Compounds > glucagon
Page last updated: 2024-09-04

glucagon and rolipram

glucagon has been researched along with rolipram in 5 studies

Compound Research Comparison

Studies
(glucagon)		Trials
(glucagon)		Recent Studies (post-2010)
(glucagon)		Studies
(rolipram)		Trials
(rolipram)		Recent Studies (post-2010) (rolipram)
26,0391,4983,0541,60417401

Protein Interaction Comparison

ProteinTaxonomyglucagon (IC50)rolipram (IC50)
cGMP-dependent 3',5'-cyclic phosphodiesteraseHomo sapiens (human)1.2233
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8AHomo sapiens (human)1.2233
Retina-specific copper amine oxidaseHomo sapiens (human)0.0003
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)1.0975
3',5'-cyclic-AMP phosphodiesterase Sus scrofa (pig)3.63
ReninHomo sapiens (human)3.5
Tumor necrosis factorHomo sapiens (human)0.35
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Rattus norvegicus (Norway rat)0.7287
cAMP-specific 3',5'-cyclic phosphodiesterase 4CRattus norvegicus (Norway rat)0.7287
cAMP-specific 3',5'-cyclic phosphodiesterase 4BRattus norvegicus (Norway rat)0.8447
cAMP-specific 3',5'-cyclic phosphodiesterase 4AHomo sapiens (human)1.1942
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)0.095
Delta-type opioid receptorMus musculus (house mouse)1.5
Delta-type opioid receptorRattus norvegicus (Norway rat)1.5
cAMP-specific 3',5'-cyclic phosphodiesterase 4ARattus norvegicus (Norway rat)0.7287
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BHomo sapiens (human)0.835
cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)1.1005
cAMP-specific 3',5'-cyclic phosphodiesterase 4CHomo sapiens (human)1.61
cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)1.0794
cGMP-inhibited 3',5'-cyclic phosphodiesterase BHomo sapiens (human)0.835
cGMP-inhibited 3',5'-cyclic phosphodiesterase AHomo sapiens (human)2
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11AHomo sapiens (human)0.835
cAMP-specific 3',5'-cyclic phosphodiesterase 7BHomo sapiens (human)0.835
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AHomo sapiens (human)0.835

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (80.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Absood, A; Chen, D; Håkanson, R1
Azizeh, BY; Houslay, MD; Hruby, VJ; Johnson, DG; Phelps, JR; Trivedi, D; Van Tine, BA1
Azizeh, BY; Hruby, VJ; Trivedi, D; Van Tine, BA1
Beavo, JA; Bornfeldt, KE; Zhao, AZ1
Hernández Cascales, J; Juan-Fita, MJ; Kaumann, AJ; Vargas, ML1

Other Studies

5 other study(ies) available for glucagon and rolipram

ArticleYear
Neuropeptides of the vasoactive intestinal peptide/helodermin/pituitary adenylate cyclase activating peptide family elevate plasma cAMP in mice: comparison with a range of other regulatory peptides.
    Regulatory peptides, 1992, Aug-13, Volume: 40, Issue:3

    Topics: Animals; Calcitonin; Calcitonin Gene-Related Peptide; Colforsin; Cyclic AMP; Drug Interactions; Glucagon; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Mice; Neuropeptides; Parathyroid Hormone; Peptides; Phosphodiesterase Inhibitors; Pyrrolidinones; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Rolipram; Tail; Vasoactive Intestinal Peptide

1992
Low level cyclic adenosine 3',5'-monophosphate accumulation analysis of [des-His1, des- Phe6, Glu9] glucagon-NH2 identifies glucagon antagonists from weak partial agonists/antagonists.
    Endocrinology, 1996, Volume: 137, Issue:8

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Amrinone; Animals; Blood Glucose; Cyclic AMP; Diabetes Mellitus, Experimental; Glucagon; Liver; Male; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Rolipram

1996
Pure glucagon antagonists: biological activities and cAMP accumulation using phosphodiesterase inhibitors.
    Peptides, 1997, Volume: 18, Issue:5

    Topics: Adenylyl Cyclases; Animals; Cattle; Cyclic AMP; Glucagon; Humans; Liver; Male; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Rolipram; Sensitivity and Specificity

1997
Leptin inhibits insulin secretion by activation of phosphodiesterase 3B.
    The Journal of clinical investigation, 1998, Sep-01, Volume: 102, Issue:5

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Androstadienes; Animals; Cell Line; Chromones; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Enzyme Activation; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Leptin; Morpholines; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Protein Precursors; Proteins; Pyrrolidinones; Rats; Rolipram; Signal Transduction; Wortmannin

1998
Rolipram reduces the inotropic tachyphylaxis of glucagon in rat ventricular myocardium.
    Naunyn-Schmiedeberg's archives of pharmacology, 2004, Volume: 370, Issue:4

    Topics: Animals; Cardiotonic Agents; Dose-Response Relationship, Drug; Female; Glucagon; Heart Ventricles; In Vitro Techniques; Male; Myocardial Contraction; Rats; Rats, Sprague-Dawley; Rolipram; Tachyphylaxis; Ventricular Function

2004