Compounds > glutamic acid

glutamic acid and 6-methyl-2-(phenylethynyl)pyridine

glutamic acid has been researched along with 6-methyl-2-(phenylethynyl)pyridine in 42 studies

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's31 (73.81)29.6817
2010's11 (26.19)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bräuner-Osborne, H; Egebjerg, J; Krogsgaard-Larsen, P; Madsen, U; Nielsen, EO1
Faden, AI; Movsesyan, V; O'Leary, DM; Vicini, S1
Pèzzola, A; Pintor, A; Popoli, P; Quarta, D; Reggio, R1
Bao, W; Faden, AI; Fan, L; Knoblach, SM; Movsesyan, VA; Mullins, PG; O'Leary, DM1
Chamberlain, M; Johnson, MP; Kelly, G1
Croucher, MJ; Gasparini, F; Jane, DE; Thomas, LS1
Bernardi, G; Bonsi, P; Calabresi, P; Centonze, D; Conquet, F; Gubellini, P; Picconi, B; Pisani, A1
Anderson, J; Correa, L; Lorrain, DS; Varney, M1
Ahn, JY; Huang, H; Kalman, D; Kapp, JA; Nagata, E; Rong, R; Snyder, SH; Tu, J; Worley, PF; Ye, K1
Gear, RW; Levine, JD; Tambeli, CH; Young, A1
Clinckers, R; Ebinger, G; Lindekens, H; Lodge, D; Meurs, A; Michotte, Y; O'Neill, MJ; Smolders, I1
De Berardinis, MA; Domenici, MR; Frank, C; Grieco, R; Martire, A; Massotti, M; Minghetti, L; Nazzicone, V; Pepponi, R; Pèzzola, A; Pintor, A; Popoli, P; Potenza, RL; Reggio, R; Tebano, MT1
Besheer, J; Hodge, CW1
Faden, AI; Lea, PM; Movsesyan, VA1
Battaglia, G; Capobianco, L; Cappuccio, I; De Vita, T; Desiderati, F; Melchiorri, D; Nicoletti, F; Porcellini, A; Spinsanti, P; Storto, M1
Alagille, D; Conn, PJ; Nong, Y; Rodriguez, AL; Sekaran, NK; Tamagnan, GD1
Miyatake, M; Nakamura, A; Narita, M; Shibasaki, M; Suzuki, T1
Hemptinne, I; Hermans, E; Maloteaux, JM; Tilleux, S; Vanhoutte, N; Vermeiren, C1
Hannun, RA; Kapasova, Z; Lominac, KD; Middaugh, LD; Patterson, C; Szumlinski, KK1
Dolan, S; Nolan, AM1
Du, D; Hu, Q; Jiang, W; Shen, Q; Xu, T; Xu, Y1
Cilia, J; Hatcher, P; Jones, DN; Reavill, C1
Dall'Olio, R; Gandolfi, O; Locchi, F; Rimondini, R1
Croucher, MJ; Datla, KP; Dexter, DT; Vernon, AC; Zbarsky, V1
Carroll, FI; Dewey, WL; Gabra, BH; Navarro, HA; Smith, FL1
Jesse, CR; Nogueira, CW; Rocha, JB; Savegnago, L1
Bray, SM; Chang, S; He, C; Jin, P; Li, Z; Warren, ST; Zarnescu, DC1
Jiang, ZZ; Liu, Y; Shang, J; Wang, S; Wang, W; Zhang, LY; Zhang, Z1
Dolińska, M; Grajkowska, E; Klauzińska, M; Luchenko, V; Pshenichkin, S; Wroblewski, JT1
Marek, GJ; Zhang, C1
Faria, LC; Fuortes, MG; Merlin, LR1
Bashir, ZI; Battaglia, G; Calò, L; Cinque, C; Eusebi, F; Maggi, L; Massey, PV; Melchiorri, D; Molinaro, G; Nicoletti, F; Piccinin, S1
Battaglia, G; Bruno, V; Di Menna, L; Molinaro, G; Nicoletti, F; Pescatori, L; Pietracupa, S; Usiello, A1
Allers, KA; Austin, VC; Blamire, AM; Lowe, AS; Matthews, PM; Schnupp, JW; Sibson, NR; Sloan, HL1
Murphy, TH; Scott, NA1
Emionite, L; Ikehata, M; Musante, I; Pittaluga, A; Puliti, A; Rastaldi, MP; Ravazzolo, R; Rossi, PI; Summa, M1
Conn, PJ; Gregory, KJ; Lindsley, CW; Meiler, J; Nguyen, ED; Reiff, SD; Squire, EF; Stauffer, SR1
Hirouchi, M; Oka, M; Oyama, T; Sugahara, S; Tamura, M1
Kinouchi, M; Kuribayashi, N; Miyamoto, Y; Nagai, H; Takamaru, N; Tamatani, T; Uchida, D1
Bengston, CP; Irmady, K; Narayanan, KL; Subramaniam, S; Unsicker, K; von Bohlen und Halbach, O1
Bianchi, E; Cerretani, D; Ghelardini, C; Menicacci, C1
Bi, GH; Gardner, EL; He, Y; Jordan, CJ; Li, J; Li, X; Peng, XQ; Xi, ZX; Yang, HJ; Zhang, HY1

Reviews

1 review(s) available for glutamic acid and 6-methyl-2-(phenylethynyl)pyridine

ArticleYear
Ligands for glutamate receptors: design and therapeutic prospects.
    Journal of medicinal chemistry, 2000, Jul-13, Volume: 43, Issue:14

    Topics: Animals; Drug Design; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Ligands; N-Methylaspartate; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Synapses

2000

Other Studies

41 other study(ies) available for glutamic acid and 6-methyl-2-(phenylethynyl)pyridine

ArticleYear
Selective mGluR5 antagonists MPEP and SIB-1893 decrease NMDA or glutamate-mediated neuronal toxicity through actions that reflect NMDA receptor antagonism.
    British journal of pharmacology, 2000, Volume: 131, Issue:7

    Topics: Animals; Cell Death; Cells, Cultured; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Fetus; Glutamic Acid; Glycine; Hydrolysis; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Phenylacetates; Phosphatidylinositols; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate

2000
The mGlu5 receptor agonist CHPG stimulates striatal glutamate release: possible involvement of A2A receptors.
    Neuroreport, 2000, Nov-09, Volume: 11, Issue:16

    Topics: Animals; Corpus Striatum; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Male; Microdialysis; Neuroprotective Agents; Phenylacetates; Pyridines; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, Purinergic P1; Triazoles

2000
mGluR5 antagonists 2-methyl-6-(phenylethynyl)-pyridine and (E)-2-methyl-6-(2-phenylethenyl)-pyridine reduce traumatic neuronal injury in vitro and in vivo by antagonizing N-methyl-D-aspartate receptors.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 296, Issue:1

    Topics: Animals; Brain Injuries; Cell Survival; Cells, Cultured; Cerebral Cortex; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Hydrolysis; Male; Maze Learning; Memory; N-Methylaspartate; Neurons; Neuroprotective Agents; Phosphatidylinositols; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate

2001
Changes in rat serum corticosterone after treatment with metabotropic glutamate receptor agonists or antagonists.
    Journal of neuroendocrinology, 2001, Volume: 13, Issue:8

    Topics: Adrenalectomy; Adrenocorticotropic Hormone; Amino Acids; Animals; Benzoates; Bridged Bicyclo Compounds; Corticosterone; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Male; Neuroprotective Agents; Paraventricular Hypothalamic Nucleus; Phenylacetates; Propionates; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Xanthenes

2001
Glutamate release inhibiting properties of the novel mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP): complementary in vitro and in vivo evidence.
    Neuropharmacology, 2001, Volume: 41, Issue:4

    Topics: Animals; Brain Chemistry; Electric Stimulation; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; In Vitro Techniques; Male; Microdialysis; Pyridines; Rats; Rats, Wistar; Receptors, Kainic Acid; Resorcinols

2001
Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons.
    Neuroscience, 2001, Volume: 106, Issue:3

    Topics: (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride; Action Potentials; Animals; Anticonvulsants; Benzoates; Cyclopropanes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Mice; Mice, Knockout; Muscarine; Muscarinic Agonists; N-Methylaspartate; Neostriatum; Neurons; Phenylacetates; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Resorcinols; Synaptic Transmission

2001
Activation of spinal group I metabotropic glutamate receptors in rats evokes local glutamate release and spontaneous nociceptive behaviors: effects of 2-methyl-6-(phenylethynyl)-pyridine pretreatment.
    Neuroscience letters, 2002, Jul-26, Volume: 327, Issue:3

    Topics: Animals; Behavior, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Glycine; Male; Microdialysis; Pain; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Resorcinols; Spinal Cord; Time Factors

2002
PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis.
    Nature neuroscience, 2003, Volume: 6, Issue:11

    Topics: Adenoviridae; Amino Acid Motifs; Amino Acid Sequence; Analysis of Variance; Androstadienes; Animals; Apoptosis; Blotting, Western; Brain; Carrier Proteins; Cell Fractionation; Cells, Cultured; Cloning, Molecular; DNA Fragmentation; Embryo, Mammalian; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Homer Scaffolding Proteins; Humans; Immunohistochemistry; In Vitro Techniques; Kidney; Leucine; Molecular Sequence Data; Mutation; Nerve Tissue Proteins; Neurons; Neuropeptides; Phosphatidylinositol 3-Kinases; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Precipitin Tests; Proline; Protein Binding; Proteins; Proto-Oncogene Proteins c-myc; Pyridines; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staurosporine; Subcellular Fractions; Synaptophysin; Transfection; Wortmannin

2003
Contribution of spinal glutamatergic mechanisms in heterosegmental antinociception induced by noxious stimulation.
    Pain, 2003, Volume: 106, Issue:1-2

    Topics: Animals; Benzoates; Capsaicin; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Isoquinolines; Male; Nociceptors; Pyridines; Quinoxalines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Spinal Cord; Stimulation, Chemical; Substance P

2003
In vivo modulation of extracellular hippocampal glutamate and GABA levels and limbic seizures by group I and II metabotropic glutamate receptor ligands.
    Journal of neurochemistry, 2004, Volume: 88, Issue:5

    Topics: Amino Acids; Animals; Anticonvulsants; Benzoates; Bridged Bicyclo Compounds, Heterocyclic; Cyclopropanes; Disease Models, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Fluid; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Ligands; Limbic System; Male; Microdialysis; Pilocarpine; Pyridines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Seizures

2004
Neuroprotective effects of the mGlu5R antagonist MPEP towards quinolinic acid-induced striatal toxicity: involvement of pre- and post-synaptic mechanisms and lack of direct NMDA blocking activity.
    Journal of neurochemistry, 2004, Volume: 89, Issue:6

    Topics: Animals; Body Weight; Calcium; Cells, Cultured; Electroencephalography; Excitatory Amino Acid Antagonists; Glutamic Acid; L-Lactate Dehydrogenase; Male; Maze Learning; Microdialysis; N-Methylaspartate; Neostriatum; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Neurotoxins; Pyridines; Quinolinic Acid; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate

2004
Pharmacological and anatomical evidence for an interaction between mGluR5- and GABA(A) alpha1-containing receptors in the discriminative stimulus effects of ethanol.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:4

    Topics: Alcoholism; Animals; Diazepam; Discrimination, Psychological; Disease Models, Animal; Drug Interactions; Ethanol; Excitatory Amino Acid Antagonists; GABA Modulators; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Male; Neurons; Pentobarbital; Pyridines; Rats; Rats, Long-Evans; Receptor, Metabotropic Glutamate 5; Receptors, GABA-A; Receptors, Metabotropic Glutamate; Synaptic Transmission; Telencephalon

2005
Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors.
    British journal of pharmacology, 2005, Volume: 145, Issue:4

    Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Etoposide; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; Hydrolysis; Male; Membrane Potentials; Mice; Mice, Knockout; N-Methylaspartate; Neurons; Neuroprotective Agents; Phenylacetates; Phosphatidylinositols; Pyridines; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Thiazoles

2005
Endogenous activation of mGlu5 metabotropic glutamate receptors supports self-renewal of cultured mouse embryonic stem cells.
    Neuropharmacology, 2005, Volume: 49 Suppl 1

    Topics: Alanine Transaminase; Animals; Blotting, Northern; Blotting, Western; Brain; Calcium; Cell Differentiation; Cells, Cultured; Chromatography, High Pressure Liquid; Drug Interactions; Embryo, Mammalian; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Flow Cytometry; Gene Expression Regulation, Developmental; Glutamic Acid; Interleukin-6; Leukemia Inhibitory Factor; Mice; Neurons; Oligodeoxyribonucleotides, Antisense; Pyridines; Quisqualic Acid; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stem Cells; Thymidine; Time Factors; Tritium

2005
A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamate receptor subtype 5 and blocks the effects of multiple allosteric modulators.
    Molecular pharmacology, 2005, Volume: 68, Issue:6

    Topics: Alkynes; Allosteric Regulation; Allosteric Site; Animals; Brain; Cell Line, Tumor; Drug Interactions; Electrophysiology; Glutamic Acid; Humans; Ligands; Neurons; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Transfection

2005
Glutamatergic neurotransmission and protein kinase C play a role in neuron-glia communication during the development of methamphetamine-induced psychological dependence.
    The European journal of neuroscience, 2005, Volume: 22, Issue:6

    Topics: Amphetamine-Related Disorders; Animals; Astrocytes; Calcium; Cell Communication; Central Nervous System Stimulants; Coculture Techniques; Conditioning, Operant; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Immunohistochemistry; Male; Methamphetamine; Mice; Mice, Inbred ICR; Microscopy, Confocal; Neuroglia; Neurons; Piperidines; Pregnancy; Protein Kinase C; Pyridines; Quinoxalines; Receptors, Glutamate; Synaptic Transmission

2005
Loss of metabotropic glutamate receptor-mediated regulation of glutamate transport in chemically activated astrocytes in a rat model of amyotrophic lateral sclerosis.
    Journal of neurochemistry, 2006, Volume: 96, Issue:3

    Topics: Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Aspartic Acid; Astrocytes; Blotting, Northern; Calcium; Carbachol; Cholinergic Agonists; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutamic Acid; Humans; Immunohistochemistry; Male; Methoxyhydroxyphenylglycol; Protein Kinase C; Pyridines; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium; Superoxide Dismutase; Tritium

2006
Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: potential insight into their anti-addictive properties.
    Drug and alcohol dependence, 2006, Nov-08, Volume: 85, Issue:2

    Topics: Alcohol Deterrents; Alcoholism; Animals; Chromones; Conditioning, Classical; Dopamine; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mice; Mice, Inbred C57BL; Motor Activity; Nucleus Accumbens; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate

2006
Blockade of metabotropic glutamate receptor 5 activation inhibits mechanical hypersensitivity following abdominal surgery.
    European journal of pain (London, England), 2007, Volume: 11, Issue:6

    Topics: Afferent Pathways; Animals; Disease Models, Animal; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Hyperalgesia; Laparotomy; Neurons, Afferent; Nociceptors; Pain Measurement; Pain Threshold; Pain, Postoperative; Presynaptic Terminals; Pyridines; Rats; Rats, Wistar; Reaction Time; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Synaptic Transmission

2007
Role of spinal metabotropic glutamate receptor subtype 5 in the development of tolerance to morphine-induced antinociception in rat.
    Neuroscience letters, 2007, Jun-13, Volume: 420, Issue:2

    Topics: Analgesics, Opioid; Animals; Calcium; Drug Administration Schedule; Drug Tolerance; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Injections, Spinal; Male; Morphine; Neurons, Afferent; Nociceptors; Pain; Pain Threshold; Phenylacetates; Protein Kinase C; Pyridines; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Spinal Cord; Synaptic Transmission; Up-Regulation

2007
(+/-) Ketamine-induced prepulse inhibition deficits of an acoustic startle response in rats are not reversed by antipsychotics.
    Journal of psychopharmacology (Oxford, England), 2007, Volume: 21, Issue:3

    Topics: Animals; Antipsychotic Agents; Clozapine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Haloperidol; Ketamine; Lamotrigine; Male; Pyridines; Rats; Rats, Sprague-Dawley; Reflex, Startle; Risperidone; Schizophrenia; Sulfonamides; Thiophenes; Triazines

2007
Water T-maze, an improved method to assess spatial working memory in rats: Pharmacological validation.
    Neuroscience letters, 2007, Jul-18, Volume: 422, Issue:3

    Topics: Animals; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Maze Learning; Memory; Muscarinic Antagonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Scopolamine

2007
Subtype selective antagonism of substantia nigra pars compacta Group I metabotropic glutamate receptors protects the nigrostriatal system against 6-hydroxydopamine toxicity in vivo.
    Journal of neurochemistry, 2007, Volume: 103, Issue:3

    Topics: Animals; Benzoates; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Male; Molecular Structure; Nerve Degeneration; Neural Pathways; Neuroprotective Agents; Neurotoxins; Oxidopamine; Parkinsonian Disorders; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Substantia Nigra; Treatment Outcome; Tyrosine 3-Monooxygenase

2007
mGluR5 antagonists that block calcium mobilization in vitro also reverse (S)-3,5-DHPG-induced hyperalgesia and morphine antinociceptive tolerance in vivo.
    Brain research, 2008, Jan-02, Volume: 1187

    Topics: Analgesics, Opioid; Animals; Calcium Signaling; Central Nervous System; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hyperalgesia; Male; Mice; Morphine; Nociceptors; Pain; Placebo Effect; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Synaptic Transmission

2008
Neuroprotective effect caused by MPEP, an antagonist of metabotropic glutamate receptor mGluR5, on seizures induced by pilocarpine in 21-day-old rats.
    Brain research, 2008, Mar-10, Volume: 1198

    Topics: Acetylcholinesterase; Animals; Brain; Convulsants; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Muscarinic Agonists; Nerve Degeneration; Neuroprotective Agents; Oxidative Stress; Pilocarpine; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Synaptic Transmission; Treatment Outcome

2008
Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila.
    Nature chemical biology, 2008, Volume: 4, Issue:4

    Topics: Animals; Disease Models, Animal; Drosophila; Drosophila Proteins; Drug Evaluation, Preclinical; Female; Fragile X Mental Retardation Protein; Fragile X Syndrome; gamma-Aminobutyric Acid; Glutamic Acid; Male; Molecular Weight; Mutation; Phenotype; Pyridines; RNA, Messenger; Small Molecule Libraries

2008
Activation of group I metabotropic glutamate receptors induces long-term depression in the hippocampal CA1 region of adult rats in vitro.
    Neuroscience research, 2008, Volume: 62, Issue:1

    Topics: Age Factors; Aging; Animals; Axons; Benzoates; Electric Stimulation; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hippocampus; Long-Term Synaptic Depression; Neural Inhibition; Neural Pathways; Neurons; Organ Culture Techniques; Pyridines; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Synaptic Membranes; Synaptic Transmission

2008
Dual neurotoxic and neuroprotective role of metabotropic glutamate receptor 1 in conditions of trophic deprivation - possible role as a dependence receptor.
    Neuropharmacology, 2008, Volume: 55, Issue:4

    Topics: Animals; Cell Survival; Cells, Cultured; Cerebellum; Cerebral Cortex; Chromones; Dioxolanes; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression; Glutamic Acid; Green Fluorescent Proteins; Intercellular Signaling Peptides and Proteins; Mice; Neurons; Potassium Chloride; Purines; Pyridines; Rats; Receptors, Metabotropic Glutamate; RNA, Small Interfering; Time Factors; Transfection

2008
Activation of metabotropic glutamate 5 (mGlu5) receptors induces spontaneous excitatory synaptic currents in layer V pyramidal cells of the rat prefrontal cortex.
    Neuroscience letters, 2008, Sep-19, Volume: 442, Issue:3

    Topics: Animals; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Methoxyhydroxyphenylglycol; Organ Culture Techniques; Patch-Clamp Techniques; Prefrontal Cortex; Pyramidal Cells; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Synapses; Synaptic Transmission

2008
Impact of protein kinase C activation on epileptiform activity in the hippocampal slice.
    Epilepsy research, 2008, Volume: 82, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; Action Potentials; Animals; Atropine; Benzoates; Benzophenanthridines; Enzyme Activation; Epilepsy; Glutamic Acid; Glycine; Guinea Pigs; Hippocampus; In Vitro Techniques; Neurotransmitter Agents; Phorbol 12,13-Dibutyrate; Picrotoxin; Protein Kinase C; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Signal Transduction

2008
Interaction between Ephrins and mGlu5 metabotropic glutamate receptors in the induction of long-term synaptic depression in the hippocampus.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Feb-24, Volume: 30, Issue:8

    Topics: Animals; Ephrin-B1; Ephrins; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; Long-Term Synaptic Depression; Male; Organ Culture Techniques; Patch-Clamp Techniques; Pyridines; Rats; Rats, Wistar; Receptor, EphB1; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Recombinant Fusion Proteins; Synaptic Transmission

2010
D-aspartate activates mGlu receptors coupled to polyphosphoinositide hydrolysis in neonate rat brain slices.
    Neuroscience letters, 2010, Jul-12, Volume: 478, Issue:3

    Topics: Animals; Animals, Newborn; Brain; Cerebral Cortex; D-Aspartic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Hydrolysis; In Vitro Techniques; Phosphatidylinositol Phosphates; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate

2010
Regional differences in neurovascular coupling in rat brain as determined by fMRI and electrophysiology.
    NeuroImage, 2010, Nov-01, Volume: 53, Issue:2

    Topics: Animals; Astrocytes; Blood Pressure; Brain; Cerebral Cortex; Cerebrovascular Circulation; Electric Stimulation; Electroencephalography; Evoked Potentials; Excitatory Amino Acid Antagonists; Glutamic Acid; Magnetic Resonance Imaging; Neurons; Oxygen; Pyridines; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Signal Transduction

2010
Hemodynamic responses evoked by neuronal stimulation via channelrhodopsin-2 can be independent of intracortical glutamatergic synaptic transmission.
    PloS one, 2012, Volume: 7, Issue:1

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cerebral Cortex; Channelrhodopsins; Dizocilpine Maleate; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Agents; Glutamic Acid; Hemodynamics; Lasers; Mice; Neurons; Pyridines; Regional Blood Flow; Synaptic Transmission

2012
Compensatory molecular and functional mechanisms in nervous system of the Grm1(crv4) mouse lacking the mGlu1 receptor: a model for motor coordination deficits.
    Cerebral cortex (New York, N.Y. : 1991), 2013, Volume: 23, Issue:9

    Topics: Animals; Brain; Disease Models, Animal; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Male; Mice; Mice, Inbred BALB C; Movement Disorders; Mutation; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Synaptosomes

2013
Probing the metabotropic glutamate receptor 5 (mGlu₅) positive allosteric modulator (PAM) binding pocket: discovery of point mutations that engender a "molecular switch" in PAM pharmacology.
    Molecular pharmacology, 2013, Volume: 83, Issue:5

    Topics: Alkynes; Allosteric Regulation; Allosteric Site; Amino Acids; Animals; Cell Line; Glutamic Acid; HEK293 Cells; Humans; Ligands; Point Mutation; Pyridines; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Transfection

2013
Acamprosate {monocalcium bis(3-acetamidopropane-1-sulfonate)} reduces ethanol-drinking behavior in rats and glutamate-induced toxicity in ethanol-exposed primary rat cortical neuronal cultures.
    European journal of pharmacology, 2013, Oct-15, Volume: 718, Issue:1-3

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acamprosate; Alcohol Drinking; Animals; Behavior, Animal; Cells, Cultured; Cerebral Cortex; Dizocilpine Maleate; Ethanol; Glutamic Acid; Lactate Dehydrogenases; Male; Neurons; Neuroprotective Agents; Neurotoxins; Nifedipine; Pyridines; Rats; Rats, Wistar; Signal Transduction; Taurine

2013
The role of metabotropic glutamate receptor 5 on the stromal cell-derived factor-1/CXCR4 system in oral cancer.
    PloS one, 2013, Volume: 8, Issue:11

    Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemokine CXCL12; Disease Models, Animal; Gene Expression; Gene Expression Regulation, Neoplastic; Glutamic Acid; Humans; Mice; Mouth Neoplasms; Neoplasm Metastasis; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, CXCR4; Thiazoles

2013
Role of transient receptor potential channel 1 (TRPC1) in glutamate-induced cell death in the hippocampal cell line HT22.
    Journal of molecular neuroscience : MN, 2014, Volume: 52, Issue:3

    Topics: Animals; Cell Death; Cell Line; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hippocampus; Mice; Neurons; Phenylacetates; Pyridines; Receptor, Metabotropic Glutamate 5; RNA, Messenger; TRPC Cation Channels

2014
Spinal administration of mGluR5 antagonist prevents the onset of bortezomib induced neuropathic pain in rat.
    Neuropharmacology, 2014, Volume: 86

    Topics: Analgesics; Animals; Boronic Acids; Bortezomib; Ceftriaxone; Cell Line, Tumor; Cell Survival; Central Nervous System Agents; Disease Models, Animal; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Hyperalgesia; Injections, Spinal; Male; Neural Conduction; Neuralgia; Peripheral Nervous System Diseases; Pyrazines; Pyridines; Random Allocation; Rats; Receptor, Metabotropic Glutamate 5

2014
mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism.
    Scientific reports, 2018, 02-27, Volume: 8, Issue:1

    Topics: Animals; Cocaine; Dopamine; Drug-Seeking Behavior; Glutamic Acid; Male; Nucleus Accumbens; Pyridines; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Self Administration

2018