Compounds > glucagon
Page last updated: 2024-09-04

glucagon and glutamic acid

glucagon has been researched along with glutamic acid in 48 studies

Compound Research Comparison

Studies
(glucagon)		Trials
(glucagon)		Recent Studies (post-2010)
(glucagon)		Studies
(glutamic acid)		Trials
(glutamic acid)		Recent Studies (post-2010) (glutamic acid)
26,0391,4983,05441,75745212,876

Protein Interaction Comparison

ProteinTaxonomyglucagon (IC50)glutamic acid (IC50)
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2Rattus norvegicus (Norway rat)0.821
Chain A, Glutamate Receptor Subunit 2Rattus norvegicus (Norway rat)0.821
Chain B, Glutamate Receptor Subunit 2Rattus norvegicus (Norway rat)0.821
Metabotropic glutamate receptor 8Homo sapiens (human)0.0057
Glutamate receptor ionotropic, NMDA 2DHomo sapiens (human)0.07
Glutamate receptor ionotropic, NMDA 3BHomo sapiens (human)0.07
Glutamate receptor 1Rattus norvegicus (Norway rat)0.5885
Glutamate receptor 2Rattus norvegicus (Norway rat)0.5885
Glutamate receptor 3Rattus norvegicus (Norway rat)0.5885
Glutamate receptor 4Rattus norvegicus (Norway rat)0.5885
Glutamate receptor ionotropic, kainate 1Rattus norvegicus (Norway rat)0.38
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)0.1533
Glutamate receptor ionotropic, kainate 2Rattus norvegicus (Norway rat)0.38
Glutamate receptor 1Homo sapiens (human)0.613
Glutamate receptor 2Homo sapiens (human)0.613
Glutamate receptor 3Homo sapiens (human)0.613
Glutamate receptor ionotropic, kainate 3Rattus norvegicus (Norway rat)0.38
Excitatory amino acid transporter 1Homo sapiens (human)207
Glutamate receptor 4Homo sapiens (human)0.613
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)0.1533
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)0.1533
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)0.1533
Glutamate receptor ionotropic, kainate 4Rattus norvegicus (Norway rat)0.38
Glutamate receptor ionotropic, NMDA 1Homo sapiens (human)0.07
Glutamate receptor ionotropic, NMDA 2AHomo sapiens (human)0.07
Glutamate receptor ionotropic, NMDA 2BHomo sapiens (human)0.07
Glutamate receptor ionotropic, NMDA 2CHomo sapiens (human)0.07
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)0.1533
Glutamate receptor ionotropic, kainate 5Rattus norvegicus (Norway rat)0.38
Glutamate receptor ionotropic, NMDA 3AHomo sapiens (human)0.07
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)0.1533
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)0.1533

Research

Studies (48)

TimeframeStudies, this research(%)All Research%
pre-19907 (14.58)18.7374
1990's10 (20.83)18.2507
2000's19 (39.58)29.6817
2010's10 (20.83)24.3611
2020's2 (4.17)2.80

Authors

AuthorsStudies
D'Souza, NB; Deaciuc, IV; Lang, CH; Spitzer, JJ1
Hreniuk, S; LaNoue, KF; Scaduto, RC; Sterniczuk, A1
Breddam, K; Sørensen, SB; Sørensen, TL1
Battelli, D; Bellei, M; Bobyleva-Guarriero, V; Lardy, HA1
Koch, CD; LaNoue, KF; Strzelecka, D; Strzelecki, T1
Goldman, SS1
Hamman, HC; Haynes, RC1
McGivan, JD; Staddon, JM1
Bradford, NM; McGivan, JD; Staddon, JM1
Fahimi, FM; Kientsch-Engel, RI; Siess, EA; Wieland, OH1
Le Floc'h, N; Obled, C; Sève, B1
Brosnan, JT; Ewart, HS; Squires, SA1
Bertrand, G; Bockaert, J; Gross, R; Loubatières-Mariani, MM; Puech, R1
Alvarsson, M; Efendic, S; Glaser, A; Grill, V; Luthman, H; Wajngot, A1
Brubaker, PL; Stobie-Hayes, KM1
Beylot, M; Brunengraber, H; Large, V; Odeon, M1
Goto, N; Kameyama, T; Oka, JI1
Kirchgessner, AL; Ouedraogo, R; Tong, Q1
Egan, JM; Greig, NH; Haughey, NJ; Mattson, MP; Perry, T1
Fritsche, A; Häring, H; Holzwarth, M; Machicao, F; Maerker, E; Stumvoll, M; Teigeler, A; Tschritter, O; Weisser, M1
Hayashi, M; Morimoto, R; Moriyama, Y; Muroyama, A; Takeda, J; Uehara, S; Yamada, H; Yamamoto, A; Yatsushiro, S1
Brauner-Osborne, H; Gram, C; Knudsen, LB; Madsen, K; Runge, S; Wulff, BS1
Greig, NH; Mattson, MP; Perry, T1
Egan, JM; Furukawa, K; Gilman, CP; Grieg, NH; Mattson, MP; Perry, T1
Bailey, CJ; Flatt, PR; Gault, VA; Green, BD; Greer, B; Harriott, P; Irwin, N; Mooney, MH; O'Harte, FP1
Echigo, N; Morimoto, R; Moriyama, Y; Muroyama, A; Otsuka, M; Uehara, S; Yatsushiro, S1
Anousis, N; Carvalho, RA; Malloy, CR; Sherry, AD; Zhao, P1
Echigo, N; Hayashi, M; Koh, DS; Morimoto, R; Morita, M; Moriyama, Y; Muroyama, A; Uehara, S; Yamamoto, A; Yatsushiro, S1
Acuna-Goycolea, C; van den Pol, A1
Choi, CY; Kim, CH; Kim, EA; Kim, HT; Kim, YH; Lee, C; Lee, SE; Noh, YT; Ryu, MJ1
Ahmed, I; Diamant, NE; Gaisano, HY; Gao, X; Hara, M; Leung, YM; Sheu, L; Tsushima, RG1
Bernroider, E; Bischof, MG; Brehm, A; Krebs, M; Krssák, M; Mlynárik, V; Roden, M1
Choi, B; Choi, CS; Christiansen, LM; Dhillon, H; Elmquist, JK; Kramer, MD; Lee, CE; Lowell, BB; McCrimmon, RJ; Sherwin, RS; Shulman, GI; Tong, Q; Yang, Z; Ye, C; Yu, J; Zigman, JM1
González-Alonso, J; Graham, TE; Mourtzakis, M; Saltin, B1
Gaisano, HY; Leung, YM1
Berggren, PO; Berman, DM; Cabrera, O; Caicedo, A; Fachado, A; Jacques-Silva, MC; Kenyon, NS; Kibbey, R; Köhler, M; Ricordi, C; Speier, S; Vieira, E; Yang, SN; Zierath, JR1
Goto, M; Inoue, M; Matsuki, H; Mohd Ismail, NI; Nagahama, M; Nambu, Y; Nisimoto, M; Tsuji, A; Yuasa, K; Yuasa, T1
Chen, L; Cho, JH; Chow, RH; Hille, B; Kim, MH; Koh, DS1
del Rio, RM; Feldmann, N; Gjinovci, A; Tamarit-Rodriguez, J; Wiederkehr, A; Wollheim, CB1
Fanne, RA; Heyman, SN; Higazi, AA; Hijazi, N; Nassar, T1
Bichovsky, Y; Boyko, M; Gruenbaum, BF; Gruenbaum, SE; Klin, Y; Kuts, R; Ohayon, S; Shapira, Y; Sheiner, E; Teichberg, VI; Zlotnik, A1
Czyzyk, J; Eid, T; Sherwin, RS; Szepietowska, B; Zhu, W1
Baloh, RH; Bouitbir, J; Dupuis, L; Eschbach, J; Fergani, A; Geny, B; Harms, MB; Larmet, Y; Loeffler, JP; Ludolph, AC; Marion, V; Messadeq, N; René, F; Schlagowski, AI; Shy, ME; Sinniger, J; Weydt, P; Zoll, J1
Luo, X; Ma, Y; Wang, H; Wang, J; Wang, X; Ye, W; Zhang, W1
Brown, LD; Hay, WW; Houin, SS; Rozance, PJ; Thorn, SR; Wilkening, RB1
Harada, N; Ikeda, K; Inagaki, N; Joo, E; Mano, F; Yamane, S1
DiMarchi, RD; Glotfelty, EJ; Greig, NH; Hoffer, BJ; Li, Y; Namdar, I; Olson, L; Pick, CG; Tweedie, D1
Hosoe, S; Ishizaka, Y; Kageyama, Y; Katakami, N; Kawamori, D; Shimomura, I; Tanaka, T1

Reviews

1 review(s) available for glucagon and glutamic acid

ArticleYear
Pancreatic islet alpha cell commands itself: secrete more glucagon!
    Cell metabolism, 2008, Volume: 7, Issue:6

    Topics: Autocrine Communication; Blood Glucose; Glucagon; Glucagon-Secreting Cells; Glutamic Acid; Humans

2008

Other Studies

47 other study(ies) available for glucagon and glutamic acid

ArticleYear
Effects of acute alcohol intoxication on gluconeogenesis and its hormonal responsiveness in isolated, perfused rat liver.
    Biochemical pharmacology, 1992, Oct-20, Volume: 44, Issue:8

    Topics: Adenine Nucleotides; Alcoholic Intoxication; Animals; Aspartic Acid; Dinoprost; Dose-Response Relationship, Drug; Ethanol; Glucagon; Gluconeogenesis; Glucose; Glutamates; Glutamic Acid; Lactates; Liver; Malates; Male; Perfusion; Phenylephrine; Pyruvates; Rats; Rats, Sprague-Dawley

1992
The mechanism of Ca2(+)-related control of gluconeogenesis in perfused liver.
    European journal of biochemistry, 1991, Feb-26, Volume: 196, Issue:1

    Topics: Animals; Aspartic Acid; Biological Transport; Calcium; Glucagon; Gluconeogenesis; Glutamates; Glutamic Acid; In Vitro Techniques; Male; Mitochondria, Liver; Oxidation-Reduction; Perfusion; Phenylephrine; Rats; Tetradecanoylphorbol Acetate

1991
Fragmentation of proteins by S. aureus strain V8 protease. Ammonium bicarbonate strongly inhibits the enzyme but does not improve the selectivity for glutamic acid.
    FEBS letters, 1991, Dec-09, Volume: 294, Issue:3

    Topics: Amino Acid Sequence; Bicarbonates; Glucagon; Glutamates; Glutamic Acid; Hydrogen-Ion Concentration; Hydrolysis; Insulin; Molecular Sequence Data; Peptides; Phosphates; Protease Inhibitors; Proteins; Serine Endopeptidases; Substrate Specificity

1991
Sources of intramitochondrial malate.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1989, Volume: 3, Issue:10

    Topics: Adrenalectomy; Alanine; Animals; Glucagon; Glutamates; Glutamic Acid; Hydrocortisone; Malates; Male; Mitochondria, Liver; Rats; Rats, Inbred Strains

1989
Sites of action of glucagon and other Ca2+ mobilizing hormones on the malate aspartate cycle.
    Archives of biochemistry and biophysics, 1988, Volume: 264, Issue:1

    Topics: Animals; Aspartic Acid; Binding Sites; Calcium; Glucagon; Glutamates; Glutamic Acid; Intracellular Membranes; Ketoglutaric Acids; Malates; Mitochondria, Liver; Onium Compounds; Organophosphorus Compounds; Oxidation-Reduction; Rats; Rats, Inbred Strains

1988
Gluconeogenesis in the amphibian retina. Lactate is preferred to glutamate as the gluconeogenic precursor.
    The Biochemical journal, 1988, Sep-01, Volume: 254, Issue:2

    Topics: Animals; Calcimycin; Glucagon; Gluconeogenesis; Glucose; Glutamates; Glutamic Acid; Glycogen; In Vitro Techniques; Lactates; Lactic Acid; Potassium; Rana catesbeiana; Retina; Vasoactive Intestinal Peptide

1988
Hormonal regulation of mitochondrial function. Description of a system capable of mimicking several effects of glucagon.
    Biochimica et biophysica acta, 1983, Aug-31, Volume: 724, Issue:2

    Topics: Adenosine Diphosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Electron Transport; Glucagon; Glutamates; Glutamic Acid; Kinetics; Male; Mitochondria, Liver; Oligomycins; Osmolar Concentration; Oxidative Phosphorylation; Rats; Rats, Inbred Strains

1983
Distinct effects of glucagon and vasopressin on proline metabolism in isolated hepatocytes. The role of oxoglutarate dehydrogenase.
    The Biochemical journal, 1984, Jan-15, Volume: 217, Issue:2

    Topics: Amino Acids; Animals; Calcium; Glucagon; Gluconeogenesis; Glutamates; Glutamic Acid; In Vitro Techniques; Ketoglutarate Dehydrogenase Complex; Ketoglutaric Acids; Ketone Oxidoreductases; Liver; Male; Proline; Rats; Rats, Inbred Strains; Urea; Vasopressins

1984
Effects of glucagon in vivo on the N-acetylglutamate, glutamate and glutamine contents of rat liver.
    The Biochemical journal, 1984, Feb-01, Volume: 217, Issue:3

    Topics: Animals; Glucagon; Glutamates; Glutamic Acid; Glutamine; Liver; Rats; Rats, Inbred Strains

1984
Possible role of Pi supply in mitochondrial actions of glucagon.
    European journal of biochemistry, 1984, Jun-15, Volume: 141, Issue:3

    Topics: Animals; Cell Compartmentation; Citrulline; Glucagon; Glutamates; Glutamic Acid; Hormones; In Vitro Techniques; Liver; Male; Mitochondria, Liver; Phosphates; Rats; Rats, Inbred Strains; Urea

1984
In vivo threonine oxidation rate is dependent on threonine dietary supply in growing pigs fed low to adequate levels.
    The Journal of nutrition, 1995, Volume: 125, Issue:10

    Topics: Animals; Blood Glucose; Butyrates; Carbon Radioisotopes; Diet; Dose-Response Relationship, Drug; Eating; Female; Food, Fortified; Glucagon; Glutamic Acid; Glycine; Humans; Infusions, Intravenous; Insulin; Liver; Models, Biological; Oxidation-Reduction; Pancreas; Swine; Threonine

1995
Hormonal control of hepatic glutaminase.
    Advances in enzyme regulation, 1995, Volume: 35

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Experimental; Dietary Proteins; Endotoxins; Enzyme Activation; Enzyme Inhibitors; Ethers, Cyclic; Glucagon; Glutamic Acid; Glutaminase; Glutamine; Mitochondria, Liver; Okadaic Acid; Phosphates; Rats; Signal Transduction; Thionucleotides

1995
Glutamate stimulates glucagon secretion via an excitatory amino acid receptor of the AMPA subtype in rat pancreas.
    European journal of pharmacology, 1993, Jun-11, Volume: 237, Issue:1

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Glucagon; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Islets of Langerhans; Kainic Acid; Male; Pancreas; Quinoxalines; Quisqualic Acid; Rats; Rats, Wistar; Receptors, Amino Acid; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate

1993
Glucose potentiation of arginine-induced insulin secretion is impaired in subjects with a glucokinase Glu256Lys mutation.
    Diabetes, 1994, Volume: 43, Issue:12

    Topics: Adult; Arginine; Blood Glucose; Drug Synergism; Female; Glucagon; Glucokinase; Glucose; Glucose Tolerance Test; Glutamic Acid; Humans; Insulin; Insulin Secretion; Lysine; Male; Middle Aged; Mutation

1994
Role of glutamate in regulating hypothalamic proglucagon-derived peptide secretion in vitro.
    Life sciences, 1995, Mar-10, Volume: 56, Issue:16

    Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cells, Cultured; Female; Glucagon; Glucagon-Like Peptide 1; Glutamic Acid; Hypothalamus; Peptide Fragments; Pregnancy; Protein Precursors; Quisqualic Acid; Rats

1995
Use of labeling pattern of liver glutamate to calculate rates of citric acid cycle and gluconeogenesis.
    The American journal of physiology, 1997, Volume: 272, Issue:1 Pt 1

    Topics: Animals; Citric Acid Cycle; Dichloroacetic Acid; Enzyme Inhibitors; Glucagon; Gluconeogenesis; Glutamic Acid; Lactic Acid; Liver; Methods; Osmolar Concentration; Picolinic Acids; Pyruvate Kinase; Pyruvic Acid; Rats

1997
Glucagon-like peptide-1 modulates neuronal activity in the rat's hippocampus.
    Neuroreport, 1999, Jun-03, Volume: 10, Issue:8

    Topics: Animals; Aspartic Acid; Cerebral Cortex; Electroencephalography; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Glutamic Acid; Glutamine; Hippocampus; Injections, Intraventricular; Male; Neurons; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Wistar; Receptors, Glucagon; Stimulation, Chemical; Ventromedial Hypothalamic Nucleus

1999
Localization and function of group III metabotropic glutamate receptors in rat pancreatic islets.
    American journal of physiology. Endocrinology and metabolism, 2002, Volume: 282, Issue:6

    Topics: Animals; Benzoates; Cell Membrane; Colforsin; Cyclic AMP; Cytoplasmic Granules; DNA Primers; Excitatory Amino Acid Antagonists; Female; Gene Expression; Glucagon; Glutamic Acid; Glycine; Islets of Langerhans; Microscopy, Immunoelectron; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; Synaptophysin; Tissue Distribution

2002
Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 302, Issue:3

    Topics: Animals; Basal Ganglia; Cell Death; Cell Survival; Cells, Cultured; Choline O-Acetyltransferase; Cyclic AMP; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Exenatide; Glial Fibrillary Acidic Protein; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glutamic Acid; Hippocampus; Ibotenic Acid; Immunohistochemistry; Nerve Degeneration; Neurons; Parasympathetic Nervous System; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Receptors, Glucagon; Venoms

2002
The prevalent Glu23Lys polymorphism in the potassium inward rectifier 6.2 (KIR6.2) gene is associated with impaired glucagon suppression in response to hyperglycemia.
    Diabetes, 2002, Volume: 51, Issue:9

    Topics: Adult; Alleles; Female; Gene Frequency; Glucagon; Glutamic Acid; Humans; Hyperglycemia; Insulin; Insulin Secretion; Islets of Langerhans; Lysine; Male; Polymorphism, Genetic; Potassium Channels, Inwardly Rectifying

2002
Secretory granule-mediated co-secretion of L-glutamate and glucagon triggers glutamatergic signal transmission in islets of Langerhans.
    The Journal of biological chemistry, 2003, Jan-17, Volume: 278, Issue:3

    Topics: Animals; Base Sequence; DNA Primers; Glucagon; Glutamic Acid; Islets of Langerhans; Male; Rats; Rats, Wistar; Signal Transduction

2003
Three distinct epitopes on the extracellular face of the glucagon receptor determine specificity for the glucagon amino terminus.
    The Journal of biological chemistry, 2003, Jul-25, Volume: 278, Issue:30

    Topics: Amino Acid Sequence; Aspartic Acid; Cell Line; DNA, Complementary; Dose-Response Relationship, Drug; Epitopes; Genes, Reporter; Glucagon; Glutamic Acid; Humans; Inhibitory Concentration 50; Models, Biological; Molecular Sequence Data; Point Mutation; Protein Binding; Protein Structure, Tertiary; Receptors, Glucagon; Sequence Homology, Amino Acid

2003
Learning from the gut.
    Nature medicine, 2003, Volume: 9, Issue:9

    Topics: Animals; Brain-Derived Neurotrophic Factor; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucose; Glutamic Acid; Insulin; Insulin Secretion; Learning; Memory; Mice; Nerve Degeneration; Neuronal Plasticity; Pancreas; Peptide Fragments; Protein Precursors; Rats; Receptors, Neurotransmitter; Signal Transduction

2003
Glucagon-like peptide 1 modulates calcium responses to glutamate and membrane depolarization in hippocampal neurons.
    Journal of neurochemistry, 2003, Volume: 87, Issue:5

    Topics: Animals; Calcium; Calcium Channels; Cell Death; Cell Membrane; Cells, Cultured; Glucagon; Glucagon-Like Peptide 1; Glutamic Acid; Hippocampus; Neurons; Neuroprotective Agents; Neurotoxins; Patch-Clamp Techniques; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley

2003
Lys9 for Glu9 substitution in glucagon-like peptide-1(7-36)amide confers dipeptidylpeptidase IV resistance with cellular and metabolic actions similar to those of established antagonists glucagon-like peptide-1(9-36)amide and exendin (9-39).
    Metabolism: clinical and experimental, 2004, Volume: 53, Issue:2

    Topics: Adenylyl Cyclases; Amino Acid Substitution; Animals; Blood Glucose; Cells, Cultured; Cricetinae; Cyclic AMP; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Fibroblasts; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Glutamic Acid; Humans; Hypoglycemic Agents; Insulin; Islets of Langerhans; Lung; Lysine; Mice; Mice, Obese; Peptide Fragments; Peptides; Receptors, Glucagon; Spectrometry, Mass, Electrospray Ionization

2004
Metabotropic glutamate receptor type 4 is involved in autoinhibitory cascade for glucagon secretion by alpha-cells of islet of Langerhans.
    Diabetes, 2004, Volume: 53, Issue:4

    Topics: Animals; Cyclopentanes; Excitatory Amino Acid Agonists; Gene Expression Profiling; Glucagon; Glucose; Glutamic Acid; Islets of Langerhans; Male; Pertussis Toxin; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Tricarboxylic Acids

2004
Compartmentation of glycolysis and glycogenolysis in the perfused rat heart.
    NMR in biomedicine, 2004, Volume: 17, Issue:2

    Topics: Animals; Energy Metabolism; Glucagon; Glucose; Glutamic Acid; Glycogen; Glycolysis; Heart; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Myocardium; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Signal Transduction

2004
A novel variant of ionotropic glutamate receptor regulates somatostatin secretion from delta-cells of islets of Langerhans.
    Diabetes, 2004, Volume: 53, Issue:7

    Topics: Animals; Culture Techniques; Excitatory Amino Acid Antagonists; Glucagon; Glutamic Acid; Hormones; Islets of Langerhans; Male; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Glutamate; Somatostatin

2004
Glucagon-like peptide 1 excites hypocretin/orexin neurons by direct and indirect mechanisms: implications for viscera-mediated arousal.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Sep-15, Volume: 24, Issue:37

    Topics: Action Potentials; Afferent Pathways; Animals; Arousal; Choline; Digestive System; Eating; Exenatide; Genes, Reporter; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glutamic Acid; Hypothalamic Hormones; Hypothalamus; Intracellular Signaling Peptides and Proteins; Melanins; Mice; Mice, Transgenic; Neurons; Neuropeptides; Orexin Receptors; Orexins; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Peptide Fragments; Peptides; Pituitary Hormones; Protein Precursors; Receptors, G-Protein-Coupled; Receptors, Glucagon; Receptors, Neuropeptide; Sodium Channel Blockers; Solitary Nucleus; Synaptic Transmission; Tetrodotoxin; Venoms; Viscera

2004
Phosphorylation and transactivation of Pax6 by homeodomain-interacting protein kinase 2.
    The Journal of biological chemistry, 2006, Mar-17, Volume: 281, Issue:11

    Topics: Alanine; Animals; Binding Sites; Carrier Proteins; Cell Line; Cell Line, Tumor; DNA Mutational Analysis; Eye Proteins; Glucagon; Glutamic Acid; Green Fluorescent Proteins; Homeodomain Proteins; Humans; Immunohistochemistry; Luciferases; Mass Spectrometry; Mice; Mutagenesis, Site-Directed; Mutation; p300-CBP Transcription Factors; Paired Box Transcription Factors; PAX6 Transcription Factor; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Threonine; Transcription, Genetic; Transcriptional Activation; Transfection

2006
Insulin regulates islet alpha-cell function by reducing KATP channel sensitivity to adenosine 5'-triphosphate inhibition.
    Endocrinology, 2006, Volume: 147, Issue:5

    Topics: Adenosine Triphosphate; Androstadienes; Animals; Body Weight; Cell Line; Diabetes Mellitus; Dose-Response Relationship, Drug; Glucagon; Glucagon-Secreting Cells; Glucose; Glutamic Acid; Green Fluorescent Proteins; Guinea Pigs; Humans; Inhibitory Concentration 50; Insulin; Islets of Langerhans; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Phosphatidylinositol 3-Kinases; Potassium; Rabbits; Signal Transduction; Wortmannin

2006
Cerebral glutamate metabolism during hypoglycaemia in healthy and type 1 diabetic humans.
    European journal of clinical investigation, 2006, Volume: 36, Issue:3

    Topics: Adult; Blood Glucose; Creatine; Diabetes Mellitus, Type 1; Energy Metabolism; Epinephrine; Glucagon; Glucose; Glucose Clamp Technique; Glutamic Acid; Human Growth Hormone; Humans; Hydrocortisone; Hypoglycemia; Insulin; Magnetic Resonance Spectroscopy; Male; Occipital Lobe

2006
Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia.
    Cell metabolism, 2007, Volume: 5, Issue:5

    Topics: Animals; Electrophysiology; Glucagon; Glucose-6-Phosphatase; Glutamic Acid; Hypoglycemia; Hypothalamus; In Situ Hybridization; Insulin; Liver; Mice; Mice, Transgenic; Neurons; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Synapses; Trans-Activators; Transcription Factors; Vesicular Glutamate Transport Protein 2

2007
Glutamate availability is important in intramuscular amino acid metabolism and TCA cycle intermediates but does not affect peak oxidative metabolism.
    Journal of applied physiology (Bethesda, Md. : 1985), 2008, Volume: 105, Issue:2

    Topics: Adult; Alanine Transaminase; Amino Acids; Anaerobic Threshold; Blood Glucose; Carbon Dioxide; Citric Acid Cycle; Glucagon; Glutamic Acid; Humans; Insulin; Leg; Male; Muscle, Skeletal; Nitrogen; Organ Size; Oxidation-Reduction; Oxygen; Oxygen Consumption; Physical Fitness

2008
Glutamate is a positive autocrine signal for glucagon release.
    Cell metabolism, 2008, Volume: 7, Issue:6

    Topics: Animals; Autocrine Communication; Blood Glucose; Cells, Cultured; Glucagon; Glucagon-Secreting Cells; Glutamic Acid; Haplorhini; Homeostasis; Humans; Mice; Receptors, AMPA; Receptors, Kainic Acid; Receptors, Metabotropic Glutamate

2008
A critical role for highly conserved Glu(610) residue of oligopeptidase B from Trypanosoma brucei in thermal stability.
    Journal of biochemistry, 2010, Volume: 147, Issue:2

    Topics: Adrenocorticotropic Hormone; Animals; Calorimetry, Differential Scanning; Circular Dichroism; Enzyme Activation; Enzyme Stability; Glucagon; Glutamic Acid; Hot Temperature; Mutagenesis, Site-Directed; Mutation; Protozoan Proteins; Salts; Serine Endopeptidases; Trypanosoma brucei brucei; Trypsin; Urea

2010
Characteristics and functions of {alpha}-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptors expressed in mouse pancreatic {alpha}-cells.
    Endocrinology, 2010, Volume: 151, Issue:4

    Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium Channels; Cell Size; Electrophysiology; Excitatory Amino Acid Agonists; Exocytosis; Glucagon; Glucagon-Secreting Cells; Glutamic Acid; Immunohistochemistry; Insulin; Insulin-Secreting Cells; Kainic Acid; Male; Membrane Potentials; Mice; Receptors, AMPA; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2010
Reduction of plasma membrane glutamate transport potentiates insulin but not glucagon secretion in pancreatic islet cells.
    Molecular and cellular endocrinology, 2011, May-16, Volume: 338, Issue:1-2

    Topics: Alanine; Animals; Aspartic Acid; Cell Membrane; Cells, Cultured; Dicarboxylic Acids; Epinephrine; gamma-Aminobutyric Acid; Glucagon; Glucagon-Secreting Cells; Glucose; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Glutamine; Insulin; Insulin Secretion; Insulin-Secreting Cells; Ketoglutaric Acids; Malates; Male; Pyrrolidines; Rats; Rats, Wistar; Transcription, Genetic

2011
Insulin and glucagon share the same mechanism of neuroprotection in diabetic rats: role of glutamate.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2011, Volume: 301, Issue:3

    Topics: Analysis of Variance; Animals; Blood Glucose; Brain; Diabetes Mellitus, Experimental; Glucagon; Glutamic Acid; Hypoglycemic Agents; Infarction, Middle Cerebral Artery; Insulin; Male; Neuroprotective Agents; Oxaloacetic Acid; Rats; Rats, Sprague-Dawley; Time Factors

2011
The effects of insulin, glucagon, glutamate, and glucose infusion on blood glutamate and plasma glucose levels in naive rats.
    Journal of neurosurgical anesthesiology, 2011, Volume: 23, Issue:4

    Topics: Animals; Blood Glucose; Glucagon; Glucose; Glutamic Acid; Hypoglycemic Agents; Injections, Intraperitoneal; Injections, Intravenous; Insulin; Male; Pancreas; Rats; Rats, Sprague-Dawley

2011
EphA5-EphrinA5 interactions within the ventromedial hypothalamus influence counterregulatory hormone release and local glutamine/glutamate balance during hypoglycemia.
    Diabetes, 2013, Volume: 62, Issue:4

    Topics: Animals; Blood Glucose; Ephrin-A5; Epinephrine; Gene Expression Regulation; Glucagon; Glucose; Glutamic Acid; Glutamine; Hypoglycemia; Insulin; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptor, EphA5; Ventromedial Hypothalamic Nucleus

2013
Dynein mutations associated with hereditary motor neuropathies impair mitochondrial morphology and function with age.
    Neurobiology of disease, 2013, Volume: 58

    Topics: Aging; Animals; Cells, Cultured; Cytoplasmic Dyneins; Embryo, Mammalian; Female; Glucagon; Glutamic Acid; Humans; Insulin; Lysine; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mitochondria; Muscular Atrophy, Spinal; Mutation; Superoxide Dismutase; Superoxide Dismutase-1; Transfection

2013
A new strategy for recovery of two peptides without Glu employing glutamate-specific endopeptidase from Bacillus licheniformis.
    Enzyme and microbial technology, 2014, Jan-10, Volume: 54

    Topics: Bacillus; beta-Defensins; Biotechnology; Chromatography, High Pressure Liquid; Endopeptidases; Glucagon; Glutamic Acid; Humans; Peptides; Recombinant Proteins; Substrate Specificity

2014
Coordinated changes in hepatic amino acid metabolism and endocrine signals support hepatic glucose production during fetal hypoglycemia.
    American journal of physiology. Endocrinology and metabolism, 2015, Feb-15, Volume: 308, Issue:4

    Topics: Algorithms; Amino Acids; Animals; Biological Transport; Blood Glucose; Carbon Radioisotopes; Disease Models, Animal; Endocrine System Diseases; Female; Fetal Blood; Glucagon; Gluconeogenesis; Glutamic Acid; Glycine; Hydrocortisone; Hypoglycemia; Insulin; Liver; Sheep, Domestic; Up-Regulation

2015
Effects of three major amino acids found in Japanese broth on glucose metabolism and gastric emptying.
    Nutrition (Burbank, Los Angeles County, Calif.), 2018, Volume: 46

    Topics: Adult; Amino Acids; Animals; Aspartic Acid; Blood Glucose; C-Peptide; Cross-Over Studies; Diet; Female; Fishes; Food, Preserved; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glutamic Acid; Histidine; Humans; Insulin; Japan; Kelp; Male; Oryza

2018
Neurotrophic and neuroprotective effects of a monomeric GLP-1/GIP/Gcg receptor triagonist in cellular and rodent models of mild traumatic brain injury.
    Experimental neurology, 2020, Volume: 324

    Topics: Animals; Brain Injuries, Traumatic; Cell Line; Cyclic AMP; Dose-Response Relationship, Drug; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide-1 Receptor; Glutamic Acid; Humans; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Neuroprotective Agents; Nootropic Agents; Oxidative Stress; Space Perception; Visual Perception

2020
Characteristic changes in plasma glutamate levels and free amino acid profiles in Japanese patients with type 1 diabetes mellitus.
    Journal of diabetes investigation, 2023, Volume: 14, Issue:1

    Topics: Amino Acids; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; East Asian People; Glucagon; Glutamic Acid; Humans; Insulin

2023