glucose, (beta-d)-isomer has been researched along with secoisolariciresinol diglucoside in 149 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (6.71) | 18.2507 |
| 2000's | 50 (33.56) | 29.6817 |
| 2010's | 67 (44.97) | 24.3611 |
| 2020's | 22 (14.77) | 2.80 |
| Authors | Studies |
|---|---|
| Bambagiotti-Alberti, M; Coron, SA; Ghiara, C; Moreti, G; Raffaelli, A | 1 |
| Bambagiotti-Alberti, M; Coran, SA; Ghiara, C; Giannellini, V; Raffaelli, A | 1 |
| Jenab, M; Thompson, LU | 1 |
| Orcheson, LJ; Rickard, SE; Seidl, MM; Thompson, LU | 1 |
| Prasad, K | 6 |
| Rickard, SE; Thompson, LU | 2 |
| Li, D; Thompson, LU; Yan, L; Yee, JA | 1 |
| Chen, J; Rickard, SE; Thompson, LU; Yuan, YV | 1 |
| Kitts, DD; Thompson, LU; Wijewickreme, AN; Yuan, YV | 1 |
| Mantha, SV; Muir, AD; Prasad, K; Westcott, ND | 1 |
| Rickard, SE; Thompson, LU; Yuan, YV | 1 |
| Hattori, M; Li, Y; Meselhy, MR; Qin, GW; Wang, LQ | 1 |
| Aman, P; Johnsson, P; Kamal-Eldin, A; Lundgren, LN | 1 |
| Jiang, FO; Thompson, LU; Ward, WE | 1 |
| Aman, P; Andersson, R; Andersson, RE; Johnsson, P; Kamal-Eldin, A; Lundgren, LN; Peerlkamp, N | 1 |
| Davin, LB; Ford, JD; Huang, KS; Lewis, NG; Wang, HB | 1 |
| Degenhardt, A; Habben, S; Winterhalter, P | 1 |
| Angoelal, R; Dachtler, M; Fritsche, J | 1 |
| Chen, J; Tan, KP; Thompson, LU; Ward, WE | 1 |
| Ijiri, Y; Oda, E; Sano, T; Shiramasa, H; Yamamoto, J; Yamashita, T | 1 |
| Aman, P; Budek, A; Eliasson, C; Frank, J; Kamal-Eldin, A; Leroy-Nivard, D; Lundh, T; Vessby, B | 1 |
| Arts, IC; Hollman, PC; Kuijsten, A; Vree, TB | 1 |
| Chen, J; Thompson, LU; Wang, L | 1 |
| Alpert, CA; Blaut, M; Clavel, T; Doré, J; Henderson, G; Philippe, C; Rigottier-Gois, L | 1 |
| Bügel, S; Hallund, J; Ravn-Haren, G; Tetens, I; Tholstrup, T | 1 |
| Hietaniemi, V; Hiidenhovi, JA; Hyvärinen, HK; Korhonen, HJ; Pihlava, JM; Ryhänen, EL | 2 |
| Blaut, M; Clavel, T; Doré, J; Engst, W; Henderson, G | 1 |
| Knust, U; Owen, RW; Spiegelhalder, B; Strowitzki, T | 1 |
| Liu, Z; Saarinen, NM; Thompson, LU | 1 |
| Blaut, M; Borrmann, D; Braune, A; Clavel, T; Doré, J | 1 |
| Lee, P; Prasad, K | 1 |
| Koneru, S; Maulik, N; Penumathsa, SV; Prasad, K; Thirunavukkarasu, M; Zhan, L | 1 |
| Blaut, M; Clavel, T; Doré, J; Gavini, F; Lippman, R | 1 |
| Hosseinian, FS; Krol, ES; Muir, AD; Westcott, ND | 1 |
| Aukema, H; Bankovic-Calic, N; Kovacs, H; Nitschmann, E; Ogborn, M; Weiler, HA | 1 |
| Xu, S; Zhang, W | 1 |
| Hu, C; Kitts, DD; Yuan, YV | 1 |
| Hu, XY; Kong, F; Liu, XX; Sun, DX; Wang, XL; Zhang, LY | 1 |
| Akao, T; Hattori, M; Jin, JS; Kakiuchi, N; Min, BS; Nakamura, N; Zhao, YF | 1 |
| John, S; Koneru, S; Maulik, N; Menon, VP; Penumathsa, SV; Prasad, K; Zhan, L | 1 |
| Empie, MW; Flickinger, B; Liu, Y; Sun, SZ; Tian, H; Wang, X; Zhang, W | 2 |
| Aida, K; Fukumitsu, S; Kobori, M; Ozawa, S; Takahashi, Y; Ueno, N | 1 |
| Li, X; Liu, X; Wang, JH; Xu, SP; Yuan, JP | 2 |
| Eeckhaut, E; Keukeleire, DD; Possemiers, S; Struijs, K; Verstraete, W; Vincken, JP | 1 |
| Galbreath, CW; Lardy, GP; Odde, KG; Scholljegerdes, EJ; Schroeder, JW; Vonnahme, KA; Wilson, ME | 1 |
| Bambagiotti-Alberti, M; Bartolucci, G; Coran, SA | 1 |
| Hall, C; Kubátová, A; Popova, IE | 1 |
| Alcorn, J; Felmlee, MA; Krol, ES; Muir, AD; Simko, E; Woo, G | 1 |
| Cao, R; Cui, S; Gagnon, N; Mir, PS; Petit, HV | 1 |
| Hattori, M; Jin, JS | 1 |
| Chen, J; Corey, P; Saggar, JK; Thompson, LU | 3 |
| Adolphe, JL; Alcorn, J; Juurlink, BH; Thorpe, LU; Whiting, SJ | 1 |
| Beta, T; Hosseinian, FS | 1 |
| Ayella, A; Iwamoto, T; Jiang, Y; Lim, S; Lin, D; Tomich, J; Wang, W | 1 |
| Britten, M; Côrtes, C; Gagnon, N; Giroux, HJ; Matumoto-Pintro, PT; Petit, HV | 1 |
| Amaretti, A; Leonardi, A; Raimondi, S; Roncaglia, L; Rossi, M | 1 |
| Aliev, OI; Anishchenko, AM; Plotnikova, TM; Vasil'eva, NV | 1 |
| Chen, JM; Thompson, LU; Truan, JS | 1 |
| Park, JB; Velasquez, MT | 1 |
| Li, XW; Yang, JR | 1 |
| Klaes, M; Schmidt, TJ; Sendker, J | 1 |
| Cai, SQ; Ku, BS; Li, MX; Liu, GR; Liu, SL; Ma, XQ; Wang, CZ; Yang, DH; Zhu, HY | 1 |
| Bôer, CG; Bracht, A; Colli, MC; de Oliveira, AL; de Souza, CG; Peralta, RM; Soares, AA | 1 |
| Debouche, C; During, A; Larondelle, Y; Raas, T | 1 |
| Arguiri, E; Cengel, KA; Christofidou-Solomidou, M; Dukes, F; Grieshaber, PA; Pietrofesa, R; Solomides, CC; Turowski, J; Tyagi, S | 1 |
| Moree, SS; Rajesha, J | 1 |
| Kavishankar, GB; Moree, SS; Rajesha, J | 1 |
| Arguiri, E; Busch, TM; Cengel, KA; Christofidou-Solomidou, M; Dukes, F; Gallagher-Colombo, SM; Pietrofesa, R; Solomides, CC; Turowski, J; Tyagi, S | 1 |
| Cai, SQ; Liu, SL; Tao, YL; Wang, YS; Wang, ZQ; Yang, DH; Zhang, Y; Zhang, YT | 1 |
| Christofidou-Solomidou, M; Heretsch, P; Mishra, OP; Nicolaou, KC; Pietrofesa, R; Shuvaev, VV; Simmons, N; Tyagi, S; Valiulin, RA | 1 |
| Balneaves, LG; Cooley, K; Fergusson, D; Fernandes, R; Flower, G; Fritz, H; Kennedy, D; Sagar, S; Seely, D; Skidmore, B; Verma, S; Wong, R | 1 |
| Bastías, JM; Estévez, AM; Figuerola, F; Fuentealba, C; Muñoz, O | 1 |
| Alcorn, J; Krol, ES; Michel, D; Muir, AD; Mukker, JK | 1 |
| Bodhankar, SL; Hegde, MV; Rajamohanan, PR; Rojatkar, SR; Sonawane, KB; Zanwar, AA | 1 |
| Cloutier, SJ; Datla, R; Deyholos, M; Fofana, B; Ghose, K; Kirby, CW; McCallum, J; Selvaraj, K; Sweeney-Nixon, M | 1 |
| Christofidou-Solomidou, M; Mishra, OP; Pietrofesa, R | 1 |
| Sherif, IO | 1 |
| Chaudhary, J; Simons, R; Sonawane, N; Verbruggen, M | 1 |
| Alcorn, J; Krol, ES; Muir, AD; Mukker, JK; Singh, RS | 1 |
| Aliani, M; Aukema, HM; Austria, JA; Dibrov, E; Edel, AL; Patenaude, AF; Pierce, GN; Richard, MN | 1 |
| Abdel-Malak, J; Agostino, A; Belló-Klein, A; Bryan, S; Gurney, C; Khaper, N; Laakso, A; Prasad, K; Puukila, S | 1 |
| Bowen, BP; Dalisay, DS; Davin, LB; Kim, KW; Lee, C; Lewis, NG; Rübel, O; Yang, H | 1 |
| Delman, DM; Fabian, CJ; Kimler, BF; Petroff, BK; Yeh, H | 1 |
| Li, WY; Li, ZM; Tian, H; Wang, JW; Xiao, D | 1 |
| Ahmad, N; Anjum, FM; Hussain, S; Imran, M; Khan, MK; Mushtaq, Z; Nadeem, M | 1 |
| Li, FF; Tan, ZJ; Wang, CY; Wang, HY; Yang, ZZ; Yi, YJ; Zhou, WL | 1 |
| Jadhav, A; Prasad, K | 1 |
| Albelda, SM; Arguiri, E; Christofidou-Solomidou, M; Hwang, WT; Menges, CW; Pietrofesa, RA; Testa, JR; Velalopoulou, A | 1 |
| Arguiri, E; Christofidou-Solomidou, M; Pietrofesa, RA; Tyagi, S; Velalopoulou, A | 1 |
| Amaretti, A; García-Villalba, R; Leonardi, A; Quartieri, A; Raimondi, S; Rossi, M; Tomàs-Barberàn, F | 1 |
| Albelda, SM; Christofidou-Solomidou, M; Pietrofesa, RA; Velalopoulou, A | 1 |
| Christofidou-Solomidou, M; Mishra, OP; Pietrofesa, RA; Popov, AV | 1 |
| Patel, BM; Shah, NR | 1 |
| Chen, G; Fu, X; Guo, X; Li, T; Liu, RH; Qiu, C; Wang, H; Wang, J; Wang, Y; Ye, Y | 1 |
| Demailly, H; Fliniaux, O; Grand, E; Hano, C; Kovensky, J; Mesnard, F; Molinié, R; Paetz, C; Quéro, A; Ramsay, A; Roscher, A; Schneider, B | 1 |
| Chen, CY; Chen, LH; Chen, WG; Huang, Y; Qin, LQ; Ren, GY | 1 |
| Boonen, R; Liu, J; Olivia, CM; Reaney, MJ; Shen, J; Shim, YY | 1 |
| Cloutier, S; Fofana, B; Ghose, K; McCallum, J; You, FM | 1 |
| Belló-Klein, A; Bonetto, JHP; Boreham, D; Carraro, CC; da Rosa Araujo, AS; de Lima-Seolin, BG; Fernandes, RO; Khaper, N; Puukila, S; Türck, P | 1 |
| Güllich, A; Manfredini, V; Oliveira, P; Piccoli, J; Pilar, B; Ströher, D | 1 |
| Abdel-Rahim, EA; El-Bahr, MK; Gabr, AMM; Mabrok, HB; Smetanska, I | 1 |
| Berman, A; Chatterjee, S; Christofidou-Solomidou, M; Koumenis, C; Koziol-White, C; Lin, L; Panettieri, RA; Pietrofesa, RA; Tuttle, S; Velalopoulou, A | 1 |
| Jin, JS; Jung, Y; Kang, J; Kim, HL; Kwak, HJ; Lim, S; Park, H; Park, J; Song, G; Um, JY; Youn, DH | 1 |
| Bergholz, T; Conde Lima, LG; Eklund, B; Hall, C; Shah, M | 1 |
| Christofidou-Solomidou, M; Erickson, MA; Gajghate, S; Jordan-Sciutto, KL; Persidsky, Y; Reichenbach, NL; Rom, S; Winfield, M; Zuluaga-Ramirez, V | 1 |
| Andrake, M; Christofidou-Solomidou, M; Mishra, OP; Nakamaru-Ogiso, E; Pietrofesa, RA; Popov, AV | 1 |
| Deng, B; Hua, Y; Huang, G; Huang, X; Jin, W; Liu, B; Liu, M; Tan, Z; Wu, Y; Yan, W; Zhou, Y | 1 |
| Abbasi, BH; Ahmad, W; Giglioli-Guivarc'h, N; Hano, C; Nadeem, M; Zahir, A | 1 |
| Bowers, LW; Camp, KK; Fabian, CJ; Ford, NA; Hursting, SD; Kimler, BK; Lineberger, CG; Punjala, A; Rossi, EL | 1 |
| Christofidou-Solomidou, M; Drosatos, K; Hoffman, M; Kalliora, C; Koch, WJ; Kokkinaki, D; Kyriazis, ID; Lucchese, AM; Lymperopoulos, A; Madesh, M; Maning, J; Park, JY; Shanmughapriya, S; Tomar, D; Wang, H; Yang, XF | 1 |
| Berman, AT; Carabe-Fernandez, A; Chatterjee, S; Christofidou-Solomidou, M; Koumenis, C; Park, K; Pietrofesa, RA; Sielecki, T; Tao, JQ | 1 |
| Albelda, SM; Christofidou-Solomidou, M; Keil, DE; Park, K; Pfau, JC; Pietrofesa, RA; Serve, KM | 1 |
| Bergaentzlé, M; Flieller, A; Marchioni, E; Zhao, M | 1 |
| Aliani, M; Austria, JA; Maddaford, TG; Netticadan, T; Parikh, M; Pierce, GN | 1 |
| Austria, JA; Garg, B; Netticadan, T; Parikh, M; Pierce, GN; Raj, P; Yu, L | 1 |
| Chen, P; Cheng, C; Deng, Q; Huang, Q; McClements, DJ; Tang, H; Wang, X; Xiang, X; Yu, K; Yu, X | 1 |
| Capitanio, JP; Christofidou-Solomidou, M; Flayer, CH; Haczku, A; Joseph, A; Kao, S; Larson, ED; Miller, LA; Qu, W; Royer, CM; Sielecki, T; Van Haren, A | 1 |
| Bao, T; Chen, H; Chen, T; He, F; Rong, S; Wang, Z; Yang, C; Yang, S; Yang, X; Zhang, Y; Zhu, L | 1 |
| Chalise, P; Dooley, WC; Fabian, CJ; Garber, JE; Hu, J; Hursting, SD; Jernigan, C; Khan, SA; Kimler, BF; Klemp, JR; Koestler, DC; Kreutzjans, AL; Metheny, T; Nydegger, JL; Petroff, BK; Phillips, TA; Powers, KR; Yee, LD; Yellapu, NK; Zalles, CM | 1 |
| Dong, S; Ji, B; Liu, X; Liu, Z; Wang, Y; Wei, L; Yao, S; Zhao, B; Zhao, C | 1 |
| Ahn, KS; Cho, SY; Jiao, W; Jung, Y; Kang, J; Kim, WY; Kwak, HJ; Lee, S; Park, J; Park, JY; Park, WY; Song, G; Um, JY; Youn, DH | 1 |
| Chen, JN; Lu, M; Luo, HR; Tan, L; Wu, GS; Yang, ZL; Zhou, XG; Zhu, Q | 1 |
| Dibrov, E; Kura, B; Netticadan, T; O'Hara, KA; Parikh, M; Pierce, GN; Slezak, J | 1 |
| Andreeva, OE; Mikhaevich, EI; Salnikova, DI; Scherbakov, AM; Stasevich, OV | 1 |
| Dhaini, J; Haykal, T; Hodroj, MH; Rizk, S; Tannous, S | 1 |
| Bayram, D; Özgöçmen, M; Şahin Calapoğlu, N; Toğay, VA; Yavuz Türel, G | 1 |
| Aho, K; Badger, R; Serve, K | 1 |
| Alcorn, J; Guo, Y; Mustafa, R; Purdy, SK; Reaney, MJT; Shen, J; Tse, TJ; Yang, X | 2 |
| Boesze-Battaglia, K; Christofidou-Solomidou, M; Dhingra, A; Kim, T; Park, K; Pietrofesa, RA; Popov, AV; Sharp, RC; Ying, GS | 1 |
| Comelli, EM; Gargari, G; Guglielmetti, S; Ku, M; Kubant, A; Lepp, D; Lin, Z; Power, KA; Taibi, A; Thompson, LU | 1 |
| Arguiri, E; Chatterjee, S; Christofidou-Solomidou, M; Hwang, WT; Johnson-McDaniel, D; Mishra, OP; Moorthy, GS; Myerson, JW; Park, K; Pietrofesa, RA; Shuvaev, VV; Zuppa, A | 1 |
| Badger, R; Christofidou-Solomidou, M; Park, K; Pietrofesa, RA; Serve, KM | 1 |
| Dou, QP; Ge, J; Hao, R; Li, D; Li, F; Li, G; Rong, X; Tan, X | 1 |
| Han, W; Lan, Y; Li, J; Liu, X; Wang, Y; Yang, Y; Zhang, L | 1 |
| Chen, T; Li, H; Wang, J; Wang, Z; Xu, X; Zhang, D; Zhang, H; Zhang, L; Zhong, J; Zhong, X | 1 |
| Luo, J; Sun, L; Wang, P; Xu, Q; Yu, L; Zhang, L; Zheng, Z; Zhou, J; Zuo, D | 1 |
| Albelda, SM; Chatterjee, S; Christofidou-Solomidou, M; Kadariya, Y; Pietrofesa, RA; Testa, JR | 1 |
7 review(s) available for glucose, (beta-d)-isomer and secoisolariciresinol diglucoside
| Article | Year |
|---|---|
Health effects with consumption of the flax lignan secoisolariciresinol diglucoside.
Topics: Animals; Antioxidants; Butylene Glycols; Cardiovascular Diseases; Diabetes Mellitus; Diet; Enzyme Activators; Enzyme Inhibitors; Female; Flax; Glucosides; Humans; Lignin; Neoplasms; Phytoestrogens; Pregnancy | 2010 |
Patented techniques for the extraction and isolation of secoisolari-ciresinol diglucoside from flaxseed.
Topics: Antioxidants; Butylene Glycols; Chromatography, High Pressure Liquid; Flax; Glucosides; Humans; Lignans; Mass Spectrometry; Patents as Topic | 2009 |
Natural products in regression and slowing of progression of atherosclerosis.
Topics: Animals; Antioxidants; Atherosclerosis; Biological Products; Butylene Glycols; Disease Progression; Flax; Glucosides; Humans; Hypercholesterolemia; Lignans; Oxidative Stress; Phytotherapy; Vitamin E | 2010 |
Flax and Breast Cancer: A Systematic Review.
Topics: Breast Density; Breast Neoplasms; Butylene Glycols; Cell Proliferation; Dietary Supplements; Female; Flax; Glucosides; Hot Flashes; Humans; Menopause | 2014 |
Potential protective properties of flax lignan secoisolariciresinol diglucoside.
Topics: Animals; Antioxidants; Butylene Glycols; Chemoprevention; Disease Models, Animal; Flax; Glucosides; Humans; Lignans; Phytochemicals; Plant Extracts | 2015 |
Prevention and treatment of atherosclerosis with flaxseed-derived compound secoisolariciresinol diglucoside.
Topics: Animals; Butylene Glycols; Coronary Artery Disease; Disease Models, Animal; Flax; Glucosides; Humans; Phytotherapy; Rabbits | 2016 |
Dietary Flaxseed as a Strategy for Improving Human Health.
Topics: alpha-Linolenic Acid; Animals; Anti-Inflammatory Agents; Antioxidants; Brain; Butylene Glycols; Cardiovascular Diseases; Diet; Dietary Fiber; Dietary Supplements; Fatty Acids, Omega-3; Female; Flax; Functional Food; Gastrointestinal Diseases; Glucosides; Hormones; Humans; Lignans; Lipid Metabolism; Neoplasms; Seeds | 2019 |
8 trial(s) available for glucose, (beta-d)-isomer and secoisolariciresinol diglucoside
| Article | Year |
|---|---|
A lignan complex isolated from flaxseed does not affect plasma lipid concentrations or antioxidant capacity in healthy postmenopausal women.
Topics: 4-Butyrolactone; Butylene Glycols; Cross-Over Studies; Denmark; Double-Blind Method; Female; Flax; Glucosides; Humans; Lignans; Lipids; Middle Aged; Postmenopause | 2006 |
Contribution of linseed intake to urine and serum enterolignan levels in German females: a randomised controlled intervention trial.
Topics: Adult; Butylene Glycols; Chromatography, High Pressure Liquid; Diet; Dietary Supplements; Female; Fruit; Germany; Glucosides; Humans; Lignans; Linseed Oil; Middle Aged; Spectrometry, Mass, Electrospray Ionization; Vegetables | 2006 |
Dietary flaxseed lignan extract lowers plasma cholesterol and glucose concentrations in hypercholesterolaemic subjects.
Topics: Adult; Alanine Transaminase; Blood Glucose; Butylene Glycols; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Creatinine; Dietary Fiber; Double-Blind Method; Female; Flax; gamma-Glutamyltransferase; Glucosides; Humans; Hypercholesterolemia; Linear Models; Male; Middle Aged; Nitrogen; Plant Extracts; Triglycerides; Urea | 2008 |
Effects of dietary flaxseed lignan extract on symptoms of benign prostatic hyperplasia.
Topics: Aged; Aged, 80 and over; Butylene Glycols; Diet; Double-Blind Method; Flax; Glucosides; Humans; Lignans; Male; Middle Aged; Phytotherapy; Placebos; Plant Extracts; Prostatic Hyperplasia; Quality of Life; Urinary Tract; Urination; Urine | 2008 |
Evaluation of the efficacy of flaxseed meal and flaxseed extract in reducing menopausal symptoms.
Topics: Aged; Brazil; Butylene Glycols; Dietary Supplements; Endometrium; Epithelial Cells; Estradiol; Female; Flax; Follicle Stimulating Hormone, Human; Glucosides; Hot Flashes; Humans; Hypertrophy; Menopause; Middle Aged; Phytoestrogens; Plant Extracts; Seeds; Severity of Illness Index; Ultrasonography; Vagina | 2012 |
Efficacy and safety of a flaxseed hull extract in the symptomatic management of benign prostatic hyperplasia: a parallel, randomized, double-blind, placebo-controlled, pilot study.
Topics: Aged; Butylene Glycols; Double-Blind Method; Flax; Glucosides; Humans; India; Male; Middle Aged; Phytotherapy; Pilot Projects; Placebo Effect; Plant Extracts; Polysaccharides; Prostatic Hyperplasia; Quality of Life; Seeds; Treatment Outcome | 2015 |
The effect of flaxseed dose on circulating concentrations of alpha-linolenic acid and secoisolariciresinol diglucoside derived enterolignans in young, healthy adults.
Topics: Adolescent; Adult; alpha-Linolenic Acid; Butylene Glycols; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diet; Docosahexaenoic Acids; Eicosapentaenoic Acid; Fatty Acids, Omega-3; Fatty Acids, Unsaturated; Female; Flax; Glucosides; Humans; Male; Middle Aged; Plant Preparations; Platelet Aggregation; Seeds; Thromboxane B2; Triglycerides; Young Adult | 2016 |
Randomized Phase IIB Trial of the Lignan Secoisolariciresinol Diglucoside in Premenopausal Women at Increased Risk for Development of Breast Cancer.
Topics: Adult; Breast Neoplasms; Butylene Glycols; Female; Flax; Follow-Up Studies; Glucosides; Humans; Hyperplasia; Lignans; Middle Aged; Pilot Projects; Premenopause; Prognosis; Risk Factors; Young Adult | 2020 |
134 other study(ies) available for glucose, (beta-d)-isomer and secoisolariciresinol diglucoside
| Article | Year |
|---|---|
Investigation of mammalian lignan precursors in flax seed: first evidence of secoisolariciresinol diglucoside in two isomeric forms by liquid chromatograph/mass spectrometry.
Topics: Butylene Glycols; Chromatography, High Pressure Liquid; Glucosides; Isomerism; Lignans; Seeds; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Ultraviolet | 1994 |
Revealing the mammalian lignan precursor secoisolariciresinol diglucoside in flax seed by ionspray mass spectrometry.
Topics: Butylene Glycols; Glucosides; Lignans; Mass Spectrometry; Molecular Weight; Plant Extracts; Seeds | 1994 |
The influence of flaxseed and lignans on colon carcinogenesis and beta-glucuronidase activity.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Butylene Glycols; Cecum; Colonic Neoplasms; Eating; Fatty Acids; Glucosides; Glucuronidase; Hydrogen-Ion Concentration; Lignans; Male; Organ Size; Plant Extracts; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Seeds | 1996 |
Flaxseed and its lignan and oil components reduce mammary tumor growth at a late stage of carcinogenesis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Butylene Glycols; Carcinogens; Cell Division; Female; Glucosides; Lignans; Mammary Neoplasms, Experimental; Rats; Rats, Sprague-Dawley; Seeds | 1996 |
Hydroxyl radical-scavenging property of secoisolariciresinol diglucoside (SDG) isolated from flax-seed.
Topics: Butylene Glycols; Chromatography, High Pressure Liquid; Free Radical Scavengers; Gentisates; Glucosides; Hydroxybenzoates; Hydroxyl Radical; Lipid Peroxidation; Seeds; Sensitivity and Specificity; Ultraviolet Rays | 1997 |
Chronic exposure to secoisolariciresinol diglycoside alters lignan disposition in rats.
Topics: Animals; Blood; Butylene Glycols; Feces; Female; Gastrointestinal Contents; Glucosides; Lignans; Rats; Rats, Sprague-Dawley; Time Factors; Tissue Distribution | 1998 |
Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed.
Topics: Animals; Aortic Diseases; Arteriosclerosis; Body Weight; Butylene Glycols; Cholesterol; Cholesterol, LDL; Diet, Atherogenic; Glucosides; Hypercholesterolemia; Lipid Peroxidation; Lipoproteins; Luminescent Measurements; Malondialdehyde; Rabbits; Seeds; Triglycerides | 1999 |
Dietary supplementation with secoisolariciresinol diglycoside (SDG) reduces experimental metastasis of melanoma cells in mice.
Topics: Animals; Butylene Glycols; Diet; Dose-Response Relationship, Drug; Glucosides; Melanoma; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Skin Neoplasms | 1999 |
Dose effects of flaxseed and its lignan on N-methyl-N-nitrosourea-induced mammary tumorigenesis in rats.
Topics: Adenocarcinoma; Animals; Butylene Glycols; Carcinogens; Diet; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Flax; Glucosides; Lignans; Mammary Neoplasms, Experimental; Methylnitrosourea; Phytotherapy; Random Allocation; Rats; Rats, Sprague-Dawley | 1999 |
Antioxidant activity of the flaxseed lignan secoisolariciresinol diglycoside and its mammalian lignan metabolites enterodiol and enterolactone.
Topics: 4-Butyrolactone; Animals; Antioxidants; Butylene Glycols; Emulsions; Estrogens; Flax; Free Radical Scavengers; Glucosides; Hydroxides; Lignans; Linoleic Acid; Lipid Peroxidation; Mammals; Oxidation-Reduction; Seeds | 1999 |
Protective effect of secoisolariciresinol diglucoside against streptozotocin-induced diabetes and its mechanism.
Topics: Animals; Antioxidants; Blood Glucose; Butylene Glycols; Diabetes Mellitus, Experimental; Glucose; Glucosides; Leukocytes; Lipid Peroxidation; Luminescent Measurements; Male; Malondialdehyde; Oxidative Stress; Pancreas; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Thiobarbituric Acid Reactive Substances | 2000 |
Oxidative stress as a mechanism of diabetes in diabetic BB prone rats: effect of secoisolariciresinol diglucoside (SDG).
Topics: Animals; Butylene Glycols; Diabetes Mellitus, Type 1; Glucosides; Glycosuria; Humans; Hyperglycemia; Lipid Peroxidation; Malondialdehyde; Oxidative Stress; Pancreas; Rats; Rats, Inbred BB; Reactive Oxygen Species | 2000 |
Urinary composition and postprandial blood changes in H-secoisolariciresinol diglycoside (SDG) metabolites in rats do not differ between acute and chronic SDG treatments.
Topics: Analysis of Variance; Animals; Butylene Glycols; Chromatography, High Pressure Liquid; Female; Gas Chromatography-Mass Spectrometry; Glucosides; Lignans; Postprandial Period; Rats; Rats, Sprague-Dawley | 2000 |
Plasma insulin-like growth factor I levels in rats are reduced by dietary supplementation of flaxseed or its lignan secoisolariciresinol diglycoside.
Topics: Animals; Anticarcinogenic Agents; Body Weight; Butylene Glycols; Carcinogens; Dietary Supplements; Eating; Female; Flax; Glucosides; Insulin-Like Growth Factor I; Lignans; Mammary Glands, Animal; Methylnitrosourea; Organ Size; Rats; Rats, Sprague-Dawley | 2000 |
Human intestinal bacteria capable of transforming secoisolariciresinol diglucoside to mammalian lignans, enterodiol and enterolactone.
Topics: 4-Butyrolactone; Animals; Butylene Glycols; Culture Media; Estrogens; Eubacterium; Feces; Glucosides; Humans; Intestines; Lignans; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Peptostreptococcus; Rats; Rats, Wistar | 2000 |
HPLC method for analysis of secoisolariciresinol diglucoside in flaxseeds.
Topics: Butylene Glycols; Chromatography, High Pressure Liquid; Denmark; Flax; Flour; Glucosides; Indicators and Reagents; Seeds; Sweden | 2000 |
Exposure to flaxseed or purified lignan during lactation influences rat mammary gland structures.
Topics: Analysis of Variance; Animals; Anticarcinogenic Agents; Butylene Glycols; Female; Flax; Glucosides; Lactation; Lignans; Mammary Glands, Animal; Mammary Neoplasms, Animal; Pregnancy; Random Allocation; Rats | 2000 |
Secoisolariciresinol diglucoside from flaxseed delays the development of type 2 diabetes in Zucker rat.
Topics: Animals; Antioxidants; Blood Glucose; Butylene Glycols; Cholesterol; Diabetes Mellitus, Type 2; Disease Models, Animal; Female; Flax; Glucosides; Glycated Hemoglobin; Malondialdehyde; Oxidative Stress; Rats; Rats, Zucker; Triglycerides | 2001 |
An oligomer from flaxseed composed of secoisolariciresinoldiglucoside and 3-hydroxy-3-methyl glutaric acid residues.
Topics: Butylene Glycols; Carbohydrate Conformation; Carbohydrate Sequence; Flax; Glucosides; Magnetic Resonance Spectroscopy; Meglutol | 2001 |
Biosynthetic pathway to the cancer chemopreventive secoisolariciresinol diglucoside-hydroxymethyl glutaryl ester-linked lignan oligomers in flax (Linum usitatissimum) seed.
Topics: Benzimidazoles; Butylene Glycols; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Flax; Gas Chromatography-Mass Spectrometry; Glucosides; Lignans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phenylalanine; Phenylpropionates; Plants, Medicinal; Polymers; Seeds; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Stereoisomerism; Tetrazoles | 2001 |
Isolation of the lignan secoisolariciresinol diglucoside from flaxseed (Linum usitatissimum L.) by high-speed counter-current chromatography.
Topics: Butylene Glycols; Chromatography, High Pressure Liquid; Countercurrent Distribution; Flax; Glucosides; Magnetic Resonance Spectroscopy; Mass Spectrometry | 2002 |
On-line liquid-chromatography-nuclear magnetic resonance spectroscopy-mass spectrometry coupling for the separation and characterization of secoisolariciresinol diglucoside isomers in flaxseed.
Topics: Butylene Glycols; Circular Dichroism; Flax; Glucosides; Isomerism; Magnetic Resonance Spectroscopy; Mass Spectrometry | 2002 |
Exposure to flaxseed or its purified lignan during suckling inhibits chemically induced rat mammary tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Animals, Suckling; Body Weight; Butylene Glycols; Carcinogens; Diet; Disease Models, Animal; Female; Flax; Glucosides; Lactation; Lignans; Mammary Neoplasms, Experimental; Rats; Rats, Sprague-Dawley; Reproduction | 2003 |
Antithrombic and anti-atherogenic effects of partially defatted flaxseed meal using a laser-induced thrombosis test in apolipoprotein E and low-density lipoprotein receptor deficient mice.
Topics: Animals; Arteriosclerosis; Butylene Glycols; Diet; Disease Models, Animal; Flax; Glucosides; Lasers; Male; Mice; Mice, Inbred C57BL; Phytotherapy; Thrombosis | 2003 |
Dietary secoisolariciresinol diglucoside and its oligomers with 3-hydroxy-3-methyl glutaric acid decrease vitamin E levels in rats.
Topics: Animals; Anticholesteremic Agents; Antioxidants; Butylene Glycols; Cholesterol; Chromatography, High Pressure Liquid; Coumaric Acids; Diet; Flax; Free Radical Scavengers; Glucosides; Liver; Meglutol; Propionates; Rats; Rats, Sprague-Dawley; Seeds; Tocopherols; Vitamin E | 2004 |
Pharmacokinetics of enterolignans in healthy men and women consuming a single dose of secoisolariciresinol diglucoside.
Topics: 4-Butyrolactone; Adult; Blood Specimen Collection; Butylene Glycols; Dietary Supplements; Female; Glucosides; Humans; Lignans; Male; Reference Values | 2005 |
Flaxseed and its components reduce metastasis after surgical excision of solid human breast tumor in nude mice.
Topics: Animals; Butylene Glycols; Cell Line, Tumor; Female; Glucosides; Humans; Linseed Oil; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation | 2006 |
Intestinal bacterial communities that produce active estrogen-like compounds enterodiol and enterolactone in humans.
Topics: 4-Butyrolactone; Actinobacteria; Adult; Bacteria, Anaerobic; Butylene Glycols; Colony Count, Microbial; Culture Media; Female; Flow Cytometry; Glucosides; Humans; In Situ Hybridization, Fluorescence; Intestines; Lignans; Male; Middle Aged; Peptostreptococcus; Phytoestrogens | 2005 |
Effect of processing and storage on the stability of flaxseed lignan added to bakery products.
Topics: Butylene Glycols; Drug Stability; Flax; Food Analysis; Food Handling; Food Preservation; Food, Fortified; Glucosides; Lignans | 2006 |
Phylogeny of human intestinal bacteria that activate the dietary lignan secoisolariciresinol diglucoside.
Topics: 4-Butyrolactone; Bacteria, Anaerobic; Butylene Glycols; Culture Media; Glucosides; Humans; Intestines; Lignans; Phylogeny | 2006 |
Sesamin is one of the major precursors of mammalian lignans in sesame seed (Sesamum indicum) as observed in vitro and in rats.
Topics: Animals; Butylene Glycols; Dioxoles; Feces; Female; Fermentation; Flax; Gas Chromatography-Mass Spectrometry; Glucosides; Humans; Lignans; Mass Spectrometry; Rats; Rats, Sprague-Dawley; Seeds; Sesamum | 2006 |
Occurrence and activity of human intestinal bacteria involved in the conversion of dietary lignans.
Topics: Bacteroides; Butylene Glycols; Clostridium; Diet; Feces; Glucosides; Humans; Intestinal Mucosa; Intestines; Lignans; Species Specificity | 2006 |
Suppression of hypercholesterolemic atherosclerosis by pentoxifylline and its mechanism.
Topics: Animals; Antioxidants; Aorta; Atherosclerosis; Body Weight; Butylene Glycols; Cholesterol, Dietary; Female; Glucosides; Hypercholesterolemia; Lipids; Luminescence; Malondialdehyde; Pentoxifylline; Rabbits | 2007 |
Effect of processing and storage on the stability of flaxseed lignan added to dairy products.
Topics: Butylene Glycols; Dairy Products; Flax; Food Technology; Glucosides; Lignans | 2006 |
Secoisolariciresinol diglucoside: relevance to angiogenesis and cardioprotection against ischemia-reperfusion injury.
Topics: Animals; Apoptosis; Butylene Glycols; Cells, Cultured; Echocardiography; Glucosides; Humans; Male; Morphogenesis; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Neovascularization, Physiologic; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Rats; Rats, Sprague-Dawley | 2007 |
Clostridium saccharogumia sp. nov. and Lactonifactor longoviformis gen. nov., sp. nov., two novel human faecal bacteria involved in the conversion of the dietary phytoestrogen secoisolariciresinol diglucoside.
Topics: 4-Butyrolactone; Adult; Base Composition; Butylene Glycols; Clostridium; Colon; Culture Media; Dietary Carbohydrates; DNA; DNA, Ribosomal; Feces; Genotype; Glucosides; Gram-Positive Rods; Humans; Lignans; Male; Molecular Sequence Data; Nucleic Acid Hybridization; Phenotype; Phylogeny; Phytoestrogens; RNA, Ribosomal, 16S | 2007 |
AAPH-mediated antioxidant reactions of secoisolariciresinol and SDG.
Topics: Amidines; Antioxidants; Butylene Glycols; Flax; Free Radical Scavengers; Glucosides; Lignans; Molecular Conformation; Oxidation-Reduction; Stereoisomerism; Time Factors | 2007 |
Feeding flaxseed oil but not secoisolariciresinol diglucoside results in higher bone mass in healthy rats and rats with kidney disease.
Topics: Animals; Body Weight; Bone Density; Butylene Glycols; Corn Oil; Dietary Fats; Female; Glucosides; Kidney Diseases; Linseed Oil; Male; Random Allocation; Rats; Rats, Inbred Strains | 2007 |
Purification of secoisolariciresinol diglucoside with column chromatography on a sephadex LH-20.
Topics: Butylene Glycols; Chromatography, Gel; Chromatography, High Pressure Liquid; Glucosides; Magnetic Resonance Spectroscopy | 2007 |
Antioxidant activities of the flaxseed lignan secoisolariciresinol diglucoside, its aglycone secoisolariciresinol and the mammalian lignans enterodiol and enterolactone in vitro.
Topics: 4-Butyrolactone; Animals; Biphenyl Compounds; Butylene Glycols; Flax; Free Radical Scavengers; Glucosides; Hydrazines; Lignans; Liposomes; Mammals; Molecular Structure; Picrates; Seeds | 2007 |
Regulation of zinc transporters by dietary flaxseed lignan in human breast cancer xenografts.
Topics: Animals; Breast Neoplasms; Butylene Glycols; Cation Transport Proteins; Cell Line, Tumor; Diet; Female; Flax; Glucosides; Humans; Lignans; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Proteins; RNA, Messenger; Transplantation, Heterologous | 2008 |
Regression of hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed.
Topics: Animals; Aorta; Atherosclerosis; Butylene Glycols; Flax; Glucosides; Hypercholesterolemia; Lipids; Luminescence; Malondialdehyde; Oxidative Stress; Plant Preparations; Rabbits | 2008 |
Enantioselective dehydroxylation of enterodiol and enterolactone precursors by human intestinal bacteria.
Topics: 4-Butyrolactone; Bacteria, Anaerobic; Biotransformation; Butylene Glycols; Eubacterium; Feces; Glucosides; Humans; Hydroxylation; Intestines; Lignans; Molecular Structure; Phylogeny; RNA, Bacterial; RNA, Ribosomal, 16S; Stereoisomerism | 2007 |
Secoisolariciresinol diglucoside induces neovascularization-mediated cardioprotection against ischemia-reperfusion injury in hypercholesterolemic myocardium.
Topics: Animals; Blood Vessels; Blotting, Western; Butylene Glycols; Cardiotonic Agents; Coronary Vessels; Glucosides; Heart Function Tests; Heme Oxygenase-1; Hypercholesterolemia; Lipid Metabolism; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Neovascularization, Physiologic; Nitric Oxide Synthase Type III; Phosphoproteins; Rats; Rats, Sprague-Dawley; Ultrasonography; Vascular Endothelial Growth Factor A | 2008 |
Flaxseed lignan attenuates high-fat diet-induced fat accumulation and induces adiponectin expression in mice.
Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Animals; Butylene Glycols; Cholesterol; Dietary Fats; Flax; Glucosides; Insulin; Leptin; Lignans; Male; Mice; Mice, Inbred C57BL; Obesity; PPAR gamma; RNA, Messenger; Triglycerides | 2008 |
Separation and determination of secoisolariciresinol diglucoside oligomers and their hydrolysates in the flaxseed extract by high-performance liquid chromatography.
Topics: Butylene Glycols; Chromatography, High Pressure Liquid; Flax; Glucosides; Hydrolysis; Seeds | 2008 |
Metabolism of the lignan macromolecule into enterolignans in the gastrointestinal lumen as determined in the simulator of the human intestinal microbial ecosystem.
Topics: Bacteria; Butylene Glycols; Diet; Ecosystem; Estrogens; Gastrointestinal Tract; Glucosides; Humans; Lignans; Macromolecular Substances; Models, Biological | 2008 |
Effect of feeding flax or linseed meal on progesterone clearance rate in ovariectomized ewes.
Topics: Animals; Butylene Glycols; Dietary Fats; Fatty Acids, Omega-3; Female; Flax; Glucosides; Least-Squares Analysis; Ovariectomy; Progesterone; Random Allocation; Seeds; Sheep | 2008 |
Validation of a reversed phase high performance thin layer chromatographic-densitometric method for secoisolariciresinol diglucoside determination in flaxseed.
Topics: Butylene Glycols; Chromatography, Thin Layer; Densitometry; Flax; Glucosides | 2008 |
Hydrolysis kinetics of secoisolariciresinol diglucoside oligomers from flaxseed.
Topics: Butylene Glycols; Flax; Glucosides; Glycosides; Hydrolysis; Kinetics; Seeds | 2008 |
Determination of lignans in flaxseed using liquid chromatography with time-of-flight mass spectrometry.
Topics: Antioxidants; Butylene Glycols; Chemical Fractionation; Chromatography, High Pressure Liquid; Chromatography, Liquid; Flax; Gas Chromatography-Mass Spectrometry; Glucosides; Least-Squares Analysis; Lignans; Mass Spectrometry; Models, Chemical; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Microextraction; Tandem Mass Spectrometry | 2009 |
Effects of the flaxseed lignans secoisolariciresinol diglucoside and its aglycone on serum and hepatic lipids in hyperlipidaemic rats.
Topics: Animals; Base Sequence; Body Weight; Butylene Glycols; Dose-Response Relationship, Drug; Female; Flax; Fructose; Gene Expression; Glucosides; Hyperlipidemias; Lignans; Lipids; Liver; Male; Models, Animal; Molecular Sequence Data; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar | 2009 |
Milk concentration of the mammalian lignan enterolactone, milk production, milk fatty acid profile, and digestibility in dairy cows fed diets containing whole flaxseed or flaxseed meal.
Topics: 4-Butyrolactone; Animals; Butylene Glycols; Cattle; Diet; Digestion; Fatty Acids; Flax; Glucosides; Lactation; Lignans; Male; Milk; Seeds | 2009 |
Further studies on a human intestinal bacterium Ruminococcus sp. END-1 for transformation of plant lignans to mammalian lignans.
Topics: Biotransformation; Butylene Glycols; Furans; Glucosides; Humans; Intestines; Lignans; Molecular Structure; Ruminococcus; Stereoisomerism | 2009 |
Flaxseed and pure secoisolariciresinol diglucoside, but not flaxseed hull, reduce human breast tumor growth (MCF-7) in athymic mice.
Topics: Animal Feed; Animals; Breast Neoplasms; Butylene Glycols; Cell Line, Tumor; Energy Intake; Estradiol; Female; Flax; Glucosides; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Organ Size; Plant Extracts; Receptors, Estrogen; Seeds; Uterus; Weight Gain | 2009 |
Dietary flaxseed lignan or oil combined with tamoxifen treatment affects MCF-7 tumor growth through estrogen receptor- and growth factor-signaling pathways.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biomarkers, Tumor; Breast Neoplasms; Butylene Glycols; Cell Line, Tumor; Cell Proliferation; Female; Flax; Gene Expression Regulation, Neoplastic; Glucosides; Humans; Lignans; Linseed Oil; Mice; Mice, Nude; Phytotherapy; Random Allocation; Receptors, Estrogen; Receptors, Growth Factor; RNA, Messenger; Seeds; Signal Transduction; Tamoxifen; Tumor Burden; Xenograft Model Antitumor Assays | 2010 |
The effect of secoisolariciresinol diglucoside and flaxseed oil, alone and in combination, on MCF-7 tumor growth and signaling pathways.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biomarkers, Tumor; Breast Neoplasms; Butylene Glycols; Female; Gene Expression Regulation, Neoplastic; Glucosides; Humans; Linseed Oil; Mice; Mice, Nude; Phytoestrogens; Phytotherapy; Proto-Oncogene Proteins; Receptors, Estrogen; Receptors, Growth Factor; RNA, Messenger; Signal Transduction; Time Factors; Tumor Burden; Xenograft Model Antitumor Assays | 2010 |
Cytostatic inhibition of cancer cell growth by lignan secoisolariciresinol diglucoside.
Topics: 4-Butyrolactone; Adenocarcinoma; Anticarcinogenic Agents; Butylene Glycols; Cell Cycle; Cell Line, Tumor; Chromatography, High Pressure Liquid; Colonic Neoplasms; Cyclin A; Cytostatic Agents; Dietary Carbohydrates; Dose-Response Relationship, Drug; Glucosides; Glycosides; Humans; Lignans; Mass Spectrometry | 2010 |
Effect of flaxseed lignans added to milk or fed to cows on oxidative degradation of dairy beverages enriched with polyunsaturated fatty acids.
Topics: 4-Butyrolactone; Animals; Antioxidants; Butylene Glycols; Cattle; Diet; Fatty Acids, Unsaturated; Female; Flax; Food, Fortified; Glucosides; Hot Temperature; Lignans; Milk; Oxidation-Reduction; Oxidative Stress; Photochemical Processes | 2011 |
Role of bifidobacteria in the activation of the lignan secoisolariciresinol diglucoside.
Topics: 4-Butyrolactone; Bifidobacterium; Biotransformation; Butylene Glycols; Glucosides; Lignans | 2011 |
[Effects of flaxseed extract on rheological properties of blood in experimental ovariectomy].
Topics: Animals; Blood Viscosity; Butylene Glycols; Erythrocyte Aggregation; Erythrocyte Deformability; Estradiol; Female; Fibrinogen; Flax; Glucosides; Hematocrit; Ovariectomy; Plant Extracts; Plants; Platelet Aggregation; Rats; Rats, Wistar | 2011 |
Comparative effects of sesame seed lignan and flaxseed lignan in reducing the growth of human breast tumors (MCF-7) at high levels of circulating estrogen in athymic mice.
Topics: Animals; Apoptosis; Body Weight; Breast Neoplasms; Butylene Glycols; Cell Line, Tumor; Cell Proliferation; Dioxoles; Eating; Estrogens; Female; Flax; Glucosides; Humans; Lignans; Mice; Mice, Nude; Receptor, ErbB-2; Receptor, IGF Type 1; Receptors, Estrogen; Seeds; Sesamum; Signal Transduction; Vascular Endothelial Growth Factor Receptor-2; Xenograft Model Antitumor Assays | 2012 |
Potential effects of lignan-enriched flaxseed powder on bodyweight, visceral fat, lipid profile, and blood pressure in rats.
Topics: Animals; Blood Pressure; Body Weight; Butylene Glycols; Diet, High-Fat; Dietary Fats; Dietary Sucrose; Flax; Food, Fortified; Fructose; Glucosides; Heart; Intra-Abdominal Fat; Kidney; Leptin; Lipids; Liver; Male; Organ Size; Rats; Rats, Sprague-Dawley; Seeds | 2012 |
[Effects of secoisolariciresinol diglucoside combined with bortezomib on induction of apoptosis in lung cancer cell line A549].
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Boronic Acids; Bortezomib; Butylene Glycols; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Therapy, Combination; Flow Cytometry; Glucosides; Humans; Lung Neoplasms; Protease Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyrazines; Real-Time Polymerase Chain Reaction; RNA, Messenger | 2012 |
Lignans in seeds of Linum species.
Topics: Butylene Glycols; Flax; Glucosides; Hydrolysis; Lignans; Methylene Chloride; Naphthalenes; Seeds | 2012 |
Production of secoisolariciresinol from defatted flaxseed by bacterial biotransformation.
Topics: Adult; Bacteroidaceae; Biotransformation; Butylene Glycols; Chromatography, High Pressure Liquid; Feces; Female; Fermentation; Flax; Glucosides; Humans; Hydrolysis; Lignans; Male; Phylogeny; RNA, Ribosomal, 16S; Young Adult | 2012 |
Among plant lignans, pinoresinol has the strongest antiinflammatory properties in human intestinal Caco-2 cells.
Topics: 4-Butyrolactone; Anti-Inflammatory Agents; Butylene Glycols; Caco-2 Cells; Cell Differentiation; Chemokine CCL2; Chromatography, High Pressure Liquid; Cyclooxygenase 2; Furans; Glucosides; Humans; Interleukin-1beta; Interleukin-6; Interleukin-8; Intestines; Lignans; NF-kappa B; Plant Extracts; Signal Transduction | 2012 |
Radioprotective role in lung of the flaxseed lignan complex enriched in the phenolic secoisolariciresinol diglucoside (SDG).
Topics: Animals; Antioxidants; Butylene Glycols; Dietary Carbohydrates; Eating; Female; Flax; Glucosides; Inflammation; Lignans; Lung; Mice; Mice, Inbred C57BL; Phenols; Radiation Pneumonitis; Radiation-Protective Agents; Survival Analysis; Thorax; Weight Loss | 2012 |
Investigation of in vitro and in vivo antioxidant potential of secoisolariciresinol diglucoside.
Topics: Animals; Biphenyl Compounds; Butylene Glycols; Carbon Tetrachloride; Catalase; Chemical and Drug Induced Liver Injury; Free Radical Scavengers; Free Radicals; Glucosides; Kidney; Lipid Peroxidation; Liver; Malondialdehyde; Oxidation-Reduction; Peroxidase; Picrates; Rats; Rats, Wistar; Superoxide Dismutase | 2013 |
Antidiabetic effect of secoisolariciresinol diglucoside in streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Butylene Glycols; C-Peptide; Diabetes Mellitus, Experimental; Drug Evaluation, Preclinical; Flax; Glucosides; Hypoglycemic Agents; Insulin; Lipid Metabolism; Lipids; Liver; Male; Pancreas; Phytotherapy; Rats; Rats, Wistar | 2013 |
Radiation mitigating properties of the lignan component in flaxseed.
Topics: Animal Feed; Animals; Bronchoalveolar Lavage Fluid; Butylene Glycols; Cytokines; Female; Fibrosis; Flax; Glucosides; Kaplan-Meier Estimate; Lignans; Lung; Lung Injury; Malondialdehyde; Mice; Mice, Inbred C57BL; Neutrophils; Oxygen; Phytotherapy; Radiation Injuries, Experimental; Radiation Pneumonitis; Radiation-Protective Agents; Seeds; Survival Rate; Time Factors; Transforming Growth Factor beta1; Tyrosine | 2013 |
Cloning, expression, and characterization of the β-glucosidase hydrolyzing secoisolariciresinol diglucoside to secoisolariciresinol from Bacteroides uniformis ZL1.
Topics: Amino Acid Sequence; Bacteroides; beta-Glucosidase; Butylene Glycols; Cloning, Molecular; DNA, Bacterial; Enzyme Stability; Escherichia coli; Gene Expression; Glucosides; Hydrogen-Ion Concentration; Hydrolysis; Lignans; Models, Molecular; Molecular Docking Simulation; Molecular Sequence Data; Recombinant Proteins; Sequence Alignment; Sequence Analysis, DNA; Temperature | 2014 |
Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs).
Topics: Antioxidants; Benzaldehydes; Butylene Glycols; Flax; Free Radical Scavengers; Glucosides; Molecular Structure | 2013 |
Bioaccessibility of lignans from flaxseed (Linum usitatissimum L.) determined by single-batch in vitro simulation of the digestive process.
Topics: 4-Butyrolactone; Bacteria, Anaerobic; Biological Availability; Butylene Glycols; Colon; Fatty Acids, Volatile; Fermentation; Flax; Glucosides; Humans; In Vitro Techniques; Lignans; Seeds | 2014 |
Permeability and conjugative metabolism of flaxseed lignans by Caco-2 human intestinal cells.
Topics: 4-Butyrolactone; Algorithms; Butylene Glycols; Caco-2 Cells; Chromatography, High Pressure Liquid; Flax; Glucosides; Humans; Intestinal Mucosa; Lignans; Molecular Structure; Permeability | 2014 |
Isolation, characterization and antihyperlipidemic activity of secoisolariciresinol diglucoside in poloxamer-407-induced experimental hyperlipidemia.
Topics: Animals; Butylene Glycols; Chromatography, Thin Layer; Disease Models, Animal; Flax; Glucosides; Hyperlipidemias; Hypolipidemic Agents; Lipids; Mice; Poloxamer; Rats; Spectrum Analysis | 2014 |
Identification and functional characterization of a flax UDP-glycosyltransferase glucosylating secoisolariciresinol (SECO) into secoisolariciresinol monoglucoside (SMG) and diglucoside (SDG).
Topics: Amino Acid Motifs; Amino Acid Sequence; Biosynthetic Pathways; Butylene Glycols; Chromatography, High Pressure Liquid; Cloning, Molecular; Conserved Sequence; DNA, Complementary; Enzyme Assays; Expressed Sequence Tags; Flax; Gene Expression Profiling; Gene Expression Regulation, Plant; Genes, Plant; Glucosides; Glycosylation; Glycosyltransferases; Kinetics; Lignans; Mass Spectrometry; Molecular Sequence Data; Organ Specificity; Oxidoreductases; Phylogeny; Sesamum | 2014 |
Novel synthetic (S,S) and (R,R)-secoisolariciresinol diglucosides (SDGs) protect naked plasmid and genomic DNA From gamma radiation damage.
Topics: Animals; Butylene Glycols; Cattle; Chemistry Techniques, Synthetic; DNA; DNA Damage; DNA Fragmentation; DNA, Superhelical; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Gamma Rays; Genome; Glucosides; Molecular Weight; Plasmids; Radiation-Protective Agents; Stereoisomerism | 2014 |
Secoisolariciresinol diglucoside in high-fat diet and streptozotocin-induced diabetic nephropathy in rats: a possible renoprotective effect.
Topics: Animals; Apoptosis; Butylene Glycols; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diet, High-Fat; Drug Evaluation, Preclinical; Glucosides; Hypoglycemic Agents; Kidney; Male; Microtubule-Associated Proteins; Nitric Oxide Synthase Type II; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Rats, Sprague-Dawley; Streptozocin; Survivin; Tumor Necrosis Factor-alpha | 2014 |
Comparative pharmacokinetics of purified flaxseed and associated mammalian lignans in male Wistar rats.
Topics: 4-Butyrolactone; Administration, Oral; Animals; Biological Availability; Butylene Glycols; Dietary Supplements; Dose-Response Relationship, Drug; Estrogens; Flax; Glucosides; Half-Life; Injections, Intravenous; Intestinal Absorption; Kinetics; Lignans; Male; Metabolic Clearance Rate; Phytoestrogens; Random Allocation; Rats, Wistar; Seeds | 2015 |
Secoisolariciresinol diglucoside abrogates oxidative stress-induced damage in cardiac iron overload condition.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; bcl-2-Associated X Protein; Butylene Glycols; Cell Line; Cytokines; Cytoprotection; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Expression Regulation, Enzymologic; Glucosides; Iron; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Myocytes, Cardiac; Oxidation-Reduction; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Rats; Ribosomal Protein S6 Kinases, 70-kDa; Superoxide Dismutase | 2015 |
Dirigent Protein-Mediated Lignan and Cyanogenic Glucoside Formation in Flax Seed: Integrated Omics and MALDI Mass Spectrometry Imaging.
Topics: Butylene Glycols; Flax; Furans; Glucosides; Glycosides; Lignans; Molecular Structure; Nitriles; Seeds; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2015 |
Effects of Flaxseed Lignan Secoisolariciresinol Diglucosideon Preneoplastic Biomarkers of Cancer Progression in a Model of Simultaneous Breast and Ovarian Cancer Development.
Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Butylene Glycols; Cell Adhesion; Disease Models, Animal; Disease Progression; Drug Evaluation, Preclinical; Estrogen Receptor Modulators; Female; Flax; Glucosides; Ki-67 Antigen; Ovarian Neoplasms; Phytoestrogens; Precancerous Conditions; Rats; Rats, Inbred ACI; Seeds | 2015 |
Negative-Pressure Cavitation Extraction of Secoisolariciresinol Diglycoside from Flaxseed Cakes.
Topics: Butylene Glycols; Chemical Fractionation; Flax; Glucosides; Plant Extracts | 2015 |
Ionic Liquid-Based Ultrasonic-Assisted Extraction of Secoisolariciresinol Diglucoside from Flaxseed (Linum usitatissimum L.) with Further Purification by an Aqueous Two-Phase System.
Topics: Analysis of Variance; Butylene Glycols; Flax; Glucosides; Hydrogen-Ion Concentration; Liquid-Liquid Extraction; Plant Extracts; Salts; Temperature; Ultrasonic Waves | 2015 |
Flaxseed lignans enriched in secoisolariciresinol diglucoside prevent acute asbestos-induced peritoneal inflammation in mice.
Topics: Animals; Antioxidants; Asbestos, Crocidolite; Butylene Glycols; Chromatography, Liquid; Diet; Dietary Supplements; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Flax; Glucosides; Inflammation; Lignans; Mesothelioma; Mice; Mice, Mutant Strains; Oxidative Stress; Peritoneal Lavage; Peritoneum; Precancerous Conditions; Reverse Transcriptase Polymerase Chain Reaction; Seeds; Tandem Mass Spectrometry; Transcriptome | 2016 |
The Flaxseed-Derived Lignan Phenolic Secoisolariciresinol Diglucoside (SDG) Protects Non-Malignant Lung Cells from Radiation Damage.
Topics: Animals; Antioxidants; Butylene Glycols; Cell Death; Cells, Cultured; DNA Damage; Endothelial Cells; Flax; Gamma Rays; Glucosides; Glutathione Transferase; Heme Oxygenase-1; Lung; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; NAD(P)H Dehydrogenase (Quinone); Plant Extracts | 2015 |
Detection of novel metabolites of flaxseed lignans in vitro and in vivo.
Topics: 4-Butyrolactone; Adult; Bifidobacterium pseudocatenulatum; Butylene Glycols; Dietary Supplements; Feces; Female; Flax; Furans; Gastrointestinal Microbiome; Glucosides; Humans; Intestinal Mucosa; Intestines; Lignans; Male; Middle Aged; Prebiotics; Probiotics; Young Adult | 2016 |
Asbestos Induces Oxidative Stress and Activation of Nrf2 Signaling in Murine Macrophages: Chemopreventive Role of the Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605).
Topics: Animals; Antioxidants; Asbestos; Butylene Glycols; Cells, Cultured; Glucosides; Macrophages, Peritoneal; Mice; NF-E2-Related Factor 2; Oxidative Stress; Signal Transduction | 2016 |
Gamma-irradiation produces active chlorine species (ACS) in physiological solutions: Secoisolariciresinol diglucoside (SDG) scavenges ACS - A novel mechanism of DNA radioprotection.
Topics: 2-Aminopurine; Animals; Antioxidants; Butylene Glycols; Cattle; Chlorine; DNA; DNA Fragmentation; Flax; Free Radical Scavengers; Gamma Rays; Glucosides; Hydroxyl Radical; Lignans; Lipid Peroxidation; Plasmids; Radiation-Protective Agents | 2016 |
Secoisolariciresinol diglucoside rich extract of L. usitatissimum prevents diabetic colon cancer through inhibition of CDK4.
Topics: Animals; Biomarkers, Tumor; Butylene Glycols; Cell Proliferation; Colonic Neoplasms; Cyclin-Dependent Kinase 4; Cytokines; Diabetes Mellitus, Type 2; Female; Flax; Gene Expression Regulation, Neoplastic; Glucose Tolerance Test; Glucosides; Hyperglycemia; Inflammation Mediators; Male; Phytochemicals; Plant Extracts; Proliferating Cell Nuclear Antigen; Rats, Sprague-Dawley; RNA, Messenger | 2016 |
Comparison of phytochemical profiles and health benefits in fiber and oil flaxseeds (Linum usitatissimum L.).
Topics: Butylene Glycols; Chromatography, High Pressure Liquid; Coumaric Acids; Dietary Fiber; Flavonoids; Flax; Glucosides; Linseed Oil; Phenols; Phytochemicals; Propionates; Seeds | 2017 |
Kinetics of the incorporation of the main phenolic compounds into the lignan macromolecule during flaxseed development.
Topics: Butylene Glycols; Flavonoids; Flax; Glucosides; Hydrolysis; Kinetics; Lignans; Macromolecular Substances; Magnetic Resonance Spectroscopy; Phenols; Seeds | 2017 |
The treatment effects of flaxseed-derived secoisolariciresinol diglycoside and its metabolite enterolactone on benign prostatic hyperplasia involve the G protein-coupled estrogen receptor 1.
Topics: 4-Butyrolactone; Animals; Antineoplastic Agents, Phytogenic; Binding Sites; Butylene Glycols; Cell Line, Tumor; Cell Proliferation; Dietary Supplements; Flax; Gene Expression Regulation, Neoplastic; Glucosides; Glycosides; Humans; Lignans; Male; Models, Molecular; Molecular Docking Simulation; Neoplasm Proteins; Prostate; Prostatic Hyperplasia; Random Allocation; Rats; Rats, Wistar; Receptors, Estrogen; Receptors, G-Protein-Coupled; RNA Interference; Seeds | 2016 |
Secoisolariciresinol Diglucoside and Cyanogenic Glycosides in Gluten-free Bread Fortified with Flaxseed Meal.
Topics: Amygdalin; Bread; Butylene Glycols; Chromatography, High Pressure Liquid; Flax; Flour; Food, Fortified; Glucosides; Glutens; Glycosides; Lignans; Magnetic Resonance Spectroscopy; Nitriles; Temperature | 2016 |
UGT74S1 is the key player in controlling secoisolariciresinol diglucoside (SDG) formation in flax.
Topics: Butylene Glycols; Evolution, Molecular; Flax; Gene Duplication; Gene Expression; Genes, Plant; Genetic Variation; Genome, Plant; Glucosides; Lignans | 2017 |
Secoisolariciresinol diglucoside attenuates cardiac hypertrophy and oxidative stress in monocrotaline-induced right heart dysfunction.
Topics: Animals; Butylene Glycols; Cardiomegaly; Glucosides; Male; Monocrotaline; Oxidative Stress; Rats; Rats, Wistar; Ventricular Dysfunction, Right | 2017 |
Protective Role of Flaxseed Oil and Flaxseed Lignan Secoisolariciresinol Diglucoside Against Oxidative Stress in Rats with Metabolic Syndrome.
Topics: Animals; Antioxidants; Body Weight; Butylene Glycols; Flax; Fructose; Glucose; Glucosides; Humans; Lignans; Linseed Oil; Lipids; Male; Metabolic Syndrome; Oxidative Stress; Protective Agents; Quality of Life; Rats | 2017 |
Determination of lignans, phenolic acids and antioxidant capacity in transformed hairy root culture of Linum usitatissimum.
Topics: Antioxidants; Biphenyl Compounds; Butylene Glycols; Flax; Furans; Glucosides; Hydroxybenzoates; Lignans; Picrates; Plant Roots; Tissue Culture Techniques | 2018 |
Synthetic Secoisolariciresinol Diglucoside (LGM2605) Protects Human Lung in an Ex Vivo Model of Proton Radiation Damage.
Topics: Anti-Inflammatory Agents; Butylene Glycols; Cell Cycle Checkpoints; Cellular Senescence; Glucosides; Humans; Lung; Oxidative Stress; Protons; Radiation Pneumonitis; Radiation-Protective Agents | 2017 |
Secoisolariciresinol diglucoside inhibits adipogenesis through the AMPK pathway.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; AMP-Activated Protein Kinases; Animals; Butylene Glycols; Cell Survival; Diet, High-Fat; Glucosides; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Obesity; Signal Transduction | 2018 |
Microbial and Chemical Shelf-Life of Vacuum Steam-Pasteurized Whole Flaxseed and Milled Flaxseed.
Topics: Butylene Glycols; Colony Count, Microbial; Fatty Acids; Flax; Food Contamination; Food Handling; Food Microbiology; Glucosides; Pasteurization; Peroxides; Steam; Vacuum; Volatile Organic Compounds; Water | 2018 |
Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: implications for neuroinflammation.
Topics: Animals; Anti-Inflammatory Agents; Blood-Brain Barrier; Butylene Glycols; Cell Movement; Dose-Response Relationship, Drug; Endothelium, Vascular; Glucosides; Humans; Inflammation Mediators; Male; Mice; Microvessels | 2018 |
Synthetic secoisolariciresinol diglucoside (LGM2605) inhibits myeloperoxidase activity in inflammatory cells.
Topics: Animals; Butylene Glycols; Catalysis; Cells, Cultured; Gene Expression Regulation, Enzymologic; Glucosides; Humans; Leukocytes; Macrophages; Mice; Mice, Inbred C57BL; Neutrophils; Oxidation-Reduction; Peroxidase | 2018 |
Secoisolariciresinol diglucoside prevents the oxidative stress-induced apoptosis of myocardial cells through activation of the JAK2/STAT3 signaling pathway.
Topics: Animals; Apoptosis; Blotting, Western; Butylene Glycols; Cell Line; Cell Survival; Flow Cytometry; Glucosides; Hydrogen Peroxide; Janus Kinase 2; Oxidative Stress; Rats; Signal Transduction; STAT3 Transcription Factor | 2018 |
In vitro cultures of Linum usitatissimum L.: Synergistic effects of mineral nutrients and photoperiod regimes on growth and biosynthesis of lignans and neolignans.
Topics: Biomass; Boron; Butylene Glycols; Chromatography, High Pressure Liquid; Flavonoids; Flax; Free Radical Scavengers; Glucosides; Kinetics; Light; Lignans; Nitrogen; Phenols | 2018 |
The flaxseed lignan secoisolariciresinol diglucoside decreases local inflammation, suppresses NFκB signaling, and inhibits mammary tumor growth.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Biomarkers; Butylene Glycols; Cell Line, Tumor; Cell Survival; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Flax; Gene Expression Profiling; Glucosides; Immunohistochemistry; Lignans; Mammary Neoplasms, Animal; Mice; NF-kappa B; Signal Transduction | 2019 |
Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy.
Topics: Animals; Antioxidants; Autophagy; Biomarkers; Butylene Glycols; Calcium; Cardiomyopathies; Cecum; Cell Line; Cytokines; Disease Models, Animal; Gene Expression Regulation; Glucosides; Humans; Inflammation Mediators; Ligation; Membrane Potential, Mitochondrial; Mice, Inbred C57BL; Mitochondria, Heart; Myocardium; Myocytes, Cardiac; NF-kappa B; Organelle Biogenesis; Oxidative Stress; Oxygen Consumption; Punctures; Sepsis | 2019 |
LGM2605 Reduces Space Radiation-Induced NLRP3 Inflammasome Activation and Damage in In Vitro Lung Vascular Networks.
Topics: Animals; Antioxidants; Butylene Glycols; Gamma Rays; Glucosides; Humans; Inflammasomes; Inflammation; Intercellular Adhesion Molecule-1; Linear Energy Transfer; Lung; NLR Family, Pyrin Domain-Containing 3 Protein; Phenotype; Protons; Radiation-Protective Agents | 2019 |
Synthetic secoisolariciresinol diglucoside (LGM2605) inhibits Libby amphibole fiber-induced acute inflammation in mice.
Topics: Animals; Asbestos, Amphibole; Butylene Glycols; Female; Glucosides; Inflammation; Male; Mice; Mice, Inbred C57BL; Organ Size; Peritoneum; Spleen | 2019 |
Development and validation of an ultra-high performance liquid chromatography-high resolution mass spectrometry method for simultaneous quantification of cyanogenic glycosides and secoisolariciresinol diglucoside in flaxseed (Linum usitatissimum L.).
Topics: Amygdalin; Butylene Glycols; Chemistry Techniques, Analytical; Chromatography, High Pressure Liquid; Flax; Glucosides; Glycosides; Hydrolysis; Lignans; Mass Spectrometry; Seeds | 2019 |
Dietary flaxseed protects against ventricular arrhythmias and left ventricular dilation after a myocardial infarction.
Topics: alpha-Linolenic Acid; Animals; Arrhythmias, Cardiac; Body Weight; Butylene Glycols; Cardiotonic Agents; Dietary Supplements; Electrocardiography; Fatty Acids; Flax; Glucosides; Male; Myocardial Infarction; Myocarditis; Organ Size; Rats, Sprague-Dawley; Ventricular Remodeling | 2019 |
Effect of flaxseed polyphenols on physical stability and oxidative stability of flaxseed oil-in-water nanoemulsions.
Topics: Antioxidants; Butylene Glycols; Emulsions; Flax; Glucosides; Hydrolysis; Lignans; Linseed Oil; Nanostructures; Oxidation-Reduction; Plant Extracts; Polyphenols; Water | 2019 |
Ozone-induced enhancement of airway hyperreactivity in rhesus macaques: Effects of antioxidant treatment.
Topics: Animals; Antioxidants; Asthma; Butylene Glycols; CD4-Positive T-Lymphocytes; Dendritic Cells; Female; Glucosides; Macaca mulatta; Male; Myeloid Cells; Ozone | 2020 |
Secoisolariciresinol diglucoside suppresses Dextran sulfate sodium salt-induced colitis through inhibiting NLRP1 inflammasome.
Topics: Adaptor Proteins, Signal Transducing; Animals; Anti-Inflammatory Agents; Apoptosis Regulatory Proteins; Butylene Glycols; Colitis; Colon; Cytokines; Dextran Sulfate; Glucosides; Inflammasomes; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; RAW 264.7 Cells | 2020 |
Secoisolariciresinol diglucoside alleviates hepatic lipid metabolic misalignment involving the endoplasmic reticulum-mitochondrial axis.
Topics: Animals; Butylene Glycols; Calcium; Diet, High-Fat; Down-Regulation; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Energy Intake; Fatty Acids; Gene Expression Regulation; Glucosides; Hep G2 Cells; Humans; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Mitochondria; Palmitic Acid; Up-Regulation; Weight Gain | 2020 |
A phytoestrogen secoisolariciresinol diglucoside induces browning of white adipose tissue and activates non-shivering thermogenesis through AMPK pathway.
Topics: 3T3-L1 Cells; Adipocytes, Brown; Adipose Tissue, Brown; Adipose Tissue, White; AMP-Activated Protein Kinases; Animals; Butylene Glycols; Diet, High-Fat; Glucose Tolerance Test; Glucosides; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Organelle Biogenesis; Phytoestrogens; Signal Transduction; Thermogenesis | 2020 |
Secoisolariciresinol Diglucoside Delays the Progression of Aging-Related Diseases and Extends the Lifespan of
Topics: Aging; Animals; Butylene Glycols; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Disease Progression; Forkhead Transcription Factors; Glucosides; Longevity; Oxidative Stress; Transcription Factors | 2020 |
Cardioprotective Effects of Dietary Flaxseed Post-Infarction Are Associated with Changes in MicroRNA Expression.
Topics: alpha-Linolenic Acid; Animal Feed; Animals; Butylene Glycols; Collagen Type I; Disease Models, Animal; Fatty Acids; Flax; Glucosides; Homeodomain Proteins; Male; MicroRNAs; Myocardial Infarction; Rats, Sprague-Dawley; Seeds; Up-Regulation | 2020 |
Antiestrogenic and antiproliferative potency of secoisolariciresinol diglucoside derivatives on MCF-7 breast cancer cells.
Topics: Breast Neoplasms; Butylene Glycols; Female; Flax; Glucosides; Humans; Lignans; MCF-7 Cells | 2021 |
The anti-cancer effect of flaxseed lignan derivatives on different acute myeloid leukemia cancer cells.
Topics: 4-Butyrolactone; Antineoplastic Agents, Phytogenic; Apoptosis; Butylene Glycols; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Child; Female; Flax; Glucosides; Humans; Leukemia, Myeloid, Acute; Lignans; Plant Extracts; Reactive Oxygen Species; Seeds | 2020 |
Secoisolariciresinol diglucoside induces caspase-3-mediated apoptosis in monolayer and spheroid cultures of human colon carcinoma cells.
Topics: Animals; Apoptosis; Butylene Glycols; Carcinoma; Caspase 3; Colonic Neoplasms; Glucosides; Humans | 2021 |
Short-term exposure to synthetic flaxseed lignan LGM2605 alters gut microbiota in mice.
Topics: Administration, Oral; Animals; Anti-Infective Agents; Biodiversity; Butylene Glycols; Cecum; Computational Biology; Dysbiosis; Female; Flax; Gastrointestinal Microbiome; Glucosides; Lignans; Mice; Mice, Inbred C57BL; RNA, Ribosomal, 16S; Seeds | 2021 |
Oral Pharmacokinetics of Enriched Secoisolariciresinol Diglucoside and Its Polymer in Rats.
Topics: 4-Butyrolactone; Animals; Biological Availability; Butylene Glycols; Female; Flax; Glucosides; Lignans; Molecular Structure; Polymers; Rats; Rats, Wistar; Seeds | 2021 |
Assessment of a Small Molecule Synthetic Lignan in Enhancing Oxidative Balance and Decreasing Lipid Accumulation in Human Retinal Pigment Epithelia.
Topics: Antioxidants; Autophagy; Butylene Glycols; Cell Line; Cytokines; Gene Expression; Glucosides; Humans; Inflammation; Lignans; Lipid Metabolism; Lipids; Mitochondria; Oxidation-Reduction; Oxidative Stress; Phagocytosis; Phagosomes; Retinal Pigment Epithelium; Retinal Pigments | 2021 |
Discriminatory and cooperative effects within the mouse gut microbiota in response to flaxseed and its oil and lignan components.
Topics: Animals; Butylene Glycols; Cecum; Diet; Dietary Fiber; Fatty Acids, Omega-3; Feces; Female; Flax; Gastrointestinal Microbiome; Glucosides; Lignans; Linseed Oil; Mice; Mice, Inbred C57BL | 2021 |
Copper Oxide Nanoparticle-Induced Acute Inflammatory Response and Injury in Murine Lung Is Ameliorated by Synthetic Secoisolariciresinol Diglucoside (LGM2605).
Topics: Animals; Bronchoalveolar Lavage Fluid; Butylene Glycols; Chlorine; Copper; DNA Damage; Female; Glucosides; Inflammasomes; Inflammation; Lung; Metal Nanoparticles; Mice; Mice, Inbred C57BL; Oxidative Stress; Oxides; Peroxidase; Reactive Oxygen Species | 2021 |
Late Inflammation Induced by Asbestiform Fibers in Mice Is Ameliorated by a Small Molecule Synthetic Lignan.
Topics: Adaptive Immunity; Animals; Asbestos, Amphibole; B-Lymphocytes; Butylene Glycols; Chemokine CCL2; Female; Glucosides; Immunity, Innate; Immunoglobulin Isotypes; Immunoglobulins; Inflammation; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; T-Lymphocytes | 2021 |
Hypocholesterolemic Efficacy of Secoisolariciresinol Diglucoside and Its Polymer in Rat.
Topics: Animals; Anticholesteremic Agents; Body Weight; Butylene Glycols; Female; Glucosides; Lipids; Liver; Organ Size; Polymers; Rats; Rats, Wistar | 2021 |
Secoisolariciresinol diglucoside mitigates benzo[a]pyrene-induced liver and kidney toxicity in mice via miR-101a/MKP-1-mediated p38 and ERK pathway.
Topics: Acute Kidney Injury; Animals; Benzo(a)pyrene; Butylene Glycols; Chemical and Drug Induced Liver Injury; Dual Specificity Phosphatase 1; Glucosides; Male; MAP Kinase Signaling System; Mice; MicroRNAs; Protective Agents | 2022 |
Secoisolariciresinol diglucoside ameliorates high fat diet-induced colon inflammation and regulates gut microbiota in mice.
Topics: Animals; Anti-Inflammatory Agents; Butylene Glycols; Colitis; Diet, High-Fat; Disease Models, Animal; Gastrointestinal Microbiome; Glucosides; Inflammation; Male; Mice; Mice, Inbred C57BL | 2022 |
Secoisolariciresinol diglucoside induces pyroptosis by activating caspase-1 to cleave GSDMD in colorectal cancer cells.
Topics: Animals; bcl-2-Associated X Protein; Butylene Glycols; Caspase 1; Colorectal Neoplasms; Glucosides; HCT116 Cells; Humans; Mice; Phosphate-Binding Proteins; Phosphatidylinositol 3-Kinases; Pore Forming Cytotoxic Proteins; Proto-Oncogene Proteins c-akt; Pyroptosis; Reactive Oxygen Species | 2022 |
Secoisolariciresinol diglucoside-derived metabolite, enterolactone, attenuates atopic dermatitis by suppressing Th2 immune response.
Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents; Butylene Glycols; Child, Preschool; Dermatitis, Atopic; Dinitrochlorobenzene; Glucosides; Humans; Immunity; Lignans; Mice; Mice, Inbred BALB C; Skin | 2022 |
Synthetic Secoisolariciresinol Diglucoside (LGM2605) Prevents Asbestos-Induced Inflammation and Genotoxic Cell Damage in Human Mesothelial Cells.
Topics: Asbestos; Butylene Glycols; Cytokines; DNA Damage; Glucosides; HMGB1 Protein; Humans; Inflammasomes; Inflammation; Interleukin-18; Interleukin-6; Reactive Oxygen Species; Tumor Necrosis Factor-alpha | 2022 |