glutamic acid has been researched along with calpain in 113 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (2.65) | 18.7374 |
| 1990's | 9 (7.96) | 18.2507 |
| 2000's | 52 (46.02) | 29.6817 |
| 2010's | 42 (37.17) | 24.3611 |
| 2020's | 7 (6.19) | 2.80 |
| Authors | Studies |
|---|---|
| Costa, E; Favaron, M; Guidotti, A; Manev, H; Siman, R | 1 |
| Christoph, G; Siman, R | 1 |
| Mellgren, RL | 1 |
| Baudry, M; Lynch, G | 1 |
| Brorson, JR; Marcuccilli, CJ; Miller, RJ | 1 |
| Coutts, CT; Foster, J; Gyte, A; Upton, R; Widdowson, PS; Wyatt, I | 1 |
| Ferger, D; Krieglstein, J; Rami, A | 1 |
| Aman, MJ; Henkart, PA; Leonard, WJ; Nakajima, H; Noguchi, M; Sarin, A; Shores, EW | 1 |
| Adamec, E; Beermann, ML; Nixon, RA | 1 |
| Baudry, M; Bi, X; Chen, J; Dang, S; Rong, Y; Wang, Z | 1 |
| Arthur, JS; Croall, DE; Dutt, P; Elce, JS | 1 |
| Gurd, JW; Lombroso, PJ; Nguyen, TH; Paul, S; Xu, Y | 1 |
| Crossin, KL; Edelman, GM; Gally, JA; Holst, BH; Krushel, LA; Vanderklish, PW | 1 |
| d'Avella, D; Hayes, RL; Newcomb, JK; Pike, BR; Wang, KK; Zhao, X | 1 |
| Friedlander, RM; Kwon, YT; Lee, MS; Li, M; Peng, J; Tsai, LH | 1 |
| Davies, PL; Elce, JS; Hosfield, CM; Jia, Z; Moldoveanu, T | 1 |
| Flood, DG; Lin, YG; Reaume, AG; Savage, MJ; Scott, RW; Siman, R; Trusko, S | 1 |
| Hirai, H | 1 |
| Patzke, H; Tsai, LH | 1 |
| Cattaneo, E; De Micheli, A; Goffredo, D; Matteoli, M; Rigamonti, D; Tartari, M; Verderio, C; Zuccato, C | 1 |
| Kerokoski, P; Pirttilä, T; Salminen, A; Soininen, H; Suuronen, T | 1 |
| Agerholm-Larsen, B; Chen, W; Linsel-Nitschke, P; Martinez, LO; Silver, DL; Tall, AR; Wang, N | 1 |
| Elce, JS; Huynh, KK; Jia, Z; Smith, SD; Wells, A | 1 |
| Bondada, V; Geddes, JW; Pang, Z; Sengoku, T; Siman, R | 1 |
| Li, ST; Lu, YF; Matsui, H; Matsushita, M; Moriwaki, A; Oda, Y; Tomizawa, K; Wei, FY; Wu, HY | 1 |
| Chen, Z; Dong, Y; Guttmann, RP; Lynch, DR; Neumar, RW; Simpkins, KL; Sokol, S | 1 |
| Potrovita, I; Prinz, S; Schölzke, MN; Schwaninger, M; Subramaniam, S | 1 |
| Banik, NL; Li, L; Nowak, MW; Ray, SK; Sribnick, EA | 1 |
| Axelsen, PH; Englander, SW; Giasson, BI; Graves, CL; Greenbaum, EA; Lupoli, MA; Lynch, DR; Mishizen-Eberz, AJ | 1 |
| Bantubungi, K; Blum, D; Brotchi, J; Brouillet, E; Chtarto, A; Déglon, N; Galas, MC; Greco, A; Jacquard, C; Levivier, M; Minghetti, L; Pintor, A; Popoli, P; Schiffmann, SN; Tai, K; Tenenbaum, L | 1 |
| Lu, YF; Matsui, H; Matsushita, M; Tomizawa, K; Wu, HY; Yan, Z; Yuen, EY | 1 |
| Appel, SH; Banik, NL; Das, A; Del Re, AM; Ray, SK; Sribnick, EA; Wingrave, JM; Woodward, JJ | 1 |
| Ando, K; Kudo, Y; Takahashi, M | 1 |
| Chen, JQ; Chen, RH; Chi, X; Fei, L; Guo, M; Guo, XR; Huang, SM; Lu, C; Pan, XQ; Wu, SH; Zhao, F | 1 |
| Brunette, E; Hou, ST; Jiang, SX; Konishi, Y; Lertvorachon, J; Mealing, G; Preston, E; Tauskela, J; Webster, J | 1 |
| Auberson, YP; DeRidder, MN; Meaney, DF; Raghupathi, R; Siman, R; Simon, MJ | 1 |
| Desbois, A; Hou, ST; Huang, D; Jiang, SX; Kappler, J; Karchewski, L; Kelly, J; Tessier, L | 1 |
| Banik, NL; Karmakar, S; Nowak, MW; Ray, SK | 1 |
| Bhavnani, BR; Zhang, Y | 1 |
| Bretin, S; Gauchy, C; Glowinski, J; Honnorat, J; Marin, P; Maus, M; Prémont, J; Rogemond, V; Torrens, Y | 1 |
| Akashiba, H; Matsuki, N; Nishiyama, N | 1 |
| Jin, Y; Lee, YH; Lin, CH; Wei, J; Wu, H; Wu, JY | 1 |
| Goldberg, MP; Underhill, SM | 1 |
| Cianci, CD; Glantz, SB; Iyer, R; Morrow, JS; Pradhan, D; Wang, KK | 1 |
| Dluzen, DE; Jin, Y; Li, N; Liu, B | 1 |
| Barger, SW; Mao, X; Simpkins, JW; Yang, SH | 1 |
| Avila, J; Goñi-Oliver, P; Hernández, F; Lucas, JJ | 1 |
| Baker, AJ; Bell, JD; Park, E | 1 |
| Del Río, P; Massieu, L | 1 |
| Kanazawa, Y; Makino, M; Morishima, Y; Nabeshima, T; Shirasaki, Y; Yamada, K | 1 |
| Liu, J; Liu, MC; Wang, KK | 1 |
| Le Roux, PD; Monnerie, H | 1 |
| Elphick, LM; Eriksson, JE; Hawat, M; Kass, GE; Meinander, A; Mikhailov, A; Toms, NJ | 1 |
| Antonucci, F; Berghuis, P; Bonanno, G; Caleo, M; Carmignoto, G; Dobszay, MB; Grumelli, C; Harkany, T; Matteoli, M; Pozzi, D; Verderio, C | 1 |
| Bagetta, G; Cavaliere, F; Cerulli, A; Corasaniti, MT; Fazzi, E; Gliozzi, M; Morrone, LA; Nucci, C; Rombolà, L; Russo, R | 1 |
| Buddhala, C; Jin, Y; Leon, R; Prentice, H; Wei, J; Wu, H; Wu, JY | 1 |
| Baudry, M; Bi, X; Cheung, S; Galeano, J; Liao, G; Nguyen, N; Zhou, M | 1 |
| Behl, C; Hajieva, P; Kuhlmann, C; Luhmann, HJ | 1 |
| Campos-Esparza, MR; Matute, C; Sánchez-Gómez, MV | 1 |
| Jin, Y; Lee, HH; Lee, YH; Lin, CH; Prentice, H; Sha, D; Wei, J; Wu, H; Wu, JY; Yang, LL | 1 |
| Clarke, PG; Delacourte, A; Grishchuk, Y; Hirling, H; Luthi-Carter, R; Puyal, J; Rudinskiy, N; Vaslin, A | 1 |
| Banik, NL; Del Re, AM; Ray, SK; Sribnick, EA; Woodward, JJ | 1 |
| Divakaruni, AS; Gerencser, AA; Hubbard, AE; Mark, KA; Mehrabian, Z; Nicholls, DG; Polster, BM | 1 |
| Baum, ML; Bibb, JA; Goebel-Goody, SM; Hawasli, AH; Kurup, P; Lombroso, PJ; Wu, PH; Xu, J; Zhang, Y | 1 |
| Bano, D; Cabrera-Socorro, A; Dinsdale, D; Ferrando-May, E; Hengartner, MO; Lambacher, N; Maida, S; McColl, B; Nicotera, P | 1 |
| Deng, P; Lei, Z; Li, Y; Xu, ZC | 1 |
| Bolshakov, A; Brustovetsky, N; Brustovetsky, T | 1 |
| Lau, A; Tymianski, M | 1 |
| Chang, KH; de Pablo, Y; Lee, HG; Lee, HP; Shah, K; Smith, MA | 1 |
| Andriessen, TM; Jacobs, B; Vos, PE | 1 |
| Coulter, DA; Hsu, FC; Le Roux, PD; Monnerie, H | 1 |
| Garg, S; Mandelkow, E; Mandelkow, EM; Timm, T; Wang, Y | 1 |
| Baig, I; Guttmann, RP; Levine, H; Mohmmad Abdul, H; Norris, CM | 1 |
| Czotter, N; Dénes, V; Gábriel, R; Lakk, M | 1 |
| Aihara, M; Araie, M; Chen, YN; Iwashina, T; Nakayama, M; Tomita-Yokotani, K | 1 |
| Bahr, BA; Carvalho, AL; Catarino, T; Duarte, CB; Fernandez, P; Gomes, JR; Inácio, AR; Lobo, AC; Mele, M; Santos, AE; Wieloch, T | 1 |
| Estrada-Sánchez, AM; Guemez-Gamboa, A; Massieu, L; Montiel, T; Morán, J; Páramo, B | 1 |
| Breuer, P; Brüstle, O; Doerr, J; Evert, BO; Hoffmann, P; Jungverdorben, J; Kesavan, J; Klockgether, T; Koch, P; Ladewig, J; Mertens, J; Peitz, M; Poppe, D; Tüting, T; Wüllner, U | 1 |
| Almeida, RD; Costa, JT; Duarte, CB; Felizzi, F; Gomes, JR; Grãos, M; Inácio, AR; Melo, CV; Monteiro, P; Pinto, MJ; Wieloch, T | 1 |
| Chen, M; Maleski, JJ; Nguyen, HT; Sawmiller, DR; Wu, Q | 1 |
| Barateiro, A; Brites, D; Fernandes, A; Silva, SL; Vaz, AR | 1 |
| Byun, HS; Chen, H; Chen, SR; Han, HD; Li, L; Lopez-Berestein, G; Pan, HL; Sood, AK; Zhou, HY | 1 |
| Chen, J; Dong, LD; Hu, XC; Miao, Y; Wang, Z; Yang, XL | 1 |
| Bahr, BA; Baptista, MS; Duarte, CB; Frommer, WB; Gomes, JR; Melo, CV; Okumoto, S | 1 |
| Baek, JU; Choi, BT; Choi, YH; Choi, YW; Hong, JW; Jang, JY; Kim, HN; Kim, YR; Shin, HK | 1 |
| Halpin, LE; Northrop, NA; Yamamoto, BK | 1 |
| Bae, DW; Choi, BT; Choi, YW; Hong, JW; Jang, JY; Kim, HN; Kim, YR; Park, SJ; Shin, HK | 1 |
| Abrouk-Vérot, L; Bouchot, C; Brun, C; Exbrayat, JM; Moudilou, E | 1 |
| Chen, M; Nguyen, HT | 1 |
| Blum, D; Buée-Scherrer, V; Caetano, AP; Castrén, E; Diógenes, MJ; Jerónimo-Santos, A; Parreira, S; Rapaz-Lérias, S; Sebastião, AM; Valente, CA; Vaz, SH | 1 |
| Fujioka, H; Li, L; Liu, Y; Pi, Y; Siedlak, SL; Su, B; Tang, F; Wang, W; Wang, X; Zhang, F | 1 |
| Barbon, A; Bonini, D; Colombi, M; Filippini, A; Fiorentini, C; Fumagalli, F; La Via, L | 1 |
| Canzoniero, LM; Curcio, M; Duarte, CB; Duarte, EP; Inácio, AR; Salazar, IL | 1 |
| Chen, FQ; Chen, X; Chen, XD; Ding, ZJ; Lin, Y; Mi, WJ; Qiu, JH; Song, YL; Tang, XX; Wang, J; Wang, X | 1 |
| Chen, FQ; Chen, X; Chen, XD; Ding, ZJ; Mi, WJ; Qiu, JH; Song, YL; Tang, XX; Wang, J; Wang, RF; Wang, X | 1 |
| Baptista, MS; Costa, JT; de Almeida, LP; Duarte, CB; Gomes, JR; Mele, M; Nobre, RJ; Ruscher, K; Wieloch, T | 1 |
| Arunakaran, J; Bavithra, S; Krishnamoorthy, G; Selvakumar, K; Sugantha Priya, E | 1 |
| Bach, JP; Dodel, R; Dontcheva, G; Gold, M; Habib, P; Koczulla, AR; Koepke, J; Mengel, D | 1 |
| Chen, W; Leng, T; Li, Y; Lin, S; Lu, B; Qiu, P; Tang, L; Yan, G; Yan, M; Yin, W; Zheng, X; Zhu, W | 1 |
| Gu, XM; Jin, ZX; Kong, LH; Lai, D; Zhang, JY; Zhou, JJ | 1 |
| Boguszewski, PM; Domin, H; Jantas, D; Kozniewska, E; Przykaza, Ł; Śmiałowska, M | 1 |
| Guekht, AB; Gulyaeva, NV; Khaspekov, LG; Lyzhin, AA; Yakovlev, AA | 1 |
| Jeon, YJ; Kim, WY; Lee, JS; Lee, SK; Son, CG | 1 |
| Chen, D; Huang, J; Huang, Y; Ji, D; Liao, L; Liu, F; Wang, M; Wang, S; Wang, Z; Xia, X; Xiong, K; Yan, Y; Zhou, H | 1 |
| Ahmed, M; Hwang, JS; Kim, DR; Lai, TH; Nguyen, HQ; Pham, TM; Zada, S | 1 |
| Díaz-Guerra, M; Gamir-Morralla, A; Iglesias, T; López-Menéndez, C; Luján, R; Mochizuki, N; Pose-Utrilla, J; Simón-García, A | 1 |
| Hatta, D; Hori, Y; Iwata, N; Kurotaki, N; Shirotani, K | 1 |
| Kim, WK; Ko, YU; Oh, YJ; Song, HY; Yun, N; Yune, TY | 1 |
| Fukuda, T; Oikawa, T; Ozaki, T; Tomita, H; Yamashita, T | 1 |
| Arze, R; Hudson, D; Mark, KA; Polster, BM | 1 |
| Huang, JF; Liao, LS; Liu, SM; Wang, SC | 1 |
| Abdallah, DM; El-Abhar, HS; Fayez, AM; Mohamed, OE; Mohamed, RA | 1 |
| Ameen, SS; Ang, CS; Basheer, F; Bokhari, L; Cheng, HC; Ciccotosto, GD; Clarkson, AN; Dhillon, A; Draxler, DF; Dufour, A; Griem-Krey, N; Hoque, A; Hossain, MI; Kamaruddin, MA; Kleifeld, O; Leeming, MG; Lim, JP; Liu, D; Lucet, IS; Medcalf, RL; Nandurkar, H; Paradkar, PN; Roulston, CL; Sturgeon, S; Wellendorph, P; Williamson, NA; Zhu, HJ | 1 |
4 review(s) available for glutamic acid and calpain
| Article | Year |
|---|---|
Calcium-dependent proteases: an enzyme system active at cellular membranes?
Topics: Calcium; Calpain; Cell Fusion; Enzyme Activation; Glutamates; Glutamic Acid; Isoenzymes; Membrane Proteins; Memory; Protein Kinase C | 1987 |
Traumatic brain injury: can the consequences be stopped?
Topics: Animals; Axons; Biomarkers; Brain Edema; Brain Injuries; Calcium; Calpain; Diffuse Axonal Injury; Glutamic Acid; Humans; Intracranial Hypertension; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate | 2008 |
Glutamate receptors, neurotoxicity and neurodegeneration.
Topics: Animals; Antioxidants; Calcium; Calpain; Caspases; Cell Death; Free Radical Scavengers; Free Radicals; Glutamic Acid; Humans; Hypothalamus; Nerve Degeneration; Neurodegenerative Diseases; Neurotoxicity Syndromes; Nitric Oxide; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Sodium-Calcium Exchanger; Zinc | 2010 |
Clinical characteristics and pathophysiological mechanisms of focal and diffuse traumatic brain injury.
Topics: Brain Edema; Brain Injuries; Calpain; Caspases; Diffuse Axonal Injury; Excitatory Amino Acids; Glasgow Coma Scale; Glutamic Acid; Humans; Injury Severity Score; Magnetic Resonance Imaging; Mitochondria; Necrosis; Neurotransmitter Agents | 2010 |
109 other study(ies) available for glutamic acid and calpain
| Article | Year |
|---|---|
Glutamate neurotoxicity is independent of calpain I inhibition in primary cultures of cerebellar granule cells.
Topics: Animals; Animals, Newborn; Calcium; Calpain; Cell Survival; Cells, Cultured; Cerebellum; Gangliosides; Glutamates; Glutamic Acid; Granulocytes; Nervous System; Neurons; Osmolar Concentration; Spectrin | 1991 |
beta-Amyloid precursor is a PEST protein.
Topics: Amino Acid Sequence; Amyloid; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Brain Chemistry; Calpain; Glutamates; Glutamic Acid; Molecular Sequence Data; Proline; Protease Inhibitors; Protein Precursors; Rats; Serine; Threonine | 1989 |
The biochemistry of memory: a new and specific hypothesis.
Topics: Animals; Calcium; Calpain; Carrier Proteins; Cerebral Cortex; Endopeptidases; Glutamates; Glutamic Acid; Hippocampus; Humans; Learning; Leupeptins; Memory; Microfilament Proteins; Neuronal Plasticity; Rabbits; Rats; Receptors, Cell Surface; Receptors, Glutamate; Receptors, Neurotransmitter; Synapses; Synaptic Membranes; Telencephalon | 1984 |
Delayed antagonism of calpain reduces excitotoxicity in cultured neurons.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Calpain; Cell Survival; Cells, Cultured; Cerebellum; Dipeptides; Enzyme Activation; Glutamic Acid; Hippocampus; Kainic Acid; Leucine; N-Methylaspartate; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitroarginine; Rats; Receptors, N-Methyl-D-Aspartate; Spectrin; Time Factors | 1995 |
Calpain activation and not oxidative damage mediates L-2-chloropropionic acid-induced cerebellar granule cell necrosis.
Topics: Administration, Oral; Animals; Antioxidants; Ascorbic Acid; Aspartic Acid; Blotting, Western; Calpain; Cerebellum; Free Radicals; Glutamic Acid; Hydrocarbons, Chlorinated; Lipid Peroxidation; Male; Necrosis; Nervous System Diseases; Neurons; Oxidative Stress; Propionates; Rats; Spectrin | 1997 |
Blockade of calpain proteolytic activity rescues neurons from glutamate excitotoxicity.
Topics: Animals; Calpain; Cells, Cultured; Cysteine Proteinase Inhibitors; Dipeptides; Glutamic Acid; Glycoproteins; Hippocampus; Leucine; Neurons; Neuroprotective Agents; Neurotoxins; Rats | 1997 |
Functional cleavage of the common cytokine receptor gamma chain (gammac) by calpain.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Calpain; CD4-Positive T-Lymphocytes; Cells, Cultured; DNA Primers; Glutamic Acid; Humans; Interleukin-2; Ionomycin; Lymphocyte Activation; Macromolecular Substances; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutagenesis, Site-Directed; Polymerase Chain Reaction; Proline; Protein Biosynthesis; Receptor-CD3 Complex, Antigen, T-Cell; Receptors, Cytokine; Recombinant Proteins; Sequence Alignment; Serine; Signal Transduction; Substrate Specificity; T-Lymphocytes; Threonine | 1997 |
Calpain I activation in rat hippocampal neurons in culture is NMDA receptor selective and not essential for excitotoxic cell death.
Topics: Animals; Calcium; Calpain; Cell Death; Cells, Cultured; Embryo, Mammalian; Enzyme Activation; Glutamic Acid; Hippocampus; Neurons; Neurotoxins; Rats; Receptors, N-Methyl-D-Aspartate | 1998 |
Calpain-mediated regulation of NMDA receptor structure and function.
Topics: Animals; Calcium; Calpain; Cysteine Proteinase Inhibitors; Dipeptides; Enzyme Activation; Excitatory Amino Acid Agonists; Freezing; Glutamic Acid; Hippocampus; Ion Channel Gating; Kainic Acid; Neuronal Plasticity; Organ Culture Techniques; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Membranes | 1998 |
m-Calpain subunits remain associated in the presence of calcium.
Topics: Alanine; Animals; Calcium; Calpain; Caseins; Catalytic Domain; Cattle; Cysteine; Dimerization; Glutamic Acid; Kinetics; Macromolecular Substances; Mutagenesis, Site-Directed; Protein Binding; Recombinant Proteins; Serine | 1998 |
Calcium-dependent cleavage of striatal enriched tyrosine phosphatase (STEP).
Topics: Animals; Calcimycin; Calcium; Calpain; Dipeptides; Egtazic Acid; Female; Glutamic Acid; Ionophores; Isoenzymes; Kinetics; Molecular Weight; Protein Tyrosine Phosphatases; Protein Tyrosine Phosphatases, Non-Receptor; Rats; Rats, Long-Evans; Thapsigargin; Transfection | 1999 |
Marking synaptic activity in dendritic spines with a calpain substrate exhibiting fluorescence resonance energy transfer.
Topics: Amino Acid Sequence; Animals; Biomarkers; Calcium; Calpain; COS Cells; Culture Techniques; Dendrites; Energy Transfer; Fluorescence; Glutamic Acid; Green Fluorescent Proteins; Hippocampus; Intracellular Fluid; Long-Term Potentiation; Luminescent Proteins; Microscopy, Fluorescence; Molecular Sequence Data; N-Methylaspartate; Rats; Receptors, Glutamate; Recombinant Fusion Proteins; Spectrin; Spectrometry, Fluorescence; Substrate Specificity; Synaptic Transmission | 2000 |
Novel characteristics of glutamate-induced cell death in primary septohippocampal cultures: relationship to calpain and caspase-3 protease activation.
Topics: Animals; Calpain; Caspase 3; Caspases; Cell Death; Cells, Cultured; Coculture Techniques; Enzyme Activation; Fetus; Glutamic Acid; Hippocampus; Neuroglia; Neurons; Rats; Receptors, N-Methyl-D-Aspartate; Septum Pellucidum; Spectrin | 2000 |
Neurotoxicity induces cleavage of p35 to p25 by calpain.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Calcium; Calpain; Cells, Cultured; Egtazic Acid; Glutamic Acid; Hydrogen Peroxide; Ionomycin; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Nerve Tissue Proteins; Neurons; Peptide Fragments; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Recombinant Proteins | 2000 |
Calpain mutants with increased Ca2+ sensitivity and implications for the role of the C(2)-like domain.
Topics: Animals; Calcium; Calpain; Crystallography, X-Ray; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Glutamic Acid; Lysine; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Point Mutation; Protein Binding; Protein Conformation; Protein Isoforms; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Salts; Serine | 2001 |
Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability.
Topics: Alzheimer Disease; Amino Acid Substitution; Amyloid; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Apoptosis; Calpain; Caspases; Cell Survival; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Gene Targeting; Glutamic Acid; Homozygote; Membrane Proteins; Mice; Mice, Mutant Strains; Mice, Transgenic; Neurons; Peptide Fragments; Presenilin-1; Staurosporine | 2000 |
Ca2+-dependent regulation of synaptic delta2 glutamate receptor density in cultured rat Purkinje neurons.
Topics: Actins; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Calpain; Cells, Cultured; Cerebellum; Cycloleucine; Dendrites; Endocytosis; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Intracellular Fluid; Neuroprotective Agents; Purkinje Cells; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Synaptic Membranes; Synaptic Transmission | 2001 |
Calpain-mediated cleavage of the cyclin-dependent kinase-5 activator p39 to p29.
Topics: Animals; Blotting, Western; Brain; Calcium; Calpain; Carrier Proteins; COS Cells; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; DNA; Dose-Response Relationship, Drug; Glutamic Acid; Histidine; Humans; Ionomycin; Ionophores; Ischemia; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neurons; Plasmids; Protein Binding; Protein Biosynthesis; Protein Structure, Tertiary; Rats; Sequence Analysis, DNA; Time Factors; Transcription, Genetic; Transfection | 2002 |
Calcium-dependent cleavage of endogenous wild-type huntingtin in primary cortical neurons.
Topics: Animals; Blotting, Western; Brain; Calcimycin; Calcium; Calpain; Cell-Free System; Cells, Cultured; Densitometry; Glutamic Acid; Huntingtin Protein; Ionophores; Nerve Tissue Proteins; Neurons; Nitro Compounds; Nuclear Proteins; Propionates; Protein Binding; Rats; Rats, Sprague-Dawley; Time Factors | 2002 |
Cleavage of the cyclin-dependent kinase 5 activator p35 to p25 does not induce tau hyperphosphorylation.
Topics: Animals; Calcimycin; Calpain; Cells, Cultured; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Dipeptides; Enzyme Activation; Enzyme Inhibitors; Glutamic Acid; Ionomycin; Ionophores; N-Methylaspartate; Nerve Tissue Proteins; Neurodegenerative Diseases; Neurofibrillary Tangles; Neurons; Phosphorylation; Rats; tau Proteins | 2002 |
A PEST sequence in ABCA1 regulates degradation by calpain protease and stabilization of ABCA1 by apoA-I.
Topics: Amino Acid Sequence; Animals; Apolipoprotein A-I; Arteriosclerosis; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Biological Transport; Calpain; Cell Line; Cell Membrane; Cells, Cultured; Chickens; Cholesterol; Cross-Linking Reagents; Dipeptides; DNA; Dose-Response Relationship, Drug; Endopeptidases; Glutamic Acid; Hepatocytes; Humans; Ligands; Lipid Metabolism; Macrophages; Mice; Molecular Sequence Data; Phospholipids; Plasmids; Proline; Serine; Threonine; Time Factors; Transfection; Up-Regulation | 2003 |
Glutamate substitutions at a PKA consensus site are consistent with inactivation of calpain by phosphorylation.
Topics: Amino Acid Substitution; Animals; Calcium; Calpain; Consensus Sequence; Cyclic AMP-Dependent Protein Kinases; Enzyme Stability; Glutamic Acid; Mutation; Phosphorylation; Rats; Serine; Threonine | 2003 |
Calpain facilitates the neuron death induced by 3-nitropropionic acid and contributes to the necrotic morphology.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Calpain; Caspases; Cell Death; Cell Survival; Cells, Cultured; Cysteine Proteinase Inhibitors; Dizocilpine Maleate; Drug Synergism; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Immunoblotting; Immunohistochemistry; Necrosis; Neurons; Neurotoxins; Nitro Compounds; Oligopeptides; Propionates; Rats; Spectrin; Time Factors | 2003 |
Critical role of calpain-mediated cleavage of calcineurin in excitotoxic neurodegeneration.
Topics: Amino Acid Sequence; Animals; Binding Sites; Calcineurin; Calpain; Cells, Cultured; Glutamic Acid; Hippocampus; Kainic Acid; Male; Mice; Models, Neurological; Molecular Sequence Data; Nerve Degeneration; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2004 |
Selective activation induced cleavage of the NR2B subunit by calpain.
Topics: Animals; Brain Ischemia; Calpain; Cell Line; Cells, Cultured; Enzyme Activation; Glutamic Acid; Hippocampus; Humans; Male; Neurons; Protein Subunits; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate | 2003 |
Glutamate activates NF-kappaB through calpain in neurons.
Topics: Active Transport, Cell Nucleus; Animals; Animals, Newborn; Calpain; Cell Death; Cell Differentiation; Cell Survival; Cells, Cultured; Cerebellar Cortex; Dipeptides; Down-Regulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; I-kappa B Proteins; Immunohistochemistry; Memory; Mice; Nervous System; Neurons; NF-kappa B; NF-KappaB Inhibitor alpha; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2003 |
17beta-estradiol attenuates glutamate-induced apoptosis and preserves electrophysiologic function in primary cortical neurons.
Topics: Animals; Animals, Newborn; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Calpain; Caspase 3; Caspases; Cell Count; Cells, Cultured; Cerebral Cortex; Drug Interactions; Electrophysiology; Estradiol; Glutamic Acid; Membrane Potentials; Neurons; Oligonucleotides, Antisense; Patch-Clamp Techniques; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Sodium Channels | 2004 |
The E46K mutation in alpha-synuclein increases amyloid fibril formation.
Topics: Alanine; alpha-Synuclein; Amino Acid Sequence; Amyloid; Blotting, Western; Calpain; Chromatography, Gel; Circular Dichroism; DNA, Complementary; Glutamic Acid; Humans; Kinetics; Lysine; Microscopy, Electron; Molecular Sequence Data; Mutation; Nerve Tissue Proteins; Protein Conformation; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Synucleins; Time Factors | 2005 |
Minocycline in phenotypic models of Huntington's disease.
Topics: Animals; Calpain; Caspases; Cell Death; Cells, Cultured; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalitis; Glutamic Acid; Huntingtin Protein; Huntington Disease; Male; Minocycline; Nerve Degeneration; Nerve Tissue Proteins; Neuroprotective Agents; Nitro Compounds; Nuclear Proteins; Phenotype; Propionates; Quinolinic Acid; Rats; Rats, Inbred Lew; Rats, Wistar; Staurosporine | 2005 |
Regulation of N-methyl-D-aspartate receptors by calpain in cortical neurons.
Topics: Animals; Blotting, Western; Calcium; Calpain; Down-Regulation; Dynamins; Endocytosis; Enzyme Inhibitors; Glutamic Acid; Immunoblotting; Ischemia; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Peptides; Rats; Receptors, N-Methyl-D-Aspartate; Time Factors | 2005 |
Calpain activation in apoptosis of ventral spinal cord 4.1 (VSC4.1) motoneurons exposed to glutamate: calpain inhibition provides functional neuroprotection.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Calcium; Calpain; Caspase 3; Caspases; Cell Fusion; Cysteine Proteinase Inhibitors; Cytochromes c; Dipeptides; Glutamic Acid; Humans; Ionomycin; Ionophores; Mice; Mitochondria; Motor Neurons; Neuroblastoma; Neuroprotective Agents; Patch-Clamp Techniques; Proto-Oncogene Proteins c-bcl-2; Rats; Spectrin; Spinal Cord | 2005 |
Negative regulation of neurotransmitter release by calpain: a possible involvement of specific SNAP-25 cleavage.
Topics: Age Factors; Animals; Animals, Newborn; Antibodies; Blotting, Western; Calcium; Calpain; Cells, Cultured; Cerebellum; Chromatography, High Pressure Liquid; Dipeptides; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Excitatory Amino Acid Agonists; Glutamic Acid; Glycoproteins; Ionomycin; Ionophores; Membrane Proteins; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Potassium; Rats; Rats, Wistar; Synaptosomal-Associated Protein 25; Time Factors | 2005 |
[Suppressive effects of par-4 antisense oligodeoxynucleotide on up-regulation of intracellular calcium concentration in PC12 cell induced by glutamate and its anti-apoptosis effects].
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Calcium; Calpain; Glutamic Acid; Oligodeoxyribonucleotides, Antisense; PC12 Cells; Rats; RNA, Messenger; Transfection; Up-Regulation | 2005 |
Chlortetracycline and demeclocycline inhibit calpains and protect mouse neurons against glutamate toxicity and cerebral ischemia.
Topics: Animals; Anti-Bacterial Agents; Brain Ischemia; Calcium; Calpain; Cell Culture Techniques; Chlortetracycline; Demeclocycline; Enzyme Inhibitors; Glutamic Acid; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate | 2005 |
Traumatic mechanical injury to the hippocampus in vitro causes regional caspase-3 and calpain activation that is influenced by NMDA receptor subunit composition.
Topics: Animals; Animals, Newborn; Apoptosis; Biomarkers; Brain Injuries; Calpain; Caspase 3; Caspases; Dentate Gyrus; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Mechanotransduction, Cellular; Necrosis; Neurons; Organ Culture Techniques; Protein Subunits; Rats; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spectrin; Synaptic Transmission; Up-Regulation | 2006 |
Calpain-cleaved collapsin response mediator protein-3 induces neuronal death after glutamate toxicity and cerebral ischemia.
Topics: Animals; Apoptosis; Binding Sites; Brain; Brain Ischemia; Calpain; Cells, Cultured; Glutamic Acid; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neurons; Protein Binding | 2006 |
Inhibition of calpain and caspase-3 prevented apoptosis and preserved electrophysiological properties of voltage-gated and ligand-gated ion channels in rat primary cortical neurons exposed to glutamate.
Topics: Amino Acid Chloromethyl Ketones; Animals; Animals, Newborn; Apoptosis; Calpain; Caspase 3; Caspase Inhibitors; Caspases; Cell Survival; Cells, Cultured; Cerebral Cortex; Chromatin; Cysteine Proteinase Inhibitors; DNA Fragmentation; Drug Interactions; Female; Glutamic Acid; Ion Channel Gating; Membrane Potentials; Neurons; Oligopeptides; Pregnancy; Rats; Rats, Sprague-Dawley | 2006 |
Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens.
Topics: Animals; Apoptosis; Apoptosis Inducing Factor; Calpain; Caspase 3; Caspase Inhibitors; Caspases; Cell Line; Cells, Cultured; Estradiol; Estrogens; Glutamic Acid; Horses; Mice; Nerve Degeneration; Neurons; Neuroprotective Agents; Protein Transport; Rats; Signal Transduction; Up-Regulation | 2006 |
Calpain product of WT-CRMP2 reduces the amount of surface NR2B NMDA receptor subunit.
Topics: Animals; Biotin; Blotting, Western; Calcium; Calpain; Cells, Cultured; Cerebral Cortex; Down-Regulation; Electrophoresis, Gel, Two-Dimensional; Excitatory Amino Acid Agonists; Glutamic Acid; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Membrane Proteins; Mice; N-Methylaspartate; Nerve Tissue Proteins; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2006 |
Calpain activation is required for glutamate-induced p27 down-regulation in cultured cortical neurons.
Topics: Animals; Astrocytes; Blotting, Western; Calpain; Caspase 3; Cell Death; Cell Nucleus; Cell Survival; Cells, Cultured; Cerebral Cortex; Cyclin-Dependent Kinase Inhibitor p27; Cytoplasm; Down-Regulation; Enzyme Activation; Glutamic Acid; Immunohistochemistry; Neurons; Proteasome Endopeptidase Complex; Rats; Signal Transduction; Ubiquitin | 2006 |
Activity-dependent cleavage of brain glutamic acid decarboxylase 65 by calpain.
Topics: Animals; Blotting, Western; Brain; Calcium; Calcium-Binding Proteins; Calpain; Cells, Cultured; Chelating Agents; Dose-Response Relationship, Drug; Drug Interactions; Edetic Acid; Embryo, Mammalian; Enzyme Activation; Female; Glutamate Decarboxylase; Glutamic Acid; Immunoprecipitation; Ionomycin; Ionophores; Isoenzymes; Neurons; Pregnancy; Rats; Rats, Sprague-Dawley; Synaptosomes; Time Factors | 2006 |
Hypoxic injury of isolated axons is independent of ionotropic glutamate receptors.
Topics: Animals; Axons; Calcium; Calcium Signaling; Calpain; Cell Culture Techniques; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glucose; Glutamic Acid; Hypoxia; Hypoxia-Ischemia, Brain; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurotoxins; Receptors, Glutamate; Sodium; Sodium Channel Blockers; Sodium Channels; Wallerian Degeneration | 2007 |
Sequential degradation of alphaII and betaII spectrin by calpain in glutamate or maitotoxin-stimulated cells.
Topics: Amino Acid Sequence; Animals; Binding Sites; Calmodulin; Calpain; Cattle; Cells, Cultured; Glutamic Acid; In Vitro Techniques; Marine Toxins; Molecular Sequence Data; Oxocins; Peptide Fragments; Rats; Recombinant Proteins; Spectrin | 2007 |
Protective effects of ginsenoside Rg2 against glutamate-induced neurotoxicity in PC12 cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Apoptosis; Calcium; Calcium Channel Blockers; Calpain; Caspase 3; Cell Survival; Dose-Response Relationship, Drug; Gene Expression; Ginsenosides; Glutamic Acid; Lipid Peroxidation; Neuroprotective Agents; Neurotoxicity Syndromes; Nimodipine; Oxidative Stress; Panax; PC12 Cells; Peptide Fragments; Rats | 2007 |
Glutamate receptor activation evokes calpain-mediated degradation of Sp3 and Sp4, the prominent Sp-family transcription factors in neurons.
Topics: Animals; Calpain; Cells, Cultured; Cerebral Cortex; Excitatory Amino Acid Agonists; Glutamic Acid; Ischemic Attack, Transient; Neurons; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Reperfusion Injury; Sp1 Transcription Factor; Sp3 Transcription Factor; Sp4 Transcription Factor | 2007 |
N-terminal cleavage of GSK-3 by calpain: a new form of GSK-3 regulation.
Topics: Alzheimer Disease; Animals; Brain; Calpain; Dose-Response Relationship, Drug; Gene Expression Regulation; Glutamic Acid; Glycogen Synthase Kinase 3; Inhibitory Concentration 50; Isoenzymes; Mice; Models, Biological; Protein Structure, Tertiary; Recombinant Proteins; Signal Transduction | 2007 |
Mild mitochondrial inhibition in vivo enhances glutamate-induced neuronal damage through calpain but not caspase activation: role of ionotropic glutamate receptors.
Topics: Animals; Brain Diseases, Metabolic; Calpain; Caspase 3; Cell Death; Enzyme Activation; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Mitochondria; Mitochondrial Diseases; Nerve Degeneration; Neurotoxins; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2008 |
Degradation of PEP-19, a calmodulin-binding protein, by calpain is implicated in neuronal cell death induced by intracellular Ca2+ overload.
Topics: Animals; Blotting, Western; Calcium; Calmodulin; Calmodulin-Binding Proteins; Calpain; Cell Death; Cell Line; Cerebral Cortex; Cysteine Endopeptidases; Excitatory Amino Acid Agonists; Female; Gerbillinae; Glutamic Acid; Humans; Neurons; Neuroprotective Agents; Peptides; Plasmids; Pregnancy; Rats; Reverse Transcriptase Polymerase Chain Reaction; Transfection | 2008 |
Physiological and pathological actions of calpains in glutamatergic neurons.
Topics: Animals; Calpain; Cell Death; Glutamic Acid; Humans; Nerve Endings; Neuronal Plasticity; Neurons; Synapses; Synaptic Transmission | 2008 |
Glutamate alteration of glutamic acid decarboxylase (GAD) in GABAergic neurons: the role of cysteine proteases.
Topics: Animals; Brain Damage, Chronic; Calcium Signaling; Calpain; Cathepsins; Cells, Cultured; Cerebral Cortex; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Epilepsy; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamic Acid; Hypoxia-Ischemia, Brain; Mice; Mice, Inbred BALB C; Neurons; Neurotoxins; Receptors, N-Methyl-D-Aspartate | 2008 |
Opposing roles for caspase and calpain death proteases in L-glutamate-induced oxidative neurotoxicity.
Topics: Animals; Calpain; Caspase Inhibitors; Caspases; Cell Death; Cells, Cultured; Glutamic Acid; Mice; Neurons; Oxidative Stress; Protease Inhibitors | 2008 |
Calpain activity contributes to the control of SNAP-25 levels in neurons.
Topics: Animals; Brain-Derived Neurotrophic Factor; Calcium; Calpain; Cells, Cultured; Coumarins; Dipeptides; Embryo, Mammalian; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Kainic Acid; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Protein Isoforms; Rats; Seizures; Synaptosomal-Associated Protein 25; Synaptosomes | 2008 |
Rational basis for the development of coenzyme Q10 as a neurotherapeutic agent for retinal protection.
Topics: Animals; Calpain; Cell Death; Glaucoma; Glutamic Acid; Humans; Intraocular Pressure; Neuroprotective Agents; Oxidative Stress; Rats; Reperfusion Injury; Retina; Retinal Ganglion Cells; Ubiquinone | 2008 |
Protective function of taurine in glutamate-induced apoptosis in cultured neurons.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Calcium; Calpain; Caspase 9; Cell Survival; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Gene Expression Regulation; Glutamic Acid; L-Lactate Dehydrogenase; Neurons; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Taurine | 2009 |
Reduced early hypoxic/ischemic brain damage is associated with increased GLT-1 levels in mice expressing mutant (P301L) human tau.
Topics: Amino Acid Sequence; Animals; Apoptosis; Brain Infarction; Calpain; Caspase 3; Cytoprotection; Excitatory Amino Acid Transporter 2; Glutamic Acid; Humans; Hypoxia-Ischemia, Brain; In Situ Nick-End Labeling; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Degeneration; Organ Culture Techniques; tau Proteins; Up-Regulation | 2009 |
Impaired calcium homeostasis in aged hippocampal neurons.
Topics: Aging; Animals; Calcium; Calcium Signaling; Calpain; Cells, Cultured; Cellular Senescence; Glutamic Acid; Hippocampus; Hydrogen Peroxide; Nerve Degeneration; Neurons; Neurotoxins; Organic Chemicals; Oxidants; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2009 |
Molecular mechanisms of neuroprotection by two natural antioxidant polyphenols.
Topics: Animals; Antioxidants; Apoptosis Regulatory Proteins; Calpain; Caspases; Cell Death; Cell Nucleus; Cerebral Cortex; Cytoprotection; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glutamic Acid; Membrane Potential, Mitochondrial; Neurons; Neuroprotective Agents; Neurotoxins; NF-kappa B; Phenols; Polyphenols; Protein Transport; Proto-Oncogene Proteins c-akt; Rats; Reactive Oxygen Species; Xanthones | 2009 |
Mechanism of neuroprotective function of taurine.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Calcium Channels; Calcium-Binding Proteins; Calpain; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Glutamic Acid; Ion Channel Gating; Neurons; Neuroprotective Agents; Proto-Oncogene Proteins c-bcl-2; Rats; Receptors, N-Methyl-D-Aspartate; Taurine | 2009 |
Calpain hydrolysis of alpha- and beta2-adaptins decreases clathrin-dependent endocytosis and may promote neurodegeneration.
Topics: Adaptor Protein Complex alpha Subunits; Adaptor Protein Complex beta Subunits; Adaptor Proteins, Vesicular Transport; Alzheimer Disease; Animals; Brain; Brain Ischemia; Calcium; Calpain; Cell Line; Cell Membrane; Clathrin; Endocytosis; Female; Glutamic Acid; Humans; Hydrolysis; Male; Membrane Lipids; Monomeric Clathrin Assembly Proteins; Neurons; Rats; Rats, Sprague-Dawley; Rats, Wistar | 2009 |
Estrogen attenuates glutamate-induced cell death by inhibiting Ca2+ influx through L-type voltage-gated Ca2+ channels.
Topics: Animals; Apoptosis; Calcium; Calcium Channel Agonists; Calcium Channels, L-Type; Calpain; Caspase 3; Cell Line; Cell Physiological Phenomena; Electric Capacitance; Estradiol; Estrogens; Glutamic Acid; Intracellular Space; Membrane Potentials; Mice; Neurons; Neuroprotective Agents; Pyrroles; Rats | 2009 |
Real-time visualization of cytoplasmic calpain activation and calcium deregulation in acute glutamate excitotoxicity.
Topics: Animals; Calcium; Calpain; Cell Death; Cells, Cultured; Cerebral Cortex; Cytoplasm; Fluorescence Resonance Energy Transfer; Glutamic Acid; Rats; Time Factors | 2009 |
Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEP.
Topics: Alternative Splicing; Animals; Brain; Calpain; Cell Death; Cells, Cultured; Cyclin-Dependent Kinase 5; Endocytosis; Glutamic Acid; In Vitro Techniques; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons; p38 Mitogen-Activated Protein Kinases; Protein Tyrosine Phosphatases, Non-Receptor; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses | 2009 |
Alteration of the nuclear pore complex in Ca(2+)-mediated cell death.
Topics: Animals; Apoptosis; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Calcium; Calpain; Cells, Cultured; Glutamic Acid; Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+); HeLa Cells; Humans; Nuclear Pore; Nuclear Pore Complex Proteins; Rats; Receptors, Nicotinic; Signal Transduction | 2010 |
Downregulation of Kv4.2 channels mediated by NR2B-containing NMDA receptors in cultured hippocampal neurons.
Topics: Animals; Calcium; Calpain; Cells, Cultured; Dendrites; Down-Regulation; Glutamic Acid; Glycoproteins; Hippocampus; Membrane Potentials; Neurons; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Shal Potassium Channels; Synapses | 2010 |
Calpain activation and Na+/Ca2+ exchanger degradation occur downstream of calcium deregulation in hippocampal neurons exposed to excitotoxic glutamate.
Topics: Animals; Calcium; Calpain; Cell Death; Cells, Cultured; Cysteine Proteinase Inhibitors; Dipeptides; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Membrane Potential, Mitochondrial; Mitochondria; Neurons; Neurotoxins; Rats; Sodium-Calcium Exchanger; Time Factors | 2010 |
Cdk5 is a major regulator of p38 cascade: relevance to neurotoxicity in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blotting, Western; Calpain; Coloring Agents; Cyclin-Dependent Kinase 5; Glutamic Acid; Humans; Immunohistochemistry; MAP Kinase Kinase 6; Mice; Mice, Transgenic; Neurons; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Tetrazolium Salts; Thiazoles | 2010 |
Role of the NR2A/2B subunits of the N-methyl-D-aspartate receptor in glutamate-induced glutamic acid decarboxylase alteration in cortical GABAergic neurons in vitro.
Topics: Analysis of Variance; Animals; Bicuculline; Calpain; Cell Survival; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Agents; GABA Agents; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamate Decarboxylase; Glutamic Acid; Glycine Agents; Membrane Potentials; Mice; Mice, Inbred BALB C; Neurons; Patch-Clamp Techniques; Receptors, N-Methyl-D-Aspartate; Strychnine | 2010 |
Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; Calmodulin-Binding Proteins; Calpain; Cell Count; Cerebral Cortex; Cricetinae; Cricetulus; Embryo, Mammalian; Enzyme Inhibitors; Glutamic Acid; Green Fluorescent Proteins; Humans; In Situ Nick-End Labeling; Molecular Weight; Mutation; Neurons; Peptide Fragments; Peptides; Phosphorylation; Rats; tau Proteins; Thapsigargin; Transfection | 2011 |
Proteolysis of calcineurin is increased in human hippocampus during mild cognitive impairment and is stimulated by oligomeric Abeta in primary cell culture.
Topics: Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcineurin; Calcineurin Inhibitors; Calcium; Calpain; Case-Control Studies; Cell Culture Techniques; Cell Fractionation; Cognition Disorders; Disease Progression; Enzyme Activation; Enzyme Inhibitors; Female; Glutamic Acid; Hippocampus; Humans; Male; Peptide Fragments; Rats; Receptors, N-Methyl-D-Aspartate; Retrospective Studies; Signal Transduction | 2011 |
A precise temporal dissection of monosodium glutamate-induced apoptotic events in newborn rat retina in vivo.
Topics: Animals; Animals, Newborn; Apoptosis; Calpain; Caspases; Glutamic Acid; Isoenzymes; Rats; Rats, Wistar; Retina; Retinal Neurons; Sodium Glutamate; Time Factors | 2011 |
Neuroprotective effects of flavonoids on hypoxia-, glutamate-, and oxidative stress-induced retinal ganglion cell death.
Topics: Animals; Antioxidants; Apoptosis; Calpain; Caspase 3; Caspase Inhibitors; Cell Culture Techniques; Cell Survival; Dose-Response Relationship, Drug; Flavonoids; Glutamic Acid; Hypoxia; Neuroprotective Agents; Oxidative Stress; Phenols; Quercetin; Rats; Rats, Wistar; Reactive Oxygen Species; Retinal Ganglion Cells; Rutin; Structure-Activity Relationship | 2011 |
Cleavage of the vesicular glutamate transporters under excitotoxic conditions.
Topics: Analysis of Variance; Animals; Apoptosis; Calpain; Caspase 3; Cells, Cultured; Embryo, Mammalian; Excitatory Amino Acid Agonists; Glucose; Glutamic Acid; Hippocampus; Hypoxia; Infarction, Middle Cerebral Artery; Neurons; Rats; Rats, Wistar; Synaptic Vesicles; Transfection; Vesicular Glutamate Transport Protein 1; Vesicular Glutamate Transport Protein 2 | 2011 |
Activation of NOX2 by the stimulation of ionotropic and metabotropic glutamate receptors contributes to glutamate neurotoxicity in vivo through the production of reactive oxygen species and calpain activation.
Topics: Animals; Calcium-Binding Proteins; Calpain; Corpus Striatum; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Agents; Fluoresceins; Gene Expression Regulation; Glutamic Acid; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Microfilament Proteins; Microglia; NADPH Oxidase 2; NADPH Oxidases; Neurons; Neurotoxicity Syndromes; Organic Chemicals; Phosphopyruvate Hydratase; Reactive Oxygen Species; Receptors, Immunologic; Receptors, Ionotropic Glutamate; Receptors, Metabotropic Glutamate; Time Factors | 2011 |
Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease.
Topics: Ataxin-3; Calcium; Calpain; Cells, Cultured; Excitatory Amino Acids; Glutamic Acid; Humans; Machado-Joseph Disease; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Repressor Proteins | 2011 |
Excitotoxicity downregulates TrkB.FL signaling and upregulates the neuroprotective truncated TrkB receptors in cultured hippocampal and striatal neurons.
Topics: Animals; Anisomycin; Brain-Derived Neurotrophic Factor; Calpain; Cell Death; Corpus Striatum; Embryo, Mammalian; Gene Expression Regulation; Glutamic Acid; Hippocampus; Isoenzymes; Kainic Acid; Neurons; Neuroprotective Agents; Primary Cell Culture; Rats; Rats, Wistar; Receptor, trkB; rhoA GTP-Binding Protein; Signal Transduction | 2012 |
Evidence supporting the role of calpain in the α-processing of amyloid-β precursor protein.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Biotinylation; Calpain; Cell Membrane; Genetic Vectors; Glutamic Acid; HEK293 Cells; Humans; Nicotine; Phorbol 12,13-Dibutyrate; Substrate Specificity | 2012 |
ER stress, mitochondrial dysfunction and calpain/JNK activation are involved in oligodendrocyte precursor cell death by unconjugated bilirubin.
Topics: Amino Acid Chloromethyl Ketones; Animals; Animals, Newborn; Apoptosis; Bilirubin; Calpain; Caspases; Cells, Cultured; Cerebral Cortex; Cytokines; Endoplasmic Reticulum Stress; Enzyme Activation; Glutamic Acid; JNK Mitogen-Activated Protein Kinases; Membrane Potential, Mitochondrial; Mitochondria; Neural Stem Cells; Oligodendroglia; Primary Cell Culture; Rats; Rats, Wistar; Reactive Oxygen Species; Signal Transduction | 2012 |
N-methyl-D-aspartate receptor- and calpain-mediated proteolytic cleavage of K+-Cl- cotransporter-2 impairs spinal chloride homeostasis in neuropathic pain.
Topics: Animals; Biological Transport; Calpain; Chlorides; Electrophysiology; Glutamic Acid; Homeostasis; K Cl- Cotransporters; Male; Neuralgia; Neuronal Plasticity; Pain; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; RNA, Small Interfering; Symporters; Synapses | 2012 |
Involvement of calpain/p35-p25/Cdk5/NMDAR signaling pathway in glutamate-induced neurotoxicity in cultured rat retinal neurons.
Topics: Animals; Calcium Signaling; Calpain; Cells, Cultured; Cyclin-Dependent Kinase 5; Gene Expression Regulation; Glutamic Acid; Nerve Tissue Proteins; Proteolysis; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Retinal Neurons; Time Factors | 2012 |
Spatiotemporal resolution of BDNF neuroprotection against glutamate excitotoxicity in cultured hippocampal neurons.
Topics: Amino Acid Chloromethyl Ketones; Animals; Axons; Brain-Derived Neurotrophic Factor; Calpain; Cells, Cultured; Down-Regulation; Drug Interactions; Embryo, Mammalian; Enzyme Inhibitors; Glutamic Acid; Hippocampus; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Rats; Signal Transduction; Time Factors; TRPC Cation Channels | 2013 |
Neuroprotective effects of Polygonum multiflorum extract against glutamate-induced oxidative toxicity in HT22 hippocampal cells.
Topics: Animals; Apoptosis; Calpain; Cell Line; Cell Survival; Cyclic AMP Response Element-Binding Protein; Glutamic Acid; Hippocampus; Mice; Mitogen-Activated Protein Kinases; Neuroprotective Agents; Oxidative Stress; Plant Extracts; Plant Roots; Polygonum | 2013 |
Ammonia mediates methamphetamine-induced increases in glutamate and excitotoxicity.
Topics: Ammonia; Animals; Aspartic Acid; Body Temperature; Brain; Calpain; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Administration Routes; Glial Fibrillary Acidic Protein; Glutamic Acid; Lactulose; Male; Methamphetamine; Molecular Weight; Rats; Rats, Sprague-Dawley; Spectrin; Time Factors | 2014 |
Neuroprotective effects of a novel single compound 1-methoxyoctadecan-1-ol isolated from Uncaria sinensis in primary cortical neurons and a photothrombotic ischemia model.
Topics: Animals; Brain Ischemia; Calpain; Cerebral Cortex; Disease Models, Animal; Enzyme Inhibitors; Fatty Alcohols; Gene Expression Regulation; Glutamic Acid; Imidazoles; Mice; Neurons; Neuroprotective Agents; p38 Mitogen-Activated Protein Kinases; Photochemical Processes; Primary Cell Culture; Protein Tyrosine Phosphatases, Non-Receptor; Pyridines; Rats; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Thrombosis; Uncaria | 2014 |
Relationships between calpains and glutamate- or kainate-induced apoptosis in Xenopus laevis tadpoles.
Topics: Animals; Apoptosis; Calpain; Glutamic Acid; Kainic Acid; Larva; Xenopus laevis; Xenopus Proteins | 2013 |
High-energy compounds mobilize intracellular Ca2+ and activate calpain in cultured cells: is calpain an energy-dependent protease?
Topics: Acetyl Coenzyme A; Adenosine Triphosphate; Alzheimer Disease; Calcium; Calpain; Cell Line, Tumor; Chelating Agents; Cysteine Proteinase Inhibitors; Dipeptides; Egtazic Acid; Extracellular Space; Glutamic Acid; Humans; Intracellular Space; Nicotine; Nicotinic Agonists; Phosphocreatine; Phosphoenolpyruvate; Rotenone; Uncoupling Agents | 2014 |
Dysregulation of TrkB Receptors and BDNF Function by Amyloid-β Peptide is Mediated by Calpain.
Topics: Amyloid beta-Peptides; Animals; Brain; Brain-Derived Neurotrophic Factor; Calpain; Embryo, Mammalian; Enzyme Inhibitors; Female; Frontal Lobe; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamic Acid; Humans; Long-Term Potentiation; Male; Neurons; Pregnancy; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor, trkB; Synaptosomes | 2015 |
MFN2 couples glutamate excitotoxicity and mitochondrial dysfunction in motor neurons.
Topics: Animals; Calcium; Calpain; Cell Death; Embryo, Mammalian; Female; Gene Expression Regulation; Glutamic Acid; GTP Phosphohydrolases; Male; Membrane Proteins; Mice; Mice, Transgenic; Mitochondria; Mitochondrial Dynamics; Mitochondrial Proteins; Motor Neurons; Primary Cell Culture; Proteolysis; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord | 2015 |
Chronic glutamate treatment selectively modulates AMPA RNA editing and ADAR expression and activity in primary cortical neurons.
Topics: Adenosine Deaminase; Animals; Calcium; Calpain; Cell Line; Cell Survival; Glutamic Acid; Membrane Proteins; Neurons; Primary Cell Culture; Rats, Sprague-Dawley; Receptors, AMPA; RNA, Messenger | 2015 |
Brain ischemia downregulates the neuroprotective GDNF-Ret signaling by a calpain-dependent mechanism in cultured hippocampal neurons.
Topics: Animals; Brain Ischemia; Calpain; Cells, Cultured; Glial Cell Line-Derived Neurotrophic Factor; Glutamic Acid; Hippocampus; Humans; Mice; Neurons; Proto-Oncogene Proteins c-ret; Rats; Signal Transduction | 2015 |
Calpain inhibitor PD150606 attenuates glutamate induced spiral ganglion neuron apoptosis through apoptosis inducing factor pathway in vitro.
Topics: Acrylates; Amino Acid Chloromethyl Ketones; Animals; Animals, Newborn; Apoptosis; Apoptosis Inducing Factor; Calpain; Caspase Inhibitors; Caspases; Cell Nucleus; Gene Expression Regulation; Glutamic Acid; Glycoproteins; Mitochondria; Neurons; Primary Cell Culture; Protein Transport; Rats; Rats, Sprague-Dawley; Signal Transduction; Spiral Ganglion | 2015 |
Apoptosis-inducing factor and calpain upregulation in glutamate-induced injury of rat spiral ganglion neurons.
Topics: Animals; Apoptosis Inducing Factor; Calpain; Caspase 3; Cell Nucleus; Cells, Cultured; Evoked Potentials, Auditory, Brain Stem; Female; Glutamic Acid; Microscopy, Electron, Transmission; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Spiral Ganglion; Up-Regulation | 2015 |
Gephyrin Cleavage in In Vitro Brain Ischemia Decreases GABAA Receptor Clustering and Contributes to Neuronal Death.
Topics: Animals; Brain Ischemia; Calpain; Carrier Proteins; Cell Death; Cells, Cultured; Down-Regulation; Glucose; Glutamic Acid; Male; Membrane Proteins; Mice, Inbred C57BL; Neurons; Neurotoxins; Oxygen; Rats, Wistar; Receptors, GABA-A; Synapses | 2016 |
Effect of Melatonin on Glutamate: BDNF Signaling in the Cerebral Cortex of Polychlorinated Biphenyls (PCBs)-Exposed Adult Male Rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Calcium Channels, N-Type; Calpain; Cerebral Cortex; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Glutamic Acid; Male; Melatonin; Polychlorinated Biphenyls; Rats; Receptors, Glutamate; RNA, Messenger; Signal Transduction | 2015 |
Reduction of glutamate-induced excitotoxicity in murine primary neurons involving calpain inhibition.
Topics: alpha 1-Antitrypsin; Analysis of Variance; Animals; Calpain; Caspase 3; Cell Survival; Cells, Cultured; Cerebral Cortex; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acids; Glutamic Acid; Mice; Neurons; Phosphotransferases; Time Factors | 2015 |
Effect of glutamate on lysosomal membrane permeabilization in primary cultured cortical neurons.
Topics: Animals; Calpain; Cell Membrane Permeability; Cells, Cultured; Cerebral Cortex; Glutamic Acid; Lysosomes; Neurons; Primary Cell Culture; Rats, Sprague-Dawley; Reactive Oxygen Species | 2016 |
Glutamate protects against Ca(2+) paradox-induced injury and inhibits calpain activity in isolated rat hearts.
Topics: Animals; Calcium; Calpain; Cardiotonic Agents; Glutamic Acid; Heart; Male; Myocardial Reperfusion Injury; Organ Culture Techniques; Rats; Rats, Sprague-Dawley | 2016 |
Neuropeptide Y Y2 and Y5 receptors as promising targets for neuroprotection in primary neurons exposed to oxygen-glucose deprivation and in transient focal cerebral ischemia in rats.
Topics: Animals; Brain; Calpain; Cell Hypoxia; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Gait; Glucose; Glutamic Acid; Ischemic Attack, Transient; Male; Mice; Neurons; Neuroprotection; Neuroprotective Agents; Random Allocation; Rats, Sprague-Dawley; Receptors, Neuropeptide Y | 2017 |
[Peptide drug cortexin inhibits brain caspase-8].
Topics: Animals; Brain; Brain Chemistry; Calpain; Caspase 1; Caspase 3; Caspase 8; Caspase 9; Cathepsin B; Cattle; Cell Death; Excitatory Amino Acid Antagonists; Gene Expression; Glutamic Acid; Neurons; Neuroprotective Agents; Primary Cell Culture; Protease Inhibitors; Protein Hydrolysates; Rats; Rats, Wistar | 2017 |
Aquilariae Lignum extract attenuates glutamate-induced neuroexcitotoxicity in HT22 hippocampal cells.
Topics: Animals; Apoptosis; Calcium Signaling; Calpain; Cell Line; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Mice; Neurons; Neuroprotective Agents; Phytotherapy; Plant Extracts; Plants, Medicinal; Reactive Oxygen Species; Thymelaeaceae; Time Factors | 2018 |
Calpain2 but not calpain1 mediated by calpastatin following glutamate-induced regulated necrosis in rat retinal neurons.
Topics: Animals; Calpain; Disease Models, Animal; Glutamic Acid; Necrosis; Rats; Rats, Sprague-Dawley; Retinal Neurons | 2019 |
Calpain-dependent Beclin1 cleavage stimulates senescence-associated cell death in HT22 hippocampal cells under the oxidative stress conditions.
Topics: Animals; Apoptosis; Beclin-1; Calpain; Caspases; Cell Line; Cell Survival; Cellular Senescence; Glutamic Acid; HeLa Cells; Hippocampus; Humans; Leupeptins; Mice; Neurons; NIH 3T3 Cells; Oxidative Stress; Reactive Oxygen Species | 2019 |
Excitotoxic targeting of Kidins220 to the Golgi apparatus precedes calpain cleavage of Rap1-activation complexes.
Topics: Animals; Calpain; Cell Death; Cells, Cultured; Endocytosis; Endosomes; Glutamic Acid; Golgi Apparatus; Membrane Proteins; Mitogen-Activated Protein Kinase 3; Neurons; Phosphoproteins; rab5 GTP-Binding Proteins; rap1 GTP-Binding Proteins; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2019 |
Activity-dependent cleavage of dyskinesia-related proline-rich transmembrane protein 2 (PRRT2) by calpain in mouse primary cortical neurons.
Topics: Amino Acid Sequence; Animals; Calpain; Cells, Cultured; Cerebral Cortex; Dyskinesias; Glutamic Acid; Male; Membrane Potentials; Membrane Proteins; Mice; Nerve Tissue Proteins; Neurons; Plasmids | 2020 |
Calpain-mediated cleavage of Fbxw7 during excitotoxicity.
Topics: Animals; Calpain; Cell Death; Cerebral Cortex; Cyclin-Dependent Kinase 5; F-Box-WD Repeat-Containing Protein 7; Glutamic Acid; Infarction, Middle Cerebral Artery; Neurons; Rats | 2020 |
Lentiviral expression of calpain-1 C2-like domain peptide prevents glutamate-induced cell death in mouse hippocampal neuronal HT22 cells.
Topics: Animals; Apoptosis Inducing Factor; Calpain; Cell Death; Glutamic Acid; Hippocampus; Mice; Oxidative Stress; Peptides | 2022 |
Calpain-Independent Intracellular Protease Activity Is Elevated in Excitotoxic Cortical Neurons Prior to Delayed Calcium Deregulation and Mitochondrial Dysfunction.
Topics: Animals; Calcium; Calpain; Cells, Cultured; Glutamic Acid; Mitochondria; Neurons; Peptide Hydrolases; Proteolysis; Rats | 2022 |
Role of CAST-Drp1 Pathway in Retinal Neuron-Regulated Necrosis in Experimental Glaucoma.
Topics: Animals; Calpain; Dynamins; Glaucoma; Glutamic Acid; Necrosis; Rats; Retinal Neurons | 2023 |
Morin post-treatment surpassed calpeptin in ameliorating 3-NP-induced cortical neurotoxicity via modulation of glutamate/calpain axis, Kidins220, and BDNF/TrkB/AKT/CREB trajectory.
Topics: Animals; Antioxidants; Brain-Derived Neurotrophic Factor; Calpain; Cyclic AMP Response Element-Binding Protein; Flavonoids; Glutamic Acid; Membrane Proteins; Neuroprotective Agents; Phosphoproteins; Proto-Oncogene Proteins c-akt; Rats | 2023 |
N-Terminomic Changes in Neurons During Excitotoxicity Reveal Proteolytic Events Associated With Synaptic Dysfunctions and Potential Targets for Neuroprotection.
Topics: Animals; Calpain; Cells, Cultured; Glutamic Acid; Mice; Nervous System Diseases; Neurons; Neuroprotection; Proteolysis; Rats | 2023 |