography, High Pressure Liquid; Cross Reactions; Fever; Glutamic Acid; Glycine; Hypothermia; Male; Organ Culture Techniques; Potassium; Rats; Rats, Sprague-Dawley; Serine; Spinal Cord; Synaptic Transmission | 1997 |
Afferent C-fibres release substance P and glutamate.
Topics: Animals; Capsaicin; Glutamic Acid; Male; Nerve Fibers; Neurons, Afferent; Potassium Chloride; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Time Factors | 1997 |
Effect of repeated cold stress on capsaicin-evoked release of glutamate from rat spinal dorsal horn slices.
Topics: Animals; Capsaicin; Cold Temperature; Glutamic Acid; Male; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Spinal Cord; Stress, Physiological | 1997 |
Spinal and supraspinal antinociceptive action of dipyrone in formalin, capsaicin and glutamate tests. Study of the mechanism of action.
Topics: Analgesics, Non-Narcotic; Animals; Capsaicin; Dipyrone; Enzyme Inhibitors; Formaldehyde; Glutamic Acid; Hyperalgesia; Male; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pain; Pain Measurement; Postural Balance; Psychomotor Performance; Rats; Rats, Wistar; Reaction Time; Spinal Cord | 1998 |
Increased spinal release of excitatory amino acids following intradermal injection of capsaicin is reduced by a protein kinase G inhibitor.
Topics: Alkaloids; Animals; Aspartic Acid; Capsaicin; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Glutamic Acid; Indoles; Injections, Intradermal; Isoquinolines; Male; Rats; Rats, Sprague-Dawley; Spinal Cord; Sulfonamides | 1998 |
Existence of capsaicin-sensitive glutamatergic terminals in rat hypothalamus.
Topics: Animals; Brain Chemistry; Capsaicin; Glutamic Acid; Hypothalamus; Male; Nerve Endings; Polymerase Chain Reaction; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, Drug; RNA, Messenger | 1998 |
Region-specific increase in glutamate release from dorsal horn of rats with adjuvant inflammation.
Topics: Animals; Capsaicin; Freund's Adjuvant; Glutamic Acid; Hyperalgesia; Male; Mycobacterium; Myelitis; Nociceptors; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Spinal Cord | 1998 |
Antinociception produced by systemic, spinal and supraspinal administration of amiloride in mice.
Topics: Acetic Acid; Amiloride; Animals; Animals, Newborn; Behavior, Animal; Capsaicin; Disease Models, Animal; Diuretics; Dose-Response Relationship, Drug; Drug Administration Routes; Formaldehyde; Glutamic Acid; Hot Temperature; Hyperalgesia; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Male; Mice; Muscle Contraction; Pain; Pain Measurement; Postural Balance | 1999 |
Assessment of mechanisms involved in antinociception caused by sesquiterpene polygodial.
Topics: Adrenalectomy; Analgesics; Animals; Capsaicin; Drug Interactions; Formaldehyde; Glutamic Acid; Hyperalgesia; Male; Mice; Pain Measurement; Sesquiterpenes | 2000 |
Peripheral glutamate release in the hindpaw following low and high intensity sciatic stimulation.
Topics: Amino Acids; Animals; Capsaicin; Electric Stimulation; Extracellular Space; Glutamic Acid; Hindlimb; Male; Microdialysis; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Sciatic Nerve | 2000 |
Involvement of glutamate in transmission of afferent constrictive inputs from the airways to the nucleus tractus solitarius in ferrets.
Topics: Aerosols; Animals; Blood Pressure; Bronchoconstriction; Capsaicin; Ferrets; Glutamic Acid; Heart Rate; Histamine; Lung; Male; Microdialysis; Neurons, Afferent; Oxygen; Parasympathetic Nervous System; Proto-Oncogene Proteins c-fos; Receptors, AMPA; Reflex; Respiration; Solitary Nucleus; Synaptic Transmission | 2000 |
Evidence that DHPG-induced nociception depends on glutamate release from primary afferent C-fibres.
Topics: 4-Aminopyridine; Animals; Behavior, Animal; Capsaicin; Excitatory Amino Acid Agonists; Glutamic Acid; Injections, Spinal; Lamotrigine; Male; Methoxyhydroxyphenylglycol; Nerve Fibers; Neurons, Afferent; Nociceptors; Proline; Propionates; Rats; Rats, Long-Evans; Riluzole; Triazines | 2000 |
Characterization of the glutamatergic system for induction and maintenance of allodynia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Transport System X-AG; Animals; Animals, Newborn; Aspartic Acid; ATP-Binding Cassette Transporters; Capsaicin; Dinoprost; Dinoprostone; Excitatory Amino Acid Agonists; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Pain; Pain Measurement; Physical Stimulation; Posterior Horn Cells; Receptors, Glutamate; Synapses; Synaptic Transmission; Touch | 2001 |
Brain-derived neurotrophic factor is released in the dorsal horn by distinctive patterns of afferent fiber stimulation.
Topics: Animals; Brain-Derived Neurotrophic Factor; Capsaicin; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme-Linked Immunosorbent Assay; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Male; Nerve Growth Factor; Neurons, Afferent; Posterior Horn Cells; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Spinal Nerve Roots; Stimulation, Chemical; Substance P | 2001 |
Cannabinoid-induced presynaptic inhibition of glutamatergic EPSCs in substantia gelatinosa neurons of the rat spinal cord.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics; Animals; Arachidonic Acids; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Capsaicin; Endocannabinoids; Excitatory Amino Acid Agonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Morpholines; Naphthalenes; Nerve Fibers; Neural Inhibition; Neurons; Patch-Clamp Techniques; Polyunsaturated Alkamides; Presynaptic Terminals; Rats; Rats, Wistar; Substantia Gelatinosa | 2001 |
alpha2A-adrenoceptor stimulation reduces capsaicin-induced glutamate release from spinal cord synaptosomes.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Capsaicin; Drug Interactions; Glutamic Acid; In Vitro Techniques; Male; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Spinal Cord; Synaptosomes | 2001 |
Glutamate release from adult primary sensory neurons in culture is modulated by growth factors.
Topics: Animals; Bradykinin; Brain-Derived Neurotrophic Factor; Calcium; Capsaicin; Cells, Cultured; Dose-Response Relationship, Drug; Fibroblast Growth Factor 2; Ganglia, Spinal; Glutamic Acid; Growth Substances; Immunohistochemistry; Male; Microscopy, Fluorescence; Nerve Growth Factor; Neuroglia; Neuronal Plasticity; Neurons, Afferent; Neuroprotective Agents; Potassium; Rats; Rats, Sprague-Dawley; Sciatic Nerve | 2001 |
Involvement of capsaicin-sensitive fibers in spinal NMDA-induced glutamate release.
Topics: Animals; Animals, Newborn; Capsaicin; Excitatory Amino Acid Agonists; Glutamic Acid; Injections, Spinal; Lumbar Vertebrae; Male; N-Methylaspartate; Nerve Fibers; Neurons, Afferent; Nitric Oxide; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord | 2001 |
Involvement of spinal N-methyl-D-aspartate receptors in capsaicin-induced in vivo release of substance P in the rat dorsal horn.
Topics: 2-Amino-5-phosphonovalerate; Animals; Capsaicin; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Microdialysis; Nerve Fibers; Nociceptors; Pain; Posterior Horn Cells; Quinoxalines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Substance P; Synapses; Synaptic Transmission | 2001 |
Intraplantar injection of glutamate evokes peripheral adenosine release in the rat hind paw: involvement of peripheral ionotropic glutamate receptors and capsaicin-sensitive sensory afferents.
Topics: Adenosine; Animals; Capsaicin; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Feedback, Physiological; Formaldehyde; Glutamic Acid; Hindlimb; Injections, Subcutaneous; Male; Microdialysis; Neurons, Afferent; Oxidopamine; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Skin | 2002 |
Anandamide inhibits excitatory transmission to rat substantia gelatinosa neurones in a manner different from that of capsaicin.
Topics: Animals; Arachidonic Acids; Calcium Channel Blockers; Capsaicin; Electric Stimulation; Endocannabinoids; Excitatory Postsynaptic Potentials; Glutamic Acid; Nerve Fibers; Nerve Fibers, Myelinated; Neural Conduction; Nociceptors; Pain; Polyunsaturated Alkamides; Rats; Substantia Gelatinosa; Synaptic Transmission | 2002 |
Capsaicin activation of glutamatergic synaptic transmission in the rat locus coeruleus in vitro.
Topics: Animals; Calcium; Capsaicin; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; In Vitro Techniques; Locus Coeruleus; Male; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Receptors, Drug; Synaptic Transmission | 2002 |
The role of neuropeptides and capsaicin-sensitive fibres in glutamate-induced nociception and paw oedema in mice.
Topics: Animals; Benzamides; Bradykinin Receptor Antagonists; Calcitonin Gene-Related Peptide; Capsaicin; Dipeptides; Edema; Foot; Glutamic Acid; Indoles; Male; Mice; Nerve Fibers; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain; Piperidines; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Receptors, Neurokinin-2 | 2003 |
Development of nociceptive synaptic inputs to the neonatal rat dorsal horn: glutamate release by capsaicin and menthol.
Topics: Action Potentials; Afferent Pathways; Animals; Animals, Newborn; Antipruritics; Calcium; Capsaicin; Excitatory Postsynaptic Potentials; Glutamic Acid; Menthol; Nociceptors; Patch-Clamp Techniques; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Drug; Rhizotomy; Synapses | 2003 |
Presynaptic facilitation of glutamatergic synapses to dopaminergic neurons of the rat substantia nigra by endogenous stimulation of vanilloid receptors.
Topics: Animals; Arachidonic Acids; Calcium; Calcium Channel Blockers; Capsaicin; Diterpenes; Dopamine; Dose-Response Relationship, Drug; Endocannabinoids; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamic Acid; In Vitro Techniques; Mesencephalon; Neurons; Patch-Clamp Techniques; Polyunsaturated Alkamides; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, Drug; RNA, Messenger; Substantia Nigra; Synapses; Synaptic Transmission; Tetrodotoxin | 2003 |
Contribution of spinal glutamatergic mechanisms in heterosegmental antinociception induced by noxious stimulation.
Topics: Animals; Benzoates; Capsaicin; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Isoquinolines; Male; Nociceptors; Pyridines; Quinoxalines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Spinal Cord; Stimulation, Chemical; Substance P | 2003 |
Cannabinoids inhibit the release of [3H]glutamate from rodent hippocampal synaptosomes via a novel CB1 receptor-independent action.
Topics: Analgesics; Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Capsaicin; Chromatography, High Pressure Liquid; Cyclohexanols; Dose-Response Relationship, Drug; Drug Interactions; Glutamic Acid; Hippocampus; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Radioactivity; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Synaptosomes; Tritium | 2003 |
Depletion of substance P and glutamate by capsaicin blocks respiratory rhythm in neonatal rat in vitro.
Topics: Amino Acid Transport System X-AG; Animals; Capsaicin; Excitatory Amino Acid Antagonists; Glutamic Acid; Immunohistochemistry; In Vitro Techniques; Medulla Oblongata; Nerve Fibers; Periodicity; Rats; Rats, Sprague-Dawley; Respiratory Mechanics; Respiratory Muscles; Substance P | 2004 |
Capsaicin increases GFAP and glutamine synthetase immunoreactivity in rat arcuate nucleus and median eminence.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Astrocytes; Capsaicin; Glial Fibrillary Acidic Protein; Glutamate-Ammonia Ligase; Glutamic Acid; Glutamine; Hypothalamo-Hypophyseal System; Immunohistochemistry; Male; Median Eminence; Neuronal Plasticity; Neurons; Nitric Oxide; Rats; Rats, Long-Evans; Stress, Physiological; Up-Regulation | 2004 |
VR1 receptor activation induces glutamate release and postsynaptic firing in the paraventricular nucleus.
Topics: Animals; Capsaicin; Diterpenes; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Male; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Receptors, Drug | 2004 |
Purinergic and vanilloid receptor activation releases glutamate from separate cranial afferent terminals in nucleus tractus solitarius.
Topics: Adenosine Triphosphate; Afferent Pathways; Animals; Capsaicin; Cell Separation; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Male; Neural Inhibition; Neurons; Nodose Ganglion; Patch-Clamp Techniques; Presynaptic Terminals; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Rats; Rats, Sprague-Dawley; Receptors, Drug; Receptors, Purinergic P2; Solitary Nucleus | 2004 |
Alpha(2A) adrenoceptors contribute to feedback inhibition of capsaicin-induced hyperalgesia.
Topics: Administration, Rectal; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Capsaicin; Colon; Feedback; Foot; Glutamic Acid; Hyperalgesia; Injections; Mice; Mice, Knockout; Pain Measurement; Receptors, Adrenergic, alpha-2; Spinal Cord; Synaptosomes | 2004 |
AM404 enhances the spontaneous release of L-glutamate in a manner sensitive to capsazepine in adult rat substantia gelatinosa neurones.
Topics: Anesthetics, Local; Animals; Arachidonic Acids; Biological Transport; Capsaicin; Drug Interactions; Endocannabinoids; Glutamic Acid; Male; Neurons; Polyunsaturated Alkamides; Rats; Receptors, Drug; Substantia Gelatinosa; Tetrodotoxin | 2004 |
Vanilloid receptor VR1-positive primary afferents are glutamatergic and contact spinal neurons that co-express neurokinin receptor NK1 and glutamate receptors.
Topics: Afferent Pathways; Animals; Capsaicin; Fluorescent Antibody Technique; Glutamic Acid; Immunohistochemistry; Male; Membrane Transport Proteins; Microscopy, Electron, Transmission; Nociceptors; Pain; Posterior Horn Cells; Presynaptic Terminals; Protein Subunits; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Drug; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Spinal Nerve Roots; Substance P; Synaptic Transmission; Vesicular Glutamate Transport Protein 2 | 2004 |
Nitric oxide-induced increase of excitatory amino acid levels in the trigeminal nucleus caudalis of the rat with tactile hypersensitivity evoked by the loose-ligation of the inferior alveolar nerves.
Topics: Animals; Aspartic Acid; Benzoates; Capsaicin; Dental Pulp; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors; Excitatory Amino Acids; Glutamic Acid; Hyperalgesia; Imidazoles; Injections, Subcutaneous; Ligation; Lip; Male; Mandibular Nerve; Microdialysis; Nitric Oxide; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; S-Nitroso-N-Acetylpenicillamine; Trigeminal Nuclei | 2004 |
Functional similarities and differences of AMPA and kainate receptors expressed by cultured rat sensory neurons.
Topics: Action Potentials; Animals; Capsaicin; Cells, Cultured; Embryo, Mammalian; Excitatory Postsynaptic Potentials; Ganglia, Spinal; Glutamic Acid; Neurons, Afferent; Patch-Clamp Techniques; Rats; Receptors, AMPA; Receptors, Kainic Acid | 2004 |
Nociceptive transmitter release in the dorsal spinal cord by capsaicin-sensitive fibers after noxious gastric stimulation.
Topics: Amino Acid Transport System X-AG; Animals; Autonomic Denervation; Calcitonin Gene-Related Peptide; Capsaicin; Female; Ganglia, Spinal; Gastric Mucosa; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Immunohistochemistry; Ion Channels; Neurons, Afferent; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Symporters; Thoracic Vertebrae; TRPV Cation Channels; Visceral Afferents | 2005 |
Protein phosphatase modulates the phosphorylation of spinal cord NMDA receptors in rats following intradermal injection of capsaicin.
Topics: Administration, Cutaneous; Animals; Capsaicin; Disease Models, Animal; Enzyme Inhibitors; Glutamic Acid; Male; Microdialysis; Neurons, Afferent; Nociceptors; Pain; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Synaptic Transmission | 2005 |
Arvanil, a hybrid endocannabinoid and vanilloid compound, behaves as an antihyperkinetic agent in a rat model of Huntington's disease.
Topics: Animals; Brain Chemistry; Capsaicin; Convulsants; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Huntington Disease; Hyperkinesis; Male; Motor Activity; Nitro Compounds; Propionates; Rats; Rats, Sprague-Dawley | 2005 |
Adenosine reduces glutamate release in rat spinal synaptosomes.
Topics: Adenosine; Adenosine A1 Receptor Antagonists; Animals; Capsaicin; Glutamic Acid; In Vitro Techniques; Ligation; Male; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Nerves; Synaptosomes; TRPV Cation Channels | 2005 |
Antinociceptive properties of the ethanolic extract and of the triterpene 3beta,6beta,16beta-trihidroxilup-20(29)-ene obtained from the flowers of Combretum leprosum in mice.
Topics: Acetic Acid; Analgesics; Animals; Arginine; Capsaicin; Combretum; Endorphins; Flowers; Formaldehyde; Glutamic Acid; Male; Mice; Motor Activity; Nitric Oxide; Pain; Pain Measurement; Plant Extracts; Psychomotor Performance; Reaction Time; Serotonin; Triterpenes | 2006 |
Effect of morphine on the release of excitatory amino acids in the rat hind instep: Pain is modulated by the interaction between the peripheral opioid and glutamate systems.
Topics: Analgesics, Opioid; Animals; Aspartic Acid; Capsaicin; Disease Models, Animal; Drug Interactions; Electric Stimulation; Glutamic Acid; Hot Temperature; Male; Morphine; Narcotic Antagonists; Nerve Fibers, Unmyelinated; Neural Conduction; Nociceptors; Opioid Peptides; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Opioid; Sensory Receptor Cells; Signal Transduction | 2006 |
Assessing mechanical sensitivity of masseter muscle in lightly anesthetized rats: a model for craniofacial muscle hyperalgesia.
Topics: Analgesics, Non-Narcotic; Anesthesia; Animals; Behavior; Bradykinin; Capsaicin; Facial Pain; Glutamic Acid; Humans; Hyperalgesia; Male; Masseter Muscle; Models, Biological; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley | 2006 |
TRPV1 receptor mediates glutamatergic synaptic input to dorsolateral periaqueductal gray (dl-PAG) neurons.
Topics: Action Potentials; Afferent Pathways; Animals; Autonomic Pathways; Capsaicin; Cardiovascular Physiological Phenomena; Diterpenes; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Inhibitory Postsynaptic Potentials; Male; Neurons; Organ Culture Techniques; Pain; Patch-Clamp Techniques; Periaqueductal Gray; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Synaptic Transmission; TRPV Cation Channels | 2007 |
Increased nociceptive input rapidly modulates spinal GABAergic transmission through endogenously released glutamate.
Topics: Afferent Pathways; Animals; Capsaicin; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Inhibitory Postsynaptic Potentials; Interneurons; Male; Neural Inhibition; Nociceptors; Organ Culture Techniques; Pain; Pertussis Toxin; Posterior Horn Cells; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, GABA-A; Receptors, Metabotropic Glutamate; Spinal Nerve Roots; Synaptic Transmission | 2007 |
Vanilloid (subtype 1) receptor-modulatory drugs inhibit [3H]batrachotoxinin-A 20-alpha-benzoate binding to Na+ channels.
Topics: Animals; Aspartic Acid; Batrachotoxins; Brain; Capsaicin; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Inbred Strains; Potassium Chloride; Sodium Channels; Synaptosomes; Tritium; TRPV Cation Channels; Veratridine | 2007 |
Analysis of the mechanism of antinociceptive action of niga-ichigoside F1 obtained from Rubus imperialis (Rosaceae).
Topics: Analgesics; Animals; Apomorphine; Atropine; Capsaicin; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Glutamic Acid; Haloperidol; Injections, Intraperitoneal; Male; Mice; Molecular Structure; Morphine; Naloxone; Nitroarginine; Pain; Pain Measurement; Plant Extracts; Rosaceae; Saponins; Yohimbine | 2006 |
Inward currents induced by ischemia in rat spinal cord dorsal horn neurons.
Topics: Age Factors; Animals; Animals, Newborn; Capsaicin; Electric Stimulation; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Ischemia; Organ Culture Techniques; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Spinal Cord | 2007 |
Antinociceptive action of myricitrin: involvement of the K+ and Ca2+ channels.
Topics: Acetic Acid; Analgesics; Animals; Calcium Channels; Calcium Radioisotopes; Calcium Signaling; Capsaicin; Female; Flavonoids; Glutamic Acid; GTP-Binding Protein alpha Subunits, Gi-Go; Injections, Intraventricular; Injections, Spinal; Interleukin-1beta; Ion Channel Gating; Male; Mice; Pain; Pain Measurement; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Substance P; Tumor Necrosis Factor-alpha | 2007 |
Evidence for the involvement of glutamatergic and GABAergic systems and protein kinase A pathway in the antinociceptive effect caused by p-methoxy-diphenyl diselenide in mice.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acetic Acid; Analgesics; Animals; Benzene Derivatives; Capsaicin; Cyclic AMP-Dependent Protein Kinases; Edema; Enzyme Activators; Excitatory Amino Acids; Female; Formaldehyde; gamma-Aminobutyric Acid; Glutamic Acid; Hot Temperature; Immersion; Injections, Spinal; Mice; Motor Activity; Organoselenium Compounds; Pain; Reaction Time; Signal Transduction | 2008 |
Tonic endovanilloid facilitation of glutamate release in brainstem descending antinociceptive pathways.
Topics: Action Potentials; Animals; Brain Stem; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glutamic Acid; Hot Temperature; Male; Microdialysis; Microinjections; Neural Pathways; Neurons, Efferent; Pain; Pain Measurement; Pain Threshold; Periaqueductal Gray; Rats; Rats, Wistar; Reaction Time; Sensory System Agents; TRPV Cation Channels | 2007 |
Further antinociceptive properties of extracts and phenolic compounds from Plinia glomerata (Myrtaceae) leaves.
Topics: Acetic Acid; Acetone; Analgesics; Analgesics, Opioid; Animals; Capsaicin; Ellagic Acid; Formaldehyde; Glutamic Acid; Hot Temperature; Injections, Intraperitoneal; Male; Methanol; Mice; Morphine; Myrtaceae; Pain Measurement; Phenols; Plant Extracts; Plant Leaves; Solvents | 2008 |
Paraventricular nucleus is involved in the central pathway of cardiac sympathetic afferent reflex in rats.
Topics: Afferent Pathways; Anesthetics, Local; Animals; Blood Pressure; Bradykinin; Capsaicin; Central Nervous System; Excitatory Amino Acid Agonists; Glutamic Acid; Heart; Kainic Acid; Lidocaine; Male; Microinjections; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Reflex; Sympathetic Nervous System | 2008 |
Mechanisms of prolonged presynaptic Ca2+ signaling and glutamate release induced by TRPV1 activation in rat sensory neurons.
Topics: Action Potentials; Afferent Pathways; Animals; Animals, Newborn; Arachidonic Acids; Calcium; Calcium Signaling; Capsaicin; Cells, Cultured; Coculture Techniques; Dopamine; Ganglia, Spinal; Glutamic Acid; Mitochondria; Neurons, Afferent; Nociceptors; Pain; Patch-Clamp Techniques; Posterior Horn Cells; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Spinal Nerve Roots; Synaptic Transmission; TRPV Cation Channels | 2008 |
Quercetin: further investigation of its antinociceptive properties and mechanisms of action.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Capsaicin; Cholinergic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Formaldehyde; GABA Agents; Glutamic Acid; Hot Temperature; Male; Mice; Motor Activity; Nitric Oxide Synthase; Pain; Pain Measurement; Pain Threshold; Quercetin; Reaction Time; Serotonin Antagonists; Signal Transduction | 2008 |
Genetic deletion of synapsin II reduces neuropathic pain due to reduced glutamate but increased GABA in the spinal cord dorsal horn.
Topics: Activating Transcription Factor 3; Adenosine Triphosphate; Afferent Pathways; Animals; Calcium Signaling; Capsaicin; Female; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Posterior Horn Cells; Sciatic Nerve; Sciatica; Spinal Cord; Synapsins | 2008 |
Antinociceptive effects of intracerebroventricular administration of guanine-based purines in mice: evidences for the mechanism of action.
Topics: Analgesics; Animals; Brain Chemistry; Capsaicin; Chromatography, High Pressure Liquid; Glutamic Acid; Guanosine; Guanosine Monophosphate; Hot Temperature; Injections, Intraventricular; Male; Mice; Motor Activity; Naloxone; Narcotic Antagonists; Pain Measurement; Postural Balance; Psychomotor Performance; Reaction Time | 2008 |
Comparison of baroreceptive to other afferent synaptic transmission to the medial solitary tract nucleus.
Topics: Afferent Pathways; Animals; Aorta; Axons; Capsaicin; Cranial Nerves; Electric Stimulation; Evoked Potentials; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Male; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Pressoreceptors; Rats; Rats, Sprague-Dawley; Reaction Time; Solitary Nucleus; Synaptic Transmission; Time Factors | 2008 |
TRPV1 channels facilitate glutamate transmission in the striatum.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Capsaicin; Corpus Striatum; Endocannabinoids; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Patch-Clamp Techniques; Polyunsaturated Alkamides; Protein Kinase C; Sensory System Agents; Synaptic Transmission; Tetradecanoylphorbol Acetate; TRPV Cation Channels | 2009 |
The glutamatergic nature of TRPV1-expressing neurons in the spinal dorsal horn.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Capsaicin; Diterpenes; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Ganglia, Spinal; Gene Expression; Glutamic Acid; Glycoproteins; In Vitro Techniques; Lectins; Male; Muscarinic Agonists; Oxotremorine; Patch-Clamp Techniques; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Rhizotomy; Spinal Cord; TRPV Cation Channels; Versicans; Vesicular Glutamate Transport Protein 2 | 2009 |
Glutamate and capsaicin effects on trigeminal nociception I: Activation and peripheral sensitization of deep craniofacial nociceptive afferents.
Topics: Afferent Pathways; Animals; Capsaicin; Face; Facial Pain; Glutamic Acid; Male; Mechanoreceptors; Nociceptors; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Sensory Receptor Cells; Sensory System Agents; Trigeminal Nerve; TRPV Cation Channels | 2009 |
Glutamate and capsaicin effects on trigeminal nociception II: activation and central sensitization in brainstem neurons with deep craniofacial afferent input.
Topics: Action Potentials; Analysis of Variance; Animals; Capsaicin; Glutamic Acid; Male; Microelectrodes; Neurons, Afferent; Nociceptors; Physical Stimulation; Rats; Rats, Sprague-Dawley; Sensory System Agents; Temporomandibular Joint; Trigeminal Caudal Nucleus | 2009 |
N-acyldopamines control striatal input terminals via novel ligand-gated cation channels.
Topics: Animals; Arachidonic Acids; Boron Compounds; Capsaicin; Cations; Corpus Striatum; Dopamine; Endocannabinoids; Glutamic Acid; Ion Channels; Ligands; Male; Mice; Mice, Mutant Strains; Polyunsaturated Alkamides; Presynaptic Terminals; Rats; Rats, Wistar; Synaptosomes; TRPV Cation Channels | 2009 |
Anti-nociceptive properties of the xanthine oxidase inhibitor allopurinol in mice: role of A1 adenosine receptors.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Adenosine A2 Receptor Antagonists; Allopurinol; Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Glutamic Acid; Hot Temperature; Injections, Intraperitoneal; Male; Mice; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pyrimidines; Triazoles; Uric Acid; Xanthine Oxidase; Xanthines | 2009 |
Glutamate and capsaicin-induced pain, hyperalgesia and modulatory interactions in human tendon tissue.
Topics: Adult; Analysis of Variance; Capsaicin; Drug Interactions; Glutamic Acid; Humans; Hyperalgesia; Male; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Tendons; Young Adult | 2009 |
Algesic agents exciting muscle nociceptors.
Topics: Adenosine Triphosphate; Animals; Bradykinin; Capsaicin; Glutamic Acid; Hydrogen-Ion Concentration; Interleukins; Muscles; Nerve Growth Factor; Nociceptors; Pain; Potassium Chloride; Prostaglandins; Protons; Rats; Serotonin; Sodium Chloride | 2009 |
Capsaicin-induced glutamate release is implicated in nociceptive processing through activation of ionotropic glutamate receptors and group I metabotropic glutamate receptor in primary afferent fibers.
Topics: Animals; Capsaicin; Glutamic Acid; Hyperalgesia; Male; Nerve Fibers; Nociceptors; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Sensory System Agents; Time Factors; TRPV Cation Channels | 2009 |
Extreme tolerance to ammonia fumes in African naked mole-rats: animals that naturally lack neuropeptides from trigeminal chemosensory nerve fibers.
Topics: Ammonia; Animals; Capsaicin; Central Nervous System; Discrimination Learning; Exploratory Behavior; Glutamic Acid; Irritants; Mice; Mice, Inbred C57BL; Mole Rats; Nerve Fibers, Unmyelinated; Nerve Tissue Proteins; Neuropeptides; Nicotine; Nociceptors; Odorants; Olivary Nucleus; Proto-Oncogene Proteins c-fos; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Single-Blind Method; Solitary Nucleus; Species Specificity; Trigeminal Nucleus, Spinal | 2009 |
Transient receptor potential vanilloid type 1 receptor regulates glutamatergic synaptic inputs to the spinothalamic tract neurons of the spinal cord deep dorsal horn.
Topics: Animals; Calcium Channels; Capsaicin; Excitatory Postsynaptic Potentials; Female; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Male; Miniature Postsynaptic Potentials; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Sensory System Agents; Spinothalamic Tracts; Statistics, Nonparametric; Synaptic Transmission; TRPV Cation Channels | 2009 |
Functional interaction between TRPV1 and mu-opioid receptors in the descending antinociceptive pathway activates glutamate transmission and induces analgesia.
Topics: Action Potentials; Animals; Capsaicin; Diterpenes; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Glutamic Acid; Hyperalgesia; Male; Medulla Oblongata; Microinjections; Naloxone; Pain Measurement; Pain Threshold; Periaqueductal Gray; Rats; Rats, Wistar; Reaction Time; Receptors, Opioid, mu; TRPV Cation Channels | 2009 |
Depolarization-induced release of endocannabinoids by murine dorsal motor nucleus of the vagus nerve neurons differentially regulates inhibitory and excitatory neurotransmission.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Arachidonic Acids; Benzoxazines; Brain Stem; Calcium Signaling; Cannabinoid Receptor Modulators; Capsaicin; Efferent Pathways; Endocannabinoids; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Inhibitory Postsynaptic Potentials; Kynurenic Acid; Male; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Neurons; Piperidines; Pyrazoles; Pyridazines; Receptor, Cannabinoid, CB1; Receptors, Presynaptic; Rimonabant; Tetrodotoxin; Vagus Nerve | 2009 |
Filicene obtained from Adiantum cuneatum interacts with the cholinergic, dopaminergic, glutamatergic, GABAergic, and tachykinergic systems to exert antinociceptive effect in mice.
Topics: Acetic Acid; Adiantum; Analgesics; Animals; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Male; Mice; Molecular Structure; Pain; Phytotherapy; Plants, Medicinal; Receptors, Cholinergic; Receptors, Dopamine; Receptors, GABA; Receptors, Neurotransmitter; Receptors, Tachykinin; Triterpenes | 2009 |
A transient receptor potential-like channel mediates synaptic transmission in rod bipolar cells.
Topics: Amino Acids; Anilides; Animals; Arachidonic Acids; Capsaicin; Cinnamates; Endocannabinoids; Excitatory Amino Acid Antagonists; Glutamic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Polyunsaturated Alkamides; Propionates; Receptors, Metabotropic Glutamate; Retinal Bipolar Cells; Ruthenium Red; Synaptic Transmission; Transient Receptor Potential Channels; TRPM Cation Channels; TRPV Cation Channels; Xanthenes | 2009 |
Transient receptor potential A1 increase glutamate release on brain stem neurons.
Topics: Animals; Ankyrins; Cadmium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Capsaicin; Cells, Cultured; Excitatory Postsynaptic Potentials; Glutamic Acid; Isothiocyanates; Male; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Ruthenium Red; Solitary Nucleus; Tetrodotoxin; TRPA1 Cation Channel; TRPC Cation Channels | 2009 |
Antinociceptive and anti-allodynic effects of 3-alkynyl selenophene on different models of nociception in mice.
Topics: Analgesics; Animals; Bradykinin; Capsaicin; Formaldehyde; Freund's Adjuvant; Glutamic Acid; Hot Temperature; Hyperalgesia; Immersion; Inflammation; Male; Mice; Motor Activity; Organoselenium Compounds; Pain Measurement; Reaction Time; Tetradecanoylphorbol Acetate | 2009 |
Antinociceptive activity of a new benzofuranone derived from a chalcone.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Benzofurans; Capsaicin; Chalcone; Dose-Response Relationship, Drug; Formaldehyde; Glutamic Acid; Linear Models; Male; Mice; Nociception; Pain; Pain Measurement | 2009 |
Electrophysiological and morphological properties of neurons in the substantia gelatinosa of the mouse trigeminal subnucleus caudalis.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Capsaicin; Electrophysiology; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Neurons; Nociceptors; Patch-Clamp Techniques; Receptors, Presynaptic; Receptors, Purinergic P2; Substantia Gelatinosa; Transient Receptor Potential Channels; Trigeminal Nucleus, Spinal | 2009 |
Effect of resiniferatoxin on glutamatergic spontaneous excitatory synaptic transmission in substantia gelatinosa neurons of the adult rat spinal cord.
Topics: Animals; Capsaicin; Diterpenes; Glutamic Acid; In Vitro Techniques; Isothiocyanates; Male; Patch-Clamp Techniques; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Substantia Gelatinosa; Synaptic Transmission; TRPV Cation Channels | 2009 |
Parathyroid hormone 2 receptor is a functional marker of nociceptive myelinated fibers responsible for neuropathic pain.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Ganglia, Spinal; Gene Expression Regulation; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Nerve Fibers, Myelinated; Neurons; Neuropeptides; Pain; Pain Measurement; Piperidines; Receptor, Parathyroid Hormone, Type 2; Reflex; Sciatica; Signal Transduction; Time Factors; TRPV Cation Channels | 2010 |
Neuroprotection induced by vitamin E against oxidative stress in hippocampal neurons: involvement of TRPV1 channels.
Topics: alpha-Tocopherol; Animals; Calcium; Capsaicin; Cell Death; Cells, Cultured; Diterpenes; Electric Conductivity; Ferrous Compounds; Glutamic Acid; Hippocampus; Neurons; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley; Synaptic Transmission; TRPV Cation Channels | 2010 |
Interactions of glutamate and capsaicin-evoked muscle pain on jaw motor functions of men.
Topics: Adult; Analysis of Variance; Capsaicin; Double-Blind Method; Electromyography; Facial Pain; Glutamic Acid; Humans; Jaw; Male; Movement; Muscle Contraction; Muscle, Skeletal; Pain Measurement | 2010 |
Diabetic thermal hyperalgesia: role of TRPV1 and CB1 receptors of periaqueductal gray.
Topics: Analgesia; Analgesics; Animals; Benzoxazines; Capsaicin; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Down-Regulation; gamma-Aminobutyric Acid; Glutamic Acid; Hyperalgesia; Male; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Nociceptors; Periaqueductal Gray; Rats; Receptor, Cannabinoid, CB1; RNA, Messenger; TRPV Cation Channels; Up-Regulation | 2010 |
Primary afferent activation of thermosensitive TRPV1 triggers asynchronous glutamate release at central neurons.
Topics: Afferent Pathways; Anilides; Animals; Capsaicin; Cinnamates; Electric Stimulation; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Male; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sensory System Agents; Solitary Nucleus; Thermosensing; TRPV Cation Channels | 2010 |
Antinociceptive effect of Zanthoxylum rhoifolium Lam. (Rutaceae) in models of acute pain in rodents.
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Dizocilpine Maleate; Ethanol; Female; Formaldehyde; Glutamic Acid; Locomotion; Male; Mice; Morphine; Pain; Pentacyclic Triterpenes; Phytotherapy; Plant Bark; Plant Extracts; Plant Stems; Zanthoxylum | 2010 |
Metabotropic glutamate receptors (mGluRs) regulate noxious stimulus-induced glutamate release in the spinal cord dorsal horn of rats with neuropathic and inflammatory pain.
Topics: Animals; Capsaicin; Glutamic Acid; Inflammation; Male; Pain; Pain Measurement; Peripheral Nervous System Diseases; Posterior Horn Cells; Rats; Rats, Long-Evans; Receptors, Metabotropic Glutamate | 2010 |
The endocannabinoid system in rat gliosomes and its role in the modulation of glutamate release.
Topics: Animals; Arachidonic Acids; Astrocytes; Cannabinoid Receptor Modulators; Cannabinoids; Capsaicin; Endocannabinoids; Glutamic Acid; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Synaptosomes; TRPV Cation Channels | 2011 |
Antinociceptive activity of a synthetic chalcone, flavokawin B on chemical and thermal models of nociception in mice.
Topics: Analgesics; Animals; Capsaicin; Chalcones; Flavonoids; Glutamic Acid; Male; Mice; Mice, Inbred ICR; Models, Chemical; Motor Activity; Pain; Pain Measurement; Plant Extracts; Reaction Time; Receptors, Opioid | 2010 |
Thermally active TRPV1 tonically drives central spontaneous glutamate release.
Topics: Action Potentials; Anilides; Animals; Cadmium Compounds; Calcium; Capsaicin; Cinnamates; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Male; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium Channel Blockers; Synapses; Tetrodotoxin; Thermosensing; TRPV Cation Channels | 2010 |
VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch.
Topics: Acute Disease; Animals; Capsaicin; Cell Count; Chronic Disease; Glutamic Acid; Immunohistochemistry; Mice; Mice, Knockout; Mice, Transgenic; Mutation; NAV1.8 Voltage-Gated Sodium Channel; Neural Pathways; Neurons; Nociceptors; Pain; Patch-Clamp Techniques; Pruritus; Receptors, Bombesin; Sodium Channels; Spinal Cord; Synaptic Transmission; Vesicular Glutamate Transport Protein 2 | 2010 |
The effect of spider toxin PhTx3-4, ω-conotoxins MVIIA and MVIIC on glutamate uptake and on capsaicin-induced glutamate release and [Ca2+]i in spinal cord synaptosomes.
Topics: Animals; Calcium; Capsaicin; Fluorescence; Glutamic Acid; Male; Neuropeptides; omega-Conotoxins; Rats; Rats, Wistar; Spider Venoms; Spinal Cord; Synaptosomes | 2011 |
Intracellular acidification is associated with changes in free cytosolic calcium and inhibition of action potentials in rat trigeminal ganglion.
Topics: Action Potentials; Animals; Calcium; Capsaicin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Glutamic Acid; Hydrogen-Ion Concentration; Membrane Transport Modulators; Neurons; Plasma Membrane Calcium-Transporting ATPases; Rats; Rats, Sprague-Dawley; Sensory System Agents; Sodium-Bicarbonate Symporters; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Trigeminal Ganglion; TRPV Cation Channels | 2011 |
Capsaicin in the periaqueductal gray induces analgesia via metabotropic glutamate receptor-mediated endocannabinoid retrograde disinhibition.
Topics: Analgesics; Animals; Arachidonic Acids; Capsaicin; Cell Membrane; Endocannabinoids; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamic Acid; Glycerides; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Lipoprotein Lipase; Neurons; Pain Measurement; Patch-Clamp Techniques; Periaqueductal Gray; Protein Kinase C; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Signal Transduction; Synaptic Transmission; TRPV Cation Channels | 2011 |
Vanilloid, purinergic, and CCK receptors activate glutamate release on single neurons of the nucleus tractus solitarius centralis.
Topics: Action Potentials; Animals; Capsaicin; Cells, Cultured; Cholecystokinin; Female; Glutamic Acid; Male; Neurons; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Receptors, Purinergic; Solitary Nucleus; TRPV Cation Channels | 2011 |
Group II/III metabotropic glutamate receptors exert endogenous activity-dependent modulation of TRPV1 receptors on peripheral nociceptors.
Topics: Amino Acids; Animals; Calcium; Capsaicin; Cells, Cultured; Cytosol; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Formaldehyde; Glutamic Acid; Hot Temperature; Male; Nociceptors; Pain; Pain Measurement; Peripheral Nervous System; Proline; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Skin; TRPV Cation Channels; Xanthenes | 2011 |
TRPV1 marks synaptic segregation of multiple convergent afferents at the rat medial solitary tract nucleus.
Topics: Afferent Pathways; Animals; Brain Stem; Capsaicin; Electric Stimulation; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Sensory System Agents; Solitary Nucleus; Synaptic Transmission; TRPV Cation Channels; Visceral Afferents | 2011 |
Evaluation of antinociceptive effects of Crassocephalum bauchiense Hutch (Asteraceae) leaf extract in rodents.
Topics: Acetic Acid; Administration, Oral; Alkaloids; Analgesics; Analgesics, Opioid; Animals; Asteraceae; Behavior, Animal; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Formaldehyde; Glutamic Acid; Hot Temperature; Male; Mice; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Pain; Pain Threshold; Phytotherapy; Plant Extracts; Plant Leaves; Plants, Medicinal; Solvents; Time Factors; Water | 2012 |
The involvement of the spinal release of glutamate and nitric oxide in peripheral noxious stimulation-induced pain-related behaviors--study in mouse spinal microdialysis.
Topics: Animals; Behavior, Animal; Capsaicin; Formaldehyde; Glutamic Acid; Male; Mice; Microdialysis; Nitric Oxide; Pain; Pain Measurement; Spinal Cord | 2012 |
G-protein-mediated inhibition of the Trp channel TRPM1 requires the Gβγ dimer.
Topics: Amino Acids; Animals; Capsaicin; Cells, Cultured; Excitatory Amino Acid Antagonists; Glutamic Acid; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; HEK293 Cells; Humans; Light; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein Binding; Protein Multimerization; Receptors, Metabotropic Glutamate; Retinal Bipolar Cells; TRPM Cation Channels; Xanthenes | 2012 |
Inhibitory control of nociceptive responses of trigeminal spinal nucleus cells by somatosensory corticofugal projection in rat.
Topics: Action Potentials; Afferent Pathways; Animals; Bicuculline; Biophysics; Capsaicin; Constriction; Disease Models, Animal; Electric Stimulation; Female; GABA-A Receptor Antagonists; Glutamic Acid; Glycine Agents; Hyperalgesia; Iontophoresis; Male; Neural Inhibition; Neuralgia; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Somatosensory Cortex; Strychnine; Time Factors; Trigeminal Nucleus, Spinal | 2012 |
Combined treatment with capsaicin and resveratrol enhances neuroprotection against glutamate-induced toxicity in mouse cerebral cortical neurons.
Topics: Animals; Antioxidants; Apoptosis; bcl-X Protein; Capsaicin; Cell Survival; Cells, Cultured; Cerebral Cortex; Cytoplasm; Drug Therapy, Combination; Female; Gene Expression Regulation, Enzymologic; Glutamic Acid; Glutathione Peroxidase; Interleukin-1beta; Male; Mice; Mice, Inbred ICR; Neurons; Neuroprotective Agents; Reactive Oxygen Species; Resveratrol; Sirtuin 1; Stilbenes; Superoxide Dismutase; TRPV Cation Channels; Tumor Necrosis Factor-alpha | 2012 |
Hyptis pectinata: redox protection and orofacial antinociception.
Topics: Analgesics; Animals; Biphenyl Compounds; Capsaicin; Facial Pain; Free Radical Scavengers; Glutamic Acid; Hyptis; Lipid Peroxidation; Male; Mice; Morphine; Pain Measurement; Picrates; Plant Extracts; Plant Leaves; Thiobarbituric Acid Reactive Substances | 2013 |
Evidence for the analgesic activity of resveratrol in acute models of nociception in mice.
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Male; Mice; Molecular Structure; Nociception; Pain Measurement; Proto-Oncogene Proteins c-fos; Resveratrol; Stereoisomerism; Stilbenes | 2013 |
Orofacial antinociceptive effect and antioxidant properties of the hydroethanol extract of Hyptis fruticosa salmz ex Benth.
Topics: Analgesics; Animals; Antioxidants; Behavior, Animal; Capsaicin; Ethanol; Facial Pain; Formaldehyde; Glutamic Acid; Hyptis; Male; Mice; Phenols; Phytotherapy; Plant Extracts; Plant Leaves; Solvents; Terpenes; Thiobarbituric Acid Reactive Substances | 2013 |
Antinociceptive effect of Lecythis pisonis Camb. (Lecythidaceae) in models of acute pain in mice.
Topics: Acetic Acid; Acute Pain; Analgesics; Animals; Arginine; Behavior, Animal; Capsaicin; Disease Models, Animal; Formaldehyde; Glutamic Acid; Glyburide; Lecythidaceae; Male; Mice; Naloxone; Narcotic Antagonists; Phytotherapy; Plant Extracts; Plant Leaves | 2013 |
Anti-hyperalgesic activity of corilagin, a tannin isolated from Phyllanthus niruri L. (Euphorbiaceae).
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Capsaicin; Formaldehyde; Glucosides; Glutamic Acid; Hot Temperature; Hydrolyzable Tannins; Hyperalgesia; Male; Mice; Motor Activity; Phyllanthus; Phytotherapy | 2013 |
Lateral reticular nucleus modulates the cardiosomatic reflex evoked by intrapericardial capsaicin in the rat.
Topics: Animals; Capsaicin; Electric Stimulation; Electromyography; Glutamic Acid; Heart; Male; Medulla Oblongata; Muscle Contraction; Muscle, Skeletal; Naloxone; Neural Pathways; Rats; Rats, Sprague-Dawley; Reflex; Sensory System Agents | 2013 |
Evaluation of mechanisms involved in the antinociception of the ethanol extract from the inner bark of Caesalpinia pyramidalis in mice.
Topics: Acetic Acid; Analgesics; Animals; Arginine; Behavior, Animal; Caesalpinia; Capsaicin; Ethanol; Female; Glutamic Acid; Male; Mice; Nitric Oxide; Pain; Phytotherapy; Plant Bark; Plant Extracts; Solvents | 2013 |
Presynaptic TRPV1 vanilloid receptor function is age- but not CB1 cannabinoid receptor-dependent in the rodent forebrain.
Topics: Animals; Capsaicin; Corpus Striatum; Dopamine; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; In Vitro Techniques; Male; Mice; Mice, Knockout; Presynaptic Terminals; Radionuclide Imaging; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Serotonin; TRPV Cation Channels | 2013 |
β-cyclodextrin complex containing Lippia grata leaf essential oil reduces orofacial nociception in mice - evidence of possible involvement of descending inhibitory pain modulation pathway.
Topics: Animals; beta-Cyclodextrins; Capsaicin; Facial Pain; Formaldehyde; Glutamic Acid; Lippia; Male; Mice; Morphine; Nociception; Oils, Volatile; Pain Measurement; Periaqueductal Gray; Plant Leaves | 2014 |
Antinociceptive activity of a synthetic oxopyrrolidine-based compound, ASH21374, and determination of its possible mechanisms.
Topics: Analgesics; Analgesics, Opioid; Animals; Aspirin; Capsaicin; Cyclic GMP; Glutamic Acid; Male; Mice; Mice, Inbred BALB C; Morphine; Motor Activity; Naloxone; Naltrexone; Nitric Oxide; Pyrrolidines; Rats, Sprague-Dawley; Receptors, Opioid | 2013 |
Antioxidant and orofacial anti-nociceptive activities of the stem bark aqueous extract of Anadenanthera colubrina (Velloso) Brenan (Fabaceae).
Topics: Amidines; Analgesics; Animals; Antioxidants; Biphenyl Compounds; Capsaicin; Colubrina; Fabaceae; Glutamic Acid; Lipid Peroxidation; Male; Mice; Pain; Pain Measurement; Phytotherapy; Picrates; Plant Bark; Plant Extracts; Plant Stems | 2014 |
Anti-inflammatory and antinociceptive effects of Sterculia striata A. St.-Hil. & Naudin (Malvaceae) in rodents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Carrageenan; Dextrans; Edema; Formaldehyde; Glutamic Acid; Histamine; Inflammation; Male; Mice; Naloxone; Pain; Phytotherapy; Plant Bark; Plant Extracts; Plant Stems; Rats, Wistar; Sterculia | 2014 |
Antinociceptive esters of N-methylanthranilic acid: Mechanism of action in heat-mediated pain.
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Formaldehyde; Glutamic Acid; Hot Temperature; KATP Channels; Male; Mice; Motor Activity; Narcotic Antagonists; Neurotransmitter Agents; ortho-Aminobenzoates; Pain; Pain Perception; Pain Threshold; Potassium Channel Blockers; Reaction Time; Time Factors | 2014 |
Intradermal glutamate and capsaicin injections: intra- and interindividual variability of provoked hyperalgesia and allodynia.
Topics: Adolescent; Adult; Capsaicin; Glutamic Acid; Humans; Hyperalgesia; Injections, Intradermal; Male; Pain Measurement; Physical Stimulation; Reproducibility of Results; Sensory System Agents; Touch; Young Adult | 2014 |
Citral: a monoterpene with prophylactic and therapeutic anti-nociceptive effects in experimental models of acute and chronic pain.
Topics: Acute Pain; Acyclic Monoterpenes; Analgesics; Animals; Capsaicin; Chronic Pain; Excitatory Amino Acids; Formaldehyde; Glutamic Acid; Hyperalgesia; Ischemia; Ketanserin; Male; Mice; Monoterpenes; Neuralgia; Pain, Postoperative; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Serotonin 5-HT2 Receptor Antagonists; Stomach Ulcer; Substance P; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2014 |
Cannabinoid 1 and transient receptor potential vanilloid 1 receptors discretely modulate evoked glutamate separately from spontaneous glutamate transmission.
Topics: Action Potentials; Analgesics; Animals; Arachidonic Acids; Benzoxazines; Brain Stem; Capsaicin; Dopamine; Excitatory Postsynaptic Potentials; Glutamic Acid; Hot Temperature; In Vitro Techniques; Male; Morpholines; Naphthalenes; Neurons; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Synaptic Transmission; TRPV Cation Channels | 2014 |
Effects of the calcium channel blockers Phα1β and ω-conotoxin MVIIA on capsaicin and acetic acid-induced visceral nociception in mice.
Topics: Acetic Acid; Administration, Rectal; Animals; Calcium Channel Blockers; Capsaicin; Dose-Response Relationship, Drug; Glutamic Acid; Injections, Spinal; Male; Mice; Nociception; omega-Conotoxins; Reactive Oxygen Species; Spider Venoms | 2014 |
Carvacrol presynaptically enhances spontaneous excitatory transmission and produces outward current in adult rat spinal substantia gelatinosa neurons.
Topics: Acetanilides; Analgesics; Animals; Capsaicin; Cymenes; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Monoterpenes; Neurons; Neurotransmitter Agents; Nociception; Patch-Clamp Techniques; Permeability; Potassium; Potassium Channel Blockers; Purines; Rats, Sprague-Dawley; Substantia Gelatinosa; Tissue Culture Techniques; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels | 2014 |
Inflammatory pain models with capsaicin or glutamate injections: are they comparable and reproducible?
Topics: Capsaicin; Glutamic Acid; Humans; Inflammation; Pain; Reproducibility of Results | 2014 |
Mechanisms of α-mangostin-induced antinociception in a rodent model.
Topics: Analgesics; Animals; Arginine; Capsaicin; Disease Models, Animal; Glutamic Acid; Male; Mice; Mice, Inbred ICR; NG-Nitroarginine Methyl Ester; Rats; Xanthones | 2015 |
Inhibitors of glutamate release from breast cancer cells; new targets for cancer-induced bone-pain.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Bone and Bones; Breast Neoplasms; Capsaicin; Cell Line, Tumor; Dopamine Agonists; Drug Discovery; Female; Glutamic Acid; High-Throughput Screening Assays; Humans; Inhibitory Concentration 50; Pain; Signal Transduction; Small Molecule Libraries | 2015 |
Spontaneous L-glutamate release enhancement in rat substantia gelatinosa neurons by (-)-carvone and (+)-carvone which activate different types of TRP channel.
Topics: Acetanilides; Animals; Capsaicin; Cyclohexane Monoterpenes; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Monoterpenes; Neurons; Patch-Clamp Techniques; Purines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Substantia Gelatinosa; Synaptic Transmission; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels | 2015 |
Down-regulation of astroglial glutamate transporter-1 in the locus coeruleus impairs pain-evoked endogenous analgesia in rats.
Topics: Analgesia; Animals; Astrocytes; Capsaicin; Down-Regulation; Excitatory Amino Acid Transporter 2; Gene Knockdown Techniques; Glutamic Acid; Locus Coeruleus; Male; Neurons; Norepinephrine; Pain; Pain Threshold; Rats, Sprague-Dawley; RNA, Small Interfering; Spinal Cord | 2015 |
Vanilloids selectively sensitize thermal glutamate release from TRPV1 expressing solitary tract afferents.
Topics: Animals; Capsaicin; Diterpenes; Electric Stimulation; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Male; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sensory System Agents; Sodium Channel Blockers; Solitary Nucleus; Synaptic Transmission; Tetrodotoxin; TRPV Cation Channels | 2016 |
Postnatal Excitability Development and Innervation by Functional Transient Receptor Potential Vanilloid 1 (TRPV1) Terminals in Neurons of the Rat Spinal Sacral Dorsal Commissural Nucleus: an Electrophysiological Study.
Topics: Action Potentials; Animals; Animals, Newborn; Capsaicin; Electrophysiological Phenomena; Excitatory Postsynaptic Potentials; Glutamic Acid; Nerve Fibers, Unmyelinated; Neurons; Presynaptic Terminals; Rats, Sprague-Dawley; Sacrum; Spinal Cord; TRPV Cation Channels | 2016 |
Antinociceptive effects of the aqueous and methanol extracts of the leaves of Pittosporum mannii Hook. F. (Pittosporaceae) in mice.
Topics: Acetic Acid; Analgesics; Animals; Artemia; Capsaicin; Female; Formaldehyde; Glutamic Acid; Hot Temperature; Larva; Lethal Dose 50; Male; Methanol; Mice; Motor Activity; Pain; Phytochemicals; Phytotherapy; Plant Extracts; Plant Leaves; Rosales; Rotarod Performance Test; Solvents; Water | 2016 |
The Bisphosphonates Clodronate and Etidronate Exert Analgesic Effects by Acting on Glutamate- and/or ATP-Related Pain Transmission Pathways.
Topics: Acetic Acid; Adenosine Triphosphate; Analgesics; Animals; Bone Density Conservation Agents; Capsaicin; Clodronic Acid; Etidronic Acid; Excitatory Amino Acid Agonists; Foscarnet; Glutamic Acid; Lumbar Vertebrae; Mice; Mice, Inbred BALB C; N-Methylaspartate; Pain; Sodium-Phosphate Cotransporter Proteins; Spinal Cord; Substance P | 2016 |
Evidence for the involvement of TNF-α and IL-1β in the antinociceptive and anti-inflammatory activity of Stachys lavandulifolia Vahl. (Lamiaceae) essential oil and (-)-α-bisabolol, its main compound, in mice.
Topics: Analgesics; Animals; Anti-Infective Agents; Capsaicin; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Facial Pain; Flame Ionization; Formaldehyde; Gas Chromatography-Mass Spectrometry; Glutamic Acid; Interleukin-1beta; Male; Mice; Monocyclic Sesquiterpenes; Nociception; Nociceptive Pain; Oils, Volatile; Phytotherapy; Plant Extracts; Plant Oils; Plants, Medicinal; Pleurisy; Sesquiterpenes; Stachys; Time Factors; Tumor Necrosis Factor-alpha | 2016 |
Antinociceptive Effect of 3-(2,3-Dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in Mice Models of Induced Nociception.
Topics: Analgesics; Animals; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Furans; Glutamic Acid; Injections, Intraperitoneal; Ketones; Male; Mice; Nociception; Nociceptive Pain | 2016 |
Presynaptic facilitation by tetracaine of glutamatergic spontaneous excitatory transmission in the rat spinal substantia gelatinosa - Involvement of TRPA1 channels.
Topics: Acetanilides; Amides; Anesthetics, Local; Animals; Bupivacaine; Capsaicin; Excitatory Postsynaptic Potentials; Glutamic Acid; Levobupivacaine; Male; Neurotransmitter Agents; Pain; Patch-Clamp Techniques; Presynaptic Terminals; Prilocaine; Purines; Pyrazines; Pyridines; Rats, Sprague-Dawley; Ropivacaine; Ruthenium Red; Substantia Gelatinosa; Tetracaine; Tetrodotoxin; Tissue Culture Techniques; TRPA1 Cation Channel; TRPC Cation Channels | 2017 |
Enhanced ability of TRPV1 channels in regulating glutamatergic transmission after repeated morphine exposure in the nucleus accumbens of rat.
Topics: Animals; Capsaicin; Corpus Striatum; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Morphine; Narcotics; Neuronal Plasticity; Neurotransmitter Agents; Nucleus Accumbens; Piperidines; Presynaptic Terminals; Pyrazoles; Random Allocation; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Substance Withdrawal Syndrome; Synaptic Transmission; Tissue Culture Techniques; TRPV Cation Channels | 2017 |
Capsaicin protects cortical neurons against ischemia/reperfusion injury via down-regulating NMDA receptors.
Topics: Animals; Behavior, Animal; Capsaicin; Cells, Cultured; Down-Regulation; Excitatory Amino Acids; Glutamic Acid; Infarction, Middle Cerebral Artery; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; TRPV Cation Channels | 2017 |
Orofacial antinociceptive effect of Mimosa tenuiflora (Willd.) Poiret.
Topics: Acrolein; Analgesics; Animals; Antioxidants; Capsaicin; Chemical Fractionation; Chlorocebus aethiops; Ethanol; Facial Pain; Glutamic Acid; Glyburide; Mice; Mimosa; Motor Activity; Naloxone; NG-Nitroarginine Methyl Ester; Nociception; Phenols; Plant Extracts; Rats, Wistar; Temporomandibular Joint; Vero Cells | 2018 |
New
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Coffee; Disease Models, Animal; Female; Formaldehyde; Glutamic Acid; Hot Temperature; Hyperalgesia; Male; Mice; Naloxone; Narcotic Antagonists; Ondansetron; Pain; Pain Measurement; Piperidines; Pyrazoles; Serotonin | 2018 |
Effects of isopulegol in acute nociception in mice: Possible involvement of muscarinic receptors, opioid system and l-arginine/NO/cGMP pathway.
Topics: Acute Disease; Administration, Oral; Analgesics; Animals; Arginine; Behavior, Animal; Capsaicin; Cyclic GMP; Cyclohexane Monoterpenes; Female; Formaldehyde; Glutamic Acid; Male; Mice; Nitric Oxide; Pain; Receptors, Muscarinic; Receptors, Opioid; Signal Transduction; Terpenes | 2018 |
Attenuation of glutamatergic and nitrergic system contributes to the antidepressant-like effect induced by capsazepine in the forced swimming test.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antidepressive Agents; Apomorphine; Arginine; Capsaicin; Cyclic GMP; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Enzyme Inhibitors; Exploratory Behavior; Glutamic Acid; Male; Microinjections; Nitric Oxide; Nitroprusside; Rats; Receptors, N-Methyl-D-Aspartate; Statistics, Nonparametric; Swimming | 2019 |
Phoneutria toxin PnTx3-5 inhibits TRPV1 channel with antinociceptive action in an orofacial pain model.
Topics: Acrolein; Anilides; Animals; Calcium; Calcium Signaling; Capsaicin; Cinnamates; Disease Models, Animal; Facial Pain; Glutamic Acid; HEK293 Cells; Humans; Inhibitory Concentration 50; Male; Neuropeptides; Nociception; Patch-Clamp Techniques; Rats; Sensory System Agents; Transfection; Trigeminal Ganglion; TRPA1 Cation Channel; TRPV Cation Channels | 2020 |
Analgesic effects of the CTK 01512-2 toxin in different models of orofacial pain in rats.
Topics: Analgesics; Animals; Calcium Channels, N-Type; Capsaicin; Disease Models, Animal; Facial Pain; Freund's Adjuvant; Glutamic Acid; Hyperalgesia; Male; Neuralgia; omega-Conotoxins; Pain Measurement; Rats; Rats, Wistar; TRPA1 Cation Channel | 2020 |
Differential modulation of the contextual conditioned emotional response by CB1 and TRPV1 receptors in the ventromedial prefrontal cortex: Possible involvement of NMDA/nitric oxide-related mechanisms.
Topics: Animals; Behavior, Animal; Capsaicin; Conditioning, Classical; Fear; Glutamic Acid; Male; Nitric Oxide; Nitric Oxide Synthase; Nitrosamines; Prefrontal Cortex; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, N-Methyl-D-Aspartate; TRPV Cation Channels | 2020 |
Pain Perception, Brain Connectivity, and Neurochemistry in Healthy, Capsaicin-Sensitive Subjects.
Topics: Adult; Brain; Capsaicin; Female; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Male; Neural Pathways; Nociception; Pain Perception; Young Adult | 2020 |
Inhibition of Spinal TRPV1 Reduces NMDA Receptor 2B Phosphorylation and Produces Anti-Nociceptive Effects in Mice with Inflammatory Pain.
Topics: Analgesics; Animals; Capsaicin; Carrageenan; Disease Models, Animal; Glutamic Acid; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred ICR; Pain; Phosphorylation; Receptors, N-Methyl-D-Aspartate; Spinal Cord; TRPV Cation Channels | 2021 |
Evaluation of the systemic and spinal antinociceptive effect of a new hybrid NSAID tetrahydropyran derivative.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Gene Expression Regulation; Glutamic Acid; Hot Temperature; Humans; Male; Mice; Pain; Pyrans | 2022 |
Orofacial antinociceptive effects of perillyl alcohol associated with codeine and its possible modes of action.
Topics: Analgesics; Animals; Capsaicin; Codeine; Facial Pain; Glutamic Acid; Mice; Molecular Docking Simulation; Monoterpenes; Receptors, Glutamate | 2022 |