Page last updated: 2024-09-04

glucagon and wortmannin

glucagon has been researched along with wortmannin in 22 studies

Compound Research Comparison

Studies
(glucagon)
Trials
(glucagon)
Recent Studies (post-2010)
(glucagon)
Studies
(wortmannin)
Trials
(wortmannin)
Recent Studies (post-2010) (wortmannin)
26,0391,4983,0544,0662726

Protein Interaction Comparison

ProteinTaxonomyglucagon (IC50)wortmannin (IC50)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformHomo sapiens (human)0.0465
Myosin light chain kinase, smooth muscleGallus gallus (chicken)0.26
Metabotropic glutamate receptor 1Rattus norvegicus (Norway rat)0.0085
Phosphatidylinositol 3-kinase regulatory subunit alphaHomo sapiens (human)0.2368
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformHomo sapiens (human)0.1309
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformHomo sapiens (human)0.0493
Serine/threonine-protein kinase mTORHomo sapiens (human)0.04
Phosphatidylinositol 4-kinase alphaHomo sapiens (human)0.28
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (human)0.0492
Serine/threonine-protein kinase PLK1Homo sapiens (human)0.4433
Myosin light chain kinase, smooth muscleHomo sapiens (human)2.3567
Phosphoinositide 3-kinase regulatory subunit 5Homo sapiens (human)0.019
Serine/threonine-protein kinase PLK3Homo sapiens (human)0.1057
Phosphatidylinositol 4-kinase betaHomo sapiens (human)0.44

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (36.36)18.2507
2000's14 (63.64)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Band, CJ; Posner, BI1
Beattie, GM; Cirulli, V; Hayek, A; Lopez, A; Mally, MI; Ptasznik, A1
Blommaart, EF; Luiken, JJ; Meijer, AJ1
Beavo, JA; Bornfeldt, KE; Zhao, AZ1
Lu, D; Saito, I; Shibata, H; Takeuchi, T; Tamemoto, H1
Araki, E; Kaneko, K; Kishikawa, H; Matsumoto, K; Motoshima, H; Shichiri, M; Shirotani, T; Taguchi, T; Yoshizato, K1
Buteau, J; Prentki, M; Roduit, R; Susini, S1
Novak, RF; Woodcroft, KJ1
Adrian, TE; Ding, XZ; Fehsenfeld, DM; Murphy, LO; Permert, J1
Christ, B; Granner, DK; Rucktäschel, AK1
Candelaria, RP; Keembiyehetty, CN; Majumdar, G; Martinez-Hernandez, A; Raghow, R; Solomon, SS1
Cahoy, JD; Heit, JJ; Hori, Y; Kim, SK; Rulifson, IC; Tsai, BC1
Lee, JW; Romsos, DR; Swick, AG1
El-kholy, W; MacDonald, PE; Targonsky, ED; Tsushima, RG; Wang, X; Wheeler, MB; Xia, F1
Acitores, A; González, N; Sancho, V; Valverde, I; Villanueva-Peñacarrillo, ML2
Jimenez-Feltstrom, J; Lundquist, I; Obermuller, S; Salehi, A1
Chen, J; Ostenson, CG1
Carreras, FI; Gradilone, SA; Lehmann, GL; Marinelli, RA1
Ahmed, I; Diamant, NE; Gaisano, HY; Gao, X; Hara, M; Leung, YM; Sheu, L; Tsushima, RG1
Dumas, V; Mounier, C; Posner, BI1
Asai, M; Higuchi, S; Hirano, K; Iguchi, K; Kubota, M; Usui, S1

Other Studies

22 other study(ies) available for glucagon and wortmannin

ArticleYear
Phosphatidylinositol 3'-kinase and p70s6k are required for insulin but not bisperoxovanadium 1,10-phenanthroline (bpV(phen)) inhibition of insulin-like growth factor binding protein gene expression. Evidence for MEK-independent activation of mitogen-activ
    The Journal of biological chemistry, 1997, Jan-03, Volume: 272, Issue:1

    Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dexamethasone; Enzyme Activation; Enzyme Inhibitors; Glucagon; Insulin; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor Binding Protein 4; Liver; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Organometallic Compounds; Phenanthrolines; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Polyenes; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; RNA, Messenger; Signal Transduction; Sirolimus; Wortmannin

1997
Phosphatidylinositol 3-kinase is a negative regulator of cellular differentiation.
    The Journal of cell biology, 1997, Jun-02, Volume: 137, Issue:5

    Topics: Androstadienes; Cell Differentiation; Cell Division; Chromones; DNA; Enzyme Inhibitors; Fetus; Glucagon; Hepatocyte Growth Factor; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Morpholines; Niacinamide; Pancreas; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Somatostatin; Wortmannin

1997
Regulation of hepatic protein degradation.
    Contributions to nephrology, 1997, Volume: 121

    Topics: Amino Acids; Androstadienes; Animals; Autophagy; Cells, Cultured; Chromones; Enzyme Inhibitors; Food Deprivation; Glucagon; Insulin; Liver; Male; Morpholines; Phosphates; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Polyenes; Proteins; Rats; Rats, Wistar; Ribosomal Protein S6; Ribosomal Protein S6 Kinases; Ribosomal Proteins; Sirolimus; Sucrose; Wortmannin

1997
Leptin inhibits insulin secretion by activation of phosphodiesterase 3B.
    The Journal of clinical investigation, 1998, Sep-01, Volume: 102, Issue:5

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Androstadienes; Animals; Cell Line; Chromones; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Enzyme Activation; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Leptin; Morpholines; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Protein Precursors; Proteins; Pyrrolidinones; Rats; Rolipram; Signal Transduction; Wortmannin

1998
Regulatable production of insulin from primary-cultured hepatocytes: insulin production is up-regulated by glucagon and cAMP and down-regulated by insulin.
    Gene therapy, 1998, Volume: 5, Issue:7

    Topics: 1-Methyl-3-isobutylxanthine; Adenoviridae; Androstadienes; Animals; Cells, Cultured; Cyclic AMP; Gene Expression Regulation; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Glucagon; Insulin; Insulin Antagonists; Liver; Male; Phosphoenolpyruvate Carboxykinase (GTP); Proinsulin; Rats; Rats, Wistar; Wortmannin

1998
Insulin inhibits glucagon secretion by the activation of PI3-kinase in In-R1-G9 cells.
    Diabetes research and clinical practice, 1999, Volume: 44, Issue:2

    Topics: Androstadienes; Animals; Cell Line; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Glucagon; Insulin; Insulin Receptor Substrate Proteins; Islets of Langerhans; Kinetics; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Time Factors; Wortmannin

1999
Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells.
    Diabetologia, 1999, Volume: 42, Issue:7

    Topics: Androstadienes; Animals; Chromones; DNA; DNA-Binding Proteins; Duodenum; Enzyme Activation; Enzyme Inhibitors; Genes, Homeobox; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Islets of Langerhans; Morpholines; Nifedipine; Pancreas; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Potassium Chloride; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Transcription Factor AP-1; Transcription Factors; Tumor Cells, Cultured; Wortmannin

1999
The role of phosphatidylinositol 3-kinase, Src kinase, and protein kinase A signaling pathways in insulin and glucagon regulation of CYP2E1 expression.
    Biochemical and biophysical research communications, 1999, Dec-20, Volume: 266, Issue:2

    Topics: Androstadienes; Animals; Benzoquinones; Bucladesine; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cytochrome P-450 CYP2E1; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Glucagon; Insulin; Lactams, Macrocyclic; Liver; Male; Phosphatidylinositol 3-Kinases; Quinones; Rats; RNA, Messenger; Signal Transduction; src-Family Kinases; Wortmannin

1999
Physiological concentrations of insulin augment pancreatic cancer cell proliferation and glucose utilization by activating MAP kinase, PI3 kinase and enhancing GLUT-1 expression.
    Pancreas, 2000, Volume: 21, Issue:3

    Topics: Androstadienes; Cell Division; DNA, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glucagon; Glucose; Glucose Transporter Type 1; Humans; Insulin; Mitogen-Activated Protein Kinases; Monosaccharide Transport Proteins; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinases; Somatostatin; Tumor Cells, Cultured; Wortmannin

2000
Regulation by glucagon (cAMP) and insulin of the promoter of the human phosphoenolpyruvate carboxykinase gene (cytosolic) in cultured rat hepatocytes and in human hepatoblastoma cells.
    The Biochemical journal, 2000, Nov-15, Volume: 352 Pt 1

    Topics: Androstadienes; Animals; Cells, Cultured; Cloning, Molecular; Cyclic AMP; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glucagon; Hepatoblastoma; Humans; Insulin; Liver; Luciferases; Male; Phosphatidylinositol 3-Kinases; Phosphoenolpyruvate Carboxykinase (GTP); Plasmids; Promoter Regions, Genetic; Rats; Rats, Wistar; Transfection; Transgenes; Tumor Cells, Cultured; Wortmannin

2000
Paradoxical regulation of Sp1 transcription factor by glucagon.
    Endocrinology, 2002, Volume: 143, Issue:4

    Topics: Androstadienes; Animals; Calmodulin; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Gene Expression Regulation; Glucagon; Hypoglycemic Agents; Immunoblotting; Immunohistochemistry; Insulin; Insulin Antagonists; Rats; Receptors, Cell Surface; RNA, Messenger; Signal Transduction; Sp1 Transcription Factor; Time Factors; Tumor Necrosis Factor-alpha; Wortmannin

2002
Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells.
    Proceedings of the National Academy of Sciences of the United States of America, 2002, Dec-10, Volume: 99, Issue:25

    Topics: Androstadienes; Animals; Biomarkers; Cell Aggregation; Cell Differentiation; Cell Line; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Embryo, Mammalian; Enzyme Inhibitors; Glucagon; Growth Inhibitors; Homeostasis; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasms, Experimental; Niacinamide; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Stem Cell Transplantation; Stem Cells; Streptozocin; Weight Loss; Wortmannin

2002
Leptin constrains phospholipase C-protein kinase C-induced insulin secretion via a phosphatidylinositol 3-kinase-dependent pathway.
    Experimental biology and medicine (Maywood, N.J.), 2003, Volume: 228, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Androstadienes; Animals; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Leptin; Mice; Mice, Inbred C57BL; Mice, Knockout; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Precursors; Signal Transduction; Type C Phospholipases; Wortmannin

2003
Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways.
    The Journal of biological chemistry, 2003, Dec-26, Volume: 278, Issue:52

    Topics: Androstadienes; Animals; Blotting, Western; Catalysis; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Kinetics; Male; Mice; Peptide Fragments; Peptides; Phosphatidylinositol 3-Kinases; Phosphorylation; Potassium; Precipitin Tests; Protein Precursors; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Time Factors; Transcriptional Activation; Tyrphostins; Up-Regulation; Venoms; Wortmannin

2003
Cell signalling of glucagon-like peptide-1 action in rat skeletal muscle.
    The Journal of endocrinology, 2004, Volume: 180, Issue:3

    Topics: Androstadienes; Animals; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glucagon; Glucagon-Like Peptide 1; Glycogen Synthase; In Vitro Techniques; Indoles; Insulin; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Okadaic Acid; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Precursors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Tumor Necrosis Factor-alpha; Wortmannin

2004
Insulin feedback actions: complex effects involving isoforms of islet nitric oxide synthase.
    Regulatory peptides, 2004, Oct-15, Volume: 122, Issue:2

    Topics: Androstadienes; Animals; C-Peptide; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Feedback, Physiological; Female; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Isoenzymes; Mice; Microscopy, Confocal; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Precursors; Wortmannin

2004
Glucagon release is regulated by tyrosine phosphatase and PI3-kinase activity.
    Biochemical and biophysical research communications, 2004, Dec-10, Volume: 325, Issue:2

    Topics: Androstadienes; Animals; Arginine; Cell Line, Tumor; Cricetinae; Enzyme Inhibitors; Glucagon; Glucagonoma; Hypoglycemic Agents; Immunoprecipitation; Insulin; Insulin Secretion; Male; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Tyrosine Phosphatases; Rats; Rats, Inbred Strains; Rats, Wistar; Signal Transduction; Vanadates; Wortmannin

2004
Effect of GLP-1 on glucose transport and its cell signalling in human myocytes.
    Regulatory peptides, 2005, Mar-30, Volume: 126, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Aged, 80 and over; Androstadienes; Biological Transport; Cells, Cultured; Enzyme Activation; Exenatide; Female; Flavonoids; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Indoles; Insulin; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle Cells; Peptide Fragments; Peptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Precursors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Venoms; Wortmannin

2005
Phosphoinositide 3-kinase is involved in the glucagon-induced translocation of aquaporin-8 to hepatocyte plasma membrane.
    Biology of the cell, 2005, Volume: 97, Issue:11

    Topics: Androstadienes; Animals; Aquaporins; Cell Membrane; Cell Membrane Permeability; Chromones; Glucagon; Hepatocytes; Ion Channels; Male; Morpholines; Phosphatidylinositol 3-Kinases; Protein Transport; Rats; Rats, Wistar; Wortmannin

2005
Insulin regulates islet alpha-cell function by reducing KATP channel sensitivity to adenosine 5'-triphosphate inhibition.
    Endocrinology, 2006, Volume: 147, Issue:5

    Topics: Adenosine Triphosphate; Androstadienes; Animals; Body Weight; Cell Line; Diabetes Mellitus; Dose-Response Relationship, Drug; Glucagon; Glucagon-Secreting Cells; Glucose; Glutamic Acid; Green Fluorescent Proteins; Guinea Pigs; Humans; Inhibitory Concentration 50; Insulin; Islets of Langerhans; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Phosphatidylinositol 3-Kinases; Potassium; Rabbits; Signal Transduction; Wortmannin

2006
Regulation of hepatic insulin-like growth factor-binding protein-1 gene expression by insulin: central role for mammalian target of rapamycin independent of forkhead box O proteins.
    Endocrinology, 2006, Volume: 147, Issue:5

    Topics: Androstadienes; Animals; Blotting, Western; Cells, Cultured; Dexamethasone; Dose-Response Relationship, Drug; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Expression Regulation; Genes, Dominant; Glucagon; Hepatocytes; Insulin; Insulin-Like Growth Factor Binding Protein 1; Liver; Male; Nerve Tissue Proteins; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; RNA; RNA, Messenger; Signal Transduction; Swine; Time Factors; TOR Serine-Threonine Kinases; Wortmannin

2006
Regulators for blood glucose level affect gene expression of aquaporin 3.
    Biological & pharmaceutical bulletin, 2006, Volume: 29, Issue:5

    Topics: Actins; Androstadienes; Aquaporin 3; Biguanides; Blood Glucose; Blotting, Western; Caco-2 Cells; Chromans; Epinephrine; Gene Expression; Glucagon; Humans; Hypoglycemic Agents; Insulin; Insulin Antagonists; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Thiazolidinediones; Tolbutamide; Troglitazone; Wortmannin

2006