glutamic acid has been researched along with 1-amino-1,3-dicarboxycyclopentane in 213 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 170 (79.81) | 18.2507 |
| 2000's | 41 (19.25) | 29.6817 |
| 2010's | 2 (0.94) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Allgeier, H; Knöpfel, T; Kuhn, R | 1 |
| Laurie, DJ; Schoeffter, P; Sommer, B; Wiederhold, KH | 1 |
| Arnold, JS; Belagaje, RM; Burgett, SG; Johnson, BG; Rockey, PK; Rosteck, PR; Schoepp, DD; Wright, RA; Wu, S | 1 |
| Araldi, GL; Kozikowski, AP; Pshenichkin, S; Steensma, D; Surina, E; Tückmantel, W; Wang, S; Wroblewski, JT | 1 |
| Acher, FC; Brabet, I; Jullian, N; Pin, JP | 1 |
| Araldi, GL; Kozikowski, AP; Pshenichkin, S; Surina, E; Tückmantel, W; Wroblewski, JT | 1 |
| Costantino, G; Macchiarulo, A; Pellicciari, R | 1 |
| Arnold, MB; Johnson, BG; Ornstein, PL; Schoepp, DD; Wheeler, WJ; Wright, RA | 1 |
| Bräuner-Osborne, H; Egebjerg, J; Krogsgaard-Larsen, P; Madsen, U; Nielsen, EO | 1 |
| Adam, G; Bleuel, Z; Chaboz, S; Ellis, GJ; Faull, RL; Malherbe, P; Messer, J; Metzler, V; Mutel, V; Nilly, A; Richards, JG; Roughley, BS; Schlaeger, EJ | 1 |
| Arnold, MB; Ornstein, PL; Schoepp, DD; Wheeler, WJ; Wright, RA | 1 |
| Blanco-Urgoiti, J; Collado, I; Espinosa, JF; Johnson, BG; Kingston, AE; Mazón, A; Pedregal, C; Schoepp, DD; Wright, RA | 1 |
| Bischoff, F; Janssen, C; Langlois, X; Lavreysen, H; Lesage, AS; Leysen, JE | 1 |
| Garashchuk, OV; Koval'chuk, IuN; Kryshtal', OA | 1 |
| Conn, PJ; Winder, DG | 1 |
| Bockaert, J; Curry, K; Homburger, V; Manzoni, O; Prezeau, L; Sladeczek, F | 1 |
| Bernardi, G; Calabresi, P; Mercuri, NB | 1 |
| Rainnie, DG; Shinnick-Gallagher, P | 1 |
| Crill, W; Greene, C; Schwindt, P | 1 |
| Herrero, I; Miras-Portugal, MT; Sánchez-Prieto, J | 1 |
| Boss, V; Conn, PJ; Desai, MA; Smith, TS | 1 |
| Bleakman, D; Chard, PS; Glaum, SR; Miller, RJ; Rusin, KI | 1 |
| Gähwiler, BH; Gerber, U | 1 |
| Charpak, S; Gähwiler, BH | 1 |
| Bredt, DS; Hwang, PM; Snyder, SH | 1 |
| Bockaert, J; Dumuis, A; Oomagari, K; Pin, JP; Sebben, M | 1 |
| Herrero, I; Miras-Portugal, MT; Sánchez-Prieto, J; Vázquez, E | 2 |
| MacDermott, AB; Reichling, DB | 1 |
| Miller, RF; Thoreson, WB | 1 |
| Glowinski, J; Prémont, J; Stella, N; Tencé, M | 1 |
| Johnson, BG; Schoepp, DD | 2 |
| Herrera, AJ; Osborne, NN | 1 |
| Amico, C; Condorelli, DF; Dell'Albani, P; Giuffrida-Stella, AM; Kaczmarek, L; Lukasiuk, K | 1 |
| Cavanni, P; Eistetter, H; Ferraguti, F; Ratti, E; Salvagno, C; Trist, DG | 1 |
| Mikuni, M; Saitoh, K; Shinno, H; Takahashi, K; Tomita, U; Yamawaki, S | 1 |
| Collins, DR; Davies, SN | 1 |
| Devillers, JP; Simonnet, G | 1 |
| Hansson, E; Johansson, BB; Rönnbäck, L; Westergren, I | 1 |
| Dowling, JE; Grant, GB | 1 |
| Acciarri, N; Beani, L; Bianchi, C; Calo, G; Fabrizi, A; Ferraro, L; Morari, M; Piazza, G | 1 |
| McCarthy, KD; Porter, JT | 1 |
| Brune, T; Deitmer, JW | 1 |
| Chung, SH; Premkumar, L | 1 |
| Brotchie, JM; East, SJ; Hill, MP | 1 |
| Cox, AJ; Lee, RK; Nitsch, RM; Wurtman, RJ | 1 |
| Glaum, SR; Miller, RJ | 1 |
| Alagarsamy, S; Johnson, KM; Lonart, G | 1 |
| Catania, MV; Hollingsworth, Z; Penney, JB; Young, AB | 1 |
| Neale, JH; Saab, OH; Wroblewska, B; Wroblewski, JT | 1 |
| Naarala, J; Nykvist, P; Savolainen, K; Tuomala, M | 1 |
| Klockgether, T; Turski, L | 1 |
| Bau, A; Faarup, P; Foged, C; Kanstrup, A; Suzdak, PD; Thomsen, C | 1 |
| Bockaert, J; Brabet, I; Curry, K; Gomeza, J; Joly, C; Pin, JP | 1 |
| Lachica, EA; Rubel, EW; Zirpel, L | 1 |
| Bridges, RJ; Chamberlin, AR; Cotman, CW; Miller, S | 1 |
| Lynch, MA; McGahon, B | 2 |
| Devau, G; Lehouelleur, J; Sans, A | 1 |
| Bigl, V; Grantyn, R; Rothe, T | 1 |
| Birrell, GJ; Gordon, MP; Marcoux, FW | 1 |
| Scholz, WK | 1 |
| Esposito, E; Gorbunov, N | 1 |
| Catt, KJ; Krsmanovic, LZ; Spergel, DJ; Stojilkovic, SS | 1 |
| Akaike, N; Harata, N; Shirasaki, T | 1 |
| McDonald, JW; Schoepp, DD; Wright, RA | 1 |
| Hansson, E | 1 |
| Cornell-Bell, AH; Kim, WT; Rioult, MG | 1 |
| Littman, L; Robinson, MB | 1 |
| Coffey, ET; Herrero, I; Nicholls, DG; Sánchez-Prieto, J; Sihra, TS | 1 |
| Hansen, L; Suzdak, PD; Thomsen, C | 1 |
| Bockaert, J; Chavis, P; Fagni, L; Shinozaki, H | 1 |
| Berrino, L; Calderaro, V; D'Amico, M; Maione, S; Pizzirusso, A; Rossi, F; Vitagliano, S | 1 |
| Rodnight, R; Wofchuk, ST | 1 |
| Gabellini, N; Manev, H; Manev, RM | 1 |
| Katz, PS; Levitan, IB | 1 |
| Ueda, T; Winter, HC | 2 |
| Aronica, E; Balázs, R; Condorelli, DF; Nicoletti, F | 1 |
| Cotman, CW; Kahle, JS | 1 |
| Glatt, BS; Littman, L; Robinson, MB | 1 |
| Arrighi, V; Fallacara, C; Memo, M; Pizzi, M; Spano, PF | 1 |
| Masu, M; Nakanishi, S; Takahashi, K; Tanabe, Y; Tsuchida, K | 1 |
| Cappel, E; Holler, T; Klein, J; Löffelholz, K | 1 |
| De Bernardi, R; Ferro, F; Fontana, G; Gemignani, A; Raiteri, M | 1 |
| Chase, LA; Garlin, AB; Johnson, RL; Koerner, JF; Littman, L; Renzi, M; Robinson, MB | 1 |
| Morishita, W; Sastry, BR; Shew, TR | 1 |
| DaSilva, AM; Gillis, RA; McManigle, JE; Panico, WH | 1 |
| Eriksson, G; Iverfeldt, K; Peterson, A; Walum, E | 1 |
| Attwell, PJ; Bradford, HF; Croucher, MJ; Jane, DE; Kaura, S; Sigala, G; Watkins, JC | 1 |
| Arrighi, V; Consolandi, O; Galli, P; Memo, M; Pizzi, M; Spano, PF | 1 |
| Benz, A; Mennerick, S; Zorumski, CF | 1 |
| Akhondzadeh, S; Stone, TW | 1 |
| Gilbert, E; Grimwood, S; Hutson, PH; Ragan, CI | 1 |
| Burnett, JP; Johnson, BG; Mann, A; Mayne, NG; Schoenfelder, A; Schoepp, DD; Wermuth, CG; Wright, RA | 1 |
| Ballerini, P; Battaglia, G; Caciagli, F; Ciccarelli, R; Di Iorio, P; Giuliani, P; Nicoletti, F; Poli, A | 1 |
| Berrino, L; D'Amico, M; de Novellis, V; Pizzirusso, A; Rossi, F | 1 |
| Bruno, V; Marinozzi, M; Nicoletti, F; Pellicciari, R; Thomsen, C | 1 |
| Dichter, MA; Fitzsimonds, RM | 1 |
| Alexander, SP; Kendall, DA; Neil, KE | 1 |
| Kaneko, A; Sasaki, T | 1 |
| Barrios, M; Liljequist, S | 1 |
| Leonardi, P; Lombardi, G; Moroni, F | 1 |
| Mennerick, S; Que, J; Zorumski, CF | 1 |
| Felipo, V; Grisolía, S; Hermenegildo, C; Llsansola, M; Miñana, MD; Montoliu, C | 1 |
| Koenig, ML; Meyerhoff, JL; Yourick, DL | 1 |
| Arnolda, LF; Chalmers, JP; Llewellyn-Smith, IJ; Minson, JB; Pilowsky, PM | 1 |
| Fu, WM; Liou, HC; Yang, RS | 1 |
| Chisamore, B; Dow, K; Solc, M | 1 |
| Attwell, D; Sarantis, M; Takahashi, M | 1 |
| Fibiger, HC; Taber, MT | 1 |
| Haak, LL; Heller, HC; van den Pol, AN | 1 |
| Fragoso, G; López-Colomé, AM; Ortega, A; Trueba, E | 1 |
| Acher, F; Azerad, R; Bockaert, J; Gharbi-Benarous, J; Girault, JP; Larue, V; Pin, JP; Todeschi, N | 1 |
| Bon, C; Galvan, M; Holzwarth, JA; Pruss, RM; Stephan, D | 1 |
| Abe, I; Fujishima, M; Kagiyama, S; Onaka, U; Tsuchihashi, T | 1 |
| Dow, KE; Wang, W | 1 |
| Fergus, A; Lee, KS | 1 |
| Bossu, JL; Gähwiler, BH; Gerber, U; Guérineau, NC | 1 |
| Albasanz, JL; Martín, M; Ros, M | 1 |
| Neale, JH; Pshenichkin, S; Sullivan, SE; Surin, A; Wroblewska, B; Wroblewski, JT | 1 |
| Deng, A; Growdon, JH; Nitsch, RM; Wurtman, RJ | 1 |
| Blasi, F; Guerrini, L; Kistler, B; Molteni, A; Wirth, T | 1 |
| Attucci, S; Cozzi, A; Luneia, R; Marinozzi, M; Moroni, F; Pellicciari, R; Peruginelli, F | 1 |
| Mifflin, SW; Zhang, J | 1 |
| Bräuner-Osborne, H; Curry, K; Madsen, U; Mikiciuk-Olasik, E | 1 |
| Blue, ME; Brennan, EM; Johnston, MV; Martin, LJ | 1 |
| Nicholls, DG | 1 |
| Neher, E; Schneggenburger, R; von Gersdorff, H; Weis, S | 1 |
| Dudel, J; Schramm, M | 1 |
| Bear, MF; Huber, KM; Sawtell, NB | 1 |
| Bezzi, P; Carmignoto, G; Pasti, L; Pozzan, T; Rizzini, BL; Rossi, D; Vesce, S; Volterra, A | 1 |
| Kennedy, RT; Lada, MW; Vickroy, TW | 1 |
| Beart, PM; Jones, NM; Lawrence, AJ | 1 |
| Cardoso, LF; Martini, LH; Ramírez, G; Souza, DO; Tasca, CI | 1 |
| Baird, DH; Console-Bram, LM; Fitzpatrick-McElligott, SG; McElligott, JG | 1 |
| Acher, F; Azerad, R; Brabet, I; Pin, JP; Tellier, F | 1 |
| Cai, Z; Rhodes, PG | 1 |
| Kitai, ST; Plenz, D | 1 |
| Ellis, EF; Rzigalinski, BA; Weber, JT; Willoughby, KA | 1 |
| González, MP; Herrero, MT; Oset-Gasque, MJ; Vicente, S | 1 |
| Carfì, M; Cozzi, A; Leonardi, P; Lombardi, G; Moroni, F; Pellicciari, R; Sourtcheva, S | 1 |
| Becker, A; Hoellt, V; Schroeder, H | 1 |
| Schwarzer, C; Sperk, G | 1 |
| López, T; López-Colomé, AM; Ortega, A | 1 |
| Cox, CL; Sherman, SM; Zhou, Q | 1 |
| Sattler, R; Spetzler, RF; Tymianski, M; Zabramski, JM | 1 |
| Näsström, J; Sequeira, S | 1 |
| Murali, SG; Sun, D | 1 |
| Boddeke, HW; Hiltscher, R; Laurie, DJ; Seuwen, K; Sommer, B | 1 |
| Eriksson, PS; Hansson, E; Rönnbäck, L; Thorlin, T | 1 |
| Jevtovic-Todorovic, V; Mennerick, S; Olney, JW; Shen, W; Todorovic, SM; Zorumski, CF | 1 |
| Banno, T; Kohno, K | 1 |
| Bortolotto, ZA; Collingridge, GL; Doherty, AJ; Fitzjohn, SM; Kingston, AE; Lodge, D; Ornstein, PL; Palmer, MJ; Schoepp, DD | 1 |
| Kelly, A; Lynch, MA | 1 |
| Sontheimer, H; Ye, ZC | 1 |
| Boudaba, C; Schrader, LA; Tasker, JG | 1 |
| Bockaert, J; Fagni, L; Guiraud, MJ; Lafon-Cazal, M; Lerner-Natoli, M; Mary, S; Pin, JP; Shigemoto, R | 1 |
| Irić-Cupić, V; Janković, SM; Matović, M; Milovanović, D | 1 |
| Bhatnagar, T; Chitravanshi, VC; Sapru, HN | 1 |
| Masgrau, R; Picatoste, F; Sarri, E; Servitja, JM | 1 |
| Berthele, A; Biber, K; Boddeke, HW; Gebicke-Härter, PJ; Laurie, DJ; Sommer, B; Tölle, TR; van Calker, D | 1 |
| Kato, BM; Rubel, EW | 1 |
| Linden, R; Martins, RA; Rocha, M | 1 |
| Kelly, A; Lynch, MA; Maguire, C; McGahon, B | 1 |
| Bernardi, G; Calabresi, P; Centonze, D; Gubellini, P; Marfia, GA | 1 |
| Aggleton, JP; Bashir, ZI; Bortolotto, ZA; Brown, MW; Cho, K; Collingridge, GL; Conquet, F; McCaffery, B | 1 |
| Dammerman, RS; Flint, AC; Kriegstein, AR | 1 |
| Hanania, T; Johnson, KM | 1 |
| Blanc, EM; Guiramand, J; Jallageas, M; Recasens, M | 1 |
| Endo, S; Hirashima, Y; Kurimoto, M; Muraguchi, A; Nagata, T; Nogami, K; Ohtani, O; Saitoh, M; Takaku, A | 1 |
| Bardgett, ME; Henry, JD | 1 |
| Herrero, I; Manahan-Vaughan, D; Reymann, KG; Sánchez-Prieto, J | 1 |
| Horrobin, DF; Lynch, MA; Martin, DS; McGahon, BM | 1 |
| Ballanyi, K; Kulik, A; Metzger, F; Sendtner, M | 1 |
| Ellis, EF; Moore, SF; Rzigalinski, BA; Weber, JT; Willoughby, KA | 1 |
| Crawford, JH; Heavens, R; Martin, DJ; Pollock, J; Scott, RH; Seabrook, GR; Wainwright, A | 1 |
| Connaughton, VP; Nelson, R | 1 |
| Alford, S; Schwartz, NE | 1 |
| Adamchik, Y; Baskys, A | 1 |
| Cox, CL; Sherman, SM | 1 |
| Zilberter, Y | 1 |
| Bennett, HJ; Semba, K; White, TD | 1 |
| Ellis, EF; Floyd, CL; Rzigalinski, BA; Sitterding, HA; Weber, JT; Willoughby, KA | 1 |
| Bear, M; Blakemore, C; Hannan, AJ; Huber, KM; Katsnelson, A; Kim, D; Kind, PC; Roder, J; Shin, HS; Vitalis, T | 1 |
| Inoue, N; Nakayama, T; Soga, TM | 1 |
| de Almeida, OM; de Mello, FG; de Mello, MC; Gardino, PF; Kubrusly, RC; Loureiro-Dos-Santos, NE; Reis, RA | 1 |
| Hirai, H | 1 |
| Chamberlain, M; Johnson, MP; Kelly, G | 1 |
| Hirose, K; Iino, M; Kakizawa, S; Okubo, Y | 1 |
| Crepel, F; Daniel, H; Levenes, C | 1 |
| Ransom, BR; Sontheimer, H; Ye, ZC | 1 |
| Abe, I; Fujishima, M; Kagiyama, S; Matsumura, K; Phillips, MI; Tsuchihashi, T | 1 |
| Akaike, N; Doi, A; Ishibashi, H; Jinno, S; Kosaka, T | 1 |
| Chan, JY; Lo, WC; Tseng, CJ; Tung, CS | 1 |
| Woody, CD | 1 |
| Jankovic, SM; Milovanovic, DR | 1 |
| Hong, YM; Jun, K; Kim, DY; Kim, YI; Lee, S; Park, D; Shin, HS | 1 |
| Fiumana, E; Jaggar, JH; Leffler, CW; Parfenova, H | 1 |
| Boldyrev, A; Bulygina, E; Gerasimova, O | 1 |
| Alexander, JS; Chi, A; Elrod, JW; Hines, I; Houghton, J; Jackson, TH; Jawahar, A; Long, A; Minagar, A; Nanda, A; Sharp, CD; Warren, A | 1 |
| Barbanel, G; Kamenka, JM; Laplanche, L; Michaud, M | 1 |
| Carmignoto, G; Fellin, T; Gobbo, S; Pozzan, T; Sebelin, A; Zonta, M | 1 |
| Lu, Y; Rubel, EW | 1 |
| Andrianov, GN; Demêmes, D; Puyal, J; Raymond, J; Ryzhova, IV; Ventéo, S | 1 |
| Calixto, JB; Gadotti, VM; Paszcuk, AF; Rodrigues, AL; Santos, AR; Tibola, D | 1 |
| Andrianov, GN; Nozdrachev, AD; Ryzhova, IV | 1 |
| Grau, Y; Hamasaka, Y; Helfrich-Förster, C; Nässel, DR; Parmentier, ML; Rieger, D | 1 |
| Jakovljevic, M; Jankovic, SM; Jankovic, SV; Milovanovic, D; Stojadinovic, D | 1 |
| Beltramo, M; Brusa, R; Lozza, G; Mancini, I; Petrò, R; Reggiani, A; Scandroglio, P | 1 |
| Dong, LP; Han, M; Wang, TY; Xu, LX; Yuan, F | 1 |
| Bartoletti, TM; Thoreson, WB | 1 |
3 review(s) available for glutamic acid and 1-amino-1,3-dicarboxycyclopentane
| Article | Year |
|---|---|
Metabotropic glutamate receptors: novel targets for drug development.
Topics: Animals; Cloning, Molecular; Drug Design; Humans; Receptors, Metabotropic Glutamate | 1995 |
Ligands for glutamate receptors: design and therapeutic prospects.
Topics: Animals; Drug Design; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Ligands; N-Methylaspartate; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Synapses | 2000 |
Glutamate-induced calcium signaling in astrocytes.
Topics: Animals; Animals, Newborn; Astrocytes; Calcium; Cell Communication; Cell Compartmentation; Cells, Cultured; Cycloleucine; Glutamic Acid; Hippocampus; Humans; Inositol 1,4,5-Trisphosphate; Models, Neurological; Nerve Tissue Proteins; Rats; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Second Messenger Systems; Videodisc Recording | 1994 |
210 other study(ies) available for glutamic acid and 1-amino-1,3-dicarboxycyclopentane
| Article | Year |
|---|---|
Cloning, distribution and functional expression of the human mGlu6 metabotropic glutamate receptor.
Topics: Amino Acid Sequence; Animals; Cell Line; CHO Cells; Cloning, Molecular; Colforsin; Cricetinae; Cyclic AMP; DNA; Humans; Molecular Sequence Data; Polymerase Chain Reaction; Rats; Receptors, Metabotropic Glutamate; Retina; RNA, Messenger; Tissue Distribution | 1997 |
Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells.
Topics: Amino Acid Sequence; Amino Acid Transport System X-AG; Animals; ATP-Binding Cassette Transporters; Cell Line; Cloning, Molecular; Colforsin; Consensus Sequence; Cyclic AMP; DNA, Complementary; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Mice; Molecular Sequence Data; Rats; Receptors, Metabotropic Glutamate; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Transfection | 1998 |
Synthesis and biology of the conformationally restricted ACPD analogue, 2-aminobicyclo[2.1.1]hexane-2,5-dicarboxylic acid-I, a potent mGluR agonist.
Topics: Animals; Bridged Bicyclo Compounds; Calcium; Cells, Cultured; Cerebellum; CHO Cells; Cricetinae; Cyclic AMP; Cycloleucine; Dicarboxylic Acids; Excitatory Amino Acid Agonists; Glutamic Acid; Inositol Phosphates; Kidney; Ligands; Models, Molecular; Molecular Conformation; Norbornanes; Rats; Receptors, Metabotropic Glutamate; Stereoisomerism | 1998 |
Agonist selectivity of mGluR1 and mGluR2 metabotropic receptors: a different environment but similar recognition of an extended glutamate conformation.
Topics: Animals; Binding Sites; Cell Line; CHO Cells; Cricetinae; Glutamates; Ligands; Models, Molecular; Molecular Conformation; Receptors, Metabotropic Glutamate; Structure-Activity Relationship | 1999 |
1-amino-APDC, a partial agonist of group II metabotropic glutamate receptors with neuroprotective properties.
Topics: Animals; Cell Death; CHO Cells; Cricetinae; Excitatory Amino Acid Agonists; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Proline; Receptors, Metabotropic Glutamate | 1999 |
Pharmacophore models of group I and group II metabotropic glutamate receptor agonists. Analysis of conformational, steric, and topological parameters affecting potency and selectivity.
Topics: Excitatory Amino Acid Agonists; Ligands; Molecular Conformation; Receptors, Metabotropic Glutamate; Structure-Activity Relationship | 1999 |
[3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells.
Topics: Amino Acids; Animals; Binding, Competitive; Calcium; Cell Membrane; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Kinetics; Radioligand Assay; Receptors, Metabotropic Glutamate; Recombinant Proteins; Transfection; Tritium; Xanthenes | 1999 |
Characterization of [(3)H]Quisqualate binding to recombinant rat metabotropic glutamate 1a and 5a receptors and to rat and human brain sections.
Topics: Animals; Binding, Competitive; Brain; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glycine; Humans; Imidazoles; Indans; Intracellular Fluid; Kainic Acid; Male; Organ Specificity; Quinazolines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Recombinant Proteins; Spinal Cord; Transfection | 2000 |
Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes.
Topics: Amino Acids; Binding, Competitive; Cell Membrane; Excitatory Amino Acid Antagonists; Humans; Kinetics; Radioligand Assay; Receptors, Metabotropic Glutamate; Recombinant Proteins; Substrate Specificity; Tritium; Xanthenes | 2000 |
(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-methylcyclopropyl) glycine is a potent and selective metabotropic group 2 receptor agonist with anxiolytic properties.
Topics: Animals; Anti-Anxiety Agents; Bridged Bicyclo Compounds; Cell Line; Cyclopropanes; Glycine; Ligands; Models, Molecular; Rats; Receptors, Metabotropic Glutamate; Reflex, Startle; Stereoisomerism | 2002 |
[3H]R214127: a novel high-affinity radioligand for the mGlu1 receptor reveals a common binding site shared by multiple allosteric antagonists.
Topics: Adamantane; Allosteric Regulation; Animals; Binding Sites; Binding, Competitive; Brain; Cell Line; Cell Membrane; CHO Cells; Chromones; Cricetinae; Humans; Naphthalenes; Pyrans; Quinolines; Quinoxalines; Quisqualic Acid; Radioligand Assay; Rats; Receptors, Metabotropic Glutamate; Transfection; Tritium | 2003 |
[Effect of trans-ACPD, a specific agonist of glutamate interacting with metabotropic receptors, on synaptic transmission in the rat hippocampus].
Topics: Animals; Cycloleucine; Evoked Potentials; Glutamates; Glutamic Acid; Hippocampus; Membrane Potentials; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Synapses; Synaptic Transmission | 1992 |
Activation of metabotropic glutamate receptors in the hippocampus increases cyclic AMP accumulation.
Topics: Alanine; Animals; Cyclic AMP; Cycloleucine; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Male; Neurotoxins; Osmolar Concentration; Rats; Rats, Inbred Strains; Receptors, Glutamate; Receptors, Neurotransmitter | 1992 |
Characterization of a metabotropic glutamate receptor: direct negative coupling to adenylyl cyclase and involvement of a pertussis toxin-sensitive G protein.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Alanine; Alkaloids; Animals; Cell Membrane; Cells, Cultured; Colforsin; Corpus Striatum; Cycloleucine; Glutamates; Glutamic Acid; GTP-Binding Proteins; In Vitro Techniques; Mice; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Protein Kinase C; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter; Signal Transduction; Staurosporine; Virulence Factors, Bordetella | 1992 |
Activation of quisqualate metabotropic receptors reduces glutamate and GABA-mediated synaptic potentials in the rat striatum.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Corpus Striatum; Cycloleucine; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; In Vitro Techniques; Neurotoxins; Quinoxalines; Rats; Receptors, AMPA; Receptors, Neurotransmitter; Synapses | 1992 |
Trans-ACPD and L-APB presynaptically inhibit excitatory glutamatergic transmission in the basolateral amygdala (BLA).
Topics: Aminobutyrates; Amygdala; Animals; Cycloleucine; Electrodes; Evoked Potentials; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Membrane Potentials; Rats; Rats, Sprague-Dawley; Synaptic Transmission | 1992 |
Metabotropic receptor mediated afterdepolarization in neocortical neurons.
Topics: Action Potentials; Animals; Cerebral Cortex; Cycloleucine; Glutamates; Glutamic Acid; In Vitro Techniques; Microelectrodes; Neuromuscular Depolarizing Agents; Neurons; Quisqualic Acid; Rats; Receptors, Glutamate | 1992 |
Positive feedback of glutamate exocytosis by metabotropic presynaptic receptor stimulation.
Topics: 4-Aminopyridine; Animals; Arachidonic Acid; Calcium; Cycloleucine; Dose-Response Relationship, Drug; Exocytosis; Feedback; Glutamates; Glutamic Acid; Male; Neurotoxins; Rats; Rats, Wistar; Receptors, Glutamate; Synaptosomes | 1992 |
Trans-ACPD-induced phosphoinositide hydrolysis and modulation of hippocampal pyramidal cell excitability do not undergo parallel developmental regulation.
Topics: Action Potentials; Animals; Cycloleucine; Female; Glutamates; Glutamic Acid; Hippocampus; Hydrolysis; In Vitro Techniques; Male; Phosphatidylinositols; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 1992 |
Metabotropic glutamate receptors potentiate ionotropic glutamate responses in the rat dorsal horn.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cycloleucine; Drug Synergism; Glutamates; Glutamic Acid; Ibotenic Acid; Ion Channel Gating; Kainic Acid; Myocardial Contraction; N-Methylaspartate; Neurons; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; Spinal Cord; Synapses; Synaptic Transmission | 1992 |
4C3HPG (RS-4-carboxy-3-hydroxyphenylglycine), a weak agonist at metabotropic glutamate receptors, occludes the action of trans-ACPD in hippocampus.
Topics: Animals; Cycloleucine; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hippocampus; In Vitro Techniques; Ion Channels; Rats; Receptors, Glutamate | 1992 |
Glutamate mediates a slow synaptic response in hippocampal slice cultures.
Topics: Animals; Cycloleucine; Electric Stimulation; Electrophysiology; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Potassium; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Amino Acid; Receptors, Cell Surface; Synapses | 1991 |
Autoradiographic imaging of phosphoinositide turnover in the brain.
Topics: Alanine; Animals; Autoradiography; Brain; Carbachol; Cerebellum; Cycloleucine; Cytidine; Cytidine Diphosphate Diglycerides; Glutamates; Glutamic Acid; Hippocampus; Neomycin; Phosphatidylinositols; Pirenzepine; Purkinje Cells; Rats; Receptors, Muscarinic; Tissue Distribution | 1990 |
Arachidonic acid released from striatal neurons by joint stimulation of ionotropic and metabotropic quisqualate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Arachidonic Acid; Arachidonic Acids; Aspartic Acid; Cells, Cultured; Corpus Striatum; Cycloleucine; Electrophysiology; Glutamates; Glutamic Acid; Ibotenic Acid; N-Methylaspartate; Neurons; Oxadiazoles; Quisqualic Acid; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synapses | 1990 |
Developmental change from inhibition to facilitation in the presynaptic control of glutamate exocytosis by metabotropic glutamate receptors.
Topics: Animals; Calcium; Cerebral Cortex; Cycloleucine; Excitatory Amino Acid Agonists; Exocytosis; Glutamic Acid; In Vitro Techniques; Membrane Potentials; Nerve Endings; Neurotoxins; Rats; Receptors, Metabotropic Glutamate; Receptors, Presynaptic; Synaptic Membranes; Synaptosomes | 1995 |
Brief calcium transients evoked by glutamate receptor agonists in rat dorsal horn neurons: fast kinetics and mechanisms.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Cells, Cultured; Cycloleucine; Female; Glutamates; Glutamic Acid; Ion Channel Gating; Kainic Acid; Kinetics; Lanthanum; N-Methylaspartate; Neurons; Neurotoxins; Photometry; Potassium; Pregnancy; Presynaptic Terminals; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1993 |
Membrane currents evoked by excitatory amino acid agonists in ON bipolar cells of the mudpuppy retina.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Aminobutyrates; Animals; Cadmium; Cell Membrane; Cobalt; Cycloleucine; Electrophysiology; Glutamates; Glutamic Acid; Ion Channels; Kainic Acid; Membrane Potentials; N-Methylaspartate; Necturus maculosus; Neurotransmitter Agents; Receptors, Amino Acid; Retina | 1993 |
Glutamate-evoked release of arachidonic acid from mouse brain astrocytes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Arachidonic Acid; Astrocytes; Brain; Cells, Cultured; Cerebellum; Cerebral Cortex; Corpus Striatum; Cycloleucine; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Inositol Phosphates; Kainic Acid; Kinetics; Mice; N-Methylaspartate; Neurotoxins; Organ Specificity; Quisqualic Acid; Receptors, Glutamate; Time Factors; Tritium | 1994 |
Metabotropic glutamate receptor modulation of cAMP accumulation in the neonatal rat hippocampus.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Deaminase; Animals; Animals, Newborn; Colforsin; Cyclic AMP; Cycloleucine; Female; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Male; Neurotoxins; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 1993 |
The effect of experimental ischaemia and excitatory amino acid agonists on the GABA and serotonin immunoreactivities in the rabbit retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Cycloleucine; Dextromethorphan; Eye Proteins; gamma-Aminobutyric Acid; Glucose; Glutamates; Glutamic Acid; Intraocular Pressure; Ischemia; Kainic Acid; Kynurenic Acid; Memantine; N-Methylaspartate; Oxygen; Potassium Cyanide; Quinoxalines; Rabbits; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Retina; Retinal Vessels; Serotonin | 1994 |
Glutamate receptor-driven activation of transcription factors in primary neuronal cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Astrocytes; Base Sequence; Binding Sites; Cell Nucleus; Cell Survival; Cells, Cultured; Cycloleucine; Embryo, Mammalian; Gene Expression; Glutamates; Glutamic Acid; Kainic Acid; Kinetics; Mice; Molecular Sequence Data; N-Methylaspartate; Neurons; Proto-Oncogene Proteins; Proto-Oncogenes; Quisqualic Acid; Rats; Receptors, Glutamate; Transcription Factors | 1994 |
Competitive antagonism by phenylglycine derivatives at type I metabotropic glutamate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Benzoates; Binding, Competitive; Calcium; Cells, Cultured; CHO Cells; Cricetinae; Cycloleucine; Cytidine Diphosphate Diglycerides; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Glycine; Ibotenic Acid; Kainic Acid; Neurons; Neurotoxins; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phosphoric Diester Hydrolases; Quisqualic Acid; Receptors, Metabotropic Glutamate; Recombinant Fusion Proteins; Signal Transduction | 1994 |
Metabotropic glutamate receptor in C6BU-1 glioma cell has NMDA receptor-ion channel complex-like properties and interacts with serotonin2 receptor-stimulated signal transduction.
Topics: 2-Amino-5-phosphonovalerate; Animals; Aspartic Acid; Calcium; Cell Line; Cycloleucine; Dizocilpine Maleate; Glioma; Glutamic Acid; Inositol 1,4,5-Trisphosphate; Ion Channels; Kainic Acid; Kinetics; Magnesium Chloride; N-Methylaspartate; Neurotoxins; Pyrrolidinones; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Signal Transduction; Tumor Cells, Cultured | 1994 |
Potentiation of synaptic transmission in the rat hippocampal slice by exogenous L-glutamate and selective L-glutamate receptor subtype agonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Evoked Potentials; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Hippocampus; In Vitro Techniques; Iontophoresis; N-Methylaspartate; Nerve Fibers; Neurotoxins; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Synapses; Synaptic Transmission | 1994 |
Modulation of neuropeptide FF release from rat spinal cord slices by glutamate. Involvement of NMDA receptors.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Dizocilpine Maleate; Glutamic Acid; In Vitro Techniques; Iodine Radioisotopes; Male; Membranes; N-Methylaspartate; Neuropeptides; Neurotoxins; Oligopeptides; Radioimmunoassay; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 1994 |
Glutamate-induced swelling of single astroglial cells in primary culture.
Topics: Aminobutyrates; Animals; Animals, Newborn; Astrocytes; Calcium; Cell Size; Cells, Cultured; Cerebral Cortex; Cycloleucine; Extracellular Space; Glutamic Acid; GTP-Binding Proteins; Ion Channels; Neurotoxins; Pertussis Toxin; Potassium Channels; Rats; Receptors, Glutamate; Spectrometry, Fluorescence; Virulence Factors, Bordetella | 1994 |
A glutamate-activated chloride current in cone-driven ON bipolar cells of the white perch retina.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Chloride Channels; Chlorides; Cycloleucine; Dendrites; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Membrane Potentials; N-Methylaspartate; Neurotoxins; Patch-Clamp Techniques; Perches; Picrotoxin; Quinoxalines; Quisqualic Acid; Receptors, Metabotropic Glutamate; Retina; Retinal Cone Photoreceptor Cells; Strychnine | 1995 |
AMPA receptor activation regulates the glutamate metabotropic receptor stimulated phosphatidylinositol turnover in human cerebral cortex slices.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Adolescent; Adult; Aged; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Calcimycin; Cerebral Cortex; Child; Cycloleucine; Dizocilpine Maleate; Female; Glutamic Acid; Humans; Male; Middle Aged; N-Methylaspartate; Phosphatidylinositols; Quisqualic Acid; Receptors, AMPA; Receptors, Metabotropic Glutamate; Signal Transduction; Tetrodotoxin | 1995 |
GFAP-positive hippocampal astrocytes in situ respond to glutamatergic neuroligands with increases in [Ca2+]i.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Calcium; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Rats | 1995 |
Intracellular acidification and Ca2+ transients in cultured rat cerebellar astrocytes evoked by glutamate agonists and noradrenaline.
Topics: Animals; Animals, Newborn; Aspartic Acid; Astrocytes; Calcium; Cells, Cultured; Cerebellum; Cycloleucine; Excitatory Amino Acid Agonists; Fluoresceins; Fluorescent Dyes; Fura-2; Glutamic Acid; Hydrogen-Ion Concentration; Kainic Acid; Neurotoxins; Norepinephrine; Rats; Receptors, Metabotropic Glutamate | 1995 |
Activation of K+ channels by stimulation of metabotropic glutamate receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cycloleucine; Glutamic Acid; Hippocampus; In Vitro Techniques; Neurons; Potassium Channels; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Stimulation, Chemical; Valine | 1995 |
Metabotropic glutamate receptor agonists inhibit endogenous glutamate release from rat striatal synaptosomes.
Topics: 4-Aminopyridine; Aminobutyrates; Animals; Corpus Striatum; Cycloleucine; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Rats; Receptors, Metabotropic Glutamate; Synaptosomes | 1995 |
Amyloid precursor protein processing is stimulated by metabotropic glutamate receptors.
Topics: Alanine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cell Line; Chelating Agents; Cycloleucine; Embryo, Mammalian; Fetus; Glioma; Glutamic Acid; Hippocampus; Humans; Indoles; Kidney; Kinetics; Maleimides; N-Methylaspartate; Neuroblastoma; Neurons; Neurotoxins; PC12 Cells; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Protein Kinase C; Protein Processing, Post-Translational; Pyrimidines; Quinacrine; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1995 |
Activation of metabotropic glutamate receptors produces reciprocal regulation of ionotropic glutamate and GABA responses in the nucleus of the tractus solitarius of the rat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Electrophysiology; Female; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Ibotenic Acid; Male; Medulla Oblongata; Muscimol; Neurons; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Synapses | 1993 |
(R,S)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors mediate a calcium-dependent inhibition of the metabotropic glutamate receptor-stimulated formation of inositol 1,4,5-trisphosphate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cycloleucine; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Inositol 1,4,5-Trisphosphate; N-Methylaspartate; Protein Kinases; Rats; Receptors, AMPA; Receptors, Glutamate | 1993 |
Quisqualate resolves two distinct metabotropic [3H]glutamate binding sites.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Binding, Competitive; Brain Chemistry; Corpus Striatum; Cycloleucine; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Male; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid | 1993 |
N-acetylaspartylglutamate inhibits forskolin-stimulated cyclic AMP levels via a metabotropic glutamate receptor in cultured cerebellar granule cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Cerebellum; Colforsin; Cyclic AMP; Cycloleucine; Dipeptides; Glutamates; Glutamic Acid; Granulocytes; Inositol Phosphates; Receptors, Glutamate | 1993 |
Excitatory amino acid-induced slow biphasic responses of free intracellular calcium in human neuroblastoma cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Calcium; Cycloleucine; Glutamates; Glutamic Acid; Humans; Ibotenic Acid; Kainic Acid; N-Methylaspartate; Receptors, Glutamate; Tumor Cells, Cultured | 1993 |
Toward an understanding of the role of glutamate in experimental parkinsonism: agonist-sensitive sites in the basal ganglia.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Basal Ganglia; Cycloleucine; Electromyography; Glutamates; Glutamic Acid; Kainic Acid; Male; Muscles; N-Methylaspartate; Parkinson Disease; Rats; Receptors, Glutamate | 1993 |
Effects of bromohomoibotenate on metabotropic glutamate receptors.
Topics: Aminobutyrates; Animals; Binding, Competitive; Cell Line; Cerebral Cortex; Cricetinae; Cyclic AMP; Cycloleucine; Dose-Response Relationship, Drug; Glutamic Acid; Hippocampus; Hydrolysis; Ibotenic Acid; Kidney; Membranes; Phosphatidylinositols; Quinoxalines; Receptors, AMPA; Receptors, Metabotropic Glutamate; Stereoisomerism | 1994 |
Molecular, functional, and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants: comparison with mGluR1.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Brain; Cell Line; Cyclic AMP; Cycloleucine; DNA Primers; Female; Gene Library; Genetic Variation; Glutamic Acid; Ibotenic Acid; In Situ Hybridization; Kidney; Molecular Sequence Data; Neurotoxins; Oocytes; Polymerase Chain Reaction; Prosencephalon; Quisqualic Acid; Rats; Receptors, Metabotropic Glutamate; Recombinant Proteins; Restriction Mapping; RNA, Messenger; Spleen; Swine; Transfection; Xenopus | 1995 |
Activation of a metabotropic glutamate receptor increases intracellular calcium concentrations in neurons of the avian cochlear nucleus.
Topics: Animals; Calcium; Chick Embryo; Cochlear Nucleus; Cycloleucine; Glutamic Acid; In Vitro Techniques; Intracellular Membranes; Neurons; Osmolar Concentration; Quisqualic Acid; Receptors, Metabotropic Glutamate | 1995 |
Pharmacological dissociation of glutamatergic metabotropic signal transduction pathways in cortical astrocytes.
Topics: Animals; Astrocytes; Benzoates; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Cycloleucine; Dicarboxylic Acids; Glutamic Acid; Glycine; Isoproterenol; Neuroglia; Neurotoxins; Phosphatidylinositols; Pyrrolidines; Rats; Receptors, Metabotropic Glutamate; Signal Transduction | 1994 |
A study of the synergism between metabotropic glutamate receptor activation and arachidonic acid in the rat hippocampus.
Topics: Animals; Arachidonic Acid; Cyclic AMP; Cycloleucine; Drug Synergism; Glutamic Acid; Hippocampus; Male; Phosphatidylinositols; Protein Kinase C; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synaptosomes | 1994 |
Glutamate receptors on type I vestibular hair cells of guinea-pig.
Topics: Animals; Calcium; Cell Separation; Cycloleucine; Glutamates; Glutamic Acid; Guinea Pigs; Hair Cells, Auditory; Intracellular Membranes; Receptors, AMPA; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1993 |
Potentiating and depressant effects of metabotropic glutamate receptor agonists on high-voltage-activated calcium currents in cultured retinal ganglion neurons from postnatal mice.
Topics: Alanine; Aminobutyrates; Animals; Calcium; Calcium Channels; Cells, Cultured; Cycloleucine; Glutamates; Glutamic Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Intracellular Fluid; Mice; omega-Conotoxin GVIA; Organophosphorus Compounds; Peptides; Quisqualic Acid; Receptors, Metabotropic Glutamate; Retinal Ganglion Cells | 1994 |
(1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid attenuates N-methyl-D-aspartate-induced neuronal cell death in cortical cultures via a reduction in delayed Ca2+ accumulation.
Topics: Animals; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Cycloleucine; Fetus; Glutamates; Glutamic Acid; Kinetics; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Neurotoxins; Pertussis Toxin; Phosphatidylinositols; Rats; Time Factors; Virulence Factors, Bordetella | 1993 |
An ibotenate-selective metabotropic glutamate receptor mediates protein phosphorylation in cultured hippocampal pyramidal neurons.
Topics: Animals; Calcium; Cycloleucine; Diglycerides; Embryo, Mammalian; Glutamates; Glutamic Acid; Hippocampus; Ibotenic Acid; Inositol; Inositol Phosphates; Kainic Acid; Myristic Acid; Myristic Acids; N-Methylaspartate; Nerve Tissue Proteins; Neurotoxins; Pertussis Toxin; Phosphatidylcholines; Phosphatidylinositols; Phosphoproteins; Phosphorylation; Protein Kinase C; Pyramidal Cells; Quisqualic Acid; Rats; Receptors, Glutamate; Stearic Acids; Virulence Factors, Bordetella | 1994 |
Activation of glutamate receptors stimulates the formation of nitrite in synaptosomes from rat cerebellum.
Topics: Animals; Cerebellum; Cycloleucine; Glutamates; Glutamic Acid; Male; N-Methylaspartate; Nitrites; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Synaptosomes | 1994 |
Glutamate modulates [Ca2+]i and gonadotropin-releasing hormone secretion in immortalized hypothalamic GT1-7 neurons.
Topics: Animals; Calcium; Cells, Cultured; Cycloleucine; Excitatory Amino Acid Antagonists; Fura-2; Glutamates; Glutamic Acid; Gonadotropin-Releasing Hormone; Hypothalamus; Inositol Phosphates; Mice; Mice, Transgenic; Neurons; Neurotoxins; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Spectrometry, Fluorescence | 1994 |
Metabotropic glutamate response in acutely dissociated hippocampal CA1 pyramidal neurones of the rat.
Topics: Animals; Calcium; Cycloleucine; Dose-Response Relationship, Drug; Electrophysiology; Glutamates; Glutamic Acid; GTP-Binding Proteins; Hippocampus; Intracellular Membranes; Osmolar Concentration; Potassium Channels; Pyramidal Cells; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1994 |
Distribution and ontogeny of 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid-sensitive and quisqualate-insensitive [3H]glutamate binding sites in the rat brain.
Topics: Animals; Anions; Brain; Bromides; Calcium; Cell Membrane; Chlorides; Cycloleucine; Female; Glutamates; Glutamic Acid; Hypothalamus; Male; Prosencephalon; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Tritium | 1994 |
Metabotropic glutamate receptor activation induces astroglial swelling.
Topics: Animals; Animals, Newborn; Astrocytes; Calcium; Cell Size; Cells, Cultured; Cerebral Cortex; Cycloleucine; Glutamates; Glutamic Acid; Ibotenic Acid; Rats; Receptors, Metabotropic Glutamate | 1994 |
The effects of L-glutamate and trans-(+-)-1-amino-1,3-cyclopentanedicarboxylate on phosphoinositide hydrolysis can be pharmacologically differentiated.
Topics: Alanine; Animals; Animals, Newborn; Aspartic Acid; Benzoates; Brain; Cerebellum; Cycloleucine; Glutamic Acid; Glycine; Hippocampus; Hydrolysis; Ibotenic Acid; Inositol Phosphates; Kinetics; Neurotoxins; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Stereoisomerism | 1994 |
Glutamate exocytosis and MARCKS phosphorylation are enhanced by a metabotropic glutamate receptor coupled to a protein kinase C synergistically activated by diacylglycerol and arachidonic acid.
Topics: Animals; Arachidonic Acid; Calcium; Cerebral Cortex; Cycloleucine; Cytosol; Diglycerides; Drug Synergism; Enzyme Activation; Exocytosis; Glutamic Acid; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Myristoylated Alanine-Rich C Kinase Substrate; Neurotoxins; Phosphorylation; Protein Kinase C; Proteins; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synaptosomes | 1994 |
L-glutamate uptake inhibitors may stimulate phosphoinositide hydrolysis in baby hamster kidney cells expressing mGluR1a via heteroexchange with L-glutamate without direct activation of mGluR1a.
Topics: Alanine Transaminase; Animals; Asparagine; Aspartic Acid; Cell Line; Cell Membrane; Cricetinae; Cycloleucine; Cysteine; Dicarboxylic Acids; Excitatory Amino Acid Antagonists; Glutamate Decarboxylase; Glutamic Acid; Hydrolysis; Kidney; N-Methylaspartate; Phosphatidylinositols; Pyrrolidines; Receptors, Metabotropic Glutamate | 1994 |
The metabotropic glutamate receptor types 2/3 inhibit L-type calcium channels via a pertussis toxin-sensitive G-protein in cultured cerebellar granule cells.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cerebellum; Cyclic AMP; Cycloleucine; Dihydropyridines; Glutamic Acid; GTP-Binding Proteins; Mice; Neurotoxins; Nifedipine; Pertussis Toxin; Protein Kinases; Receptors, Metabotropic Glutamate; Second Messenger Systems; Up-Regulation; Virulence Factors, Bordetella | 1994 |
Metabotropic glutamate receptors are involved in the control of breathing at the medulla oblongata level of anaesthetized rats.
Topics: Alanine; Anesthesia; Animals; Blood Pressure; Cycloleucine; Glutamic Acid; Injections; Male; Medulla Oblongata; Neurotoxins; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Respiratory Mechanics; Solitary Nucleus | 1994 |
Role of arachidonic acid in the facilitation of glutamate release from rat cerebrocortical synaptosomes independent of metabotropic glutamate receptor responses.
Topics: 4-Aminopyridine; Animals; Arachidonic Acid; Cerebral Cortex; Cycloleucine; Diglycerides; Glutamic Acid; In Vitro Techniques; Male; Nerve Endings; Neurotoxins; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Signal Transduction; Synaptosomes | 1994 |
Glutamate stimulates the phosphorylation of glial fibrillary acidic protein in slices of immature rat hippocampus via a metabotropic receptor.
Topics: Animals; Autoradiography; Cycloleucine; Electrophoresis, Gel, Two-Dimensional; Excitatory Amino Acid Agonists; Female; Glial Fibrillary Acidic Protein; Glutamic Acid; Hippocampus; Ibotenic Acid; In Vitro Techniques; Kinetics; Male; Neurotoxins; Phosphates; Phosphoproteins; Phosphorylation; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1994 |
Is the heterologous expression of metabotropic glutamate receptors (mGluRs) an appropriate method to study the mGluR function? Experience with human embryonic kidney 293 cells transfected with mGluR1.
Topics: Alternative Splicing; Blotting, Northern; Calcium; Cell Division; Cell Line; Cell Survival; Colforsin; Cycloleucine; Embryo, Mammalian; Gene Expression; Glutamic Acid; Humans; Inositol Phosphates; Kidney; Neurotoxins; Pertussis Toxin; Receptors, Metabotropic Glutamate; RNA, Messenger; Thymidine; Transfection; Virulence Factors, Bordetella | 1994 |
Quisqualate and ACPD are agonists for a glutamate-activated current in identified Aplysia neurons.
Topics: Animals; Aplysia; Cells, Cultured; Cycloleucine; Dose-Response Relationship, Drug; Ganglia; Glutamates; Glutamic Acid; Membrane Potentials; Neural Inhibition; Neurons; Potassium Channels; Quisqualic Acid; Receptors, Glutamate; Synaptic Transmission | 1993 |
Pharmacology of metabotropic glutamate receptor inhibition of cyclic AMP formation in the adult rat hippocampus.
Topics: Alanine; Animals; Colforsin; Cyclic AMP; Cycloleucine; Glutamates; Glutamic Acid; Hippocampus; Male; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 1993 |
Glutamate uptake system in the presynaptic vesicle: glutamic acid analogs as inhibitors and alternate substrates.
Topics: Animals; Cattle; Cerebral Cortex; Cycloleucine; Cysteine; Glutamates; Glutamic Acid; Synaptic Vesicles; Tryptophan | 1993 |
Pharmacological characterization of metabotropic glutamate receptors in cultured cerebellar granule cells.
Topics: Alanine; Amino Acids, Diamino; Animals; Cells, Cultured; Cerebellum; Cyanobacteria Toxins; Cycloleucine; Drug Interactions; Enzyme Activation; Glutamates; Glutamic Acid; Ibotenic Acid; Magnesium; N-Methylaspartate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Quisqualic Acid; Rats; Receptors, Glutamate | 1993 |
L-2-amino-4-phosphonobutanoic acid and 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid reduce paired-pulse depression recorded from medial perforant path in the dentate gyrus of rat hippocampal slices.
Topics: Aminobutyrates; Animals; Atropine; Baclofen; Carbachol; Cycloleucine; Depression, Chemical; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Neural Pathways; Neurotransmitter Uptake Inhibitors; Picrotoxin; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Theophylline | 1993 |
Multiple subtypes of excitatory amino acid receptors coupled to the hydrolysis of phosphoinositides in rat brain.
Topics: Animals; Aspartic Acid; Brain; Cerebellum; Cerebral Cortex; Cycloleucine; Glutamates; Glutamic Acid; Hippocampus; Hydrolysis; Ibotenic Acid; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Amino Acid; Receptors, Glutamate | 1993 |
Attenuation of excitatory amino acid toxicity by metabotropic glutamate receptor agonists and aniracetam in primary cultures of cerebellar granule cells.
Topics: Animals; Cell Death; Cells, Cultured; Cerebellum; Cyclic AMP; Cycloleucine; Drug Synergism; Glutamates; Glutamic Acid; Inositol Phosphates; Kainic Acid; Pyrrolidinones; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glutamate | 1993 |
Role of the large extracellular domain of metabotropic glutamate receptors in agonist selectivity determination.
Topics: Animals; Cattle; Cycloleucine; Female; Glutamates; Glutamic Acid; Mutagenesis, Site-Directed; Neurotoxins; Oocytes; Quisqualic Acid; Receptors, Glutamate; Recombinant Fusion Proteins; Restriction Mapping; Xenopus | 1993 |
Glutamate activates phospholipase D in hippocampal slices of newborn and adult rats.
Topics: Aging; Animals; Animals, Newborn; Cycloleucine; Enzyme Activation; Glutamates; Glutamic Acid; Hippocampus; In Vitro Techniques; Phospholipase D; Rats | 1993 |
Characterization of the glutamate receptors mediating release of somatostatin from cultured hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Calcium; Cells, Cultured; Cycloleucine; Dizocilpine Maleate; Drug Synergism; Glutamic Acid; Hippocampus; Kainic Acid; N-Methylaspartate; Pyramidal Cells; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Somatostatin; Tetrodotoxin | 1996 |
Effects of quisqualic acid analogs on metabotropic glutamate receptors coupled to phosphoinositide hydrolysis in rat hippocampus.
Topics: Amino Acid Transport System X-AG; Animals; Animals, Newborn; ATP-Binding Cassette Transporters; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Hydrolysis; In Vitro Techniques; Male; Phosphatidylinositols; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1995 |
Presynaptic actions of glutamate receptor agonists in the CA1 region of rat hippocampus in vitro.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Magnesium; Male; Membrane Potentials; N-Methylaspartate; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Presynaptic | 1995 |
Respiratory effects produced by microinjection of L-glutamate and an uptake inhibitor of L-glutamate into the caudal subretrofacial area of the medulla.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Apnea; Blood Pressure; Cats; Cycloleucine; Dicarboxylic Acids; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Heart Rate; Kynurenic Acid; Male; Neurotoxins; Neurotransmitter Uptake Inhibitors; Piperazines; Pyrrolidines; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Respiration; Respiratory Function Tests; Tidal Volume; Trigeminal Caudal Nucleus | 1995 |
Sodium-dependent glutamate uptake as an activator of oxidative metabolism in primary astrocyte cultures from newborn rat.
Topics: Animals; Animals, Newborn; Astrocytes; Biotransformation; Cells, Cultured; Cycloleucine; Energy Metabolism; Glutamic Acid; Ketoglutaric Acids; Nerve Tissue Proteins; Oxidation-Reduction; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Sodium | 1995 |
Blockade of both epileptogenesis and glutamate release by (1S,3S)-ACPD, a presynaptic glutamate receptor agonist.
Topics: Animals; Cycloleucine; Epilepsy; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Male; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptosomes | 1995 |
Metabotropic and ionotropic transducers of glutamate signal inversely control cytoplasmic Ca2+ concentration and excitotoxicity in cultured cerebellar granule cells: pivotal role of protein kinase C.
Topics: Animals; Calcium; Cells, Cultured; Cerebellum; Cycloleucine; Cytosol; Glutamic Acid; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Second Messenger Systems | 1996 |
Components of glial responses to exogenous and synaptic glutamate in rat hippocampal microcultures.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Cells, Cultured; Cycloleucine; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Microglia; Neurons; Neurotoxins; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses; Tacrine | 1996 |
Glutamate-independent long term depression in rat hippocampus by activation GABAA receptors.
Topics: 2-Amino-5-phosphonovalerate; Adenosine; Alanine; Animals; Cycloleucine; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Kinetics; Kynurenic Acid; Male; Muscimol; Neuronal Plasticity; Neurotoxins; Pyramidal Cells; Rats; Rats, Wistar; Receptors, GABA-A | 1996 |
Modulation of 45Ca2+ influx into cells stably expressing recombinant human NMDA receptors by ligands acting at distinct recognition sites.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Calcium; Calcium Radioisotopes; Cycloleucine; Dithionitrobenzoic Acid; Dithiothreitol; Excitatory Amino Acid Agonists; Glutamic Acid; Glycine; Humans; Kainic Acid; L Cells; Ligands; Mice; Neurotoxins; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Spermine; Sulfhydryl Reagents | 1996 |
(2S,4S)-2-amino-4-(4,4-diphenylbut-1-yl)- pentane-1,5-dioic acid: a potent and selective antagonist for metabotropic glutamate receptors negatively linked to adenylate cyclase.
Topics: Adenylyl Cyclases; Amino Acids, Dicarboxylic; Animals; Binding, Competitive; Brain; Cell Line; Cell Membrane; Cycloleucine; Glutamic Acid; Humans; Indicators and Reagents; Inositol Phosphates; Kinetics; Neurotoxins; Phosphatidylinositols; Rats; Receptors, Metabotropic Glutamate | 1996 |
Interaction between A1 adenosine and class II metabotropic glutamate receptors in the regulation of purine and glutamate release from rat hippocampal slices.
Topics: Adenosine; Animals; Cycloleucine; Cyclopropanes; Excitatory Amino Acids; Glutamic Acid; Glycine; Hippocampus; Male; Neuroprotective Agents; Neurotoxins; Organ Culture Techniques; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, Purinergic P1; Xanthines | 1996 |
Opposing effects on blood pressure following the activation of metabotropic and ionotropic glutamate receptors in raphe obscurus in the anaesthetized rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analysis of Variance; Animals; Benzoates; Blood Pressure; Cycloleucine; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hypertension; Male; Microinjections; N-Methylaspartate; Neurotoxins; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Structure-Activity Relationship; Valine | 1996 |
(2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a potent and selective antagonist of type 2 metabotropic glutamate receptors.
Topics: Animals; Cell Line; Cell Survival; Cells, Cultured; Cerebral Cortex; Cricetinae; Cyclic AMP; Cycloleucine; Cyclopropanes; Excitatory Amino Acid Antagonists; Fetus; Glutamic Acid; Glycine; Kidney; Kinetics; Mice; N-Methylaspartate; Neuroglia; Neurons; Neurotoxins; Phosphatidylinositols; Receptors, Metabotropic Glutamate; Structure-Activity Relationship | 1996 |
Heterologous modulation of inhibitory synaptic transmission by metabotropic glutamate receptors in cultured hippocampal neurons.
Topics: Animals; Benzoates; Cells, Cultured; Cycloleucine; Dicarboxylic Acids; Evoked Potentials; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hippocampus; Neural Inhibition; Neurons; Neurotransmitter Uptake Inhibitors; Patch-Clamp Techniques; Pyrrolidines; Rats; Receptors, Metabotropic Glutamate; Synaptic Transmission | 1996 |
Coupling of metabotropic glutamate receptors to phosphoinositide mobilisation and inhibition of cyclic AMP generation in the guinea-pig cerebellum.
Topics: 2-Chloroadenosine; Animals; Cerebellum; Colforsin; Cyclic AMP; Cycloleucine; Female; Glutamic Acid; Glycine; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Phosphatidylinositols; Receptors, Metabotropic Glutamate; Resorcinols | 1996 |
L-Glutamate-induced responses in OFF-type bipolar cells of the cat retina.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Aspartic Acid; Calcium; Cats; Chlorides; Cycloleucine; Dose-Response Relationship, Drug; Glutamic Acid; Glycine; In Vitro Techniques; Ion Transport; Kainic Acid; Membrane Potentials; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Potassium; Retina; Retinal Cone Photoreceptor Cells; Sodium | 1996 |
Developmental changes in glutamate receptor-activated translocation of protein kinase C in cerebellar granule neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Biological Transport; Carcinogens; Cells, Cultured; Cerebellum; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Magnesium; N-Methylaspartate; Neurotoxins; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Tritium | 1996 |
Metabotropic glutamate receptors, transmitter output and fatty acids: studies in rat brain slices.
Topics: Acetophenones; Animals; Arachidonic Acid; Aspartic Acid; Corpus Striatum; Cyclohexanones; Cycloleucine; Cyclooxygenase Inhibitors; Fatty Acids; Glutamic Acid; In Vitro Techniques; Indomethacin; Lipoprotein Lipase; Male; Masoprocol; Membrane Potentials; Neurotoxins; Oleic Acids; Parietal Lobe; Phospholipases A; Phospholipases A2; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Serum Albumin; Stearic Acids | 1996 |
Modulation of excitatory synaptic transmission by low concentrations of glutamate in cultured rat hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Aspartic Acid; Benzothiadiazines; Calcium; Cells, Cultured; Cycloleucine; Evoked Potentials; Glutamic Acid; Hippocampus; Neurons; Patch-Clamp Techniques; Pertussis Toxin; Rats; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Virulence Factors, Bordetella; Wheat Germ Agglutinins | 1996 |
Carnitine and choline derivatives containing a trimethylamine group prevent ammonia toxicity in mice and glutamate toxicity in primary cultures of neurons.
Topics: Ammonia; Animals; Carnitine; Cells, Cultured; Choline; Cycloleucine; Glutamic Acid; Male; Methylamines; Mice; Neurons; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1996 |
The synergism between ACPD and arachidonic acid on glutamate release in hippocampus is age-dependent.
Topics: Aging; Animals; Arachidonic Acid; Cycloleucine; Drug Synergism; Excitatory Amino Acid Agonists; Glutamic Acid; Heparin; Hippocampus; Male; Rats; Rats, Wistar | 1996 |
Thyrotropin-releasing hormone (TRH) attenuates glutamate-stimulated increases in calcium in primary neuronal cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Cells, Cultured; Cycloleucine; Electrophysiology; Glutamic Acid; Intracellular Membranes; Ion Channel Gating; N-Methylaspartate; Neurons; Rats; Thyrotropin-Releasing Hormone | 1996 |
Tachycardia after glutamate injection in rat spinal cord is not blocked by kynurenate or mimicked by metabotropic agonists.
Topics: Aminobutyrates; Analysis of Variance; Animals; Blood Pressure; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Rate; Injections, Spinal; Kainic Acid; Kynurenic Acid; N-Methylaspartate; Rats; Rats, Inbred WKY; Receptors, Metabotropic Glutamate; Spinal Cord; Tachycardia | 1996 |
Potentiation of spontaneous acetylcholine release from motor nerve terminals by glutamate in Xenopus tadpoles.
Topics: Acetylcholine; Alanine; Animals; Calcium; Calcium Channel Blockers; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Larva; Motor Endplate; N-Methylaspartate; Neurotoxins; Quisqualic Acid; Second Messenger Systems; Verapamil; Xenopus laevis | 1996 |
Excitatory amino acid regulation of astrocyte proteoglycans.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; CD57 Antigens; Cell Membrane; Cells, Cultured; Chondroitin Sulfates; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Heparitin Sulfate; Hippocampus; Immunohistochemistry; Kainic Acid; N-Methylaspartate; Protein Kinase C; Rats; Receptors, Metabotropic Glutamate; Subcellular Fractions; Sulfates; Sulfur Radioisotopes | 1996 |
Postsynaptic glutamate uptake in rat cerebellar Purkinje cells.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Benzoates; Cycloleucine; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Ion Channel Gating; Kynurenic Acid; Membrane Potentials; Monosaccharide Transport Proteins; Neuroprotective Agents; Purkinje Cells; Rats; Receptors, Metabotropic Glutamate; Synaptic Transmission; Tetrodotoxin | 1996 |
Feeding-evoked dopamine release in the nucleus, accumbens: regulation by glutamatergic mechanisms.
Topics: Animals; Cycloleucine; Dopamine; Excitatory Amino Acid Antagonists; Feeding Behavior; Glutamic Acid; Kynurenic Acid; Male; Microdialysis; Nucleus Accumbens; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Ventral Tegmental Area | 1997 |
Metabotropic glutamate receptor activation modulates kainate and serotonin calcium response in astrocytes.
Topics: Amino Acids, Dicarboxylic; Aminobutyrates; Animals; Astrocytes; Biological Transport; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Cerebral Cortex; Cycloleucine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Nimodipine; Pertussis Toxin; Phorbol 12,13-Dibutyrate; Protein Kinase C; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Second Messenger Systems; Serotonin; Suprachiasmatic Nucleus; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1997 |
Excitatory amino acid receptors coupled to the phosphoinositide pathway in Bergmann glia.
Topics: Animals; Astrocytes; Calcium Channels; Cells, Cultured; Cerebellum; Chick Embryo; Cycloleucine; Glutamic Acid; Hydrolysis; Neuroglia; Phosphatidylinositols; Quisqualic Acid; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Stimulation, Chemical | 1997 |
Conformational analysis of glutamic acid analogues as probes of glutamate receptors using molecular modelling and NMR methods. Comparison with specific agonists.
Topics: Animals; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Molecular Probes; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Xenopus | 1997 |
Human metabotropic glutamate receptor 1: mRNA distribution, chromosome localization and functional expression of two splice variants.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Brain; Calcium; Cell Line; Chromosome Mapping; Chromosomes, Human, Pair 6; Cloning, Molecular; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Genetic Variation; Glutamic Acid; Humans; Membrane Potentials; Molecular Sequence Data; Oocytes; Open Reading Frames; Rats; Receptors, AMPA; Recombinant Proteins; RNA, Messenger; Sequence Deletion; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Transcription, Genetic; Transfection; Xenopus | 1996 |
Pressor and sympathetic responses to excitatory amino acids are not augmented in the ventrolateral medulla of Dahl salt-sensitive rats.
Topics: Analysis of Variance; Animals; Blood Pressure; Body Weight; Cycloleucine; Diet, Sodium-Restricted; Excitatory Amino Acid Agonists; Glutamic Acid; Heart Rate; Male; Medulla Oblongata; Microinjections; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Inbred Strains; Sodium, Dietary; Splanchnic Circulation; Sympathetic Nervous System | 1997 |
Differential regulation of neuronal proteoglycans by activation of excitatory amino acid receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Chondroitin Sulfate Proteoglycans; Cycloleucine; DNA Primers; Excitatory Amino Acid Agonists; Fetus; Glutamic Acid; Glycosylphosphatidylinositols; Glypicans; Heparan Sulfate Proteoglycans; Hippocampus; Lectins, C-Type; Membrane Proteins; N-Methylaspartate; Nerve Tissue Proteins; Neurocan; Neurons; Neuroprotective Agents; Polymerase Chain Reaction; Proteoglycans; Rats; Receptors, Glutamate; RNA, Messenger; Transcription, Genetic | 1997 |
Regulation of cerebral microvessels by glutamatergic mechanisms.
Topics: 2-Amino-5-phosphonovalerate; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Cerebrovascular Circulation; Cycloleucine; Electric Stimulation; Evoked Potentials; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Male; Microcirculation; N-Methylaspartate; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Synapses; Vasoconstriction; Vasodilation | 1997 |
G-protein-mediated desensitization of metabotropic glutamatergic and muscarinic responses in CA3 cells in rat hippocampus.
Topics: Animals; Cations; Cyclic AMP-Dependent Protein Kinases; Cycloleucine; Electrophysiology; Glutamic Acid; GTP-Binding Proteins; Hippocampus; Methacholine Chloride; Muscarinic Agonists; Neurons; Neuroprotective Agents; Organ Culture Techniques; Protein Kinase C; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, Muscarinic; Sensitivity and Specificity | 1997 |
Characterization of metabotropic glutamate receptors in rat C6 glioma cells.
Topics: Animals; Brain Neoplasms; Cell Membrane; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glioma; Glutamic Acid; Guanylyl Imidodiphosphate; Kinetics; Neuroprotective Agents; Radioligand Assay; Rats; Receptors, Metabotropic Glutamate; Tumor Cells, Cultured | 1997 |
N-acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells.
Topics: Animals; Calcium; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cycloleucine; Dipeptides; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Fetus; Glutamic Acid; Histamine H1 Antagonists; Humans; Hydrolysis; Kidney; Neuropeptides; Neuroprotective Agents; Phosphates; Rats; Receptors, Metabotropic Glutamate; Recombinant Fusion Proteins; Transfection | 1997 |
Metabotropic glutamate receptor subtype mGluR1alpha stimulates the secretion of the amyloid beta-protein precursor ectodomain.
Topics: Amyloid beta-Protein Precursor; Benzoates; Cell Line; Cycloleucine; Enzyme Activation; Excitatory Amino Acid Antagonists; Gene Expression; Glutamic Acid; Glycine; GTP-Binding Proteins; Humans; Melitten; Phosphatidylinositols; Phospholipases A; Phospholipases A2; Protein Kinases; Quisqualic Acid; Receptors, Metabotropic Glutamate; Transfection; Type C Phospholipases | 1997 |
Glutamate-dependent activation of NF-kappaB during mouse cerebellum development.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Age Factors; Animals; Antibody Specificity; Cell Nucleus; Cerebellum; Cycloleucine; Cytoplasm; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression Regulation, Developmental; Glutamic Acid; Injections, Intraperitoneal; Mice; Mice, Transgenic; N-Methylaspartate; Neuroprotective Agents; Neurotransmitter Agents; NF-kappa B; Transgenes | 1997 |
Type 2 metabotropic glutamate (mGlu) receptors tonically inhibit transmitter release in rat caudate nucleus: in vivo studies with (2S,1'S,2'S,3'R)-2-(2'-carboxy-3'-phenylcyclopropyl)glycine, a new potent and selective antagonist.
Topics: Animals; Benzoates; Caudate Nucleus; Corpus Striatum; Cyclic AMP; Cycloleucine; Cyclopropanes; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Male; Neurotransmitter Agents; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1997 |
Influences of excitatory amino acid receptor agonists on nucleus of the solitary tract neurons receiving aortic depressor nerve inputs.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aorta; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Iontophoresis; Kainic Acid; Male; N-Methylaspartate; Nervous System Physiological Phenomena; Neurons; Rats; Rats, Sprague-Dawley; Solitary Nucleus | 1997 |
New analogues of ACPD with selective activity for group II metabotropic glutamate receptors.
Topics: Animals; CHO Cells; Cricetinae; Cycloleucine; Glutamic Acid; In Vitro Techniques; Receptors, Metabotropic Glutamate; Second Messenger Systems; Stereoisomerism; Structure-Activity Relationship | 1997 |
Ontogeny of non-NMDA glutamate receptors in rat barrel field cortex: I. Metabotropic receptors.
Topics: Aging; Animals; Animals, Newborn; Autoradiography; Cycloleucine; Gene Expression Regulation, Developmental; Glutamic Acid; Immunohistochemistry; Neuroprotective Agents; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Somatosensory Cortex; Tritium; Vibrissae | 1997 |
Strategies for receptor control of neurotransmitter release.
Topics: 4-Aminopyridine; Action Potentials; Animals; Calcium Channels; Cycloleucine; Elapid Venoms; Exocytosis; Glutamic Acid; Homeostasis; Models, Neurological; Neuroprotective Agents; Neurotoxins; Potassium Channels; Potassium Chloride; Protein Kinase C; Rats; Receptors, Metabotropic Glutamate; Receptors, Purinergic P1; Synaptosomes | 1998 |
Presynaptic depression at a calyx synapse: the small contribution of metabotropic glutamate receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Afferent Pathways; Aminobutyrates; Animals; Brain Stem; Cycloleucine; Electric Stimulation; Glutamic Acid; Glycine; Neuronal Plasticity; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synapses | 1997 |
Metabotropic glutamate autoreceptors on nerve terminals of crayfish muscle depress or facilitate release.
Topics: Animals; Astacoidea; Cycloleucine; Glutamic Acid; Membrane Potentials; Nerve Endings; Neuromuscular Junction; Receptors, Metabotropic Glutamate | 1997 |
Effects of the metabotropic glutamate receptor antagonist MCPG on phosphoinositide turnover and synaptic plasticity in visual cortex.
Topics: Action Potentials; Age Factors; Animals; Benzoates; Binding, Competitive; Cycloleucine; Electrophysiology; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Long-Term Potentiation; Neuronal Plasticity; Neuroprotective Agents; Phosphatidylinositols; Rats; Rats, Inbred Strains; Receptors, Metabotropic Glutamate; Synapses; Visual Cortex | 1998 |
Prostaglandins stimulate calcium-dependent glutamate release in astrocytes.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Astrocytes; Biological Transport; Calcium; Cells, Cultured; Cerebral Cortex; Cycloleucine; Glutamic Acid; Hippocampus; In Vitro Techniques; Prostaglandins; Rats; Receptors, AMPA; Receptors, Glutamate; Visual Cortex | 1998 |
Evidence for neuronal origin and metabotropic receptor-mediated regulation of extracellular glutamate and aspartate in rat striatum in vivo following electrical stimulation of the prefrontal cortex.
Topics: Animals; Aspartic Acid; Benzoates; Calcium; Corpus Striatum; Cycloleucine; Dicarboxylic Acids; Egtazic Acid; Electric Stimulation; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Glycine; Male; Neurons; Neurotransmitter Uptake Inhibitors; Prefrontal Cortex; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Tetrodotoxin; Time Factors | 1998 |
In vivo microdialysis reveals facilitatory metabotropic glutamate receptors regulating excitatory amino acid release in rat nucleus tractus solitarius.
Topics: Animals; Aspartic Acid; Benzoates; Calcium; Chromatography, High Pressure Liquid; Cycloleucine; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Glutamic Acid; Glycine; Kinetics; Male; Microdialysis; Neurotoxins; Rats; Rats, Inbred WKY; Receptors, Metabotropic Glutamate; Solitary Nucleus; Tetrodotoxin | 1998 |
Guanine nucleotides inhibit cAMP accumulation induced by metabotropic glutamate receptor activation.
Topics: Animals; Cyclic AMP; Cycloleucine; Glutamic Acid; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Monophosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hippocampus; Neurotoxins; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Thionucleotides | 1998 |
Modulation of GAP-43 mRNA by GABA and glutamate in cultured cerebellar granule cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Baclofen; Blotting, Northern; Cells, Cultured; Cerebellum; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Agonists; gamma-Aminobutyric Acid; GAP-43 Protein; Gene Expression Regulation, Developmental; Glial Fibrillary Acidic Protein; Glutamic Acid; Immunohistochemistry; In Situ Hybridization; Microtubule-Associated Proteins; Muscimol; N-Methylaspartate; Neurons; Neuroprotective Agents; Piperazines; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1998 |
Aminobicyclo[2.2.1.]heptane dicarboxylic acids (ABHD), rigid analogs of ACPD and glutamic acid: synthesis and pharmacological activity on metabotropic receptors mGluR1 and mGluR2.
Topics: Chromatography, High Pressure Liquid; Cycloleucine; Dicarboxylic Acids; Gas Chromatography-Mass Spectrometry; Glutamic Acid; Isomerism; Models, Chemical; Molecular Conformation; Norbornanes; Receptors, Metabotropic Glutamate | 1998 |
Prenatal ethanol exposure enhances glutamate release stimulated by quisqualate in rat cerebellar granule cell cultures.
Topics: Alcoholism; Amino Acids; Animals; Cells, Cultured; Cerebellum; Cycloleucine; Dizocilpine Maleate; Ethanol; Female; Glutamic Acid; Kainic Acid; N-Methylaspartate; Neurons; Potassium Chloride; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate | 1998 |
Regulation of the nigrostriatal pathway by metabotropic glutamate receptors during development.
Topics: Alanine; Animals; Cerebral Cortex; Corpus Striatum; Cycloleucine; Excitatory Amino Acid Antagonists; Glutamic Acid; Microscopy, Confocal; Nerve Fibers; Neural Pathways; Neurons; Neuroprotective Agents; Organ Culture Techniques; Phytohemagglutinins; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Second Messenger Systems; Substantia Nigra; Tyrosine 3-Monooxygenase | 1998 |
Intracellular free calcium dynamics in stretch-injured astrocytes.
Topics: Animals; Animals, Newborn; Astrocytes; Calcium; Cells, Cultured; Cerebral Cortex; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Inositol Phosphates; Intracellular Fluid; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Thapsigargin | 1998 |
Effect of glutamate receptor agonists on catecholamine secretion in bovine chromaffin cells.
Topics: Adrenal Medulla; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Catecholamines; Cattle; Cells, Cultured; Chromaffin System; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Kainic Acid; Membrane Potentials; N-Methylaspartate; Nicotine; Receptors, Glutamate | 1998 |
Presynaptic mGlu1 type receptors potentiate transmitter output in the rat cortex.
Topics: Animals; Benzoates; Bridged Bicyclo Compounds; Cycloleucine; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Indans; Microdialysis; Parietal Lobe; Rats; Receptors, Metabotropic Glutamate; Receptors, Presynaptic; Resorcinols | 1998 |
Sensitivity and density of glutamate receptor subtypes in the hippocampal formation are altered in pentylenetetrazole-kindled rats.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Brain Chemistry; Convulsants; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Inositol Phosphates; Kindling, Neurologic; Male; Neuroprotective Agents; Pentylenetetrazole; Radioligand Assay; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Tritium | 1998 |
Glutamate-stimulated neuropeptide Y mRNA expression in the rat dentate gyrus: a prominent role of metabotropic glutamate receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Dentate Gyrus; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Glutamic Acid; Hippocampus; Injections; Injections, Intraperitoneal; Male; N-Methylaspartate; Neuropeptide Y; Neuropeptides; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; RNA, Messenger | 1998 |
Changes in GluR4 expression induced by metabotropic receptor activation in radial glia cultures.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Cerebellum; Chick Embryo; Cycloleucine; Glutamic Acid; Kainic Acid; Kinetics; N-Methylaspartate; Neuroglia; Polymerase Chain Reaction; Receptor, Metabotropic Glutamate 5; Receptors, AMPA; Receptors, Metabotropic Glutamate; Retina; RNA, Messenger; Transcription, Genetic; Up-Regulation | 1998 |
Glutamate locally activates dendritic outputs of thalamic interneurons.
Topics: Animals; Cats; Cycloleucine; Dendrites; Geniculate Bodies; Glutamic Acid; In Vitro Techniques; Interneurons; Neural Inhibition; Patch-Clamp Techniques; Rats; Receptors, Metabotropic Glutamate; Tetrodotoxin; Thalamus | 1998 |
Characterization of neuroprotection from excitotoxicity by moderate and profound hypothermia in cultured cortical neurons unmasks a temperature-insensitive component of glutamate neurotoxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Survival; Cells, Cultured; Cerebral Cortex; Cold Temperature; Cycloleucine; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Excitatory Amino Acids; Fluorescent Dyes; Glutamic Acid; Humans; Hypothermia, Induced; Kainic Acid; Mice; N-Methylaspartate; Neuroglia; Neurons; Neurotoxins; Synapses | 1998 |
Low-affinity kainate receptors and long-lasting depression of NMDA-receptor-mediated currents in rat superficial dorsal horn.
Topics: Action Potentials; Animals; Calcium; Cycloleucine; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Ganglia, Spinal; Glutamic Acid; Indoles; Ion Channel Gating; Kainic Acid; Male; N-Methylaspartate; Neurons, Afferent; Neuroprotective Agents; Oximes; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Spinal Nerve Roots; Synaptic Transmission | 1998 |
Stimulation of Na+-K+-2Cl- cotransporter in neuronal cells by excitatory neurotransmitter glutamate.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Bumetanide; Carrier Proteins; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agents; Gene Expression Regulation; Glutamic Acid; Humans; Kinetics; N-Methylaspartate; Neuroblastoma; Neurons; Potassium; Receptors, Glutamate; Sodium-Potassium-Chloride Symporters; Tumor Cells, Cultured | 1998 |
Functional coupling of human metabotropic glutamate receptor hmGlu1d: comparison to splice variants hmGlu1a and -1b.
Topics: Adenylate Cyclase Toxin; Aequorin; Alternative Splicing; Amino Acid Sequence; Animals; Calcium; Cell Line; CHO Cells; Cricetinae; Cycloleucine; Excitatory Amino Acid Agonists; Genetic Variation; Glutamic Acid; Humans; Inositol Phosphates; Molecular Sequence Data; Pertussis Toxin; Polymerase Chain Reaction; Receptors, Metabotropic Glutamate; Recombinant Fusion Proteins; Transfection; Virulence Factors, Bordetella | 1998 |
Receptor-activated Ca2+ increases in vibrodissociated cortical astrocytes: a nonenzymatic method for acute isolation of astrocytes.
Topics: Animals; Astrocytes; Calcium; Cell Separation; Cell Size; Cells, Cultured; Cerebral Cortex; Cycloleucine; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Glutamic Acid; Immunohistochemistry; Indans; Norepinephrine; Phenylephrine; Potassium; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Neurotransmitter; Serotonin | 1998 |
Effect of nitrous oxide on excitatory and inhibitory synaptic transmission in hippocampal cultures.
Topics: Animals; Cesium; Choline; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Feedback; Glutamic Acid; Hippocampus; Kainic Acid; Ketamine; Magnesium; Neural Inhibition; Neurons; Neuroprotective Agents; Nitrous Oxide; Nootropic Agents; Propionates; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, GABA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1998 |
Conformational changes of the smooth endoplasmic reticulum are facilitated by L-glutamate and its receptors in rat Purkinje cells.
Topics: Alanine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apnea; Bradycardia; Calcium Signaling; Cycloleucine; Dendrites; Endoplasmic Reticulum, Smooth; Excitatory Amino Acid Antagonists; Glutamic Acid; Hypoxia, Brain; Immunohistochemistry; Injections, Intraventricular; Kainic Acid; Male; N-Methylaspartate; Nerve Tissue Proteins; Neuroprotective Agents; Purkinje Cells; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Respiration | 1998 |
The potent mGlu receptor antagonist LY341495 identifies roles for both cloned and novel mGlu receptors in hippocampal synaptic plasticity.
Topics: Aging; Amino Acids; Animals; Binding, Competitive; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Cycloleucine; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hippocampus; Humans; In Vitro Techniques; Long-Term Potentiation; Neuronal Plasticity; Rats; Receptors, Metabotropic Glutamate; Recombinant Proteins; Resorcinols; Transfection; Xanthenes | 1998 |
LTP occludes the interaction between arachidonic acid and ACPD and NGF and ACPD.
Topics: Animals; Arachidonic Acid; Calcium; Cycloleucine; Dentate Gyrus; Drug Interactions; Electric Stimulation; Glutamic Acid; Hippocampus; Long-Term Potentiation; Male; Nerve Growth Factors; Perforant Pathway; Potassium Chloride; Rats; Rats, Wistar; Synaptosomes | 1998 |
Metabotropic glutamate receptor agonists reduce glutamate release from cultured astrocytes.
Topics: Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Culture Media, Conditioned; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Sodium-Potassium-Exchanging ATPase | 1999 |
Local glutamatergic and GABAergic synaptic circuits and metabotropic glutamate receptors in the hypothalamic paraventricular and supraoptic nuclei.
Topics: Animals; Cycloleucine; Electric Stimulation; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Models, Neurological; Neurons; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Rats; Receptors, Metabotropic Glutamate; Supraoptic Nucleus; Synapses | 1998 |
mGluR7-like metabotropic glutamate receptors inhibit NMDA-mediated excitotoxicity in cultured mouse cerebellar granule neurons.
Topics: Animals; Calcium Channels; Cell Death; Cells, Cultured; Cerebellum; Cyclic GMP; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Mice; Microtubule-Associated Proteins; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxins; Patch-Clamp Techniques; Phosphoserine; Propionates; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1999 |
The effects of excitatory amino acids on isolated gut segments of the rat.
Topics: Animals; Aspartic Acid; Cycloleucine; Digestive System; Digestive System Physiological Phenomena; Excitatory Amino Acid Agonists; Excitatory Amino Acids; Female; Glutamic Acid; In Vitro Techniques; Kainic Acid; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth; N-Methylaspartate; Neuroprotective Agents; Rats; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 1999 |
Cardiovascular responses to microinjections of excitatory amino acids into the area postrema of the rat.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Intravenous; Animals; Blood Pressure; Bradycardia; Cerebral Ventricles; Cycloleucine; Decerebrate State; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; Male; Microinjections; N-Methylaspartate; Neuroprotective Agents; Rats; Rats, Wistar; Tachycardia; Urethane | 1999 |
Group I metabotropic glutamate receptors mediate phospholipase D stimulation in rat cultured astrocytes.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Astrocytes; Benzoates; Carcinogens; Cerebellum; Cerebral Cortex; Cycloleucine; Dose-Response Relationship, Drug; Enzyme Activation; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hippocampus; Neurons; Neuroprotective Agents; Norepinephrine; Phospholipase D; Phosphorus Radioisotopes; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Sympathomimetics; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1999 |
Expression and signaling of group I metabotropic glutamate receptors in astrocytes and microglia.
Topics: Animals; Astrocytes; Benzoates; Brain; Brain Chemistry; Calcium; Cells, Cultured; Cycloleucine; DNA Primers; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Gene Expression; Glutamic Acid; Glycine; In Situ Hybridization; Inositol 1,4,5-Trisphosphate; Microglia; Neuroprotective Agents; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction | 1999 |
Glutamate regulates IP3-type and CICR stores in the avian cochlear nucleus.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alanine; Animals; Benzoates; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Chelating Agents; Chick Embryo; Cochlear Nucleus; Cyclic AMP; Cycloleucine; Cysteine; Egtazic Acid; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Fura-2; Gallic Acid; Glutamic Acid; Glycine; Ibotenic Acid; Inositol 1,4,5-Trisphosphate Receptors; Ion Channel Gating; Neurons; Neuroprotective Agents; Neurotransmitter Agents; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Receptors, Cytoplasmic and Nuclear; Ryanodine; Second Messenger Systems; Thionucleotides | 1999 |
Activation of NMDA receptors protects against glutamate neurotoxicity in the retina: evidence for the involvement of neurotrophins.
Topics: 2-Amino-5-phosphonovalerate; Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Cycloleucine; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Kainic Acid; N-Methylaspartate; Nerve Growth Factors; Neuroprotective Agents; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptor Protein-Tyrosine Kinases; Receptor, Ciliary Neurotrophic Factor; Receptors, N-Methyl-D-Aspartate; Receptors, Nerve Growth Factor; Retina | 1999 |
Activation of p42 mitogen-activated protein kinase by arachidonic acid and trans-1-amino-cyclopentyl-1,3- dicarboxylate impacts on long-term potentiation in the dentate gyrus in the rat: analysis of age-related changes.
Topics: Aging; Animals; Arachidonic Acid; Cycloleucine; Dentate Gyrus; Drug Synergism; Electric Stimulation; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glutamic Acid; Long-Term Potentiation; Male; Mitogen-Activated Protein Kinase 1; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate | 1999 |
Glutamate-triggered events inducing corticostriatal long-term depression.
Topics: Animals; Cerebral Cortex; Corpus Striatum; Cycloleucine; Electric Stimulation; Electrophysiology; Glutamic Acid; Hydroxylamine; In Vitro Techniques; Male; Membrane Potentials; Neuronal Plasticity; Neurons; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Sulpiride; Synaptic Transmission; Time Factors | 1999 |
Synaptic depression induced by pharmacological activation of metabotropic glutamate receptors in the perirhinal cortex in vitro.
Topics: Animals; Cycloleucine; Cyclopropanes; Electric Stimulation; Entorhinal Cortex; Excitatory Amino Acid Agonists; Female; Glutamic Acid; Glycine; Hippocampus; Male; Neocortex; Neuronal Plasticity; Organ Culture Techniques; Propionates; Rats; Rats, Inbred Strains; Rats, Wistar; Receptors, Metabotropic Glutamate; Resorcinols; Synaptic Transmission; Temporal Lobe | 1999 |
Endogenous activation of metabotropic glutamate receptors in neocortical development causes neuronal calcium oscillations.
Topics: Animals; Calcium; Cycloleucine; Excitatory Amino Acid Agonists; Glutamic Acid; Lysine; Mice; Microscopy, Fluorescence; N-Methylaspartate; Neocortex; Neuroglia; Neurons; Neuroprotective Agents; Protein Isoforms; Receptors, Metabotropic Glutamate; Time Factors | 1999 |
Regulation of NMDA-stimulated [14C]GABA and [3H]acetylcholine release by striatal glutamate and dopamine receptors.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzoates; Carbon Radioisotopes; Corpus Striatum; Cycloleucine; Dopamine Agonists; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Kainic Acid; Male; N-Methylaspartate; Proline; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Tritium | 1999 |
Potentiation of glutamatergic agonist-induced inositol phosphate formation by basic fibroblast growth factor is related to developmental features in hippocampal cultures: neuronal survival and glial cell proliferation.
Topics: Animals; Antimetabolites, Antineoplastic; Benzoates; Cell Division; Cell Survival; Cells, Cultured; Cellular Senescence; Cycloleucine; Cytarabine; Epidermal Growth Factor; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Fetus; Fibroblast Growth Factor 2; Glutamic Acid; Glycine; Hippocampus; Inositol Phosphates; Neuroglia; Neurons; Neuroprotective Agents; Quinoxalines; Quisqualic Acid; Rats; Receptors, AMPA; Receptors, Kainic Acid; Type C Phospholipases | 1999 |
Correlation of glutamate-induced apoptosis with caspase activities in cultured rat cerebral cortical neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Apoptosis; Caspase 1; Caspase 3; Caspases; Cell Death; Cells, Cultured; Cerebral Cortex; Chromatin; Cycloleucine; Cysteine Proteinase Inhibitors; Embryo, Mammalian; Enzyme Precursors; Excitatory Amino Acid Agonists; Glutamic Acid; Kinetics; L-Lactate Dehydrogenase; Neurons; Rats; Time Factors | 1999 |
Locomotor activity and accumbens Fos expression driven by ventral hippocampal stimulation require D1 and D2 receptors.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthetics, Local; Animals; Benzazepines; Brain Chemistry; Cycloleucine; Dextroamphetamine; Dopamine Agents; Dopamine Antagonists; Excitatory Amino Acid Agonists; Genes, Immediate-Early; Glutamic Acid; Haloperidol; Hippocampus; Kainic Acid; Lidocaine; Locomotion; Male; N-Methylaspartate; Neural Pathways; Neuroprotective Agents; Nucleus Accumbens; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2 | 1999 |
Presynaptic group 1 metabotropic glutamate receptors may contribute to the expression of long-term potentiation in the hippocampal CA1 region.
Topics: Animals; Azetidinecarboxylic Acid; Calcium; Cycloleucine; Dicarboxylic Acids; Diglycerides; Electric Stimulation; Electroencephalography; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycine; Hippocampus; Long-Term Potentiation; Male; Neuroprotective Agents; Neurotransmitter Uptake Inhibitors; Presynaptic Terminals; Pyrrolidines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Resorcinols; Synaptosomes | 1999 |
Age-related changes in synaptic function: analysis of the effect of dietary supplementation with omega-3 fatty acids.
Topics: Aging; Animals; Arachidonic Acid; Cycloleucine; Dentate Gyrus; Docosahexaenoic Acids; Eating; Excitatory Postsynaptic Potentials; Fatty Acids, Omega-3; Glutamic Acid; Long-Term Potentiation; Male; Neurons; Neuroprotective Agents; Perforant Pathway; Potassium Chloride; Rats; Rats, Wistar; Synapses; Synaptic Transmission; Synaptosomes | 1999 |
Contribution of Ca(2+)-permeable AMPA/KA receptors to glutamate-induced Ca(2+) rise in embryonic lumbar motoneurons in situ.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channel Blockers; Cycloleucine; Embryo, Mammalian; Excitatory Amino Acid Antagonists; Glutamic Acid; In Vitro Techniques; Kainic Acid; Lumbosacral Region; Motor Neurons; Neurotoxins; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Kainic Acid; Spider Venoms; Spinal Cord | 2000 |
Alterations in calcium-mediated signal transduction after traumatic injury of cortical neurons.
Topics: Animals; Brain Injuries; Calcium; Calcium Signaling; Cells, Cultured; Cerebral Cortex; Cycloleucine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; N-Methylaspartate; Neuroglia; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Thapsigargin | 1999 |
Mobilisation of intracellular Ca2+ by mGluR5 metabotropic glutamate receptor activation in neonatal rat cultured dorsal root ganglia neurones.
Topics: Animals; Animals, Newborn; Calcium; Calcium Channel Blockers; Cells, Cultured; Cycloleucine; Cyclopropanes; Dantrolene; Fluorescence; Ganglia, Spinal; Glutamic Acid; Glycine; Indans; Phenylacetates; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Ryanodine; Ryanodine Receptor Calcium Release Channel; Stereoisomerism | 2000 |
Axonal stratification patterns and glutamate-gated conductance mechanisms in zebrafish retinal bipolar cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminobutyrates; Animals; Axons; Chlorides; Cycloleucine; Dendrites; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Glutamic Acid; In Vitro Techniques; Isoquinolines; Kainic Acid; Neurons; Picrotoxin; Retina; Strychnine; Zebrafish | 2000 |
Physiological activation of presynaptic metabotropic glutamate receptors increases intracellular calcium and glutamate release.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Axons; Brain Stem; Calcium; Chromones; Cycloleucine; Dendrites; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Fluorometry; Glutamic Acid; Glycine Agents; GTP-Binding Proteins; In Vitro Techniques; Lampreys; Larva; Membrane Potentials; N-Methylaspartate; Neuronal Plasticity; Neuroprotective Agents; Patch-Clamp Techniques; Presynaptic Terminals; Quisqualic Acid; Receptors, Metabotropic Glutamate; Strychnine; Tetrodotoxin | 2000 |
Glutamate-mediated neuroprotection against N-methyl-D-aspartate toxicity: a role for metabotropic glutamate receptors.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Cell Death; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hippocampus; N-Methylaspartate; Neurons; Neuroprotective Agents; Oligodeoxyribonucleotides, Antisense; Organ Culture Techniques; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Tetrodotoxin | 2000 |
Control of dendritic outputs of inhibitory interneurons in the lateral geniculate nucleus.
Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cats; Cycloleucine; Dendrites; GABA Antagonists; Geniculate Bodies; Glutamic Acid; In Vitro Techniques; Interneurons; Magnesium; Muscarinic Agonists; Neural Inhibition; Nicotinic Agonists; Patch-Clamp Techniques; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Tetrodotoxin | 2000 |
Dendritic release of glutamate suppresses synaptic inhibition of pyramidal neurons in rat neocortex.
Topics: Action Potentials; Animals; Botulinum Toxins; Calcium; Cycloleucine; Dendrites; Egtazic Acid; Electrophysiology; Glutamic Acid; Guanosine Diphosphate; Interneurons; Neocortex; Neural Inhibition; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Synapses; Synaptic Transmission; Thionucleotides | 2000 |
Activation of metabotropic glutamate receptors increases extracellular adenosine in vivo.
Topics: Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Space; Glutamic Acid; Male; Methoxyhydroxyphenylglycol; Microdialysis; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Somatosensory Cortex | 2000 |
Traumatic injury of cultured astrocytes alters inositol (1,4,5)-trisphosphate-mediated signaling.
Topics: Animals; Animals, Newborn; Astrocytes; Brain Injuries; Cells, Cultured; Cycloleucine; Estrenes; Extracellular Space; Glutamic Acid; Inositol 1,4,5-Trisphosphate; Neomycin; Neuroprotective Agents; Phosphodiesterase Inhibitors; Protein Synthesis Inhibitors; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Signal Transduction; Stress, Mechanical; Type C Phospholipases | 2001 |
PLC-beta1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex.
Topics: Animals; Axons; Carbachol; Cell Differentiation; Cycloleucine; Glutamic Acid; Inositol 1,4,5-Trisphosphate; Isoenzymes; Mice; Mice, Knockout; Neuroprotective Agents; Phosphatidylinositols; Phospholipase C beta; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Receptors, Muscarinic; Somatosensory Cortex; Synaptic Transmission; Synaptosomes; Type C Phospholipases | 2001 |
Expression and regulation of Na pump isoforms in cultured cerebellar granule cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Biological Transport; Cerebellum; Cycloleucine; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Isoenzymes; Kainic Acid; N-Methylaspartate; Neurons; Neuroprotective Agents; Potassium Radioisotopes; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase | 2001 |
Inhibition of choline acetyltransferase by excitatory amino acids as a possible mechanism for cholinergic dysfunction in the central nervous system.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Chick Embryo; Choline O-Acetyltransferase; Cycloleucine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Kainic Acid; Neurons; NG-Nitroarginine Methyl Ester; Propionates; Quisqualic Acid; Retina; Signal Transduction; Tetrodotoxin; Trifluoperazine; Verapamil | 2001 |
Ca2+-dependent regulation of synaptic delta2 glutamate receptor density in cultured rat Purkinje neurons.
Topics: Actins; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Calcium Channels; Calpain; Cells, Cultured; Cerebellum; Cycloleucine; Dendrites; Endocytosis; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Glutamic Acid; Intracellular Fluid; Neuroprotective Agents; Purkinje Cells; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Synaptic Membranes; Synaptic Transmission | 2001 |
Changes in rat serum corticosterone after treatment with metabotropic glutamate receptor agonists or antagonists.
Topics: Adrenalectomy; Adrenocorticotropic Hormone; Amino Acids; Animals; Benzoates; Bridged Bicyclo Compounds; Corticosterone; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Male; Neuroprotective Agents; Paraventricular Hypothalamic Nucleus; Phenylacetates; Propionates; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Xanthenes | 2001 |
Visualization of IP(3) dynamics reveals a novel AMPA receptor-triggered IP(3) production pathway mediated by voltage-dependent Ca(2+) influx in Purkinje cells.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzoates; Blood Proteins; Calcium; Calcium Channels; Cell Membrane; Cells, Cultured; Cycloleucine; Cytoplasm; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Genetic Vectors; Glutamic Acid; Glycine; Green Fluorescent Proteins; Indicators and Reagents; Inositol 1,4,5-Trisphosphate; Luminescent Proteins; Membrane Potentials; Mice; Mice, Inbred ICR; Neuroprotective Agents; Patch-Clamp Techniques; Phosphoproteins; Purkinje Cells; Receptors, AMPA; Receptors, Metabotropic Glutamate; Sindbis Virus | 2001 |
Retrograde modulation of transmitter release by postsynaptic subtype 1 metabotropic glutamate receptors in the rat cerebellum.
Topics: Animals; Cerebellum; Cycloleucine; Excitatory Postsynaptic Potentials; Glutamic Acid; In Vitro Techniques; Male; Mice; Mice, Knockout; Nerve Fibers; Neurotransmitter Agents; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synapses; Synaptic Transmission | 2001 |
(1R,3S)-1-Aminocyclopentane-1,3-dicarboxylic acid (RS-ACPD) reduces intracellular glutamate levels in astrocytes.
Topics: Animals; Astrocytes; Biological Transport; Cell Size; Cells, Cultured; Cycloleucine; Enzyme Inhibitors; Glutamic Acid; Glutaminase; Hippocampus; Intracellular Fluid; Molecular Conformation; Neuroprotective Agents; Potassium; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Potassium-Exchanging ATPase | 2001 |
Magnesium decreases arterial pressure and inhibits cardiovascular responses induced by N-methyl-D-aspartate and metabotropic glutamate receptors stimulation in rostral ventrolateral medulla.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Heart Rate; Magnesium; Magnesium Chloride; Magnesium Sulfate; Male; Medulla Oblongata; N-Methylaspartate; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate | 2001 |
Presynaptic inhibition of GABAergic miniature currents by metabotropic glutamate receptor in the rat CNS.
Topics: Adenylyl Cyclases; Animals; Basal Nucleus of Meynert; Calbindins; Calcium; Cell Size; Choline O-Acetyltransferase; Cycloleucine; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Ion Channels; Neural Inhibition; Neuroprotective Agents; Potassium Channel Blockers; Presynaptic Terminals; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; S100 Calcium Binding Protein G; Synaptic Transmission | 2002 |
Carbon monoxide and metabotropic glutamate receptors in rat nucleus tractus solitarii: participation in cardiovascular effect.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Pressure; Carbon Monoxide; Cardiovascular System; Cycloleucine; Deuteroporphyrins; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Heart Rate; Heme Oxygenase (Decyclizing); Hemin; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Solitary Nucleus | 2002 |
Glutamate induces different neuronal conditioned responses than ACPD when used as a locally ionophoresed unconditioned stimulus in the cat motor cortex.
Topics: Acoustic Stimulation; Administration, Topical; Animals; Conditioning, Psychological; Cycloleucine; Discrimination, Psychological; Glutamic Acid; Humans; Iontophoresis; Motor Cortex; Neurons; Receptors, Metabotropic Glutamate | 2002 |
A pharmacological analysis of the contractile effects of glutamate on rat and human isolated gut smooth muscle strips.
Topics: Aged; Animals; Aspartic Acid; Cycloleucine; Evoked Potentials, Motor; Female; Gastric Fundus; Glutamic Acid; Humans; In Vitro Techniques; Intestine, Large; Male; Middle Aged; Muscle Contraction; Muscle, Smooth; Proline; Quisqualic Acid; Rats; Receptors, Glutamate; Rectum; Stomach | 2002 |
Translation of clock rhythmicity into neural firing in suprachiasmatic nucleus requires mGluR-PLCbeta4 signaling.
Topics: Action Potentials; Animals; Biological Clocks; Cell Cycle Proteins; Circadian Rhythm; Cycloleucine; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Glutamic Acid; Isoenzymes; Mice; Mice, Knockout; Mutation; Neurons; Neuroprotective Agents; Nuclear Proteins; Organ Culture Techniques; Period Circadian Proteins; Phospholipase C beta; Receptors, Metabotropic Glutamate; Signal Transduction; Suprachiasmatic Nucleus; Synaptic Transmission; Type C Phospholipases | 2003 |
Carbon monoxide mediates vasodilator effects of glutamate in isolated pressurized cerebral arterioles of newborn pigs.
Topics: Animals; Animals, Newborn; Arterioles; Brain; Carbon Monoxide; Cycloleucine; Endothelium, Vascular; Enzyme Inhibitors; Fluorescent Antibody Technique; Glutamic Acid; Heme Oxygenase (Decyclizing); In Vitro Techniques; Isoenzymes; Mesoporphyrins; Pressure; Receptors, N-Methyl-D-Aspartate; Swine; Vasodilation | 2003 |
Glutamate receptors regulate Na/K-ATPase in cerebellum neurons.
Topics: Animals; Cells, Cultured; Cerebellum; Cycloleucine; Glutamic Acid; Homeostasis; N-Methylaspartate; Neurons; Neurotoxins; Reactive Oxygen Species; Receptors, Glutamate; Sodium-Potassium-Exchanging ATPase | 2003 |
Glutamate causes a loss in human cerebral endothelial barrier integrity through activation of NMDA receptor.
Topics: Biological Transport; Blood-Brain Barrier; Blotting, Western; Brain; Calcium; Cells, Cultured; Cycloleucine; Dizocilpine Maleate; Endothelial Cells; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Neuroprotective Agents; Reactive Oxygen Species; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction | 2003 |
Hydroxyl radicals release in rat striatum involves metabotropic glutamate receptors.
Topics: Analysis of Variance; Animals; Corpus Striatum; Cycloleucine; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hydroxyl Radical; Male; Methoxyhydroxyphenylglycol; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Time Factors | 2003 |
Glutamate-mediated cytosolic calcium oscillations regulate a pulsatile prostaglandin release from cultured rat astrocytes.
Topics: Animals; Astrocytes; Calcium; Calcium Signaling; Cell Line; Cells, Cultured; Coculture Techniques; Cycloleucine; Cytosol; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Dinoprostone; Epithelial Cells; Glutamic Acid; Green Fluorescent Proteins; Humans; Indomethacin; Luminescent Proteins; Microscopy, Confocal; Microscopy, Fluorescence; Patch-Clamp Techniques; Prostaglandins; Quisqualic Acid; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Transfection; Valine; Xanthones | 2003 |
Activation of metabotropic glutamate receptors inhibits high-voltage-gated calcium channel currents of chicken nucleus magnocellularis neurons.
Topics: Animals; Barium; Calcium Channel Blockers; Calcium Channels; Chick Embryo; Cochlear Nucleus; Cycloleucine; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Glutamic Acid; In Vitro Techniques; Membrane Potentials; Neural Inhibition; Neurons; Patch-Clamp Techniques; Receptors, Metabotropic Glutamate | 2005 |
Immunocytochemical and pharmacological characterization of metabotropic glutamate receptors of the vestibular end organs in the frog.
Topics: Animals; Blotting, Western; Brain; Cycloleucine; Electrophysiology; Glutamic Acid; Glycine; Hair Cells, Auditory; Immunohistochemistry; Neurons, Afferent; Neuroprotective Agents; Neurotransmitter Agents; Rana temporaria; Rats; Receptors, Metabotropic Glutamate; Semicircular Canals; Vestibular Nerve | 2005 |
Contribution of spinal glutamatergic receptors to the antinociception caused by agmatine in mice.
Topics: Agmatine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analgesics; Animals; Cycloleucine; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Kainic Acid; Male; Mice; N-Methylaspartate; Neuroprotective Agents; Nociceptors; Pain; Receptors, Glutamate; Spinal Cord | 2006 |
The role of defensins in the excitability of the peripheral vestibular system in the frog: evidence for the presence of communication between the immune and nervous systems.
Topics: Acetylcholine; Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; alpha-Defensins; Animals; Atropine; Cholinergic Antagonists; Cycloleucine; Defensins; Dose-Response Relationship, Drug; Glutamic Acid; Humans; Immune System; In Vitro Techniques; Inflammation; Kainic Acid; N-Methylaspartate; Naloxone; Narcotic Antagonists; Neuroimmunomodulation; Neurons, Afferent; Rabbits; Rana temporaria; Receptors, Cholinergic; Receptors, Glutamate; Receptors, Opioid; Semicircular Canals; Synaptic Transmission; Vestibule, Labyrinth | 2007 |
Glutamate and its metabotropic receptor in Drosophila clock neuron circuits.
Topics: Animals; Animals, Genetically Modified; Behavior, Animal; Brain; Calcium; Cycloleucine; Dose-Response Relationship, Drug; Drosophila; Drosophila Proteins; Gene Expression Regulation; Glutamic Acid; Larva; Motor Activity; Nerve Net; Neurons; Neuroprotective Agents; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2007 |
Effect of exogenous glutamate and N-Methyl-D-aspartic acid on spontaneous activity of isolated human ureter.
Topics: Adult; Aged; Cycloleucine; Female; Glutamic Acid; Humans; In Vitro Techniques; Kainic Acid; Male; Middle Aged; Muscle, Smooth; N-Methylaspartate; Ureter | 2007 |
The glutamate uptake system in presynaptic vesicles: further characterization of structural requirements for inhibitors and substrates.
Topics: Animals; Cattle; Cycloleucine; Glutamic Acid; Models, Molecular; Protein Conformation; Receptors, Glutamate; Synaptic Vesicles | 2008 |
Evaluation of cannabinoid receptor 2 and metabotropic glutamate receptor 1 functional responses using a cell impedance-based technology.
Topics: Analgesics; Animals; Benzimidazoles; Biological Assay; Calcium; Cannabinoids; CHO Cells; Chromones; Cricetinae; Cricetulus; Cyclic AMP; Cyclohexanols; Cycloleucine; Electric Impedance; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Indoles; Naphthalenes; Neuroprotective Agents; Quinolines; Quisqualic Acid; Receptor, Cannabinoid, CB2; Receptors, Metabotropic Glutamate; Resorcinols; Signal Transduction; Thiazoles | 2010 |
[The protective effect of puerarin on cultured rat cerebral cortical astrocytes].
Topics: Animals; Astrocytes; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Cycloleucine; Drug Antagonism; Glucose; Glutamic Acid; Isoflavones; Neuroprotective Agents; Rats; Rats, Wistar | 2001 |
Quantal amplitude at the cone ribbon synapse can be adjusted by changes in cytosolic glutamate.
Topics: Ambystoma; Animals; Cycloleucine; Cytosol; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Exocytosis; Glutamic Acid; Macrolides; Receptors, Glutamate; Retinal Cone Photoreceptor Cells; Stochastic Processes; Synapses; Synaptic Transmission; Synaptic Vesicles; Vision, Ocular | 2011 |