Page last updated: 2024-09-04

glucagon and yohimbine

glucagon has been researched along with yohimbine in 36 studies

Compound Research Comparison

Studies
(glucagon)
Trials
(glucagon)
Recent Studies (post-2010)
(glucagon)
Studies
(yohimbine)
Trials
(yohimbine)
Recent Studies (post-2010) (yohimbine)
26,0391,4983,0545,893253532

Protein Interaction Comparison

ProteinTaxonomyglucagon (IC50)yohimbine (IC50)
Alpha-2A adrenergic receptorHomo sapiens (human)0.0353
Cytochrome P450 2D6Homo sapiens (human)1.02
D(2) dopamine receptorHomo sapiens (human)2.06
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)1.3
Alpha-2B adrenergic receptorHomo sapiens (human)0.0428
Alpha-2C adrenergic receptorHomo sapiens (human)0.0466
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)0.126
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)0.0682
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)0.0682
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)0.0682
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)1.3
Alpha-1D adrenergic receptorHomo sapiens (human)1.013
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)0.126
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.074
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)1.3
5-hydroxytryptamine receptor 6Homo sapiens (human)1.689

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199016 (44.44)18.7374
1990's12 (33.33)18.2507
2000's7 (19.44)29.6817
2010's1 (2.78)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gross, R; Hillaire-Buys, D; Loubatières-Mariani, MM; Ribes, G; Roye, M1
Brase, DA; Dewey, WL; Tripathi, HL; Ward, CR1
Fujimura, H; Oda, S; Ohneda, A; Sasaki, Y1
Ahrén, B; Karlsson, S2
Oda, S; Ohneda, A; Sasaki, Y; Tsuda, T1
Faulkner, A; Pollock, HT1
Blayac, JP; Gross, R; Hillaire-Buys, D; Loubatières-Mariani, MM; Ribes, G1
Gotoh, M; Iguchi, A; Matsunaga, H; Miura, H; Sakamoto, N; Satake, T; Tamagawa, T; Uemura, K; Yatomi, A1
Fujii, T; Inoue, S; Nagai, K; Nakagawa, H1
Dileepan, KN; Wagle, SR1
Gotoh, M; Iguchi, A; Sakamoto, N1
Ahrén, B; Dunning, BE; Taborsky, GJ; Veith, RC1
Ahrén, B; Pettersson, M1
Knudtzon, J3
Bertrand, G; Gross, R; Loubatières-Mariani, MM; Ribes, G1
Bégin-Heick, N; Welsh, J1
Edminson, PD; Knudtzon, J; Reichelt, KL1
Dileepan, KN; Khawaja, AM; Wagle, SR1
Patel, DG1
Bygrave, FL; Reinhart, PH; Taylor, WM1
Bogoyevitch, MA; Fuller, SJ; Sugden, PH1
Alvarez, C; Bladé, C; Cartañà, J1
Hirose, H; Ito, K; Kido, K; Koyama, K; Maruyama, H; Saruta, T2
Koizumi, F; Ohneda, A; Ohneda, K1
Adeghate, E; Ponery, AS; Wahab, A1
Aarnio, P; Dela, F; Lauritsen, T1
Adeghate, E; Ponery, AS1
Ernsberger, P; Koletsky, RJ; Velliquette, RA1
Bentho, O; Eisenhofer, G; Geraci, MF; Goldstein, DS; Holmes, C; Pacak, K; Pechnik, S; Saleem, A; Sharabi, Y1
Goldstein, DS; Holmes, C; Imrich, R; Pechnik, S; Sharabi, Y1
Goldstein, DS; Holmes, C1
Andersson, LE; Axelsson, AS; Groop, LC; Mulder, H; Renström, E; Rosengren, AH; Spégel, P; Tang, Y1

Reviews

1 review(s) available for glucagon and yohimbine

ArticleYear
Somatostatin: a metabolic regulator.
    Life sciences, 1985, Dec-23, Volume: 37, Issue:25

    Topics: Adrenocorticotropic Hormone; Animals; Bicarbonates; Bile; Blood Glucose; Calcium; Cyclic AMP; Digestive System Physiological Phenomena; Glucagon; Gluconeogenesis; Glycogen; Growth Hormone; Homeostasis; Humans; Insulin; Insulin Secretion; Kidney Cortex; Liver; Pancreas; Pituitary Gland; Prazosin; Prolactin; Pyruvates; Pyruvic Acid; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Somatostatin; Thyrotropin; Yohimbine

1985

Trials

1 trial(s) available for glucagon and yohimbine

ArticleYear
Genotype-based treatment of type 2 diabetes with an α2A-adrenergic receptor antagonist.
    Science translational medicine, 2014, Oct-08, Volume: 6, Issue:257

    Topics: Adrenergic alpha-2 Receptor Antagonists; Aged; Alleles; Blood Pressure; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Female; Gene Expression; Genetic Variation; Genotype; Glucagon; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Male; Middle Aged; Norepinephrine; Receptors, Adrenergic, alpha-2; Translational Research, Biomedical; Yohimbine

2014

Other Studies

34 other study(ies) available for glucagon and yohimbine

ArticleYear
Adrenergic inhibition of insulin secretion involves pertussis toxin-sensitive and -insensitive mechanisms.
    European journal of pharmacology, 1992, Aug-06, Volume: 218, Issue:2-3

    Topics: Analysis of Variance; Animals; Epinephrine; Glucagon; GTP-Binding Proteins; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Pertussis Toxin; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Virulence Factors, Bordetella; Yohimbine

1992
An insulin-independent mechanism of intrathecal morphine-induced hypoglycemia in mice: mediation through a central alpha-2 adrenergic pathway.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 257, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Blood Glucose; Body Temperature; Drug Interactions; Glucagon; Hypoglycemia; Injections, Spinal; Insulin; Male; Mice; Mice, Inbred ICR; Morphine; Receptors, Adrenergic, alpha; Yohimbine

1991
Alpha 2-adrenergic modulation of glucagon and insulin secretions in sheep.
    The Tohoku journal of experimental medicine, 1991, Volume: 163, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Blood Glucose; Clonidine; Dose-Response Relationship, Drug; Glucagon; Imidazoles; Insulin; Male; Pancreas; Radioimmunoassay; Receptors, Adrenergic, alpha; Sheep; Yohimbine

1991
Insulin and glucagon secretion in swimming mice: effects of autonomic receptor antagonism.
    Metabolism: clinical and experimental, 1990, Volume: 39, Issue:7

    Topics: Animals; Autonomic Nervous System; Blood Glucose; Female; Ganglionic Blockers; Glucagon; Hexamethonium; Hexamethonium Compounds; Insulin; Insulin Secretion; Mice; Phentolamine; Physical Exertion; Propranolol; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Swimming; Yohimbine

1990
Glucagon and insulin responses to alpha-adrenergic subtype receptor blockade in sheep.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1990, Volume: 96, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Epinephrine; Glucagon; Infusions, Intravenous; Insulin; Insulin Secretion; Male; Prazosin; Propranolol; Receptors, Adrenergic, alpha; Sheep; Yohimbine

1990
Effects of glucagon and alpha- and beta-agonists on glycogenolysis and gluconeogenesis in isolated ovine hepatocytes.
    Biochimica et biophysica acta, 1990, Apr-09, Volume: 1052, Issue:1

    Topics: Animals; Bucladesine; Cells, Cultured; Glucagon; Gluconeogenesis; Isoproterenol; Kinetics; Liver; Liver Glycogen; Phenylephrine; Prazosin; Sheep; Vasopressins; Yohimbine

1990
Involvement of a central nervous pathway in yohimbine-induced insulin secretion.
    European journal of pharmacology, 1989, Mar-21, Volume: 162, Issue:2

    Topics: Animals; Blood Glucose; Blood Pressure; Central Nervous System; Dogs; Glucagon; Injections, Intravenous; Insulin; Insulin Secretion; Neural Pathways; Pancreas; Propranolol; Regional Blood Flow; Somatostatin; Time Factors; Vagotomy; Yohimbine

1989
Central nervous system-mediated glucagon secretion is enhanced by alpha 2-adrenoreceptor activation.
    Endocrinology, 1989, Volume: 125, Issue:3

    Topics: Adrenalectomy; Adrenergic alpha-Antagonists; Animals; Blood Glucose; Cerebral Ventricles; Glucagon; Hexamethonium; Hexamethonium Compounds; Injections, Intraventricular; Male; Neostigmine; Norepinephrine; Phentolamine; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Reference Values; Yohimbine

1989
Involvement of adrenergic mechanism in hyperglycemia due to SCN stimulation.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1989, Volume: 21, Issue:12

    Topics: Adrenergic alpha-Antagonists; Animals; Autonomic Nervous System; Electric Stimulation; Female; Glucagon; Hexamethonium; Hexamethonium Compounds; Hyperglycemia; Insulin; Propranolol; Quinazolines; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Suprachiasmatic Nucleus; Yohimbine

1989
Central versus peripheral effect of clonidine on hepatic venous plasma glucose concentrations in fasted rats.
    Diabetes, 1988, Volume: 37, Issue:1

    Topics: Animals; Blood Glucose; Clonidine; Fasting; Glucagon; Hepatic Veins; Injections, Intravenous; Injections, Intraventricular; Insulin; Kinetics; Male; Phentolamine; Rats; Rats, Inbred Strains; Somatostatin; Yohimbine

1988
Nonadrenergic sympathetic neural influences on basal pancreatic hormone secretion.
    The American journal of physiology, 1988, Volume: 255, Issue:6 Pt 1

    Topics: Animals; Atropine; Dogs; Electric Stimulation; Glucagon; Insulin; Insulin Secretion; Islets of Langerhans; Norepinephrine; Propranolol; Reference Values; Somatostatin; Sympathetic Nervous System; Yohimbine

1988
Insulin and glucagon secretion in rats: effects of calcitonin gene-related peptide.
    Regulatory peptides, 1988, Volume: 23, Issue:1

    Topics: Animals; Arginine; Blood Glucose; Calcitonin; Calcitonin Gene-Related Peptide; Dose-Response Relationship, Drug; Glucagon; Insulin; Insulin Secretion; Kinetics; Male; Neuropeptides; Rats; Rats, Inbred Strains; Reference Values; Somatostatin; Yohimbine

1988
Hypoinsulinemic and hyperglycemic effects of beta-endorphin in rabbits.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1986, Volume: 18, Issue:8

    Topics: Animals; Atropine; beta-Endorphin; Blood Glucose; Endorphins; Female; Glucagon; Hyperglycemia; Injections, Intravenous; Insulin; Naloxone; Phentolamine; Propranolol; Quaternary Ammonium Compounds; Rabbits; Yohimbine

1986
Alpha 2-adrenergic potentiation of adenosine-stimulating effect on glucagon secretion.
    Endocrinology, 1987, Volume: 121, Issue:2

    Topics: Adenosine; Animals; Clonidine; Drug Synergism; Epinephrine; Glucagon; Male; Pancreas; Phenylephrine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Yohimbine

1987
The regulation of adenylate cyclase in liver membranes of lean and obese mice.
    Molecular and cellular endocrinology, 1988, Volume: 59, Issue:3

    Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Cell Membrane; Cholera Toxin; Enzyme Activation; Glucagon; Guanosine Triphosphate; Isoproterenol; Liver; Magnesium; Magnesium Chloride; Male; Mice; Mice, Inbred C57BL; Norepinephrine; Obesity; Pertussis Toxin; Propranolol; Virulence Factors, Bordetella; Yohimbine

1988
Different acute in vivo effects of bacterial derived and pituitary growth hormone preparations on plasma levels of glucagon, insulin and free fatty acids in rabbits.
    Hormone research, 1985, Volume: 21, Issue:1

    Topics: Animals; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Fatty Acids, Nonesterified; Female; Glucagon; Growth Hormone; Human Growth Hormone; Insulin; Peptides; Rabbits; Yohimbine

1985
Involvement of the autonomic nervous system in the in vivo TRH-induced increases in the plasma levels of glucagon, insulin and glucose in rabbits.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1985, Volume: 17, Issue:2

    Topics: Animals; Atropine; Autonomic Nervous System; Blood Glucose; Fatty Acids, Nonesterified; Female; Glucagon; Hormones; Insulin; Phentolamine; Propranolol; Rabbits; Thyrotropin-Releasing Hormone; Yohimbine

1985
Studies on the mechanism of action of somatostatin on renal gluconeogenesis: evidence for the involvement of alpha 1-adrenergic stimuli.
    Archives of biochemistry and biophysics, 1982, Volume: 213, Issue:1

    Topics: Animals; Calcium; Glucagon; Gluconeogenesis; Insulin; Kidney Cortex; Male; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Reserpine; Somatostatin; Yohimbine

1982
Adrenergic effects on plasma levels of glucagon, insulin, glucose and free fatty acids in rabbits--influences of selective blocking drugs.
    Acta physiologica Scandinavica, 1984, Volume: 120, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Glucose; Epinephrine; Fatty Acids, Nonesterified; Female; Glucagon; Insulin; Isoproterenol; Metoprolol; Prazosin; Propanolamines; Rabbits; Yohimbine

1984
Role of sympathetic nervous system in glucagon response to insulin hypoglycemia in normal and diabetic rats.
    Diabetes, 1984, Volume: 33, Issue:12

    Topics: Animals; Diabetes Mellitus, Experimental; Epinephrine; Glucagon; Hypoglycemia; Insulin; Male; Phentolamine; Propranolol; Rats; Rats, Inbred Strains; Sympathetic Nervous System; Yohimbine

1984
Studies on alpha-adrenergic-induced respiration and glycogenolysis in perfused rat liver.
    The Journal of biological chemistry, 1982, Feb-25, Volume: 257, Issue:4

    Topics: Animals; Antimycin A; Dinitrophenols; Female; Glucagon; Kinetics; Liver; Liver Glycogen; Oxygen Consumption; Phenylephrine; Prazosin; Rats; Rats, Inbred Strains; Rotenone; Yohimbine

1982
cAMP and protein synthesis in isolated adult rat heart preparations.
    The American journal of physiology, 1993, Volume: 265, Issue:5 Pt 1

    Topics: 1-Methyl-3-isobutylxanthine; Adenine Nucleotides; Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Energy Metabolism; Epinephrine; Glucagon; Heart; Hypertension; In Vitro Techniques; Isoproterenol; Kinetics; Male; Myocardium; Perfusion; Phenylephrine; Phosphocreatine; Prazosin; Propranolol; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Yohimbine

1993
Alpha 2-adrenergic blockade prevents hyperglycemia and hepatic glutathione depletion in nickel-injected rats.
    Toxicology and applied pharmacology, 1993, Volume: 121, Issue:1

    Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Female; Glucagon; Glutathione; Hyperglycemia; Insulin; Liver; Nickel; Phentolamine; Prazosin; Propranolol; Rats; Rats, Wistar; Yohimbine

1993
Effects of alpha 2- and beta-adrenergic agonism on glucagon secretion from perfused pancreata of normal and streptozocin-induced diabetic rats.
    Metabolism: clinical and experimental, 1993, Volume: 42, Issue:8

    Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Clonidine; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Glucagon; Glucose; Insulin; Insulin Secretion; Isoproterenol; Male; Norepinephrine; Pancreas; Propranolol; Radioimmunoassay; Rats; Rats, Wistar; Streptozocin; Yohimbine

1993
Mechanism of insulin secretion by midaglizole.
    Diabetes research and clinical practice, 1993, Volume: 19, Issue:2

    Topics: Animals; Blood Glucose; Clonidine; Diazoxide; Dogs; Dose-Response Relationship, Drug; Glucagon; Hypoglycemic Agents; Imidazoles; Insulin; Insulin Secretion; Kinetics; Time Factors; Yohimbine

1993
Adrenoceptor antagonists, but not guanethidine, reduce glucopenia-induced glucagon secretion from perfused rat pancreas.
    Diabetes research and clinical practice, 1995, Volume: 30, Issue:3

    Topics: Adrenergic Agents; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Drug Combinations; Glucagon; Glucose; Guanethidine; Insulin; Insulin Secretion; Male; Norepinephrine; Pancreas; Perfusion; Prazosin; Propranolol; Rats; Rats, Wistar; Time Factors; Tyramine; Yohimbine

1995
Insulin and glucagon secretion by ganglionic nicotinic activation in adrenalectomized mice.
    European journal of pharmacology, 1998, Jan-26, Volume: 342, Issue:2-3

    Topics: Adrenalectomy; Adrenergic alpha-Antagonists; Animals; Blood Glucose; Dimethylphenylpiperazinium Iodide; Female; Ganglionic Stimulants; Glucagon; Insulin; Islets of Langerhans; Mice; Nicotinic Agonists; Receptors, Nicotinic; Yohimbine

1998
Effect of electrical field stimulation on insulin and glucagon secretion from the pancreas of normal and diabetic rats.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2001, Volume: 33, Issue:5

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atropine; Diabetes Mellitus, Experimental; Electric Stimulation; Glucagon; Insulin; Muscarinic Antagonists; Pancreas; Propranolol; Radioimmunoassay; Rats; Yohimbine

2001
Insulin secretion and glucose kinetics during exercise with and without pharmacological alpha(1)- and alpha(2)-receptor blockade.
    Diabetes, 2001, Volume: 50, Issue:8

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Adult; Blood Glucose; Blood Pressure; C-Peptide; Cross-Over Studies; Epinephrine; Exercise; Fatty Acids, Nonesterified; Glucagon; Glycerol; Heart Rate; Hemodynamics; Humans; Insulin; Insulin Secretion; Kinetics; Lactates; Male; Physical Exertion; Prazosin; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Time Factors; Tritium; Yohimbine

2001
The role of leucine-enkephalin on insulin and glucagon secretion from pancreatic tissue fragments of normal and diabetic rats.
    Archives of physiology and biochemistry, 2001, Volume: 109, Issue:3

    Topics: Animals; Atropine; Diabetes Mellitus, Experimental; Enkephalin, Leucine; Glucagon; Insulin; Insulin Secretion; Naloxone; Pancreas; Rats; Yohimbine

2001
The role of I(1)-imidazoline receptors and alpha(2)-adrenergic receptors in the modulation of glucose and lipid metabolism in the SHROB model of metabolic syndrome X.
    Annals of the New York Academy of Sciences, 2003, Volume: 1009

    Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Disease Models, Animal; Female; Glucagon; Glucose; Glucose Tolerance Test; Humans; Imidazoles; Imidazoline Receptors; Lipid Metabolism; Male; Metabolic Syndrome; Obesity; Oxazoles; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Yohimbine

2003
Sympathoadrenal function in patients with paroxysmal hypertension: pseudopheochromocytoma.
    Journal of hypertension, 2007, Volume: 25, Issue:11

    Topics: Adrenal Glands; Adult; Baroreflex; Blood Pressure Monitoring, Ambulatory; Epinephrine; Female; Glucagon; Humans; Hypertension; Isoproterenol; Male; Middle Aged; Norepinephrine; Panic Disorder; Pheochromocytoma; Positron-Emission Tomography; Sympathetic Nervous System; Trimethaphan; Yohimbine

2007
Generalized and neurotransmitter-selective noradrenergic denervation in Parkinson's disease with orthostatic hypotension.
    Movement disorders : official journal of the Movement Disorder Society, 2008, Sep-15, Volume: 23, Issue:12

    Topics: Aged; Blood Pressure; Bradycardia; Cholinesterase Inhibitors; Edrophonium; Epinephrine; Female; Glucagon; Humans; Hypotension, Orthostatic; Isoproterenol; Male; Methoxyhydroxyphenylglycol; Microdialysis; Middle Aged; Muscle, Skeletal; Norepinephrine; Parkinson Disease; Pure Autonomic Failure; Tyramine; Yohimbine

2008
Neuronal source of plasma dopamine.
    Clinical chemistry, 2008, Volume: 54, Issue:11

    Topics: Case-Control Studies; Dizziness; Dopamine; Exocytosis; Glucagon; Humans; Isoproterenol; Neurodegenerative Diseases; Neurons; Yohimbine

2008