glucagon has been researched along with wortmannin in 22 studies
| Studies (glucagon) | Trials (glucagon) | Recent Studies (post-2010) (glucagon) | Studies (wortmannin) | Trials (wortmannin) | Recent Studies (post-2010) (wortmannin) |
|---|---|---|---|---|---|
| 26,039 | 1,498 | 3,054 | 4,066 | 2 | 726 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (36.36) | 18.2507 |
| 2000's | 14 (63.64) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Band, CJ; Posner, BI | 1 |
| Beattie, GM; Cirulli, V; Hayek, A; Lopez, A; Mally, MI; Ptasznik, A | 1 |
| Blommaart, EF; Luiken, JJ; Meijer, AJ | 1 |
| Beavo, JA; Bornfeldt, KE; Zhao, AZ | 1 |
| Lu, D; Saito, I; Shibata, H; Takeuchi, T; Tamemoto, H | 1 |
| Araki, E; Kaneko, K; Kishikawa, H; Matsumoto, K; Motoshima, H; Shichiri, M; Shirotani, T; Taguchi, T; Yoshizato, K | 1 |
| Buteau, J; Prentki, M; Roduit, R; Susini, S | 1 |
| Novak, RF; Woodcroft, KJ | 1 |
| Adrian, TE; Ding, XZ; Fehsenfeld, DM; Murphy, LO; Permert, J | 1 |
| Christ, B; Granner, DK; Rucktäschel, AK | 1 |
| Candelaria, RP; Keembiyehetty, CN; Majumdar, G; Martinez-Hernandez, A; Raghow, R; Solomon, SS | 1 |
| Cahoy, JD; Heit, JJ; Hori, Y; Kim, SK; Rulifson, IC; Tsai, BC | 1 |
| Lee, JW; Romsos, DR; Swick, AG | 1 |
| El-kholy, W; MacDonald, PE; Targonsky, ED; Tsushima, RG; Wang, X; Wheeler, MB; Xia, F | 1 |
| Acitores, A; González, N; Sancho, V; Valverde, I; Villanueva-Peñacarrillo, ML | 2 |
| Jimenez-Feltstrom, J; Lundquist, I; Obermuller, S; Salehi, A | 1 |
| Chen, J; Ostenson, CG | 1 |
| Carreras, FI; Gradilone, SA; Lehmann, GL; Marinelli, RA | 1 |
| Ahmed, I; Diamant, NE; Gaisano, HY; Gao, X; Hara, M; Leung, YM; Sheu, L; Tsushima, RG | 1 |
| Dumas, V; Mounier, C; Posner, BI | 1 |
| Asai, M; Higuchi, S; Hirano, K; Iguchi, K; Kubota, M; Usui, S | 1 |
22 other study(ies) available for glucagon and wortmannin
| Article | Year |
|---|---|
Phosphatidylinositol 3'-kinase and p70s6k are required for insulin but not bisperoxovanadium 1,10-phenanthroline (bpV(phen)) inhibition of insulin-like growth factor binding protein gene expression. Evidence for MEK-independent activation of mitogen-activ
Topics: Androstadienes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dexamethasone; Enzyme Activation; Enzyme Inhibitors; Glucagon; Insulin; Insulin-Like Growth Factor Binding Protein 1; Insulin-Like Growth Factor Binding Protein 4; Liver; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Organometallic Compounds; Phenanthrolines; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Polyenes; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; RNA, Messenger; Signal Transduction; Sirolimus; Wortmannin | 1997 |
Phosphatidylinositol 3-kinase is a negative regulator of cellular differentiation.
Topics: Androstadienes; Cell Differentiation; Cell Division; Chromones; DNA; Enzyme Inhibitors; Fetus; Glucagon; Hepatocyte Growth Factor; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Morpholines; Niacinamide; Pancreas; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Somatostatin; Wortmannin | 1997 |
Regulation of hepatic protein degradation.
Topics: Amino Acids; Androstadienes; Animals; Autophagy; Cells, Cultured; Chromones; Enzyme Inhibitors; Food Deprivation; Glucagon; Insulin; Liver; Male; Morpholines; Phosphates; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Polyenes; Proteins; Rats; Rats, Wistar; Ribosomal Protein S6; Ribosomal Protein S6 Kinases; Ribosomal Proteins; Sirolimus; Sucrose; Wortmannin | 1997 |
Leptin inhibits insulin secretion by activation of phosphodiesterase 3B.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Androstadienes; Animals; Cell Line; Chromones; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Enzyme Activation; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Leptin; Morpholines; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Protein Precursors; Proteins; Pyrrolidinones; Rats; Rolipram; Signal Transduction; Wortmannin | 1998 |
Regulatable production of insulin from primary-cultured hepatocytes: insulin production is up-regulated by glucagon and cAMP and down-regulated by insulin.
Topics: 1-Methyl-3-isobutylxanthine; Adenoviridae; Androstadienes; Animals; Cells, Cultured; Cyclic AMP; Gene Expression Regulation; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Glucagon; Insulin; Insulin Antagonists; Liver; Male; Phosphoenolpyruvate Carboxykinase (GTP); Proinsulin; Rats; Rats, Wistar; Wortmannin | 1998 |
Insulin inhibits glucagon secretion by the activation of PI3-kinase in In-R1-G9 cells.
Topics: Androstadienes; Animals; Cell Line; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Glucagon; Insulin; Insulin Receptor Substrate Proteins; Islets of Langerhans; Kinetics; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Time Factors; Wortmannin | 1999 |
Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells.
Topics: Androstadienes; Animals; Chromones; DNA; DNA-Binding Proteins; Duodenum; Enzyme Activation; Enzyme Inhibitors; Genes, Homeobox; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Islets of Langerhans; Morpholines; Nifedipine; Pancreas; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Potassium Chloride; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Transcription Factor AP-1; Transcription Factors; Tumor Cells, Cultured; Wortmannin | 1999 |
The role of phosphatidylinositol 3-kinase, Src kinase, and protein kinase A signaling pathways in insulin and glucagon regulation of CYP2E1 expression.
Topics: Androstadienes; Animals; Benzoquinones; Bucladesine; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cytochrome P-450 CYP2E1; Enzyme Inhibitors; Flavonoids; Gene Expression Regulation, Enzymologic; Glucagon; Insulin; Lactams, Macrocyclic; Liver; Male; Phosphatidylinositol 3-Kinases; Quinones; Rats; RNA, Messenger; Signal Transduction; src-Family Kinases; Wortmannin | 1999 |
Physiological concentrations of insulin augment pancreatic cancer cell proliferation and glucose utilization by activating MAP kinase, PI3 kinase and enhancing GLUT-1 expression.
Topics: Androstadienes; Cell Division; DNA, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glucagon; Glucose; Glucose Transporter Type 1; Humans; Insulin; Mitogen-Activated Protein Kinases; Monosaccharide Transport Proteins; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinases; Somatostatin; Tumor Cells, Cultured; Wortmannin | 2000 |
Regulation by glucagon (cAMP) and insulin of the promoter of the human phosphoenolpyruvate carboxykinase gene (cytosolic) in cultured rat hepatocytes and in human hepatoblastoma cells.
Topics: Androstadienes; Animals; Cells, Cultured; Cloning, Molecular; Cyclic AMP; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glucagon; Hepatoblastoma; Humans; Insulin; Liver; Luciferases; Male; Phosphatidylinositol 3-Kinases; Phosphoenolpyruvate Carboxykinase (GTP); Plasmids; Promoter Regions, Genetic; Rats; Rats, Wistar; Transfection; Transgenes; Tumor Cells, Cultured; Wortmannin | 2000 |
Paradoxical regulation of Sp1 transcription factor by glucagon.
Topics: Androstadienes; Animals; Calmodulin; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Gene Expression Regulation; Glucagon; Hypoglycemic Agents; Immunoblotting; Immunohistochemistry; Insulin; Insulin Antagonists; Rats; Receptors, Cell Surface; RNA, Messenger; Signal Transduction; Sp1 Transcription Factor; Time Factors; Tumor Necrosis Factor-alpha; Wortmannin | 2002 |
Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells.
Topics: Androstadienes; Animals; Biomarkers; Cell Aggregation; Cell Differentiation; Cell Line; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Embryo, Mammalian; Enzyme Inhibitors; Glucagon; Growth Inhibitors; Homeostasis; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Mice, Inbred NOD; Mice, SCID; Neoplasms, Experimental; Niacinamide; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Stem Cell Transplantation; Stem Cells; Streptozocin; Weight Loss; Wortmannin | 2002 |
Leptin constrains phospholipase C-protein kinase C-induced insulin secretion via a phosphatidylinositol 3-kinase-dependent pathway.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Androstadienes; Animals; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Leptin; Mice; Mice, Inbred C57BL; Mice, Knockout; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Precursors; Signal Transduction; Type C Phospholipases; Wortmannin | 2003 |
Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways.
Topics: Androstadienes; Animals; Blotting, Western; Catalysis; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Kinetics; Male; Mice; Peptide Fragments; Peptides; Phosphatidylinositol 3-Kinases; Phosphorylation; Potassium; Precipitin Tests; Protein Precursors; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Time Factors; Transcriptional Activation; Tyrphostins; Up-Regulation; Venoms; Wortmannin | 2003 |
Cell signalling of glucagon-like peptide-1 action in rat skeletal muscle.
Topics: Androstadienes; Animals; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glucagon; Glucagon-Like Peptide 1; Glycogen Synthase; In Vitro Techniques; Indoles; Insulin; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Okadaic Acid; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Precursors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Tumor Necrosis Factor-alpha; Wortmannin | 2004 |
Insulin feedback actions: complex effects involving isoforms of islet nitric oxide synthase.
Topics: Androstadienes; Animals; C-Peptide; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Feedback, Physiological; Female; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Isoenzymes; Mice; Microscopy, Confocal; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Precursors; Wortmannin | 2004 |
Glucagon release is regulated by tyrosine phosphatase and PI3-kinase activity.
Topics: Androstadienes; Animals; Arginine; Cell Line, Tumor; Cricetinae; Enzyme Inhibitors; Glucagon; Glucagonoma; Hypoglycemic Agents; Immunoprecipitation; Insulin; Insulin Secretion; Male; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Tyrosine Phosphatases; Rats; Rats, Inbred Strains; Rats, Wistar; Signal Transduction; Vanadates; Wortmannin | 2004 |
Effect of GLP-1 on glucose transport and its cell signalling in human myocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Aged, 80 and over; Androstadienes; Biological Transport; Cells, Cultured; Enzyme Activation; Exenatide; Female; Flavonoids; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Indoles; Insulin; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle Cells; Peptide Fragments; Peptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Precursors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Venoms; Wortmannin | 2005 |
Phosphoinositide 3-kinase is involved in the glucagon-induced translocation of aquaporin-8 to hepatocyte plasma membrane.
Topics: Androstadienes; Animals; Aquaporins; Cell Membrane; Cell Membrane Permeability; Chromones; Glucagon; Hepatocytes; Ion Channels; Male; Morpholines; Phosphatidylinositol 3-Kinases; Protein Transport; Rats; Rats, Wistar; Wortmannin | 2005 |
Insulin regulates islet alpha-cell function by reducing KATP channel sensitivity to adenosine 5'-triphosphate inhibition.
Topics: Adenosine Triphosphate; Androstadienes; Animals; Body Weight; Cell Line; Diabetes Mellitus; Dose-Response Relationship, Drug; Glucagon; Glucagon-Secreting Cells; Glucose; Glutamic Acid; Green Fluorescent Proteins; Guinea Pigs; Humans; Inhibitory Concentration 50; Insulin; Islets of Langerhans; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Phosphatidylinositol 3-Kinases; Potassium; Rabbits; Signal Transduction; Wortmannin | 2006 |
Regulation of hepatic insulin-like growth factor-binding protein-1 gene expression by insulin: central role for mammalian target of rapamycin independent of forkhead box O proteins.
Topics: Androstadienes; Animals; Blotting, Western; Cells, Cultured; Dexamethasone; Dose-Response Relationship, Drug; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Expression Regulation; Genes, Dominant; Glucagon; Hepatocytes; Insulin; Insulin-Like Growth Factor Binding Protein 1; Liver; Male; Nerve Tissue Proteins; Okadaic Acid; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; RNA; RNA, Messenger; Signal Transduction; Swine; Time Factors; TOR Serine-Threonine Kinases; Wortmannin | 2006 |
Regulators for blood glucose level affect gene expression of aquaporin 3.
Topics: Actins; Androstadienes; Aquaporin 3; Biguanides; Blood Glucose; Blotting, Western; Caco-2 Cells; Chromans; Epinephrine; Gene Expression; Glucagon; Humans; Hypoglycemic Agents; Insulin; Insulin Antagonists; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Thiazolidinediones; Tolbutamide; Troglitazone; Wortmannin | 2006 |