glutamic acid and calpain

glutamic acid has been researched along with calpain in 113 studies

Research

Studies (113)

TimeframeStudies, this research(%)All Research%
pre-19903 (2.65)18.7374
1990's9 (7.96)18.2507
2000's52 (46.02)29.6817
2010's42 (37.17)24.3611
2020's7 (6.19)2.80

Authors

AuthorsStudies
Costa, E; Favaron, M; Guidotti, A; Manev, H; Siman, R1
Christoph, G; Siman, R1
Mellgren, RL1
Baudry, M; Lynch, G1
Brorson, JR; Marcuccilli, CJ; Miller, RJ1
Coutts, CT; Foster, J; Gyte, A; Upton, R; Widdowson, PS; Wyatt, I1
Ferger, D; Krieglstein, J; Rami, A1
Aman, MJ; Henkart, PA; Leonard, WJ; Nakajima, H; Noguchi, M; Sarin, A; Shores, EW1
Adamec, E; Beermann, ML; Nixon, RA1
Baudry, M; Bi, X; Chen, J; Dang, S; Rong, Y; Wang, Z1
Arthur, JS; Croall, DE; Dutt, P; Elce, JS1
Gurd, JW; Lombroso, PJ; Nguyen, TH; Paul, S; Xu, Y1
Crossin, KL; Edelman, GM; Gally, JA; Holst, BH; Krushel, LA; Vanderklish, PW1
d'Avella, D; Hayes, RL; Newcomb, JK; Pike, BR; Wang, KK; Zhao, X1
Friedlander, RM; Kwon, YT; Lee, MS; Li, M; Peng, J; Tsai, LH1
Davies, PL; Elce, JS; Hosfield, CM; Jia, Z; Moldoveanu, T1
Flood, DG; Lin, YG; Reaume, AG; Savage, MJ; Scott, RW; Siman, R; Trusko, S1
Hirai, H1
Patzke, H; Tsai, LH1
Cattaneo, E; De Micheli, A; Goffredo, D; Matteoli, M; Rigamonti, D; Tartari, M; Verderio, C; Zuccato, C1
Kerokoski, P; Pirttilä, T; Salminen, A; Soininen, H; Suuronen, T1
Agerholm-Larsen, B; Chen, W; Linsel-Nitschke, P; Martinez, LO; Silver, DL; Tall, AR; Wang, N1
Elce, JS; Huynh, KK; Jia, Z; Smith, SD; Wells, A1
Bondada, V; Geddes, JW; Pang, Z; Sengoku, T; Siman, R1
Li, ST; Lu, YF; Matsui, H; Matsushita, M; Moriwaki, A; Oda, Y; Tomizawa, K; Wei, FY; Wu, HY1
Chen, Z; Dong, Y; Guttmann, RP; Lynch, DR; Neumar, RW; Simpkins, KL; Sokol, S1
Potrovita, I; Prinz, S; Schölzke, MN; Schwaninger, M; Subramaniam, S1
Banik, NL; Li, L; Nowak, MW; Ray, SK; Sribnick, EA1
Axelsen, PH; Englander, SW; Giasson, BI; Graves, CL; Greenbaum, EA; Lupoli, MA; Lynch, DR; Mishizen-Eberz, AJ1
Bantubungi, K; Blum, D; Brotchi, J; Brouillet, E; Chtarto, A; Déglon, N; Galas, MC; Greco, A; Jacquard, C; Levivier, M; Minghetti, L; Pintor, A; Popoli, P; Schiffmann, SN; Tai, K; Tenenbaum, L1
Lu, YF; Matsui, H; Matsushita, M; Tomizawa, K; Wu, HY; Yan, Z; Yuen, EY1
Appel, SH; Banik, NL; Das, A; Del Re, AM; Ray, SK; Sribnick, EA; Wingrave, JM; Woodward, JJ1
Ando, K; Kudo, Y; Takahashi, M1
Chen, JQ; Chen, RH; Chi, X; Fei, L; Guo, M; Guo, XR; Huang, SM; Lu, C; Pan, XQ; Wu, SH; Zhao, F1
Brunette, E; Hou, ST; Jiang, SX; Konishi, Y; Lertvorachon, J; Mealing, G; Preston, E; Tauskela, J; Webster, J1
Auberson, YP; DeRidder, MN; Meaney, DF; Raghupathi, R; Siman, R; Simon, MJ1
Desbois, A; Hou, ST; Huang, D; Jiang, SX; Kappler, J; Karchewski, L; Kelly, J; Tessier, L1
Banik, NL; Karmakar, S; Nowak, MW; Ray, SK1
Bhavnani, BR; Zhang, Y1
Bretin, S; Gauchy, C; Glowinski, J; Honnorat, J; Marin, P; Maus, M; Prémont, J; Rogemond, V; Torrens, Y1
Akashiba, H; Matsuki, N; Nishiyama, N1
Jin, Y; Lee, YH; Lin, CH; Wei, J; Wu, H; Wu, JY1
Goldberg, MP; Underhill, SM1
Cianci, CD; Glantz, SB; Iyer, R; Morrow, JS; Pradhan, D; Wang, KK1
Dluzen, DE; Jin, Y; Li, N; Liu, B1
Barger, SW; Mao, X; Simpkins, JW; Yang, SH1
Avila, J; Goñi-Oliver, P; Hernández, F; Lucas, JJ1
Baker, AJ; Bell, JD; Park, E1
Del Río, P; Massieu, L1
Kanazawa, Y; Makino, M; Morishima, Y; Nabeshima, T; Shirasaki, Y; Yamada, K1
Liu, J; Liu, MC; Wang, KK1
Le Roux, PD; Monnerie, H1
Elphick, LM; Eriksson, JE; Hawat, M; Kass, GE; Meinander, A; Mikhailov, A; Toms, NJ1
Antonucci, F; Berghuis, P; Bonanno, G; Caleo, M; Carmignoto, G; Dobszay, MB; Grumelli, C; Harkany, T; Matteoli, M; Pozzi, D; Verderio, C1
Bagetta, G; Cavaliere, F; Cerulli, A; Corasaniti, MT; Fazzi, E; Gliozzi, M; Morrone, LA; Nucci, C; Rombolà, L; Russo, R1
Buddhala, C; Jin, Y; Leon, R; Prentice, H; Wei, J; Wu, H; Wu, JY1
Baudry, M; Bi, X; Cheung, S; Galeano, J; Liao, G; Nguyen, N; Zhou, M1
Behl, C; Hajieva, P; Kuhlmann, C; Luhmann, HJ1
Campos-Esparza, MR; Matute, C; Sánchez-Gómez, MV1
Jin, Y; Lee, HH; Lee, YH; Lin, CH; Prentice, H; Sha, D; Wei, J; Wu, H; Wu, JY; Yang, LL1
Clarke, PG; Delacourte, A; Grishchuk, Y; Hirling, H; Luthi-Carter, R; Puyal, J; Rudinskiy, N; Vaslin, A1
Banik, NL; Del Re, AM; Ray, SK; Sribnick, EA; Woodward, JJ1
Divakaruni, AS; Gerencser, AA; Hubbard, AE; Mark, KA; Mehrabian, Z; Nicholls, DG; Polster, BM1
Baum, ML; Bibb, JA; Goebel-Goody, SM; Hawasli, AH; Kurup, P; Lombroso, PJ; Wu, PH; Xu, J; Zhang, Y1
Bano, D; Cabrera-Socorro, A; Dinsdale, D; Ferrando-May, E; Hengartner, MO; Lambacher, N; Maida, S; McColl, B; Nicotera, P1
Deng, P; Lei, Z; Li, Y; Xu, ZC1
Bolshakov, A; Brustovetsky, N; Brustovetsky, T1
Lau, A; Tymianski, M1
Chang, KH; de Pablo, Y; Lee, HG; Lee, HP; Shah, K; Smith, MA1
Andriessen, TM; Jacobs, B; Vos, PE1
Coulter, DA; Hsu, FC; Le Roux, PD; Monnerie, H1
Garg, S; Mandelkow, E; Mandelkow, EM; Timm, T; Wang, Y1
Baig, I; Guttmann, RP; Levine, H; Mohmmad Abdul, H; Norris, CM1
Czotter, N; Dénes, V; Gábriel, R; Lakk, M1
Aihara, M; Araie, M; Chen, YN; Iwashina, T; Nakayama, M; Tomita-Yokotani, K1
Bahr, BA; Carvalho, AL; Catarino, T; Duarte, CB; Fernandez, P; Gomes, JR; Inácio, AR; Lobo, AC; Mele, M; Santos, AE; Wieloch, T1
Estrada-Sánchez, AM; Guemez-Gamboa, A; Massieu, L; Montiel, T; Morán, J; Páramo, B1
Breuer, P; Brüstle, O; Doerr, J; Evert, BO; Hoffmann, P; Jungverdorben, J; Kesavan, J; Klockgether, T; Koch, P; Ladewig, J; Mertens, J; Peitz, M; Poppe, D; Tüting, T; Wüllner, U1
Almeida, RD; Costa, JT; Duarte, CB; Felizzi, F; Gomes, JR; Grãos, M; Inácio, AR; Melo, CV; Monteiro, P; Pinto, MJ; Wieloch, T1
Chen, M; Maleski, JJ; Nguyen, HT; Sawmiller, DR; Wu, Q1
Barateiro, A; Brites, D; Fernandes, A; Silva, SL; Vaz, AR1
Byun, HS; Chen, H; Chen, SR; Han, HD; Li, L; Lopez-Berestein, G; Pan, HL; Sood, AK; Zhou, HY1
Chen, J; Dong, LD; Hu, XC; Miao, Y; Wang, Z; Yang, XL1
Bahr, BA; Baptista, MS; Duarte, CB; Frommer, WB; Gomes, JR; Melo, CV; Okumoto, S1
Baek, JU; Choi, BT; Choi, YH; Choi, YW; Hong, JW; Jang, JY; Kim, HN; Kim, YR; Shin, HK1
Halpin, LE; Northrop, NA; Yamamoto, BK1
Bae, DW; Choi, BT; Choi, YW; Hong, JW; Jang, JY; Kim, HN; Kim, YR; Park, SJ; Shin, HK1
Abrouk-Vérot, L; Bouchot, C; Brun, C; Exbrayat, JM; Moudilou, E1
Chen, M; Nguyen, HT1
Blum, D; Buée-Scherrer, V; Caetano, AP; Castrén, E; Diógenes, MJ; Jerónimo-Santos, A; Parreira, S; Rapaz-Lérias, S; Sebastião, AM; Valente, CA; Vaz, SH1
Fujioka, H; Li, L; Liu, Y; Pi, Y; Siedlak, SL; Su, B; Tang, F; Wang, W; Wang, X; Zhang, F1
Barbon, A; Bonini, D; Colombi, M; Filippini, A; Fiorentini, C; Fumagalli, F; La Via, L1
Canzoniero, LM; Curcio, M; Duarte, CB; Duarte, EP; Inácio, AR; Salazar, IL1
Chen, FQ; Chen, X; Chen, XD; Ding, ZJ; Lin, Y; Mi, WJ; Qiu, JH; Song, YL; Tang, XX; Wang, J; Wang, X1
Chen, FQ; Chen, X; Chen, XD; Ding, ZJ; Mi, WJ; Qiu, JH; Song, YL; Tang, XX; Wang, J; Wang, RF; Wang, X1
Baptista, MS; Costa, JT; de Almeida, LP; Duarte, CB; Gomes, JR; Mele, M; Nobre, RJ; Ruscher, K; Wieloch, T1
Arunakaran, J; Bavithra, S; Krishnamoorthy, G; Selvakumar, K; Sugantha Priya, E1
Bach, JP; Dodel, R; Dontcheva, G; Gold, M; Habib, P; Koczulla, AR; Koepke, J; Mengel, D1
Chen, W; Leng, T; Li, Y; Lin, S; Lu, B; Qiu, P; Tang, L; Yan, G; Yan, M; Yin, W; Zheng, X; Zhu, W1
Gu, XM; Jin, ZX; Kong, LH; Lai, D; Zhang, JY; Zhou, JJ1
Boguszewski, PM; Domin, H; Jantas, D; Kozniewska, E; Przykaza, Ł; Śmiałowska, M1
Guekht, AB; Gulyaeva, NV; Khaspekov, LG; Lyzhin, AA; Yakovlev, AA1
Jeon, YJ; Kim, WY; Lee, JS; Lee, SK; Son, CG1
Chen, D; Huang, J; Huang, Y; Ji, D; Liao, L; Liu, F; Wang, M; Wang, S; Wang, Z; Xia, X; Xiong, K; Yan, Y; Zhou, H1
Ahmed, M; Hwang, JS; Kim, DR; Lai, TH; Nguyen, HQ; Pham, TM; Zada, S1
Díaz-Guerra, M; Gamir-Morralla, A; Iglesias, T; López-Menéndez, C; Luján, R; Mochizuki, N; Pose-Utrilla, J; Simón-García, A1
Hatta, D; Hori, Y; Iwata, N; Kurotaki, N; Shirotani, K1
Kim, WK; Ko, YU; Oh, YJ; Song, HY; Yun, N; Yune, TY1
Fukuda, T; Oikawa, T; Ozaki, T; Tomita, H; Yamashita, T1
Arze, R; Hudson, D; Mark, KA; Polster, BM1
Huang, JF; Liao, LS; Liu, SM; Wang, SC1
Abdallah, DM; El-Abhar, HS; Fayez, AM; Mohamed, OE; Mohamed, RA1
Ameen, SS; Ang, CS; Basheer, F; Bokhari, L; Cheng, HC; Ciccotosto, GD; Clarkson, AN; Dhillon, A; Draxler, DF; Dufour, A; Griem-Krey, N; Hoque, A; Hossain, MI; Kamaruddin, MA; Kleifeld, O; Leeming, MG; Lim, JP; Liu, D; Lucet, IS; Medcalf, RL; Nandurkar, H; Paradkar, PN; Roulston, CL; Sturgeon, S; Wellendorph, P; Williamson, NA; Zhu, HJ1

Reviews

4 review(s) available for glutamic acid and calpain

ArticleYear
Calcium-dependent proteases: an enzyme system active at cellular membranes?
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1987, Volume: 1, Issue:2

    Topics: Calcium; Calpain; Cell Fusion; Enzyme Activation; Glutamates; Glutamic Acid; Isoenzymes; Membrane Proteins; Memory; Protein Kinase C

1987
Traumatic brain injury: can the consequences be stopped?
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2008, Apr-22, Volume: 178, Issue:9

    Topics: Animals; Axons; Biomarkers; Brain Edema; Brain Injuries; Calcium; Calpain; Diffuse Axonal Injury; Glutamic Acid; Humans; Intracranial Hypertension; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate

2008
Glutamate receptors, neurotoxicity and neurodegeneration.
    Pflugers Archiv : European journal of physiology, 2010, Volume: 460, Issue:2

    Topics: Animals; Antioxidants; Calcium; Calpain; Caspases; Cell Death; Free Radical Scavengers; Free Radicals; Glutamic Acid; Humans; Hypothalamus; Nerve Degeneration; Neurodegenerative Diseases; Neurotoxicity Syndromes; Nitric Oxide; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Sodium-Calcium Exchanger; Zinc

2010
Clinical characteristics and pathophysiological mechanisms of focal and diffuse traumatic brain injury.
    Journal of cellular and molecular medicine, 2010, Volume: 14, Issue:10

    Topics: Brain Edema; Brain Injuries; Calpain; Caspases; Diffuse Axonal Injury; Excitatory Amino Acids; Glasgow Coma Scale; Glutamic Acid; Humans; Injury Severity Score; Magnetic Resonance Imaging; Mitochondria; Necrosis; Neurotransmitter Agents

2010

Other Studies

109 other study(ies) available for glutamic acid and calpain

ArticleYear
Glutamate neurotoxicity is independent of calpain I inhibition in primary cultures of cerebellar granule cells.
    Journal of neurochemistry, 1991, Volume: 57, Issue:4

    Topics: Animals; Animals, Newborn; Calcium; Calpain; Cell Survival; Cells, Cultured; Cerebellum; Gangliosides; Glutamates; Glutamic Acid; Granulocytes; Nervous System; Neurons; Osmolar Concentration; Spectrin

1991
beta-Amyloid precursor is a PEST protein.
    Biochemical and biophysical research communications, 1989, Dec-29, Volume: 165, Issue:3

    Topics: Amino Acid Sequence; Amyloid; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Brain Chemistry; Calpain; Glutamates; Glutamic Acid; Molecular Sequence Data; Proline; Protease Inhibitors; Protein Precursors; Rats; Serine; Threonine

1989
The biochemistry of memory: a new and specific hypothesis.
    Science (New York, N.Y.), 1984, Jun-08, Volume: 224, Issue:4653

    Topics: Animals; Calcium; Calpain; Carrier Proteins; Cerebral Cortex; Endopeptidases; Glutamates; Glutamic Acid; Hippocampus; Humans; Learning; Leupeptins; Memory; Microfilament Proteins; Neuronal Plasticity; Rabbits; Rats; Receptors, Cell Surface; Receptors, Glutamate; Receptors, Neurotransmitter; Synapses; Synaptic Membranes; Telencephalon

1984
Delayed antagonism of calpain reduces excitotoxicity in cultured neurons.
    Stroke, 1995, Volume: 26, Issue:7

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Calpain; Cell Survival; Cells, Cultured; Cerebellum; Dipeptides; Enzyme Activation; Glutamic Acid; Hippocampus; Kainic Acid; Leucine; N-Methylaspartate; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitroarginine; Rats; Receptors, N-Methyl-D-Aspartate; Spectrin; Time Factors

1995
Calpain activation and not oxidative damage mediates L-2-chloropropionic acid-induced cerebellar granule cell necrosis.
    Toxicology and applied pharmacology, 1997, Volume: 142, Issue:2

    Topics: Administration, Oral; Animals; Antioxidants; Ascorbic Acid; Aspartic Acid; Blotting, Western; Calpain; Cerebellum; Free Radicals; Glutamic Acid; Hydrocarbons, Chlorinated; Lipid Peroxidation; Male; Necrosis; Nervous System Diseases; Neurons; Oxidative Stress; Propionates; Rats; Spectrin

1997
Blockade of calpain proteolytic activity rescues neurons from glutamate excitotoxicity.
    Neuroscience research, 1997, Volume: 27, Issue:1

    Topics: Animals; Calpain; Cells, Cultured; Cysteine Proteinase Inhibitors; Dipeptides; Glutamic Acid; Glycoproteins; Hippocampus; Leucine; Neurons; Neuroprotective Agents; Neurotoxins; Rats

1997
Functional cleavage of the common cytokine receptor gamma chain (gammac) by calpain.
    Proceedings of the National Academy of Sciences of the United States of America, 1997, Oct-14, Volume: 94, Issue:21

    Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Calpain; CD4-Positive T-Lymphocytes; Cells, Cultured; DNA Primers; Glutamic Acid; Humans; Interleukin-2; Ionomycin; Lymphocyte Activation; Macromolecular Substances; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutagenesis, Site-Directed; Polymerase Chain Reaction; Proline; Protein Biosynthesis; Receptor-CD3 Complex, Antigen, T-Cell; Receptors, Cytokine; Recombinant Proteins; Sequence Alignment; Serine; Signal Transduction; Substrate Specificity; T-Lymphocytes; Threonine

1997
Calpain I activation in rat hippocampal neurons in culture is NMDA receptor selective and not essential for excitotoxic cell death.
    Brain research. Molecular brain research, 1998, Volume: 54, Issue:1

    Topics: Animals; Calcium; Calpain; Cell Death; Cells, Cultured; Embryo, Mammalian; Enzyme Activation; Glutamic Acid; Hippocampus; Neurons; Neurotoxins; Rats; Receptors, N-Methyl-D-Aspartate

1998
Calpain-mediated regulation of NMDA receptor structure and function.
    Brain research, 1998, Apr-20, Volume: 790, Issue:1-2

    Topics: Animals; Calcium; Calpain; Cysteine Proteinase Inhibitors; Dipeptides; Enzyme Activation; Excitatory Amino Acid Agonists; Freezing; Glutamic Acid; Hippocampus; Ion Channel Gating; Kainic Acid; Neuronal Plasticity; Organ Culture Techniques; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes

1998
m-Calpain subunits remain associated in the presence of calcium.
    FEBS letters, 1998, Oct-09, Volume: 436, Issue:3

    Topics: Alanine; Animals; Calcium; Calpain; Caseins; Catalytic Domain; Cattle; Cysteine; Dimerization; Glutamic Acid; Kinetics; Macromolecular Substances; Mutagenesis, Site-Directed; Protein Binding; Recombinant Proteins; Serine

1998
Calcium-dependent cleavage of striatal enriched tyrosine phosphatase (STEP).
    Journal of neurochemistry, 1999, Volume: 73, Issue:5

    Topics: Animals; Calcimycin; Calcium; Calpain; Dipeptides; Egtazic Acid; Female; Glutamic Acid; Ionophores; Isoenzymes; Kinetics; Molecular Weight; Protein Tyrosine Phosphatases; Protein Tyrosine Phosphatases, Non-Receptor; Rats; Rats, Long-Evans; Thapsigargin; Transfection

1999
Marking synaptic activity in dendritic spines with a calpain substrate exhibiting fluorescence resonance energy transfer.
    Proceedings of the National Academy of Sciences of the United States of America, 2000, Feb-29, Volume: 97, Issue:5

    Topics: Amino Acid Sequence; Animals; Biomarkers; Calcium; Calpain; COS Cells; Culture Techniques; Dendrites; Energy Transfer; Fluorescence; Glutamic Acid; Green Fluorescent Proteins; Hippocampus; Intracellular Fluid; Long-Term Potentiation; Luminescent Proteins; Microscopy, Fluorescence; Molecular Sequence Data; N-Methylaspartate; Rats; Receptors, Glutamate; Recombinant Fusion Proteins; Spectrin; Spectrometry, Fluorescence; Substrate Specificity; Synaptic Transmission

2000
Novel characteristics of glutamate-induced cell death in primary septohippocampal cultures: relationship to calpain and caspase-3 protease activation.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2000, Volume: 20, Issue:3

    Topics: Animals; Calpain; Caspase 3; Caspases; Cell Death; Cells, Cultured; Coculture Techniques; Enzyme Activation; Fetus; Glutamic Acid; Hippocampus; Neuroglia; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Septum Pellucidum; Spectrin

2000
Neurotoxicity induces cleavage of p35 to p25 by calpain.
    Nature, 2000, May-18, Volume: 405, Issue:6784

    Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Calcium; Calpain; Cells, Cultured; Egtazic Acid; Glutamic Acid; Hydrogen Peroxide; Ionomycin; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Nerve Tissue Proteins; Neurons; Peptide Fragments; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Recombinant Proteins

2000
Calpain mutants with increased Ca2+ sensitivity and implications for the role of the C(2)-like domain.
    The Journal of biological chemistry, 2001, Mar-09, Volume: 276, Issue:10

    Topics: Animals; Calcium; Calpain; Crystallography, X-Ray; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Glutamic Acid; Lysine; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Point Mutation; Protein Binding; Protein Conformation; Protein Isoforms; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Salts; Serine

2001
Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Dec-01, Volume: 20, Issue:23

    Topics: Alzheimer Disease; Amino Acid Substitution; Amyloid; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Apoptosis; Calpain; Caspases; Cell Survival; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Gene Targeting; Glutamic Acid; Homozygote; Membrane Proteins; Mice; Mice, Mutant Strains; Mice, Transgenic; Neurons; Peptide Fragments; Presenilin-1; Staurosporine

2000
Ca2+-dependent regulation of synaptic delta2 glutamate receptor density in cultured rat Purkinje neurons.
    The European journal of neuroscience, 2001, Volume: 14, Issue:1

    Topics: Actins; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Calpain; Cells, Cultured; Cerebellum; Cycloleucine; Dendrites; Endocytosis; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Intracellular Fluid; Neuroprotective Agents; Purkinje Cells; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Synaptic Membranes; Synaptic Transmission

2001
Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29.
    The Journal of biological chemistry, 2002, Mar-08, Volume: 277, Issue:10

    Topics: Animals; Blotting, Western; Brain; Calcium; Calpain; Carrier Proteins; COS Cells; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; DNA; Dose-Response Relationship, Drug; Glutamic Acid; Histidine; Humans; Ionomycin; Ionophores; Ischemia; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neurons; Plasmids; Protein Binding; Protein Biosynthesis; Protein Structure, Tertiary; Rats; Sequence Analysis, DNA; Time Factors; Transcription, Genetic; Transfection

2002
Calcium-dependent cleavage of endogenous wild-type huntingtin in primary cortical neurons.
    The Journal of biological chemistry, 2002, Oct-18, Volume: 277, Issue:42

    Topics: Animals; Blotting, Western; Brain; Calcimycin; Calcium; Calpain; Cell-Free System; Cells, Cultured; Densitometry; Glutamic Acid; Huntingtin Protein; Ionophores; Nerve Tissue Proteins; Neurons; Nitro Compounds; Nuclear Proteins; Propionates; Protein Binding; Rats; Rats, Sprague-Dawley; Time Factors

2002
Cleavage of the cyclin-dependent kinase 5 activator p35 to p25 does not induce tau hyperphosphorylation.
    Biochemical and biophysical research communications, 2002, Nov-15, Volume: 298, Issue:5

    Topics: Animals; Calcimycin; Calpain; Cells, Cultured; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Dipeptides; Enzyme Activation; Enzyme Inhibitors; Glutamic Acid; Ionomycin; Ionophores; N-Methylaspartate; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurofibrillary Tangles; Neurons; Phosphorylation; Rats; tau Proteins

2002
A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I.
    The Journal of clinical investigation, 2003, Volume: 111, Issue:1

    Topics: Amino Acid Sequence; Animals; Apolipoprotein A-I; Arteriosclerosis; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Biological Transport; Calpain; Cell Line; Cell Membrane; Cells, Cultured; Chickens; Cholesterol; Cross-Linking Reagents; Dipeptides; DNA; Dose-Response Relationship, Drug; Endopeptidases; Glutamic Acid; Hepatocytes; Humans; Ligands; Lipid Metabolism; Macrophages; Mice; Molecular Sequence Data; Phospholipids; Plasmids; Proline; Serine; Threonine; Time Factors; Transfection; Up-Regulation

2003
Glutamate substitutions at a PKA consensus site are consistent with inactivation of calpain by phosphorylation.
    FEBS letters, 2003, May-08, Volume: 542, Issue:1-3

    Topics: Amino Acid Substitution; Animals; Calcium; Calpain; Consensus Sequence; Cyclic AMP-Dependent Protein Kinases; Enzyme Stability; Glutamic Acid; Mutation; Phosphorylation; Rats; Serine; Threonine

2003
Calpain facilitates the neuron death induced by 3-nitropropionic acid and contributes to the necrotic morphology.
    Journal of neuropathology and experimental neurology, 2003, Volume: 62, Issue:6

    Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Calpain; Caspases; Cell Death; Cell Survival; Cells, Cultured; Cysteine Proteinase Inhibitors; Dizocilpine Maleate; Drug Synergism; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Immunoblotting; Immunohistochemistry; Necrosis; Neurons; Neurotoxins; Nitro Compounds; Oligopeptides; Propionates; Rats; Spectrin; Time Factors

2003
Critical role of calpain-mediated cleavage of calcineurin in excitotoxic neurodegeneration.
    The Journal of biological chemistry, 2004, Feb-06, Volume: 279, Issue:6

    Topics: Amino Acid Sequence; Animals; Binding Sites; Calcineurin; Calpain; Cells, Cultured; Glutamic Acid; Hippocampus; Kainic Acid; Male; Mice; Models, Neurological; Molecular Sequence Data; Nerve Degeneration; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2004
Selective activation induced cleavage of the NR2B subunit by calpain.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Dec-10, Volume: 23, Issue:36

    Topics: Animals; Brain Ischemia; Calpain; Cell Line; Cells, Cultured; Enzyme Activation; Glutamic Acid; Hippocampus; Humans; Male; Neurons; Protein Subunits; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate

2003
Glutamate activates NF-kappaB through calpain in neurons.
    The European journal of neuroscience, 2003, Volume: 18, Issue:12

    Topics: Active Transport, Cell Nucleus; Animals; Animals, Newborn; Calpain; Cell Death; Cell Differentiation; Cell Survival; Cells, Cultured; Cerebellar Cortex; Dipeptides; Down-Regulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; I-kappa B Proteins; Immunohistochemistry; Memory; Mice; Nervous System; Neurons; NF-kappa B; NF-KappaB Inhibitor alpha; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Signal Transduction

2003
17beta-estradiol attenuates glutamate-induced apoptosis and preserves electrophysiologic function in primary cortical neurons.
    Journal of neuroscience research, 2004, Jun-01, Volume: 76, Issue:5

    Topics: Animals; Animals, Newborn; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Calpain; Caspase 3; Caspases; Cell Count; Cells, Cultured; Cerebral Cortex; Drug Interactions; Electrophysiology; Estradiol; Glutamic Acid; Membrane Potentials; Neurons; Oligonucleotides, Antisense; Patch-Clamp Techniques; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Sodium Channels

2004
The E46K mutation in alpha-synuclein increases amyloid fibril formation.
    The Journal of biological chemistry, 2005, Mar-04, Volume: 280, Issue:9

    Topics: Alanine; alpha-Synuclein; Amino Acid Sequence; Amyloid; Blotting, Western; Calpain; Chromatography, Gel; Circular Dichroism; DNA, Complementary; Glutamic Acid; Humans; Kinetics; Lysine; Microscopy, Electron; Molecular Sequence Data; Mutation; Nerve Tissue Proteins; Protein Conformation; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Synucleins; Time Factors

2005
Minocycline in phenotypic models of Huntington's disease.
    Neurobiology of disease, 2005, Volume: 18, Issue:1

    Topics: Animals; Calpain; Caspases; Cell Death; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalitis; Glutamic Acid; Huntingtin Protein; Huntington Disease; Male; Minocycline; Nerve Degeneration; Nerve Tissue Proteins; Neuroprotective Agents; Nitro Compounds; Nuclear Proteins; Phenotype; Propionates; Quinolinic Acid; Rats; Rats, Inbred Lew; Rats, Wistar; Staurosporine

2005
Regulation of N-methyl-D-aspartate receptors by calpain in cortical neurons.
    The Journal of biological chemistry, 2005, Jun-03, Volume: 280, Issue:22

    Topics: Animals; Blotting, Western; Calcium; Calpain; Down-Regulation; Dynamins; Endocytosis; Enzyme Inhibitors; Glutamic Acid; Immunoblotting; Ischemia; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Peptides; Rats; Receptors, N-Methyl-D-Aspartate; Time Factors

2005
Calpain activation in apoptosis of ventral spinal cord 4.1 (VSC4.1) motoneurons exposed to glutamate: calpain inhibition provides functional neuroprotection.
    Journal of neuroscience research, 2005, Aug-15, Volume: 81, Issue:4

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Calcium; Calpain; Caspase 3; Caspases; Cell Fusion; Cysteine Proteinase Inhibitors; Cytochromes c; Dipeptides; Glutamic Acid; Humans; Ionomycin; Ionophores; Mice; Mitochondria; Motor Neurons; Neuroblastoma; Neuroprotective Agents; Patch-Clamp Techniques; Proto-Oncogene Proteins c-bcl-2; Rats; Spectrin; Spinal Cord

2005
Negative regulation of neurotransmitter release by calpain: a possible involvement of specific SNAP-25 cleavage.
    Journal of neurochemistry, 2005, Volume: 94, Issue:3

    Topics: Age Factors; Animals; Animals, Newborn; Antibodies; Blotting, Western; Calcium; Calpain; Cells, Cultured; Cerebellum; Chromatography, High Pressure Liquid; Dipeptides; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Excitatory Amino Acid Agonists; Glutamic Acid; Glycoproteins; Ionomycin; Ionophores; Membrane Proteins; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Potassium; Rats; Rats, Wistar; Synaptosomal-Associated Protein 25; Time Factors

2005
[Suppressive effects of par-4 antisense oligodeoxynucleotide on up-regulation of intracellular calcium concentration in PC12 cell induced by glutamate and its anti-apoptosis effects].
    Zhonghua bing li xue za zhi = Chinese journal of pathology, 2005, Volume: 34, Issue:4

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Calcium; Calpain; Glutamic Acid; Oligodeoxyribonucleotides, Antisense; PC12 Cells; Rats; RNA, Messenger; Transfection; Up-Regulation

2005
Chlortetracycline and demeclocycline inhibit calpains and protect mouse neurons against glutamate toxicity and cerebral ischemia.
    The Journal of biological chemistry, 2005, Oct-07, Volume: 280, Issue:40

    Topics: Animals; Anti-Bacterial Agents; Brain Ischemia; Calcium; Calpain; Cell Culture Techniques; Chlortetracycline; Demeclocycline; Enzyme Inhibitors; Glutamic Acid; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate

2005
Traumatic mechanical injury to the hippocampus in vitro causes regional caspase-3 and calpain activation that is influenced by NMDA receptor subunit composition.
    Neurobiology of disease, 2006, Volume: 22, Issue:1

    Topics: Animals; Animals, Newborn; Apoptosis; Biomarkers; Brain Injuries; Calpain; Caspase 3; Caspases; Dentate Gyrus; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Mechanotransduction, Cellular; Necrosis; Neurons; Organ Culture Techniques; Protein Subunits; Rats; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spectrin; Synaptic Transmission; Up-Regulation

2006
Calpain-cleaved collapsin response mediator protein-3 induces neuronal death after glutamate toxicity and cerebral ischemia.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Feb-22, Volume: 26, Issue:8

    Topics: Animals; Apoptosis; Binding Sites; Brain; Brain Ischemia; Calpain; Cells, Cultured; Glutamic Acid; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neurons; Protein Binding

2006
Inhibition of calpain and caspase-3 prevented apoptosis and preserved electrophysiological properties of voltage-gated and ligand-gated ion channels in rat primary cortical neurons exposed to glutamate.
    Neuroscience, 2006, May-12, Volume: 139, Issue:2

    Topics: Amino Acid Chloromethyl Ketones; Animals; Animals, Newborn; Apoptosis; Calpain; Caspase 3; Caspase Inhibitors; Caspases; Cell Survival; Cells, Cultured; Cerebral Cortex; Chromatin; Cysteine Proteinase Inhibitors; DNA Fragmentation; Drug Interactions; Female; Glutamic Acid; Ion Channel Gating; Membrane Potentials; Neurons; Oligopeptides; Pregnancy; Rats; Rats, Sprague-Dawley

2006
Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens.
    BMC neuroscience, 2006, Jun-15, Volume: 7

    Topics: Animals; Apoptosis; Apoptosis Inducing Factor; Calpain; Caspase 3; Caspase Inhibitors; Caspases; Cell Line; Cells, Cultured; Estradiol; Estrogens; Glutamic Acid; Horses; Mice; Nerve Degeneration; Neurons; Neuroprotective Agents; Protein Transport; Rats; Signal Transduction; Up-Regulation

2006
Calpain product of WT-CRMP2 reduces the amount of surface NR2B NMDA receptor subunit.
    Journal of neurochemistry, 2006, Volume: 98, Issue:4

    Topics: Animals; Biotin; Blotting, Western; Calcium; Calpain; Cells, Cultured; Cerebral Cortex; Down-Regulation; Electrophoresis, Gel, Two-Dimensional; Excitatory Amino Acid Agonists; Glutamic Acid; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Membrane Proteins; Mice; N-Methylaspartate; Nerve Tissue Proteins; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2006
Calpain activation is required for glutamate-induced p27 down-regulation in cultured cortical neurons.
    Journal of neurochemistry, 2006, Volume: 99, Issue:3

    Topics: Animals; Astrocytes; Blotting, Western; Calpain; Caspase 3; Cell Death; Cell Nucleus; Cell Survival; Cells, Cultured; Cerebral Cortex; Cyclin-Dependent Kinase Inhibitor p27; Cytoplasm; Down-Regulation; Enzyme Activation; Glutamic Acid; Immunohistochemistry; Neurons; Proteasome Endopeptidase Complex; Rats; Signal Transduction; Ubiquitin

2006
Activity-dependent cleavage of brain glutamic acid decarboxylase 65 by calpain.
    Journal of neurochemistry, 2006, Volume: 98, Issue:5

    Topics: Animals; Blotting, Western; Brain; Calcium; Calcium-Binding Proteins; Calpain; Cells, Cultured; Chelating Agents; Dose-Response Relationship, Drug; Drug Interactions; Edetic Acid; Embryo, Mammalian; Enzyme Activation; Female; Glutamate Decarboxylase; Glutamic Acid; Immunoprecipitation; Ionomycin; Ionophores; Isoenzymes; Neurons; Pregnancy; Rats; Rats, Sprague-Dawley; Synaptosomes; Time Factors

2006
Hypoxic injury of isolated axons is independent of ionotropic glutamate receptors.
    Neurobiology of disease, 2007, Volume: 25, Issue:2

    Topics: Animals; Axons; Calcium; Calcium Signaling; Calpain; Cell Culture Techniques; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glucose; Glutamic Acid; Hypoxia; Hypoxia-Ischemia, Brain; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurotoxins; Receptors, Glutamate; Sodium; Sodium Channel Blockers; Sodium Channels; Wallerian Degeneration

2007
Sequential degradation of alphaII and betaII spectrin by calpain in glutamate or maitotoxin-stimulated cells.
    Biochemistry, 2007, Jan-16, Volume: 46, Issue:2

    Topics: Amino Acid Sequence; Animals; Binding Sites; Calmodulin; Calpain; Cattle; Cells, Cultured; Glutamic Acid; In Vitro Techniques; Marine Toxins; Molecular Sequence Data; Oxocins; Peptide Fragments; Rats; Recombinant Proteins; Spectrin

2007
Protective effects of ginsenoside Rg2 against glutamate-induced neurotoxicity in PC12 cells.
    Journal of ethnopharmacology, 2007, May-22, Volume: 111, Issue:3

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Apoptosis; Calcium; Calcium Channel Blockers; Calpain; Caspase 3; Cell Survival; Dose-Response Relationship, Drug; Gene Expression; Ginsenosides; Glutamic Acid; Lipid Peroxidation; Neuroprotective Agents; Neurotoxicity Syndromes; Nimodipine; Oxidative Stress; Panax; PC12 Cells; Peptide Fragments; Rats

2007
Glutamate receptor activation evokes calpain-mediated degradation of Sp3 and Sp4, the prominent Sp-family transcription factors in neurons.
    Journal of neurochemistry, 2007, Volume: 100, Issue:5

    Topics: Animals; Calpain; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Glutamic Acid; Ischemic Attack, Transient; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Reperfusion Injury; Sp1 Transcription Factor; Sp3 Transcription Factor; Sp4 Transcription Factor

2007
N-terminal cleavage of GSK-3 by calpain: a new form of GSK-3 regulation.
    The Journal of biological chemistry, 2007, Aug-03, Volume: 282, Issue:31

    Topics: Alzheimer Disease; Animals; Brain; Calpain; Dose-Response Relationship, Drug; Gene Expression Regulation; Glutamic Acid; Glycogen Synthase Kinase 3; Inhibitory Concentration 50; Isoenzymes; Mice; Models, Biological; Protein Structure, Tertiary; Recombinant Proteins; Signal Transduction

2007
Mild mitochondrial inhibition in vivo enhances glutamate-induced neuronal damage through calpain but not caspase activation: role of ionotropic glutamate receptors.
    Experimental neurology, 2008, Volume: 212, Issue:1

    Topics: Animals; Brain Diseases, Metabolic; Calpain; Caspase 3; Cell Death; Enzyme Activation; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Mitochondria; Mitochondrial Diseases; Nerve Degeneration; Neurotoxins; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Signal Transduction

2008
Degradation of PEP-19, a calmodulin-binding protein, by calpain is implicated in neuronal cell death induced by intracellular Ca2+ overload.
    Neuroscience, 2008, Jun-23, Volume: 154, Issue:2

    Topics: Animals; Blotting, Western; Calcium; Calmodulin; Calmodulin-Binding Proteins; Calpain; Cell Death; Cell Line; Cerebral Cortex; Cysteine Endopeptidases; Excitatory Amino Acid Agonists; Female; Gerbillinae; Glutamic Acid; Humans; Neurons; Neuroprotective Agents; Peptides; Plasmids; Pregnancy; Rats; Reverse Transcriptase Polymerase Chain Reaction; Transfection

2008
Physiological and pathological actions of calpains in glutamatergic neurons.
    Science signaling, 2008, Jun-10, Volume: 1, Issue:23

    Topics: Animals; Calpain; Cell Death; Glutamic Acid; Humans; Nerve Endings; Neuronal Plasticity; Neurons; Synapses; Synaptic Transmission

2008
Glutamate alteration of glutamic acid decarboxylase (GAD) in GABAergic neurons: the role of cysteine proteases.
    Experimental neurology, 2008, Volume: 213, Issue:1

    Topics: Animals; Brain Damage, Chronic; Calcium Signaling; Calpain; Cathepsins; Cells, Cultured; Cerebral Cortex; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Epilepsy; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Hypoxia-Ischemia, Brain; Mice; Mice, Inbred BALB C; Neurons; Neurotoxins; Receptors, N-Methyl-D-Aspartate

2008
Opposing roles for caspase and calpain death proteases in L-glutamate-induced oxidative neurotoxicity.
    Toxicology and applied pharmacology, 2008, Oct-15, Volume: 232, Issue:2

    Topics: Animals; Calpain; Caspase Inhibitors; Caspases; Cell Death; Cells, Cultured; Glutamic Acid; Mice; Neurons; Oxidative Stress; Protease Inhibitors

2008
Calpain activity contributes to the control of SNAP-25 levels in neurons.
    Molecular and cellular neurosciences, 2008, Volume: 39, Issue:3

    Topics: Animals; Brain-Derived Neurotrophic Factor; Calcium; Calpain; Cells, Cultured; Coumarins; Dipeptides; Embryo, Mammalian; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Protein Isoforms; Rats; Seizures; Synaptosomal-Associated Protein 25; Synaptosomes

2008
Rational basis for the development of coenzyme Q10 as a neurotherapeutic agent for retinal protection.
    Progress in brain research, 2008, Volume: 173

    Topics: Animals; Calpain; Cell Death; Glaucoma; Glutamic Acid; Humans; Intraocular Pressure; Neuroprotective Agents; Oxidative Stress; Rats; Reperfusion Injury; Retina; Retinal Ganglion Cells; Ubiquinone

2008
Protective function of taurine in glutamate-induced apoptosis in cultured neurons.
    Journal of neuroscience research, 2009, Volume: 87, Issue:5

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Calcium; Calpain; Caspase 9; Cell Survival; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Gene Expression Regulation; Glutamic Acid; L-Lactate Dehydrogenase; Neurons; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Taurine

2009
Reduced early hypoxic/ischemic brain damage is associated with increased GLT-1 levels in mice expressing mutant (P301L) human tau.
    Brain research, 2009, Jan-09, Volume: 1247

    Topics: Amino Acid Sequence; Animals; Apoptosis; Brain Infarction; Calpain; Caspase 3; Cytoprotection; Excitatory Amino Acid Transporter 2; Glutamic Acid; Humans; Hypoxia-Ischemia, Brain; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Degeneration; Organ Culture Techniques; tau Proteins; Up-Regulation

2009
Impaired calcium homeostasis in aged hippocampal neurons.
    Neuroscience letters, 2009, Feb-20, Volume: 451, Issue:2

    Topics: Aging; Animals; Calcium; Calcium Signaling; Calpain; Cells, Cultured; Cellular Senescence; Glutamic Acid; Hippocampus; Hydrogen Peroxide; Nerve Degeneration; Neurons; Neurotoxins; Organic Chemicals; Oxidants; Oxidative Stress; Rats; Rats, Sprague-Dawley

2009
Molecular mechanisms of neuroprotection by two natural antioxidant polyphenols.
    Cell calcium, 2009, Volume: 45, Issue:4

    Topics: Animals; Antioxidants; Apoptosis Regulatory Proteins; Calpain; Caspases; Cell Death; Cell Nucleus; Cerebral Cortex; Cytoprotection; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glutamic Acid; Membrane Potential, Mitochondrial; Neurons; Neuroprotective Agents; Neurotoxins; NF-kappa B; Phenols; Polyphenols; Protein Transport; Proto-Oncogene Proteins c-akt; Rats; Reactive Oxygen Species; Xanthones

2009
Mechanism of neuroprotective function of taurine.
    Advances in experimental medicine and biology, 2009, Volume: 643

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Calcium Channels; Calcium-Binding Proteins; Calpain; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Glutamic Acid; Ion Channel Gating; Neurons; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Rats; Receptors, N-Methyl-D-Aspartate; Taurine

2009
Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegeneration.
    The Journal of biological chemistry, 2009, May-01, Volume: 284, Issue:18

    Topics: Adaptor Protein Complex alpha Subunits; Adaptor Protein Complex beta Subunits; Adaptor Proteins, Vesicular Transport; Alzheimer Disease; Animals; Brain; Brain Ischemia; Calcium; Calpain; Cell Line; Cell Membrane; Clathrin; Endocytosis; Female; Glutamic Acid; Humans; Hydrolysis; Male; Membrane Lipids; Monomeric Clathrin Assembly Proteins; Neurons; Rats; Rats, Sprague-Dawley; Rats, Wistar

2009
Estrogen attenuates glutamate-induced cell death by inhibiting Ca2+ influx through L-type voltage-gated Ca2+ channels.
    Brain research, 2009, Jun-18, Volume: 1276

    Topics: Animals; Apoptosis; Calcium; Calcium Channel Agonists; Calcium Channels, L-Type; Calpain; Caspase 3; Cell Line; Cell Physiological Phenomena; Electric Capacitance; Estradiol; Estrogens; Glutamic Acid; Intracellular Space; Membrane Potentials; Mice; Neurons; Neuroprotective Agents; Pyrroles; Rats

2009
Real-time visualization of cytoplasmic calpain activation and calcium deregulation in acute glutamate excitotoxicity.
    Journal of neurochemistry, 2009, Volume: 110, Issue:3

    Topics: Animals; Calcium; Calpain; Cell Death; Cells, Cultured; Cerebral Cortex; Cytoplasm; Fluorescence Resonance Energy Transfer; Glutamic Acid; Rats; Time Factors

2009
Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEP.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Jul-22, Volume: 29, Issue:29

    Topics: Alternative Splicing; Animals; Brain; Calpain; Cell Death; Cells, Cultured; Cyclin-Dependent Kinase 5; Endocytosis; Glutamic Acid; In Vitro Techniques; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons; p38 Mitogen-Activated Protein Kinases; Protein Tyrosine Phosphatases, Non-Receptor; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses

2009
Alteration of the nuclear pore complex in Ca(2+)-mediated cell death.
    Cell death and differentiation, 2010, Volume: 17, Issue:1

    Topics: Animals; Apoptosis; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Calcium; Calpain; Cells, Cultured; Glutamic Acid; Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+); HeLa Cells; Humans; Nuclear Pore; Nuclear Pore Complex Proteins; Rats; Receptors, Nicotinic; Signal Transduction

2010
Downregulation of Kv4.2 channels mediated by NR2B-containing NMDA receptors in cultured hippocampal neurons.
    Neuroscience, 2010, Jan-20, Volume: 165, Issue:2

    Topics: Animals; Calcium; Calpain; Cells, Cultured; Dendrites; Down-Regulation; Glutamic Acid; Glycoproteins; Hippocampus; Membrane Potentials; Neurons; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Shal Potassium Channels; Synapses

2010
Calpain activation and Na+/Ca2+ exchanger degradation occur downstream of calcium deregulation in hippocampal neurons exposed to excitotoxic glutamate.
    Journal of neuroscience research, 2010, May-01, Volume: 88, Issue:6

    Topics: Animals; Calcium; Calpain; Cell Death; Cells, Cultured; Cysteine Proteinase Inhibitors; Dipeptides; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Membrane Potential, Mitochondrial; Mitochondria; Neurons; Neurotoxins; Rats; Sodium-Calcium Exchanger; Time Factors

2010
Cdk5 is a major regulator of p38 cascade: relevance to neurotoxicity in Alzheimer's disease.
    Journal of neurochemistry, 2010, Volume: 113, Issue:5

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blotting, Western; Calpain; Coloring Agents; Cyclin-Dependent Kinase 5; Glutamic Acid; Humans; Immunohistochemistry; MAP Kinase Kinase 6; Mice; Mice, Transgenic; Neurons; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Tetrazolium Salts; Thiazoles

2010
Role of the NR2A/2B subunits of the N-methyl-D-aspartate receptor in glutamate-induced glutamic acid decarboxylase alteration in cortical GABAergic neurons in vitro.
    Neuroscience, 2010, Dec-29, Volume: 171, Issue:4

    Topics: Analysis of Variance; Animals; Bicuculline; Calpain; Cell Survival; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Agents; GABA Agents; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamate Decarboxylase; Glutamic Acid; Glycine Agents; Membrane Potentials; Mice; Mice, Inbred BALB C; Neurons; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Strychnine

2010
Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment.
    Neurobiology of aging, 2011, Volume: 32, Issue:1

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; Calmodulin-Binding Proteins; Calpain; Cell Count; Cerebral Cortex; Cricetinae; Cricetulus; Embryo, Mammalian; Enzyme Inhibitors; Glutamic Acid; Green Fluorescent Proteins; Humans; In Situ Nick-End Labeling; Molecular Weight; Mutation; Neurons; Peptide Fragments; Peptides; Phosphorylation; Rats; tau Proteins; Thapsigargin; Transfection

2011
Proteolysis of calcineurin is increased in human hippocampus during mild cognitive impairment and is stimulated by oligomeric Abeta in primary cell culture.
    Aging cell, 2011, Volume: 10, Issue:1

    Topics: Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcineurin; Calcineurin Inhibitors; Calcium; Calpain; Case-Control Studies; Cell Culture Techniques; Cell Fractionation; Cognition Disorders; Disease Progression; Enzyme Activation; Enzyme Inhibitors; Female; Glutamic Acid; Hippocampus; Humans; Male; Peptide Fragments; Rats; Receptors, N-Methyl-D-Aspartate; Retrospective Studies; Signal Transduction

2011
A precise temporal dissection of monosodium glutamate-induced apoptotic events in newborn rat retina in vivo.
    Neurochemical research, 2011, Volume: 36, Issue:8

    Topics: Animals; Animals, Newborn; Apoptosis; Calpain; Caspases; Glutamic Acid; Isoenzymes; Rats; Rats, Wistar; Retina; Retinal Neurons; Sodium Glutamate; Time Factors

2011
Neuroprotective effects of flavonoids on hypoxia-, glutamate-, and oxidative stress-induced retinal ganglion cell death.
    Molecular vision, 2011, Volume: 17

    Topics: Animals; Antioxidants; Apoptosis; Calpain; Caspase 3; Caspase Inhibitors; Cell Culture Techniques; Cell Survival; Dose-Response Relationship, Drug; Flavonoids; Glutamic Acid; Hypoxia; Neuroprotective Agents; Oxidative Stress; Phenols; Quercetin; Rats; Rats, Wistar; Reactive Oxygen Species; Retinal Ganglion Cells; Rutin; Structure-Activity Relationship

2011
Cleavage of the vesicular glutamate transporters under excitotoxic conditions.
    Neurobiology of disease, 2011, Volume: 44, Issue:3

    Topics: Analysis of Variance; Animals; Apoptosis; Calpain; Caspase 3; Cells, Cultured; Embryo, Mammalian; Excitatory Amino Acid Agonists; Glucose; Glutamic Acid; Hippocampus; Hypoxia; Infarction, Middle Cerebral Artery; Neurons; Rats; Rats, Wistar; Synaptic Vesicles; Transfection; Vesicular Glutamate Transport Protein 1; Vesicular Glutamate Transport Protein 2

2011
Activation of NOX2 by the stimulation of ionotropic and metabotropic glutamate receptors contributes to glutamate neurotoxicity in vivo through the production of reactive oxygen species and calpain activation.
    Journal of neuropathology and experimental neurology, 2011, Volume: 70, Issue:11

    Topics: Animals; Calcium-Binding Proteins; Calpain; Corpus Striatum; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Agents; Fluoresceins; Gene Expression Regulation; Glutamic Acid; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins; Microglia; NADPH Oxidase 2; NADPH Oxidases; Neurons; Neurotoxicity Syndromes; Organic Chemicals; Phosphopyruvate Hydratase; Reactive Oxygen Species; Receptors, Immunologic; Receptors, Ionotropic Glutamate; Receptors, Metabotropic Glutamate; Time Factors

2011
Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease.
    Nature, 2011, Nov-23, Volume: 480, Issue:7378

    Topics: Ataxin-3; Calcium; Calpain; Cells, Cultured; Excitatory Amino Acids; Glutamic Acid; Humans; Machado-Joseph Disease; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Repressor Proteins

2011
Excitotoxicity downregulates TrkB.FL signaling and upregulates the neuroprotective truncated TrkB receptors in cultured hippocampal and striatal neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012, Mar-28, Volume: 32, Issue:13

    Topics: Animals; Anisomycin; Brain-Derived Neurotrophic Factor; Calpain; Cell Death; Corpus Striatum; Embryo, Mammalian; Gene Expression Regulation; Glutamic Acid; Hippocampus; Isoenzymes; Kainic Acid; Neurons; Neuroprotective Agents; Primary Cell Culture; Rats; Rats, Wistar; Receptor, trkB; rhoA GTP-Binding Protein; Signal Transduction

2012
Evidence supporting the role of calpain in the α-processing of amyloid-β precursor protein.
    Biochemical and biophysical research communications, 2012, Apr-13, Volume: 420, Issue:3

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Biotinylation; Calpain; Cell Membrane; Genetic Vectors; Glutamic Acid; HEK293 Cells; Humans; Nicotine; Phorbol 12,13-Dibutyrate; Substrate Specificity

2012
ER stress, mitochondrial dysfunction and calpain/JNK activation are involved in oligodendrocyte precursor cell death by unconjugated bilirubin.
    Neuromolecular medicine, 2012, Volume: 14, Issue:4

    Topics: Amino Acid Chloromethyl Ketones; Animals; Animals, Newborn; Apoptosis; Bilirubin; Calpain; Caspases; Cells, Cultured; Cerebral Cortex; Cytokines; Endoplasmic Reticulum Stress; Enzyme Activation; Glutamic Acid; JNK Mitogen-Activated Protein Kinases; Membrane Potential, Mitochondrial; Mitochondria; Neural Stem Cells; Oligodendroglia; Primary Cell Culture; Rats; Rats, Wistar; Reactive Oxygen Species; Signal Transduction

2012
N-methyl-D-aspartate receptor- and calpain-mediated proteolytic cleavage of K+-Cl- cotransporter-2 impairs spinal chloride homeostasis in neuropathic pain.
    The Journal of biological chemistry, 2012, Sep-28, Volume: 287, Issue:40

    Topics: Animals; Biological Transport; Calpain; Chlorides; Electrophysiology; Glutamic Acid; Homeostasis; K Cl- Cotransporters; Male; Neuralgia; Neuronal Plasticity; Pain; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; RNA, Small Interfering; Symporters; Synapses

2012
Involvement of calpain/p35-p25/Cdk5/NMDAR signaling pathway in glutamate-induced neurotoxicity in cultured rat retinal neurons.
    PloS one, 2012, Volume: 7, Issue:8

    Topics: Animals; Calcium Signaling; Calpain; Cells, Cultured; Cyclin-Dependent Kinase 5; Gene Expression Regulation; Glutamic Acid; Nerve Tissue Proteins; Proteolysis; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retinal Neurons; Time Factors

2012
Spatiotemporal resolution of BDNF neuroprotection against glutamate excitotoxicity in cultured hippocampal neurons.
    Neuroscience, 2013, May-01, Volume: 237

    Topics: Amino Acid Chloromethyl Ketones; Animals; Axons; Brain-Derived Neurotrophic Factor; Calpain; Cells, Cultured; Down-Regulation; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Glutamic Acid; Hippocampus; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Rats; Signal Transduction; Time Factors; TRPC Cation Channels

2013
Neuroprotective effects of Polygonum multiflorum extract against glutamate-induced oxidative toxicity in HT22 hippocampal cells.
    Journal of ethnopharmacology, 2013, Oct-28, Volume: 150, Issue:1

    Topics: Animals; Apoptosis; Calpain; Cell Line; Cell Survival; Cyclic AMP Response Element-Binding Protein; Glutamic Acid; Hippocampus; Mice; Mitogen-Activated Protein Kinases; Neuroprotective Agents; Oxidative Stress; Plant Extracts; Plant Roots; Polygonum

2013
Ammonia mediates methamphetamine-induced increases in glutamate and excitotoxicity.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2014, Volume: 39, Issue:4

    Topics: Ammonia; Animals; Aspartic Acid; Body Temperature; Brain; Calpain; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Administration Routes; Glial Fibrillary Acidic Protein; Glutamic Acid; Lactulose; Male; Methamphetamine; Molecular Weight; Rats; Rats, Sprague-Dawley; Spectrin; Time Factors

2014
Neuroprotective effects of a novel single compound 1-methoxyoctadecan-1-ol isolated from Uncaria sinensis in primary cortical neurons and a photothrombotic ischemia model.
    PloS one, 2014, Volume: 9, Issue:1

    Topics: Animals; Brain Ischemia; Calpain; Cerebral Cortex; Disease Models, Animal; Enzyme Inhibitors; Fatty Alcohols; Gene Expression Regulation; Glutamic Acid; Imidazoles; Mice; Neurons; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Photochemical Processes; Primary Cell Culture; Protein Tyrosine Phosphatases, Non-Receptor; Pyridines; Rats; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Thrombosis; Uncaria

2014
Relationships between calpains and glutamate- or kainate-induced apoptosis in Xenopus laevis tadpoles.
    Folia histochemica et cytobiologica, 2013, Volume: 51, Issue:4

    Topics: Animals; Apoptosis; Calpain; Glutamic Acid; Kainic Acid; Larva; Xenopus laevis; Xenopus Proteins

2013
High-energy compounds mobilize intracellular Ca2+ and activate calpain in cultured cells: is calpain an energy-dependent protease?
    Brain research bulletin, 2014, Volume: 102

    Topics: Acetyl Coenzyme A; Adenosine Triphosphate; Alzheimer Disease; Calcium; Calpain; Cell Line, Tumor; Chelating Agents; Cysteine Proteinase Inhibitors; Dipeptides; Egtazic Acid; Extracellular Space; Glutamic Acid; Humans; Intracellular Space; Nicotine; Nicotinic Agonists; Phosphocreatine; Phosphoenolpyruvate; Rotenone; Uncoupling Agents

2014
Dysregulation of TrkB Receptors and BDNF Function by Amyloid-β Peptide is Mediated by Calpain.
    Cerebral cortex (New York, N.Y. : 1991), 2015, Volume: 25, Issue:9

    Topics: Amyloid beta-Peptides; Animals; Brain; Brain-Derived Neurotrophic Factor; Calpain; Embryo, Mammalian; Enzyme Inhibitors; Female; Frontal Lobe; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamic Acid; Humans; Long-Term Potentiation; Male; Neurons; Pregnancy; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor, trkB; Synaptosomes

2015
MFN2 couples glutamate excitotoxicity and mitochondrial dysfunction in motor neurons.
    The Journal of biological chemistry, 2015, Jan-02, Volume: 290, Issue:1

    Topics: Animals; Calcium; Calpain; Cell Death; Embryo, Mammalian; Female; Gene Expression Regulation; Glutamic Acid; GTP Phosphohydrolases; Male; Membrane Proteins; Mice; Mice, Transgenic; Mitochondria; Mitochondrial Dynamics; Mitochondrial Proteins; Motor Neurons; Primary Cell Culture; Proteolysis; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord

2015
Chronic glutamate treatment selectively modulates AMPA RNA editing and ADAR expression and activity in primary cortical neurons.
    RNA biology, 2015, Volume: 12, Issue:1

    Topics: Adenosine Deaminase; Animals; Calcium; Calpain; Cell Line; Cell Survival; Glutamic Acid; Membrane Proteins; Neurons; Primary Cell Culture; Rats, Sprague-Dawley; Receptors, AMPA; RNA, Messenger

2015
Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons.
    Cell death & disease, 2015, Feb-12, Volume: 6

    Topics: Animals; Brain Ischemia; Calpain; Cells, Cultured; Glial Cell Line-Derived Neurotrophic Factor; Glutamic Acid; Hippocampus; Humans; Mice; Neurons; Proto-Oncogene Proteins c-ret; Rats; Signal Transduction

2015
Calpain inhibitor PD150606 attenuates glutamate induced spiral ganglion neuron apoptosis through apoptosis inducing factor pathway in vitro.
    PloS one, 2015, Volume: 10, Issue:4

    Topics: Acrylates; Amino Acid Chloromethyl Ketones; Animals; Animals, Newborn; Apoptosis; Apoptosis Inducing Factor; Calpain; Caspase Inhibitors; Caspases; Cell Nucleus; Gene Expression Regulation; Glutamic Acid; Glycoproteins; Mitochondria; Neurons; Primary Cell Culture; Protein Transport; Rats; Rats, Sprague-Dawley; Signal Transduction; Spiral Ganglion

2015
Apoptosis-inducing factor and calpain upregulation in glutamate-induced injury of rat spiral ganglion neurons.
    Molecular medicine reports, 2015, Volume: 12, Issue:2

    Topics: Animals; Apoptosis Inducing Factor; Calpain; Caspase 3; Cell Nucleus; Cells, Cultured; Evoked Potentials, Auditory, Brain Stem; Female; Glutamic Acid; Microscopy, Electron, Transmission; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Spiral Ganglion; Up-Regulation

2015
Gephyrin Cleavage in In Vitro Brain Ischemia Decreases GABAA Receptor Clustering and Contributes to Neuronal Death.
    Molecular neurobiology, 2016, Volume: 53, Issue:6

    Topics: Animals; Brain Ischemia; Calpain; Carrier Proteins; Cell Death; Cells, Cultured; Down-Regulation; Glucose; Glutamic Acid; Male; Membrane Proteins; Mice, Inbred C57BL; Neurons; Neurotoxins; Oxygen; Rats, Wistar; Receptors, GABA-A; Synapses

2016
Effect of Melatonin on Glutamate: BDNF Signaling in the Cerebral Cortex of Polychlorinated Biphenyls (PCBs)-Exposed Adult Male Rats.
    Neurochemical research, 2015, Volume: 40, Issue:9

    Topics: Animals; Brain-Derived Neurotrophic Factor; Calcium Channels, N-Type; Calpain; Cerebral Cortex; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Glutamic Acid; Male; Melatonin; Polychlorinated Biphenyls; Rats; Receptors, Glutamate; RNA, Messenger; Signal Transduction

2015
Reduction of glutamate-induced excitotoxicity in murine primary neurons involving calpain inhibition.
    Journal of the neurological sciences, 2015, Dec-15, Volume: 359, Issue:1-2

    Topics: alpha 1-Antitrypsin; Analysis of Variance; Animals; Calpain; Caspase 3; Cell Survival; Cells, Cultured; Cerebral Cortex; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acids; Glutamic Acid; Mice; Neurons; Phosphotransferases; Time Factors

2015
Effect of glutamate on lysosomal membrane permeabilization in primary cultured cortical neurons.
    Molecular medicine reports, 2016, Volume: 13, Issue:3

    Topics: Animals; Calpain; Cell Membrane Permeability; Cells, Cultured; Cerebral Cortex; Glutamic Acid; Lysosomes; Neurons; Primary Cell Culture; Rats, Sprague-Dawley; Reactive Oxygen Species

2016
Glutamate protects against Ca(2+) paradox-induced injury and inhibits calpain activity in isolated rat hearts.
    Clinical and experimental pharmacology & physiology, 2016, Volume: 43, Issue:10

    Topics: Animals; Calcium; Calpain; Cardiotonic Agents; Glutamic Acid; Heart; Male; Myocardial Reperfusion Injury; Organ Culture Techniques; Rats; Rats, Sprague-Dawley

2016
Neuropeptide Y Y2 and Y5 receptors as promising targets for neuroprotection in primary neurons exposed to oxygen-glucose deprivation and in transient focal cerebral ischemia in rats.
    Neuroscience, 2017, 03-06, Volume: 344

    Topics: Animals; Brain; Calpain; Cell Hypoxia; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Gait; Glucose; Glutamic Acid; Ischemic Attack, Transient; Male; Mice; Neurons; Neuroprotection; Neuroprotective Agents; Random Allocation; Rats, Sprague-Dawley; Receptors, Neuropeptide Y

2017
[Peptide drug cortexin inhibits brain caspase-8].
    Biomeditsinskaia khimiia, 2017, Volume: 63, Issue:1

    Topics: Animals; Brain; Brain Chemistry; Calpain; Caspase 1; Caspase 3; Caspase 8; Caspase 9; Cathepsin B; Cattle; Cell Death; Excitatory Amino Acid Antagonists; Gene Expression; Glutamic Acid; Neurons; Neuroprotective Agents; Primary Cell Culture; Protease Inhibitors; Protein Hydrolysates; Rats; Rats, Wistar

2017
Aquilariae Lignum extract attenuates glutamate-induced neuroexcitotoxicity in HT22 hippocampal cells.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 106

    Topics: Animals; Apoptosis; Calcium Signaling; Calpain; Cell Line; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Mice; Neurons; Neuroprotective Agents; Phytotherapy; Plant Extracts; Plants, Medicinal; Reactive Oxygen Species; Thymelaeaceae; Time Factors

2018
Calpain2 but not calpain1 mediated by calpastatin following glutamate-induced regulated necrosis in rat retinal neurons.
    Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, 2019, Volume: 221

    Topics: Animals; Calpain; Disease Models, Animal; Glutamic Acid; Necrosis; Rats; Rats, Sprague-Dawley; Retinal Neurons

2019
Calpain-dependent Beclin1 cleavage stimulates senescence-associated cell death in HT22 hippocampal cells under the oxidative stress conditions.
    Neuroscience letters, 2019, 05-14, Volume: 701

    Topics: Animals; Apoptosis; Beclin-1; Calpain; Caspases; Cell Line; Cell Survival; Cellular Senescence; Glutamic Acid; HeLa Cells; Hippocampus; Humans; Leupeptins; Mice; Neurons; NIH 3T3 Cells; Oxidative Stress; Reactive Oxygen Species

2019
Excitotoxic targeting of Kidins220 to the Golgi apparatus precedes calpain cleavage of Rap1-activation complexes.
    Cell death & disease, 2019, 07-11, Volume: 10, Issue:7

    Topics: Animals; Calpain; Cell Death; Cells, Cultured; Endocytosis; Endosomes; Glutamic Acid; Golgi Apparatus; Membrane Proteins; Mitogen-Activated Protein Kinase 3; Neurons; Phosphoproteins; rab5 GTP-Binding Proteins; rap1 GTP-Binding Proteins; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Signal Transduction

2019
Activity-dependent cleavage of dyskinesia-related proline-rich transmembrane protein 2 (PRRT2) by calpain in mouse primary cortical neurons.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020, Volume: 34, Issue:1

    Topics: Amino Acid Sequence; Animals; Calpain; Cells, Cultured; Cerebral Cortex; Dyskinesias; Glutamic Acid; Male; Membrane Potentials; Membrane Proteins; Mice; Nerve Tissue Proteins; Neurons; Plasmids

2020
Calpain-mediated cleavage of Fbxw7 during excitotoxicity.
    Neuroscience letters, 2020, 09-25, Volume: 736

    Topics: Animals; Calpain; Cell Death; Cerebral Cortex; Cyclin-Dependent Kinase 5; F-Box-WD Repeat-Containing Protein 7; Glutamic Acid; Infarction, Middle Cerebral Artery; Neurons; Rats

2020
Lentiviral expression of calpain-1 C2-like domain peptide prevents glutamate-induced cell death in mouse hippocampal neuronal HT22 cells.
    In vitro cellular & developmental biology. Animal, 2022, Volume: 58, Issue:4

    Topics: Animals; Apoptosis Inducing Factor; Calpain; Cell Death; Glutamic Acid; Hippocampus; Mice; Oxidative Stress; Peptides

2022
Calpain-Independent Intracellular Protease Activity Is Elevated in Excitotoxic Cortical Neurons Prior to Delayed Calcium Deregulation and Mitochondrial Dysfunction.
    Biomolecules, 2022, 07-20, Volume: 12, Issue:7

    Topics: Animals; Calcium; Calpain; Cells, Cultured; Glutamic Acid; Mitochondria; Neurons; Peptide Hydrolases; Proteolysis; Rats

2022
Role of CAST-Drp1 Pathway in Retinal Neuron-Regulated Necrosis in Experimental Glaucoma.
    Current medical science, 2023, Volume: 43, Issue:1

    Topics: Animals; Calpain; Dynamins; Glaucoma; Glutamic Acid; Necrosis; Rats; Retinal Neurons

2023
Morin post-treatment surpassed calpeptin in ameliorating 3-NP-induced cortical neurotoxicity via modulation of glutamate/calpain axis, Kidins220, and BDNF/TrkB/AKT/CREB trajectory.
    International immunopharmacology, 2023, Volume: 116

    Topics: Animals; Antioxidants; Brain-Derived Neurotrophic Factor; Calpain; Cyclic AMP Response Element-Binding Protein; Flavonoids; Glutamic Acid; Membrane Proteins; Neuroprotective Agents; Phosphoproteins; Proto-Oncogene Proteins c-akt; Rats

2023
N-Terminomic Changes in Neurons During Excitotoxicity Reveal Proteolytic Events Associated With Synaptic Dysfunctions and Potential Targets for Neuroprotection.
    Molecular & cellular proteomics : MCP, 2023, Volume: 22, Issue:5

    Topics: Animals; Calpain; Cells, Cultured; Glutamic Acid; Mice; Nervous System Diseases; Neurons; Neuroprotection; Proteolysis; Rats

2023